<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3M8</accession>
    <name>R7I3M8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat protein CotH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46509">
        <property type="protein sequence ID" value="CDE46509"/>
        <property type="gene ID" value="BN770_00917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="433" mass="50173" checksum="104783424CD514EF" modified="2013-07-24" version="1">METYYTTPIVCITVDPDELWNEENGMLAAGPNIDKSGGIPFKNTIYRKYGKTPREGYMEYYDVDGTQLISQGVAIGLIGNYSLDMPQKSMKLRAKSLYGSKTFAAALFDDRPYTEYKSLVLRNSGNDAMSTRLLDGFQSRLLDAYGTQVIHQAWKPVTVFLNGKYWGHMNLRERVDRFFIAQFEGLPLDQADEMDILEANGSVNFGSNKAYRAMLKKIKAGSPATNPDDLQYILDNVDVDNLFEYMALEMFVGNSDIGNIRYYRLHQEGSKWKWIWYDADYGLYSSKFNSPWSYLKVKGMGEQKIDNTIFLKLLEHPDYKRKFLEKLADVYKTFTTEYMTQVLDGVLAEIQPEMKNHWERWGELNDKAVTSEVPTTIDGAYTYWESRVNRLYNTLKVRPHRLWDFIKDEFKLTKTEMEELFGPQPDYPDDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3W4</accession>
    <name>R7I3W4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46589">
        <property type="protein sequence ID" value="CDE46589"/>
        <property type="gene ID" value="BN770_00956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="297"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="4">
        <location>
            <begin position="520"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="579" mass="64764" checksum="FB79547CF6087C4A" modified="2013-07-24" version="1">MQAHGIDLYIIPTDDFHASEYVGAHFRGRHYVSGFTGSAGTLVVTADWAGLWTDGRYFLQAGQQLEGSGIELCKMGEPGVPTIPEYLEKTLEAGQTLGFDGRVVTARQYEGYQRIAEKKQGKIVSDVDLLDEIWAERPALSAEPAWELPVSLTGRSRQEKLHQVRREMESLGADALVLSSLMDVCWLMNLRGNDVDCTPVMLSFAAVTMTDAVLFVNPAILSTEIQAHLKEDGVTIRPYACVYEYTKKLPEDSTVMMNLNVVNSLIRACVPASVRVIDHVDPTELPKAVKNATEVEGFRKAHVQDGVAVTRLMYWLKHNVGKIPMDELSVAEKLEEFRRERPDYIGPSFAPIIAYGAHGAIVHYSPTRESNIPVEPRSLLLADTGGHYLQGTTDITRTFAMGETTDEEKKFFTLVLKGHLHLGNAHWKYGCTGANLDYLAREPLWQENMDYNHGTGHGVGYVLSVHEGPQRIHWRGAPIPLEPGMVTSDEPGFYLEGKFGIRHENLTVVCEGETNAYGRFLHFDYLTMVPFDLDAVDTRYLNEDDKKLLNAYHAKVRETILPYLAGDEAEWLLHATREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I466</accession>
    <name>R7I466_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46679">
        <property type="protein sequence ID" value="CDE46679"/>
        <property type="gene ID" value="BN770_00991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="355" mass="39987" checksum="C805AFE22232C19C" modified="2013-07-24" version="1">MTLNDTIRALRRERGMTQEQLAEAMNVSAAAVSKWENGQSVPDILVLTALADFFEVSLDALVGYTVQAHRRGDMVARIRQLVVQKKHTEATCAAREALRRYPNSFDVVYEATQAYGYSGMEQNRPEDLRKALSLAERAMVLINQDQEREKHIRPESIWSLMGNYHAHLNEYDEAIRCYENGNVAEVNDIAIANSQTELGCYDHALPKLSRGLVVSVIRLFNAATGAMNCLIASGRQQDAIALASWLCRALDGMESTSGSYIWKMKTILYTNSARAMVRMGRMNDAELQLRQAIHCARRFDAAPSYSVNGFRFYWGEEKSILDITGETAMSAIERCIDRNDDARAELREIFARLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4F0</accession>
    <name>R7I4F0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46525">
        <property type="protein sequence ID" value="CDE46525"/>
        <property type="gene ID" value="BN770_00919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="182" mass="20552" checksum="4C719AEC5B5B001D" modified="2013-07-24" version="1">MVGAVPDFQPVGVIAVFIRHRGSIRRHNLAENQSLIITQRAACGMHQIILRPCGIIRLLHGLFGADDDHNCHQRNQHSADEDIQHTAFLLTIFHSGRHLLRLCATLPFFGLIRLHGNPFCGQEDIHPRRGAGRSGGFPPSVFLSTNRTMQHRPILHCITKTYSRASIMTILRGFFIFWSQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4F5</accession>
    <name>R7I4F5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46530">
        <property type="protein sequence ID" value="CDE46530"/>
        <property type="gene ID" value="BN770_00924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435378" evidence="1">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="198" mass="21775" checksum="04586B9688ABB566" modified="2013-07-24" version="1">MKKFFSLFLAVLLIFSCWTAATAESTDAVSGAPLDNDIEIVYKEHFDDMVTRYADELTEAELLVSADVYDAIGMIRFDSEDSLAARQRIYGIASADDLHAILTGYFDPNDAAYTADAALDARLQAILAACGLNPEDYDISVIRNLSGMPEPITGTNWYCTLIRKGIEVAEDETNPYDMVIVLYGDEMTVGAFVLNPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4L9</accession>
    <name>R7I4L9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46590">
        <property type="protein sequence ID" value="CDE46590"/>
        <property type="gene ID" value="BN770_00957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33299" checksum="336FE67AD3EFC2B4" modified="2013-07-24" version="1">MTPDTLEGSIHDLTQNILADYTAGRPIDRIEPFNQPDRDVIIALIGKLRRIVFPGYFRDPAYHVYSAAHSLSALIEDTAYLLQKQIAIALRCGSSVTQEAAADIDRQAQEMTVRFLEKIPDVRALLATDLQAFYDGDPAATSLDEIIIAYPGLLAITVNRLAHELFLLKVPLIPRIMTEYAHGRTGIDIHPGATIGKYFFIDHGTGIVVGETTVIGDSVKLYQGVTLGALSTRGGQSLRGHRRHPTIGDRVTIYSGASVLGGDTVIGHDAVIGGNAFITHSIAPGMRVSVKNQELEMRMMKDVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4S2</accession>
    <name>R7I4S2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ORF">BN770_00900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46491">
        <property type="protein sequence ID" value="CDE46491"/>
        <property type="gene ID" value="BN770_00900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE46491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="164" mass="17924" checksum="552A92AEF69482B3" modified="2013-07-24" version="1">MIVLGIDPGYALMGWGVVEAQGARMRLLGYGCVETQAGVPMQHRLRALQLGVRDLVNIYHPDDVAFEELFFARNVTTALMVGAARGAAIISAAEYTESLYEYTPMQIKQAVTGYGKADKKQIQQMVKLLLGMKEIPKPDDAADAIACAITHCQCGAAKEQFRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4U4</accession>
    <name>R7I4U4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1858 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46665">
        <property type="protein sequence ID" value="CDE46665"/>
        <property type="gene ID" value="BN770_00979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39341">
        <property type="entry name" value="PTHR39341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="70" mass="7632" checksum="3EBA6AED05D24DD2" modified="2013-07-24" version="1">MINKDMTVGEVLRSCSDAAMDAVVKIFTDMGMHCLFCPHSTAETLEEAAMVHGNDVDELVAKLNTVFQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I502</accession>
    <name>R7I502_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphodiesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46571">
        <property type="protein sequence ID" value="CDE46571"/>
        <property type="gene ID" value="BN770_00938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="160" mass="18555" checksum="7F37679EC138D1F3" modified="2013-07-24" version="1">MRALVLSDIHGEESQLRWMLEETWKMTGKIDGYFFLGDGVDDFAQAENFIRRRDPDALMLDVRGNNDFCCPNAPYYRVTDFGGVRLYLTHGHLERVKLTRSFLYERAREEKCDIAFYGHTHEPDMVTGVPMLVNPGAVCREQMAMLEVEDGRPRVKMLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I537</accession>
    <name>R7I537_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hut operon positive regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HutP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46358">
        <property type="protein sequence ID" value="CDE46358"/>
        <property type="gene ID" value="BN770_00839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006547">
        <property type="term" value="P:histidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015111">
        <property type="entry name" value="Regulatory_HutP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036482">
        <property type="entry name" value="Regulatory_HutP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09021">
        <property type="entry name" value="HutP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111064">
        <property type="entry name" value="SSF111064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="139" mass="14511" checksum="ED55F9F6EAA9986E" modified="2013-07-24" version="1">MLEIIGDSRAVARAAIQLAMTATREEETELKASLTEKDIVGAASDFGGTFVDSMMKMIERAVVAAKREGVISDTHREEGAVAGAAHDAVCQVSEKAMGFSVGGKIGVARSGEHVAVAVFFTVGLVHLNEVVVGMGHRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5E4</accession>
    <name>R7I5E4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YabP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46711">
        <property type="protein sequence ID" value="CDE46711"/>
        <property type="gene ID" value="BN770_01010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022476">
        <property type="entry name" value="Spore_YabP/YqfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038705">
        <property type="entry name" value="YabP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07873">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10188" checksum="02756DB08F52F66C" modified="2013-07-24" version="1">MKEPTVPQKPCGLVIENRKKAVLTGVKEVDRFDETAVVLETWGGRLTLTGSGLHVSALQLEEGRLLVDGDIDGVQYEQGRARRKGGFLRRAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5F4</accession>
    <name>R7I5F4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46865">
        <property type="protein sequence ID" value="CDE46865"/>
        <property type="gene ID" value="BN770_01064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435429" evidence="1">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19434" checksum="5003FFE8AE0D8349" modified="2013-07-24" version="1">MKKILTVVLALLLLCSSCLAEGLDYASMTDTQLHDIVDAARNELTKRELVAEGKTLLFEQNGVSVYLTSDFKADSIHTDSMHFMRASVIVVNDSDINVRVGVESMSVNGWEVSNSGFSSVSPGKKLKDELTFNAVDTDITTVEEIETIEITFRLSNADTYMFFADVPAITLHFNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5G0</accession>
    <name>R7I5G0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46498">
        <property type="protein sequence ID" value="CDE46498"/>
        <property type="gene ID" value="BN770_00907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="169" mass="18430" checksum="389C275F71D5C007" modified="2013-07-24" version="1">MLPESLVAARKLLEEITPLQTDCGLVCGGACCQTHPGEETGMLLFPGEAEMYRGEEGFTLVDSPHGTILVCEGRCNRANRPLACRMFPLVMLLRPDGVKIATDAAAQAVCPLARQGKSALSQDFVAAVRQAANLLAQDNQQASHLRRLTDMQDELKALRAQYRGRKEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5L2</accession>
    <name>R7I5L2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type antimicrobial peptide transport system permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46756">
        <property type="protein sequence ID" value="CDE46756"/>
        <property type="gene ID" value="BN770_00069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435433" evidence="7">
        <location>
            <begin position="28"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="106"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2_2" evidence="9">
        <location>
            <begin position="452"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE46756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="554" mass="61568" checksum="1B6D4457F92C0BBB" modified="2013-07-24" version="1">MKKLGKWWQWALLAAFAAALVFGAVQAKQVGDHLQYLVPAPAQQTEDNSGEDGDTKAAPNQPIADQVKTLENAAGEWDTTTMLRWTIGGVIEKTSISGGDISSDTRVELVGKYGFQVRQKLLRYGRLPYEEELKSGRKVAVLDEDLALKLFRVADPLGRKVYINGESYEVIGIARHSKRVGEYQAYTAYIPLNSVIETSTTVDALLVEAIPKPGTGASVSFKSVVTGWQSGGSMFDLGKEGMSATLWLRVLLFLIGMTVLLRFIAFLNGRVKHYGKRYRQRLQEKYAISLMPELTGAVLLFILGYGVSAIFAALLMNYIIQPVYTFPEWIPTVLVEWKDIAKAFWNVWQDTAVMQELRTPEILRLRWLALLVQGCSAGAGALLGILYGRMRSSRQLVADSVNALYHQGATVSVIHTRKVIDMTDLGYVITLDGEIIPRRAKTVPMVRIINAEAILRQMPAGKRDGAFVLEVVDEQIPANNARWLITCQDGEKTIVEANRDWDIQLPIAVLTRIVYGTQTFADFLECNAGYDMRMRSPAMDGMFGHHLTIDGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5P1</accession>
    <name>R7I5P1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46791">
        <property type="protein sequence ID" value="CDE46791"/>
        <property type="gene ID" value="BN770_01020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="269" mass="30598" checksum="E8AD525B4C594D62" modified="2013-07-24" version="1">MKTWIASWKPYFSLYRLKAMQETQYRAAALGGLVTQAFFGLLYVFLYTALFRGENQAELAETITYVWLQQMFFRVLLMNDTELIQQVMTGGLAYAVLRPVDQYRFAFVRNMAQRHVNALMRLVPMIALQFLLPTAWRMQPPESLLALMQAFVSLLIGVMNLCAIAGISGAILMQTMDNRGINAIITFISNAFAGNIIPLTLFPDSVQAIIRYQPFAQSLDAPIRMYLHAQAAGEWALNIGVQLLWLMLLVALGRRMWRYQLNRLTIQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I612</accession>
    <name>R7I612_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46931">
        <property type="protein sequence ID" value="CDE46931"/>
        <property type="gene ID" value="BN770_01079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="241" mass="26788" checksum="D295F074DE76D908" modified="2013-07-24" version="1">MPDLLPAAEALAEKRCLVTLHNQPDFVLLQPIDARDTLSQEMPLLAAQTTRSFLHVAFPVEAWNVDLSPWDAPPVFGREGFGHGAADTLDWLRSRLMPEVRAKYAISPDAPVILGGYSLAGLFSLWSAAQVDDFAAVAAMSPSVWFPGWADYADQHALRSRVVYLSLGDREEKSRNPVLASVGDAIRREDARLSERGVRHTLQWNVGNHFQDAEKRCADGFAWCMAQRKAEGKKTHEHETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6M1</accession>
    <name>R7I6M1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="5" type="ORF">BN770_01187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47260">
        <property type="protein sequence ID" value="CDE47260"/>
        <property type="gene ID" value="BN770_01187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8735" checksum="539EAA5607EF81F3" modified="2013-07-24" version="1">MAAKKKLTFEERLQQVEALIAKMESGEMPLEEAMQQYEAGLNALNALEKELTAAQQRLTVLRQQSGEDIEVPMEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6P2</accession>
    <name>R7I6P2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-phosphate adenylyltransferase GlgD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46202">
        <property type="protein sequence ID" value="CDE46202"/>
        <property type="gene ID" value="BN770_00778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011832">
        <property type="entry name" value="GlgDAde_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF6">
        <property type="entry name" value="PTHR43523:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02092">
        <property type="entry name" value="glgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="373" mass="41532" checksum="68A60A4ABD0214F2" modified="2013-07-24" version="1">MKNVMGVIYTGENDANLRELTLTRAIAALPVGGRYRVIDFLLSSMVNGGIKNVGVIMQKNYHSLMDHIGSGKEWDLHGKNDGLKVLPPFLTRENVGVYSGMLDALRSNTNYLSRSKQEYLVLSNSTIIYNANIAEFVAYHQNSGADITIMYTADPNMQRDELGCYLAVDESGMVTDMEVDPTHPNLPLTSMEVVVMKRELLRTLVDKGVAHGYHDFNRDVLLRLVTEGTARVNAWAYTGLCWRMDSVQSYFKFNMDMLDTQIRHRLFTAELPVYTKVRDEMPARYGDNVTVVNSLVADGCIIEGTVENSVLARGVRIAPGAHVKNCIIMQDGQVHNDASIENCILDKQTVIKRSARLIGPAAYPIVIAKNVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6P5</accession>
    <name>R7I6P5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000053">
        <property type="protein sequence ID" value="CDE47539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47539">
        <property type="protein sequence ID" value="CDE47539"/>
        <property type="gene ID" value="BN770_01279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436209" evidence="1">
        <location>
            <begin position="25"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="193" mass="20615" checksum="2F4F2793A84FC0D2" modified="2013-07-24" version="1">MRRMTRLLCLMLLFSLITFSCPLAEETTAPTGTPAPTPMLTAVPESALAPFNVVLPEDAHVEMAEGRITLVRGDSRVVAMVISRVPDEDPAAALPVLMQDFDPKTSETMDFDAQPGFCILGGVVNDAFGDGEDKITLMVLADSGELLILSGYNLARDHHALYLFLTELLENVSMDGAAVYVAEDAAATASPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6S3</accession>
    <name>R7I6S3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46963">
        <property type="protein sequence ID" value="CDE46963"/>
        <property type="gene ID" value="BN770_01089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="418" mass="47497" checksum="CACED6210BAFB427" modified="2013-07-24" version="1">MTAADYLMLISMVCIWALMAINVFLSVGGFLYYHQCSKTNGHVPIDEYPFVSIMVPAHNESVVIRRTVRALLNFDYPHDRYEIIVINDNSTDDTANVLKQIQAANPGRNLIVVNTDNVVGGKGKSNALNIGYSVAKGSVFAIYDADNTPEPQALRILVENLMSDSSLGAVIGKFRTRNRNASLLTRFVNIETLAHQCMNQAGRWFYFGLCTIPGTNFVMHRHIIEEIGGWDPDALSEDTEISFRIYRMGYKIKLVPQAVTWEQEPFRLGIWFKQRTRWAMGNLYVLINNFKYIFDPSGGKMRMDVLYYALVYILMAFTLVCSDTMFVLGVLGYSHVSLGGLSTMVWVMACALFECNVMLTLAQEKNEFNLQSAALVLLMLFTYSKLWVVVVLRAMWMTVKKIVSKTHYTWYKTERSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6V7</accession>
    <name>R7I6V7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000044">
        <property type="protein sequence ID" value="CDE47375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47375">
        <property type="protein sequence ID" value="CDE47375"/>
        <property type="gene ID" value="BN770_01227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010368">
        <property type="entry name" value="Com_YlbF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06133">
        <property type="entry name" value="Com_YlbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="SSF158622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="137" mass="15225" checksum="269458890C9CA22F" modified="2013-07-24" version="1">MKEVMMCAQKLAEAILNSDVYQHMHALEEQVTQDEDATKAIAAYMEKRTAVEQAMRKPDIDPTQLAEAAQELEDVQQAMNDCPIIRDMRDAQKKYQDMMDNVNRILRLVVTGETEDDKGGQPTSGCTGNCASCGGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6W7</accession>
    <name>R7I6W7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alani ne ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47018">
        <property type="protein sequence ID" value="CDE47018"/>
        <property type="gene ID" value="BN770_01112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="4">
        <location>
            <begin position="192"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="3">
        <location>
            <begin position="401"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="534" mass="59303" checksum="54549434795DAFBC" modified="2013-07-24" version="1">MINFLKWLPALATALAMLLAQRSLMHDFQLESYQFPGYFRTLRRNWKRALLPGITLAAYLTLLYLAYRSVDRMLDMSVGKILLALVNAALAVAGGWWCRSIFQQKKAKKPFVVTMRVKRTYIVMGVVYTLLCTPIALLTKVYFCGLLPLLLPLWVALGGLLAWPIEKLVSEMYFRDAQKKLAARPDIIKIGITGSYGKTSVKFILGTILQEKYQTLITPSSFNTPMGVTKIIRERLTPATQVFVAEMGARHVGDIKELCRLVHPRYGVLTSVGPQHLDTFHTLERIKNTKYELMDAVPADGCCFFPDDGAICRELYDRTEKEKRLCCLHYSPDADVWATDVTVSPMGSRFVLHTSAEEIACETRLLGEHNIQNILLAATVALHLGLTMRQVARGISKLQPVEHRLQLIPSPGITIIDDAFNSNPKGAEAAVKVLGAFQARRIIITPGMVELGGQEAAFNREFGRKICGNADIAILVGKKHTQPIAEGLLAAGFPQGNLHVVASLDEATALLRQIGRPGDIAMFENDLPDHYSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I714</accession>
    <name>R7I714_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acid sugar phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. NagD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47073">
        <property type="protein sequence ID" value="CDE47073"/>
        <property type="gene ID" value="BN770_01129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="267" mass="29058" checksum="202364FB5A611A49" modified="2013-07-24" version="1">MTDETIRAKLSGIRCFLLDMDGTFYLGDRIIPGGLEFLDALEKTGRTARFLTNNSSRSASTYAEKLARMGVPAAYRDVITSGQAAARYCLTHFPGKTGYLLGNPVLRAELTAMGLRFCDSDDADYVLAAFDTTLDYGKLCRVCDLIRTGKPYIATHPDFNCPTEHGFIPDLGAFMALIHASTGRWADVVIGKPNRGIVDEALARTGFALHEMAMVGDRLYTDVATGVNHGMTGILVLSGEAKRSDVDTSDVKPDLIFGRLSDIIPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7I6</accession>
    <name>R7I7I6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47809">
        <property type="protein sequence ID" value="CDE47809"/>
        <property type="gene ID" value="BN770_01370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014960">
        <property type="entry name" value="DUF1828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014961">
        <property type="entry name" value="DUF1829"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08861">
        <property type="entry name" value="DUF1828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08862">
        <property type="entry name" value="DUF1829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1828" evidence="1">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1829" evidence="2">
        <location>
            <begin position="160"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="255" mass="28766" checksum="2EC6C5AB751B4680" modified="2013-07-24" version="1">MSSSVSFDFIENYLSWIRSKSSQKTIGDFEEITTPFVDSHNDKIQFYVSRSPNGFSLTDDGYTLSDLEMCGCDVKSKKRKAFIQQIAESLGVSIKNGEITAEATEADIACKQHMMIQAMLKISDMFLTSSSRVKSLFFEEVDSFFSQYDIRNTPSIMMMGQSGLSHRFDFVIPASKKMPERIVTTLNAPSKQNVQAAIFAWNDVMKTRSTHSRGYIILNDAKKAVNPEIVAAIKSYELVAVHWKEREAYIPELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Q3</accession>
    <name>R7I7Q3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="5" type="ORF">BN770_01417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000070">
        <property type="protein sequence ID" value="CDE47889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47889">
        <property type="protein sequence ID" value="CDE47889"/>
        <property type="gene ID" value="BN770_01417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="63" mass="7111" checksum="EBBFA816C0433E60" modified="2013-07-24" version="1">MALPKGKISKARKHSRRANWKLTVPGIVECPQCHQMKLAHRVCKHCGFYKGVQVVAVNEEKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7T5</accession>
    <name>R7I7T5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47561">
        <property type="protein sequence ID" value="CDE47561"/>
        <property type="gene ID" value="BN770_01283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="192" mass="20431" checksum="BE8299207EA8ECF5" modified="2013-07-24" version="1">MNTTLLAALALGGAALSVKKPTQNHNLMRLPSFRGVAEVRASLPGRMRLYLPAVSANREAAKEMKRQLEATGVVHEVTLNFRLSTALIRYDETKVEAAVVQGAVLKLMGLTDALQKEPVSRIQSGLNTLMAAINHGLLEATNGLLDVRTLAGCALTFAGVKSLAVSGAAVPGAMTLLWWAASIWRRNDSGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7U3</accession>
    <name>R7I7U3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46587">
        <property type="protein sequence ID" value="CDE46587"/>
        <property type="gene ID" value="BN770_00954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="466" mass="53404" checksum="E8BC213A5AD4F7E5" modified="2013-07-24" version="1">MQKLHLGAAQCALDLGDGSERAEYVNQDYILHKLGRPHRAIGIMYTYYPHDKQWPQRISKACKDMNITFQWDYPYDDYFPFNADGQPWKQMRDIRRHGQDVALTLTLDCSLSDDELREVARMLRPYGRMTIRINHECGGTWFTHNKRFTYEQVGKFFAHFSDIIHQEAPNVRTVFCAGFAQADGKLEKEDEFAVAYRAADVWSADCYLALHYGWPYDVAEVGGGQYKADSVGMYYDMFRRTYERASSQFGCKPLVTAEFNTDGDVTGARHQGESVIRFAKAFRDHQANWFKAISLYQFRDRGRLGLEIEDPNNPAVGIEQPMLAQYRELLKDPYFQPSMTEMGEATFPAELRWGGAEDADGLAIPLHFEGNPEFCEMTVEQEIGLMVELHGKWFYKAPHVKTIDLMSAFFDAPLDTPADLKLNLFAPPADGVNVEDGHADWMTNYYATLQEAPKMRIRYEVPGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Y4</accession>
    <name>R7I7Y4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein ftsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47974">
        <property type="protein sequence ID" value="CDE47974"/>
        <property type="gene ID" value="BN770_01464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="394" mass="43422" checksum="9130C59C4546DAA9" modified="2013-07-24" version="1">MKITVPTIDFGTSKIVTMVAQSNGERCDIVGSGAVPYSGYLQDGWNNPDEIRDVIRTAIDQAQKTGNCRIHELNVGVPGMFTRVIVKEVHVSLTGPDPHVTAQDVRACFKLAEESGGDRIIHSAPAWFRVDDGKKTLSPVGIKGRELSAMIALVTADKYFIDDITYRLRDMDIEPREFYSTVAGEATYALSQDERDKTAMLIDIGYLCTDVMVMEGDALIFHKCLDIGGGHISADIAEQLNIPFPFVEEKIKQTYSFNSTNQDETYVIPATEDEPARTVRRDEVTPIIEAKVEEIAEAINKALEEGGVKLGKWSNVYLTGGGLILNKGGKDFLAGKLHRIIREAQRTNNKMTSHVFSSAVGLTILVVTTQEEQKAPEGGAKGLFSRAFRWLMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I895</accession>
    <name>R7I895_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48099">
        <property type="protein sequence ID" value="CDE48099"/>
        <property type="gene ID" value="BN770_00110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="249" mass="27622" checksum="ABF31CF40AA288FD" modified="2013-07-24" version="1">MNLSAEHVSVLRGRIEIVHDVSFSVSDGQWLMICGPNGAGKSTLLSAVSQELPYTGLVTLDGTDLRRMKPRPLARRMAMLRQLSDLAYAYTVEEVVSMGRYAHRGLLQADNSGAEAVERALQAVQLQNKRRQNILTLSGGERQRMLLAQVLCQEPDVLLLDEPGNHLDLRFQQELFLLIDAWRREPGHAVVSVVHDLSLARKFGTHALLLSSGRGTYGEISAILTPSALESAWQMDVVGWLRSLGDVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8B6</accession>
    <name>R7I8B6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000053">
        <property type="protein sequence ID" value="CDE47538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47538">
        <property type="protein sequence ID" value="CDE47538"/>
        <property type="gene ID" value="BN770_01278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="747" mass="84714" checksum="D6615656906590E7" modified="2013-07-24" version="1">MRFTQGYWVIRQDYVMSYATQTVRVIKNDKELHIISACRPIRHRGDILDGGSLDIVFTAPRKNIIRVQVTHFAGTPRKDPQFTTYEEDVTPEIREDDDYAYFTSGDLTARVSKGGNWSVDYMVGDRILTTSGWRGMGRALKKDGTPCSLLPHGTSYMSESLQLDVGECVYGLGERFGAYVKNGQTVDMWNADGGTASELAYKNIPFYMTNRGYGVLVENASDVSFEVATEKVERVQFSHEGETMVYDVIYGGTPKDTLDLYTALTGRPALVPAWSFGLWLSTSFTTNYDEQTTSSFINGMAERDIPLSVFHFDCYWMKGFNWCDFEWDHDTFPDPVGMLKRYHKKGLHICCWINPYIGQASPLFKEGMEHGYLLKKTDGSLFQTDMWQAGMAIVDFTNPDACKWYASYLYKLMDMGVDCFKTDFGERIPVRDIRWFDGSDPVYMHNYYTYLYNKVVFDVVKDRKGEGEAILFARSATVGGQQFPVHWGGDNSATYISMAETLRAGLSMSHSGFGYWSHDISGFESTAPADVYKRWVQFGLLSSHSRLHGSTSYRVPWLFDEESVDVCRKFTKLKCRLMPYLYGKAVEAHEHGVPMMRPMMLEFPDDPACDMLDRQYMLGDSLLVAPIFRKDGEVQYYLPDGTWTSLLDGGKVEGGHWQTEIHDFMSLPLMVRPGTVLPLGAHDDRPDYDYLDGVELHVYQLADGESETVEIPDTKGSVAATFTVTMKDGQAQVETDSTKPYTVVVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8D4</accession>
    <name>R7I8D4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48144">
        <property type="protein sequence ID" value="CDE48144"/>
        <property type="gene ID" value="BN770_01557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="51"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="285" mass="31657" checksum="899EFED9FDAF1453" modified="2013-07-24" version="1">MKKWKKVLLHVLIVLLVMAGVCGYFLFLYPHEQDFVESYYKVQSDQLTSHLRIVQLSDLHLREFGENNCDLVARIRALKPDIIAITGDMNDKKSDDMHVVTDLCAQLVEIAPVYYVPGNHEWPKIVFEGSTLASDLEALGVHFLADKYETVTIGSNTLLIGGIAEAPVSYEKYASGFLEDFAAQPGYKMLLVHYPEYYAEDTGALIGKDIDMALCGHAHGGQVRLPFLGALYTPDQGFLPDLTEGVQTISGTKVIISRGLGDEVGQILPRINNPPELVIIDANWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8G6</accession>
    <name>R7I8G6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000061">
        <property type="protein sequence ID" value="CDE47771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47771">
        <property type="protein sequence ID" value="CDE47771"/>
        <property type="gene ID" value="BN770_01351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="70" mass="8349" checksum="3067FB3654F80901" modified="2013-07-24" version="1">MPESTFILRFTHYDSSEIEEQEHTTAAAAWEAFRCFAEPDSFEIYSRIELVEHNWEEKQEYPLAQMTFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8G7</accession>
    <name>R7I8G7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46797">
        <property type="protein sequence ID" value="CDE46797"/>
        <property type="gene ID" value="BN770_01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="226"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="287" mass="31697" checksum="BA737F54D0E3FE2C" modified="2013-07-24" version="1">MQKAKVRENVKEYALLTLGTVIMTLGIYFFKFPNHFSTGGVSGMAVILSHYIPNFTNGDFVMMINVLLLIVGYIVLGKGFGGRTTYVSLLMSGLTWGLERIIPMNAPMTSQPLMELIFAVSLPAVGSAILFNLDASSGGTDIVAMILRKYTSLNIGRALMCSDLIITLMACVAFGMETGLFCILGLVIKSLLVDMVLENINTHKYFHIITTKPREIEQYITNVLKRGATELHGEGAYTHEGRTVLMTVMKRHEAIMLRKYVKMVDPHAFVLIMNTGEIIGKGFRGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Z4</accession>
    <name>R7I8Z4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000097">
        <property type="protein sequence ID" value="CDE48339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48339">
        <property type="protein sequence ID" value="CDE48339"/>
        <property type="gene ID" value="BN770_01661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12834" checksum="04F76FF8C9CB3972" modified="2013-07-24" version="1">MLTDYFEPFTLLKSTSCPDPCGGQLQQDVTEHPFRAALADALGEEGERGGKPFIHVTPYLLCPPETPLELDDIIRREKDGTHYRVCSRPEDRRTPLCAGFPYAEVRLERVEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I953</accession>
    <name>R7I953_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48135">
        <property type="protein sequence ID" value="CDE48135"/>
        <property type="gene ID" value="BN770_01550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="192"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="375" mass="43671" checksum="315356CE025FD06C" modified="2013-07-24" version="1">MDGKKRKVMFLIYSLCGGGAERVLVETVNRLPKDRYDVTLMTLFHDDTRAGMLSPEVHYRPALRVKNSRAQKILSGIMQYIIPPKWLYRWFFRSDADVEVAFMEAFPTKILAYSTNQHAKKYAWVHIDVQTYTKQDRLFRSMRHQKACYERFDGIYCVSENVQEAFSAKFGLTERVHVAYNMLDEQAIRRRKDEPVDDIPKGEFLMVSVGSLIPRKGFERLIHVCGLLKSRGYHFHLLILGKGELYEDLAEQVIDEHLQDSVQLLGFRDNPYPYMAAADLYVCPSYVEGFSTVVSEAVVLETPVVTTDCSGMREILGDSEYGLITQNTEESLFEGLRTMLDKPEVYQYYQQRVRERAPFFYMEERLKAYEEILDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9S5</accession>
    <name>R7I9S5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48053">
        <property type="protein sequence ID" value="CDE48053"/>
        <property type="gene ID" value="BN770_01512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="193" mass="21929" checksum="BBE03909A4B93762" modified="2013-07-24" version="1">MKQKSAPRPASLDARKIRRAYAPYRWEGRNFRLMVLILCIVLLLLWLWCETTEPASRNIAYLLMLMAMLASIAIGKSCVAIFSRYEERKQRFVEQSVRIQQVILPNSVRGAFMSCEGAPELAHVMSCCVIAVTLDGQKLRLLSACGDKRREALMRVMARSEQSPVTVIYGRYSRVIVGFRGAGYDGVDFERMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9S9</accession>
    <name>R7I9S9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genome sequencing data contig C274</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000099">
        <property type="protein sequence ID" value="CDE48350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48350">
        <property type="protein sequence ID" value="CDE48350"/>
        <property type="gene ID" value="BN770_01668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="251" mass="28592" checksum="318E653B88DC1499" modified="2013-07-24" version="1">MNVDSVSPEELEAAISYCTEALDDPKRVMDAAATLPYMLHAMGLVGVYPERIKALAKLLEEKTKDVDGLPYSFYSGIENVFHDLGEYDKALSYAQRALELSEKDTGTYYTTLHNYLQLKKEMGHLLEVQDVIIEALAKVKELFGEKSVICSSYKMAYISVLMERRENEKAYEEIQKLIPIVRECEGEVCAKEIEMMQIRVLAQMGREEEALELGEKMRPFIRQVGGDEWGLMKALDRTINNVKTGVYRPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9U3</accession>
    <name>R7I9U3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobB</name>
        <name evidence="6" type="ORF">BN770_01777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class U subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48664">
        <property type="protein sequence ID" value="CDE48664"/>
        <property type="gene ID" value="BN770_01777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01968">
        <property type="entry name" value="Sirtuin_ClassU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028628">
        <property type="entry name" value="Sirtuin_class_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27600" checksum="AE4C88FCFE3894FA" modified="2013-07-24" version="1">MYEELQQWIDESRRIVFFGGAGVSTESGIPDFRSQDGLYHQQFAYPPEEILSHTFFARHPEEFYRFYRAKMLPLDAQPNDAHRFLAQLEAGGRLTAVITQNIDGLHQKAGSKTVLELHGSIHRNYCLKCARFFPPEYIRDSEGVPKCPCGGIIKPDVVLYEEGLDDATVRAAVRQLQQAELLIVAGTSLTVYPAASLLRFFRGRHIVLINRDATPLDNQADLVLHERVGEVCRHLRPTPLEVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA21</accession>
    <name>R7IA21_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="6">HAT</shortName>
            <ecNumber evidence="6">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Homoserine transacetylase</fullName>
            <shortName evidence="6">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">metAA</name>
        <name evidence="8" type="ORF">BN770_01641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48316">
        <property type="protein sequence ID" value="CDE48316"/>
        <property type="gene ID" value="BN770_01641"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008899">
        <property type="term" value="F:homoserine O-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019281">
        <property type="term" value="P:L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03131">
        <property type="entry name" value="GATase1_HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00295">
        <property type="entry name" value="MetA_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005697">
        <property type="entry name" value="HST_MetA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033752">
        <property type="entry name" value="MetA_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20919">
        <property type="entry name" value="PTHR20919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04204">
        <property type="entry name" value="HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000450">
        <property type="entry name" value="H_ser_succinyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01001">
        <property type="entry name" value="metA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000450-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="317" mass="36547" checksum="511C364FF6F9337D" modified="2013-07-24" version="1">MPIRIPNDLPAASALRSENIFVMTDTRAKTQDIRPLKILLLNLMPTKIATETQLARLLGNTPIQVELELLMVKSHVAKNTSEEHMLAFYKTFDQVCGKTYDGMVITGAPVERMAFEDVEYWDELCAIFEWTKTHVTSTFHICWGAQAGLYYHWGVPKYMMEKKLSGVYRHRVVHKNSILFRGFDDTFMVPHSRYTTVRREDILAHPEMKILAESDEAGVYAISTHGGRQIFITGHSEYDADTLEKEYLRDKAAGLHPDVPCNYYPDDDDTRAPICSWRSSANLLYCNWLNYFVYQATPYDLNRVGIVVMDDFKEQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA41</accession>
    <name>R7IA41_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000098">
        <property type="protein sequence ID" value="CDE48346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48346">
        <property type="protein sequence ID" value="CDE48346"/>
        <property type="gene ID" value="BN770_01666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="28493" checksum="4B14145A5BC98B5C" modified="2013-07-24" version="1">MAEVQQLAAAHFRPVERQQHQPRERQHVHKRARQRLPRFLQVLKHLLVLRLHALLVFHHHAHEVGQGAREGIRVIVRAAQKILHLLTQPNQRLSGQQRIHLLLQFGRKRLHARAVHHVAQPPRALRASKERRVPFRRNDSVKHLRPELHQRQALALRHRNHAMRIQPRQIIRQKAIDVFRGQYFLCVCTAFHFPIPLPQPNTISECKQAKIRCGFFHLAAAKWSARTSKGKTCRLMAHVVSGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA89</accession>
    <name>R7IA89_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="3">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bipA</name>
        <name evidence="5" type="ORF">BN770_01684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000104">
        <property type="protein sequence ID" value="CDE48401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48401">
        <property type="protein sequence ID" value="CDE48401"/>
        <property type="gene ID" value="BN770_01684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="4"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="607" mass="67655" checksum="6026BB25284930B2" modified="2013-07-24" version="1">MVREDIRNIAIIAHVDHGKTTLVDQMLKQGGVYHENQQTVDRVMDSGAIERERGITILAKNTAVHYGKTKINIVDTPGHADFGGEVERVLKMVDGVLLLVDSFEGPMPQTRFVLKKALELKLKVLIVINKIDRPDARCEEVVGEILDLLIDLEADESTIENPILYVSARKGTATLDLDTPGTDLRPLFDAILKYIPAPEGDPDGPAQVLISTIDYSEYVGRIGVGRITRGVFKAGMNVVHTNVQTGVTSQPWRLGNLYQYDGLKRVDAEEVRMGDIVALSGAADLSIGDTVCAPECIEGLPFVKISEPTVTMTFQVNDSPFAGREGTYVTSRHLRARLMRELQTDVSLRVSDTDSTDAFEVCGRGELHLSILIENMRRQGYEFAVSKPRVIYREIDGVKCEPIERLVVDTPQASAGAVIEKIGRRRGTLEHMSGQDRVRLEFLVPSRGLFGYRSEFMTDTRGEGIMSAVFERYEPVKGDIPHRSVGALVAHESGVSTPYALFYAQERGTLFIGAQQNVYEGMIVGQNSRPDDLVVNVCKQKHVTNMRNASASEDAMRLISVHPMTLEECLEFIDDDELLEITPKNLRMRKRILNAGDRARQWRYKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAM9</accession>
    <name>R7IAM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48333">
        <property type="protein sequence ID" value="CDE48333"/>
        <property type="gene ID" value="BN770_01657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="273" mass="29456" checksum="BD0496B589CF84D3" modified="2013-07-24" version="1">MADRLYCALNGTTLRDLDARIHLLDVEELAPAVRTVAARGELAPGGGRVTASRIGGGLHLLRRQREQLSLRVRFLIEEYDIAARHQLLHLVAAWAEAGGVLTLHEDGKRVLRVVCTQYPTMSTLNWLETLSLVFTAFSCPYWEDAAETSFLMPNTSDAPSKLLAVPGDAPETPLNLLIRNIGDAAITTLTISAAGKISFQGLTIAPGAAIRIHHNAGVFAAEMVSDDSTVSILPYRTPDSADDLLLRPGVLNEIRVEAGSAAFVSGRCKGRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAQ0</accession>
    <name>R7IAQ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000114">
        <property type="protein sequence ID" value="CDE48571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48571">
        <property type="protein sequence ID" value="CDE48571"/>
        <property type="gene ID" value="BN770_01728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="50" mass="5831" checksum="DFBA544D7C7B5B22" modified="2013-07-24" version="1">MGHVMLTKCVELWVFGDRITPGMEREIAKAGERAMPIRYFDEDMKEVTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBJ7</accession>
    <name>R7IBJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNF2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000128">
        <property type="protein sequence ID" value="CDE48965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48965">
        <property type="protein sequence ID" value="CDE48965"/>
        <property type="gene ID" value="BN770_01887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036310">
        <property type="term" value="F:ATP-dependent DNA/DNA annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030101">
        <property type="entry name" value="HARP(SMARCAL1)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF3">
        <property type="entry name" value="PTHR45766:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="177"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="353" mass="39739" checksum="6F5536D36B430D67" modified="2013-07-24" version="1">MLPTLPFRSVIFDEIQELRHAGTEKYSAASLLSESCERVIGLSGTPIYNRGGEIWNVINILDYHFLGDWESFSREWCSGYGNQLVLKPDLLGAYLRREGLMLRRTKQEVLRELPPKRRLVQELDWNDKVYAQLMAPVMRDVLRWKQDDQLSAQERAMLEESISQHARQATGVAKAPYVCQFVRALLDGGEKVLLFAHHHQVMDIYKQELKAFSPGFITGRETTLAKMNAVDRFQSGRTDVLCISLRAASGLNLQRATCVVFGELDWSPAVHSQAEDRAHRMGQEDSLLCYYLVAPQGSDAVMQEALGLKVSQFVGLMGDAPQSPEQAEQFANQARRHVERIVAQMGDNSGSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBN0</accession>
    <name>R7IBN0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47912">
        <property type="protein sequence ID" value="CDE47912"/>
        <property type="gene ID" value="BN770_01425"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="5"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="260" mass="29895" checksum="6DDBF568DA4C5548" modified="2013-07-24" version="1">MKHNFHTHTSRCQHAVGTDEAYVEAALDAGFDVLGFADHAPFPFANGFVSGIRMPLDQLPDYIHSVHALQQRYAGQLEIRLGLESEYFPRYHDHLLRMREQGIGYYILGQHYADSEEDNPYIGFECQTDEGVLRYAQSAVAAMRTGLFCYIAHPDLFMRHRTDDQFNHACEEAADMLCQCAKEQHMPIEYNLLGLNSQMEGHTRGYPSAPFWEYARKWHNDVILGVDAHDPEHLKNHRVWQAGIDNVRALGYHLVNDYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBR5</accession>
    <name>R7IBR5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47952">
        <property type="protein sequence ID" value="CDE47952"/>
        <property type="gene ID" value="BN770_01452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447773" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="87"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="204" mass="22211" checksum="4FF088D1EB150B53" modified="2013-07-24" version="1">MNKKYAALFTASVLLLTSLSAAENFPTSQFDYDGWYRPSGTVCPAQDAVATPRPTATPASAPVKTSAPSTGDDYTTPSSQVQEEILLNLLNQERIAQGLSPLTLDAELSRIARIKSADMRDNHYFAHESPTYGHVSDMLKTFGYSFSGAGENIAHHATTEKAHAAFMSSDGHRRNILSSAWQKVGLGIVYDANGYVYVTQIFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC81</accession>
    <name>R7IC81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator RpiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48112">
        <property type="protein sequence ID" value="CDE48112"/>
        <property type="gene ID" value="BN770_00121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="126"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="293" mass="32892" checksum="E733F6BE816406CB" modified="2013-07-24" version="1">MQDMQDMIDRLNQSGKRLSKGHRKIAQYIVEHYDKAVFMTASRLGESVGVSESTVVRFAAAMGYEGYPQLQRSLQELVSHRLTANQRFEMATELDPSAALTTVLKSDMQNLRNTLEQVEQQVFDEVVQRLLNANAVYVMGLRSAAPLAQFMGYYLNYIFDNVHLVSSGATDVFEEIIKLRENDVLIGISFPRYSTRTLEAMRFAKRCGAQVVAITDGPMSPLAEIADLSLTARTDMASFVDSLAAPLSLINALLVTLGLHRKQALSQHFKQLESIWETYEVYLEEEGHGDVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC88</accession>
    <name>R7IC88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000136">
        <property type="protein sequence ID" value="CDE49111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49111">
        <property type="protein sequence ID" value="CDE49111"/>
        <property type="gene ID" value="BN770_01921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021229">
        <property type="entry name" value="DUF2800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10926">
        <property type="entry name" value="DUF2800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="136" mass="15138" checksum="D501D685FAF5928F" modified="2013-07-24" version="1">MAQHDFKLPPTLSDEEIAVILDKLDDLISWAGDVKEYALNAALHGTRFHGWKLVEGRSNRRYTDETAVAQIVSGTGHDPYEHKLLGITAMEKLLGKKQFATLLSDLVERPQGKPVLVPASDKRPEMTNAKNDFANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICB4</accession>
    <name>R7ICB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000126">
        <property type="protein sequence ID" value="CDE48933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48933">
        <property type="protein sequence ID" value="CDE48933"/>
        <property type="gene ID" value="BN770_01871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="440" mass="48116" checksum="6D0B3B861B17C265" modified="2013-07-24" version="1">MAIFDKAKEKFQGFMQGSEQANRNRRSNGGTSGYRPVRNQNTPQPQQEVPAGAFGGGVMPDTMFGGNAGFESVAATGRQNPSGAAPQQTAKHRPFQDLLNRALGKQDKQSGTQRQQPVQPPQQTGNVPYGQGQRFPNNGQNAQGGGNAMNSQNPYNNPQYGMGQRFPNAQNTQSTNAQYNNPQYGTSQRFQSAQFAPQGQPMGASQRYNTGYNQQLNGQLGYTGYQPQGSMGGQTGYHNPPQNYANPPRGNTMSGQPVQGTPVGGQTGYQQPYGMNQPYQQPTGQMNRTQQNAPEQVRGNVSYFPGSFVEEDGTSYRAVLNVVQVTSVSSCYRLIEFLQNNEILLVNAEDISDRMEARRCLDILYGACVVSKCRLTRVSRDTLYIIAPADVKLAAFDGLRRMGEQDIQLNWPYPDNGGFTSSFGGVQANYRTVGGYQNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICR9</accession>
    <name>R7ICR9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ORF">BN770_01630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000094">
        <property type="protein sequence ID" value="CDE48302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48302">
        <property type="protein sequence ID" value="CDE48302"/>
        <property type="gene ID" value="BN770_01630"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE48302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="253" mass="26986" checksum="7D52D1D1F7ED5185" modified="2013-07-24" version="1">MLTKRIIPCLDIRDGRVVKGVNFVDIRDAGDPVEAAVRYNEAGADELVLLDINASYEKRGTMLDVVSRVAEQVFIPFTVGGGISDIDQIRALLRLGADKVSINSPAVRNPDFITESALRFGSQCIVLAMDVKSRAGGGWDVYVRGGRENTGLDALEWAAEGVKRGAGEILLTSMDCDGVGDGFALDVTRAIADEVGVPVIASGGAGKMEHFRDALTVGHADAALAATLFHFGILKISDLKDYLAREGVPVRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICU0</accession>
    <name>R7ICU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49440">
        <property type="protein sequence ID" value="CDE49440"/>
        <property type="gene ID" value="BN770_02020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010697">
        <property type="entry name" value="YspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38440">
        <property type="entry name" value="PTHR38440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06908">
        <property type="entry name" value="YpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="163" mass="18440" checksum="28958442932AF0DD" modified="2013-07-24" version="1">MAAQRGIHRASSAKTADPRCVDFKRRLCNSIEMMILEGYTHFISGGALGMDMYAAEAVLTLREQYPEITLEIAIPHDGQTAKWPQSLRDRAERIREEADVITWIAHEYTKRCLFDRNYYMVSHCSVLLACFDGQAGGTAQTIETAHRLGRLVTVVRPVRRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID64</accession>
    <name>R7ID64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000111">
        <property type="protein sequence ID" value="CDE48522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48522">
        <property type="protein sequence ID" value="CDE48522"/>
        <property type="gene ID" value="BN770_01719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040877">
        <property type="entry name" value="CBM65_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18259">
        <property type="entry name" value="CBM65_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436420" evidence="1">
        <location>
            <begin position="29"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="CBM65_1" evidence="2">
        <location>
            <begin position="254"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="CBM65_1" evidence="2">
        <location>
            <begin position="374"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="CBM65_1" evidence="2">
        <location>
            <begin position="494"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="603" mass="63771" checksum="5EC8613253D29386" modified="2013-07-24" version="1">MFKEVIQVKKVVSVLLAAGIIATTGAFAENVGVSSPAVSPVASPVAGAVSSIIDFADGNFGFLGMDTTLGNADASELSVVDYNGGKALCVSPAAAGRVPYVSLNVEGLLGENLSRLAKITFDVGVELGTDGKFYAQSGKVYMVNGEDSSKQSADWSVYMERKNPKTAVVTVPAGAFVAGRGDTLQFSKEVDSFIDSKKFDGEAPRDFYVTNIQFFDAEGNVLPVDTTAEWVAPVTEEDRSYLYDVANAVEFPNFAYEGGGWSQDGAEMPQEFLDALVPGSVIEISYESEDGTMWIVLPDAAAGWSRVANDGSAAINSSKNTCQITYEQIAAVCGEDKSTWGARLQCEAGSAWKVYSVKVGQKVARKVATPVASFDGFACEGGAWSQNGFDIPENVLDALVPGTALQIDFESEDGSMWIVMPDCTAGWMRVAQGAASISGGKAYITYEQIVEACGEDKAGWGARMQCEAESAWKVYAVSVVKLAEMVGSHNNVEFEGAACEGGAWGQNGTEMPENIVAALVPGAVINISYESETGNIWIVMPDAAAGWSRVQQQTAATDGKTAQITYEQIAAVCGDDASTWGARMQFESDGAWKVYAVTVGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDF4</accession>
    <name>R7IDF4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RND family efflux transporter MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49328">
        <property type="protein sequence ID" value="CDE49328"/>
        <property type="gene ID" value="BN770_01975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447860" evidence="1">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="302" mass="31741" checksum="2BA9D270132B5417" modified="2013-07-24" version="1">MRKKQVLQLLTMLTATAAVCGGLFLRHQPMEVAAVRVEKGNICRTVGVAGTVCYTQETPVTAMVSGMVDALYVIEGERVTQGQALARISGGTAQEQAVLALMTHLDDDGRSALTQTLAEGSVLRAPVSGIVQRVATAAYAPVQAGSIPMTIAAGAPEIVCLCVPADAEDVRVGQLADISTNGKHCGYATVASIKPMIAESSSAYRLILTPQDGLTLSPGIEVEAQITAEYHAQVTTLPLSAITPDETVWWIADGICTEIPAQIVQTDENSAWVSLPEGISVVNGEFDRCQQGVRVRIAEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDQ4</accession>
    <name>R7IDQ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">topA</name>
        <name evidence="13" type="ORF">BN770_02046</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49576">
        <property type="protein sequence ID" value="CDE49576"/>
        <property type="gene ID" value="BN770_02046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="166"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE49576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="708" mass="80363" checksum="F77C056BE42CF643" modified="2013-07-24" version="1">MTAAKQKLIIVESPAKARTISKFLGKGYKVEASQGHVCDLPKSQIGVDVDNDFALKYITIRGRGEILNRIRKEARTASQIYLATDPDREGEAISWHLSHVLNMDPSQPCRIEFHEVTKKAIQNALKSARPVDMGRVDAQQARRVLDRLVGYKISPLLWAKIKKGLSAGRVQSVATRMVVMREEEIEAFIPEEYWEISAKLLAHQAHGRKLHFTARLATLDGQKAVIANAEEAQKAVERIQKAHFAVNSIKMSEKRKMPAAPFTTSSLQQEASRKLGFTTAKTMQVVQQLYEGIDLEGEGTQGIVSYIRTDSVRISDEALNALREYIPERFGSDYLPEKPNEYKGRKNAQDAHEAIRPTDVHRTPDSIKPSLTKEQYNLYKLIYNRFLASQMMPALYETMTMEISGDGVGMRFYGEHKKFAGFTSVYEESTDDDVASSETTLPQLSEGDAVAVADVASEQHFTQPPSRYTEASLVRMMEEKGIGRPSTYAPTITTIISRGYVSREKKRLYPTELGRMVTSMMETYFEDIVDVEFTAELEDKLDKVEEGEMDWKQILRDFYPPFEQTLKLAEQQIEKVEVKDEPSDVPCDKCGAMMVYKMGRFGKFLACPNFPECRNTKPIVTYIDAPCPKCGARLMEKTSRKNRKFYGCERYPECDFVSWEKPVTEKCPVCGSYMVEKRGRKGEVWHLCANETCHHRIEVQASEEEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDT3</accession>
    <name>R7IDT3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type sugar transport system permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49989">
        <property type="protein sequence ID" value="CDE49989"/>
        <property type="gene ID" value="BN770_02221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="303" mass="33718" checksum="154A48D17F92E672" modified="2013-07-24" version="1">MTAISTQAHICPEKKKKLGVGQIILIIVMMLFVLICTLPFINVIAMSMSSKSAILRGAVSFWPVEFNVDAYKLIVSDNSMWHSLLYTIELTVIYTVLAMVMTILVAFPLSMRRLKGQRVIMFFIVFTMYFSGGTIPIYLNVKEFGMLDSMWSLIIPGLISTFNVIILKNFFSSLPYELVEAASIDGATDFQVLTRIFLPLSFSSLATLSLFYAVGKWNSFNDALYYITSRDLQPLQLKLYNLIKGSQSVEVAVTEGSSNDLSTSVSESIQSATIIFATLPILIVYPFVQRYFVAGVTMGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDT7</accession>
    <name>R7IDT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49994">
        <property type="protein sequence ID" value="CDE49994"/>
        <property type="gene ID" value="BN770_02224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="390" mass="42594" checksum="2B7E3DC1CB8EE9F2" modified="2013-07-24" version="1">MEKIRLGIIGIGNMGSEHCRLILSGQTPEIALTCVADPRQDRRDWAQQTLPAGTGIYADGMSLIRAHACDAVLIATPHELHPPLAEAALRAGLHVLSEKPAGVYTAQLHPVIAAAQETGRTYALMFNQRTNCVYRRLKALLDSGELGALKRVTWVVTDWYRSQAYYDSGAWRATWTGEGGGVLLNQCPHQLDLLQWLCGLPTTVRAFCHEGKWHDIEVEDDVTAYLEFPGGATGVFIASTGELPGTNRLEIACDRGKVVCENGQLTLWRLPQSESAYYRRSASAYPHAEVQVEILPLDGENPQHVGVLNAFAAHILHGTPLVADGAEGIRALMLSNAMHLSSWTGKPVSLPIDEGEFARLLAEKRLHSRKKQVKEVTFATDHSGTGRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDU1</accession>
    <name>R7IDU1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YceG_bac domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49999">
        <property type="protein sequence ID" value="CDE49999"/>
        <property type="gene ID" value="BN770_02227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025647">
        <property type="entry name" value="YceG_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14266">
        <property type="entry name" value="YceG_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceG_bac" evidence="2">
        <location>
            <begin position="51"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="35304" checksum="589CB019BE125CFC" modified="2013-07-24" version="1">MANRINASNLSDLLLPMRQRGNAPGVYFVRLCQWSPEIKDFLWRYHEAARAKGVIIEGQIGNPDERQLSYLTEMLGSAFEPNPAFITQALQKWMPRMSQANRVSFAEAMCDQMDELKRKGKTDSIIRNIYMKVMCWLYYKFERLMPFLGDDNPPRILYECNAVTAHELILLRILSLMGTDILLLEPQGDAAYLKQDAASAWSQLLSVQGMPFAKDFTLKQFRKEMAAAAAENMRQPSQPAPRPVTSAQPMRQPAPAVPRPAIAPNQPMRTPPPAGPPRRGPDTSAARCAAAARPRNILPEAVADGVHECVDEGSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDV4</accession>
    <name>R7IDV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux transporter RND family MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49626">
        <property type="protein sequence ID" value="CDE49626"/>
        <property type="gene ID" value="BN770_02058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447872" evidence="1">
        <location>
            <begin position="21"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="354" mass="37628" checksum="ACB4CBCA941DB1C3" modified="2013-07-24" version="1">MKKLFALLLALALVGSIALADPASLTDCSVSSGVVNAVNYIDITAPFSGTLQPFTWEAGDLVNAGDLLFSMRTITIYATEDATVQAIYCAAGDDATAVATRYGGLIAMRPESEWVIAGSITTAYDKRDNRVVDVGETLYFRSNKEGRSVGTGRVTMVSGAEYMVEVLTGEFEPGEILSLFRDKNRTASDQVGRGVVNRRDTLTAVGQGRVAEVLVKVGDQVKNGTPLLRLMPTATTPDASPDITAAQNGVIGTLAVQPGQQVYEGQLLARLMLVDKLEVVAQVDEVNLKNLYVGDKVSVTLDMDESNVLTGTVTEIGNLGTTVQNAAYFPVHVELTTNQIPLGASASVYIPNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE74</accession>
    <name>R7IE74_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49623">
        <property type="protein sequence ID" value="CDE49623"/>
        <property type="gene ID" value="BN770_02056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25593" checksum="B30258DF5970FF76" modified="2013-07-24" version="1">MSYISFEDVCKDYPAGNTVVHASDHVNFHIEKGEFCVVLGPSGAGKTTVLNLLGGMDKATSGRIIVGDKEITGLRSPQLTEYRRHDVGFVFQFYNLMPNLTALENVELAQQVCERALDPREVLEQVGLGERMNNFPAQLSGGEQQRVSIARALCKNPALLLCDEPTGALDSKTGEQVLDLLTRLCHDYSTTVVIITHNASIAPLGNRLIRMRNGSVQEMTVNEHPAKVADITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF31</accession>
    <name>R7IF31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49938">
        <property type="protein sequence ID" value="CDE49938"/>
        <property type="gene ID" value="BN770_02199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183:SF1">
        <property type="entry name" value="PTHR47183:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="260" mass="29509" checksum="AF8EBC27DC96B3D2" modified="2013-07-24" version="1">MKVVILAGGFGTRISEESAFKPKPMIEIGGMPILWHIMKTYSAYGYNEFVICAGYKQHVIKEWFADYFLHTSDITFDYTHGTNEMIVHNKHAEPWRVTVVDTGLNTQTGGRVKRIREYIGNEPFMLTYGDAVGDVNIAELVAFHQAHGKIGTMSMYNFGQNKGVVEVGANSVINAFREKSDIDGDLINIGFMVFQPELFDLIEGDETVFEKGPLTKLVAQKQLVGYIHQGFWQCMDTLREKQKLEQLWASGNAPWKVWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF32</accession>
    <name>R7IF32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50061">
        <property type="protein sequence ID" value="CDE50061"/>
        <property type="gene ID" value="BN770_02262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="116" mass="13064" checksum="39E4B440563649F6" modified="2013-07-24" version="1">MPNTGRNYRHPPAIHHIGRRDENHAQTVRQAAKVVRLPDRATKLLTFYADCPDGFRPALKTVRENTGIAKNAVSTIRKCLVTAGFILYGGGNICRLWDRIEEVARIEKLLNASNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFI6</accession>
    <name>R7IFI6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50370">
        <property type="protein sequence ID" value="CDE50370"/>
        <property type="gene ID" value="BN770_00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435831" evidence="1">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17502" checksum="FA6439BD18E5F0D0" modified="2013-07-24" version="1">MKKFLCAILFLTMVISLSACGGKGVSTLVKHYGQEKVDEMEIECTDETQLKVANDLIAEAKDIMSYCGSGDGTNKEDCGALERYYFFDDKAVRADVSIELVTTKQENGKGYIWVKYSADYYDKDDTLISGNGEAYSRWDIEQLDGKWTVTLIDEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFN1</accession>
    <name>R7IFN1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ORF">BN770_01991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49382">
        <property type="protein sequence ID" value="CDE49382"/>
        <property type="gene ID" value="BN770_01991"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="260" mass="28835" checksum="246197EE118174A5" modified="2013-07-24" version="1">MGAMPASRYAFGSVPWYSVLIVSAIVIGLSLCSHEQKRLKLPADLAIDLALCLIPSAIVGARLYYVAFSWDVFAADPLRILRIWEGGLAIYGGILGGAIALLLFCAVRHMPLLQLADVLVPALALGQGIGRWGNYFNMEAYGRLITNLQWQFFPVAVLIPVDSGYEWHMATFFYESCVDVLIFLVLWFGVRKRKRWNGQLLAVYMLMYGIGRAAIEGLRMDSLYSGSIRISQIVSITLAAVGLIWLLIGTFARKNPQREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG31</accession>
    <name>R7IG31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50421">
        <property type="protein sequence ID" value="CDE50421"/>
        <property type="gene ID" value="BN770_02379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="34"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="350"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="590" mass="66063" checksum="13A247990E7501E6" modified="2013-07-24" version="1">MAKQENRNTLSTSVLVRRFLPYFRKYRKTMAFDLCCAALTTVCELVLPLIVRTITTRATYDVASLTVPFVLMMGGVYMLLRVIDAAANYYMQSIGHIMGSQLETDMRHDIFHHLQELSFGYYSDTKVGQIMARITSDLFEITEFAHHCPEEFLIAGVKILVSFIILCTMNIPMTLMMFAVLPFMLYFAKRFNTKMRQIFKERNKQVGEINAQVEDSLLGIRVVKSFANEEIEEKKFADGNAKFLDLKAQSYRVMAQFGTSNRIFDGLMYIVIVVGGALFIKAGRLSAADFMAYLLYANVLLNSIRRIVEFTEQFQRGMTGIDRFLEIMDAPAEIVDAPDAKVLTDVRGEVAFDHVSFHYQDDDAEVIHNLNMTVRPGQSIALVGPSGAGKTTLCNLIPRFYDVTGGCIRIDGQDIRTLTQKSLREAIGMVQQEVYLFAGSVLENIAYGKPGASRAEVEEAAKLAGAHEFISALPHGYDTYVGERGVRLSGGQKQRISIARVFLKNPPILILDEATSALDNESEHIVQQSLEKLAKGRTVFTIAHRLTTIKGADCIWVLTEKGVEEQGSHTELIAKGGLYAHLFAMYTSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGM2</accession>
    <name>R7IGM2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_02414</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50483">
        <property type="protein sequence ID" value="CDE50483"/>
        <property type="gene ID" value="BN770_02414"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="193"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE50483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="320" mass="35398" checksum="BCDB1E6E18A2B4E9" modified="2013-07-24" version="1">MRIIRDPKRLNPCVLVLGMFDGVHRGHQALLMRGDELAQEMVYPLAVCTFQPHPLMVYPLAVCPFQPHPLHVLAPEKEPVMLTTLPEKAAVMQSFGVDGLCVTTFTRARANQSPEDFMAELVEVYAPVVIVCGFNFTFGAGGKGNGQMLKEYGKKHGFRTVIVPEVVIDGETVSSTRIRRLLAQGDMHEVNNLLGRGYSIAGRVEEGKQVGRTIGFPTANITIPPHKALPAFGVYACYLETSGGIFPAVVNVGRHPTLPEGHVTVEAHVLDEFLSLYGRNVRLTFLKFMRPEQKFDSIETLRAQIAHDADDCRAYFAQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGQ5</accession>
    <name>R7IGQ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49737">
        <property type="protein sequence ID" value="CDE49737"/>
        <property type="gene ID" value="BN770_02112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="224" mass="23800" checksum="CEA71AAC450302CD" modified="2013-07-24" version="1">MEQYPKKLPPQVDSRLRHSILEMPIEIRKASGIVIYGRRIKSLVFTTDLAIIKNCDADAVFAVYPFTPQQSISDAIIKASYIPVFCGVGGGTTQGLRTVSLAKDAEAQGAMGVVLNAPVSNLNLLAVSKAVDIPVIITVIDEVTDIGQRIASGASILNVAGGANTPAIVRKIRTEYPDFPIIATGGNKPDTIAATVAAGANAITFTPPSAQELFKAMMTRYRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGT3</accession>
    <name>R7IGT3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplO</name>
        <name evidence="8" type="ORF">BN770_02435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50548">
        <property type="protein sequence ID" value="CDE50548"/>
        <property type="gene ID" value="BN770_02435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="146" mass="15161" checksum="6945C21FC2362452" modified="2013-07-24" version="1">MKLHELHPAEGSTTAAKRLGRGVGSGLGKTSGKGHKGAKARSGGGKRPGFEGGQMPLYRRVPKKGFTNIFGTDYATVNVENLNVFEDGAVVDAQALIDAGLIRKAQDGLKVLGNGELTKKLTVKAAKYTASAKEKIEAVGGTAEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH07</accession>
    <name>R7IH07_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA methylase NOL1/NOP2/sun family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000153">
        <property type="protein sequence ID" value="CDE49857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49857">
        <property type="protein sequence ID" value="CDE49857"/>
        <property type="gene ID" value="BN770_02166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027391">
        <property type="entry name" value="Nol1_Nop2_Fmu_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031340">
        <property type="entry name" value="RsmF_methylt_CI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13636">
        <property type="entry name" value="Methyltranf_PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17126">
        <property type="entry name" value="RsmF_methylt_CI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="12"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="106"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="442" mass="48450" checksum="1494B80B6693F035" modified="2013-07-24" version="1">MTELPQAFLSQMAAQLKGEMAAFLRTYDEPYQRGLRVNPWKRPTLLPEDCGERVPWEENGHYLALTSTAGADVLHEAGAWYLQEPSAMLPAAVLNAQPGEHVLDLCAAPGGKSTQSGLRMGGQGVLVCNEPVWERAKILSQNIERMGIPNALVVSAYPDQLAQRWPEAFDAIQVDAPCSGEGMFRRHPETRAEWSPESPAGCAKRQAEILDRAAKMLRPGGRIVYSTCTMNRTENEDTVDAFLSRHADFSAEAFSLPGADAPDGMLTCYPHRMKGEGHFVALLRKHGDAPCNWQKAPEKDAPSKDALQALRAFCPTANANVMRTGSGKPGRSRDESVTLSCLPDRPACDGIQVVRCGLQLGTVQKKLFVPDHAWAMSIFPPDVPRVELTREDARRYQAGETLPADGKGWALACCDGIPLGWGKISDGQMKNHYPKGLRRPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7II00</accession>
    <name>R7II00_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="12" type="ORF">BN770_00422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51414">
        <property type="protein sequence ID" value="CDE51414"/>
        <property type="gene ID" value="BN770_00422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="219"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="587" mass="67558" checksum="9B8C24FE2C0F63F5" modified="2013-07-24" version="1">MKIIYNDGHVDECPADDELHVIRHTAAHILAQAVKHLYPQAHFAYGPATEKGFHYDVDLGDVKLSDEDLKTIEKEMQAIVKQNLPIKPFALGREEAIKLMQERGEIYKVEHIGDLPEDATLTFYQQGDYIDMCVGPHLCYTKALKAFKLTALSGAYWKNDKNNKMLTRISGIAFRNQEELNEYLKMMEEAEKRDHRKIGKEMGLFMLCDEGPGFPFFLPKGMQLKNALIDYWRDIHYAADYVEVSTPMIMSRHLWETSGHWDHYKDNMYSTKIDDEDYCIKPMNCPGGVMVYRSQPHSYRDLPLRVGELGLVHRHELKGALHGLFRVRCFTQDDAHIFMTREQIPDEIAGVVHLINQVYSKFGFDYFVELSTRPADSMGSDEDWEDATNGLKTALEKLGMPYIINEGDGAFYGPKIDFHLRDCLGRTWQCGTIQLDFQMPLNFNLEYVDVDGSRKRPIMIHRVCYGSIERFIGILTEHFAGKFPTWMAPVQVKVLPVSDKSMDYAKTVYAALRAKKIRCELDDRNEKIGYKIREARQVDRVPYMLILGGQEVENNTVSVRDRATDQTVTCTLDEFIAKISKEIADRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7II44</accession>
    <name>R7II44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000223">
        <property type="protein sequence ID" value="CDE51469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51469">
        <property type="protein sequence ID" value="CDE51469"/>
        <property type="gene ID" value="BN770_00456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="66" mass="7366" checksum="BE5E69BC848445B7" modified="2013-07-24" version="1">MRLTPRKGNGGHITAYFATVGSKEARDAGFIRPDGNSRILKKVVDTEKGTLTFQVDWEAEENRTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7II65</accession>
    <name>R7II65_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51295">
        <property type="protein sequence ID" value="CDE51295"/>
        <property type="gene ID" value="BN770_00363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="154" mass="16939" checksum="B5E695DDDCF6A323" modified="2013-07-24" version="1">MLLPAAVRPYAADVDGTDSRVRCAIVLNGSKELRIQLCGRLKRGLFGRNQLLADGDVLCVALHQPDGDVPLFDSRCDGYANVLDDRQSPAPIPLHPAICPKCRNAAFQVDLSFEYPDAEEVSAFANPGDAFTWIWISMRCTRCHAVFRGDFTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIE4</accession>
    <name>R7IIE4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51390">
        <property type="protein sequence ID" value="CDE51390"/>
        <property type="gene ID" value="BN770_00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="311" mass="33962" checksum="6D090DFC087DEC29" modified="2013-07-24" version="1">MTQMMPDALESRTISIPGDGRRLDVALSEAAGLTRSRVAALMADGNVTVDGKVETKSGAKAKQGQIVILTIPAPKPAVPVAQEIPLTILYQDDDLAVVLKPCGMVVHPAAGNEDGTLVNALLHHLDHLSGIGGELRPGIVHRLDKDTSGLLLVAKNDQSQLALSRQLQERQMEKHYRALVEGNLREDSGRIDQPIARSKKDRKKMAIDPEGRPSITDWTVLARGRNVTLLDVHILTGRTHQIRVHMKSIGHPVCGDPIYGSGRGVKVPRLMLHAYTLSFTHPRTGERMTFTAPLPEEFVQGLRGNGVEWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIG9</accession>
    <name>R7IIG9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51425">
        <property type="protein sequence ID" value="CDE51425"/>
        <property type="gene ID" value="BN770_00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="224" mass="23942" checksum="5B2CB0A746E2948A" modified="2013-07-24" version="1">MPLLPALRAFFTRLLTDVDDALFPQHVFCLTCGALSLPNAICPACLAVLDDLRLPSDALAPNAAAVWSYHGIARQLVLMLKYSGIAECAQVLADGMASACPFSLPPDTVVTSVPMTKKHLDARGIDHGRLLAEAFAQRRNLPYQPLLIRTRETATQQGLNAAQRRKNLHGAFAAAARISTPVLLIDDVYTTGSTTETCADALRAAGAPDVFVLTALAVVPDEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIL4</accession>
    <name>R7IIL4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I restriction enzyme R protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50432">
        <property type="protein sequence ID" value="CDE50432"/>
        <property type="gene ID" value="BN770_02387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="517" mass="59826" checksum="4B78B920D21981D2" modified="2013-07-24" version="1">MNHYLWSLYLQAGGQTIVERFTAFETGDREKFAAFIRSLMQAYCPDAALIDDVAIDIDDAISALNESEEISKNEELSADKDSNLRNNPDYYEQVANNLWQTLSELLYNEVQDIGKVTDKEIFHVFCDNIVYFSVLDYAESPDMIPYFFPRLYNVLSSIAETFEIKLPELPSRRAYKDRFALYYNLNAILKAYREEQSWSPAELCAFLYDFAPKFVGGTNWIWPKLPEPSAAFVIGAPPDADEWLRKGCKENSFAWQGNPETQPGDVILLYQWTPTSAFTSIWQATAPGFIDPLFWYYRCIYFGRPVYVQPLTFRELRDDPILGKIPLVKAKMQGMNGTALKPSEYNRVLECLDSKGNDTSFLPKLTEHYTAADAEIRIERDVEKQLLEPLLERLGWTRAQYVRQMPLRMGRGSTVYPDYVILPQFTPNYEKGYWIVEAKKSISNDKQLHVDFGQAISYAYRLNASGIMLVAQEGIWLSEKTTDFKKNSYYTWEQMQEDDLFLQVYKVCGNRRRKGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIL6</accession>
    <name>R7IIL6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EDD domain protein DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51291">
        <property type="protein sequence ID" value="CDE51291"/>
        <property type="gene ID" value="BN770_00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="283" mass="30997" checksum="53E818CB9E4C65D9" modified="2013-07-24" version="1">MVKIISDSTSDLSQDLLDRYNITLVPLIVRLGDQQYEDRVNITSEEIFRWSDSTKKAPTTACANVWTIQEVFQKYLETYDEIVAFSISGKMSATGANMVEAAAELGASDRIHVIDSQSLSTGIGLLVMEAAVMAQDGKSAKEIVAHVTSLIPLVRASFVVDTLTFLHRGGRCSGAAALMGSMLKLHPKIVVRDGQMLVDKKYRGSLARCIPAYTHDLHDDLLRARPERVFITHSGCDPEVVEQVRTYLTSLNHFDAVIETRAGGVISCHCGPGTLGVLFILKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIN3</accession>
    <name>R7IIN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000198">
        <property type="protein sequence ID" value="CDE51163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51163">
        <property type="protein sequence ID" value="CDE51163"/>
        <property type="gene ID" value="BN770_00306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="3">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="4">
        <location>
            <begin position="292"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="377" mass="42480" checksum="8AE2381BD1D9BC25" modified="2013-07-24" version="1">MVKVNIISGFLGAGKTTLIKKLLTGSVAKEKIILLENEYGEVGVDGSFMKDSGIIVDELNSGCICCTLVGDFQKAVDDLIAKYHPDRLLIEPSGVGKLSEILAAVERAKERHSDLVVTGCATVVDAGKCRMYMKNFGEFFLDQIKTSATVIFSRTQLLSAERIEKSRALVEEQHPGVRIVTTPWDDLSADTLLEVIESGKPMEIHLDDDDDDDDEDEHEHHHHHEDGEECCCHHHHDDDHDEHEHHHHHDHDDHDEDEHEHHHHDHEDGETCSCGHHHHHHHGHDADEVFVSVGVETANRYEQDEVKAMLDKLSDEEEYGTVLRAKGVLQNAAGEWFQFDYVPGESQFRPGTPDYTGRLCVIGAHIDEKALRELFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIW3</accession>
    <name>R7IIW3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="11" type="ORF">BN770_00496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51575">
        <property type="protein sequence ID" value="CDE51575"/>
        <property type="gene ID" value="BN770_00496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="138" mass="14724" checksum="29BE099B0BC73D6A" modified="2013-07-24" version="1">MKKFIEEFKKFALRGNVMDMAVGVIIGGAFTGIVTALTTNFINPLLSLIFTGGPGDISDGVAWTFGAAFASFLTTVVNFFITALVLFMLLKGINALMSIGKKPAAPAAPTTKKCPYCLSEIPIKATRCPHCTSELDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ06</accession>
    <name>R7IJ06_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rny</name>
        <name evidence="8" type="ORF">BN770_00528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51625">
        <property type="protein sequence ID" value="CDE51625"/>
        <property type="gene ID" value="BN770_00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="353"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="537" mass="60695" checksum="440737A8486F558E" modified="2013-07-24" version="1">MPTIVWILIVLLVGAGGGFAGYTYRQKMVEEKINRSEETAKRLYEDAVRKADDYKRKADDYKKEKVQEAKAEILKAKDEIDREKADNNREMNEIRERRAEVQRSENRLVQREASLDKRSDSLDDRENDLKKRSDLMERKQEDTARLHDEAEALVTKQNTELERIASMTQDEAKQIIIDRVQKEAFHDAAASVRDIEARAKEEAEKKARNIIALAIQKCASDHVAESTVSVIALPNDDMKGRIIGREGRNIRALETATGVDIIIDDTPEAVIVSAFDPIRREIARLTVERLINDGRIHPARIEEMVEKAKKEVENQIREAGEAAVFETNQHGIHHELVKLLGRLKYRTSYGQNVLKHSIEVSHLAGLMAAELGADVQLAKRAGLLHDIGKAVDHEAEGTHVTLGGELARKYHESPDVVHCILAHHNDVEPQTVEAVLVQAADAISAARPGARRESLENYIKRLEKLEEIATSFPGVEKCYAIQSGREVRIMVKPDDVTDDGTKILAKEIAKRIEKEMEYPGQIRVNVIRETRSMEYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ71</accession>
    <name>R7IJ71_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exonuclease SbcCD C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000214">
        <property type="protein sequence ID" value="CDE51343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51343">
        <property type="protein sequence ID" value="CDE51343"/>
        <property type="gene ID" value="BN770_00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118306" checksum="4F92CA9F9585A4CD" modified="2013-07-24" version="1">MKPIRLTMQAFGSYGEKTEIDFPKGGDFFLISGDTGSGKSTIFDAMMFALYGEVSTNGSGKENELLSQFVDVRNDKPVVSLVFTAHQHGQEETYKITRTPRHIRPAKRTGAKQQEEGETAELLMPDGSQYPSKLSDTNRKIEEIVGLTADQFRKVVMIAQGEFMDFLRAGSKEKTELLRDLLKTDYYYQLSERLKTLAKEKNTAAKTQRANMSFFAGRAVTEGLPEEDALALEAAKGTVITAKELQPEQVDTLAEVLSGVCARLQLQQGELAQQQTAAQNDRDECMKRIEAAQPLMKRFEELESAEKALQECAAQADEIEEKRGLIGKIRDAWAIEPKYQRMKDAQKALTDAQRELAAKQQELPQLKQTAADAAALHQQMEKTKDAATTQCAEVETKVEKALETFDALEKAEKALRQAEEADTKAKADAESAKKALDGFKNQEDAWRKQEAELQGAEAAYEVCKQQNQQYRDLKKSLEDLHGNQKDVQEKARQAAAAKDAYASATQKYQRAQNEYDDYRLAFLNAQAGLLARELAPGKPCPVCGALEHPAPCQLTQENQQLNREQLERRRKAADDAAKAQEEKAKESESAQVKLTERQKAAEEAERKLVENAKNIRENVPMATAADVEAMLQAWLPELQSASKSVQAKVDALKKVRENLDGAKEKREQLEKAAADAQETAKSTENEKTTAATALDIHKKELSGGAYRTREDAVAQRTQAKEAKQKAEAAASQAAGKERQAQKTETECRARIQQLDAEMPKKQADAEEFNQQYQQTMAEKSLDEAQWQALTANYDAEEPDRLQKKVNDFDQKKNTAETRCTMAQSAIAGREKPDMAKLEVASKAAESALKEVSNALEAAKHLRLNNEKVLEDLREGREPLANACKAANTAQHLSDVMAGTESGNRMNLETFVQRNYMEKILCDANRRFRDMSNGQFELKLINVEDAGEGKNKGLDLEVYSIVTGKTRSVNTLSGGESFMAALSLALGMADQIQAATAAIHLDVMFIDEGFGSLSDNARNEAVNILKEMAGKQRQIGIISHVSELKDEIENQLIVKKDDRGSHISWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ75</accession>
    <name>R7IJ75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC-type DNA-binding domain-containing proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000214">
        <property type="protein sequence ID" value="CDE51348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51348">
        <property type="protein sequence ID" value="CDE51348"/>
        <property type="gene ID" value="BN770_00390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="197"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="297" mass="34721" checksum="5A3BA7069A997DAB" modified="2013-07-24" version="1">MENNNELKIITDETLMEKRNHGQPAFPFQYYLEDIWDFDFHTLGWHWHQEIEFVYVQSGEAHCCVGKDRFSLPAGSGLFINTKILHQFTAEHPTVIPNIVFSPVLLASPESFVYQQYVKPLLVSDIPYLVFEPLSLWHKEILSLLNQVFKTQEQPNFRELTTLRLLTSIWEVLYENMESRLQQGQPVKRDLNASRLQMMMSFIHSHYADQISLADIAIFAHVSNNSCMQIFKNGIRQSPVSYLIQYRLKKAAELLANTEMKAAVISEECGFHDVPYFYRKFKEIYGISPIEYRKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ87</accession>
    <name>R7IJ87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51824">
        <property type="protein sequence ID" value="CDE51824"/>
        <property type="gene ID" value="BN770_00634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="351" mass="38088" checksum="CE1D7FE022B0FF1B" modified="2013-07-24" version="1">MRKKIIICALSVFLLILSGVLAFYLHGQNRPIAGLSGDNRTLLRVWMLHSPGGAARWVETQLSAYERQHPGVLIYLRQVSADELTAEENLLPDVVLYRPGDIPDPDGLFLPISGDAPIFAGLLSGGRQVAYPLCWGAWVLAVDSAYDPQTAATPAPTTLLGRPSSTLSPEQTPALFPLEKADAANCPLLSPGGCALYALREIFANQAYPRWTDDFAQLSSDAVYQRFRERKCASAMLTTGQVVAFSGLTSAGKGFPFRVMVGRTVTTEQVLLSSICAGAQDGAADLLSFLVSRGAQEQLVHQGLFSVREDLALYPSGWAAEVEQAARRGITMPDAFQSDEALRQKAWQDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJC2</accession>
    <name>R7IJC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000218">
        <property type="protein sequence ID" value="CDE51403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51403">
        <property type="protein sequence ID" value="CDE51403"/>
        <property type="gene ID" value="BN770_00415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="PTHR35339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="378" mass="42662" checksum="1F771AB5E992FDE0" modified="2013-07-24" version="1">MEARAYWLQTMLKIADPVLKNLAAGTLKQNMPMMFHPDRAEYMHLEALGRTVCGIAPWLELDGLTGEEAEIQTEHRELTRKAIANAVNPESPDFMNFTEGYGQALVDAAFLAHGIVRAPKQLFRALDEQTKRNLVGALRATRKFTPFVMNWLFFSAMVEAALRVMGESDYDLTRVDYAVNMFESWYLGDGVYGDGPKFRWDYYNSFVIQPMYVDVLRTFADVGRGYDELLKQVEHRAGRYAAELEKNINADGSYPVIGRSITYRFGAFQLLSQAALEDFLPNELPPEQVRTALTACIRKVTEHPAMFDARGWLQPGVYGCQPDLAEGYICVGSLYLCLTVFLPLGLAPTADFWSKPEIPWTAKRIWSGENVALDHAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJD4</accession>
    <name>R7IJD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heptaprenyl diphosphate synthase component I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51879">
        <property type="protein sequence ID" value="CDE51879"/>
        <property type="gene ID" value="BN770_00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014535">
        <property type="entry name" value="Hpre_diP_synt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010898">
        <property type="entry name" value="Hpre_diP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07456">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027391">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="171" mass="18378" checksum="2B2B668638D537A0" modified="2013-07-24" version="1">MNKQRITTKQLALCSVLLTLMLVLGWVESLFPPLMGVPGIKLGLSNGVLIFAVYMLSLPTAWVLMLLKVVLSSLFLGGVAALPYALAGGVLSLASMCLLSRVKWMHPVTVSIVGGVMHNVGQIVMAMIILHTSQLAYYMAVLMLSGILFGALTGVSATLVMKHMKHIKWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJH2</accession>
    <name>R7IJH2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPgrasp_ST domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51929">
        <property type="protein sequence ID" value="CDE51929"/>
        <property type="gene ID" value="BN770_00697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039523">
        <property type="entry name" value="RimK-rel_E_lig_ATP-grasp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14397">
        <property type="entry name" value="ATPgrasp_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPgrasp_ST" evidence="1">
        <location>
            <begin position="78"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="335" mass="38056" checksum="5C930F88027BF208" modified="2013-07-24" version="1">MSRLSYFFKRLFKMDWKAMWKTAGLLHERSGKSRIWLLCDMLRCAVKYNAGYVDYKIAQMYKLNDAQRKTVITRGISNDIVRRMNDKAYWHFFDDKTQFNELFKEWIPRKWLLINADTPLDKLEDMMTLPALIGKPLEGSSGQGILKFTPEDWKGGAKAFHQLLMDKNIGILEEIVVQHPEMARMCPTSVNTCRIATLLGDKKQGIVYAFLRIGNGKVMDNVDCGGMAARIDLESGKLLTVGADKAGNTYTKHPITGTDIIGFTIPYWEEAKKMCLDAAQKVPQMRFVAWDVAITPNGPTFIEGNSFPSHAVPQFAAHYPDGIGILPEFRKFIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJQ5</accession>
    <name>R7IJQ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50812">
        <property type="protein sequence ID" value="CDE50812"/>
        <property type="gene ID" value="BN770_00211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="295" mass="33560" checksum="720D8938588E1CA0" modified="2013-07-24" version="1">MRLSTSTCMYFNRPDGTKASILDSVRTLGQAGYRVLDMNFHDLSVFDTPFKTPQWETLIHQAKDIADEMGIEFSQGHLHFYNFCDPNTPDKEFLDELIRRGIEGGRILGIKWLVIHAATDFDSVTPVRDSKRKTIEYLKPRIELAGKYGVGIAVENLWEENIAPKRRYCVTAEELGDLVDSLPYDNVGCCWDVEHASICHQDQRKALQYLGKRLKATHISDYNSIKNDHILPFSGLSDWTEITDALRLAKYDGDFTYETHNFTAKMPDEVIMSGLKHSIDIGNLLIDMIQGGHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJT0</accession>
    <name>R7IJT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51875">
        <property type="protein sequence ID" value="CDE51875"/>
        <property type="gene ID" value="BN770_00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448035" evidence="1">
        <location>
            <begin position="25"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="213" mass="24278" checksum="2C6AC3E10F821C05" modified="2013-07-24" version="1">MKNCISRFCLLALLLLMTIAPVRAEIIGQTTENEYIHRLIADNGQELCFVSGEKDPYLSYADVNFDGINDVVILTQRGASNFVYQFFIFDGEQYVLCPLTFTNYDLDAEHKIVRSSVNGGLAGGIHRETLYRFDGTEAVLLRWAVGEEKEDWTFDADGYTVRHYNDVLTLQVWEHDPEMDGILIFEQDVSTEDENALKEAFQAENDALWSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJU1</accession>
    <name>R7IJU1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prevent-host-death family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000180">
        <property type="protein sequence ID" value="CDE50857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50857">
        <property type="protein sequence ID" value="CDE50857"/>
        <property type="gene ID" value="BN770_00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="87" mass="9816" checksum="1209798311E942FC" modified="2013-07-24" version="1">MAIISPVSDLRNYNTVLEQVSAGSPVYLTVNGRGRFTIRDIADDEEFEKAKAMLRLMCELNTGIRSGEEEGWGSEDDVRAHFHSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK44</accession>
    <name>R7IK44_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51821">
        <property type="protein sequence ID" value="CDE51821"/>
        <property type="gene ID" value="BN770_00631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="32"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="31037" checksum="140685CFAF5BB01C" modified="2013-07-24" version="1">MVFLIILIVLILLYVFLLIPRLPRRDMSALTKVDYAHRGLWNAQRPENSLSAFRSAVDAGYGIELDVHRTKDGVLVVHHDDNLKRVCGVDRRIAQSTLAEVRACHLSGTDEVVPTFDEVLEAVGGRVPLIVELKVEQNVDSLCSAVRERMQHYNGLWCMESFDPRAVQWFRKNAPEIIRGQLAFGLGGEAAHKGVKPLTAFFISTLMQHVLSRPDFLAYEAISEHGLNLPMRLVRLMRPWMVAWTIRSQEALDHTRGKYDIAIFEGFVPPAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKE9</accession>
    <name>R7IKE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51097">
        <property type="protein sequence ID" value="CDE51097"/>
        <property type="gene ID" value="BN770_00026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="44" mass="4832" checksum="412A96349FAD9D6D" modified="2013-07-24" version="1">MIKKYEKLICVVILCITFIIIACIAKSAIIQAAKYLSSMAVSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKF3</accession>
    <name>R7IKF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative fructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51966">
        <property type="protein sequence ID" value="CDE51966"/>
        <property type="gene ID" value="BN770_00722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="3"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="310" mass="32755" checksum="AE4D3E3C23FF38A4" modified="2013-07-24" version="1">MFDITAIGEALIDLTQTGLSASGVAEYAANPGGAPANLAVAAAKLGASAAFIGRVGADAFGTQLRECLRANGVDVSRMLTDAQRPTTLAVVSLDSHGERSFSFYRQHSADLALSPDDVPDETLRRTHFFHFGGVSLTANPARDTVLDAARRARNLGACVTYDPNYRPALWGSRTDAIKQLARPLPLVDILKVSDEEMALLTGTDNLQDGSAALADAGIPLVLVTLGAKGAFYRFRGETGIIDGVPCVVADTNGAGDTFFGAFLSRMRAFTLDSLTIPQLRDMLGYANRAASWTTSRSGAIPAMPTAEEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKI5</accession>
    <name>R7IKI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000193">
        <property type="protein sequence ID" value="CDE51132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51132">
        <property type="protein sequence ID" value="CDE51132"/>
        <property type="gene ID" value="BN770_00293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436723" evidence="2">
        <location>
            <begin position="23"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="229"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="4">
        <location>
            <begin position="530"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="800" mass="85857" checksum="7852AE4DC8170CE1" modified="2013-07-24" version="1">MKRILSLAVAASMLLSAIPAMAETATEATYIPAPYNAEEVDPTKTYLEPVFYQNENGPTIGVTTVGVIQQDGLYFKDSDNDHELDAFEDWRLPAEERAADMVTKMTLTEQAGFVLNALMVMPGSKTLADVKNEDGTINPAKVMTVIPEGETTKSLIMLNSASSSFASMDDQVMSIGKIRAGVYRGGLNYDASVVALYNNVTTAFAEWDSAKAGTPAIPVTLISNPISAGFPDSLGMAAAVLGDGNYDAIKDYAEVDRQMWRSQGIIFMYGPQIDLVTDPRWPRNSGTYGERPDVTAGIITALVDGYQYGKDGVNEKSVVLSAKHFPGDGAAENGFESHTSQGQWRLYPTAGSLEKYQLVGFQAAVDAGVGAIMPCYSRDAADVRSVPQTYRGHEIDVKQLGSAYNSEIITTLLRDIMGFKGFVNSDSGITLTQTYGVESLTSIQRFALLIKAGTDAIGAELAPEYIVSAVEFGLLDKADLDRANINRATALFKQGRFENPYLDYEQADVVRATNMETAHDQAYSLHLKATVLMKNHENTLPLSKDAGTKIYIASYTGTGENEATLKALAELFVQQGFTVCEDMDDADVVYFYVQPKATIKAGASETEGVLSLVDGFEVAQRQLGGGADAAVTAMFGAGGQGKTGEMVDVTTVEGIKKLQKAANKMHEKGGKVIATIVCTSPWILDNLEPYCDALLAQYTTSAASLSNAYSAQVDVIVGNYNPTGKLSVTLPSCEAVIALTEVRDADGNLLYEECASPNDVPGYDKDQYIAPEVLAQSPSGSYIYKDADGNSYVSGFGLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKU1</accession>
    <name>R7IKU1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="8" type="ORF">BN770_00696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51928">
        <property type="protein sequence ID" value="CDE51928"/>
        <property type="gene ID" value="BN770_00696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448390" description="Ribosome-binding ATPase YchF" evidence="5">
        <location>
            <begin position="28"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="365" mass="39870" checksum="CE791387ADBBEFF5" modified="2013-07-24" version="1">MKLGVVGLPNVGKSTLFNAITQAGAQAANYPFCTIEPNTGVVMVPDHRLDVLGEMYHPKKITPTTIEFVDIAGLVKGASHGEGLGNKFLSHIREVDAIVHVVRCFEDENIIHVDGSIDPARDIETINLELIFADMDTVQRRKDKAMKNFRGGDKKAGIEVELADKIYAHLEAGKPARTCPVTDEEKEVLDGWFLLTTKPVIYAANIAEEDLGKPESEIKGLDRVEAIAKSENAEIIVISAAIEEEIAQMSPDEKAEFIEGLGIGQSGLDRLITACYRLLGLISFLTAGEDECRAWTIVNGTKAPQAAGKIHTDFEKGFIRAEIVPFDTLVELGSMAACKEKGLVRSEGKDYVMKDGDIVLFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL09</accession>
    <name>R7IL09_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3343 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000254">
        <property type="protein sequence ID" value="CDE52008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52008">
        <property type="protein sequence ID" value="CDE52008"/>
        <property type="gene ID" value="BN770_00746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE52008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="91" mass="10397" checksum="F110BCEBAD5557D2" modified="2013-07-24" version="1">MREEFCIAAFRSRQQVMAFERDLRQHGVRASVMITPRAVAMGCGLSVRIEREDLRRAVQVYRATNPGNLIGFYDVWQEPTGRTTVRPAGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL62</accession>
    <name>R7IL62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000215">
        <property type="protein sequence ID" value="CDE51352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51352">
        <property type="protein sequence ID" value="CDE51352"/>
        <property type="gene ID" value="BN770_00392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="301" mass="34615" checksum="3D76069D59904EE5" modified="2013-07-24" version="1">MKAYNGITIREILQKRTGWETWSLYEIYAAEFNEAAARFYLDFHCRLTEHPVSLHPVWPLFIEGNYVIKHNQNNMYMLVEGNVSAVKTFPSVALRQLSHNSSQTRLYEVSCAGRQQLISAGRTRALQYTYLWREPLDQMGMVPEVSVTDLTGGAVASGEANILPHNKTLRIKSSFDGELIISNKSHVVDKRKITADKYMELDGLAFGISIQIMIGFDVIWQINFKKQRLIRINEDVEMLKHITNVSGVAIPAPHSLRNILAGMRSYPTICRWIRMCIKNNAIDEQAYRRLQETYRRMNMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILM9</accession>
    <name>R7ILM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000226">
        <property type="protein sequence ID" value="CDE51532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51532">
        <property type="protein sequence ID" value="CDE51532"/>
        <property type="gene ID" value="BN770_00481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436029" evidence="2">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="112" mass="11471" checksum="C3CD0C646C6B0E8E" modified="2013-07-24" version="1">MKHVGRAVFFACLTALLLLGMRQLVVAPESASAESSPAPPGIPAVMTAALPAPESAAASASTAQEALHRPAALPAHPPMPVLTRADGCGWLITGRSYVRTVYIAFHLEGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMD8</accession>
    <name>R7IMD8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="7" type="ORF">BN770_00602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000243">
        <property type="protein sequence ID" value="CDE51762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51762">
        <property type="protein sequence ID" value="CDE51762"/>
        <property type="gene ID" value="BN770_00602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9760" checksum="1075EE2C12CD9AD9" modified="2013-07-24" version="1">MTKSEIIATYAQHEGDTGSPEVQIALLTDRINHLNEHLKTNRNDHHSNRGLLLMVGRRRGLLEYLKKTDIERYRALIAKLNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMH4</accession>
    <name>R7IMH4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermidine/putrescine ABC transporter permease protein PotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51812">
        <property type="protein sequence ID" value="CDE51812"/>
        <property type="gene ID" value="BN770_00624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="113"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="330" mass="36601" checksum="7DA7BC5C4EBF4537" modified="2013-07-24" version="1">MLSNLSLPWWAYALMGAGLCVFIALIALTIHRNRGMHRSLFASPYALWMMIFTIVPVILIAYYAFTDSSGAFTLDNFRSFWDSNYESNKIILDAMGEAGQAYISRGTVNVDTLVYSLWMAFQCTVICLLLGYPAALIMADREIKLGPTLVVLFIIPMWMNFLLRTIAWMSLLEDNGLINTVLRALGFNGVQLMYNSGAVLLGMVYNFLPFMVFPIYTLLSKMDYRLTEAAADLGCNNWQTLWKVTMPLSIPGIVSGITMVFMPSVTTFFIPRVLGGGNTMMFGDLIEAKFLTEGNWNVGSALSLIMMVLILISLSILRKADPNGEGGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMI8</accession>
    <name>R7IMI8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MiaB-like tRNA modifying enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00637</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51827">
        <property type="protein sequence ID" value="CDE51827"/>
        <property type="gene ID" value="BN770_00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034557">
        <property type="entry name" value="ThrcA_tRNA_MEthiotransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00295">
        <property type="entry name" value="threonylcarbamoyladenosine_tRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="138"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="432" mass="48505" checksum="B819DEA81B3E9A83" modified="2013-07-24" version="1">MKTAAFHTLGCKVNQYDTQAMLEKFRAAGYEIVPFDADADVYVINTCTVTGTGDKKSLQLARRLRREHPDSALILAGCLAQRKPEELLETGARLVIGTQHRGEVVELLEKALRENTSINAVNELNATTPFEPLTITSQEEHTRATLKIQEGCNNHCTYCIIPSVRGPIRSRPVDEIRAEAERLAQAGFTELVLTGIHLTSYGRDFTPRQTLLDAIRAVQDVPGVRRIRLGSLEPTVATVEFAQALRTMDKVCPQFHLALQSGSDTVLQRMARRYNMRMYRQAMENLRAVYPMAAFTTDVLTGFPGETEAEFEETRDFIREARYAKIHVFPYSQREGTKAAVMPGQLSNAEKERRARLLIAVGDEMARLYREQWVNEVAEVLLEEPVHGHWTGYTPEYIAVTLPEGYAGRQGEFVRVRLTGLNESGMDGTPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMP8</accession>
    <name>R7IMP8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51902">
        <property type="protein sequence ID" value="CDE51902"/>
        <property type="gene ID" value="BN770_00685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046169">
        <property type="entry name" value="DUF6171"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19668">
        <property type="entry name" value="DUF6171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="91" mass="9992" checksum="0FC6F0503D939040" modified="2013-07-24" version="1">MADARKPCRCTLLESGQADMAKLVRDYVDSLSTDEKTDEATYAARLNICRTCDNLHSGTCALCGCYVEARAAKKRQGCPKVPEMWGAEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMZ7</accession>
    <name>R7IMZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-alpha-glucanotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000254">
        <property type="protein sequence ID" value="CDE52007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52007">
        <property type="protein sequence ID" value="CDE52007"/>
        <property type="gene ID" value="BN770_00745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="131"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE52007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="590" mass="67758" checksum="E11D304FE0392402" modified="2013-07-24" version="1">MLLHDSHNEFYRTPSGPAPAGSNVLIRLHCDEATSVVLRTWMTEELCYTMLPTAEHVWEVAIPLPTTPGLFWYYFLIYRKDGRTIRYGNQPDKLGGVGVAYDHGEPESFQITLYDPAYKTPEAFHGANIYQIFPDRFRHAPTKAVDDRKDRYVHKNWDEELLGVGDLRGGKYQELDFYGGTLTGIQEKLPYLKDMGIDIIYLNPIFRARSNHRYDTGDYTQVDPLCSTNTEFTELCEAAKKVGIRVMLDGVFSHTGEDSVYFNHFGHYPTLGAYQGQSSPYYDWYTFNHYPEDYKAWWGILSLPELRKDNPEYQKFMFQPHEGVVPRWIEAGSCGWRLDVADELPVDFLRKLRAAAKAADPEAVVLGEVWEDASNKVAYGETRCYCTGDTLDSVMNYPVREAILNFVMGKTSASTFVRLIHHQEEVYPAQFRYALMNLVGSHDRCRALNILAGRECQELSKADQQHVHLNVEEYELAVRRYKLCIDLLCALPGCATVYYGDEVGLTGCHDPWNRRAFPWGREDKSLQKYVANKLRHRQESDLLRLGYCDIEAPDDDTLLITRRMKDGHDALGQESTVTGREIIKVCRKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I435</accession>
    <name>R7I435_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsF</name>
        <name evidence="9" type="ORF">BN770_00972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46654">
        <property type="protein sequence ID" value="CDE46654"/>
        <property type="gene ID" value="BN770_00972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020815">
        <property type="entry name" value="Ribosomal_S6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01048">
        <property type="entry name" value="RIBOSOMAL_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="132" mass="14801" checksum="A1BD5786E5CE531A" modified="2013-07-24" version="1">MNRYELTYIIDTALEETARKELIEKVSALIAANGGEVEKVDEEPWGKGAKRLAYPINYKTEGWYVLVTFKAPADLPRELERNLEIYDDVLRYLVVKLEVKRSNVKPRAPKAAPAVEAPVEAAETVEAPADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I452</accession>
    <name>R7I452_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46231">
        <property type="protein sequence ID" value="CDE46231"/>
        <property type="gene ID" value="BN770_00791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="90" mass="10048" checksum="B486268D04A179F3" modified="2013-07-24" version="1">MTHVLTIDGRQFSDGKAVHRMLKKLLCLPDYYGGNADALYDALDERGERIDLRLLSLGGEDTAKTLRKVACVVQDLGGTVIWADEKQERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I492</accession>
    <name>R7I492_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46465">
        <property type="protein sequence ID" value="CDE46465"/>
        <property type="gene ID" value="BN770_00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447961" evidence="1">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="397" mass="43883" checksum="F2A7E2F0FD8AB48C" modified="2013-07-24" version="1">MMKRMFCLLLTVLMGVSCIFASAEDAQDNSADALTLAELQAFAARMQTLAMASTPLNDPADAKTEDGYAFEYSFGTIYADSPAMSIDTQLLSIVLTSAEERGPRDIQVGDELSIVLEANYSENPSLRGSRESAVLYVLDLLPESMRWGEVKRDGQRVQTVEYAVHERVETDGEGYTDTGVIFTMEDNIVSAIRVYGLSARTTEAEISTVRDNLRFDALFDDYVQVPSSYNGADLPMFDGTDLQFSGIDFMSLTPESAADVLGDVIDDVWVENGTDGYVRTMTFAACDITFLYDAQKQNPQVEMLLIAADGMEGPRASRIGDTFAQVYNRFRNDNTAIDENDTEHLYGDEESGQYGVVEYTVDGTVMRFGLVLDDGVRVVLRLEFTASVLSEIMVYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4F3</accession>
    <name>R7I4F3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46351">
        <property type="protein sequence ID" value="CDE46351"/>
        <property type="gene ID" value="BN770_00833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="98" mass="10716" checksum="66D3B2AD457DC7E1" modified="2013-07-24" version="1">MENIGEKIMQARKTKGMTQDTLAQLVNVSRQTVSHWENGRAMPDVATAAQLSKVLDVNFLADEAAEDAAVQPPEAVPTVQEPVQETQEQTDGRFVNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4K2</accession>
    <name>R7I4K2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46575">
        <property type="protein sequence ID" value="CDE46575"/>
        <property type="gene ID" value="BN770_00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1027" mass="110749" checksum="8E5650E222B7A92F" modified="2013-07-24" version="1">MDQNNYQDRSVQQPAAEEKTTPRRRRADMYQQQGNAANVTNAETAKPAVEDVPGTTQKMPPIRSTFQRNAEAGETKQVKPVAPVAPVAPVAPVAPVAPVAPAAEKPNAPFGQNRSANIPTPGVPRPDASRTSLPPMRQPQNVIRRPVKLDGMGEVKSAAERQEEARQRTNLNMEHAGASSRRNHLQNEFARPQEDVEEEAPRGKKSALAVVIAIVLVIGLLVVGLLLIPDSNTGFLGNLKRTITAPLTGRTQTQAVAPTASSFTASITSSTAPYQITFNLVTSNNVTDVRVVDENGNPFDTVTLMSQSNTDNTVVWIFTLTTADAYSGVIEAEMLSNEAWIPTGFRQTVSLGGNSPASISNLPTNFSTAANNPAQPDAHELTADSTTEPTVSPAMAENTQNLALTISTEAPTEAPTLMPTTVPTEIPTEMPTEAPTQAPVLVTLAPTEVPTVTPTMAPAPQKTEEIILPEEETTETPEPDPTEVPTEEPTPEPTATPRPVLTFSADASADPSLIADTVVYRDDSRTAVKEYTRDEKEIIDMPADDDYTTRKIGVLTYRGTAFRQNAAVGTVEDATQLTQVWAVETGSLKGKSRTYYGFSWANQPVIEQWARRVRQDMPLLDGKNDKTALKEVIAASLDGKIYFLDLEDGSKTREPIELGYPMRSTPSLSTLAYPQMSVGQYARFLANKTGSIGQHFYDLLTNKENLTIDGLDGGSKKDRAYNDVGAFDGSALYDRNSDTYITAGTNGMLYTVHMNTVYETPTDESGNLKVSPTITMMKSRTKKQKDAYTAVEAPIAMYGSYVFYADVEGVLRCVDTTTMTTVWAVETGDAVKSAVALDFDDDGRLWLYTANTLLNRSKGDVAIRRYDATTGAEDWSLALNATKKKDYTAGAMASPVIGQYQLGDLVYYTLSYISASGSEKLLGSGAKAQEGVLVALNKQTGKVVWAKSLGGYCYSSPVAVYNENGKGWIIQATSDGVLMLLDGLTGETINTLQLNGTIEASPAVYQNMLVIGTTGKGTSFLYGVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4S7</accession>
    <name>R7I4S7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glucosidases family 31 of glycosyl hydrolases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46496">
        <property type="protein sequence ID" value="CDE46496"/>
        <property type="gene ID" value="BN770_00905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="691" mass="79244" checksum="14EC420948D3993C" modified="2013-07-24" version="1">MRVEQQNHRLIIHDGRSECWIDPWGKDSLRVRMSAEPGMDDHDWALTEPVEATDVVIRSEVIDTTDPWYKGEEWAKYHQTGTKWTLTNGKITAKISTEGWITFLNQRGEVLTAEYWRNRDRINRYCVPLRVPARELKPIPGGTDFSLTARFEAYDDEMIFGMGQYQDRHLNKKGSVLELAHRNSQSSVPFFVSSRGYGFLWNNPAIGTAAFGTNVTEWSAKSTKKLDYFITAGDTPADIEANYTAATGRTPMMPEYGMGYWQCKLRYRTQEELLSVAREMKRRGLPLDAIVVDFFHWTRQGDFRFEPRDWPNPQAMVDELKAMGVETVVSVWPTIDEKSVNFGEMAERGLLVTADRGNAIVMTWMGNTFFFDATNPEAQAFVWEQCKKNYYQYGIRCFWLDESEPEYGPYDFDNYRYYAGPALQCTNTYPVGYAKCFYDGLREAGETEILSLVRCAWAGSQKYAVLTWSGDISSTFRAMREQLQAGLSMGMAGIPWWTSDIGGFLGGQVDDPAFRELLVRWFQWACFCPVFRMHGERSPWYEREQEYIGDVRQLTSGQSNEVWSFGDEVYEILRKYLFVRERMRPYIREVMRAAHEHGDPVMRPLFYGFPADKAAWSVEDEYLFGADVLVAPVLEAGARMRDVYLPAGADWVDAATGAEYAGGQTVRMDAPLDTIPVLIRKGSGVRVYSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4T8</accession>
    <name>R7I4T8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46660">
        <property type="protein sequence ID" value="CDE46660"/>
        <property type="gene ID" value="BN770_00975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="293" mass="31768" checksum="B5B3D06C0ACCF63C" modified="2013-07-24" version="1">MELLSASRGFLKCNFHCHTTCSDGRLSPKDVMAAYRALDYDVLSITDHREVTRPAADEIPAGLMLIPGTELDFLLPTQAVHLLGLGVSPDIADCWNPNGTPQQAIDSIRACGGRAVLAHPAWSLNTTELMCSFRGLSGVEIFNSVSSVPTNALRGDSAAMLDPVFANGQLLNCFANDDSHRYEGECGMSATMLNTNDRSVAGILRAIDEGRFYATQGPEIRELSLTDGVLHIACSPAKYIIFYSNEVWIPNRTRALEGQTSADYVVSPRESFVRVQVVAEDGKSAWTSPIKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Y7</accession>
    <name>R7I4Y7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">BN770_01000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46700">
        <property type="protein sequence ID" value="CDE46700"/>
        <property type="gene ID" value="BN770_01000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="236" mass="25387" checksum="3513AE100CE2C4DD" modified="2013-07-24" version="1">MAVYKRVLLKLSGEALKTGSDLFDFDQVHRAAAVIRKMADMGTQIGIVIGAGNIWRGRQGPAANMDAVTADQMGMLGTVINCLCMADALRQAGVDAVVMSAVDMNRFCEPFNAMTARRYLSEGRVVLFAAGSGNPFFSTDTAVALRAIEMQVDAILMAKNIDGVYTADPHKDPNATLIKDITYQEALRKGLKVMDAAAFALCAENHVPMVRVFGLDVPENLISVLEGSDMGTFVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I561</accession>
    <name>R7I561_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47024">
        <property type="protein sequence ID" value="CDE47024"/>
        <property type="gene ID" value="BN770_01118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="14"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="574" mass="63719" checksum="32DD6D77D25A771B" modified="2013-07-24" version="1">MILSMRMRNIALIEELSLEFGEGLHVMTGETGAGKSIVVDAVNLVLGGRAARELIRTGTDKAWVEAVFDASGNEEVAKWAQAQELDDFDGTVTLYREITRSGRNLCRVCGVVMPLSALKDIAVLLMDVHGQHEAQFLMNSQYHLLFLDAAGGDDYQALLSRVDAAYQAFITNHRQYARLVKENEKKQYRMESLKKSLEELEKARLKLGEEETLAAEKERFRHSEKIATAVAAAHRAISANDDSETVLSRVKEAADALRSLAAFGESYVSLAQRCDSAYYELEEIGYELADLTEKGEFDPVRAEKVETRLDLIRRMERKYGETVAEVLSQQQKMQEEYDNYVSLDEQVAKTGAEHKRLLAQYRQLARQLTEARHGLANEFEKNMMAQLKDLGMGNTIFQVSFAIRPEGKIFMPQSVGDDVIEFMISPNPGEPLKPLSKIASGGELSRLMLAIKSLEAEKGGVGTMVFDEIDTGISGRMAQVVAEKMALIARKRQVICVTHLPQIAAMAAHQFLVEKRVEGERTNTSVRLLSPKERISEVARMLGGADGSEGSAMSHAAHMLYVAGNLPEEDISHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5K8</accession>
    <name>R7I5K8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000037">
        <property type="protein sequence ID" value="CDE47159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47159">
        <property type="protein sequence ID" value="CDE47159"/>
        <property type="gene ID" value="BN770_01156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="43" mass="4698" checksum="D825AE8462A28440" modified="2013-07-24" version="1">MPTKHFLPLLLLPFVLLTVFLCLAVLLGGQDFVHALLNVAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>R7I691</accession>
    <name>R7I691_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="13">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">metG</name>
        <name evidence="18" type="ORF">BN770_01107</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="13"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47011">
        <property type="protein sequence ID" value="CDE47011"/>
        <property type="gene ID" value="BN770_01107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 13 14" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="17">
        <location>
            <begin position="562"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="522"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="13">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="13">
        <location>
            <begin position="301"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDE47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="664" mass="75439" checksum="BA58D770461C36AF" modified="2013-07-24" version="1">MCESCKKPFYITTPIYYPSSNLHIGHAYCSTAADSMARFKKLTGYDVYFLTGTDEHGQKIERKAKEQGVTPKEYVDKIVAGIKDLWKLMDIDYSDFIRTTDDRHVKCVQKIFKQLYDQGDIYKSEYEGWYCTPCESFWTELQLKDGCCPDCGRPVEKTREESYFFRLQKYAEWLIQYIEEHPDFIQPASRANEMLNNFLRPGLEDLCVSRTSIKWGIPVTFDEKHTVYVWIDALSNYISALGYGTDNDALFQKYWPADVHLVGKEIVRFHTIIWPIMLHALGLPLPKQVFGHGWLVINGKKMGKSVGNVVDPVVLCNRYSSDAVRYFLMREMPFGSDGEFTLKAMLTRINSDLANDLGNLVSRTVAMIEKYFGGTVPAIDAVDEAVDKPIWDEAEQLSGKVENYVNAFQFSNALVETWKLISDCNKYIDMTQPWVLGRSEEGQPRLKTVLYTLAECVRRVAVMIGFVMPRTPERIFEQLGVTDDALKTWDSVCKPFAVLPEGLTVHKGAALFPRLDIQKEIERDAPAEEPKKEEKKPAAKPEKKAEKKHETPDFPAEIAFDDFCKCKMQVARVLSCEKVEKSNKLLQFRLSFGKDGERTILSGIAKYYKPEDLVGKQVVAVVNLAPRKIAGIESQGMILSAVDDEDNLRLMSVGEGVEDGAIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6M8</accession>
    <name>R7I6M8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="7" type="ORF">BN770_00081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47141">
        <property type="protein sequence ID" value="CDE47141"/>
        <property type="gene ID" value="BN770_00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="117" mass="13243" checksum="4BD0DBD82A167C84" modified="2013-07-24" version="1">MERRYRLQKNKAFQYVYHRGRSAACRDLVMLVAKGRGMKVGFSVSKKVGNAVTRNKVRRRLRECFRPYLGDVKSGLYVVVARPSAATASFSSLQKDVRYLLKKHGALPTQPKSPDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6S5</accession>
    <name>R7I6S5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47569">
        <property type="protein sequence ID" value="CDE47569"/>
        <property type="gene ID" value="BN770_01286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="165" mass="18067" checksum="D41F41B2C67B2F80" modified="2013-07-24" version="1">MRDDNVGAVHLTVLSAMPGRLRLQLEKPIEGEAIFLSIPGMQSCRYNPRIQTMLCCYDKAVISESDLLVRIGALYARLQQTAVLHVKHSEEEGFSMAPSGYLALGCIVLDGMMTLAGSTLTRYTRWLSAGATLTDVVGPAYPDLHTTWLSTPIRNCTHAAVSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I759</accession>
    <name>R7I759_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000042">
        <property type="protein sequence ID" value="CDE47301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47301">
        <property type="protein sequence ID" value="CDE47301"/>
        <property type="gene ID" value="BN770_01202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435546" evidence="1">
        <location>
            <begin position="22"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="225"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="450" mass="49367" checksum="0B4034CA00AB5942" modified="2013-07-24" version="1">MKKWFCALGMMLALLMSVALADGVKVTFAEKNGQINGGYDYTLKLNVSPASDKDLTVSLTCDGLDGAYSVVIPAGQKSTMLTVPTQVVEERGKVVFELQSGDGYTGAGKHTLTIQRLPNVQFYLGINFGTVGKKMSVRMTVTNSSTIVKGNNTFQLRDDKGTVLAEAKWSNPSGDMSFSITPTADMEGYTRLSVWLGDRCVADGGYLTVVAKGQRAVKNVETERKLVGIGMDCGFGGKNTDQVLEVLAKHNTNITFFMTGYFVRTFPEESKRVLAAGNEIGDHTNTHPQLTKERPYSMMRQIVFPAETMAETLGVSPRLMRPPYGDVNSNVISVSRAEGMECVLWNMSTKDSIGKYTVEECIKNGTTRAKLAPGNILLCHLDANHSWEILDAVLTYYEEQGYTVLPISALIYATGGSLPPMPSTREALLYTDDYWPNWLAERGIEIETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7B0</accession>
    <name>R7I7B0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="2">PPIase</shortName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000037">
        <property type="protein sequence ID" value="CDE47168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47168">
        <property type="protein sequence ID" value="CDE47168"/>
        <property type="gene ID" value="BN770_01164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006529936" description="Peptidyl-prolyl cis-trans isomerase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="205" mass="21859" checksum="7098A917817E8CDA" modified="2013-07-24" version="1">MKRILPLLLILLLILTGCSAQNADSPAADAPTDTPMTGISYVQIDVKDYGTIVAELYADTAPITVANFLSLVDSGFYDGLTFHRIISGFMIQGGDPNGNGTGGSSQRIKGEFSANGVQNDLKHTRGVLSMARSSAMDSASSQFFIMHADAPHLDGQYAAFGKVISGMEVVDAICEHTPVTDRNGTVAKANQPVIERIIRVEKPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7J3</accession>
    <name>R7I7J3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic beta-glucosidase/beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47466">
        <property type="protein sequence ID" value="CDE47466"/>
        <property type="gene ID" value="BN770_01267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435563" evidence="2">
        <location>
            <begin position="25"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="185"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="832" mass="91314" checksum="48ED1D8D7263756A" modified="2013-07-24" version="1">MKKFSRALSFVMTLAMMLSGIAVAEQQYFNNGGGGEFVDPHTFTKPYAVNEVIVPADEATGQVALEAHVKNIIEVDGLKFKDLNGNGTLDVYEDWRQPVDARVDDLLSQMTLDEEIGLLWHASTGGTFTSMYPYTEEWLYSNEPTYTAADGSCYVPMYHSIISDNVTTYLHNVNGTPETLIYENNAFQEIAETARLGIPVVLSCDRSYNTWAGMVNMPNYAVGIAHDPELLYNLVAQYAKEERAIGFHVPFHSYGVEIGSWYGDDVNYIAKMVGIETKAYEENGVNACTKHFVARGGRSNYFNAKSPANLVDSWLVGWKSAVIDNGSGWIMLNNGKFLNDCNVCYDSESMAVLRQQLGYDGCVVTDWPMWMQVPSASGTTPEGLDLSTASVGELYATIFNADVDQVGCFFMVEDDVPVDYDAVIARYPGMMQPMWPNAVKEQLELGNLTQETIDKHAKRVLRNKFELGLFEDPYGNLEDALELCASDEYKAQAFDMTTIEDVYRARTAEMNAMEIQLQTEATVLLKNDNILPLKAEQKVYVAGTSKDTVAMDKEAIAAYATVVDNMEDADVIIAHVTAMDDATELLFEDAADAEKPVVLCYDGGVSNEPDAYAVNSSAAVLFLTYDCTPDHGSSMGNFYHKTLPSVLADMLYGVKAPSGKTVFEMAWTSEDAELDWGELQFDTGVDTKTRLYMAAVVRNNPTADLPTNLGDVMYPAHFGMRYDQPADITCNTLIAPQGVREVSEETSSGTRMATKVLNLAKAGETFEINFIAENNGADGYINVEVLVDGELAATKMIAVSAGSFHVVTIPLTLDAGEHVITVGGMTANLTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7M5</accession>
    <name>R7I7M5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47258">
        <property type="protein sequence ID" value="CDE47258"/>
        <property type="gene ID" value="BN770_01186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="294" mass="31371" checksum="7EB3CDC80559AE40" modified="2013-07-24" version="1">MKTYAEYRKQVEEALSGQLRSLGEIPDILLKAMEYSLLAGGKRLRAVLLLAACESIGGDTGKALPFACALEMIHTYSLIHDDLPAMDNDDLRRGQLTNHRKFGEDVAILAGDGLLSAAMELMARQAAKLAKAGDCSGVLAMEAIARHAGVTGMVAGQTMDVTSEGTKPTADKVRYIHLHKTADLLTAPVEAGLLLAGATQDQVKYGCEYGQHLGMAFQMVDDLLDVIGTEEALGKSVGKDVAEEKLTWIAIRGIEGTREDAARETALAVDAAAKIGGDMKFLQTLAQSTLNRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7V6</accession>
    <name>R7I7V6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">BN770_01444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47944">
        <property type="protein sequence ID" value="CDE47944"/>
        <property type="gene ID" value="BN770_01444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="197" mass="22173" checksum="36D9ECF0C2A86A64" modified="2013-07-24" version="1">MNLIPYVVEQTNRGERSYDIYSRLLKDRIIFLGGEINDDVANTVVAQMLFLEMEDPDADICLYINSPGGSVTAGMAIYDTMQYIKPQVRTVCIGMAASMGAFLLMAGQKGKRCALPNSEVMIHQPLGGAQGQATDVQIQAEWLLKTKEKMIRMKADMTGQDIERIRRDVERDHFMSAQEALEYGIIDEIFDPRKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I819</accession>
    <name>R7I819_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein translocase subunit yajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48019">
        <property type="protein sequence ID" value="CDE48019"/>
        <property type="gene ID" value="BN770_01495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="135" mass="14600" checksum="17EBCB4E412705E4" modified="2013-07-24" version="1">MEFLTKLLGIATAVAETTTTTGAADPAAVTTDSAAGGIVGILFSLLPLLLVFVLMYFMMIRPEKKRRKKEQDMLASLKKGDRVCTIGGIYATIESIKDDTITLSVGKGDQTMVVARWAIRSVEDVTIENETESLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8G5</accession>
    <name>R7I8G5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47583">
        <property type="protein sequence ID" value="CDE47583"/>
        <property type="gene ID" value="BN770_01296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="25576" checksum="110D5110416F7440" modified="2013-07-24" version="1">MSLLEVNDINVYYGAIHAIKGISFSVDEGEVVTLIGANGAGKSTTLNTVAGLLRPREGSIHFGGKDLARVHASDMVKHGMALCPEGRRIFQQMTVLENLEMGGFTRPDKEIPGSIEQMFELFPRLKERQKQIAGTLSGGEQQMLAMARALMSKPRLLMLDEPSMGLAPILVEQIFDIIRALHKSGTTILLVEQNAQMALSVANRAYVLETGKISMSGDAQELLHNDAVRKAYLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8H3</accession>
    <name>R7I8H3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase pepF/M3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47910">
        <property type="protein sequence ID" value="CDE47910"/>
        <property type="gene ID" value="BN770_01424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09607">
        <property type="entry name" value="M3B_PepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034006">
        <property type="entry name" value="M3B_PepF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="187"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="582" mass="65304" checksum="247938CA3F2D8133" modified="2013-07-24" version="1">MNPNWDLSYLYKGFDDPAFLADLKRFPEEIKVEQAILDGGDDPQTKLEKLTDQQEVLGALSDRLASFCSLTQAVDANNADATKYLNVLDVIFNDSRIVSSAVTRYIGSLANLEDLIAASPKLQKVAFYLRESAENAHHTIPEAVEPWILEMSLSGGSAFSQLRDKLDSTHTANYRGQEIPLSAVRGLAYDADASVRKDAYEAEIASYKKMELPMSYCLNAVKMEARTLSKAKGYPSVLDMTLSDSRMDRATLDAMLTAIREYLPHFRRYMKAKAKLLGHQNGLPFYDLFAPVGQNVHTYTVEEAREMLVRLMGQFTPEMGKFIDNAFEQRWIDIYPREGKTGGAFCSPVHFADRSLVMTNFTGSFSDVSTIAHELGHAWHNRCLAGLPYSMIDTPMPLAETASIFNEQLLAHMVLKDASPDEQLSLLEGNLMETNQTIVDIYSRYLFETEVIDTRADHAMNVDELKDAMLRAQEASYGDGLDPEIRHPYMWACKSHYYSSGYNFYNFPYAFGELFAKGVFAQYLQKGAAFVPDYCRLLRSCGSGTIADVAASVGIDVRNPDFWRSSLEVVKGNIDKFCELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8V6</accession>
    <name>R7I8V6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4367 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000074">
        <property type="protein sequence ID" value="CDE47931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47931">
        <property type="protein sequence ID" value="CDE47931"/>
        <property type="gene ID" value="BN770_01439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025377">
        <property type="entry name" value="DUF4367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14285">
        <property type="entry name" value="DUF4367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4367" evidence="2">
        <location>
            <begin position="238"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="290" mass="32757" checksum="B11554DC19F0FA3A" modified="2013-07-24" version="1">MSGTKKEHIKIILQTIENGTLSEAETEQRLLGLVRQEAERKDRPADLELIRACLELGDPLQGRSGDVDSERIDKLKQRIAIACEERRRKKEKRKAILKFASFGAAAVLLVASFFVPQHWSWIESWSTPDEQQRVLIGHEVTVDRVGKALADHAAVEQQTYAVNSSAEIDDLLGFHSGVPQTLDDEWTLSRGYVDYMSGYIKLSLMYVSSTDPQKRISANMNLFTDIEHAAFTFEQTNDGQMQRVNGLDIYVADNEGQTTAYWYNKNMYICLSGNASETEIINAILYMIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Y2</accession>
    <name>R7I8Y2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47956">
        <property type="protein sequence ID" value="CDE47956"/>
        <property type="gene ID" value="BN770_01456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="207" mass="23355" checksum="D08A91DF0AE50D0B" modified="2013-07-24" version="1">MMNDRARLWSKRKSAPFADPRDEERALREMRKSIDHSFNFNIDFKGEQPYMDNYRATVSFGAGCWQNTGTRRRADVPQQQERQHSILVSRQGLHSGLAMLVVAVCLFVMGVFWLNLQSQIQNVSTQIGVRTTNINAKQQENDTLQAQISVATKEQSLLQRAQKLGMKEGKNVQVVELSGVPDAICGLQEGAQNTMTTTDVALLMHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I930</accession>
    <name>R7I930_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion-translocating oxidoreductase complex subunit E</fullName>
            <ecNumber evidence="7">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rnf electron transport complex subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rnfE</name>
        <name evidence="8" type="ORF">BN770_01121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47027">
        <property type="protein sequence ID" value="CDE47027"/>
        <property type="gene ID" value="BN770_01121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00478">
        <property type="entry name" value="RsxE_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010968">
        <property type="entry name" value="RnfE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01948">
        <property type="entry name" value="rnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="208" mass="22191" checksum="11038FC3E5465988" modified="2013-07-24" version="1">MANQKKTFMSVLLNGLIWENPTFVLMLGMCPTLAITTSGMNGIGMGLAVTAVLIFSNLFISLLRNIIQDSVRIPAYIIIIASFVTMIDMLLKAFLPDLSQALGMFIPLIVVNCIIFARAESFASKNPPVLSIADGLGMGLGFTFAITLLSVIRELLGNGTFFGLQVMPASYQPMGIMTQVPGGFITLGLLLILVNALSNKSKKKGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I931</accession>
    <name>R7I931_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48011">
        <property type="protein sequence ID" value="CDE48011"/>
        <property type="gene ID" value="BN770_01490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447703" evidence="1">
        <location>
            <begin position="25"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="71"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="823" mass="91055" checksum="1474E341363EFCE6" modified="2013-07-24" version="1">MKKWIALCLSLVMVLSYCGMAASAEERYLGVMLSTNIMSLDTNLATDGESFEVIADCVDGLMQMDADGAAIPALAESYDLSEDGKTYTFHLRDAKWSNGTPVTAADFVFAWRRICKEAGEYAYMFDTSVGCVKGADAIIYDGADPATLGVSAPDDKTLVVELEVPVSFFPSLMYFPTFYPINEAFYTSLEDGTYGTSPETFLSNGAFVLESYTPGTANLTLKKNPDYWDANRVQLPGIKYQVVGSSDNALTGFKTGALDVVTISGNQVASASKDASLAKSLTVTGAGYLWYLSFSQTENNAQGGMLANVNLRLAISNSIDREALVEDYVMDGSLATYTAVPPQFAASATTGADFAADQDAFADVCGYNPEKAVEYFNAAVEELGTDTFTFTMIYGNNEGDSVSKVAQAIKSEVEENLPGVTINLQPMTKAERLDKMQNDNYDIALTRWGPDYADPLTYLGMWITNNSNNYGFWSNTEYDQLITDCTTGAYISDYDARWEALFKAETLVMQEAVIAPLFTKANANLITDPEGKRRKQMAQVNLEIVLLRRFSHGFRRDVAPEVLHGNLAQLALFTQLSNRLIDGFQQACTVVRLAGRNRHKVCFLRQGDNLDVRVRTLLHIVRNGHFAVQRRVRAARQHLHNRLVKRIHANHLCAELFRQNHVGAGDGVCGLFALQILKGLDVLVVAPDDQRRAVEGIGGAEIVLFRALFGHINAVGGNVVAAGVNAGEDAVPLHGHERRLHAQLLRNRRRNFHIKADQIAVFIRVRPRRPSTLRRNDDFALFLNARQLILAFLRQSGHAQRHHQRQQETDKLLHFECPFHLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I942</accession>
    <name>R7I942_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fructose-1 6-bisphosphate aldolase class II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48125">
        <property type="protein sequence ID" value="CDE48125"/>
        <property type="gene ID" value="BN770_01545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="33880" checksum="0B11A802CDEDDBBE" modified="2013-07-24" version="1">MALVTTKEMFKKAYDGGYAVGAFNVNNMEIIQGITEAAGELKAPVILQVSKGARAYANHTYLVKLVEAAVIENPDIPIALHLDHGDSFELCKSCIDGGFTSVMIDASSKSFEDNIALTRKVVEYAHDHGVVVEAELGTLAGVEDDVKVEHGQEMYTHPEEVEEFVTRTGCDSLAIAIGTSHGAYKFKPGQKPQLHFEVLEECSKRLPGFPIVLHGASSVPQEFVKEINQFGGNMPDAIGIPEEQLAKAAKMAVCKINIDSDIRLAMTASIRKYFAEHPDHFDPRQYLKPARAAVKAMVAHKIVDVLGCAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I969</accession>
    <name>R7I969_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000081">
        <property type="protein sequence ID" value="CDE48150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48150">
        <property type="protein sequence ID" value="CDE48150"/>
        <property type="gene ID" value="BN770_01562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="370" mass="38495" checksum="97A4298EEE8C2A43" modified="2013-07-24" version="1">MKKIFIIGGGIAALEAAKSARSTQRDALIVLISAENFLPYSRPMLTKQLMGKVTAQDLAVESAAWYDEKDIVVLTGRTVTAIDPVGKTLVAGGTPFHWDSLILATGASCFVPPIPGADGANVVSVRTFDDVARVREIAKAAKNAAVIGGGVLGLEAASSLAEAGLSVTVLEHGDQLMKRQIDAQAAQHLESAMAGKGVKLLKNADSARIDASGVTLVDGTRVPAELVIVSAGVRANIRLAKDAGIAAERHITVDDHMRTNLPDVYAAGDCASMGVSYALWTEAADMGRIAGINAAGGDAAYQALPRPLIFHGFGTALFAFGDAGRQANIAYEIGEMPGARYYSAGGKLVGAVLTGDIRRMEEVTNLILQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I984</accession>
    <name>R7I984_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48056">
        <property type="protein sequence ID" value="CDE48056"/>
        <property type="gene ID" value="BN770_01515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="13"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="347"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="600" mass="66432" checksum="6487F68E20D21A03" modified="2013-07-24" version="1">MLSLIGQNWTHFLWALIATIMMVIIGFLTPLLLSEIVDSILGSEPFTMPDFLMNPINDLGGRDFLRQNLWIPALALILMNIVNGVFTFIKGRSSAIASENIARKLRNDLYRHLQHLPFAYHVKAQAGELIQRCTSDVDTIRRFLAVQVMEVVNTVLMVVIAMSILLPRSVPITLYSLILVPPLFCFATWFFKMVHKSFEVADEADGVLNAVLQENLSGVRVVRAFGQQEREVEKFDRVNNDLRKKNLRLNELLAIYWGGGDAISMTQTLLTLVVCIIYACNGWITVGTLIVFTSTLGMLLFPIRQLGRTLSDAGKAMVSMKRVQAILHEEAEPDEPNAMKPDLHGDIVFDHVSFAYPDDNVPVLRDVSFTIPAGKTAAVLGGTGSGKSTMMYLLQRLYTPTSGKITIGGVDIQQIDRKYLRAHVGLILQEPFLYSKSIRENVGITAPEQEAERIEHAADIASASGFIAKADKGWETVVGERGVTLSGGQKQRIAIARTLLKDNNILIFDDSLSAVDTETDAQIRAALRHEQKDVTTLIISHRVTTLSQADLILVLENGQITQQGTHAELCSQPGLYQRINSIQNALEEELTQAKAAEGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I994</accession>
    <name>R7I994_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000083">
        <property type="protein sequence ID" value="CDE48170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48170">
        <property type="protein sequence ID" value="CDE48170"/>
        <property type="gene ID" value="BN770_01568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435656" evidence="2">
        <location>
            <begin position="26"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="336" mass="36296" checksum="057E899E5EF2C4F6" modified="2013-07-24" version="1">MKHKCLCSILLILTMLSTCWTYSVAEEMSDAFTSGDYEYIILDDGTVKITKYNGSAQELAIPYTLDGKKVTSIGNRAFSACRSLTSIFISDSVSQLDKLAFFGCRFLKSFAVSPDNPYFAAIDGVLFCKSNKSLISHPSSKESSTYNVPQGVLSIDDYAFFDCNFLTSVILPDSLSFIGDYAFASCSSLSSIFIPNSVTTIGECAFISCSSLSSISLPDSVVSIGSHAFQFCDSLSTISLPNSITVISDWSFSICKSLSFVSVPDSVTTIDASAFSGSSSLISIIIPDSVTEIGENAFAYCPNLTLTVLRNSYAAEYAKANNIPYTYPNANDWLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9E4</accession>
    <name>R7I9E4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47137">
        <property type="protein sequence ID" value="CDE47137"/>
        <property type="gene ID" value="BN770_00077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="154" mass="18050" checksum="C2887B2601AA0151" modified="2013-07-24" version="1">MLTLYEPKYEDLWFRQMMLADEDTMSYNHAWGGTIPFGEDKWRGWYDCWIADPDGKRYYRYLKNEDGQFVGEIAYHYDAEMQQEIANVMIYAKYRRRGYGGEALDLLCSAAKSNGVSVLYDDIAIDNPAVSLFLKHGFVEESRTEEIILLKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9I0</accession>
    <name>R7I9I0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000091">
        <property type="protein sequence ID" value="CDE48230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48230">
        <property type="protein sequence ID" value="CDE48230"/>
        <property type="gene ID" value="BN770_01585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435601" evidence="2">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="72" mass="7308" checksum="5CB82421940038D3" modified="2013-07-24" version="1">MPVSQIAVGPSAPPMMPMAPASAAEKPNTAYAKMNVMKMPSCAAAPSSSVFGLEISGPKSVPAPTPMKIRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9L7</accession>
    <name>R7I9L7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47988">
        <property type="protein sequence ID" value="CDE47988"/>
        <property type="gene ID" value="BN770_01474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="164" mass="18334" checksum="1E2E10DE75DE52A4" modified="2013-07-24" version="1">MPEITIRRMTMDDVDGVYAVEIGTFVDAWSRDAFVSDMKNPVARYLVAEQDGKIIGYAGAWVILDESHITNIAVLKEHRGQGTGKRLTHGLLQYLSNLGAAYATLEVRRSNEIAQNLYKSLGFVQLGVRKRYYADNGEDALIMVCDHMPAADPDFTEAETVFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9S8</accession>
    <name>R7I9S8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase/vanadium-dependent haloperoxidase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47257">
        <property type="protein sequence ID" value="CDE47257"/>
        <property type="gene ID" value="BN770_01185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003832">
        <property type="entry name" value="DUF212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31446">
        <property type="entry name" value="PTHR31446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02681">
        <property type="entry name" value="DUF212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="153" mass="16862" checksum="CD526A9F1AF822A1" modified="2013-07-24" version="1">MELHNILGLFSNQVLLCCITAWFVAQALKIPTYYLVEKKWDWHRFFGSGGMPSSHTAFVVSLTLMIGATQGFDSAIFALSFTMAAIVMYDATGVRRETGKQAVVINEIVQKMFVNGESITDEELKELVGHTHVEVIGGVIVGLLTAGLFLLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA06</accession>
    <name>R7IA06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000108">
        <property type="protein sequence ID" value="CDE48435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48435">
        <property type="protein sequence ID" value="CDE48435"/>
        <property type="gene ID" value="BN770_01698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="286" mass="31570" checksum="476A4F728EEC8D20" modified="2013-07-24" version="1">MFQIGNERVALVTDTSCDLSDEQLSQYDIRTVALRVATSQGEFRDRLEITQEQLYDLLQREVPKTSLPLPEDVSNLYRTLHDEGATSILHLSISGSLSGTFNMVSLLAEDFEDMKIHVFDSKTLSCGLGLLVLEAAESLQNGMSVEDTIALLEKRREHQLGAFVIRTLEFLRKGGRIGRVEGAIGSLLQIKPVIYVNDEGVYNTLCKARGFSNALTAMVDEIIRRYQGHKVRLAVVHGAAYDDAVKLRDRLMERLDVVSSFISPVSPALAIHTGPGLLGAIVQLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAE3</accession>
    <name>R7IAE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000122">
        <property type="protein sequence ID" value="CDE48859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48859">
        <property type="protein sequence ID" value="CDE48859"/>
        <property type="gene ID" value="BN770_01843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="34724" checksum="0112769F9AA0D09F" modified="2013-07-24" version="1">MSKQTPKQQSLCNNKFDGLMNAAPHKRYKSFAATVADWESVWLDCDPNQPLPEEGVISVWPEEMFAAAVCTDKPFFKMDVHDFCDLLGAHPDATIRVFPNGKNWTDTAAEDLLEDVLEGLAEERIAAKEGEIRLVLGDMQVDGVQPSHGDDAAEQIADAALDVNQPGNQSGDAARRAADEQRQPRRNALEGQRGGDRRAQREGAVDGQVGEIQNAVGDEKPHCHNAIDEPLLQNADEHVQRHNQSPRCVDVCGERNCIIIGRKPGHARPFRLREGSRKERRGNGLFTLPSRRWRVRTVPRGRSDRMPPAHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAJ9</accession>
    <name>R7IAJ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="9" type="ORF">BN770_01863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48924">
        <property type="protein sequence ID" value="CDE48924"/>
        <property type="gene ID" value="BN770_01863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="135" mass="14463" checksum="96570AC45413AA4F" modified="2013-07-24" version="1">MAPKQQSKLKKVVRKRKERKLVERGAAHISSSFNNTIVTITDTQGNALSWASSGGLGFRGSKKSTPFAAQTAAETAAKAAMEYGLKTVEVYVKGPGSGREAAIRSLQAAGLDVSMIKDVTPIPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAV6</accession>
    <name>R7IAV6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000055">
        <property type="protein sequence ID" value="CDE47637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47637">
        <property type="protein sequence ID" value="CDE47637"/>
        <property type="gene ID" value="BN770_01319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="171" mass="18410" checksum="F8D096D1FC27AF51" modified="2013-07-24" version="1">MTNITNPYLSAEAVAKKKTDIPVVLVCAIFAVATVSATITMFSQGKTLSGVMGIFLFAALITPVFRILRHAYRRACARRIAGALLPLTEESLTFDQLGTVLSSSRALEQLRSLIGTGYLQNLQINAATRTVALYTPEGTFVQWICPGCGAKNSGRRGSAPRCTYCGQPYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB05</accession>
    <name>R7IB05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000057">
        <property type="protein sequence ID" value="CDE47687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47687">
        <property type="protein sequence ID" value="CDE47687"/>
        <property type="gene ID" value="BN770_00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="164" mass="17533" checksum="A370798F6AC34198" modified="2013-07-24" version="1">MEKWMKGRYMANQKRLSVGTGVPAPRGRGIVMLILLALVVALAAVSVTTVAKLSSVNSRNIAMMQEQCRDAVALSTTLSRTASSSSAATVGKIRADVHAIDVINQMKMLQDGTNHAYVSTELISRIYTILDAYSNQLITGMSTMEEQTNLSAALQELSAALSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB06</accession>
    <name>R7IB06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetylhomoserine (Thiol)-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48676">
        <property type="protein sequence ID" value="CDE48676"/>
        <property type="gene ID" value="BN770_01785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="382" mass="41224" checksum="0BB57A8CD2FC1DBF" modified="2013-07-24" version="1">MSDYRIETKCVQAGYTPGNGEPRQIPIIQSTTFKYATSEDMGKLFDLEASGYFYSRLQNPTCDHVAAKIAALEGGSAAMLTGSGQAANFMALFNICEAGSHIVASSSIYGGTFNLIAVTLKKMGIESTFVSPNATDDELDRAFRPNTRAMFGETIANPALTVLDIEKFAQAAHRHGVPLIVDNTFPTPVNCQPIRWGADIVTHSTTKYMDGHGAALGGVIVDSGNFDWMAHAEKYPGLCTPDESYHGITYAEKFGNAGAYITKCTSQLMRDLGCVQSPQNAFILNLGLESLHVRMPRHCENAMAVAQFLEKQPQGAGGSYPQFPRKPAAGGVRQLSAPAVQPVLRPRDEVHAERRLRGGVVRLEGWTSRCGGIHETADFGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB13</accession>
    <name>R7IB13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000135">
        <property type="protein sequence ID" value="CDE49099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49099">
        <property type="protein sequence ID" value="CDE49099"/>
        <property type="gene ID" value="BN770_00146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="281" mass="29584" checksum="61F4E1A0BCFC716B" modified="2013-07-24" version="1">MMKLPLNVDFTGKVVVVTGAGGVLCGEMARAYAQAGAKVAALDLNEEAVKKLADELTAEGFICKGYKANVLDAEALEAVHQQVLADLGPCDILINGAGGNNPRATTDNEYQHEAKEGQKTFFDLEPNGVDFVFKLNFQGTLLPTQAFAKDMVARKSGNILNISSMNAYIPLTKIPAYSGAKAAISNFTQWLATHFAGTGIRANAIAPGFLVSNQNRALLFNADGTPTARSAKILNGTPMGRFVDSKELLGGVFFLTDDEAASAITGVVLPIDCGFAAYSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBG3</accession>
    <name>R7IBG3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolysaccharide biosynthesis protein putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48648">
        <property type="protein sequence ID" value="CDE48648"/>
        <property type="gene ID" value="BN770_01769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448131" evidence="1">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="2">
        <location>
            <begin position="110"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33129" checksum="4168669EA6A766A5" modified="2013-07-24" version="1">MRKVLALLLSLLMLTPALAEETVITPLPMGLTDTGYTPDPNAFIAADEENGVLQGYQDDSITVTLWRETVGDATYNVARVKIADPSQFRTGLNHPKARTDNKISAIAEKHNAVVAIGGDYFGKDDYGYVVRMNEVFRKKPSKQRDMLLVDNNGDFHIILQSDADELKALLSSDTLTFPNVFNFGPALVVDGNVCEIPDYYKNKYNVFADEPRCAIGQIGELEYLLVVVDGRRKDSDGCTCAELADFMAKQGCTMAYNLDGGNSALMWFGGENYSEKTVKAERSVSDIIYFATAIDAANTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBT3</accession>
    <name>R7IBT3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">BN770_01462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47972">
        <property type="protein sequence ID" value="CDE47972"/>
        <property type="gene ID" value="BN770_01462"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="420" mass="44746" checksum="0395253C21ABD92A" modified="2013-07-24" version="1">MEAFVVRGGRKLEGTMCVDGAKNAALPILAASVLTEETVVLQGVPMISDVRKMTDILTMLGCRIRRDGHTLTLDAGGLNRTEMPDALSKQIRSSIFLLGPILSRFRQTTVTYPGGCEIGLRPIDLHLSGLRSLGVVIHEEGGVIHCDGGNMHSGEVHLDYPSVGATENILMAAVLLPGISVIHNAAREPEIVDLANFINAMGGSVRGAGSAVMTIEGVKHLHGARWTPMPDRIVAGTLLAAGAITGGTIELTRAPVQALLAVNAKLREMGCDVREEEKRVILTAPERLTAFAQLQTQPYPGFPTDMQVQMLALLSVSEGTGVVVENVFENRFTHAGDLNRMGARILCSGRTAVVRGVPELYGARVTARDLRGGAALTLAGLKAQGETQVDGAELIDRGYEHFETQLTRLGADIRRVQGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBZ4</accession>
    <name>R7IBZ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">V-type proton ATPase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49399">
        <property type="protein sequence ID" value="CDE49399"/>
        <property type="gene ID" value="BN770_01999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="201" mass="22170" checksum="877174002688911D" modified="2013-07-24" version="1">MNANAIQEKILSDARTSASDIMRDANEKAARLRDAAEKRMAAAHSRLMMQASEDAEAARLRMERMEELEERKRLLSDKRALIDEAFAQALDKLEAMPSQQARAFLMTEAAAVADGDETVILGSKNPGWFDDKFLADLNTLLQKQGKPGQLTLGNETRDGETGLILAKNGMEISCTFASLLDSRRLDMEADIAAILFPDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC39</accession>
    <name>R7IC39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49061">
        <property type="protein sequence ID" value="CDE49061"/>
        <property type="gene ID" value="BN770_01905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="424" mass="45843" checksum="644052BE4CA0115E" modified="2013-07-24" version="1">MDQNKWLRRKPQSNLDYLGITLIAVAFYMALLNAQSFLNGVNRILGILAPFAGGVVIAYCLNPIVKASMKYLFRGREKCRGLAILLAYIVGLAIVALLMVLIIPQMVGSVVMFYQNFDGYAQNLLNMLKELDAETPGVDLSLAVTAVENLNASMSDLLGTIVKAITNRVPQIISYVGGVASGVVTIFTAIASSVYLLLQKDKLLRHARVLTRAFLPKSAAETTLRICHDANRNFGGFFAGKILDSAIIGVLTFVSMNILGLSYATLISIIVGITNIIPVFGPFIGAIPGAVILLFLDPWQALIFLILILIIQQLDGNFIGPMILGDSIGISALWVLFAIVVGGDLFGLVGMVVGVPIFATIYGILRSAARHGLRQKGYTDVEESVSASAAGDEIPDDPRESGHRMSLLRQWKEKIMSIGKKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC41</accession>
    <name>R7IC41_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000138">
        <property type="protein sequence ID" value="CDE49160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49160">
        <property type="protein sequence ID" value="CDE49160"/>
        <property type="gene ID" value="BN770_01923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="175" mass="19603" checksum="574A9AC99621A430" modified="2013-07-24" version="1">MPVFPRTFREKQALQQARTMAALCASSHPQGRRFPVHRQVSRLGFLRRSTFPAIFSPVAAPIFLGTRSLVCFTVAGTAPVLHRLPMFAEHARVRRRASLRTCVGCSFVTDIIHADGALVNLLRFLDTFPAICYNSDGRNRSRGFHPFSLHIISHTRCDFPCARGVSPCNKSHQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC54</accession>
    <name>R7IC54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49076">
        <property type="protein sequence ID" value="CDE49076"/>
        <property type="gene ID" value="BN770_01914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024208">
        <property type="entry name" value="DUF3842"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12953">
        <property type="entry name" value="DUF3842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="139" mass="14009" checksum="066DD9229336B110" modified="2013-07-24" version="1">MKIVILDAQGGGMGRQLVEGLKKALPNQPLIAVGTNALATAAMLRAGADQVATGENAVVVCAGMADLILCPIGMVLCDAMLGEVTANMALAVGRSRAHKILLPVSRCQASVAGAPKMSMAEVVAKAVEETVARVSAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICF9</accession>
    <name>R7ICF9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="10">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trmFO</name>
        <name evidence="12" type="ORF">BN770_02045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49574">
        <property type="protein sequence ID" value="CDE49574"/>
        <property type="gene ID" value="BN770_02045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="11">
        <location>
            <begin position="7"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="440" mass="48394" checksum="D6D3B425B55FB343" modified="2013-07-24" version="1">MSNLHATVVGAGLAGSEAAWQLARQGIAVTLIEMKPEKMSPAHHSPLFAELVCSNSLRSDRLTNAVGLLKEEMRLMHSLVMEAADLARVPAGGALAVDRETFSGHITKSLREHPLVEVVSGEVTEIPDGPVIIATGPLTSDALSETISRLPGLETLNFYDAAAPIVTAESLNMDKVFRQSRYDRGDDYLNCPMTEEEYNAFVDALLAAETADIHGFEETKVFEGCMPVESMARRGRMVLAFGPMKPVGLRDPQTGKEPYAVVQLRQDNATGTLYNLVGFQTRLKWGEQKRVFGMIPGLENAEFARYGVMHRNTFLHSPGFLNAHFEMISRPQCYFAGQMTGVEGYVESAASGLLCGLSLGRDLRGLGTVELPGITAMGAMGRYVSTPNRDFQPMNCTFGLLDGLLVDKQHKKIRNKQERYTVISERSLSYLRDWVTEMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICY4</accession>
    <name>R7ICY4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase LytS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000104">
        <property type="protein sequence ID" value="CDE48407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48407">
        <property type="protein sequence ID" value="CDE48407"/>
        <property type="gene ID" value="BN770_01688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="476"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="605" mass="67755" checksum="CC46F98A0B742846" modified="2013-07-24" version="1">MRKHFSSLRSQVTLLTTGTVLAVVILATVFYSSAQRMSEKKAATFVHSMLVQLGDSLDRIGNEMSYLGNALHSNEVLQQYYHAPTAIQRMQYGKSFIDFTSSLLNHSTTVSHIVIVNNDQSILSPTERNIIALDTLDSKYHLFKSDNLSSGFYGPAFDTFTNRNFFAYVQPVYNTRQGARFRQKLGTCVIFARLDLLQSTLRSALPTPGAALMLIEQDEQIILCCDADGNTLSLLPESFCSDMADGLQHSLTLNKTTYLTDSLLLSSMGWRLVSLVPEDEIAADLMPLLWLGMLICVVFAICIGVWNLHIQRSIMAPVKQLTAFIENDLDDKLQNRIHISTSSEMELFCQEINTLLDKVSEMTAERLQDQTRLYELNLAKKRAELSALQSQINPHFLYNTLDCIRGYGYMLNSSEIVSITNALSSIMRYCIKGADIVALRKEMTIVNYYLDIIRIRFPNRFNYVFDVDPALEDLAIPRFILQPVVENAIYHGLESRLEKGTLTISCHTTETGDCALCVTDDGVGIPPERLAEIHRKLSDKSMQNVLNVPAGNSLALVNIHNRLRNLYGANYGLDIVCPPEGGTRVTLHLPMVLVQTETEQGGHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID09</accession>
    <name>R7ID09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000108">
        <property type="protein sequence ID" value="CDE48442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48442">
        <property type="protein sequence ID" value="CDE48442"/>
        <property type="gene ID" value="BN770_01704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="245" mass="26310" checksum="099E29E7C88806E9" modified="2013-07-24" version="1">MTLFLTSSPCDNNVPEGLDLPCIFDARNGFVENLRASVEPGAQLLIIASDPDAFAGNDEMAATFEGCFAAAEIELEDVCVLDSRNADDAAELVAQSGVILLSGGHVPTENAFFASMDLRDLLADFDGVIIGISAGSMNCADTVYAQPEEPGEAVDPDYQRFIPGLGLTTRNILPHYNQVKDNVLDGLRLFEDITAADSAGHTFYILPDGSYILARDGEEMLCGEAWLMHNGVLEKLTEDGEELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID72</accession>
    <name>R7ID72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49238">
        <property type="protein sequence ID" value="CDE49238"/>
        <property type="gene ID" value="BN770_01953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009296">
        <property type="entry name" value="DUF951"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38455">
        <property type="entry name" value="PTHR38455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06107">
        <property type="entry name" value="DUF951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="82" mass="9349" checksum="F4DFA30F0070E806" modified="2013-07-24" version="1">MAQANPKIVLEEKRMDLNVEIRLGDVVQTRKQHPCGSNEWTVIRTGADIKIKCSGCGRIVMMDRETFLKRRKKLISQGPEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDN6</accession>
    <name>R7IDN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipopolysaccharide biosynthesis proteins LPS:glycosyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49934">
        <property type="protein sequence ID" value="CDE49934"/>
        <property type="gene ID" value="BN770_02195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="336" mass="38726" checksum="C5A55D4E9C06AAE9" modified="2013-07-24" version="1">MDIVYSSSDSYCEIAGISILSLLEHNRNVKELNLYLIDNQISAENKQKLENMIASFGRTLTYLAHPDIEKRSATEINVGRWNISTFYRLFLPSMLPETVKKVLFIDCDTLVMQDLTPLWEMDMGDKWLYGVDDCRGAAYRTNLGLQPTDNYINNGVLLVDLDAWRKNNVEDMFLRYIRENQGDITFVDQGVQNGVLSKLGRSGILHPKYNCMTVFFAFDYKNLIKLRKPPVPGDPAQYREAVENPAIVHFQSCFRMSIRPWVEGCKHPYAKTYLAYKAKSPWKDTPMKPDDRTAPQKVLSAVTSAMPERLMVDCISFVHTKIYPLARNLKQRMNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDW8</accession>
    <name>R7IDW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HglK (Pentapeptide repeat protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49636">
        <property type="protein sequence ID" value="CDE49636"/>
        <property type="gene ID" value="BN770_02064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="8"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="253" mass="27765" checksum="0732828B6BF250F9" modified="2013-07-24" version="1">MTFDLQRANVWKRISAFLFDVILLAIACVLCAWGLSALLGFDAQYQTLMARYQAAADACGLDMSIMTQTYSTLTDAQRALVEQANAVLAADETAVHAYGMVVQLSILIVSFGVLSGYLLLEFLVPLLFKNGQTLGKKIFGVALMRNDGVRIGHVTLFVRTVLGKYAVETMIPIMAVMMLFFGNLNIVVLGIVLILSVAQFVLFLATRKHSLIHDLLADTVAVDMASQMIFNSTDELVAYKAKLQAEKVAHQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE05</accession>
    <name>R7IE05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49845">
        <property type="protein sequence ID" value="CDE49845"/>
        <property type="gene ID" value="BN770_02161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="287" mass="30998" checksum="C511B615E4C8D57B" modified="2013-07-24" version="1">MNLQMPIRLIATDMDGTLLTDEPLILPETADVLRRAAEKGIVLSLASGRLPDDASFFAVDAKLPMHVIALNGAVTLVKPLGDVQEAHHLPQPTVHRITARLDEANVQYAVFGVHEVVASNDMPLSRAQVLIGTFLNRAGGRTAFRNQKQGIDAVIQDCVKVVVFSQNLPLLDDLRAFVRDRCPDADVTSSWWDNIEIVPRSASKGSALQALAKSLNIPMDEVMVFGDSDNDLSMLKAAGVSVAMGNANERVRASARFETLTNDAQGVAAAIRAIVFGEDVPGVIRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE47</accession>
    <name>R7IE47_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Primosomal protein N'</fullName>
            <ecNumber evidence="10">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">priA</name>
        <name evidence="13" type="ORF">BN770_02275</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50099">
        <property type="protein sequence ID" value="CDE50099"/>
        <property type="gene ID" value="BN770_02275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="219"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="487"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE50099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="751" mass="84008" checksum="F11A80105F77A11C" modified="2013-07-24" version="1">MSVLYAQVIVDIVHENVAHTFTYRIPDGMTLTAGQRVEVPFGRMRKEGVVLSLTQETDVPPEKLRDILRPLEDYAAICPTLLTLAQQMADDVHCPLAETLRLMLPAQMRGGRIQVKTQTVAQAAKPREMLEAAALAEKRSPKRRLLLTVLSDGRTHPVEELKLLVREPLQALRQIEAAGLIALREEEVLRRPGGNTPDTAVPDPPLTPGQEEALSVMLPDLRSGQGKYLLHGVTGSGKTEVFIRLVRQTLVQGKSAMILVPEIALTPQMVMWFRARFGAVAAVLHSRLSAGERFDEWRRIRRGDARVVIGARSAVFAPCGNLGLIVVDEEHESTYISDRHPRYDAREVAIRRCENEHATLLLASATPSILSFARARRGDYVLLEMPCRVGNRPMPQVMLVDMRKEMENGNRSVFSGQLVAALKNCVARGEQAMLLMNRRGYNSFVSCRSCGYVVKCPNCDVAMTYHVVGSGQTEAKLHCHYCGFAALPPNTCPKCGSKYIRYFGAGTQKIEEELKKLFPQENVIRMDIDTTSGKDGHAKLLDEFRSGRAKLLVGTQMIAKGLDFPKVTLVGVIAADMTLNLPDYRARERTFQLLTQVAGRAGRGTLPGQVIIQTYKPEDEVIQTAAAQDYRAFFELEFDRRRTGLYPPFTILARLLVESNSPQKAREVATMLHARCEELLNAHPQWKKRALMVRLDQPSITVLRGKTRWHVLMKLLVHPETEQFAAALSELAREKQEGAEVYFEYNPTTMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEH9</accession>
    <name>R7IEH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49821">
        <property type="protein sequence ID" value="CDE49821"/>
        <property type="gene ID" value="BN770_02149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014194">
        <property type="entry name" value="Spore_III_AE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09546">
        <property type="entry name" value="Spore_III_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="300" mass="31490" checksum="2FC02BC4335350A5" modified="2013-07-24" version="1">MLSRQFFSAVRQSLWRLTRLIAPALLWALLKQFSGRSSECGRIVVQLFVCVFLTQDLSDHITLAVATVQQISAGMQGLLPMLLTMMAAVGGSAGSALMQPAVVASASAMTSLISGITVPLAVASGVLCMLCHLGDGIRVQRLAEFTQQCAVWSLGIGFTVFIGVLTTRSVTAAAIDGVTLRTAKYALNNLVPFVGGLFADTVDTLVGSGMLVQSALGVTGLIVIASRAVLPLCQTLAAAMLYKLASALMQPVSDGSLAGCIHDFAKVLMLLFVLQLSAAAMYLMLIAQLIAVSGFTMMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEK1</accession>
    <name>R7IEK1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage antirepressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50065">
        <property type="protein sequence ID" value="CDE50065"/>
        <property type="gene ID" value="BN770_02266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003497">
        <property type="entry name" value="BRO_N_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02498">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01040">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51750">
        <property type="entry name" value="BRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bro-N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="88" mass="9548" checksum="7BAE1F44531C6F6B" modified="2013-07-24" version="1">MRTIVADDKVLFCGSDVARALGYAKPQNAIAQYCRNSTLKTPALNQGTNNEGANRTRLYIPEGNVYRLIVSSKLPGACPFTFPGEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEK2</accession>
    <name>R7IEK2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MBG_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49017">
        <property type="protein sequence ID" value="CDE49017"/>
        <property type="gene ID" value="BN770_01893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041286">
        <property type="entry name" value="MBG_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18676">
        <property type="entry name" value="MBG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="234"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="601" mass="65318" checksum="9AAA7EA5CE0EF397" modified="2013-07-24" version="1">MTERCSSGGSATYFDGTLQLWGFGDLTGQDIAATDGETVYSAVIAGKSSSAVTGLEISDIAATDNEDGTLTITFQTTGAKSAGVQVYAGEAPASMPDTYRADAKQYEADGNTVTISGLNTGDVVIYRVYASAEENVTLTESNADGFSFSEECFHVHRVKWVPSRTANTTYNAMTYRPRMTLPETASITYSGNNLVGGLPFYVGSYVMHVKIPEGDPLYLPGTVDVAFSIQKIPLTICPDANQQKNEGEADPARFTFTSIGLLDGDVVSGILKREPGEEAGNYNFVLTGLSAADYYTLRLMDDAPQFTILPTEPSWWGGGGERLNPVQQVIERSDGRKMFVTITTQEQLVLSYSELGSVVRNTADDQPRPFTPSLTWNKKTDEVLLRISAEAELNKDAGYVTDSYGNPVYGARTLRFGYMSLRYMNNAGIDAISFSNKNAAVILRLSDFLSADMEKAIKQAGGNLTTTLFRVTIEPVDLPDGAVTGGWNIRTEMVIDRKPTDISSLLPNAQVAVDMEVVAKLLTNLDRYDEKTFDKHFTLRRGAQTQESVFIAPYQDDELEKVAYPSVLFASRYLLMPLTESGVVDVVMVPIEEDAADGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEU6</accession>
    <name>R7IEU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pseudouridine synthase RluA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49843">
        <property type="protein sequence ID" value="CDE49843"/>
        <property type="gene ID" value="BN770_02160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="2">
        <location>
            <begin position="80"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="288" mass="31951" checksum="6CDD0BF5BBC7AF4B" modified="2013-07-24" version="1">MKYTFQTDSAAEGLRIDACIRRFLPELPSRAAQEAFSHRDVKLDGKRVKPDMRVHAGQCVEVFCMEQTAPLLDVVYEDADVLLVNKRAGISVEADKKGGVTLTELAARHVRQQAPDARAPKACHRLDNQTCGLLMFAKTEKAEGILERAFRDRTMDKRYICLVRGMMKPPKATCRAYLLKDAKAAHVTIHDSAVPGARPIVTAYETLEQGAVSRVEIHLITGRTHQIRAHMAALGHPLLGDDVYGDRAFNRQMKMQGKLCLCAAQLTLDTGGALPQLDGRTFRVKCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEZ0</accession>
    <name>R7IEZ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Chaperone protein dnaK</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BN770_00179</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50364">
        <property type="protein sequence ID" value="CDE50364"/>
        <property type="gene ID" value="BN770_00179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="487"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE50364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="602" mass="64707" checksum="CF7251BC0EA0C77A" modified="2013-07-24" version="1">MRKCGFMGKIIGIDLGTTNSCIAVVEGGSAIIIPNDKGERTTPSVVAFTDSGERLIGSAAKRQAAVNADRTIASVKRHMGTDWRKTIAGKSYTPQEISAMILRKLKQDAESYLGEPVTDAVITVPAYFGDIQRQATKDAGRIAGLNVRRIINEPTSAALAYGLNNGAPQKIMVYDLGGGTFDVSIIEIGEGVIEVLATCGDNHLGGDDFDERIVNFVCDAFQREHHADLHRDLAAMVRVKEAAEQAKKELSVTEMTTISLPFISTVGGQAVHLEQTLTRAKFNELTADLVARTEGPVRSALSDAGIAASELGKVLLVGGSTRIPAVQEKVRQLTGIMPSKSINPDECVAQGAAIQGDTLNEHTTLTNSTGLLLLDVTPLSLAIETVGGIATRVIERNSTLPVHYQQVFTTAGMFQSSVEINVLQGERPMARDNKSIGKFRLKGIRRAMAGVPKIEVTFDIDTNGILTVSARDQDTGRAQSITITADNKMSEDEIQQAIRDAEQYAAQDAFRRNLMDTINQAQHLLAQVSAALNQCSKQLDKDEKKRVKDDEAALRHLIGRAKPDKMAANDLSAIKSAMSTLESSSAHLMSLFDPNAQSGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEZ5</accession>
    <name>R7IEZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C69.002"/>
    <dbReference type="EnsemblBacteria" id="CDE50021">
        <property type="protein sequence ID" value="CDE50021"/>
        <property type="gene ID" value="BN770_02235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435807" description="Dipeptidase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="512" mass="54955" checksum="53E8A769A427009C" modified="2013-07-24" version="1">MAHLNAKKLFPLFLALALCLTSVNALACTAVYVGSDLTADGTTMFARSEDISNSYNKLFYAIPAGVHTAGEVYNGCYGFTYTFTKDSYAYTAFRDDNGAAKDGVCPDCGQTHAHTPYEAGGTNSMGVSVSATETIGCSDAMYEVDPYTDEGIEEAEITTVLLSESATAKEAVELLLSIYDSVGAAGGSGIFIADDKEVWYVENASGTQYVAVKLTSTMAFSQPNMSVIGLIDLDDTENVMASANLIAVAEQAGSYVGDKEANTIDYAASYNADQGVGSRMVNALKYFNAATAKEEPDYADFAISNVAADGSIVPMYTNITLDHAWSVADVVGYYHIAGIGSTRNLETHIFQVAKEDSITDTVEWVAMDDAALSVFVPYYPMLTTDTYAGYQLSTAAADFVEAQPESGVYYATTKNKRNENGERVKVEGFCVLPENWADSVYWTMDALSNLYEYGTLTDEEKAQVETTLADLQAECYEVYNQLKADPDNATAISAAAAQKVHEACVALVNSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF56</accession>
    <name>R7IF56_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHAP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50439">
        <property type="protein sequence ID" value="CDE50439"/>
        <property type="gene ID" value="BN770_02394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436505" evidence="1">
        <location>
            <begin position="25"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="3">
        <location>
            <begin position="68"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="223"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="310" mass="35162" checksum="7535892D4A04DEB7" modified="2013-07-24" version="1">MKRLLSLMLTLLLTAGLLLPCAKAEDTVLEPLWHVPDYVQWLLDVARGEIGYKEGPHGYSKYGEWAGDAYAQWCAEFLCWCVDQVDQQHGTELLRNVYPMYSGQNVGRDWFIRQGRYVTRNGNLANWGYQWMKDDDTYITTGTYIPQPGDWVFFTWTSSTDTDHVAMVEYCSQDATGNITVHVIEGNTPVAVKRAEYALTYNRILGYGTVHDVADWTMRSGNSGQKVRELQEKLSYLGYLAEDKVDGVYGAATVEAVKAYQGKKGLKTLGIANIDTQKALNDEYRLRLYTDPNAWAGVVDDNEEDDDLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFC7</accession>
    <name>R7IFC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50300">
        <property type="protein sequence ID" value="CDE50300"/>
        <property type="gene ID" value="BN770_02355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28400" checksum="B3F275FFAFEC1A82" modified="2013-07-24" version="1">MPTPYFEVAHLTKHFSTNESTVAAIQDVSFSLQKGQFLSILGPSGCGKSTLFNLIAGLMQPDCGDIRLQGESMLLRPGLTGYMLQKDLLLPWRTIADNIVLPKTLHGTRRQAALKSAVSDIAACGLRDLLNRRPDECSGGQRQRAALVRTLQTGKPLLLLDEPFGALDAITRLHLQALLTEIATKKHLTILFVTHDVDEALLLSDAILVMGTAPGRILRQYTLEEPRPRTMRVLSQPEFIRVKGEILTLLDKEVTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFD1</accession>
    <name>R7IFD1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_02356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50305">
        <property type="protein sequence ID" value="CDE50305"/>
        <property type="gene ID" value="BN770_02356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="780" mass="87740" checksum="BFE1551E11CDC140" modified="2013-07-24" version="1">MMNAKELLRQTESLLLQNDHITLAEASATQLHNALSTAAMNALTPTWVKCEAKRQAHRQAYYLSAEYLVGRMVYNNLFCLGLLDDVKALLAEKGVDIAILEDIEDDAFGNGGLGRLAACFLDSAVTTNVPLTGYGLRYRYGLFKQTFVNGYQHEEPDDWSRFGDPWSIRRVDQAVVVKMKTGDVLAVPYDMPIIGYGAKNIGTLRLWQTESLHEIDFTAFNNQHYAQASADKNKAEDITKFLYPNDDRREGKQMRIKQQYVLVSASLQDMLRAYKKRHGDDYAWFAEEHAVQLNDTHPVMAIPELTRLLMEDGFTFDAAFEIVRNVFAYTNHTVMQEALEKWDLALLASVCPELVAIIRKIDAKFKADMAARGAEVKATRCIIWNNQVHMAQLAVYATVATNGVAAIHTEILKDDVFADWYALYPERFQNKTNGITQRRWLGLCNPELTALIEKHIGSGFLTDLDKLEALKPQISDDLCREFIAVKKEKKAQLAAEIEKREGVKLDPNMIFDIQVKRLHEYKRQLMNTMSILHLYFCLKDGTLTDFTPTAFIFGAKAAPGYARAKAIIHLTNMVADMVNNDPDTSSLLKVVFVHNYNCSWAEKLIPAADVSEQISTAGTEASGTGNMKLMLNGAVTLGTYDGANVEITEQAGRENEYIFGATVEEINALKKNGYDPRAIYKADKEIARVLDTMVDGTFPDPDGAIKELVSSLLLGASWHKPDHYFILHDFHSYVDAKLAVNRDYRDELSFARKCLMNIASAGMFSSDRTIAQYAKEIWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFH8</accession>
    <name>R7IFH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type transporter duplicate ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49317">
        <property type="protein sequence ID" value="CDE49317"/>
        <property type="gene ID" value="BN770_01967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="329"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="634" mass="71986" checksum="D3158134CBDEBDDD" modified="2013-07-24" version="1">MILLSLQGIQKSFGTNEVLRDASLVLQDGQRMGLVGVNGCGKSTLMKIIAGIETADGGTMTMQKGLKLGYLAQQGQVGEGRTVLEELESVFEPVQRMEQQLRDLEHQMADAHDEASLHRLGSQYDQLTRRFEESNGYGWRSTVQGVLAGLGFRKEQQGQMASLLSGGERTRLCLGRMLLTEPDVLLLDEPTNHLDLKSIAWLEDYLRTYRGAVLLISHDRYFMDHVCDRMCELLLGATECYDGNYSAYMVQRTERFEIRMKAYELQQKEIARQEAIIARYRQFNREKSIRLAESREKRLEKVERLEKPKDESAIHFHFDVRRRTGDDVLMIDELAKGFSGRTLFEHVKMHLRAGDRVALIGDNGVGKSTLFKCIVGEEKPDCGTIRFGAGVDIGYYDQHQAHLHENKTVLDEVWDDFHRLDQTEVRGALGLFLFTGDDVLMPISTLSGGEKGRVALTKLMLKKDNVLLLDEPTNHLDMDSREVLEDALENFPGTILAISHDRYFINRFATKVCVLEAGGVKEYLGNYDDYFEKINRLQAPDSENAGMTKTAMDKEKRKSREEEKRIREKKNAIAAAEKAIATAEEEAAEMEAQLADPATYQDAEKAAQLAKAYQLKKDEIERRYAEWEELSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFL9</accession>
    <name>R7IFL9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="8" type="ORF">BN770_02454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50604">
        <property type="protein sequence ID" value="CDE50604"/>
        <property type="gene ID" value="BN770_02454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="212" mass="22991" checksum="6FFBD57DACA879FD" modified="2013-07-24" version="1">MKKAIVGKKIGMTQIFTEDGRLVPVTVIKAGPCTVVQTKTVESDGYNAVQVGFGELTEKRAEKLLSKPVQGHYKKAGVEAKRVLREFRFDDCSGYKVNDVLKVDQFVAGDKIDVTGTSKGHGFTGPVARWNQHTGPMAHGSKYHRGVGSMSANSDPSRVFKNKHMGGHYGVDRVTVQNLEVVSVDAERDLLLVKGAVPGANEGLLVIRDTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFV3</accession>
    <name>R7IFV3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">BN770_02421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50500">
        <property type="protein sequence ID" value="CDE50500"/>
        <property type="gene ID" value="BN770_02421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="160" mass="18098" checksum="FD01170D2354EA0C" modified="2013-07-24" version="1">MAKAELTTVVTPKCQRLADEMGYELVDVCLDKENTGKFLRIYVDRPEGMSLDDCERYHRAIMPLVESYDFDFLEVSSPGIDRPLKKDRDFERALGEEVEVHLFKAVDGQKVFTGILSDFDAQDMVLTIAGEEKRFARKAASLVKPVVDMEGVEDVDLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFW9</accession>
    <name>R7IFW9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Manganese/zinc/iron chelate ABC transporter family permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50336">
        <property type="protein sequence ID" value="CDE50336"/>
        <property type="gene ID" value="BN770_00163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="279" mass="29234" checksum="434AEDA7B18335CD" modified="2013-07-24" version="1">MDAIRAFVQTLLPFEFLQFDFMVNALLAILLLTPLLGLLGTMAVNQQMAFFSDALGHSALTGIGLGILLGVSSDLLAMLVFGIVWALLICRIKQTGAASTDTIISVFSSTSVAAGVLVLSMGGGFAKYSSLLVGDVLAVQDSDLLYLLIALVAGIALWAVMYNSLLLSGISPSLARSRGIHNRLVECAFVVLVAVAVMLAIRWVGVMLINALLILPAAAGRNLARSSRQHAVYSVVIALVCGVAGLICAYYLDTTAGAAIVLFAAVCYAISLGIRALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFY9</accession>
    <name>R7IFY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50366">
        <property type="protein sequence ID" value="CDE50366"/>
        <property type="gene ID" value="BN770_00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="104" mass="11213" checksum="7CB7E7B9A2AD63BA" modified="2013-07-24" version="1">MTANFPIYLLVMAGVTYLIRMLPLTIFRKEIKSTFVKSFLHYVPFAVLGAMTIPDVLYSTGDMRTAAVGLVAAVFLAWKGKSLLTVALAACAAVLAAQGILLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG40</accession>
    <name>R7IG40_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsS</name>
        <name evidence="8" type="ORF">BN770_02450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50595">
        <property type="protein sequence ID" value="CDE50595"/>
        <property type="gene ID" value="BN770_02450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="92" mass="10269" checksum="1E7D9F9C250838BB" modified="2013-07-24" version="1">MSRSIKKGPYVESALMKRIVEMNKSGKKNVVKTWSRSSTIFPDFVGHTIAVHDGRKHVPVYVTEDMVGHKLGEFAPTRTFKGHAGDKATARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGD0</accession>
    <name>R7IGD0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MobA_MobL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MobA/MobL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50373">
        <property type="protein sequence ID" value="CDE50373"/>
        <property type="gene ID" value="BN770_00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005053">
        <property type="entry name" value="MobA_MobL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03389">
        <property type="entry name" value="MobA_MobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0184">Conjugation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobA_MobL" evidence="4">
        <location>
            <begin position="65"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="470" mass="55235" checksum="49FD667DB4882EFB" modified="2013-07-24" version="1">MARHSFIQMSKLPNVKGRISYITSHARQENLYATYRTADNAFWNNLARESRQEFQRSGAEGKCIEARELIIALPEVYTQYEPQQVLEDFTDEFRRRYGVECVSALHHNKRKTNYHIHLIFSERKLLPEPDVKIATRSVFFDETGKRVRTKKEITGEDGQIRKGCTIIKKGEVYESHLFTVKDDRFKREPFLREVKEDYTNLINLHIENPEQHLKVFDKNSVYLPTKKIGKNNPKAEEIAADNATRQEWNRTADMALVSGIEEAKILEIKQTEIHDKVSQSIKSEGWLPNLFRRIVNKAKDILQNLIREYGIPPKPTLDIDMTEFCTMRNLMIRVQDEARGIRNLQDNILPKLKTQLAETTGIFKGKERKALTEQIQQTEQEIDRRLDKLPDILREDGYPDVQAFMATYREAEAVVEQYNRDLAEWERQVKQKSRPPRPPEKEGVRNRLRQLQEQGRQQKPRKKSFDRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGE7</accession>
    <name>R7IGE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclodextrin ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50393">
        <property type="protein sequence ID" value="CDE50393"/>
        <property type="gene ID" value="BN770_02359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="109"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="318" mass="35333" checksum="B18EA31AE8C681D8" modified="2013-07-24" version="1">MSTTKYDHLPEQEKHAALAREEAAIKAEALRYHDKHRMTPAKVAKLTARHVVLALLAAFWLIPILWLVVTSFGVDKGPNLSTFFPKAYTLDHYKALLSPDSVNQFPQWMLNTFIVACFTCVISTLFVLMVAYAMSCMRFKARKPLMNIAIILNLFPGFLSMIAVYFIMKQFGLTGTLTGLIIVYSAGSGMGYLIAKGFFDTVSKSLRESAYLEGANEFTVFWKIILPLSKPIIVYTVINSFLAPWMDFVFADLMMTSGTAANKTVALGLFAMVNKVNRNNYFAQFCAGGVIVSIPISILFVIMQKFYVEGITGGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGI2</accession>
    <name>R7IGI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50433">
        <property type="protein sequence ID" value="CDE50433"/>
        <property type="gene ID" value="BN770_02388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="177" mass="19976" checksum="EDB792BA18385DA0" modified="2013-07-24" version="1">MSIAVYSARQTQQLFDLFSAMTDYYAGDPARINHFVKVHAYARQIGLAEQLDADTLFLLEAAALTHDIGIREAERLYGQCGGKLQERLGPPEAQKMLDSLGFAPDVTERVCFLIAHHHTLDGVDALDWRILLEADFLVNMIEEGMKADAIQCGREKIFRTEMGLRLMERLTEKKCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHC0</accession>
    <name>R7IHC0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000200">
        <property type="protein sequence ID" value="CDE51189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51189">
        <property type="protein sequence ID" value="CDE51189"/>
        <property type="gene ID" value="BN770_00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="282" mass="30126" checksum="A3082DF5A2229266" modified="2013-07-24" version="1">MMAEECTHDCSSCGSACASRQKPQSLLAPANAGSRVKKVIGVVSGKGGVGKSLVTGLLACETARRGKIAGVLDADITGPSMPRILGIHDKAVGNELGILPQEAENGVKVMSINLLLEHDTDPVIWRGSLIAGTVKQFWTDVCWGDVDCLYVDMPPGTGDVPLTVFQSLPVDGIVIVLSPQELVGMIVEKAVKMAQMMNIPVLGLVENMAYMTCPDCGKRLYPFGEGRTADVAKQYGLPMLAQLPIQPEIAKKCDEGRLMDIQLPEMGKAVDAVLKCKVRKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHF8</accession>
    <name>R7IHF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50032">
        <property type="protein sequence ID" value="CDE50032"/>
        <property type="gene ID" value="BN770_02238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="149" mass="16363" checksum="2BDFDDD7B812CCB6" modified="2013-07-24" version="1">MADLQTLRRTLLGSVIGLARTCTTRPPTETTPGLILAGLHLSDDAVSATPEQLIALNERIQQNKFEVSPNCATCASPCGKNADYDLRRLDDAPEDVRQAKMRLIALLQVCGHRGKMADCVMDAVFALAEDWDAADFKVYEEQLTELLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHG6</accession>
    <name>R7IHG6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S1C (Protease Do) subfamily peptidase MucD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50042">
        <property type="protein sequence ID" value="CDE50042"/>
        <property type="gene ID" value="BN770_02243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435938" evidence="2">
        <location>
            <begin position="34"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="319"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="433" mass="45516" checksum="300555D548F5DA89" modified="2013-07-24" version="1">MKFRKMMGCIALGLTCAMIGAGATMAAQNTSAAAEAVTAANSTTTVVTSPFTAAVQQVRNSVVGVSNYQTVRYGSYGNNFYFGYGFGYGNGRNNDQQIEEREELAATGSGVVIGQGFVLTNYHVVEDASSLRVTVTDDSGNTDEYAATLVAYDESLDIAIVYATGLDLPAVTLGDSDTLQVGDWAINIGNPLGFTKTTTVGVVSALNRAIESESYDKYGRKSTITNAMIQVDAAINSGNSGGGMFNVNGELMGIPTLKYTGSYYSGSTVEGIGMCIPINSAKPLINKVLSGEITFTAPEALDNSDDNKADSNTDSTLVGKPRMGITMSNLANSRALQNGQIPKGVYVVNVEENSPAEKAGMQVGDIIVDVNDNVITSTTELAAQVADCKAGDVLKIKVYRVPGITDLTGSDDIPDGEYIDLEVTLEVIDNVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHI1</accession>
    <name>R7IHI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000178">
        <property type="protein sequence ID" value="CDE50753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50753">
        <property type="protein sequence ID" value="CDE50753"/>
        <property type="gene ID" value="BN770_00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045725">
        <property type="entry name" value="DUF6079"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19557">
        <property type="entry name" value="DUF6079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1225" mass="139562" checksum="4BADF21384E0916C" modified="2013-07-24" version="1">MKYSDLISFHPIEDVIQLVTAENKDKAREYVKTYVMSDTMAESLQAPVLDQLQMDEVVDNKGVLIVGNYGTGKSHLMSVLSAIATDADNVQYLQNKKFAEQVKPIAGKFEVLRIEIGGVVMPLYDVIMGYVQDDFEKRGIDFEVPDYKSVKSIKTVVKDMMIAFSEKYPDKGYLIIVDEFLSYLSSRNEREIVLDLEFFRALGEMCSKSSLRVMFGMQEKIFDNPKFGFVADTLKHVSDRFTQMIITKEATSYVVSERILKKTPEQKALIRNHLEKFCGLYTGMSSRLEEFVDLFPIHPSYIDVFNKLYLIENRHILKNISTTIKGIFDTSVPENAPGIISFDNYWPAIKSNGLLKSDPTISRVVGASQQLEDIITRAFLKPAYKPMAMQIIYALSVHRLTTNGLDVQFGMTAENLKDDLCLYMMMPEQDADFLLSAVKVTLKEIMTTVFGQFIIFNDANSQYYIDVDKVVDYDEKIKQKATLLADDELNRSFYNVVYTCLDWDAKQYVTNFNIYEYDLNWDSHQIFRGGYLFMGLPGERSTAQPERDFYIHIMPPYDRSGVTVQNLPDEVYLYFKSAEKFRETLGMYASATSLAAISEGKDKEAYLNKANTIRKKLVRLLNDNKNTCFDVLYKHERRQLIEVLRGRDNRDMTFKDTIDMAASICFDGYFSEIYPEFPVMKTKITRKNMAEAVRAAFDHFAGRKSQLSTSMLQSFGVLDGDKISTKNSKYAAYYISKLKKLPPKGVINYSDIFDEKFMGDFEEKHFKLGFIFTPIIFLAMVYDGYAVMTLCSGKALTASNLDEVPKTNVTDLYEFKFLSRPSEMAMAELKALFGVLDINPALLDNQATRTKGVEELLKKAQVNSNAAVIANTKLSQDFTLWGEALVPQARVDQLKKACQNVRDEFSNYQARFNTPAKLNNFSLTMEQIDALAEDIADIRKINEYVIFKNNCTAIVSYMVSIETVELGDALKRDLETAKDAFREIRDDIWNGESGEVAAQRAEAELNKIKGKYIDLYYSEHKKKRLDIGDAQARGKLQEGRTLLSLKKLRSIDILSVAKLTDLENELSELKVCYELTPEELKSSPVCPHCHFHLDDNVKPVHGKLDNIESRLDALLEEWTKSLLDTVSDPLVASQKEFLGEEQQNVIDEFIETTALPKRVDDFFVKAIQALLKGFEPVVVDADDLVEKLTKLPPLDERAFRSKVNELIAGYTKGKDAGKLRIIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHI4</accession>
    <name>R7IHI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51229">
        <property type="protein sequence ID" value="CDE51229"/>
        <property type="gene ID" value="BN770_00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="337" mass="39258" checksum="632BA9FEEF941EA2" modified="2013-07-24" version="1">MKLLSIAIPCYNSQDYMRHAIETLLAGGEDVEILVVNDGSKDKTADIAAEYQQKYPTIVHAINKENGGHGDAVMTGLKNATGLYFKVVDSDDWVDEDCLKRVLAQLRAFTEQKEEIDMLICNYVYDKVGVKHKHVMQYRHAVPQNRVFDWNETRFKIGEYLLMHSVIYRTALLNKCGLNLPKHTFYVDELYVYQPLPMVKKMYYMDENLYHYFIGREDQSVQENVMIRRIDQALLVNRMLVTEVDLSKVTNKRKQAYMRRYLEIVTTVSSILLLKSGTAENKQKKDELWKFIREENPYVYKKLRHGLMGHVLHLPGKGGRRIALAGYKVTRKIYGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHP9</accession>
    <name>R7IHP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000161">
        <property type="protein sequence ID" value="CDE50122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50122">
        <property type="protein sequence ID" value="CDE50122"/>
        <property type="gene ID" value="BN770_02289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9337" checksum="27E702AE20D20F96" modified="2013-07-24" version="1">MPYVQTNMKASTLFDLALGVLRSGISDRLTRGESLLEQHHVPMDGTYSYLDVDGASVINMGSKSFPKNVRALHEFIYGEYIPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHW0</accession>
    <name>R7IHW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000189">
        <property type="protein sequence ID" value="CDE51056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51056">
        <property type="protein sequence ID" value="CDE51056"/>
        <property type="gene ID" value="BN770_00283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448291" evidence="2">
        <location>
            <begin position="33"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35994" checksum="3FED23A6428030FE" modified="2013-07-24" version="1">MKRKALSIVVLLLAVVLFGLLFVNHRQEQRQAAHMRQLQKEAMPYEQEINDIRSELAQKQRAINTKEDTSGILFGFVPASADDFAEIDKLAAEHSITPVILLDCSQEKEQLTRILKKAVAKDYEIVLAGLQFDESILQTADEMKDLLAQMDDAKSPAFLLRGNVNTEETRNLLKEHGYTELILYDASLQAGMQENGKPYICYGFFKQPVYYADYISQVVTAHTMMLASFDFSTIQNGTLQISDVERFMTLADDRKAANELRYVDLNSAFQAVADQNATQQERQESYEKYEAEQEKRIQELKEKISAIYSRWDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7II23</accession>
    <name>R7II23_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmd</name>
        <name evidence="6" type="ORF">BN770_00444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51444">
        <property type="protein sequence ID" value="CDE51444"/>
        <property type="gene ID" value="BN770_00444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="350" mass="39512" checksum="5FF2489762DC4D42" modified="2013-07-24" version="1">MAKKALITGITGQDGSYLAEFLLEKDYEVHGIVRRASISNTARIDHLIEKKAIHLHDGDLSDSSGLIRLVGEIKPDEIYNLAAQSHVQVSFDAPEYSGDVDALGVLRVLEAVRVCGLTKSCKVYQASTSELYGKVEEVPQRETTPFHPYSPYAVAKQYGFWMVKEYRDAYGMFAVNGILFNHESERRGENFVTRKITLAAGRIAEGMQDHLELGNMDSLRDWGYAKDYVECMWLIMQQEKPDDFVIATGVQHTVRDFTEKAFAANGISIRWEGKGIDEKGYDAATGKMLVCVNPQWFRPTDVDNLWGDPTKAKTMLGWNPQKTSYEQLVEIMAKHDRMLAKREKAMRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7II25</accession>
    <name>R7II25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000205">
        <property type="protein sequence ID" value="CDE51245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51245">
        <property type="protein sequence ID" value="CDE51245"/>
        <property type="gene ID" value="BN770_00343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448296" evidence="2">
        <location>
            <begin position="27"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="354" mass="38254" checksum="0708C96C2219CCA1" modified="2013-07-24" version="1">MTRKRFSAFLLASALLLVFLTNVVFADGGKKKQTILTSGDYQYVLHKDGSAELLYCLSDDAEIVIPDTLDGHRVTSIDTISFSLSLTAVTIPNSVVDLDHNPFGCCPLLQTISVTPEHPSFYTLDGVLFRKKDDALVAYPRGKAASSYTVPQGTSAVDERAFDSCSFLTSISLPASVTEIDDYAFSDCSALVEVSIPSSVDEIGSCAFNYCTALSSIVIPDSVTEIEEGAFAECRALTTVVLPNSLTEISDYLFSYCASLSSILIPDSVTEIETGAFQRCTALVSIVIPDSVTEIEDIAFSECSALRSVLLPASVTEIGVGAFDKCPNLTLTVFRNSYAERYAQRNHIPYTYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7II89</accession>
    <name>R7II89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51038">
        <property type="protein sequence ID" value="CDE51038"/>
        <property type="gene ID" value="BN770_00273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023162">
        <property type="entry name" value="Apc36109-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116922">
        <property type="entry name" value="SSF116922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="85" mass="9719" checksum="2E08E739E5368023" modified="2013-07-24" version="1">MADWRFQLVDRCLLDWDVMQLFPGAPQDEYEAEAYAIAARLPACRCESDVQQCLYEVFAAAFGELAPERDACKKTAERIWAEIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIE2</accession>
    <name>R7IIE2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulase (Glycosyl hydrolase family 5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50347">
        <property type="protein sequence ID" value="CDE50347"/>
        <property type="gene ID" value="BN770_00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436662" evidence="1">
        <location>
            <begin position="25"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="694" mass="74505" checksum="509BABE3DE341CFF" modified="2013-07-24" version="1">MNCTKKFLALLMVLAMALGMTAVAESPVASPVASPVASPVAGEVEPLSTAFLMYADANWHYQWWHDGSEPAEGMKVTEAAITGEGSYTVGLDFTGTPEGAASGIAFAAIGLENGEKALPGWTIRVDEIRVNGQPIEAKKGYTSSDDGIITRSNIYNEWVSELPADARSWDGVTEDANWITVDKAAFERVENVEVDFTLFRYGADMAYIMFADSSWTSQYWGTDDSAVKATNATVTGAGDYTVGLDFTATEAGAASGVAFTALGIKHGEKLFPGMSIKLNDIRINGESVAFTKGYTSSDDEVETRMNIMNEWVAEVPTDASVRSYDKDLTGVSPVIVDKAAFESVKTYEIDFTLVPKTDTAFLMFADSDWATSAWNPGEFAEGNAVTVDGPGTYTLSLDFSGVKGGEIPGVAFMAVGIANGEATFPGYFIDITEVKVNGEAIELGKDFTTTDDGIVTRSNIWNEWVTDIPAEARVADGDLEGVTAKIATAEALSGIKTIDVTFDYIYGVPPVVETEQPLTEDEVKELISKTYGAYIAVQSDPNYIFRNDWEEPSYGRDADNDVFTKLAKTNNDGTITDYGATFEDAVISGNGTYTCSMTTGEMGFGEDTAFHFFRVSTDIPSKLVKEGYVTISDVTIKIGEGKTQSGVVVDTSGDWVKLIVEDNYNNIKADGVVLTVPAPNTTTVFTFTVSGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIL2</accession>
    <name>R7IIL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51624">
        <property type="protein sequence ID" value="CDE51624"/>
        <property type="gene ID" value="BN770_00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="64"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="756" mass="83830" checksum="81E5C4F48B18FD2A" modified="2013-07-24" version="1">MNVDQLAESLRSDPMFMQNVVRWDVLPARPAVYEPFPDSLDPRLLPVLEKRGVHQLYRHQAHAIREVLAGRDVVVVTPTASGKTMCYNLPVLSAILQNDDARALYLFPTKALSADQVSELYELIEAMGVDIKTYTYDGDTPGAARKAVRQAGHIVVTNPDMLHSGILPHHTKWVKLFENLRYIVIDEIHTYRGVFGSNLANVLRRLLRLCDFYGSHPQFILCSATIANPKELAETLTGREVSLVDDNGAPMGVRHFVFYNPPVVNRQLGIRKGVLQETRRIAGLLLQNGIQAITFARSRLAVEVLTKYLKDMVRDPLGNAGRVRGYRGGYLPTERREIERGLRAGRVDAVVSTNALELGIDIGALDACVLCGYPGTIASAWQQAGRAGRRKGTSIVFYVASSAALDQYIVSHPDYLMKRSPENALLNPDNLYILLNHFKCAAFELPFEDGEGLGNAPGAPELLEYLDEAGILRHVGGRYHWSAEDFPASEISLRSARAEENFVIIDTTDPANHRVIGEMDRYTVPMLLHENAIYMHEAQQYQVEKLDFDACKAFIRRVDVGYYTDANLNVTLSLLDKEKEEEQDGGLTALGEIRVSTLVTMFKKIRLDTHETLGFGHVRLPETEMHTTAMWWTLPDALAARFESDTLKNGMMGVANLLRIVAPLSLMCAPQDIAIVYQVKSPLTDKPTLLLYDNIPGGIGLAQKAYAMRKLLLEQALQVVRDCACRQGCPGCVGPVGEIGEDGKATAIALLEALTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIX6</accession>
    <name>R7IIX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51590">
        <property type="protein sequence ID" value="CDE51590"/>
        <property type="gene ID" value="BN770_00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448013" evidence="6">
        <location>
            <begin position="42"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="7">
        <location>
            <begin position="94"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="7">
        <location>
            <begin position="214"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="7">
        <location>
            <begin position="330"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="7">
        <location>
            <begin position="422"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="501" mass="50819" checksum="3CFBA371FDE64339" modified="2013-07-24" version="1">MSETKTTRKQLPAYLILALIALAAALLLAVTNAITAGPIKAHEEAAQNAAFQSVMTADSFSTMSIPDGCNVTSLVEAKKDGKTIGYCAVSSAKGYGGNVAVTLGVDMDGKIVGCQIGDTNFAETDGFGARWKEPARAEAFIGLSAFGGDTIEAITGATVTSKAVLAASNDVLKCISHVLGKDVEGDVLAFGVKEEKPAQTVELTGDVHQGKAVGFGNGEVTARLTLNDDGTIAALVIDASTQTPGFGTRCADEEFTAQFIGKSGPFTLNENVDGLTGATITSTAAVEAINAALTSPAMAAEDLEPVATEAPAATEAPMVLENAKTATIAGFGGADITVQVTDENGVITALVVDASSQTAGLGQKCADEAFTSQFIGKSAPLTLGEGIDAVASATITSQAVVDAVNSLYAEAPAKVLTTKVKGWHEGVAVTVEIDKNHVITALTVDASGEFYALGGKCADEAFTSQFIGKSAPLTLGVDIDAVTGATLTSQAVVDAVNQLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ44</accession>
    <name>R7IJ44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51506">
        <property type="protein sequence ID" value="CDE51506"/>
        <property type="gene ID" value="BN770_00463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025542">
        <property type="entry name" value="YacH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38430">
        <property type="entry name" value="PTHR38430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015034">
        <property type="entry name" value="YacH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="172" mass="19487" checksum="BC16E4DC76728389" modified="2013-07-24" version="1">MLCEECHQNEAVYTISVMMGEAMTQRHLCADCMAKMNMNIASGNMQKLLGAILNAINRGEQPEEGEKVPDDQPDITCPRCRMTLSKFIKTGRLGCPDCYQAFAAQLHPMLLQIHGRVQHAGRKPLQSETDQRSRYEQEELTRQLQLAVNAEDYEHAAEIRDRLRALLGKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ93</accession>
    <name>R7IJ93_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51368">
        <property type="protein sequence ID" value="CDE51368"/>
        <property type="gene ID" value="BN770_00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="178" mass="19266" checksum="62BC1E2D36C46EFF" modified="2013-07-24" version="1">MPNPLTARRSIRKFQPTPVSPDTIRAIVAVAAYAPSWKNSQTTRYTLLTKREEIDRVADECTMGFQKNIDTLHGAPALVVLTTVNDRSGYERDGSFCTSKGTHWQSFDAGLAAEAFCVAAHDAGLGTVILGIYDEGKVKAVLNLPETESVSALIPIGVPAESPAAPKRKDVSELLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJA6</accession>
    <name>R7IJA6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51705">
        <property type="protein sequence ID" value="CDE51705"/>
        <property type="gene ID" value="BN770_00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="3"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="462" mass="50919" checksum="CF8CD24F31EABEC6" modified="2013-07-24" version="1">MTPDAPHADIAALFAAQKACFASGITRPVPHRLDQLRRLRRAIQAHDRDIEAALQSDLGKCRTEAYMCEIGMVLSELGYLLRRTRRYCRDTHVLTPLAQFPARSFIRHDPMGVVLIMSPWNYPFLLTIEPLLGALAGGNCCILKPSKDAPATSAIIRQICAECFPLDEVAIVEGGRMENQALLDQPFDKIFFTGSSHVGQEVLRRAAEHLTPATLELGGKSPVIVAKDADLTLAARRIAFGKLLNAGQTCVAPDYVLVAREVEDAFVAALQKQFDQLCPDPLHSAEYVHIVNQKHFDRLTGLMASGQIVYGGSIDPAALRIAPTILRNVSPDSPVMQEEIFGPILPILPVSSIDEAIAFAAARPHPLACYLFTKDRAVQRRVLDTLPFGGGCINDTIIHLATSRMPFGGVGHSGMGGYHGRDSFRCFTHDKSIVKKALWLDLPMRYTPYSKKKETLIRFFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJI3</accession>
    <name>R7IJI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacterial extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51646">
        <property type="protein sequence ID" value="CDE51646"/>
        <property type="gene ID" value="BN770_00548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="966" mass="107641" checksum="F711C0004AF0CB88" modified="2013-07-24" version="1">MERSFGSKYGKWIALTAVVLALVLWFVLSGGVENYRAKYEGYDLSQQIGDIGRSSTYSLYLRAHEGAPDASSDVSIPLVTVDSDGVTAQKDGLLMQSGSSATFAVTVPETGFYNIRLTYRTEAARGVDLERELRINGEVPFDGADTLTFTRLWHDGGEVRQDSQGNDIRPTQVEVFGEQNACCRDSMGYITEPYRFYFEAGESTVTLIATSEPMLLTALSLTAPEKMPDYAAYAAAQPQENSVPADFALVLEGESSTLRSSPSLYARYDRSSPATSPCDVRRTVLNYIGGDAWRDAGQWIEWDFDVPENGWYNITIKGRQTYNRGSVSSRILYLDGKIPFSGMENVSFPYTTAWEMNTLSDDSGTPYRFYLSAGHHTLRLEATLGDMGQILSDMEESIYRLNQMYRRVLVLTGVNPDRYRDYHLEQVYPEVIEAMAQESRLLYKLVDETVAITGQKSDRIAVAQTLAVQLESFVEDPAKITEAFTNFKDNITSLGTSMQNMRQVKLDIDLIAITADSVTVPQPSENFLDRALHELKSCVTSYFVDYNALGDVYDASEDVLEVWILTGRDQSTVLKTMVDDTFTPSTGIPVNVMLVDPNALLNAVVAGNGPDVVISTDSWNPVNYALRHAVEDLTQFDDLQEVLDQFYPSAYAAFSFNGGLYALPETQLCSILFYRSDILEEYGLSVPETWDDLIAMLPTIQGANMSVGIPYPDIAAPNLSSYYAMLYQLGGALYNDSATHTTINSEAGVQAFERYTSLYNDYGLPTIFDFVSRFRSGEMPLGIFDYTTFNTLTVSAPEIRGLWDIAILPGTSRTAEDGSTYVDHSGHSQGACCMMIATDSETTKQNAWQFMKWWTSTDAQVRFGREIEAVLGSSARYATANIAAIEQLSWSEAQLKVIREQMTWAVGFREVAGGYYTTRHMTNAVRKVTNDKTDPRETLLDYARTINEEINKKRLEFGLPIDVETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJT8</accession>
    <name>R7IJT8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000180">
        <property type="protein sequence ID" value="CDE50852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50852">
        <property type="protein sequence ID" value="CDE50852"/>
        <property type="gene ID" value="BN770_00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF539">
        <property type="entry name" value="PTHR24031:SF539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="671" mass="75233" checksum="445BFEFF5B38C354" modified="2013-07-24" version="1">MALVSAVTNAASLHDLGKLEEENQAALHAGNQPHLPINHTDAGTALLLHENKMYSAVCVMSHHRGLPDFPKECCHGSEAFRDTDIASATDSKLPELKAIHLDLFGEKTADEQPAAGCRSVFMRLALSCLADADHEDTARHYGQEPMDGQQNELRPAERLQVLNAYVSGLRAEDERSRLRAQMYQCCRDSKVNDHVVACDSPVGSGKTTAVMAYMLSQAKKHHLRRIFVVLPFTSIISQSVETYRRCLVLPGEEPNKIVAEVHHRVDFESESVRHLSTLWKAPVIVTTAVAFFETLASNRPSALRRLHELPGSAIFVDEAHAALPSHLLPVAWKWINCFADEWNCHWVLASGSLNRFWTIQQIAAAGTRRVPDLVDNALRSALAQYEQNRIRYLWNPALMTSEALAQWVNSFPGPRLLIVNTVQSATVIAKTIMQLYGRNRVEHLSTALTARDRARTLARVRQRLRNPSDCDWTLVATSCVEAGVDFSFSVGFRETASLSSLLQASGRVNRNGKTKNALMWSFGLNYADDALLKEHPIIKHAATVLTKEFLEKDRPILPTSVTDSIRLELARYGEHQTNLLKDEDSLSFVKVEDTFRVIDNHSVSALVHAAPDEDTRIHEISREQVQMDTVQIPQYRIKDWNVQPIRDELYQWTLAYDGFLGYMAGVLSIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJU4</accession>
    <name>R7IJU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51890">
        <property type="protein sequence ID" value="CDE51890"/>
        <property type="gene ID" value="BN770_00673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="6"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="335"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="734" mass="82742" checksum="7BC34E1A07911761" modified="2013-07-24" version="1">MAKLEVRNLTISFRTNNGAVRAVRDISFNLEEGETLAIAGESGSGKSVTTRAIMGILAGNAMVDAGEIIYDGKDLLKIPEEEFHTLRGHKLAMVFQDPLSALNPIMRIGKQLTEAMLLNNKERRRDGKERFNSLLAQLEKTMVADAEARGQGAQAREAIHAKTKQFDHFASVGLKMEYTYKEAMESIVECMDGMDEIDNAILTSKDKDVREICGRIRKSLKHIFDPYTFDENDPEIAKWHTALEGFQKNYTRRRESEMRALMADMTAKLGAMVNAQEPNFFCIGYLAASGKTPDPKKQSITELNQMARETLDREFMIDFLQDIAHALQYSSQQAAKSQQAAVDALRSALKVYQQKPLNEGECKEALHKSAAAVEAAIDKLQLDKDNQAYVYRSGAQSYIDRYARSKTHNPKEEKRYAREQKKFEAQKAKGKNPPSVIPKNLIDADMAQHNLCEMTQSLLKHFEELIAASETKDFDVLAVEMVDYMKARAQDYAFKLTKGMARHRAIELMKEVGIPEPHKRFYQYPFEFSGGMRQRIVIAIALSANPDILICDEPTTALDVTIQAQILELINRLKKERRLSVIFITHDLGVVANMADRIAIMYAGKIVEYGTADDVFYDPRHPYTWALLSSMPDLETREKLEAIPGTPPDMILPPKGDAFAARNKYAMEIDFEEQPPMFHVSETHMAATWLLHPNAPKVNPPAIVVERIERMKKEQAEREAAEALQNAKKGAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK76</accession>
    <name>R7IK76_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51866">
        <property type="protein sequence ID" value="CDE51866"/>
        <property type="gene ID" value="BN770_00661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="229"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="415" mass="47258" checksum="8B4BD28CBB3D222B" modified="2013-07-24" version="1">MKVMWMGNIILPAIAEKESLPPVYIVGWLVGLSRRLTQLPDVALTYVFDAPKALTGEVDGYRYYGLVNPTRPTQRCGEAYTRQLEEILRKEQPDVIHLWGTENQHTLAMVDAAEHLGMRERIVISIQGLLSIYAEHYRAYLPEHVCHGHTLKDLVKGNIVRQEAIYRRVGQYEQEALRRVQHVIGRTDWDAACMAELAPQAAYHFNNETLRDEFYTGEWSLDSCEPHSIFCSQAHVPLKGLHLLLQALAIVRKRYPDVKLYVGRKDYGRIPPPARNAYERYIHRLLRENDLYDHVVFTGSLNAQQMKERYLKSQVFVLPSSIENSPNSLGEAMLLGVPCIASDVGGVRCLMTHGVEGLIYPADDPHLLAYDICEMFAHPEKAAQMARAGREHAGKTHDAQKNLEILHQIYTEIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKA7</accession>
    <name>R7IKA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BH1295 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51906">
        <property type="protein sequence ID" value="CDE51906"/>
        <property type="gene ID" value="BN770_00687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435981" evidence="2">
        <location>
            <begin position="30"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="110"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="898" mass="94527" checksum="366A32742EDD3355" modified="2013-07-24" version="1">MTKSTTRRFLCCLLALCCLLGSLTAFSLAAGTSYPYSASVNADTNLRRSPSSAESNIIARIPKGTILTVTGASGNFLCVTYDGQVGYIFKQYAEQVTTNTSESGSVAYGFPYYTTTKSSVNLRTTRSTTSARVTTIPKGATVIIHGVSGDWAQVTYQEKTGYCMTAYLKLLTVVEPTAAPTAVPTSAPILEDSTYKVLQNGSTGNQVLALQQALAELGYLTSTPDGTYSTTTTQAVIALQKMNGLPMNGIADANLQALIFHGQPKNSSGTKVSIKTLPALSGITIRLHDQGVLVSTVQTRLTQLGYYDGEISGVYDVATQAAVKAFQKANGLKADGACGTATQEKLMSAAAAPGTLPTMEVTVTATPAPTDLPPLTTPAATVRKGSTGNDARLVQQRLIDLGYLSGVADSIFGTASVNALKEFQAKNGLSADGIAGASTYQVLFSYLAISADYIVTPAPTATPLATATPTPAPITKDNVVTIRQGTSGDAVLRLQERLTALGYYNSRRDGVCMADDAAAIRAFQRMNGLSVDGVAGYDTQVLLYSATAIGSDGIMAGASVDVSVTLRRGMTGEAVRALQQRLITLGYLSDTADGIYGTATAEAVYNFQKRNGLTRDGVAGNKTLIALYSASAATPTPAPTIAPMNTPSAASVIASASALHRGDNGTAVKAMQQRLIDLGYLTSGSADGIFGVKTYQALRDFQLANALYVDGVAGKNTIASLNSSSATGKNTARPNTTATPTPNISNDIGTTTKVSAENVVYEYWYSTVRSACRQYPYATVYDYSTGISWQVHMFSYGKHAEAEPLTAADTAKLEQAFGGNTWTPKAVWVIFADGTVRMATTHSMPHEVQHITDNNFPGHLCIHFPRTQAQVTAIGPYAMSHQQTVEKGWAETQAMIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILE4</accession>
    <name>R7ILE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface antigen BspA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51447">
        <property type="protein sequence ID" value="CDE51447"/>
        <property type="gene ID" value="BN770_00447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="252" mass="27876" checksum="0F6303E50EB4987A" modified="2013-07-24" version="1">MSNVTSIGEKAFSYCGTLETVVSLESITSLGKNAFEECRSLVTVGKIGNLTRLPNEVFRECKALANVTLPDTMETIGTAAFKHCYGLPEIVIPDSVTTIEEEAFSGCTSLQEIIVPDSVVKMGNHVFGGCRSATRIVFPKYLTYLPGSGVSFCNYMVEFVFPENVKSISNYFFYGCISLKEIVIPDTVTTIDFRAFWDCTSLTRITIPASVTKIDSTAFDGCKKDKLVWVVTPGSYAETYAKKNYYHYVYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILS8</accession>
    <name>R7ILS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51587">
        <property type="protein sequence ID" value="CDE51587"/>
        <property type="gene ID" value="BN770_00502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="181" mass="20384" checksum="7891EEC6F0EE91AF" modified="2013-07-24" version="1">MAKELKGTKTEQNLLEAFAGESMARNKYTYFASKARKDGYVQIAELFEATAANEKEHAKMWFKLLEGGEIKDTAANLLHAAEGENAEWTDMYVRMAEEADAEGFPAIAHKFRMVAAIEKAHEERYRRLLANVENDLVFSKDGDVIWECANCGHIVVGKKAPEICPVCAHPQSYFMVKAENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILU1</accession>
    <name>R7ILU1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51602">
        <property type="protein sequence ID" value="CDE51602"/>
        <property type="gene ID" value="BN770_00517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436035" evidence="4">
        <location>
            <begin position="23"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="588" mass="61731" checksum="B87111BFA017BBCE" modified="2013-07-24" version="1">MRKFLSLLLALVMVLCCIPAMAETADGVYEGTGAGLNGQIKVSVTVSGGKITEVKVLEHSETAGISDPAIEKIPAAIVEAQSADVDIVSGATFTSKGIIEAVKNALNPDAAEEAGMPFEQPDILVIGAGMAGLATAARAAELGLNVLVVDQAATYGGSANVAGGTLLGTCTRMQKEAGIEDDPDLCFADFVRLGGAGNFNEEIAREFAEISGEAVDWLDDLGTDFGDRVPYFGVYQPLNVARNYSGKGGARAFVVSLYAELEKYFSTNAYMMLNTYVTGLVTNDEGAVIGAKARLADGTETTLLAPATVICTGGYAGNEELLNKYNFENVLSTSPACVTGDGYAWLEELGAPLTNMDFCTAYAGGIPTSDDFRSFGYFNATNGALWINTNGERMADETGADSHVKSETWANAPHNIVYTVFSSEMLIPDAKVFSTGAWGSVKEEFDPYVESLIEKGLAWKADTIEELAEKVGLPVDAFKATIAAYNDGCANGNDPFGRTKQEVAMANGPFYAVKTVPYVMITCGGPMMTKNCEVLNSDGLVIEGVYMAGEIVGMANVGGRNSIGGMGHGNCLVWGKKAAEVIAAKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILW0</accession>
    <name>R7ILW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51622">
        <property type="protein sequence ID" value="CDE51622"/>
        <property type="gene ID" value="BN770_00525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="278" mass="31422" checksum="8448DDE07F5D6295" modified="2013-07-24" version="1">MGFMATIKAQQAMRAHGKGDLEQAKKLYEEAIDKGLMSARPMLGYAILLIREGSYDKAMPLLIKAQKCPDLTPDQKSQLFVDYAACLMKKGELDKAIHLLEKQHNRAPIGLTYQTLGYMYVEKYSGAKPVAEAAPEKAAEALEMPDTEASTEAAEEQPKAKTQEDIDREWQEGIDKMFAFIQESVDYDDEDPVCLDNLGQAYYRVTGEKDKAKEWFEKAHAEKDSQIDTLWFLSRYDLEAGDKAAAIAKLEKALDGRFSPLNFCTKDMVREEVERLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMM5</accession>
    <name>R7IMM5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51877">
        <property type="protein sequence ID" value="CDE51877"/>
        <property type="gene ID" value="BN770_00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="83" mass="9133" checksum="2D7B517819BFE459" modified="2013-07-24" version="1">MIKTTLKIDGMMCGMCESHVNDAIRKAFPAVKKVTSSHGKGETVVISEDPLDEAQVKAAIAATGYDFKGMSSEPYQKKRFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMU4</accession>
    <name>R7IMU4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51952">
        <property type="protein sequence ID" value="CDE51952"/>
        <property type="gene ID" value="BN770_00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="4"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="285"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="653"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="765" mass="86576" checksum="7DFD5785BEBBC18C" modified="2013-07-24" version="1">MDLSMLNPQQRLAAETLEGPVLILAGAGSGKTRALTCRVANLMAHGVAAYHILALTFTNKAAKEMKERIAALVGDQANDAWISTFHSTCAKILRRDIEKLGGYTRSFVIYDDDDQGAVLKEILKRQNIDDKLLPIRELKAKISDAKNKLMSPDEWFDHSDRDFRCQQIHTVFVEYEARLKTLNALDFDDLLVKTLELLADHPPVLDVYRKRFQYVMVDEYQDTNYAQYMLVKLLTDQSRNLCVVGDDDQSIYGWRGADIRNILDFEKDYPDATVIKLEQNYRSTANILDAANQVIAHNSGRKEKKLWTEQGEGDPIRLFDAGDEREEAAWVADRIRQLNRHGEPYGNMAILYRTNAQSRVLEEMLMRSAIPYKVFGGQKFYDRKEVRDVIAYLRVVVNPADDVSLRRIINVPKRAIGDSTVQELMNHAQQNNMPLYSALSDVPDSLSARPKKCVSDFFMLMTMLLALKETMPLEEFVSTLVEKTGLLAQYQKEDTEEARSRVENIQEFMGAVSEYAKATENATLEDYLENVSLVTDLDQQEDERGYVTLMTLHSAKGLEFPDVFMTGLEEGIFPSARSLMDETKMEEERRLCYVGITRAQKRLFISRANQRMLYNQVNHNAPSRFLAEIPERLLSDEMAGMKERFGDRVQPQMRSRSAYNRGGTNRPAPSGSAPIRPGSGNTGLRGLNIPGVQKGFVQSPARNMATSAMQNLYRPGDRVRHLKFGEGTVVEVTGSGSMSRIKIEFTAYGTKEFALATAPIVKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMY3</accession>
    <name>R7IMY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000253">
        <property type="protein sequence ID" value="CDE51992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51992">
        <property type="protein sequence ID" value="CDE51992"/>
        <property type="gene ID" value="BN770_00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="122" mass="13539" checksum="D3BE6EB8CCDCE94C" modified="2013-07-24" version="1">MNFTNYEEMAAMILFGIGFTTLLLHKNMIKKIIGFSMMDSAIYLFLAVKGYIAGRKAPIVVDGITSMEAYINPIPAGLVLTGIVVSVSVTALMLALTVRLYRQYHTLDIDEITALCRKEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3E3</accession>
    <name>R7I3E3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000003">
        <property type="protein sequence ID" value="CDE46160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46160">
        <property type="protein sequence ID" value="CDE46160"/>
        <property type="gene ID" value="BN770_00756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="501" mass="56740" checksum="FC88F4EB25986862" modified="2013-07-24" version="1">MASESIKCAPAGMSIQRAANLPESRGGALWSVFRGEAFDPQGGAPTDKSDAVRHFVVGSLCRNQRGSVAALPTASKEVHTSKIRATRHNGRAGKNGVFTAKHNDRNFDVTHAEHIDPAKTHENVYWDWLNGMRTGERSADVPSFEEVERIFYERHYSDYVAGQCARNAERRHTERNRTVEQIRRDKRTCPEETIFQFGKEGIGATPEQLLDIFTAFKQQFEERYGKHVHMLDWAMHCDETTVHIQERHCFDYVNKYGEVEPKQEKALALMGIPLPQPDKPPGRYNNRKITFDAMNRLMLIEIAKAHGLDIEEQVKYGGKNHLEKLDYIIAKQLETIRNQQKQLTAQAQQIQTLTAQIAEKDAELDTKLFRLSDVDLLIEQVTDICYEKAVTAVSESMSQTALDKAAAGVDRTIREAKSPGSRLGVPFISIVETWLGKAREDVFSALLSMADDVRRRLLLPAMNEIMKCSIAETARPAVVEKLRPKLRDDAYPKKRPDAWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3J4</accession>
    <name>R7I3J4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46474">
        <property type="protein sequence ID" value="CDE46474"/>
        <property type="gene ID" value="BN770_00886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="125" mass="13489" checksum="A4244E3BD6B186F2" modified="2013-07-24" version="1">MSTSAIDRKCVKLALYDLLFAAVTALGGFVYEQFSHGVYSDFMVYAFLPLLVLGACPLLIRALRGKALPGRWCVRLYHWGIIALTVGCLFQGALEIYGTTSRLVMGYWIAGGACFAGSLVAGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3S8</accession>
    <name>R7I3S8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46260">
        <property type="protein sequence ID" value="CDE46260"/>
        <property type="gene ID" value="BN770_00809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436127" evidence="1">
        <location>
            <begin position="24"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="241" mass="27000" checksum="CBEAD83BE6744026" modified="2013-07-24" version="1">MKKFLAFLLSLTMVFAMAAVAFAEGETYLWDNFDDRDPNAKPELAPNGVHLWWDNWANLRAKNEDGALKLDMRPKAYDPEDYDSEDDYYAHAADWMANWGEAVDMWGLDGVSYCKYLTIRIKGAEGGEENKLIMDWHPEDAKFYAARFSDLVLADGTHPVITTEWQDLVIDLEASGFPGMTNALHIRAFAKCVIYLDEITFSEAVAPIDATSSETIQAGLTAPETGKPGDLPIKDYLAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3V2</accession>
    <name>R7I3V2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein transpeptidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46579">
        <property type="protein sequence ID" value="CDE46579"/>
        <property type="gene ID" value="BN770_00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="164"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="474" mass="51004" checksum="82ADD304AB470408" modified="2013-07-24" version="1">MKRQRFKFKLLAFFLFALFALLGTYGMHSIALYGNRWFTYAKNPRVRAQKQNVVPGDILDRSGVVLATSSVSEDGTVTRVYQSDEAARRAVVHLLGDSDGQVANGVESFQTAYLYGFQTGIWERIQALVTGQKRHGDNVTLTVDSSLCTTILQSFQRRAPGKSGAAVVMNYKTGEVLGMVSLPTFDPMSSSAVSASSNAYWNRVTQNPYTPGSTFKLVTAAAQLRVNPSAQTMQVNCTGNLTVDGQVIHDYGSASHGAIDLKTAFMRSCNNAFAQYALSMGDKALRETAESFGFNDNFLFRDLVVENSVYPTTGRSNFNIAMSGFGQSAITATPMHLCLLAAAVANKGVMMEPVLIDRVASPSGVTRYTRSSRVYRTVMTEGQAAILAEYMRAVVTSGTGTRAAVSGMIICGKTGSAETSLNGRAITNGLFIGFAQDVPYALCVVVEDIDDGQGGGSTAAPIARDIFAYLKNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3W7</accession>
    <name>R7I3W7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000007">
        <property type="protein sequence ID" value="CDE46310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46310">
        <property type="protein sequence ID" value="CDE46310"/>
        <property type="gene ID" value="BN770_00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="296"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="630" mass="70189" checksum="0DD2BF093C1DFF93" modified="2013-07-24" version="1">MKKKSVFANQTMRIGLLMLLDALLISASLLMGLQVYYDMHAPAAHILHVWRSLPLLIVSTVALLHMMGFYRGILKYAGVDLLLQIACGTLGGTGITYLVSFLCYSIRREPNIFLMPRPVYLVQWLLLMVMLAASRFVIKVAQGGGWTHFFTGGSAKARRVMVVGGGWGGAQVIRDMQAGRYGDCVPVIVVDDDESRRNTRIGRVRVVMDTGKIADYVKQYAIDDIIIAIATPKSDLTELMHTCVDTGCHVRRYTVMQEMNGGQGQMRDINIADLLGRDEKHLDMSEVEQVIAGRRVLVTGGGGSIGSEMCRQMMAFIPEKLVLYDISENYMYDLFAELKNKYGEIVKNTVVLRVGSIRDEATLNQVFDEFKPEIVIHAAAHKHVPLMEDSPEQAVRNNVFGTYNVAKCAKEHGAKRFVMISTDKAVNPTNVMGASKRMAEIIIEAMQKQSSTTQFTAVRFGNVLGSNGSVVPLFERQIRAGGPVTLTHPDIIRYFMTIPEAASLVLQAASIARGGELFVLDMGKPVKIRELAERMIQLYSDPLKPPVEIVYTGLRPGEKLYEELLRDEETDTATSKEKIFIAKPEQVEWADVENMLRTLHECLDNHGDIKACMHKLLPSFKTPEEVNGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3Z6</accession>
    <name>R7I3Z6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46350">
        <property type="protein sequence ID" value="CDE46350"/>
        <property type="gene ID" value="BN770_00832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="143" mass="16132" checksum="E14D2D5D124D59C9" modified="2013-07-24" version="1">MAAVVGIVLPMLPKAQAQIELSYPPENAYMMKEDDGFVGWMIHFYSTNVSDVPFTPTYAQAKWYEGDKLIGSVPAIDYEYMRKWMESDALVKGEMPLDLYCGTDRLNVDRGVFIISGTDANGHELKFSISIDLIHEFPPESEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4L8</accession>
    <name>R7I4L8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mprF</name>
        <name evidence="7" type="ORF">BN770_01025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LPG synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46799">
        <property type="protein sequence ID" value="CDE46799"/>
        <property type="gene ID" value="BN770_01025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="354" mass="39586" checksum="36B4D4EC4A8B23ED" modified="2013-07-24" version="1">MKKKKWGRILSIGFILLSMLIVVLIAFNNPELMNAWDVLFTLDKRWLLLCLLAMVGYVYAEGAGLCTFLRMEGYKVSLNTATHFSFAGIYYANVTPGSSGGQPMQIYLMSQRSIPAGVATSALTARYFFNQLTLVVMTLLLWLSNRAYVAEHLGNVIPLIILGCVVNSFCVPSILLVTFHRSWVEKIVQWGIRFLTKIHICKKPEQWQASAETTIEHFHGSLMDLVHHPMHLLAQLVISVVEMSCLMVVPLLVYRAMGLTGTPWYHVLTVSFLLFVSASYTPLPGASGAQEGGFLVYFGSVFTGGTVSVALLVWRFITYYLCLIVGCADSIFTSLRKRVKPIRHEKKGQTKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4N6</accession>
    <name>R7I4N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46446">
        <property type="protein sequence ID" value="CDE46446"/>
        <property type="gene ID" value="BN770_00864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="343" mass="38903" checksum="EB6C5ABBEB1DEC65" modified="2013-07-24" version="1">MSEIKIINGQSLPNIPWQERPADLEEGAVLWRYTENPVMGRNPTPKIGRIFNSAVVPWQDGYIAVLRGEQVNGVPHVYLGRSKDGIHWNVDRERVQFVDENGEPWMPNYAYDPRLVKVEDTYYIIWCTDFHGAAIGMAKTKDFKHFTRMENPFIPYNRNAVLLPRKIGGMYKMLSRPSDSAHTPFGDIFLSESPDLIYWGRHRHVMSRGPMWWEAVKIGAGACPIETTEGWLMFFHGVASTCNGFVYSMGGAILDRDEPSKVLYRCENYLLTPEMPYEVSGFVPNVVFPCATVQDADTGRIAIYYGSADTCVGLAFGYVDEIVQYIKDNSVLNPDDGVAFEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4R5</accession>
    <name>R7I4R5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46481">
        <property type="protein sequence ID" value="CDE46481"/>
        <property type="gene ID" value="BN770_00893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="463" mass="49807" checksum="CF5AB4326F8510ED" modified="2013-07-24" version="1">MAMSAEERQQMLLTQPVEKIIPKMALPTICSMLITSIYNMADTYFVSQIGTAEATASGTSASAAVGIVFSVMAMIQALAFMFGMGSGTNVSHLLGMGKRKEAEVYSAVGFFSAVAAGVLIAVLGNVFNEPLMRLLGATETAMPYALDYARYIFLAAPFMMGSLSMNNLLRFQGLATYGMVGIISGGLLNMLLDPLLIFVFDMGIAGASIATAISQLTSFVILLVMCSTHADAITIHPRNYRPTKQMYAKILNNGLPSLGRQGIMSVSTSLLNNAAAVYGDPAIAAFAIVSRCLNFVNSTVVGFGQGFQPVCGFNYGARKYDRMHRAFSFSVKVTTIVLLVLGAAGFAFAEPVVTLFRRSDPEVIRIGTETFRVQILTVWAWGFITLSNMYTQAIGYGIRSTILAAARQGLFLIPTLLVLPNVWGLRGLEVCQPLADVLTLALAVWMMTKVIRAQKAQMAQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5C8</accession>
    <name>R7I5C8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prevent-host-death family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46463">
        <property type="protein sequence ID" value="CDE46463"/>
        <property type="gene ID" value="BN770_00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="89" mass="9777" checksum="BBCAF9AAEAF1191F" modified="2013-07-24" version="1">MTNIVPISDLKNYTEVLSHCDNGSTVYLTKNGRGKYVVQSLAEHEKLQATVKLLAELAKGVESIRTEGLLTIDEAFAGLDEEKQDPKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5T6</accession>
    <name>R7I5T6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47010">
        <property type="protein sequence ID" value="CDE47010"/>
        <property type="gene ID" value="BN770_01106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="502" mass="56895" checksum="243C7845574B4456" modified="2013-07-24" version="1">MKQDSIRIAADSQAKFNNNTAFCIGTGRMGLALQQEYQQQLAMAQAECAFTHIRGHGLFSDDMAIYQPYQDAEGNWHEGYNFTYLDRVMDDYRAQGLKPFLELGFMPEKMASGTQTIFYWKGNVTPPQDDAKWTAMVQATLAHLAERYGKDEVSTWPCEVWNEPNLTGFWENADEEKYHHLYAVTAKAVKEVLPDMRVGGPAICGGATSQDWVRNFLRFCEENQLPLDFVSRHAYMGETPEHRGRYLYHTMRTVDSLLAEMQETRDIIDSFPEYRGMEMHITEFNTSYNPFCPIHDTNLNAAYMAGVLARMGDVAASYSYWTFGDVFEEQGVPPMPFHGGFGLIANGQIAKPTLWSFAFFSHLHGTPVHRDEHSVIVHKDDGSYEGVLWNLCRTDRDELTVTIALPAGGEQTLTTETVDEVTCNPLKVWHDLGEPRSLTANQLRLLRQAGQPAADTAVLAAENGECTLQMTLRQNAVVRFTLSARNQQGDYGYDYTWYQQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5V0</accession>
    <name>R7I5V0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ion-translocating oxidoreductase complex subunit C</fullName>
            <ecNumber evidence="9">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Rnf electron transport complex subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnfC</name>
        <name evidence="11" type="ORF">BN770_01119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47025">
        <property type="protein sequence ID" value="CDE47025"/>
        <property type="gene ID" value="BN770_01119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00461">
        <property type="entry name" value="RsxC_RnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01945">
        <property type="entry name" value="rnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="458" mass="48414" checksum="21F78097336CAAE2" modified="2013-07-24" version="1">MFPGGTHPHEGVNGKAVNSGNAIRELPAPARVVIPLSQHIGAPCKPIVQKGDLVLAGQKIGEAGGFVSAPVHSSVSGKVVGIEPVELANGSTVSAVVIENDFQNNWVELHPAEHPETLTAQELQTIVREAGIVGMGGATFPTQVKITPPKGKTIEKLVINGAECEPYLTADHRLMLEKPAEIIDGIHLMMLALDVKEAHVGVENNKMDAVEALRAAAKNVEGITIHDLPVRYPQGGEKQLVYALTRRKVPTGGLPLDVGCVVSNVGTVYAIQQAIREGRPLVQRVTTVGGLVNNPGNFLVSVGTPIDTLLEACGGMQSGARMLISGGPMMGMAITRTDIPVTKGTSGVLVLGEEAVDPVESACINCGRCLRACPMQLMPTLLDRCVRADRYDEAEKYGIMNCIECGACTFVCPAKRLLTQSCRQGKKVITTRKKAEAAKKAAAEAAKKAAEEQSKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5V7</accession>
    <name>R7I5V7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="2">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47035">
        <property type="protein sequence ID" value="CDE47035"/>
        <property type="gene ID" value="BN770_01124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="PTHR34983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005145702" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="398" mass="43820" checksum="BB2724980D7E3304" modified="2013-07-24" version="1">MKRLLACLLSATLLLPHLALAEDDAFPASFHFGADVSTVLSEENSGVVYRNRDGEPTDLFVLLKEAGWDTVRVRVWNNPFDEDGRGYGGGNCGVANAVEIARRCKEAGLSLIVDFHYSDFWADPAKQMSPKKWVTMDLTQKCSALYAFTTDALTQIAATGVDIWMVQVGNEINGGMAGEWSTNGRNQLMNAGSAAVRATLPDALVAVHFTNVSQSDAKKYIREVCEGDTPVDFDVMAYSYYSYWHGSLENLSELMADVRENFGKDVFIAETAYPFTTNNLDTHPNSVPNEWCDMKQDISRDGQAADFRETVETAVQAGALGVCYWEPAWIPVPGNSWEEQSKLWEQFGSGWASSYAGGYDPQDAGAWFGGCAWENQALFEVDGTPAWTLSLPNILRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I620</accession>
    <name>R7I620_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46693">
        <property type="protein sequence ID" value="CDE46693"/>
        <property type="gene ID" value="BN770_00996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436197" evidence="1">
        <location>
            <begin position="31"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="180" mass="19513" checksum="EA9F11AA6D615F5F" modified="2013-07-24" version="1">MMMKKLIALLVCILLLATAQAEAPANTSAAETTEYGWALKIGRTAAKGMPIQDLLNTLAAQDCPAVFAVCGWTGFMGAAPSEYAGYVMLLFPGEVRIMLNIKPDDDDENAEAEWNALMESHAAAALTAENIAAAVPNWKIDDVMLSSNNGTDGFFYVDLEDYVSPEDAFDTFEFNIIKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6M2</accession>
    <name>R7I6M2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombination protein MgsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47136">
        <property type="protein sequence ID" value="CDE47136"/>
        <property type="gene ID" value="BN770_00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="49"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="442" mass="49395" checksum="8CFFB880A0BAE16A" modified="2013-07-24" version="1">MPQETLLTAANPPAPLAERLRPQNLDEFAGQEHLLGKGKVLRRMIEGDLVSSMIFWGPPGVGKTTLAQIIAHQTKSHFINFSAVTSGIKEIRQVMEQAESDRHFGVRTIVFVDEIHRFNKAQQDAFLPYVEKGSIILIGATTENPSFEVNSALLSRCRVFVLRALTEENVLTLLHRALRDERGFGGQKIDMAEDLLRAIAVFSNGDARTALSTLEMVILNADLDENGLAHVTQETVAQCTSRRSLLYDKKGDGHYDLISALHKSMRNSDPDAAVYWLARMLEGGEDPLYIARRVVRFASEDIGLADSRALETAVAAYQACHFLGMPECTVHLTQAVVYMAMAPKSNALYVAYETAKKDAQEQIAEPVPLQIRNAETSLMKNLGYGKGYVYAHDTQEKLSAMTCLPDSLQGKRYYQPTEQGNEGRYKQRLEEILKWKEEHRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7I703</accession>
    <name>R7I703_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ileS</name>
        <name evidence="14" type="ORF">BN770_00097</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000046">
        <property type="protein sequence ID" value="CDE47430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47430">
        <property type="protein sequence ID" value="CDE47430"/>
        <property type="gene ID" value="BN770_00097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="18"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="681"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="594"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE47430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1044" mass="119734" checksum="6D07B1A16426F159" modified="2013-07-24" version="1">MYNKVAKDLNFPAREKEIAQLWKDKDIVRRSFHFRDGAKRLTFFDGPPTANGRPHIGHIETRVIKDLIPRYWTMKGYSVLRKAGWDTHGLPVELEVEKTLGLDGKPQIEQYGIEPFIKECKKSVWKYLHDWEVMSDQVGYWVDMEHPYITYENDYIESEWWSLKEIWKKGLLYQGHKIVPYCPRCGTALSSHEVAQGYKTVKETSAYVRFPVKGEENTYLLAWTTTPWTLPSNMALCVNPTDTYCRFKAEDGRVYIMAKALMETVFPEQSFEVLAEMPGTALKGMEYVPLFDFAVGKLDKKAWFVICDNYVTMTDGTGIVHIAPAFGEDDNRVCRENDVPFVNFVDPQGCMTAETKWPGVFVKKADPLVLADLQERGLLFSAPQFTHDYPFCWRCDTPLLYYARPTWFIRMTALKDNLVRNNRTINWMPENIKEGRMGTWLENVHDWGLSRERYWGTPLPVWKCSCGNMHVVGSRAELREMAIEDPGADLELHRPFIDAVKLRCEKCGGEMVRDKAVIDCWYDSGSMPFAQWHYPFEHQEEFQQNFPANFISEAIDQTRGWFYTLEAISTLLFDRAPFENCIVLGHVQDEQGRKMSKHLGNVVSPFDELNKFGADALRWYFYTTSAPWLPSRYSEKAVREGQNKFLATLQNVYAFFAMYADIDNFDPTAHDLKNEQLSLMDKWILSKLNTLIKRVDDDLWNYRVTEPALAIQDFVDELSNWYVRRGRERFWGKGDVKDKDAAFTTLYHVLVTLSKVCAPFIPFLSEEIYQNLVVNNVPGAPESVHLCDFPTADESAIDADMEAQMDALVEVVQLGRACRNLANIKTRQTAAKLYVKGASFSESYQALCEDELNVKEVVFTESAREFTTYQLKPQMRTLGPKYGKLLGKIGQHLQTMDGNDVVDAFERGETVSFDIDGTLVTLGKDDVLTSPMQKSGFVAQEDKGVTVVLDTNLTPELIAEGYVREVVSKVQTMRKESDFDVTDRVDVRYECGDVLASAIESGVDMLKRGTLAEVVERAPMDDTFIVRDWSINGQDCKLGVRVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7A7</accession>
    <name>R7I7A7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain-containing surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000037">
        <property type="protein sequence ID" value="CDE47163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47163">
        <property type="protein sequence ID" value="CDE47163"/>
        <property type="gene ID" value="BN770_01159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="604" mass="66452" checksum="A1FC668EEE035627" modified="2013-07-24" version="1">MYLFAPPPVSLEIPATLGGYPVTAIGGWLFSSLDVCPVDAPFEVVFPEGLRALDADTFAECFYAVKVTLPATLEIIPEGCFDQISAEIEFPNGNPRYSCENGFLIDNTTQTLLYTAPSSHGNPLPAVRRLGDCSLMNWLWDDDDDPVLPDTLESVGSYIFYDCGVTRVTFPDGITELSPYTFYCTDLQEVHLPASLREIPDYCFWNCQLIALTIPDGVTRIGAHAVDWFTGEIIGAVTLPASVEFVGYRAFPDECDVTALNPQVHFETAAEYAERIPEYDWYGDEAADVLYSDGLFDYELSSRGAVLLGCSRFFNQPEVPDVLEIPSELGGTPVVAIAANALNTSESCADSLLFGIVLPEGVQRVEADAFQCCHAATQISFPSTLTMLAEGSFFHVYAEIDFPNGNPRYSCENGFLIDRDMQTLLYAAPSSQGQPIPAVRRLGDSALDNWKPAGNEIRLPDTLESIGPYALDGQYTGDFSPLAALILPDGVRELSDCSIYGCWEIQLLRFPATLTEIPAYCVANCGLGAVEIPEGVTRIGEFAFYYYDWEQTELSAVTLPASVEFVGFRAFPDECEITALNPDTHFETEEEINQRNPDWAYRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7T3</accession>
    <name>R7I7T3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase AAA-2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46577">
        <property type="protein sequence ID" value="CDE46577"/>
        <property type="gene ID" value="BN770_00944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="437"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE46577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="829" mass="91855" checksum="D2C3C7321D92798D" modified="2013-07-24" version="1">MAIFGQFTKRAQQVLMTAQECATREGQPYVGTLHFLYGLLDVGEAPESVTRHIQKEDVKQVLDQIDDEVSLHPGHGPVQMTPRARRVLDGSIIESRRLGQLYVGTEHMWLGILANPNCKAAELLAHRGVDASEAREELLARIRQRKAETPTPPFAAMGDGNGDNRQQVPQMPPPRRKDDQSALAQYGRDLTRCAENDELDPVIGRDTEITRLIQILIRRTKNNPVLIGEPGVGKSAVVEGLAQRIVAGNVPDMLMGKRVVSLDIGSMVAGSKYRGEFEERLKNVLSEIQKAGDVLLFIDEMHTIVGAGSAEGSLDAANILKPALARGELQCIGATTLDEYRKHIEKDAALERRFQPVHVGEPTTEETLAILHGLRERYEKHHQLHITDEALEAAVTLSDRYIADRYLPDKAIDLMDEACSRVRIQAYTAPPDVRKQELALEKVLADKKEAIAHQDYETAARLRDEERCLKAEIDQKREAWNEGKPKVELSVSEDDVAAIVSGWTGIPVTKMTQSEKERLLHLEDVLHARVIGQDEAISAISRAIRRARAGLKDPKRPIGSFIFLGPTGVGKTELCRALGEAMFGDESAVIRVDMSEYMEKHTTSRLVGSPPGYVGYEEGGQLTEAVRRKPYSVVLLDEVEKAHPDVFNILLQILEDGRLTDNTGRTVSFKNTIIVMTSNAGAHDIGEGRAMGFGSKALADATNYNAMKDAVMKAVKDVFRPEFINRVDELIVFHPLTEVEIRAIAGMMLGQVASRLKERAIALTWDDEVVEKLAREGYDVKFGARPLRRLIQRTVEDTLSEELLGGKIALGDRVRLKVADGKITVEKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7T4</accession>
    <name>R7I7T4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphonopyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47328">
        <property type="protein sequence ID" value="CDE47328"/>
        <property type="gene ID" value="BN770_01210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033980">
        <property type="term" value="F:phosphonopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032923">
        <property type="term" value="P:organic phosphonate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017684">
        <property type="entry name" value="Phosphono-pyrv_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03297">
        <property type="entry name" value="Ppyr-DeCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="231"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="379" mass="40542" checksum="18D85C4139BDD1E4" modified="2013-07-24" version="1">MDAQRLLSACEGAGIDFFTGVPDSQLKGLCDSLYALYGVHSPRHIVAANEGNAVGLAAGHFLATGRPALCYMQNSGLGNAVNPLASLMDAQVYQLPCLLVVGWRGEPGVHDEPQHVKQGQITLSQLEILGIPCRILSKDTTEEQFAADFAFLREQLNQRRCAALVVRKGALTCSLKPAYGNENTLTRERAAEIMLNAMDAGDVVVSTTGKLSREIFELREKRGEGHERDFLTVGSMGHASMIALEIALEKPNRRVWCLDGDGAALMHLGALPVIAQRKPANLIHVVINNAAHETVGGMPVCEGGLCAAKVASAVGYPRVLNARDEATLEAALQEAKGANQLTMLEVACAVGARADLGRPTTTPIQNRDALMAFLREEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7W9</accession>
    <name>R7I7W9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6273 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000044">
        <property type="protein sequence ID" value="CDE47368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47368">
        <property type="protein sequence ID" value="CDE47368"/>
        <property type="gene ID" value="BN770_01222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046240">
        <property type="entry name" value="DUF6273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19789">
        <property type="entry name" value="DUF6273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448062" description="DUF6273 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6273" evidence="2">
        <location>
            <begin position="71"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="375" mass="41613" checksum="09B26245A7C6BE03" modified="2013-07-24" version="1">MRNKRILSFLVALVSLLTLLPAASAANDVYVGQTFYFGSYEQDGNLRNGDEPILWRVYSVDYGSRTVRAVSEYGLDSMVYNRSTSTTSWHNSTIRSWLNSTFLSSAFTSAEQGQLNSVYVSNSSDYVYILSQWEIQQYLDTELLYATEYARQCGAYTASDTGTSSYWARVDSTSTFGVFVGAHGSFYDHGNKVTEFDNAVRPAICVSFDVALGRWTPSSSDSSSGLLAMSNRPISTRSGPSTKYDELGTYWNDGGHTVTVLSRASGNDIWWLQVEFEYGGKTVRVYTGEQRIDIDVSRVPIEGGAIGSGRVTSTTTAYYGPGTNYKQHQQKISSGTTGAVMAWENGYVCLEFQLSGSYQIRRVWLPENVVSITYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I853</accession>
    <name>R7I853_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000057">
        <property type="protein sequence ID" value="CDE47686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47686">
        <property type="protein sequence ID" value="CDE47686"/>
        <property type="gene ID" value="BN770_00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="69" mass="7811" checksum="2466D4C012F113BC" modified="2013-07-24" version="1">MKRTLPALLLCGVLLFSVPALTEDALLRSLFGWTAYFARIPADAADTPDTLEWDWTWNGFWRALFGYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8H1</accession>
    <name>R7I8H1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000062">
        <property type="protein sequence ID" value="CDE47776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47776">
        <property type="protein sequence ID" value="CDE47776"/>
        <property type="gene ID" value="BN770_01354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436255" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="194"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="446" mass="50173" checksum="F7FF3000889B06D6" modified="2013-07-24" version="1">MKRFSRLVAAMVALALVLTGVVFAETQGTIAERYQDALSRLERYLMNLQGDSVNITTLAEDFQKLGNYEGSNAFYYYTLVLADASANNYTLIPMYIDALVINTSFDERLTNLRANGVNIPSVAEWAAYLNGRVAESEGNYAEAAEQYQQCLNFMDAQNRILYALAWSRQTSAAATPAPTAAPTSAPNNANTTVTVYPPTLYANVSGKAVSLEWTTVSGATNYSLYRRRTNYDKNFQLIYSGSSLSYKDTSANANYNYTYYVAATTKEGRQLSSNEKTALISSNSASNNTSTTTTKPPVTKRPVTNPPVTTPPITKGPTPTITTTPTPPPQWSAWTQWSTTPVSSSSTRQVETKVETETYSIPVYHYSRWHYYNTGYNKWYYSYAEYTGSNYKPGTGNWEYMSSYEPLSKNGTADGHQRYENYWWNETVSYEQDSYEVTYYRYRDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8T0</accession>
    <name>R7I8T0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 1 extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000057">
        <property type="protein sequence ID" value="CDE47688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47688">
        <property type="protein sequence ID" value="CDE47688"/>
        <property type="gene ID" value="BN770_00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435557" evidence="1">
        <location>
            <begin position="22"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="787" mass="88771" checksum="90CF8F9E07EF57D2" modified="2013-07-24" version="1">MRARRLLILLMMLLLLPQAQAERLTLYTRPNNVDEATPFQLRPTELSICSVTRAMGGAVVLAYDHNYDSLSLYFWQDGMTEMRKLGGGFYWVMSGDTMETAQQSCEYSMSRVPNYRMPDLTHAISNLTSDGETLYALNRINGLIFKISETKDGLQTEDVCTMANLSCLNVSYRDLETDKVYTYPASLTRMHVCGSVLAISVMQENGIKVVLVDLTDGAIREIADESLEAMYEWADGELLLWRLEGSTNEISRSSGTYTLSRYSVATGEETLLSTGVPYKKRSECGAYDPYSGSYYDVRTRQIVRTTDFVQEEPVVTFPAANVNIAVTKDSIVGVNLSSVYVRSKENGDMTVLRIQSSNGASNTALQHFAEENPKVILAQETLMQSAMNAASLAARMSASADAPDILRLGLTPDTPEADGSWPLDVLMDKGWCMDLSVYPEVSDYVSRLNGVYRDAVTRDGKIYALPIYAWSYGYFISRNVMEKLGLQESDIPTNLIDFCAFITKWNDNLTGAYAAYTPLEETESYRERVFDLMVHDWIGYCQAENIPLRFDHPVFREMMAALDAMRTDKIEQANQQVNEEISDYRECLIWTDAQAVGNFANYADAFGSRIFLPMALTPDVTTHYGIGYMTVLVVNPRTMNADLVGKMLAQVIADQEATAKCVLLADYDEPIEDSYYLIMVRDYEKTLTELRRQQENAPAWKKQGIQERIDEEEASLQRYTVRERWTIAPKTIEFYQQTILPMSYLRRPGILADSDAFSALVSQVHQGEISLEEFVEKADKLIEGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I916</accession>
    <name>R7I916_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide/dipeptide ABC transporter ATP-binding protein C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47996">
        <property type="protein sequence ID" value="CDE47996"/>
        <property type="gene ID" value="BN770_01478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="118"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="469" mass="51917" checksum="1323E1A779BA6B61" modified="2013-07-24" version="1">MKQLETCPPVQAAEYVPVAGDFAQLEQADIATDTNYASQGYWKGVATHFVRNKRAMIGLILVLLMIFLAFVAPLFSGYAYDEIVTALNAKGRKKAAVGISPRVPAIHEMVTGEAYDDIYADKTFSFRTNAGVVHAIRGINLNLQKGETVAIVGESGSGKSVTMKAAVGLLDSNATIHSGEILYTYDDGHGQDKTVDLLKLSKKQLRTEYNGQRLAMVFQDPMTSLDPTMTIGKQIMEGMLLHKHMPKDEARTKALQLLELVGITDAEKRFRNYPHQLSGGMRQRVVIAIALSAEPDILICDEPTTALDVTIQSKILDLIKQIQQKMHLSVIYITHDLGVVAKVADYVNVMYAGKIVEVGNVEEIFYEPCHPYTWGLLSAMPDLETADDRLYSIPGSPPNLLHEPVGDAFAARNRFAMVIDKKAEPPLFKVSETHYAATWLLHPDAPAFEMPKELKERLERAKKEAAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9B7</accession>
    <name>R7I9B7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type transporter integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48474">
        <property type="protein sequence ID" value="CDE48474"/>
        <property type="gene ID" value="BN770_01712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="82"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="321" mass="36427" checksum="1B1ED3C3E45C73F3" modified="2013-07-24" version="1">MSNPTLVHGKRQSLGKTIWKHRASYLLMAPYFILFFFFTVLPVLMAIGVSFTDWNMLEKPEFVGWQNYVKLLLDDEIFIISLKNTLIFAVITGPVSYMLCLLFAWIINEFNRGMRTLLTLIFYAPSICGNAYMVWNLILTGDRYGYFKGILLNLDIINGYLNGILLNLDIINEPILWMKTEQYVMPMLIIVQLWLSLGTGFLSFIAGLQTVDKSMYEAAAIDGIKNRWQELWYVTLPAMKPQLMFGAVMQITQSFAVADISINLAGNPSVNYAGATIVTHLLDYGSTRMEMGYACAIATILFLLMVGTNKLVQRVLRRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9C9</accession>
    <name>R7I9C9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48101">
        <property type="protein sequence ID" value="CDE48101"/>
        <property type="gene ID" value="BN770_00111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435657" evidence="1">
        <location>
            <begin position="21"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="502" mass="55010" checksum="2B21D9EACAFB44D2" modified="2013-07-24" version="1">MRKILAMLLSVMLLLTAAVAETSAPYAPETVLPLVANNRPYRDFARGAISSSEDAIEQAKAWLYLPLFVTNFSAKSEAVDWSAMHAEEGWYVTAYMRNTFVWLLMDEQGRVQAYDFDLLGNASLTYDGALPDNLDEAISSYIRRFADLNGFVKVADYAREEVTTFGDYAVAVTVQVTLDGTPYRFTMRLDMMAFTSVENANLHPTAAQTQRDILLLMRDNLAEKGVDVAQTFFAVQADDADGETKLTGIASFPADAASDAIREQYGELERYTLHYSGRASEAGIERVELSDWQETTATAQFPLALYALVDGKYLVPDGELAAGTAYLALDSMGLRGRNVIPLESITMLTRIRYARADGTFAESWVSSDTLTENDAAPAAPKREPIPTLESYQITLSGTAYTAFAINKVEKGYDTFADIAGTQTAVVDVLTSAAQGVIAEYGVDASDLLCRTVVEYGYRADKGCWQVDFTIPQRDVADDAYEVEVDDKDGKVTGMWGPQDGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9F3</accession>
    <name>R7I9F3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47908">
        <property type="protein sequence ID" value="CDE47908"/>
        <property type="gene ID" value="BN770_01423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="78" mass="8199" checksum="2A8D496BE8F1E914" modified="2013-07-24" version="1">MSAFGVVLTVIITISALFMIFTVLMQSSNVKGLGAIAGTFDSYFDKHKAKSAEAKLALGTKIAAAIFVACSLLMLLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9I1</accession>
    <name>R7I9I1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endopeptidase La</fullName>
            <ecNumber evidence="3">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47948">
        <property type="protein sequence ID" value="CDE47948"/>
        <property type="gene ID" value="BN770_01448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014251">
        <property type="entry name" value="Spore_LonB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02902">
        <property type="entry name" value="spore_lonB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="92"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="6">
        <location>
            <begin position="348"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="558" mass="59850" checksum="DD9D311DF18869D2" modified="2013-07-24" version="1">MFATMLVVIQLVVSVVVGLYFFRQLRQSRQKEPAHGRESNREMERMRHLRSIHLSEPLAEKVRPTKMSDVIGQEDGIRSLKAILCGANPQHVLIYGPPGIGKTCAARLVLEAAKQSQGTPFREDAPFIEVDATCVRFDERAIADPLIGSVHDPIYQGAGQLGAQGVPQPKPGAVTKAHGGVLFLDEIGELHPVQMNKLLKVLEDRRVMLDSAYYNPDDATIPRYIHDIFHNGLPADFRLVGATTRSPSEISPALRSRCMEVFFRALTPEEIALIASGAAERAGCAMAKQEAETIGRYAACGRDAVNIVQMCAGLAQMDERTMILPEDVAWVVQSGHYTIHAQQKADVSNRVGVVHGLAVYGENQGALLDLEAVATPGHGEITVTGIIDEEEIGQEGHKMRRRSTAHGAAENVRTLLKSLGYTLENTDLHINFPGGMPVDGPSAGVAMAVAAVSALTDTPVEGTMAVTGEITVQGKVKAVGGVPQKVEAACQAGLLRVLIPKENDAETLHIAGIDVQGIDDVHQALSAMLVHTKTAKKLIHSPLPMTEKVAAAAAEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9S6</accession>
    <name>R7I9S6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Central glycolytic genes regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47252">
        <property type="protein sequence ID" value="CDE47252"/>
        <property type="gene ID" value="BN770_01180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="88"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="345" mass="36979" checksum="5DE7C8CA2269C7C3" modified="2013-07-24" version="1">MALMQAIAPEMAEAMARRAMVLTAIAESAPVGRRQLALRLNLAEREVRADVEKLRDAGLITLDKAGMNPTPNASRWLESARSFARQTQGLTALETALMQVLPVKTVFVAPGDADADVRVLSDVGRLAAQGVRQLLHSGSTLAVTGGSTIAATAHAMQSSAPMNVMVVPAQGGFGREVETQANTLAAEIAQRLGGHHRLLHLPDHMDEQAKQEMLRLPEIRETMERIQRADIILHGIGCAQETMSRLPVEQVRLLMKKGAVGESFGAYYDRDGQCLLKSSGVCVDLARLTPDCRMIAVAAGAKKAEAIISVLRHDPHTLLVTDEGAAKQMLAILKTNTGCSSDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9W7</accession>
    <name>R7I9W7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative SWIM zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000042">
        <property type="protein sequence ID" value="CDE47302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47302">
        <property type="protein sequence ID" value="CDE47302"/>
        <property type="gene ID" value="BN770_01203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="557" mass="64876" checksum="36648FE5B53C2017" modified="2013-07-24" version="1">MHITDWRENFISKMITRGRNYWRAGAVKNLHCTQEKITADVEGTRLYRVEITLAGDAVATLSCTCPFAKEGANCKHMAAVLFAATHLPESELPAPEWEKKLNSLSAETLRDFLRPLLKKDEALRNRLMLCKGDEPVRADERRLNWQRTLTQTLHAAERYSENEYDEYAEYDEEEYDEEEESPVQELLELMDAELADLLTPEHVMLAFELVCDTAMMFESADEILEQEDIEDACRDAWMRILAIAAPAQQSAMYEWFAAAFRTWKPLPYFTAPLAFLFSYSWDEAIHQRNLALLDEKIAEWKPNAQERGGGAMVNLLNQREKTMQQLHASQEDIISFWHSHWDVPYAHDRTLKTLMAAEKWAEAIEQVKADLQTFAGEYMPCKQRREQLILLYQRANQPDLAQREIRQYIEQYNQYSMEQIDALRATLPADAWRDEAERLLKLPTTSTIRLPLLASIEQWEQLLQRIQQHGNFEGLCTYFDPLMAWDSARTLALYRDMVNRAMQGASSRATYCEIIQRLERMKGTDEGRQIIADLAVQWRRDYKRKCALLDELQKAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA55</accession>
    <name>R7IA55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48744">
        <property type="protein sequence ID" value="CDE48744"/>
        <property type="gene ID" value="BN770_01803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034308">
        <property type="entry name" value="VPS70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="PTHR10404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="PTHR10404:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435621" evidence="1">
        <location>
            <begin position="22"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="136"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="3">
        <location>
            <begin position="256"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="716" mass="79712" checksum="BA36C7B09C0D9808" modified="2013-07-24" version="1">MFIFLLILFVCILLLPSCARADEAPAAHQRRSLQSLHDAFSSAANSQYAYSIAHRLATDFHLHNNATYGGRQAGSDAEHAAADYLADEMRRIGLSDVEKAAAKCDKWQFNGASFTVNGTEYPVYTYATASTVPEGITAPIVYVGRGTMYDYEGVDVKGKIVLVDIDQRADWWITYPMLEAEHQGAAAILAANVGGFGQVADDALNSQDICGPTSIPTCSIGVRASREIRAQLPHGTVLGTLKVDNTVEIGKGTTYNVTGRIRGKSSEFQILLGGHYDTHFWGFQDDCCAVGLVLAAAKAMLDSGFEPENDIVFCLHGAEEWGSSYTQFDWTVGAWEMINTLHPEWVGKTLAFLNFELPAYEFATYTTTYSAPEMFSLLRDFTTRYPYAPKPQGCFPDGVLTEGYQTYTYSDDFSYYAAGVPSTVNGFLLQKDMEHVHPFYIDYYHTQYDTPDTYNDAVMAFNLRYYGALAIYIDQMPALQLDFTAQYTRLKDALDADIFAQSGADAALYRGVVESLLPPAQALKARIDTLNARYLAADEAGDTAEMTRLRQAGRPLIRKVLNAFRYCQKYLLGLMYERPIVPHQAPQETIALCQHIIDCLVRHDPATAVDQYVATVNNCLESYSIYFSPAVIDTLNDMNWGAGNQDNLYFGTNINFDKAEVEEASRSVYQRRAEIGGDFAKEIRVYRDAIDMEKKKLRADVHKETEAIGWLKDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA80</accession>
    <name>R7IA80_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaX</name>
        <name evidence="8" type="ORF">BN770_01680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48391">
        <property type="protein sequence ID" value="CDE48391"/>
        <property type="gene ID" value="BN770_01680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="37"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="541" mass="59593" checksum="BDC605CA4935CDB9" modified="2013-07-24" version="1">MAYQALYRQWRPKDFSSMVAQEAVISTLRNQVMSGRVAHAYLFCGSRGTGKTSTAKILARAINCEHPVNGDPCGQCESCRRLLADESMDVMEIDAASNNGVEEIRNLRETVKYPPQQGKYKVYIIDEVHMLSTSAFNALLKTLEEPPAYVVFILATTEPQKLPATILSRCQRFDFGRIPAHQIAGRLRQAAEGAKAEASENALMLIARAAEGGMRDALSILDMCLGYSNQVTEDLVRNVLGTSDRSFLFRFADALEKEDASAVMRMIDELMRAGREPMVFAKDVSQHLRALLIAKCSPDDLSALLDLTQEDAQEYAQQAEKFTTTRLMHMLELFMRVETDLRWASSPRIVLENAALKSCLRTSEADTAALNDRISELEKQLTALQEKLQSGAFAPAQPAKKAAKPASEPKQEAPKPAAPPVMTPTGKTDADAWKEAMNILKRSDPGTFAMLTMGKYAGCDGDTYRWQAPMGQELYVGLMNQEKKRAAIASALTQASGMQCRFEAIGAVKEKKADQSDESFLAALETTFGKANTMVQEDVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAT7</accession>
    <name>R7IAT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BH1295 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48606">
        <property type="protein sequence ID" value="CDE48606"/>
        <property type="gene ID" value="BN770_01747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435707" evidence="1">
        <location>
            <begin position="27"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="696" mass="74486" checksum="206946B802662198" modified="2013-07-24" version="1">MMNSGLRRLLSGAVALMLLGCSSALADTATVTARKLILREKASSTSDALQTLPKGTKLEILGKSGSWYKVTYGKYTGYVYKTYVSVTKTASSSSSSSSTTRLEKGSTGSDVKDLQKKLKKLGYYDAYVDGDYGDTTVAAVKAFQKKYNLTADGIAGKETLKKLDSAYKNADSDKDDDSLRMGDSGSAVKDLQTKLKKLGYYSGTVDSTFGSGTYAAVRAFQKKYNLTADGVAGSETLKKLDSVYKNADSDKDDDSLRMGDSGSAVKDLQTKLKKLGYYDGTVDSTFGSGTYAAVKAFQKKYNLTADGVAGSETLKKLDSAYKNADSDKDDDSLRKGATGSAVKDLQTKLKKLGFYNAYVDGSYGDTTVAAVKAFQKKYNLTADGVAGSETLKKLDSAYKNADSDKDDGSLRKGATGSAVKNLQTKLKKLGFYNASIDGDYGDTTVAAVKAFQKKYNLTADGVAGSETLKKLDSAYKNADSNTSTDDDSLRKGATGTAVKTLQTNLKKLGFYTAYVDGSFGSTTESAVKAFQKKYGLSADGVAGSATLKKIESAVASASSGKITTERLDWFNGGKYVIPNGAVFQIKDVSTGLIFSARRQSGGNHMDAEPLTAEDTAILKKINGGTFSWRRRAVLVKYNGHVYAASIYSEPHGTNTILDNNFDGQFCLHFYGSKTHGTDRVDADHQKCVEQAMKATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAY7</accession>
    <name>R7IAY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49069">
        <property type="protein sequence ID" value="CDE49069"/>
        <property type="gene ID" value="BN770_01909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="252" mass="28636" checksum="FA26E52D2D83D044" modified="2013-07-24" version="1">MYVLLFFACSFLGWCMEVTCKLVQFGRFINRGFLLGPLCPIYGTGAVLMAYFLPLWTTQVESTFLLALVLCGTLEYITSWLMEKLFHARWWDYSQKRFNINGRVCASNLLAFGVMGVFVVKVLKPFAFGLFAKIPPVWLDAITITLTALLIADVAISAGVLTKIRGAAESVRADNTEAITKAVREALMAQGFLLRHPLHAFPEVQFYNKAHLARLKAKHDELQANMREKREKLQQELERLEEKRKALKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBC5</accession>
    <name>R7IBC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48613">
        <property type="protein sequence ID" value="CDE48613"/>
        <property type="gene ID" value="BN770_01753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33248" checksum="27B630F4B712A2CD" modified="2013-07-24" version="1">MFLADTHSDTLFSLGVGKRTFAQTDITPDRLRQGGVSLQTLALWSGPKGPNGDYEAVADAEYAAIRHFTDAGIRHVDDPEDVKPGECTFMLSFEGCEVFQKSDEMVAFWRQRGIRIGALVWNHPNAFATPAAVDAETHMTPEGIRIARVMQRQGISVDVSHLNEAGFWDLFAKGERPPMASHSCCRALCDHVRNLTDDQIRAMIQYGGYIGVNFYPRFLSADCKADSVTIAQHIDHICQLGGSDIVGFGSDFDGIEVSPDDVRNPAELPNLLTALRNYGYNDESIERICGGNLKAYFARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBG5</accession>
    <name>R7IBG5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division initiation protein DivIVA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48930">
        <property type="protein sequence ID" value="CDE48930"/>
        <property type="gene ID" value="BN770_01869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17528" checksum="A2FD1240EE650BED" modified="2013-07-24" version="1">MEQRITVDSILDKKFSTVAKGFNQQEVDEYLDQICDEFDRRDAEMNTLRQEIAQLKAAQANGSNTVPQQTRPEAATDDSFREILEMAKRVKDQTIADAQTKASQILANAENEARQQLSDLTKQKEDLTAQVNSLKASAKSYYEQAQNALNGLSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBR1</accession>
    <name>R7IBR1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Formate acetyltransferase</fullName>
            <ecNumber evidence="5 14">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BN770_01447</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="5 14"/>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47947">
        <property type="protein sequence ID" value="CDE47947"/>
        <property type="gene ID" value="BN770_01447"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0556">Organic radical</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="16">
        <location>
            <begin position="1"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="15">
        <location>
            <begin position="625"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="13">
        <location>
            <position position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDE47947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="750" mass="84327" checksum="23CD45B42314DCD5" modified="2013-07-24" version="1">MYNFEQWNGFKGSIWKEEVNVRDFIQKNYKPYDGDESFLVGPTEATDKLWGALQKLQKEERAKGGVLDMDTEIVSTLTSHKPGYIDEDLKDLEKVVGLQTDKPLKRAFMPFGGIRMAEQSCTENGYTPAPELHKIFTEYHLTHSDAVFMAYTPEMRAARKSHIITGLPDTYGRGRIVGDYRRVALYGIDVLIAEKQHDFANCGDGTMTDDVIRQRQEITLQVNALKDMKVMAASYGYDISKPASNAHEAFQWLYFGYLAAIKTQNGAAMSVGRISTFLDIYVERDLENGVITEAEAQELVDHIVMKFRMVKFARITSYQELFSGDPVWATLEVGGTGLDGRSMVTKNDYRFLHTLENMGPSPEPNMTVLYTSRLPEAFKKYAAHISIVSSSIQYENDDVMKPVWGDDYSICCCVSATQTGKEMQFFGARANLLKALLYAINGGMDEKLKTQVGPCYAPITTDELTWDIVKPAYLRMLDWLAGLYVNVLNLIHYMHDKYYYEAAEMALIDTHVKRSFATGIAGFSHCVDSISALKYAKVTAIRDESGMVYDYKTEGEFPKYGNDDDRADDIAKWLLKTFIDMVKKHHTYRNSEPSTSILTITSNVVYGKATGSTPDGRRAWTPLAPGANPSYGAEQNGLVASLNSTAKLPYHWALDGISNTQTINPDALGHAAGERVNNLVQVMDGYFDQGAHHLNVNVFGKEKLLDAMEHPEKEEYANFTIRVSGYAVKFIDLTREQQLDVIARTCHTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBV8</accession>
    <name>R7IBV8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">recX</name>
        <name evidence="6" type="ORF">BN770_01989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the RecX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49379">
        <property type="protein sequence ID" value="CDE49379"/>
        <property type="gene ID" value="BN770_01989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="206" mass="23705" checksum="10B0BA692D14A393" modified="2013-07-24" version="1">MDIITRITRQRGKMQIVISEQETIVVPLSLFRERPLTEGQPINLEEYDNWLMVRQYRHALDRAVACLAARAHSKHEIEQKLLRVGYRPCTVEMVLYKLEREHLLNDADFARQWVEARSGRKLGRSRIAQELRRKGIDADEAEEALSAIGEDDQLANAIALAEKAAARAKSDEDPRKTYQRIAAMLARRGFRWDITKEALAQVLQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBZ6</accession>
    <name>R7IBZ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="3">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asnS</name>
        <name evidence="5" type="ORF">BN770_01827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48808">
        <property type="protein sequence ID" value="CDE48808"/>
        <property type="gene ID" value="BN770_01827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="4">
        <location>
            <begin position="135"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="456" mass="52012" checksum="83B488F0327DABF8" modified="2013-07-24" version="1">MNVLTTRELKERLNELQGQTVMLQGWIRNHRKQKNMGFIDFFDGTCFKNPQVVYDNTIEDYAAIQTLHVGAAITVTGKVVPSYKDPTTPEVQAIAIHLEGDCPEDYPLQPKRHSVEYLREIAYLRPRTCLFQAVFRVRSVASMAIHTYFQDRGYLYVHTPLITANDAEGAGNTFTVTTLPPSEQKDGSNDFFGKPTSLAVTGQLEAETFAMAFSKVYTFGPTFRAENSNTKTHAAEFWMIEPEIAFCDIHQLMDIEEDFLKYLVKTVLEKCSDELEFLDKFTGGGLLDKLNHLAVTGAARITHEEAITILRKVKDRFQFEPKYGEDTAKEHEKYLTEEYFHSPVFVYDWPKDIKAFYMYQNDDGKTVAAVDLLVPGAGELMGGSQRETRLDKLTERMDALHISKDAMYWYVNLRKFGGCTHSGFGMGFERLLIYLTGVDNIRDVIPYARTPMNCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC44</accession>
    <name>R7IC44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49066">
        <property type="protein sequence ID" value="CDE49066"/>
        <property type="gene ID" value="BN770_01908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447795" evidence="1">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="287" mass="30704" checksum="27BBE36B3AA900E6" modified="2013-07-24" version="1">MTRKLISILLILLIFSSAAHADAPVLDLRAHDADARFPSDASVLTVAFPQMTFADAAILVCDGHAGMIDAGGYAEESAVQTALEALGVTRLDWVVATHPHHDHQPGFEAIARRMPIGRFLTSFPANENAQMQHTLAVMADCGVPIENASDGQMLTLGGAQIRLILPENTGKTINNRSLLALVTLGDARMLMLADLESMGQQALLDSGDDVHADILKYPHHGHAAMNQALLTAIATKLAIITAKPTRAPYALAQLDAMAIPAAHTDECGLLLQTDGQVWILQNLMMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC67</accession>
    <name>R7IC67_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49185">
        <property type="protein sequence ID" value="CDE49185"/>
        <property type="gene ID" value="BN770_01930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="351" mass="39522" checksum="DF86D6C766FF080E" modified="2013-07-24" version="1">MSHQRAGDCQALTLTAGQVASALLHRIIELARLLADKILRLRNGQRVPQFFVRGILVAPEQIRANRPLEQLRLLHDDRNVAVQLRLGIGGNRLTEQGDLPLRCVIKARNQADERRFAAARAADNADGLPLLCREGHVGQAFRTRALIAQGHMLERHRHIGSSIRRNGLLRECHRRGRIQHLRHAAHAGNCAGEQHDEVRQLHQFHQNLAHVVHQRHHVAGEQRAAANLVCAEVQNADDAEVDHDIRQRIHQRGNAADFELHGVQVAILLDEVFFLRVLAPERAHDADTGEVLARCARDRVQPGLNGFVHGRGDAHDAKDNHRQHGNRREENQRNLCINGEGGNHRARDDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICA5</accession>
    <name>R7ICA5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">BN770_01862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48923">
        <property type="protein sequence ID" value="CDE48923"/>
        <property type="gene ID" value="BN770_01862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="89"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="198" mass="22366" checksum="96730B10876C6FCF" modified="2013-07-24" version="1">MAINKQPVARKCRALGVSPAEMGYGKKQSKRNPGGIRRKKVSEYGAQLKEKQKVKFVYGVLEKQFHKYYLKATNMKGITGDNMLQLLELRLDNVVYRLGLGKTRRAARQIVVHGHIRVNGQKVDIPSYSVKVGDVITLRQKSTESELFKPLREGTSVVTPKWLTFDAPNLTGKVVALPTREDVSLEAEMSMIVEFYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICH4</accession>
    <name>R7ICH4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory membrane-associated serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49201">
        <property type="protein sequence ID" value="CDE49201"/>
        <property type="gene ID" value="BN770_01936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014219">
        <property type="entry name" value="Pept_S55_SpoIVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008763">
        <property type="entry name" value="Peptidase_S55"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05580">
        <property type="entry name" value="Peptidase_S55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02860">
        <property type="entry name" value="spore_IV_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51494">
        <property type="entry name" value="SPOIVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S55" evidence="1">
        <location>
            <begin position="186"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="416" mass="43332" checksum="36886CF001623E82" modified="2013-07-24" version="1">MKKHPSPLRRAVGLVLTLLLTLGYFSPTQQALRALPASLRLTQDEPISLLTGMLRASGEGLEVSASQDETLSQYVSVTGQKSGTSELLLSILGIPLRRVEVEVSPEKRLIPGGQALGVAMRTDGVLIVGLSDVKKGVCPARDCGLQPGDVLLRIGGHAIERVADVSEIAQQNGTSPLLIEYMRDGTTAHATLTPVQDDATGVVRLGAWVRDSTAGIGTLSFYDPDSGQYAALGHAITDGDTGSILTVREGRVLKASIVAVQKGQRGVPGELKGSFLQNAAVLGDIAQNTALGISGTLTTAVTNPLYPDGLPIGTRSSVHTGAATILSTIGTGGVQEYTVEVTHVSQQNAPAAKSMVLRVTDTRLLDATGGIVQGMSGSPIIQDGKLIGAVTHVFVSDPTQGYGLYVDWMLSTLIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICJ7</accession>
    <name>R7ICJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic binding protein and sugar binding domain of the LacI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49023">
        <property type="protein sequence ID" value="CDE49023"/>
        <property type="gene ID" value="BN770_01899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="345" mass="38077" checksum="1F6FC2E6EC6BF49B" modified="2013-07-24" version="1">MAVTIKDVSAKCGLSISTVSKAFNNYADISLETRELVQRTAREIGYYPNAIARTLKTNRSYNLGVLFQEKRGTGLTHSFFASVLDAFKSAGEKRGYDITFINHHIGWTGMTYLEHCRYRNVDGVCVVCADFYAPEVIELVDSNLPVVTIDHSFNNRSCVLSDNIGGLKLLVDAAYQKGHRKIAYVHGEKSSVTENRIIGFYRAMQEHGLNVNLDFVVEALYDNPATSMQAVLNLMNRPDPPTCILLPDDHSTLGAMQAAKQLNLRVPEDLSLAGYDGIRLTQMLQPRLTTIEQDTKRIGAQAAEFLIDRIENPRTAGSETATIPVKLLEGESMGICPVKADAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICJ8</accession>
    <name>R7ICJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxykinase [ATP]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000089">
        <property type="protein sequence ID" value="CDE48217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48217">
        <property type="protein sequence ID" value="CDE48217"/>
        <property type="gene ID" value="BN770_01583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27613" checksum="2079436EB67B82DC" modified="2013-07-24" version="1">MAELNLSKYGITGTTEVVHNPSYDLLFEEETKSTNEGYEKGQVSELGAVNVMTGIYTGRSPKDKYIVMDENSKDTVWWTSEGYKNDNHPMTESTWASVKDLAIKELSNKKLYVVDAFCGANKDTRMAVRFIVEVAWQAHFVKNMFIQPSEEELKNFTPDFVVYNASKAKVENYKELSLNSETCVAFNITSREQVILNTWYGGEMKKGMFSMMNYYLPLKGIASMHCSANTDKEGKNTTRGTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICS1</accession>
    <name>R7ICS1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49415">
        <property type="protein sequence ID" value="CDE49415"/>
        <property type="gene ID" value="BN770_02006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="140"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="232"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="373"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="454" mass="50061" checksum="BCB470D24EAE7417" modified="2013-07-24" version="1">MRILVVGDGKVGHTVAEQLTREGHDVVIIDKNEDVLQRCEDTLDVLCIRGNGANARTLLDAGVEKADFVVAATASDETNMLCCLIAKRLGARYTIARIRDPEYNESLSLLQRETSIDNAINPERATALEISRLLRFPFANNIETFAKGQIEMVEFRVQENDVVVGCPLHALSSRLPGIPRVLYAIVERSGEVIIPNGDFVIHAGDRVHVAGDMVTITNYFRFLGKHSLRVKNVMLLGGGRISYYLAKMIVPMGMHVAMIEINPKKAESLSESLPHVNVILGDGTDQELLEQEGLESMDAFIAMCDRDEENLMTGLFAVKQGVPKVIVKNNRLAYADIMNGMGLDSMVSPKTITCSTILRYVRALVNSDGTKVERLYRLMNGRVEALEFIARASDPYIGIPLKNLHIRKNALVAVIARQGKVIVPFGDDKIEEGDHVVIIVCENGIGDLNEVISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICS7</accession>
    <name>R7ICS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000095">
        <property type="protein sequence ID" value="CDE48312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48312">
        <property type="protein sequence ID" value="CDE48312"/>
        <property type="gene ID" value="BN770_01639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="310" mass="33858" checksum="05254AFCB7EE8E46" modified="2013-07-24" version="1">MDKKKKNSKTPPVSGFLARFRGFAQACAALLTNPHLPNLLQGQIYRGKGKTVCVPGLNCYSCPAATGACPIGAVQSVIGSSKFKFSYYVTGTLILLGVLLGRFVCGFLCPFGWFQELIHKIPLPKKKLSTKKLRPLRYLKYLILLLTVTLPLIFTNEVGMGNPFFCKYLCPQGVLEGAIPLSLASESVRSALGSLFTWKSVVLGAVVVLSLLFYRPFCKWLCPLGAFYALFNRVSLTGMQVDAHKCVHCGRCEKACKMDVDVTKTPDHPECIRCGMCVKACPTGAVSFRCGLSRGAKEKENPDGKQAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID28</accession>
    <name>R7ID28_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor P</fullName>
            <shortName evidence="8">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">efp</name>
        <name evidence="12" type="ORF">BN770_01705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48467">
        <property type="protein sequence ID" value="CDE48467"/>
        <property type="gene ID" value="BN770_01705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="11">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="10">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE48467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="185" mass="20824" checksum="F607D97A829166CE" modified="2013-07-24" version="1">MITAGDFKKGITVEWDGGVWTIVDFQHVKPGKGAAFVRTKIKNVMTGAVVERSFNPTDKMPKAIIETKEMQYVYNDGELYYFMDVETYDQIPMSLDKVEDAIPYVKEGTNVTVRFFKGQPFSVEAPNFVVLEVTDTEPGFKGDTASNTYKPATLETGYSLQVPLFVNTGDKIRIDTRTGEYMERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID31</accession>
    <name>R7ID31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannan endo-1 4-beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48472">
        <property type="protein sequence ID" value="CDE48472"/>
        <property type="gene ID" value="BN770_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448179" evidence="5">
        <location>
            <begin position="35"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="6">
        <location>
            <begin position="42"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="7">
        <location>
            <begin position="177"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="502" mass="55490" checksum="5FF091164C9592A9" modified="2013-07-24" version="1">MDKRATCRKILRKTALSVLAASILMTGTVDAVRAEETPNVLQTVEAESGTLLGKAKIAATGTCVSGLEHTGDGVEVTVTVPEDGLYDIIVRTAVIGGGTKVNEVNANGQHVGDITNSGSWSDEVVPYVWLEAGDNTVSVTASYGWIAVDSFSIRRAAPLPTDVYEVKPTLINPNATDSAKRLMTYLCDQYGKTVLSGQQSQDGAFGLTNAAVWRGTGGDYPAVLGMDLISYSPARVAKGDNSSNVVERAIEYWNGDEGKRGIVTLCWHWCPAARYDKSKSDPWGTFYTDKTKFNLARAMNGSDPDGYQMLLDDIDAIAVQLKRLQDADVPVLWRPLHEASGGWFWWGASGADAYLQLYKLMYERLTNVHGLNNLIWVWNGQDAAWYPGDEYVDIIGEDIYPGKHVYTSQAARFIKALSYTDTRKLITLSENGCIPDPEQLVRDNIMWSYWCVWEGEFVLKAAGFNNYSEQYTEKNMLKKAYKSDTVITRKELPDLRNYPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDI0</accession>
    <name>R7IDI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000154">
        <property type="protein sequence ID" value="CDE49869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49869">
        <property type="protein sequence ID" value="CDE49869"/>
        <property type="gene ID" value="BN770_02175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="390" mass="43580" checksum="4841CFDC14EFAB43" modified="2013-07-24" version="1">MKELELKYGCNPNQKPSRIYMEQGELPLTVLNGKPGYINFLDALNGWQLVSELKRATGLPAATSFKHVSPAGAAVGLPLNDTLRKIYFVGEQELSPLACAYARARGADRMSSFGDWIALSDVCDESTARLIKPEVSDGIIAPGYTDEALALLKMKKKGNYNIVQIDPSYRPAPIEHKQVFGITFEQGRNEFVIDENLLNDIVTTNHDLPEDAKRDLIVALIVLKYTQSNSVCYAKDGQAIGIGAGQQSRIHCTRLAGQKADNWLLRQHPRVLALPFVEKIARADRDNTIDVFISDEPDEVLADGRWQRFFTERPEPLTKEEKRAWLNQQTGVALGSDAFFPFGDNIERAHRSGVTYVAQPGGSIRDDNVIDACNLYNMVMCFTHMRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDI1</accession>
    <name>R7IDI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000144">
        <property type="protein sequence ID" value="CDE49501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49501">
        <property type="protein sequence ID" value="CDE49501"/>
        <property type="gene ID" value="BN770_02029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="152" mass="17096" checksum="D3D7288CD9FEAFA3" modified="2013-07-24" version="1">MDITERKITKIARETEKLVLLSLREEGVGTAEIDLIHALRHHPGCTQAALAELLHADKAAIARRTKNLEAKGFLVRQDDPNDRRSQLLYPTEKAEAMKASKAEIEASFYEYLTSVLTDDESKTFAVLLNKLYAASKTESRAGFPHFIQAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDQ7</accession>
    <name>R7IDQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49453">
        <property type="protein sequence ID" value="CDE49453"/>
        <property type="gene ID" value="BN770_02026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="314" mass="34636" checksum="37D509B502155B26" modified="2013-07-24" version="1">MSEAKREPLFHISKRTDISWQKALLIRVIAIALALGASAIICLLLTDDDPLAIYSTIIKGTFGTPRKTWVTFRDVAMLLCISLAVTPAFKMRFWNIGGEGQTLMGCLASASCMILLRDVLPNWALILVMLLTSMLAGAIWGGIPALFKAKWNTNETLFTLMMNYVATQLVAYFCIFWESPKGSGKIGIINQRSQIGWLPKVADQQYLLNIIVVGVLVLLMFLYLYYTKHGYEISVVGESQRTARYVGIKVEWVIIRTMLISGAICGLAGLPLNAGNDQSLTTLPADRGQRPHADDDACRRTRLHGGHGVMAGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDU6</accession>
    <name>R7IDU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49775">
        <property type="protein sequence ID" value="CDE49775"/>
        <property type="gene ID" value="BN770_02128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="266" mass="28790" checksum="CB9CF7E2F00286CA" modified="2013-07-24" version="1">MKPVIRAIAFDLDDTLLRDDRTISDETVSVLRRASEAGILILPASGRTYCSMAGFAKRIGCASRVICANGAVIAQPDGTTLHELTIPADIARQVALFAKERGCYCQTYAGDCFYYNQQGDYARAYAESSSLRGVYVGDLEQHLSAPTTKLLMMAPPEQVVQMLAEAQAQFGESVALTCSKPYFLEVNPPLATKGHALSVCAEEMGFPLSQCMAFGDSLNDVSMLRAAGHGVCMGNGREDVKRMGFAVCGTNQEDGVARYIQRILFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDU8</accession>
    <name>R7IDU8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000144">
        <property type="protein sequence ID" value="CDE49503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49503">
        <property type="protein sequence ID" value="CDE49503"/>
        <property type="gene ID" value="BN770_02031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="340"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="562" mass="60360" checksum="B5ACD39985287CA1" modified="2013-07-24" version="1">MRNQKKAGVISVLKAAVRSHRILTISTLLCVAASVAASLIPPLLLKNIIDRLTGGMPLLFTAVLLYFGSLVLEGTLSSAQETLLVLFGQKMTHALRSEMSQKLIALPASTLVGQNPGEVAARFSGDVDAVEALFTSGIISMVADACRIVSILAVIAVENTGLALVLLVILPLFAVFTRFVQKRMLAAQLENRRAVAAVSGQVPETLHNIRTIHALGLESYMEQRYDQRIGESYAAMEKTNFYDAIYSPVVFLLNAAVVGIVMLLSASGNADVLALFGMSVGTSVAIINYISRIFSPIESLGMEIQIIQSAMAGVKRIDEFLNQPERAISQERKNTARGDVVLSHVTFGYGEKPVLSDFSMSVKEGEQVTLVGRTGAGKSTVFRLLLGLYPPEKGDITISGVNVSAITDHERRACIGCVEQRFSRVPGTVLDQITLSDPTITEEMAQNAAKLAGMDDAIRALPDGYNAICTDGMFSQGEWQLLSIARAVAANPAVLLLDEITANLDAETEARVLEALRRASEGRTVLSISHRIYENLGGRTVEIKPYNAYAADSAADCSVKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDV5</accession>
    <name>R7IDV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EBSC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49790">
        <property type="protein sequence ID" value="CDE49790"/>
        <property type="gene ID" value="BN770_02139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="157" mass="16775" checksum="4EFB39F1A38A60EB" modified="2013-07-24" version="1">MSIEKVRAAFAAQGIADRIRELDESSATVALAAQALGCGPGRIAKTLSFQGKEQPILVVAAGDGKIDNHRFKERFGVKAKMLAAEEVPEKIGHAVGGVCPFAVNEGVEVYLDDSLRRFETVFPACGSSNSAIDTISKFTCAICSRLFRACVRSFHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDW1</accession>
    <name>R7IDW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000148">
        <property type="protein sequence ID" value="CDE49631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49631">
        <property type="protein sequence ID" value="CDE49631"/>
        <property type="gene ID" value="BN770_02061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="209" mass="22800" checksum="26754C231E6AA0FF" modified="2013-07-24" version="1">MIALANVVVQTNINDFGALAQAGCGAYSKIEGFGFLPITSFTLALTTFIGQNPGAQEYERAKKGARFGLIACVSIAEAIGLAIYAFIPALIAMFIQSGDAAQVQEVIRLGTMHARIMTPFYFLLALSNAMAAVLRGAGRSIVPMIVMLCCWCVFRVTYITIAVPIRPELTTISWAYPITWGLSSIIFLIYYNVVDWVHAYGRSKPRKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDZ4</accession>
    <name>R7IDZ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LytR_cpsA_psr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50049">
        <property type="protein sequence ID" value="CDE50049"/>
        <property type="gene ID" value="BN770_02250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436451" description="LytR_cpsA_psr domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="79"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="358" mass="40052" checksum="0BAC2DD1B752F55D" modified="2013-07-24" version="1">MALRKKMVCLLAMALALLMLCGTAMADNFSFLPSRTENGKEYLAHPSSELTTILLIGYDHYANGQIEEEPSQYHLGGQSDFLLLLVIDHKNQQIHQLQFDRDTMTPIKLVATNGKDAGTRRLQLCLAHAYGRTREENNQNTIWAVEKLLGIEKADDGAEIDYYISMDISGINKLNELVGGVTVTVPNDDLLALDPTLKGGETIKLTGMQAEYFTRTRYDTAEPTNEARMARQRIYLNSLETLLEEKIRANVNYVNTLLNEMGMIFDRTTTLDSGFGFTTDDATGTAITDTTDHYLMANVSIDNLALLANRVMDYEVLDVETLNGVHSLGSDEHIHFDLYENEALNWTLKTFYTEAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE88</accession>
    <name>R7IE88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar transferases involved in lipopolysaccharide synthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49940">
        <property type="protein sequence ID" value="CDE49940"/>
        <property type="gene ID" value="BN770_02201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="28"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="225" mass="25438" checksum="79BD8CDFA71D60F7" modified="2013-07-24" version="1">MQHGLPEQAIEPTASRTGANKLGYRAVKRAFDLTATAMAVIVLSPLFLILSVIVYLGDPGAVIYGQVRIGKNGKPFKMWKFRSMYRNADQMIDQLSEEQKRQYHTEFKIDNDPRITPVGNFLRKTSLDELPQLFNVLAGEMSLVGPRPLLKSEIQQYYADSADVLLSVKPGVTGYWQAYARNNATYQSGHRQQMEMTYIRQASIWLDCKILLKTVVAVLHRDGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEJ1</accession>
    <name>R7IEJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49841">
        <property type="protein sequence ID" value="CDE49841"/>
        <property type="gene ID" value="BN770_02159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="347" mass="39968" checksum="7D02DE2819787915" modified="2013-07-24" version="1">MLREFDLQRMHWADKTQSMLHQRQMEACETRLLSYPTESIFTLQDERETECWWQCSYDAEESPKSSVLHTLREMRANVLARLPVEAALLTETEHALIVRLILCGGQVRIDGWQELSAAESLLRRLWCTLEVDEQDVLLHLPRELMTPLSLTLREQRHQDLRSRLLFFDTDTKAALYLSGMLSAKQALSRLYESVLHDSYANDEALALRYLKAGNDFYYNRAGELFLLHPGLADPEKILREGGFPMGYQPDLPSERALMASRDLLPEEFETDAQLSALLDSCMGLETAEESSAHDLRILVKQHVTWSELMEVVRAMLPIPPTKELTACLHRLYAFTPRWGTYRAALVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEQ3</accession>
    <name>R7IEQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49798">
        <property type="protein sequence ID" value="CDE49798"/>
        <property type="gene ID" value="BN770_02146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014198">
        <property type="entry name" value="Spore_III_AB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09548">
        <property type="entry name" value="Spore_III_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="163" mass="18125" checksum="D077A5892E63A8FA" modified="2013-07-24" version="1">MTRLLFPICAALLSTLAGLHLSTHLRQEEQRLARWGEVLPHLHLLMASCAYSLPEAFRLCADGNHPPDTLLRQLADALERAPLSSPGALTDRLCPAISEKDIISRMMHLLSRGSLESRLLAVENARQEVTLMHEKAARKADKDARLYQTLGWIGGLCLLLILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IER2</accession>
    <name>R7IER2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49931">
        <property type="protein sequence ID" value="CDE49931"/>
        <property type="gene ID" value="BN770_02192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007516">
        <property type="entry name" value="Co_F420_Hydgase/DH_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007525">
        <property type="entry name" value="FrhB_FdhB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04432">
        <property type="entry name" value="FrhB_FdhB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04422">
        <property type="entry name" value="FrhB_FdhB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="398" mass="44298" checksum="705E29784B4C9831" modified="2013-07-24" version="1">MLDFDLLKDCYGCGACVNVCPRGAVHMTQAADGSYIPEIDEARCIGCGRCDRVCIHQHADKNHTPLGKEGCYAAYQLDTQARKASASGGMFFPLAQEMLRQGGYVCGCVWNEQMDAVHIVSNKLEDVERMRSSKYVQSDIGNCLATVRGLLKAGMPVMFCGTPCQCAACAAVTGNPENLLLVALICEGAPTAGVWQRYRDAKAARYGEKIRNVNFRSKTPVGWTMPYFVLTTKSGKRHQEMSYRQNPYVLAMLQGLTYRQSCYHCEFKGDHGSADIVVGDLWKAGERLIQQSENQGISALIVNTQKGKDWVDKAASAWFMEEYPLERVCANNSMLVRAGKENAHRAQFFSQLDVTPIETNLNQYIVHENGIKLRVTQALVAVGLYKPLRNAVRKLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IER4</accession>
    <name>R7IER4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative endo-1 4-beta-xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000161">
        <property type="protein sequence ID" value="CDE50120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50120">
        <property type="protein sequence ID" value="CDE50120"/>
        <property type="gene ID" value="BN770_02288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="4">
        <location>
            <begin position="161"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="491" mass="55446" checksum="F9150469A1DB2051" modified="2013-07-24" version="1">MKTVKIRLDGLGGMPMDEKTLKSTYATGMDFEPDERRMTIDSEGIVSLQVTKEPYMIHVKMAVPLYGYLWVMADNQGEGYTGEFVDFVTEAVRTYIHHAQKYAAGITLSPTTQGHLDAAIELQHLANRGQDTPDNRLYALSNAIYAAEGALVESARAKAFAAPRSDLKLGCNFARYTSDASRYAKFFAQAFDFATIPFYPRTTVPEKDCYDYSYVDHALSFLLDKGITPKGHPLWFGHQDVNPKWLFGLPYPELRREAANIARRHVSTYRDTIQYWDAMNEAHDWANCFELTQEQLIDLTRATTDALREGNDKAVSIVNVCLPFAEYVAGRYNCYGALPEHLRSPLSYFKAIIEAGIDFDVVGIQLYFPGRDLVAVDLLLNAFAALGKPIHITEMGVNGGFRQKGNAGSSWSQMAMSEGTWHGGWNEHTQADWLEQFYTIAASRKEIQALTWWDFIEPSFSGNGAMLYENENPRESYFRLLALKNRIIRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF18</accession>
    <name>R7IF18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S26A signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50046">
        <property type="protein sequence ID" value="CDE50046"/>
        <property type="gene ID" value="BN770_02247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="99"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="208" mass="24055" checksum="0C96BFB097F75899" modified="2013-07-24" version="1">MKTRMLTIRGIAVQITERENCRRFILRSRPDCPYAMLSVPKRSREADIRRFLENQQEWLQAHVGAVKNPPTFAPGEVHRLMGAWVTLGKDVPSGAAFVEMRNERLIREIERDIAKWASTLHVSITHVTLREMTSRWGSCRKQTQRLTFNTRLGGADESMIEYVVVHELCHLIYADHSVRFWALVASCLPDCKQRQIALNRMDMTPKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF39</accession>
    <name>R7IF39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50419">
        <property type="protein sequence ID" value="CDE50419"/>
        <property type="gene ID" value="BN770_02378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448227" evidence="4">
        <location>
            <begin position="24"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="134"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="734" mass="76396" checksum="F5FA4091E798F393" modified="2013-07-24" version="1">MKNTKRVLAFLVGAAMMLPMASAEGTLASGDYEATSQGFGGAVTVKVTVMDGKVTAATITGDKETEAIGGAAIKTLTEKLIGVSSADEVDAVASATVTSNAVKAALADCLRQAAGEEKAETALVDGVYTGDGSGFNLTQKVQVTVEIKDGKIASVTVGDNGETMGMIAAVEDKWIPRVVENQSLAVDAICGATASSNGVRAAVVNALESAGMDVSGMYKAIPKVNAAEEYNVDIVVVGMGSSGTTAALAAAESGANVLAIDKAGKWGGTGVTTSGPANVNAPSQVASEIVDWKDPINGVHTKAAGEQLVDADALYATWTDYTTVDGAQGAKPELIAKVIYESGETCDWLQSYGFEFTPAVGFVGGKWAIFSSYVGQKQLTESFFAKAYDRYTEMGGQYLLETEATELIMQDGKAVGVRAIKADGTSVTINAKAVILCTGGFAGSDEMQEKYIGQAYKLFGMSTNDGKMIESAIENGAATRAIGMYPMSHFVAPTVITTQFSAADNDIPYGLVCTAEGMAVNMKGERFINESSIAMNAFYQGNHFYYVYSKEQIDILRAQGLSANASGRYLTQGGIKADVPLTNIDTVIDAGIEAGFIYKASSLDELAAQIGGDFSADALKASVAGYNPENDAFGKDASKFERLGTVAADSEYYVAFTGAPYIYSTCGGLDVNENLQVLDTNGNVIPGLFACGTDSMGVLFNEDKAYTNYGGCAQSYCFVSGRDAGAYAAAHLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFA8</accession>
    <name>R7IFA8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="10" type="ORF">BN770_02420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50499">
        <property type="protein sequence ID" value="CDE50499"/>
        <property type="gene ID" value="BN770_02420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="155"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="413" mass="45725" checksum="A7D37415A5412AB7" modified="2013-07-24" version="1">MRKTKTTAAPKADPQNKELVEAIRALCQEKDLSEDMLFATVEDALKKAYAKNRAKGEAEPSANNISATIDRATGEIHVYTRRLIVEEVEKPADQISLEEARAIKDSYQMGDIVETDVTPRNFLRVAAQTAKGVIMQRLRDAERGRVYEEYADKENEILTAVVTRVDDKGAVVELMGRTEGYLERDQMIPGEAINMGDHLKVYVLEVQRGDDTTRRGPQVRVSRTHPNLVKRLFEMEVPEIAGGKVLIKGIAREAGSRTKMAVHSTEVLIDPVGACVGQRGDRVTRVVDELRGEKIDIIKWSENPAEFIANALNPANVREVYTEASGQRSCIVVVPDNQLSLAIGKEGQNARLAAKLTGWKIDIKSQSQYAEQMAAAVPQVEDEEQPAQELPEDFQPYEGVEAPETSADGDDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFG1</accession>
    <name>R7IFG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000163">
        <property type="protein sequence ID" value="CDE50191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50191">
        <property type="protein sequence ID" value="CDE50191"/>
        <property type="gene ID" value="BN770_02317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="198" mass="22071" checksum="82DB8C01FA73E434" modified="2013-07-24" version="1">MGVVASPVLLHLHVVAVLAVLHLNVDARRAVDGVRAIHHAFDAGSSHELLQPTLRNRAEVAIVETVRVSLRMCFGIVRSRNDVEDDQRAILQHEVVRFDCMRFRQHVRDVRVEGTLVQLRRIVLVSNHTALIRVDLTIFAANRLELVGCRVPCVEGELRSRQQQRGVRAVHLADDQIVVDVAAALTEVVVIAIVQFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFK2</accession>
    <name>R7IFK2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50113">
        <property type="protein sequence ID" value="CDE50113"/>
        <property type="gene ID" value="BN770_02286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="599"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="743"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="999" mass="111614" checksum="6CE2C69F3E559E01" modified="2013-07-24" version="1">MAPAPQSRKMHSVFFTIFFSLLLVLVIELTLLIGTIIVGQVPSQLDDNAEEVLCEQVENRSGYLQNFLVSSQELTALSTYINSQTEALLADGTISLDTLDSGSAASEPLLRAISSELVFEMRAKKLSGIYVIFCSRDLDDCADGTRFPGIYVRDLDPDGPYSDRNADLSLEFAPATLVQSTGLYTASAWQPAFEYQREASDFLYLPYQTARNAKTLLSADDYGHWTRFPFCLPDDPRSVFSYSQPLILPDGTVYGVVGIGLLSGTYLRGMLPTYELQNEGSGSYLLCSTTDDLSADTLTLQIAVCSSSDTAIHAGNTLVLQKDASGEGFLTIDGTRYFASEQPLALYSRNAPFSGEHWLLIGLVPVKQLYSFSGSVRQMLVIIVVLTLLAGVFASFIVSRRLAQPITRLSKQISASQNQRYQVPTLSPTGICELDQFSAAFTQRSQEILDTSVKFQRIMELASVEIGGFEKRPDVDTVYVTDNFFSLLALPDVPLDSLNKDWFDAILNGWKQTHEYVTRAYGGEVYALPASGGTVRYILLRSGEERGTQVGLVEDVTTSMQERRRIEHERDYDVLTGLYNRFSFMRKVQEMFAHPDKMRHAALLMTDLDDLKRINDTYGHDCGDRYIRLTGQCLAENIPANAVCSRLSGDEFVVLLHGYESRDALRADLTHLQEAMSTYTAVLPSGDTMHIAISGGVAWYPDDSRDFATLKRYADFALYQVKRQRKGEIREFDIGAYNREAYYAQLRQEFSALLENSSVFYHFQPLFSARDGHVVAYEALMRVNMPLLRSPETIMKLAHEENRLYDIEHLTLFKGTQTFERLVSCGKLSPDAKLFINSIANVSLTDADFADFRRQFAPMLKKMVIEITEEEETTPEVLAIKRRQFGKDAVFALDDYGSGYSNSNNLLLLAPHYIKVDIAIIRGIDSNIDKQQVVTDVVTYAHARQMQVVAEGIENEAELRTVLRLGVDLLQGYFLARPAAIPDPIAPAALKILKDAHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFS8</accession>
    <name>R7IFS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49432">
        <property type="protein sequence ID" value="CDE49432"/>
        <property type="gene ID" value="BN770_02012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="92" mass="10000" checksum="50C1022A2499AA17" modified="2013-07-24" version="1">MNKTELVAALAEKTQLPKKNAELALNAVVEVITESLSKGDKVQIVGFGSFEVKDRPERIARNPQKPEEEITIPASKAPVFKAGKSLKDAVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFU8</accession>
    <name>R7IFU8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L7Ae family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50495">
        <property type="protein sequence ID" value="CDE50495"/>
        <property type="gene ID" value="BN770_02419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00279">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="98" mass="11112" checksum="D63B239EE9EAE4D4" modified="2013-07-24" version="1">MKPKKIPMRMCVGCRESKPKRELIRVVRAPDGTVSMDPGGKKPGRGAYVCRQESCLMRAIRQKQLERQLEVQLTDDVAEALRQELAQLSQSQTEAEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG08</accession>
    <name>R7IG08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000145">
        <property type="protein sequence ID" value="CDE49522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49522">
        <property type="protein sequence ID" value="CDE49522"/>
        <property type="gene ID" value="BN770_02039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="56" mass="6342" checksum="17FB3F60BDCCA0AA" modified="2013-07-24" version="1">MAKQCVLYDRECIDCGECQRCDLDPDKICDNCMKCVMGDADYRAISITGIELEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG72</accession>
    <name>R7IG72_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50461">
        <property type="protein sequence ID" value="CDE50461"/>
        <property type="gene ID" value="BN770_02403"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="183" mass="20075" checksum="ABF3382E495F3636" modified="2013-07-24" version="1">MNTPTRKTLAVLVDNEAGVLSRVVRLFSGKGYNIESLAVGTTDDPAISRITIEILASEEQTHLISSQLRKLICVHSVKTLNAEHAIRRELVLIKVSAATSETRNEVIQIANIFRASIIDVSVASLTLAVIGDESKAEAIQNLLREFGILELVRTGMVALERGQFTIDEQTKVKGEYDYGKNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGZ8</accession>
    <name>R7IGZ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50608">
        <property type="protein sequence ID" value="CDE50608"/>
        <property type="gene ID" value="BN770_02456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435928" evidence="1">
        <location>
            <begin position="22"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="371" mass="40498" checksum="15002DFC4A62277F" modified="2013-07-24" version="1">MKKRIFALLLAAMLPLGAAIADEPLTDGTVLVDWVDGQEAYTAICSGELTLRYDADTNTYATADGLIWKTEGALPFATYQPLLMPRTREELLQCNAIYAALQDASGFWSEKVTGTEVLPVYAAPDENSYRASNGKASVSLAGGATLLMQYGDWSLVRYEVNSSRMRIGWVHTNQLGSAPVMLTDIPVTLKAGAFLTDDPIASWYHTAEGNTLTDVRLLAQYDPFWAYARATMRDGTMLWGFVPLMSVQLNDTVDAEAMANISGTWGFCGGGELMGWVFTLMADGQGVCYAISDEASESMRYLTEGITADMNPESAGMFQWQIVGGTNGYAHDFILSNTSNGTYERYHAALTEDGHLGFYQCEAGGHYQRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH26</accession>
    <name>R7IH26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation integral membrane protein YlbJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000177">
        <property type="protein sequence ID" value="CDE50731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50731">
        <property type="protein sequence ID" value="CDE50731"/>
        <property type="gene ID" value="BN770_00193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436613" evidence="2">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="281" mass="29446" checksum="D0F605469875ACD3" modified="2013-07-24" version="1">MRILLAGMMALLLLRAPETMAAAEAACALFVRSVMPGLFPYLTLSQMLVSRCGRDMQPGLLMLLGWCGGSPTGARLLAMQGSRPHREQKALAVSCATMSPMFLLGTIGSWLNSRIAGAIVLLSVLAGGCCAGRLAKRWTRVTSAEKVPEAAMSPVSFARAVEDSARTMLLVCGTMTMLRVLATLTDFLPDAMRLPLTTLLEVTTGAVTIANLPAPLPLRIALLSAATGFGGCAVIMQNRALYPQGLMRLGEQLAWQALHGVISGALALGIALLVLSAGGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH51</accession>
    <name>R7IH51_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="10" type="ORF">BN770_00251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50945">
        <property type="protein sequence ID" value="CDE50945"/>
        <property type="gene ID" value="BN770_00251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="273"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="641" mass="72237" checksum="F730705C73F06840" modified="2013-07-24" version="1">MSGFRLLLSKGEFFMAKIDWGEKLELKIRMLPESPGCYLMKDKDGTIIYVGKAVNLKNRVRSYFRDTEHTPKVAAMISHIDDFDILLCDSNLEALCLECNLIKLHKPYYNILLKDDKHYPYLRVNLKEPFPRLTLARRMEKDGAKYFGPYIGATAVRQVIDAVRGVFPLRTCRKELPLKTPCRPCVNYEIGKCLAPCAGKCTEEQYWDMMDGVLAFLGGDYKQVLDVLNREMMDYAAKMQYERAAVIRDKIRDVQGLMERQIAIQTDRSEQDILAIAQDGLDAMIQLVYVRGGRMVGGDHFALPREGSEPAGDVLAEFLTQYYQEGNLIPRNILVQELPDGAQAQLEQWLRQQKGAAVTLVTPRRGEKHDLVLLAAKNAHDALEKRNARASIREERTVGAAAALGRALGLPKAPRRIEGYDISNTQGVLSVASMVVFIDGEPAKKEYRRFRIKTVEGANDFASLNEVLGRRFAHGLQEKAEREEQGLSPIGGKFSDLPDLVLIDGGPQQLRFARQALLDMGADVAMFGLAKKQEEIFLPDREDPICLDHHTPELHLIQRVRDEAHRFCITHHRGLRGKASIHSQLEDIPGIGPKRRKALLTKLGSMKAIREATEEELLKVPGMNQAAAKAVRKWAEAQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHD9</accession>
    <name>R7IHD9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fumarate reductase/succinate dehydrogenase flavoprotein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000180">
        <property type="protein sequence ID" value="CDE50861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50861">
        <property type="protein sequence ID" value="CDE50861"/>
        <property type="gene ID" value="BN770_00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436622" evidence="1">
        <location>
            <begin position="24"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="383" mass="40516" checksum="23F60C6498E6220D" modified="2013-07-24" version="1">MKRRALSTLMALSLFCAGGAAMADGAYTPGTYTVSADGNNGAITLRVEMTADAIADIKVVSQSETAGLGDVAIDKMIEAILVAGNTDVDTVSQATVSSEAVIAAVNAALSRAEKGEVDTVASPVAEAVTEETFADQCKAAGIDFTYEDPNASIYDFQTTDAAVDVITHASGKAKYVDETDGPCIRTPLDLAARSAVKVKVYYWIADENGVSTLEEAAKLENAQYVSVPFPNDGGKYAIKLQSNGLGTNTVVTIDENNEPTVAIFGLKYTVDENGTDVYTSCAVMAETATYRNLIAGSPIVISYYEYNPFTEKKIGIGARNAGARVQCELDQQRSMLTTIPAEGETAQKISVADYLAMDEDARNAIQIKYITMVAKVVALYSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHU7</accession>
    <name>R7IHU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50162">
        <property type="protein sequence ID" value="CDE50162"/>
        <property type="gene ID" value="BN770_02306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="75"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="34664" checksum="C226B6E803530F68" modified="2013-07-24" version="1">MRKSWLFPGDNDEPYVSQRAGAYQPQSEKRRRWTKRLVILALILCVLYPFVEPYTLRTTQTAITCEDLPASIGQLRIVYVSDIHYGTQMFSDARLSSLINRINALNADIVLLGGDYARDKWSAAAFFENLPRRISSNYGVYAVVGECDRSPLEKGEEPSTLRNKMSKAGVTLLCNEVATLRIGTSDIYIAGIDDVSTEMDDAKSVAAQVNSKDFVIFLAHNPSAISSSLLLTDRNGRGNWFDLGLFGHTHGGQIPFLEEAFNFNGVPSRYESGLLLENRSWLLISRGVGTTGFPARLFCQPEIHLITVQSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7II73</accession>
    <name>R7II73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thermostable beta-glucosidase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51305">
        <property type="protein sequence ID" value="CDE51305"/>
        <property type="gene ID" value="BN770_00372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="110" mass="12027" checksum="0DE4309198C402CE" modified="2013-07-24" version="1">MWATATPPPQRRKSASPSASISLSGGKVIRPARELKGFARVHLEAGKEKAVTITFDEYTFRYFNVQTNKFEVEGGAYDILIAASSEDIRLRGTLEVRTPSAAWSPSSPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIA1</accession>
    <name>R7IIA1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50297">
        <property type="protein sequence ID" value="CDE50297"/>
        <property type="gene ID" value="BN770_02354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="59"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="260" mass="28606" checksum="B4F1DA5BF90EA4C8" modified="2013-07-24" version="1">MREGKKHPFAINVWRWGLLILLLVLWEIGARLKWIDPFFFSSPLEIARTAVIKWQGGTLWRDIAYTGASTLLGFVLGTVIGSIVGLLFWFSRPVAQVAEPWMIVLNALPKLALAPVLVIWFGIGFLSKVILAFLMTVVVAAMSAYSGVRTADSALETLMVSLGARRMQIFTRLIVPSAMPSIITGLRVNIALAMAGSIVGEFIASDRGLGRMIVYAGTTFDLKLVWVGVTVLSILSVLMYASVVLLEKVLMRHWRGTVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIP7</accession>
    <name>R7IIP7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsU</name>
        <name evidence="7" type="ORF">BN770_00042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000213">
        <property type="protein sequence ID" value="CDE51331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51331">
        <property type="protein sequence ID" value="CDE51331"/>
        <property type="gene ID" value="BN770_00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="57" mass="6890" checksum="34DEBA4E38ED9F66" modified="2013-07-24" version="1">MSEVRVRENESLESALKRFKRQCARSGVIQEVRKREHYEKPSVKRKKKAEAARKRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIQ7</accession>
    <name>R7IIQ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51515">
        <property type="protein sequence ID" value="CDE51515"/>
        <property type="gene ID" value="BN770_00470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="209"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="271"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="488" mass="53000" checksum="A00884AE32A82EA5" modified="2013-07-24" version="1">MFGRIMAVVVAVIVLLTSVLSGLGLYTLTSRQTAIRQENLRAEAREIAYLASLYSGGSSTYTLGTSLFSGSAQNTVALKHLRWKAAQVYDEYGAYIAIVDRSGQVMDNMAVTYEKNPDFAKTLNGKDIYEALLTIIGGDEISIRRQVDGDWYFTVGVPFVSGGLVRGAVFIQTPAQEIEVRAGTLLLPVLGVVLGFCILAGGALLLYLRRILHPVSVLSGAAKAMSEGNFSVRAPEGKATCPEIAELSASFNTMAEKLSQLEESRREFVANVSHELRSPITAISGYVEGMRDGTIGQEDYPQYLTIVSDETTRLKNLIGDLLKLSRLEKADAALNKTNFDICELLSRVLLHRTGDLEAKKMDVECDFAPEPCMVNADESRIEQVAVNLLDNAIKFTPDGGVIRMSVRVNQGICTVIVQDNGVGISPEDRPHVFERFYTADKAHTSGKGTGLGLSICQRIMEMHGQKITLMDTGDEAGAAFAFTLDCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ16</accession>
    <name>R7IJ16_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 13">L-threonine dehydratase catabolic TdcB</fullName>
            <ecNumber evidence="7 13">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BN770_00594</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 13">In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="7 13"/>
    <dbReference type="EMBL" id="CBJB010000241">
        <property type="protein sequence ID" value="CDE51739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51739">
        <property type="protein sequence ID" value="CDE51739"/>
        <property type="gene ID" value="BN770_00594"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00052">
        <property type="reaction ID" value="UER00507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070689">
        <property type="term" value="P:L-threonine catabolic process to propionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="325"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE51739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="398" mass="42358" checksum="B1A239113FD1FA56" modified="2013-07-24" version="1">MLTLDKIYHAAYVLKPVARKTDVIYAAKLSQGYDLYLKTENLQLTGSFKLRGAYYKISQLNEEQRKAGIIACSAGNHAQGVALAASRMGIKAIVCMPDGAPISKVEATKALGAEVCLVKGAYDDAYNYACQLQQETGMTFIHPFNDEEVIAGQGTIGLEILDQLPDVDAVVCSIGGGGLISGVACAIKSLNPKVKVYGVQAENAPSMKRSLEAGEAITLDSVRTFADGIAVKHPGDITLDMVRKYVDEVVTVSEDEIAAAILALMEKQKLVAEGAGAVTVAAAMFGKLPIAGKKVCCLISGGNIDVNILSRVITRGLQREGRNCLLTIALDDKPGQLLGVTQVISECGANIVGVTHERSDAAYAVTSCLLRISMETRDFAQIEEIKAKLTEQGFKLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ88</accession>
    <name>R7IJ88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51690">
        <property type="protein sequence ID" value="CDE51690"/>
        <property type="gene ID" value="BN770_00569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="161" mass="18649" checksum="686CD3DE83655EC9" modified="2013-07-24" version="1">MTIVIQLVLYCFLLWLIVKVVVGNNAINGLYFYPKAFQECAISRGLIDRATVQKKRRNCMIALYVLLLVAPVLMIGVWNRVTDFWTAYGQGVLFLEVMNWFDGLVIDMLWVGHSKFWAIPKMEDMRYTQTWGQMLKKRLTLTVIWLVGAFIIAGLVMLMPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJB4</accession>
    <name>R7IJB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51393">
        <property type="protein sequence ID" value="CDE51393"/>
        <property type="gene ID" value="BN770_00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="119" mass="14046" checksum="176ED1D49440DAA6" modified="2013-07-24" version="1">MAKKPIDMKKNLRNIWLDMNFLQDIACSKEENKQFRQMKKNGEALPEGVREYQDVNGFVTGEFFRIYDAGLTENERIEYTFYGMLQQLRTIKKCCVFFTTLTVISLIIGFLFWVGVFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJG4</accession>
    <name>R7IJG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51626">
        <property type="protein sequence ID" value="CDE51626"/>
        <property type="gene ID" value="BN770_00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="176" mass="20275" checksum="2D90601504EA767A" modified="2013-07-24" version="1">MDRQDEQTAKPYQSTHCRRTTYRRSRQKNNALTKGIRGQKYHRRAHENRRTCDDRRVSERMHPPQSGKSTEKANQQTRCPSALTGQTAEAPRKPHENGENPQALESNQASIENSTGAVGKTFRTRHSRSLPILQSNNASVKGKRRVLCRMQKVYFAGLDKPRAIRYNQGRRFLMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJK6</accession>
    <name>R7IJK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51790">
        <property type="protein sequence ID" value="CDE51790"/>
        <property type="gene ID" value="BN770_00617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="261" mass="29807" checksum="6F0D65B10D4F4F20" modified="2013-07-24" version="1">MSKKGLKENQIFAARDTVEENDKIKAAREAVAADPTNAEKYMALGLALRGQMFFREAVEAYSIGLTYNPFMSLLYRHRGHAYVNLGQYQEAAADFEMGLRIDPKNWDCWYHLGLSYHLMGSYERALKAYETCYALSPTDEYRICTTDWYCMTLMKMGRIDDMRKAASRIHADMEPGMSEGYFDRVLVYNGTRNIDEVLAEAAAKDDHMYATGAYGLAVYEEYVLGNREKAKEILTRIAGRDETWGGFAEHAAADQLKHWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJM4</accession>
    <name>R7IJM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51810">
        <property type="protein sequence ID" value="CDE51810"/>
        <property type="gene ID" value="BN770_00622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448348" evidence="2">
        <location>
            <begin position="24"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR019574-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="347" mass="40125" checksum="1F8DEE08CCD77333" modified="2013-07-24" version="1">MKKLLSLLMLLCLTLTVAPAALAEEVVNVYNWEDYIAPEVLTLFTEETGIKVNYMCFTTNEDMIVQVEANPGAFDVCFPSDYIIERMIAKDLLAEINYDNVPNFEQIIDKLRNPDYDPENKYSVPYMWGTVGILYNKDMIPEPNQSWSILWDTQYQKNVFMLDSYRDSMGITLKYLGYSMNSREVPELMAAKDKLIEQKQSGVVKAYQVDETKDKMVAGEAALALMWSGDAQYAIDLNDHLDYFVPSEGSNIWVDGAVILKSARNKENAEKFINFLCRPDIAQMNCEYIWYSSPNKGAIELMGEEYENNHVLNPSQEVQDRCEFFHDIDDTFRKIYENLWMEIKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJP1</accession>
    <name>R7IJP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51830">
        <property type="protein sequence ID" value="CDE51830"/>
        <property type="gene ID" value="BN770_00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="62"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="512" mass="57462" checksum="E1F55C08D772FC64" modified="2013-07-24" version="1">MAILCLPVLSAQASPTSDALVIGIQSSKTTSLNPLFPVERDMLSIFDLMYDSLITIDDNYQPQAGLAESWTQTGNGRTWTFTLRQGVLFSDGTEMTANDVVATANYIISCAKDTNLTNKGYYANLRYFVKEIKARDNYTVEVRADRQYYGVLYAMTFPVLPASALESANPPGTGAYMITAFTPYSNGTKGSMTLSLNPYYSGKPPQFKNLYFDLYGKDADVVNAYQYSNVDAIFSRSLSIAQYKSSTNTLAITYRTNQLECLLLNNYLGSMTNNMRTAIRSCINIDSIVQSVYMSMVDRTNTPMIQGTWMYNSNLSSYFQVDLNKARQLLEEDGWYDTDGSGYVDKPNKNNEAADLTYNIITYEEPDNSVRVQAANMIADMLGQIGIKATVETVSYSTMQERLKAGNFHIALVSFAMDVCPDPGFLLMSGNTCNYVAYRSKTMDALFKKLRTQVTQADYQSVLYDIQEQFAKDCPFICLYYRGGTVLTRRMYTTTRDVREGHLLDGIESFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJQ9</accession>
    <name>R7IJQ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50817">
        <property type="protein sequence ID" value="CDE50817"/>
        <property type="gene ID" value="BN770_00216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="307" mass="34857" checksum="C56E6A25FDCDA723" modified="2013-07-24" version="1">METAKKQGSIKPRRMKAPKPFKKRIEPWLWLMPALVFFLVFTYYPFIKTVVSSFFVVNKMGVFKQFAGFDNYVRVLKDRSFQTAIQNTFIYVLLASPVSILIALLLALIAAKKRTMSVAYETLFAVTMAMSMSVSAMIFKLAYNPNIGILNYILGVKINWLNDKHYAMVAISIIATWMNVGYNFIFLLAAVRNIPQEILESCELDGARPFRRTVNIILPMISPTTFYLICTSLAKSMMMSGLVLIFTGGASLNTTANIDTMISYMYKQSVNNLNYNKGYAAAIIAFLMTFMVMLISFRFEKKGVHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJS4</accession>
    <name>R7IJS4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor G 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50837">
        <property type="protein sequence ID" value="CDE50837"/>
        <property type="gene ID" value="BN770_00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFG_IV" evidence="4">
        <location>
            <begin position="272"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="EFG_C" evidence="3">
        <location>
            <begin position="393"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="492" mass="54175" checksum="97DBCBE7897A0151" modified="2013-07-24" version="1">MECYSYLIEQAAAADEELMEKYFETGELTFEEIKAGFRKGMKDGSIVPVVAVSAATGVGIARMLDLMAKYFPSPAHNGLYWAGKDPRTGEDITRICKDDQPFSAFVYKTIADPFVGKLSLFRIFSGMLSGQTTLYNPGKDKTEKCGGIYILRGKKQVVKESLHAGDIGAMAKLQYTSTGDTLCDPANPVVYPPIEYPKPCISKAVYAAKQGEEDKVFSGLQRLMEEDPSVTLSKDPETMETLLSGQGEMHLDVIRSKLASKFGANCVLKDPKIPYRETIRKAVKVQGRHKKQTGGHGQFGDVWIEFSPVTDGSTDIVFEDAVVGGVVPRNFIPSVEKGLRECMVHGVLAGYPMVSVKAKLYDGSYHPVDSSEMAFKTAARIAYKKGCADANPVLLEPIMHVEVIVPDDYMGDVMGDMNKRRGRIIGMEQCEGGQKIIAEAPLSEMFKYATDLRSMTQAWGRFTMTFERYEEVPADVAKKVIASADKVVDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJX7</accession>
    <name>R7IJX7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_00698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51930">
        <property type="protein sequence ID" value="CDE51930"/>
        <property type="gene ID" value="BN770_00698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="9">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="7">
        <location>
            <begin position="162"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="8">
        <location>
            <begin position="261"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="10">
        <location>
            <begin position="576"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="11">
        <location>
            <begin position="651"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1140" mass="125907" checksum="D914F9BFFDAE4201" modified="2013-07-24" version="1">MEQLLNDGWQFCKLPLGSTLEDVSNAALQAVDLPHDFLIENENDLYETTDAWYLRTLDVPESWCASCVLVRFDGVYMDCDVLLNGHIVCTHHYGYTAFDVDLTSRLLVGRNTLAVHIRHQSPNSRWDSCRGNQPRNSRWYSGAGIYRDVTLHVLPKRHIPLDGVYVTTTHELESWTMTIDTELCGVKDNGVLTHVLLDGDVPVCDVTVEAAGDHANAVMQVLSPKLWSPDAPNVYTLQTMLGNQVIRQNVGFRDLTFTTDCGLLVNGAPVKLHGVCLHHDLGCLGSAFHEKAMRRQLRAMRQMGVNALRTSHNPPAKQVMDLCDELGIFVVDEAFDMWLRAKTPFDYARFFPTDMPSDVAAWVRRDRNHPSLLMWSIGNEILDTHLDESAQQVTCDLCENVRLHDPRGNAVITIGSNFMPWEGARKCADLVDAQGYNYGEKYYEAHHAEHPDWVIYGSETASALSSRGIYHFPMAASILSDEDLQCSALGNSTSSWGTKDMRKCIVEDLNTPYSLGQFLWSGIDYIGEPTPYHTRSCYFGMMDTAVFPKDYWYLFKSLWTNAPMVHIGVYWDWNPGQMIDVPVMTNGVKAELLLNGRSLGVQEVSRTDWTRCRPAWQVPFEAGELVARAYDADGHLIAEDIQRTPGESHHIVLSAEDAFLLGDGEDMTFVTITVADENGTPVENAVDRVLVDVDGCGRLLGLDNGDSTDRDGYKTNTRRLFSGKLLAIVGALAGEGTIRIRVSGVGLVGAELTLPVRAARKTPGRSCSAVLCRQEELPADKPVRRIELLPLGDKRLGSEHPTVSFRVAVHPADADKQPIAFRVTNGQGIDSPCASCSVDGDVVTVTALGDDTVYLRASCTNGYDHPRIISQQDIVITGLGQPFLDPYGFISGGLYSLSSGEIGNGNEQGISFARDGESMAGYTKIDFGDVGSDVITLPVFALDSNLYEIKLWDGDPADGGRLIAVLPYQKPSIWNVYQSETYHLPERLTGVHTLCFSLTSKIHLKGFSFEKQSRAWLPQTAQDADTVYGDSFTRSGSAVTSIGNNVSLVWENMDFGTSTHAELRLDGQTPLSTNPVTIRFTNQEGEQLTSLAQFSGTERGVQCFDVNVLPGVCSVAFVFLPGSQFDFYGFAFVKQEEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK02</accession>
    <name>R7IK02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51643">
        <property type="protein sequence ID" value="CDE51643"/>
        <property type="gene ID" value="BN770_00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005709523" evidence="3">
        <location>
            <begin position="30"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="502" mass="56305" checksum="81DA0DC9D0AE131A" modified="2013-07-24" version="1">MNRMVSRLCACLVAFSLFAALCGGMVARAADGFDYNYTYTYDYWGDERQSPDAYRTSAMLSSVSLGLETPMRTPRGLTVSGNDIYIVDTGNNRILQVARDGENFTLTRVISEISGDITPNTLSAPQDVFVMADGTLFIADTNNNRILKADRNLNLLSVFTRPTDATFDQSMAFLPTKLVCDTTGRVFCLAQNVNRGLMKYEADGTFTGFIGASEVKYTWYELVWRLLSTKEQRAQQASFVPTEYNNIALDSEGFFFVTTQTFNSNELISGAAKPVRRLNAIGTNILIENGTSHVIGDLQWARGDTNITNSGPSKFVDVTVLDNDIYSVMDKTHNRIFTYDKQGNLLWAFGGVGNMDGYFLNPVALEHQGYDLLVLDSQDCCVTVLTPTEYGKLVYKATEQYHAGEYAASADTWREVMKRNGNYDLAYIGIGRALLQQKQFKEACDYFAMARDSRNYSEAFRYYRSEWVEQNIGWIFGIVAVLLVVPMVVGHIRKIKWEVDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK47</accession>
    <name>R7IK47_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad nucleotide-binding protein 1 (Adenosine5'-monophosphoramidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51826">
        <property type="protein sequence ID" value="CDE51826"/>
        <property type="gene ID" value="BN770_00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12362" checksum="B97710F7C9F29A40" modified="2013-07-24" version="1">MENCLFCKIIAGDIPSTKVYEDDKTYAFRDINPMAPVHVLVVPKTHVASLDAVDALSDELLAACLRTCRTVAHQEGIAESGFRVVSNCGCDACQSVQHLHFHVLGGKKMAESMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK99</accession>
    <name>R7IK99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51037">
        <property type="protein sequence ID" value="CDE51037"/>
        <property type="gene ID" value="BN770_00272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="33" mass="3501" checksum="AE83137A66A01C60" modified="2013-07-24" version="1">MDGGGQAIGTTVQLGGACMDKLRKMVYDSRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKG1</accession>
    <name>R7IKG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51778">
        <property type="protein sequence ID" value="CDE51778"/>
        <property type="gene ID" value="BN770_00605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="271" mass="30235" checksum="9B493C1B4579B52D" modified="2013-07-24" version="1">MDQAQWAQTEIALLPTEQIALRPSVQQKSLSHMPLETLAASMAREGLREPILVRAAAQGYIIVEGNRRLMACRMLGWREIPARVQPKDVSDMTSAGEIFAALRARPMGYLDRAEATNRLTADFGVPRAAIAQQTGDSAAHVLSLQRIATLDDRTRDILRQEQLPERVAEALTRVADAESRQRIALRTAKERLDIREVELFVEATNRRLPGAKHSGKVVSAVRDARPYLNALREVVAQMNEAGLPVRFDEAQEDGGTTLTIRCLTRRRRSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKQ5</accession>
    <name>R7IKQ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000200">
        <property type="protein sequence ID" value="CDE51192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51192">
        <property type="protein sequence ID" value="CDE51192"/>
        <property type="gene ID" value="BN770_00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="242" mass="26823" checksum="4B6736CA49C8E742" modified="2013-07-24" version="1">MVEARHITMDFRIDQNRTTNLKEFVVDTLRRQTHTTTFRALDDVSFIAEKGSVTGLIGHNGAGKSTLLKIISGIYPPTSGSVALQGTLVPMLELGSGFDAELTGRENIFLNGAILGYPKDFLHDKAPEIIAYSELDRFIDRPLKTYSSGMLARLAFSIATVVQPDILIVDEILAVGDERFQRKSRARMLELMSGGATVLFVSHNLSQIRELCDRVIWLEHGRIRAQGDAKSLCDAYEREAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILA6</accession>
    <name>R7ILA6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000218">
        <property type="protein sequence ID" value="CDE51407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51407">
        <property type="protein sequence ID" value="CDE51407"/>
        <property type="gene ID" value="BN770_00419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="197" mass="22739" checksum="1CCA08BF11029121" modified="2013-07-24" version="1">MSQTAVVTHQKAIRKDNPVMKVIGRVLLYTVLIAMALFTLIPFVWMLSSSLKLDQEVFQYPIRWIPETFHWENYRVIWERVSLLTYFKNTAIIALAVTFLQTLTSSFAAYAFAKLRFKGRDLLFVAYIATIAVPWQAYMLPQFIMMRSMGLYDTLLAMIVLQAFSAFGVFLMRQFYQGIPTELCEAARIDGLSEYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IM04</accession>
    <name>R7IM04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51657">
        <property type="protein sequence ID" value="CDE51657"/>
        <property type="gene ID" value="BN770_00558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="157" mass="18487" checksum="FA70F574D4CE393E" modified="2013-07-24" version="1">MKCINFDERFADFTAKWMKEHRGEYKTYDEMEDDLPRVYTEFLNMPAKWLDGVTPGAYFTQFEDAKDLVDWMVQYCQKDIPVPDMLMEQIQAVGRPCEKRLLTLLRDESDAIPEEARMTAIGLLRDMGSTLPKMLYIQWQLKREMKDDLAANALETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMA8</accession>
    <name>R7IMA8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000239">
        <property type="protein sequence ID" value="CDE51727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51727">
        <property type="protein sequence ID" value="CDE51727"/>
        <property type="gene ID" value="BN770_00587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="157" mass="18140" checksum="F521F894ED4879E2" modified="2013-07-24" version="1">MDDLKSDALRDMDVEIRLDATRRKPRFIIETAEMTPELTRLIQQLTARAAVPIIGYQQDKAFPLQQDSLVRVWAANGHVYAATETDEFLLRQRLWELEERLDSHHFIRISNSEIINLRRVIAFDLSLTGTICVSLQGGQISYVSRRYVRTIRQALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMQ7</accession>
    <name>R7IMQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA repair protein radA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51912">
        <property type="protein sequence ID" value="CDE51912"/>
        <property type="gene ID" value="BN770_00692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="3">
        <location>
            <begin position="68"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="253" mass="26908" checksum="E11E291781797036" modified="2013-07-24" version="1">MAKEKTLFACTACGYETSRWVGRCPGCGAWNTMVESAPIVTGAPAKAPKQRPGTGASAMLLREIPEDVAVRSSTGISELDRVLGGGIVEGALMLIGGDPGIGKSTLLLQVCANLCKTGKRVLYVSGEESAKQLKLRANRLGITSETLYVLAENALDNVEEKLRGLSPDVAVIDSIQTMYRPDMASAPGSVSQIRECTSQIMRLCKESGTAIFLVGHVTKDGAIAGPRMLEHMVDVVLYFEGDRQQEYTLLGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3I8</accession>
    <name>R7I3I8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46469">
        <property type="protein sequence ID" value="CDE46469"/>
        <property type="gene ID" value="BN770_00881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436122" evidence="1">
        <location>
            <begin position="32"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="259" mass="27865" checksum="8ACBC68B00FC8980" modified="2013-07-24" version="1">MQTSRKMKKRLLTMLTLCSCAVLLASCRASADTRTGQADGYGGILRVQVMMEDGAISAVNILEQHETDGIGSRALDILPDEMIRMNTWDVDVVTGATMTSNALREAVRVALNASDTMDEATGNPANRAGQAIREGIGMAATGRVGPGKDDEDGQVYSFNVVFAHGTFDEDGRIVSMAVDQLEVATPNYSGASMPQFSGFPGQGGYSLWDDSAGKVVGYTEDSEDNYMQEIAAWTSKRARGEDYQLTSGSWREQMDAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3K6</accession>
    <name>R7I3K6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxaC</name>
        <name evidence="7" type="ORF">BN770_00785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46210">
        <property type="protein sequence ID" value="CDE46210"/>
        <property type="gene ID" value="BN770_00785"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="469" mass="53618" checksum="D29923547E93E604" modified="2013-07-24" version="1">MTTFMDKDFLLNTETARKLYHDYAASCPIIDYHCHISPKEIWEDQRFENITKVWLGGDHYKWRLMRCAGVDEYYITGGASDYEKFCKWAEVVGKAIGNPLYHWTHLELQRFFGYHGTLSAKTADEVWNLANETLQKPGYTTRGLIAMSNVETICTTDDPVDTLEYHQKLLADKSFKTNVLPAWRPDKAVNIEKPDFMAYIAKLEKAAEMEIHTFADLKAALEKRMAYFHENNCRLSDHGLNYVVYEPADDAAIEAIFAKKAAGETLTDTEVAQFKTAMLLFCAAQYKKLNWTMQLHYGCRRDNNRVMFEKLGPDTGYDTINNYTPVDQMAAFLGAVESASGLPRTILYSLNPADDQAIDTLCGCFQSSEAVSKMQHGSAWWFNDHFTGITNQLTSLANLGYLAGFVGMLTDSRSFLSYPRHEYFRRILCRLLGEWVEDGRFPQDYDILGEIVRGISCDNARKYFAFPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I403</accession>
    <name>R7I403_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46360">
        <property type="protein sequence ID" value="CDE46360"/>
        <property type="gene ID" value="BN770_00841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="82" mass="9283" checksum="8F64867D41B46D20" modified="2013-07-24" version="1">MKSTGVVRQLDTLGRIVLPIELRRTMDIGVKDMLEIFVEGDEIILKKYHPSCIFCSDARDVVPYKGKLVCKSCLAELRNAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I447</accession>
    <name>R7I447_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46664">
        <property type="protein sequence ID" value="CDE46664"/>
        <property type="gene ID" value="BN770_00978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="150" mass="17033" checksum="67E6B559553398D1" modified="2013-07-24" version="1">MIIEHQGQALTVAMEMERRAIRTYEHALLLAKDEEVRKGIEDILGDERRHLKRFTEMWDKTVNSAEQQVLLQAMAADVLFRGGVTEMAREDALTTLTGLYRYAMESEANAVETYTKFAEKCEGEARAAFLEIVREEAGHLAELKEKLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I472</accession>
    <name>R7I472_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="4" type="ORF">BN770_00992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46684">
        <property type="protein sequence ID" value="CDE46684"/>
        <property type="gene ID" value="BN770_00992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="183" mass="21156" checksum="527D3A1A4B0A4F8E" modified="2013-07-24" version="1">MKLTIYAKNMTVSPHVTRRIEKKTERMGRYLLPDTEMQVRLSKEPKRDIRTVEITVPMGNGVILRSEASEPENLFLAIDQALAKMERQIHRHRSKLDKRIRDDAFASNELEFIEDEDAAAEESVPEIVRRKTFPVRPMSVEDAAVQMEMLGHSFFAFVNAETEEINVLYQRKDGKLGLLEPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4F6</accession>
    <name>R7I4F6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">BN770_00838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46356">
        <property type="protein sequence ID" value="CDE46356"/>
        <property type="gene ID" value="BN770_00838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE46356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="226" mass="24216" checksum="A96D81B80D300589" modified="2013-07-24" version="1">MVLNIAMDGPVGAGKSSIADAVAKRLGILHLDTGAMYRAIGLTALEKGVPVQDEQAVTALCQALSMTVGHAADGQHTLVDGRDVTGFIRTPEVSMAASTVAKYAGVRAAMVALQRRLAQETPMLVDGRDIGTRVLMNAPVKIFLTASAEERARRRYQEMRNKGMDANFDDVLRDLRARDEQDTHRAVDPLRAAEDAVTVDSTSLTFDEVVEAILRIVADKTGGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4G1</accession>
    <name>R7I4G1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-ACP thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-ACP thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46361">
        <property type="protein sequence ID" value="CDE46361"/>
        <property type="gene ID" value="BN770_00842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:acyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045023">
        <property type="entry name" value="FATA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727">
        <property type="entry name" value="PTHR31727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27855" checksum="FFC005870AB6C870" modified="2013-07-24" version="1">MLKIYKEDFTVRSYQTDLNARMKPSAILEVMQEAAGQHSERLGLGRSALLAKNTAWVLTRVEVDMDRYPAFEETFSVETFPMPVRRCFFPRYFIFRDSNGIEIGRAATLWVLLDLGTRSMTKLDVVKALMPDNSDLLAPLGLPAAVTEVSGTLQTEMRQPRYTDLDFNGHVNNTRYLDWCCDALGIDTMRGAYLKHFAVNFDAEVMPMQQIRTELRRLGDDFSYCGFEGDKRHFDVGGLLARQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4G5</accession>
    <name>R7I4G5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BN770_00847</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46366">
        <property type="protein sequence ID" value="CDE46366"/>
        <property type="gene ID" value="BN770_00847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="DNA_Glycosylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005760">
        <property type="entry name" value="A/G_AdeGlyc_MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01084">
        <property type="entry name" value="mutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="14">
        <location>
            <begin position="37"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE46366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="356" mass="39829" checksum="1516E193147829B1" modified="2013-07-24" version="1">MRETISALLLAWYDQNARTLPWRGIHDPYRTWVSETMLQQTRVETVRGYYERFLARFPDVAALAAADEADVLKLWEGLGYYSRARNLHQAARQVVRDFGGEMPREVAQLRQLKGIGAYTAGAIASIAFDQRVPAVDGNVIRVASRVMGIRENVGIPSVRRELEEKVDSLVPAARPGDFNQALMDLGAAVCVPGTPNCDICPLRAHCDAYDAGDAEDLPVLPQKNPPKPFDWDVLLIFSGEKVLMRQRTETMLHGLWVFPMLPGHSEHPAELGAQLHLAVRNVRPAGEAKHVFTHQIWRMELYQMEAVTADAPKGYRFVALDEMDALTIPTAMKAAGKVARERLEENSECGMRNKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4L6</accession>
    <name>R7I4L6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46198">
        <property type="protein sequence ID" value="CDE46198"/>
        <property type="gene ID" value="BN770_00776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010466">
        <property type="entry name" value="DUF1058"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06347">
        <property type="entry name" value="SH3_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435383" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="470"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="547"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="695"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="883"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1032" mass="110277" checksum="B8522586BE6A14F6" modified="2013-07-24" version="1">MQFRYQRALCLLLMLFLMLSAMPTSFAEDTADIAVYSAPLERSAATRNGMVRVRLLSIGSNPASLTVTAVGAMAVSGGQTMALANGEQISISHSSATGEIRLTRGGETLSMGREMALRRRQTDGGFRIAQARRPQNVYPGDLHLVSKLESGAYRLYVVANVYIESYLYGVVPYEMGSSSALEALKAQAVAARTYTLRAMNANASKIYDVVDTTADQVYNGSPAERDRAAEAVDATRGIVAMNDGKLTGTYYTASNGGQTESARNAWGSSGVNYLTVKDDPFDRMNPYSSTRKMTIYAAFSHASQNQTLTRLLQAKAPNATILRIEAVTPHTPKYAAPSRLYTKLDFEVTALVDGETRRLTLTFDIFSELESALNLSINKTKNELWSVKADGETFVLTVRRYGHGIGMSQRGAQQMANLGYTYDQILGFYYENCVRMQYTFTHTILPPVGDAPVTATEAPATISPAAPNQAMVTLVNVEDVLNVRLTASDNGTLLTTLPAGTAVTVLAKGDNWTLIRFGRIVGYVRTENLTFTGTQPTQSDENPTPITRWATVTGTNSLNLRASGSYDAAVQSTIPGGAVLCVFAVENGWASIQYGAKTGYCAAEYLTFSDTYPGKTSQTGRSAMVRTATALRATPSTAAVVLMNLPQGVQIAVQSSDGSWCRVTAGGIDGYVLASSLDFSAVGIELTPVPTTSGEQTAIVNSTASTLNLRQGAGTEYPVLAEIPKGTSIIVTAYGETWCAVRWGSLTGYVMTQYLRFDVPSGTPTPGGTPAPSGTPTPGATLEPTASPEPSEAPTPVPAASEPPAKVEDDVSAGSYVAWVSADNAPLRQTMAADAAVLATIPRGTQVTVLAQDGNWCYASVGQMTGYFTADALSCEQPDAPLGQKYVSTKSDSLAMRQSPNAGASIVQWLPRGALVTFISQENGWSYIRYGGKEGYCASQYLSDSAPGAVVISDTPILDVTLEKVTGWTARIHQAETLYQWCSADAPETAKVEADLVLTVLEKGEIWCRVRTEEGEEGYCLTSRLTLIAPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I544</accession>
    <name>R7I544_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47004">
        <property type="protein sequence ID" value="CDE47004"/>
        <property type="gene ID" value="BN770_01100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="200" mass="20964" checksum="6A7ECDACF2C6FB1D" modified="2013-07-24" version="1">MLNSATQTLTFSMASADGNQNAITGSISSVPAAFVTDAKTLQAKFALTSQHSETQDSDGTRHDDSAWTLTIEPDTDGAEAADLVTFEPITAELSLQYSTESREGAPIQLRVIAALHMAEADVGVKMALRTTSRWNALTLPTQGAEDVMSMDTMRAVQLLTTASDNLTRLIAGGSAPAATTAPELPTPEPNTTPVPSLTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5F1</accession>
    <name>R7I5F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 3 N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46860">
        <property type="protein sequence ID" value="CDE46860"/>
        <property type="gene ID" value="BN770_01059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448001" evidence="3">
        <location>
            <begin position="32"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="471"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="799" mass="85812" checksum="F54332C3432B5CB2" modified="2013-07-24" version="1">MKAKKFTPAMRGLAALMTCLMVLSIVGTGVANTYRGALDDTLGTESYVTINDDSAARFKTDYATIEDMAAAARDIAIREGEEGTVVMKNDNGVLPLKANANVALFGLAAYNVYGPKGGNADAASLADALAGAGLNVNETLKDYYLTNIINMHTEMRANRWTGKEVPTTVYDHMYVSAPGDWTTYQIAEVPPTEFEALGVPANWKEAIAKDSIGICVFARGAGEGNTYKPGSALNYAGEATGEDPLKLSADELAVVEAAKATCSKVIVLLNTGNNMMIADIAEGGSHEVDGICYIGCPNDYQTIGIANVLTGKVNATGALASAFVRDHQSIPAVQNVGGDYFADYEIVCRNDDPRYPGKEIGNIGTGSFGGADTYNGGMYIVEAEGIYVGYKYYETRYFDAVMGQGNANSAAGATQGSAWNYSDEMLYTFGHGLSYLDYTQTIKSVTVDRSVNGNITAVVEVKNNSNQDGKFLTQLYVQQPYTDYDRTNLVEKSAVMFLNSAKVDVAAGKSKEVTITIPTKYLASYDANNAKTYILDAGDYYFTAAAGAHEAVNNILAAQGKTVADGMDAAGSKAVVSWKLDQLDNTTFAIANNTTVTNVADDADLNYWLPGTVTYLTRQDWNTFPINYNKLNLKIADSPKKDQWIAEMRGETYTISDTGAAAEAVPGPKFAASEIGAEQLNNINDPYWDKLVHAITIDEAVGAVIHGGSRSDTLTNIDNPVVIQNEGPTGISAGYTDEATGKTYKFNVNSQTLLGCSFNPELAYQWGLVEGNSCLWVERYDLWGSGLTLNRTPYNGRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Q7</accession>
    <name>R7I5Q7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="4" type="ORF">BN770_01031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46811">
        <property type="protein sequence ID" value="CDE46811"/>
        <property type="gene ID" value="BN770_01031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="82" mass="9477" checksum="89458EFAAC7BD15C" modified="2013-07-24" version="1">MSVKIRLKRMGMKKKPFYRVVVADIHSPRDGRFIEEIGYYNPMVHPAEVKVDGERAKYWLTCGAQPTDTVRVLLKKTGVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5U5</accession>
    <name>R7I5U5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dxs</name>
        <name evidence="12" type="ORF">BN770_01114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47020">
        <property type="protein sequence ID" value="CDE47020"/>
        <property type="gene ID" value="BN770_01114"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE47020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="628" mass="69297" checksum="62E4280F515C0B5A" modified="2013-07-24" version="1">MRLEDIKSPQDIKGLSYAEMNDLAAQIRTELVTTISKRGGHLASNLGVVELTMAIHRVFNMPEDKIVFDVGHQSYVHKLLTGRYRTFCTLRSFGGMSGFPKRSESEYDVFETGHASTALSAALGLARARDLQGQHHHVLALVGDGAMTGGMCYEALNDAGDSHTRMIVILNDNEMSIAPNVGALSQHLTDLRVSSGWTSTKRVIRKGLSCLPVVGKPLQCFLSWAKKSVKSMFVRENQEGFFNSLGFHYFGPINGHDLKALEHTLEAVIQLDEPVVVHVLTKKGYGYSAAEDKPERFHGTLPFYVETGTARKKGTLPSYGQVMAETLSEMAKTDEKIVAITAAMPSGTGLSYFAERFPRRMMDVGIAEEHAVTMAAGLAAGGMKPYFAVYASFFQRSFDQMIHDVCMPKLNVTLLLDRAGLVGEDGATHHGVWDLASMLPVPNMVILAPRDLNELRTMMRWTQENESPCAIRYGRESVDLSARYPAQDKPFRIGEWELMEQGEDVALLAVGSMVAEAIEVRDLLEKRGIHAALVNCRSVKPMDEKMLHQLANRPIVTMEEHVLTGGFGSVVCAFLSGEGLPAPMLSFGIPDTFVQHGRRDQLLKYLGLTPELMTQRIVIALKNGEKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5W9</accession>
    <name>R7I5W9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46648">
        <property type="protein sequence ID" value="CDE46648"/>
        <property type="gene ID" value="BN770_00970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="204" mass="23123" checksum="4ADDD9D0C814F549" modified="2013-07-24" version="1">MSNPHRISIFLILLLFLGLIFVAVSDLLSFHEDDFDLSEALVQVQVQTPRHYGSSDVEEPVNYLLASKRRIHSCDPFTADEATVYYVPSECFDAYIDRAQNKVLNRLVSVAVTDESGNPCEAPAVLSDIFAQIATLEHTLFDIRILDVSGEYFVFLKLNVNLHTPCELYYYNQQIGKLIELYSFNDRELLGLHVMSVEGLKGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7I699</accession>
    <name>R7I699_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutL</name>
        <name evidence="8" type="ORF">BN770_01229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47384">
        <property type="protein sequence ID" value="CDE47384"/>
        <property type="gene ID" value="BN770_01229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="7">
        <location>
            <begin position="210"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="6">
        <location>
            <begin position="481"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="666" mass="72621" checksum="86A3CB6A4E28AAE6" modified="2013-07-24" version="1">MAGKIQLLSDEVIGKIAAGEVVERPAAAIKELAENSLDAGASAVTVEIRDGGISYFRVTDNGSGIRSEDIRMAFERHATSKIRRTDDLFSIQTLGFRGEALASIAAVAHVTCTTRTKADQSGIKVQNNGGTIESIEEAACPEGTTFVVRDLFFNTPVRLKFLKKPVTEAGYVSDLMMRLILSRPDVSFRYISQGKTLYHSAGDGKLSSAVFSIYGREMLHSMHEVDGHQAGLILKGFVGVGESGRGSRNHQSFFINGRYMKSSILSAAVEAACRERVLSGKYPTCVLHLTMPYDTVDVNVHPNKLEVRFQNEAAVAEAVEAIVADALADKAPVEQPDVLRLTPEPPPTVPVTVVRQPVTASEAVQPEAAVRSAVPPKAEKKPTVGTEIPQKAAIPAKNPPIPTPCAPPDKPSAPPKTAPNDAIPAWKQPLVMRSPSALAQHYNAEPAVPPPGNPLKPTASLVSPIPVQQTILPNEQTNMRIIGTLFDSYILVEYADNLMLIDQQAVHERVMFDRMMKALDQHRCGQEMLVPMIVSLTRREQQLLDEYARELADIGLVVEPFGENEVSIRSIPMILGQPQAAGLLRDIIDQLENERGVVSLEKRRAAILALACKRSVRSGERLNDADIRELVSRVADKRVIPASPRGTPLVVALNKTDIDRRFRRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6F2</accession>
    <name>R7I6F2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000039">
        <property type="protein sequence ID" value="CDE47220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47220">
        <property type="protein sequence ID" value="CDE47220"/>
        <property type="gene ID" value="BN770_01171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="367" mass="40495" checksum="74CC3B66950C0C0B" modified="2013-07-24" version="1">MYGKAKVGRPDWYMMGACIVFALTFSLRSVPLAVLLLLFMPFSLLSLTGELPLPTRNAPICQTLLCISIPLLVIGAFSSLLLLLPKLLIPSACVWLFGGALMLFLPPGAFRKSRMAMYWAVICFAAVVALLMMLLQRYQAYGDLYEGLSYDILRVMMNARTRPQVLYSAYVSGLAALDAKRTAALESLAALTGGNVLPWLSEDVLQQLEWSLRATIEITLPSIMPDLLVKGIMAFSLGMLLCWRKFPDAADTPTTDRWFMPTPLGISMAVLLLLSAAQLFTTNATVALAASLLGSVAFWSFAVQGVSAQNFAMLRAGATRGRRWFLTILMVLFVPILPMFAGCVDQIRDPRGLRDDRHRKDDDFSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6G6</accession>
    <name>R7I6G6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47081">
        <property type="protein sequence ID" value="CDE47081"/>
        <property type="gene ID" value="BN770_01137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="192" mass="20727" checksum="4B68BDE238D8CC43" modified="2013-07-24" version="1">MNHAALILASGSPRRRELLSLTGLPYVVDAPEVDESCALPPEEAVQEISRRKGLAGAAAHPGCVVLSADTLVAVDGKALGKPHSEKEAFQMLSLLSGRWHQVYTGVCAVDAQGMVHQRVVGTQVHFCPMTEEEIRRYIATGEPMDKAGAYAVQGIAGLWIDKLEGSYSNVIGLPMHTVRELLDECGLHCWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6K9</accession>
    <name>R7I6K9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000034">
        <property type="protein sequence ID" value="CDE47126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47126">
        <property type="protein sequence ID" value="CDE47126"/>
        <property type="gene ID" value="BN770_01152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="117" mass="13096" checksum="17837FFD1F364A54" modified="2013-07-24" version="1">MYGQNIRLFRKQKGMNQHELGAAMDVSAVSVSKWEREQTQPDIETLQKLADLFDTSIDELCGRPPKPEDAMDNMSVMCRAFRQMKPEEQEKYLAVGKALFASAFAPAAPAQDDDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6X7</accession>
    <name>R7I6X7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">BN770_00806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46257">
        <property type="protein sequence ID" value="CDE46257"/>
        <property type="gene ID" value="BN770_00806"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="423" mass="45428" checksum="AB30743AD664B625" modified="2013-07-24" version="1">MKKTFFPAHLIGTVSAPASKSEAHRRMICAGLTQGETILTGFMDSADMAATMRCLGALGSTFNRDGDTLTISGMQGKIAKMPVMDCGESGSTLRFFVPIALTVAGGTVFRMHGRLGSRPMDVYRDLFVPRGVRWYMGVGADGAAELTVRGKMEPGDYVLPGDVSSQFVSGLLFALPLLPGNSTLTVQQPVESESYIRMTIEAIAASGIEVQESNAFSWRIPGHQQYKSHSCHLNGDYSQAAVLCCAGALGHDITVTHLSPVTTQGDRAILRHLMALGATVEESDNHIRVKAGKLHGATLDMHDCPDIAPILALTAQLAEGESRLTHCGRLRLKECDRLAATVEILNLLGGDAKADGDDIVLHGVKQLRGGVTLPNYGDHRMVMLASIAATKCEQPIEMDGIEAIDKSWPEYLKVYQMLGGKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I773</accession>
    <name>R7I773_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000034">
        <property type="protein sequence ID" value="CDE47128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47128">
        <property type="protein sequence ID" value="CDE47128"/>
        <property type="gene ID" value="BN770_01153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="108" mass="12282" checksum="D467220B2F6A48C2" modified="2013-07-24" version="1">MTRQQMLESYRKLVIAKQDAAHMMSADDHDAMFSQTLQAKAKSTLTAMNAPMRALLEEINDPRTFMIIQRYYVKGLTDQAIGREMNLTGARVNQIRLGYVRSLTNQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7D2</accession>
    <name>R7I7D2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47396">
        <property type="protein sequence ID" value="CDE47396"/>
        <property type="gene ID" value="BN770_01241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09024">
        <property type="entry name" value="Aldose_epim_lacX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037481">
        <property type="entry name" value="LacX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="293" mass="32864" checksum="7C8F89AD7804908C" modified="2013-07-24" version="1">MEFTLHCGDTTARVRQKGAQMTSFKGNDNREVIWQADPAVWGNHAPVLFPICGTAKDNHVIIDGVSYPIAKHGFSRNPEFTVEKIGDDFIELVLTPTEESKPSYPFEFAFHVVYTLRENGFSAQFIVENKSDKVMPFCCGGHPGFIVPMEAGASYTDYELVFPQVEDGRNSLCPGGYLIDGSEYLPCFHNSRVLPLSHDLFDDRDALIFTELKSRSVDLVNRSSGKGLRFSYPKMEVLAVWSMPKKNADYVCLEPWHGMPGQVTESGHFEDKPFVTLLQPGHSWQGGYDVQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7H4</accession>
    <name>R7I7H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46472">
        <property type="protein sequence ID" value="CDE46472"/>
        <property type="gene ID" value="BN770_00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="360" mass="42217" checksum="11EEBA099D57FEAD" modified="2013-07-24" version="1">MQKLRGYLALGTFIMGIASFLCLLLPLIEITDDALMLMVFAVPPLICGLFIALALHMLLYTLLLVLYGCRIQLVDLYFLHIRRKTVGWRVQYLPAAERNVGILLAAVPWEQETGDLQQRAQIVLYYVQSVLAILFYALAVNLYGTASAIACLVLAWGYAFLSIIMPPSEIRKVFQPEKRRKMWQMQCLLAENLTDRLLTEMPEEYFTPPDKIQDQNDAALMINRSARLMMQNRYGEALDILTMLAQEHREQTKRLWWQLIPRGVLCELALDKPGYFLKEYDTLYMQKELRKHEKQPLVWRTAYAVHLLRDGDEQKAEQCRKQFLRRIRHTTMPRCYQWTIDRMTQEKEIYESRKAKEAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7K5</accession>
    <name>R7I7K5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000066">
        <property type="protein sequence ID" value="CDE47834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47834">
        <property type="protein sequence ID" value="CDE47834"/>
        <property type="gene ID" value="BN770_01383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="179" mass="20463" checksum="2CA467CDC37897F5" modified="2013-07-24" version="1">MRKQVLVPENVEMADIHAIQTRVKKHNLLTVVLLIPLFAGCALRESHETLGGIVFVLSMVLMVLGFVSGRGDEKRLPAYWAKYQQIHRMDNLLRANLVGVWLCAEARVAVYREGSGYRVQLGVLDEKTGAWENDEQDEVFPTLADVREYATQEGYEPMAVDFETMTDEEFQQFLDRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7M6</accession>
    <name>R7I7M6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47859">
        <property type="protein sequence ID" value="CDE47859"/>
        <property type="gene ID" value="BN770_01394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="230" mass="26326" checksum="AEFCEEBDC0A07CBC" modified="2013-07-24" version="1">MGEKIRRKALLILSCVLMLEAVGIRHVPNFQRVGLILYAAGMLAMYAMTLRRKIKGLAVNENDFMPFLFGAGLLAIEVRRYDFGEEGKLWLWIIIISLLLALPMLLAERRVPSGKAGNNKYWMRAITIVFLIVLSCFNWVYATNVAFDTSEGTATTGIITRKRMEKGTKHRMSYYLEVSKPLTNETNTFSVSKSDYNRYDEQRVVTVTEHPGFWGAPYYEVELPKPQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7N2</accession>
    <name>R7I7N2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted unusual protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46532">
        <property type="protein sequence ID" value="CDE46532"/>
        <property type="gene ID" value="BN770_00926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1" evidence="3">
        <location>
            <begin position="107"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="560" mass="61864" checksum="FCA506399A96897D" modified="2013-07-24" version="1">MTEKEQQPVAPEIPTEAADKPESDNPPKNENRRGANQAERERTIAQNRQRLREIVDVVRKHDILHGITPEKLCAIIEDLGPTFIKLGQILSMRSDILPRDYCEALKKLRSNVSPMPFEQVQRVVETSYGCPMEEVFASFDEKALGSASIAQAHAAILKSGERVVVKVQREGIHEVMSRDIILLKQACKVLKYTPAGSLVDFNQVLDEMWVVAQEEMNFQTEAANLERFHALNQDVVFVTSPILYRAYTTTNVLVMERIDGMGIDEHDKLVEAGYDLAEIGAKLADNYVRQIMEDGFFHADPHPGNIRIRDGKIVWLDMGMMGSLNEKERKLIGNAIVGVARGDIALVRDAVLGLGEFHGTADKKQLYRDIEAMLDKYGSADLGTMDLAEVFEDMTSVMKTNGIAMPSSLTMLARGLATIEGVVADLSPELNIMNVITARIGDQMFDNVDWRALLTQDARAIYESSRKSLEIPALLADILRTGLKGEANLGVEHHAGEDVRKLVIAMVRKLCLMLLSLGLLIFGGAVAGNGPQVFGLSIYSSGCFVLALCAAGFALWNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7R3</accession>
    <name>R7I7R3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000042">
        <property type="protein sequence ID" value="CDE47303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47303">
        <property type="protein sequence ID" value="CDE47303"/>
        <property type="gene ID" value="BN770_01204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435573" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="46" mass="4839" checksum="5427A3B54EE115FA" modified="2013-07-24" version="1">MRKLISLLVMILLLLSAALAEVSTPTCATVTLTTGSVHGGFHREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8D5</accession>
    <name>R7I8D5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">era</name>
        <name evidence="13" type="ORF">BN770_01405</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9 10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47870">
        <property type="protein sequence ID" value="CDE47870"/>
        <property type="gene ID" value="BN770_01405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="12">
        <location>
            <begin position="8"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="204"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="9">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="9">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="9">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="9">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE47870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="298" mass="33017" checksum="41B92D2A8238D720" modified="2013-07-24" version="1">MSENTKFHSGFITIVGRPNVGKSTLMNAMVGEKIAIVSSRPQTTRNRIMGVMTRPDWQIVFLDTPGIHTPRTKLGESMMQSVKDAMDGMDGVLVLVDATQVGEHDRAIVRDMAGKKVPKVLAINKIDLLPPEKLLGLIASFADLGYDAIIPISAKTGDGLDALTKQLATHLPEGPKYFPDDMMTDQPERLICAELIREKALQHLRDEVPHGIGVEMMGMEKMNDNFMEINATIYCERDAHKGIIIGKHGAMLQTIGSEARGDIEKLLGLHVNLKLWVKVRPDWRNRASDLRTLGYDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8G0</accession>
    <name>R7I8G0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47578">
        <property type="protein sequence ID" value="CDE47578"/>
        <property type="gene ID" value="BN770_01292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="450" mass="48715" checksum="9B4D7250FB0C1F40" modified="2013-07-24" version="1">MSKKNPIQLSDHFTYARLFRFVLPSIVMMVFTSIYGVVDGLFVSNFAGKTAFASINLIMPFLIILGAMGFMLGTGGTALVSRVLGEGDKEHANKYFSMITLFGILLGVILTVVGVLAMRPMAILLGATEAMVDDCVLYGRIVVCFLTSFMLQNMFQSFLIAAERPKFGLLITLAAGVTNMVLDALFVGVFRWGIAGAAIATGISQTVGGVVPLMYFLFSKSSPLRLRWTEFEAQPLLRSCANGSSELMSNISGSLIGMLYNAQLMRFLGEDGVATYGVLMYVQFIFVAIDIGYSIGCAPIISYHYGARNHPELRNLLTKGLKVMGILGIVMTIAAISLSGTLANIFVGYDATLCELTRHAFHLFSFAFLLAGFNIFLSSFFTALNNGGVSAAISFLRTLVFQAASVILLPMALDVDGLWWAASAAEALAFVVSIGFLLAMKGKYHYFDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8L0</accession>
    <name>R7I8L0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000088">
        <property type="protein sequence ID" value="CDE48209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48209">
        <property type="protein sequence ID" value="CDE48209"/>
        <property type="gene ID" value="BN770_01577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="412" mass="45404" checksum="952C460B9981EA5B" modified="2013-07-24" version="1">MPQLVRDGERIRQVVIVIQQHIGVHVAQVAGGERAGGLALGGVHVNPAADAGFAQLGQIVLAHGLQAFQHKVKRLVVAQLHVEILDHRRVEVVHVQFIQPHQLFAQRQILIQHRNRGVHFADEVVVDARGDFQRLHAGIAGGGVMAGARLEHVVLHAAVVRRGDGVAEIAVGVHDAVERRFADFAVFRADKLGICAFSQLSSRAVGHLHGREGHIHVGQHPEDVVRGLGDLPHHGEQLLLLGRQRVRLLANQVAQERVIIRHCRISGNFRQQRIIQREQLRLKEGHRGGQLYAHLGRAGAKSLRNRVAVVRFAAQERVGENGISLLIQIEILANGLTGIFGDFALPRGELLAGRKHIRQSGLPRGIIRVNVRQVPFVLRGDFLTLAELCSHCKTSFCRKKTGVSISFPRVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8M1</accession>
    <name>R7I8M1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="8">IMP dehydrogenase</shortName>
            <shortName evidence="8">IMPD</shortName>
            <shortName evidence="8">IMPDH</shortName>
            <ecNumber evidence="8 15">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">guaB</name>
        <name evidence="17" type="ORF">BN770_01056</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 15">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 14">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="8 15"/>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46857">
        <property type="protein sequence ID" value="CDE46857"/>
        <property type="gene ID" value="BN770_01056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 8 15" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="6 8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 8 15" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="94"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="153"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="384"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDE46857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="485" mass="52056" checksum="C2BD9A252EAA8C01" modified="2013-07-24" version="1">MLQKVVREGLTFDDVLLVPARSEVLPKEVDLSIQLTPVIKLNIPLMSAAMDTVTDSRMAIAMAREGGLGIIHKNMSIAEQAAQVDKVKRSEHGVITDPFFLSPDHLIQDAENLMARYRISGVPITRDGKLVGILTNRDLRFETDYSRKISEVMTSENLITAPVGTSLEQAKQILAKHRIEKLPIVDENGMLRGLITIKDIEKSTKYPNSAKDAKGRLLCGAAVGVTHDVFDRIEALLDAKVDVISIDTAHGHSVGVLRQVEAIRKRFPDIQLFAGNVATAAATHDLISAGVDCVKVGIGPGSICTTRVVAGIGVPQVTAVADCAEEADKHGIRVIADGGIKYSGDIVKALAAGGSCVMLGSMLAGTDEAPGATEIYQGRSYKVYRGMGSLGAMEHGSKDRYFQEDAKKLVPEGVEGRVPYKGILADTIFQMVGGIRSGMGYCGAKNIDDLRKNSEFIKITGAGLAESHPHDISITKEAPNYSRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8P6</accession>
    <name>R7I8P6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YqfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47866">
        <property type="protein sequence ID" value="CDE47866"/>
        <property type="gene ID" value="BN770_01401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010690">
        <property type="entry name" value="YqfD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06898">
        <property type="entry name" value="YqfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="385" mass="42332" checksum="381DB9589A3EF133" modified="2013-07-24" version="1">MSGRPWLIAVTVDGVNLPRFLRRAGEMGLLLTGVRIRGKHLSAFAREDDVPPLRMMAENGGWRFSVGNRQGTGRLMTWIRHRLALLSALMLGIGALIGASQVMWRVEIENAGIYAADLPEYLQALGITPPMRKSDVHPGQLRDLLEWRYPETAWVECGWRGMTLLIRVVDGVPAGTPLSETGAGDVVAARDGIVDSIRTKAGTALVQPGDVVRKGQILIRGEERTGSGVRAVSARGVVMARVWDAAAVRMDLTELHTSYSGRTEESVSVVSPWFALWHEPESAFHQADVSRRTLPLGGFFLPLTCVWEKRYECEITKQNRANEEITAEASIAALRKLREIIGTNESLVDKWVNCSMIDHEVLLAVATGERLVDIAEQIPSGAPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Q8</accession>
    <name>R7I8Q8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">BN770_01482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48000">
        <property type="protein sequence ID" value="CDE48000"/>
        <property type="gene ID" value="BN770_01482"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="255" mass="27968" checksum="ED08306883A9D9CE" modified="2013-07-24" version="1">MILTLDIGNTNIKTALFDGKEMRYYWRMSTNIQKSSDEYGIVLVNLFQHVGVRPEEVEGIMISSVVPTINFTIEHMCQNYFGQTPLFVVPGIKTGINIRYENPRELGSDRIANAVAAYEEYGAPTIFIDFGTATTFGVVGEGGVFLGGCICPGVKLASEALVTGTAKLPRFELTKPEHVIGRTTLTNLQSGMYYGYVGLVKNIVRKIKQELGQEATVVATGGMAVMIAEESKVIDKLDGLLTLKGLRLIYERNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7I924</accession>
    <name>R7I924_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">BN770_01116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47022">
        <property type="protein sequence ID" value="CDE47022"/>
        <property type="gene ID" value="BN770_01116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="279" mass="29454" checksum="3046292CAF54D068" modified="2013-07-24" version="1">MRLGIVIHGHRPDAMAAAHHAVAQLASCGAQVLVEDEVLAAFASGSVTSLNAPDARADVILSLGGDGTLLRGAQYALSWDAALLGVNLGRVGFLAEGEADALPRLLDKVIRGDYETERRAVLSVQMNGQSWYAINDVVMSRGGYARLITVTALVDGALAGHYIADGLVVATPTGSTGYSLSAGGPIISPKVDCMVLTPICAHSLQHRPTVVQGSAQIRLLLGSDAPQSACLQVDGQTYAQLDDGAVVEISRADRTLQLIRTSDQPFFNLVREKLTEWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I995</accession>
    <name>R7I995_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000066">
        <property type="protein sequence ID" value="CDE47838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47838">
        <property type="protein sequence ID" value="CDE47838"/>
        <property type="gene ID" value="BN770_01386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="263" mass="28952" checksum="90DE59ECD06570C3" modified="2013-07-24" version="1">MALASIISQYISAALVILSLRRSGSVVRLERSMLRIEPHKAKQVLSLSIPAGLQNAIFAIANLFIQAGVNSFDELMVEGNAAAANADALVYDVMAAIYTACSSFMSQNYGAGKRKRIIHSYFISMVFSFGIALVMSALLVIFGRQFLGIFTNVEEVAQAGMIRLRIMGCSYAFSAFMDCTIAANRGLGKSFVPTVIVIMGSCVFRIIWVYTVFAYFHTIESLYLLYIVSWAITAAAEMICLRRVYREQMQKLPPDIDGVKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9D9</accession>
    <name>R7I9D9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligoendopeptidase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000089">
        <property type="protein sequence ID" value="CDE48210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48210">
        <property type="protein sequence ID" value="CDE48210"/>
        <property type="gene ID" value="BN770_01578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="139" mass="15503" checksum="F6A8C955B6DFDE2D" modified="2013-07-24" version="1">MFAEFELIAHTMAEQGQPLTRESLSKAYYELNQKYYGAVCTVDENIANEWLRIPHFYRSYYVYVYATGLCAAVSLSDKILSEGASAVRDYRKFLSAGCAVPPIDALKLAGIDMSSPEPIRRALGVFKDTLAQFKAVIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9G8</accession>
    <name>R7I9G8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000111">
        <property type="protein sequence ID" value="CDE48529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48529">
        <property type="protein sequence ID" value="CDE48529"/>
        <property type="gene ID" value="BN770_01723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="404"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="570"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="804" mass="90412" checksum="1F4254389243DA2D" modified="2013-07-24" version="1">MISVVLPAYNRRNTVRKAVESVLNQTERDIECIVVDDASTDDTAGVMTEISDSRLRIIRLTENSGACHARNVGVQAAKGEYIAFQDSDDCFHPDKLERQLAFLQETGADVVFCGMNRICGQQMEVFPAYVPDKCINRIDLLEANLGSTQCIFGKTEAFRNTPFDEDMPRLQDWALMLELVKKYIVRGEATPLVDVYVQPDSLSNQPKKLFPALRRIYLRYAETINAICPEHWTIILTQAAERIGEEAWQGELLENAPECVVRPEQIASMGNIVLGQGDENPQGKILLTRNLSDMQEVRDRYYYLPRNLLGKALKESLSVEIAGRTAVYPLQRLSAMLCGWLNHQEAWETVTQIYAEEEIIETLAADQLMEMPLWARVIRQAGRKKLPDKPIRRVAAYYHNVHGGGVQQVTAKLLHAWRKMGLEVTLITSQQPNEEDFPLPKGVRRVVIPPFDPFDWESRSAHVRRLAEVAREVDLVVDHAWADPMVLFDVLAIQSAGAKVLLHTHSVFSMTLLKRELHDRFQCLPDVAAMADGVVALTPADACYWRQFSPRVFETRNPIDVADVPLNALGGRTMLWVGRNSPEKRPMDAIKAVMWIGDRVPGAKLIIMGGGFEHEAEMNWLKNVEYVGYHQDTEEIFRQADIFLCTSEYEGFSLTMAEAQAHGIPCVTYDMPYLPILQGGGHVAVPMGDADALAKAAADLLLDASRRVALGQEARKNVERLCIDQTAKWTEIFAQMAEAKGKAHPDAAVQQMVSTLSEHALRQEKEIVFHEIEKPEFIPMPKHGPFKLLRKKLATACKLLLVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9H5</accession>
    <name>R7I9H5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000037">
        <property type="protein sequence ID" value="CDE47167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47167">
        <property type="protein sequence ID" value="CDE47167"/>
        <property type="gene ID" value="BN770_01163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="260" mass="27166" checksum="1A88A86FF807F9E3" modified="2013-07-24" version="1">MNTQVLQGLLVPFLGTTLGAALVFFLKRDLPEKVQKGLSGFAAGVMVAASIWSLLIPALEGAADLGAWSFLPATIGFWLGILFLLLLDRLVPHVHLDGEQEGLRASLPRSMMVALAVALHNLPEGMAVGVVYAGSMQPEQVGSVSFASAFALAVGIALQNVPEGAIVAMPLRQAGMSRVKAFTLGMLSGAVEPLGALLTIGLAAVFAPMMPVMLSFAAGAMLYVVIEELVPEMAQGTHTNVGTVLFAVGFSLMMAMDYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9M5</accession>
    <name>R7I9M5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47998">
        <property type="protein sequence ID" value="CDE47998"/>
        <property type="gene ID" value="BN770_01480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="304" mass="33068" checksum="BA419B785E5E4EAA" modified="2013-07-24" version="1">MKLLILGGSGFVSGRLAQIATAQGHEVWCVTRGNRPIPEGVHALTCDAHDPAALRAALASAQLQWDAALDCICRDAPSASVDLSVLPAFTNRLLVISTDSVYHPAYKRVPQDEIGVYLHDGGYGSSKRQMEEVFLDAAAHSESPFAWTIFRPGHIFGAGSQVGCFPEHSRQPDLIARMKRGEPLRLVGGGKFLIHPIYVDDLCRVLLESIPVSTSFNEIFCIGGPDIVSNAAYYLLLGEILNVPVSIEEIPLAGYLEAHPQFSGHLCHRAYSLEKLRRTGIALPGTPLRAGLQKQVEWLLSLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9U0</accession>
    <name>R7I9U0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47272">
        <property type="protein sequence ID" value="CDE47272"/>
        <property type="gene ID" value="BN770_01194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435613" evidence="3">
        <location>
            <begin position="24"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="313" mass="33467" checksum="F08A61EB60FEBE56" modified="2013-07-24" version="1">MKRRVSDIAVMILSFLVLLALSAETALVGVEAVRGEQWQLIRLTAWLQGSGVWGGIACIAVAVLALALALMCLWRVFPHRTASQRGYVMQKNENGSIGVSIRAIEGLIRTCIDKHEAIAKADITVEECRDGIAIGLHIIQAAGVNIPLSVGALQKQIKQYVTACTGVDVYKIRVMVENDASIPVASTYEVQDVTPLPSAEETAEKPMVTPPAQPVAIPATEPEQKPKVPDTFISPEDDEDDERPLHQRLFGTPEQPAFVPAPPEVTEAPEADEVEAAEDAPEETEASAEEAAAAEESAGETVDAADDGEKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA15</accession>
    <name>R7IA15_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000095">
        <property type="protein sequence ID" value="CDE48306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48306">
        <property type="protein sequence ID" value="CDE48306"/>
        <property type="gene ID" value="BN770_01633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="6">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="210" mass="24001" checksum="03FB34CF9FAE8063" modified="2013-07-24" version="1">MKYKVMIVEDQTMPRELFELRIQASERFEVALSIDNAALADVYCLRFPVDLILMDVVTRGGESGLDAAERIKRTFPQMKIIIVTSMPECSYLSRAREIGVESFWYKEEQRESLLDVMARTMAGESVYPDATPELQLGLASSYQFTSRELEVLREMTGGDTNQEIAERLHMSVATVKTHILNMLEKTGFRNRTELAVRAREIGLVILNRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA23</accession>
    <name>R7IA23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000081">
        <property type="protein sequence ID" value="CDE48148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48148">
        <property type="protein sequence ID" value="CDE48148"/>
        <property type="gene ID" value="BN770_01560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="45" mass="4657" checksum="2F58CA95004EF414" modified="2013-07-24" version="1">MVQVNADAALLDGMENGMTVTVYSNGAMTMSLPGQIGAEKIVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA24</accession>
    <name>R7IA24_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48321">
        <property type="protein sequence ID" value="CDE48321"/>
        <property type="gene ID" value="BN770_01646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008875">
        <property type="entry name" value="TraX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05857">
        <property type="entry name" value="TraX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="272" mass="30035" checksum="D0AD1834220ACE74" modified="2013-07-24" version="1">MPSKDFAARRNPAIAGCTATGVLKILALVFMFIDHAGKMLFPQIAEMRMLGRIAFPLYCWCMVVGISYTRSVPKYLGRLMLIGLVSQPIYMVALNHSWNQPNIFLTLLVALCGVWGLKAKKLLSHIWTPILALFAAQLLGCDYGWRGVMLVMLLYGVRGSRAGIACVMIAFCLYWGGSSVGVTHLFGQDVTPLTSSAIGAVISPWLRLQTMAIWALPLMLLPISQQVKMPRWVGYALYPLHLVVLIALEAALAQPIHTENLINAWNAFVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA51</accession>
    <name>R7IA51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47397">
        <property type="protein sequence ID" value="CDE47397"/>
        <property type="gene ID" value="BN770_01242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="92" mass="10297" checksum="150DB07563434244" modified="2013-07-24" version="1">MRAAGSPFQAKSSQEQKEQWIWWQCQRDTVPPEEKAPPVNALPERDAPPMPIPVQPTRHQQYDAIMQRMKVAQGRTGAFTSCGTSTQDSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAB0</accession>
    <name>R7IAB0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_01833</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48814">
        <property type="protein sequence ID" value="CDE48814"/>
        <property type="gene ID" value="BN770_01833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="10">
        <location>
            <begin position="171"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="8">
        <location>
            <begin position="329"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="9">
        <location>
            <begin position="708"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="11">
        <location>
            <begin position="1019"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="12">
        <location>
            <begin position="1091"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1210"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE48814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1319" mass="140840" checksum="839E820CBFC258C1" modified="2013-07-24" version="1">MTDITTTLTYTADLTRPLRRMNIPALFITDARRAHRITVTVLRAGNPVDLGDTAVSGTVKHLRTGTTIPLSGSAQGSIASVTLPPAAYAQPGDIEIYVTLTSGDVQNCIFAATGCVFPSSTDRVADVPGFYSLAALQEQFSSLDARLRALEEIGIPVTTADQLVSAVPLNSWKFNLISATANTAYSSTAEAEAGFDDASWRTVSVPHDWSIALDFNSSSPATYEGGYLDGGDAWYRTTVSVDKQNGRRYVLCFDGVYMESTVYVNGQQVHKNYYGYNPFAVDATEQMVSGVNTIAVFVRNEQPSSRWYSGSGMIRPVELVTLLDDQIHMENIRVTTPKLDSDLTNGETVVAFDAVNRTGAEASATFTVDLYDPDGAKVGTADASAVIAAGETQNVSATVTYRSPKLWHISDAQQRDLIENGKSVSASGNPLTCENALAGKPLGALHVYGKSTQNGVPTPTAPVPIVSAGDGRTVVVTVSDGANNSQTLQTPNALPGIPVASSGNYTDESGQQWVCDEVDLARGVRVQRITKIKLTSSMKWTRAGNNVDRYFCTFDGIDAAGTFCTHFSAAINGETVGGIATSSSNIIGFAYAERGTTTVDDFKAFLDANEVYIYVPLASPIETALSSAEIAAYKALTTYAPTTVISASGVAGLAASYQQSILPSNAPTALLTASPANLYEAQISAKVGNRVQRSKRVTYGYRSIRFDKDTGFYLNGIHTKLKGVCVHHDGGCIGAAENRSAIERQVDILTNMGCNAIRLTHNPFGAEYLDVCQRKGVLLVEELFDCWTKSKKQKDFGRYFTDHYAEVVTSTIHRDWNNPAVIMWSLGNEVRTNLTLGDYSSSEIVNVCTTVNSAVKALDATRPTTMGNNAPGGNLSALMAIVDVVGINYNGNNQTYQTDRPIYGSETTSALSSRGVYATDSANMAYPSYDNKAVSWGNTAAETVNAYLNNARSCGHFVWTGFDYIGEPTEWNKYPAKSSYFGIVDTCGFPKDIYYMYQSMWDSRPMIHILPHWTHESGNIDVWLYSNCASVELFLNGTSLGKKALSQRGTKNQYAYTVAYAAGTIVANGYDSSGKLVAQDVQYTAGTPAKLALSSDKTAVNTASDDLVYITCDVLDKNGTRCPTADNSVTFTVTGGSIVGTDNGHGANVEKLSGSTHSAFSGKCLCVVKHDGASGAMKITATANGLTAGTISVTKGETTIAATAPAASFVDATNPPRRDTSEPTEPAPTISAISADKTTAALNEEITFTMTVKNTTSIRVYIDGSVNRYIYDVTDGTMTYKLSFTDAGSGTRTVAFEPCRGDVVGAKTAETVITLAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAF0</accession>
    <name>R7IAF0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48471">
        <property type="protein sequence ID" value="CDE48471"/>
        <property type="gene ID" value="BN770_01709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="48" mass="5451" checksum="94E79FBACF3AE37B" modified="2013-07-24" version="1">MTYYDTIFCIHLCRLFANLGEFLFGNSIKEAIAFVQSLFSARMANVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAI6</accession>
    <name>R7IAI6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48278">
        <property type="protein sequence ID" value="CDE48278"/>
        <property type="gene ID" value="BN770_01614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031612">
        <property type="entry name" value="Phage_holin_Dp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16938">
        <property type="entry name" value="Phage_holin_Dp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="72" mass="8059" checksum="6392C305F4E4C630" modified="2013-07-24" version="1">MRMCDKTYNVLKWMAQLLLPAMGTLYFALASIWRLPYGEQVVGTITAVDTFLGVILGITTAQYKQKQKTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAL4</accession>
    <name>R7IAL4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000095">
        <property type="protein sequence ID" value="CDE48313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48313">
        <property type="protein sequence ID" value="CDE48313"/>
        <property type="gene ID" value="BN770_01640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447739" evidence="1">
        <location>
            <begin position="24"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="205"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="370" mass="40457" checksum="8B0FA185598BA4A2" modified="2013-07-24" version="1">MKKTWIALLLALCMLTTIGAASACCTSACCTKPSGTDEAQTMEETCTCIIDGKTMDDCACMTGMCDEKCSCGEKCDCAEKKLEMLTAEMNAVFEKNMDLWNRFFGMMDKQPDMNMSYADYLTEQLELKKEKFTEDEYKLLQQDIETIRRLDEEMESLMPKDDVTAGSDVALESGVVTAGGGIVMGGEGMMMTDGSMDDKDMRVEDDSAEKFPAFEGMDLDGNPVSNELFKENSVTVINFWFSACAPCIGELGELNALNEELKLKGGAVIGINADTIGGDESMIMEAKNILEKKGAMYQNIYFPADSEAGKLTYSITAFPTTVVVDRNGNMVGEPILGGINSERQMTKLQALIDEALARNAKNMLVEPEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAZ4</accession>
    <name>R7IAZ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="11" type="ORF">BN770_01916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49079">
        <property type="protein sequence ID" value="CDE49079"/>
        <property type="gene ID" value="BN770_01916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="141"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="372"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="440" mass="49025" checksum="B93562B4DA1ACA52" modified="2013-07-24" version="1">MTKLKVGMISLGCNKNRVDSETALGLLREHGYELTNDPAQADVLMVNTCGFIASAKEESIDAILDMARYKQIGKCRVLVVTGCLAQRYEKDLMQEIPEIDLLMGVNQYQQLPDALEKALGGVRKSYCMDDHTYYAHDRVLTTPSYTAYTRIGEGCSNCCTFCAIPKIRGPYRSRPEADILREIESLAKQGVKEHILVAQDTSRYGMDFGGGSKLAELMQKAAKIDGVDWLRVLYCYPEETSEQLLDIIANTPNICSYVDLPIQHVNDAVLKRMHRRGTSADIRRAVKGAHERGITLRTSIIVGFPGETEEQFQELLDFLPEAEFDRLGAFTYSPEEGTPAAKMPDQIPEEVKAERLDRLMKRQAAIARKKNQARVGTVEKVLVTDRNARGEILGRSQREAPETDGEIIFTAGESKMPSVGDFVDVRIEKASTYDLTGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBB0</accession>
    <name>R7IBB0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_01808</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48751">
        <property type="protein sequence ID" value="CDE48751"/>
        <property type="gene ID" value="BN770_01808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="371"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE48751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="512" mass="55851" checksum="A8CE685ACE4F6BCF" modified="2013-07-24" version="1">MAKKFAAWWSAHKPTTRRLIQVYAALLYNAYVKGFIKGDIYTGSIKNFCVPGFNCYSCPGAIGACPLGALQNALASSDKRAPYYVLGILMLYGLILGRTICGWLCPLGLIQELFYKIPTPKVKKSRFTHALSYLKYVLLAVFVVIIPLAYSLQQYPVPGFCKYICPAGTFEGAMGLLANPVNAGKFSILNILFTRKFVIMVAILLACVFFYRAFCRFLCPLGAIYGLFARVSILGVKVEKSKCTNCGRCVAHCKMDIRHVGDHECIHCASCVDVCPTKAISMKMGKITLKANEVQPVKPGEEPQLEDNKKRTNRRIRVMAAWTAALVVLGVVMWQVNKADTVEEPASQPAATETLAPEATEAPADDTPVGYEVGMKCPDFTVPLYGEEGGEFTLSAQKGKVTVINFWATWCTPCVAELPYFAELYAKYGDEISLVAIHSNLVTDDVDKFLAKESLDMPFALDKTGAVIKSLGGSTQLPMTVIVDAAGKIVYNKVGSVTLTVLEGLVAPLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBH8</accession>
    <name>R7IBH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48945">
        <property type="protein sequence ID" value="CDE48945"/>
        <property type="gene ID" value="BN770_01877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="173" mass="19890" checksum="31AC2BEEC6EA234A" modified="2013-07-24" version="1">MIEGKRIRLRAFEGTDAAANHEFVNDPETLRGMMSGIPFPSSYADEQQWLSQQSSYTRGEYQFAVETVDGDELAGRCGIIRVDWKNRMAKLAIMIGKPYRGKGYGKEAMELLCDFCFREMNLHKLRVSVFAFNEAAERCYLSCGFREEGRLEKELWRDGAYRDVLILSRFADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBQ0</accession>
    <name>R7IBQ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000074">
        <property type="protein sequence ID" value="CDE47932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47932">
        <property type="protein sequence ID" value="CDE47932"/>
        <property type="gene ID" value="BN770_01440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447771" evidence="1">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="132" mass="14821" checksum="9A7B353890BE985F" modified="2013-07-24" version="1">MKALQRGITTILVLVLLLNCAFAAPIATYGDSIFMSASCFIFADKLASFDFTTYDIKERIVIVNVWLEQQVNGQWVYQKTLPVPAKVATDTVSYCVEYDYSSNITGRGTFRLGFTADADGYRITRYSPGRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC52</accession>
    <name>R7IC52_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000138">
        <property type="protein sequence ID" value="CDE49170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49170">
        <property type="protein sequence ID" value="CDE49170"/>
        <property type="gene ID" value="BN770_01928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001887">
        <property type="entry name" value="Barnase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00117">
        <property type="entry name" value="BARNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="185" mass="19957" checksum="337164D63730D537" modified="2013-07-24" version="1">MSEQKNQQKQPPKRATSGIFAILMALLLFLLGQQGILPLGDTADAPDSLPTATIAAALTDSPTSAPTQAPQQTAINAPQDIADYIFAHGTLPDNFMTKSEARQLGWDSSQNYVSDVAPGYSIGGDKFGNYEGLLPDASGRKWYEADANYTAGSRGAERILYSSDGLVYYTNDHYQTFTEMHPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICQ1</accession>
    <name>R7ICQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49664">
        <property type="protein sequence ID" value="CDE49664"/>
        <property type="gene ID" value="BN770_02084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="373" mass="41128" checksum="D28360F12D76B5F5" modified="2013-07-24" version="1">MAAITIKNMDVTYNKGKSYVIKDMNLEIKDGEFCVFLGPSGCGKSTAMYCIAGLLHPVHGEICFGNEAMNQLDERGKEKKFVPPQERNIAMVFQEYALYPNMTVRKNMSFALETKKAPKEEIEKRVNSMSAMLGLDELLDRKPAQLSGGQRQRVALGRALVRDPQVFLLDEPLGNLDAKLRDQVRYELKKIQTQLGVTTIYVTHDQTEAMTMADHIVLMKDGHIMQQGTPNDLYAHPNSLFVASFVGTPQINKLTCKVVEKGGSLAFQCGELLLSVPDDLTALMQQYKGKEVIVGLRPSELTLAPEGQGEIEGTVDSVEPLGDGFIVYLKAAGQMLVAKIAGGSTVIGKTISLNIEKGKFHIFDSQTEERLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID23</accession>
    <name>R7ID23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49316">
        <property type="protein sequence ID" value="CDE49316"/>
        <property type="gene ID" value="BN770_01966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="270" mass="29155" checksum="626B7512CCF831C3" modified="2013-07-24" version="1">MTRAGRKTDAATTLLMVLLILTAVKLLLERLLALMLPHDLHQNTRLLLSMAQEALLIGLPALLMRRGRSARTGTMRLSIGLLLCAAVLGLAMRALATPLTQLWGNFLSAPERQIAAADSAGEWCLQLLALAVLPAVLEEALFRGVVLQTLLDSGSRFGAWLLTTLFFSLLHGNLAALPAHLLFGGALTLAEMRTGNLLVPMVMHAVYNASALFWRGMSAGWLIFCGAAVLALGIWALMTLPRTAKMRMKRGHIMLSAAILLLMAVQYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID97</accession>
    <name>R7ID97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trk system potassium uptake protein TrkH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_02007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49416">
        <property type="protein sequence ID" value="CDE49416"/>
        <property type="gene ID" value="BN770_02007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006247">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006247-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="482" mass="52191" checksum="95F43426B6B2DC87" modified="2013-07-24" version="1">MNKRLVAYMQGAVLLIEAACMTPALVIALFQQDGDAWALGATMLILIAIGAPLRFLVRPGERNLRAREGFLTVALAWIALSCFGALPFVFSGMIPNYIDALFESVSGFTTTGATVLENFDNLPQGIMFWRSFTHWIGGMGVLVLTLALVPQLSERTSHLVKAESPGPTLSKIVPKMGDTAKIFYIIYLILTILEFIVLMIAGMNPYDAAIHAMGTAGTGGFSNYAASVGAFASPVIDVTITVFMVMFGINFALYYCAITGNWRGIVKSEELRWYLGIFLTVTAAITVVILPQYGTVGNALRYASFQVASIMSTTGYATADFSLWPVAARMLIFMLMFIGACAGSTAGGMKICRIAMLWKQGVRSVRHTFQPRKVQVVRFEGKGVDDTLLRETASFAFVYIAMILIGAVLIAFEGKYDIETNLSAALTCVSNVGPGFNAVGPAGNFAGYGSFAKVVLSLLMLAGRLELYPMLALLYPALWRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDC5</accession>
    <name>R7IDC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49293">
        <property type="protein sequence ID" value="CDE49293"/>
        <property type="gene ID" value="BN770_01961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="26"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="236" mass="27039" checksum="1A0CE98043B4C723" modified="2013-07-24" version="1">MSKQPLPQMPRWDGPLSHPFYSHVVKRIIDFLFALILLIPGCIIMLPLAIWVKLDSHGPVLYKAVRGGYHNQPFYIYKFRSMVVGADKTGGCTALNDSRVTRAGKVMRRLKLDELPQLFNILKGDMSFVGPRPELLLYTTQYTKEQECILWVRPGITDRSSIVYIAQDEIVGTENPVENFEKYILPEKNRLRVEYALHQSFPLDVELFFETIGGVFGKAKKMADEKHKQGAKEPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDG4</accession>
    <name>R7IDG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49849">
        <property type="protein sequence ID" value="CDE49849"/>
        <property type="gene ID" value="BN770_02164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025745">
        <property type="entry name" value="Mrr-like_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14338">
        <property type="entry name" value="Mrr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="161"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33669" checksum="68DCF3F3154755C2" modified="2013-07-24" version="1">MPVPKYDELMKPLLMAVKDGQVYKIKDANAALAQQLNLSAEDLAEMLPSGRQTVYKNRVGWAKTYLKKAGLLDSPARATIVITEAGKKVIAENPDKIDSKYLEKFPSFAHFISLSNSANESDLTPMISRSPDLTPDDQLENAYKQINTTLASDLLSEILMISPYKFEKFVIDLLSKMGYGTVAYGSHATAASGDDGIDGVIMEDKLGFSLIYMQAKEWAPDRVVGQPEIQNFVGAIAGKHGDGLFVTTATFSKKAKDYANTHHIILIDGEKLANLMIEHNFCVSTRKTFEIKEMDTDALNEYQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDM7</accession>
    <name>R7IDM7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acetylhomoserine sulfhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48677">
        <property type="protein sequence ID" value="CDE48677"/>
        <property type="gene ID" value="BN770_01786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="71" mass="7476" checksum="A971B2711BDE3F50" modified="2013-07-24" version="1">MKRLTLAAIETHVADARTCCLNPATSTHRQMTEEQLAVAGIPAGMVRISVGLESKDDLIADLAQALSGIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDN1</accession>
    <name>R7IDN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L1 and related esterases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49418">
        <property type="protein sequence ID" value="CDE49418"/>
        <property type="gene ID" value="BN770_02008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="42"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="207" mass="23448" checksum="B7F73ED91E87A509" modified="2013-07-24" version="1">MAKQDKIIRYRQLNQTAQKGQIVFAGSSLMEMFPIEQFVAEDNLPVVVYNRGIGGFVTDELLTNLAVCVLDLAPRMLFLNIGTNDLSDASRPMAQIMGTYRAILEKVLQALPDVQIYLMAYYPINEEAATPEMKPCLRVRTNEKIAQANAEVQKLAKSLHLHYIDVNAPLKDEQGRLRAEFTYEGMHIRPEGYRTIYPAIKKILMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDQ1</accession>
    <name>R7IDQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000118">
        <property type="protein sequence ID" value="CDE48702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48702">
        <property type="protein sequence ID" value="CDE48702"/>
        <property type="gene ID" value="BN770_01790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="346" mass="39558" checksum="57BD6299A716C576" modified="2013-07-24" version="1">MQLIRMNPLAFRKEPVELYSVTHTPNGSFVVIYFAEGEKTELQEMWMELFDSVGTSLLSAKLGEFDPNGEKIPHGQIILKKDRFICEYYPDITSMEVCTQTVYRYTGKRIQKPTTKKLKFGAAPYAQHVGDYMVEKQAHSEDETPFRTVKITHIASGKSKKLMIYDWSFCACSDQDGNLLIAQQNEKGNLEIRSYNAAMQESIVELSGDFLQNENVRDAACIGQTAYMRIRLTNEKSEILLYDITQQKITDSQTLLAVDDNSYIAEIKAAGAVLLSVDGYWNRELQRQKYQINLLNEHFETSRLPLQHESCLYIFTDVEQADVTTIEMDEKSHSYFVCSYSISAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE04</accession>
    <name>R7IE04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50059">
        <property type="protein sequence ID" value="CDE50059"/>
        <property type="gene ID" value="BN770_02260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="86" mass="9889" checksum="419332917F686721" modified="2013-07-24" version="1">MKIIRNIDGKKLELTLTNEEAMIQANIKAVQRRYVEGESLFTMRRGKIAQGQDVNDEEYFENSFFVTVLESLLTEHPEIIGTKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE67</accession>
    <name>R7IE67_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dak phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49716">
        <property type="protein sequence ID" value="CDE49716"/>
        <property type="gene ID" value="BN770_02099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="550" mass="58964" checksum="8CA64908F012E545" modified="2013-07-24" version="1">MIQHKTIDGLLLRDMVVAGAALLEKNREAVDALNVFPVPDGDTGTNMSLTMQSATREVNAQEYLRADEAAAAISKGALKGARGNSGVITSQLLRGFATSLKGVEKITPVQFAQALKAGSDKAYKAVMKPKEGTILTVARVIAEDAIKYTESNPDDYDGLMNVILTSGEAILKRTPDMLPPLKAAGVVDSGGRGLMLIYTGYAAVMRGEEIADPAALLAGDSQVEEDIHDLSGDLPYAYCTEYDIVNFREDCTEGDVDSFRRRLNRIGNCVKVTGDLTETKVHVHTNDPGNAIQYGIELGELVNVKVDNMLARKRALEAEKAPAAVEAPAEPAKEFGMVAVSLGDGFSSIFRDLTVDVVVEGGQTMNPSVDDILNAINQVNAKCVFVFPNNGNVIFAANQAAELAEKEVHVIPTKNVAMGIAAAVAFQDDVSGEENAKRMAEAAEHVKTGTVTYAVRDSEYNGVQIHKGDIIGMHNGKIEYCGNSVHDVVLDMMKAVVTDDAELITVYYGADTTKEDAEQVAAEIADQYPNCDVDCLLGGQPLYYYLISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE94</accession>
    <name>R7IE94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000123">
        <property type="protein sequence ID" value="CDE48897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48897">
        <property type="protein sequence ID" value="CDE48897"/>
        <property type="gene ID" value="BN770_01854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="139" mass="16058" checksum="93A0AB337D7126E4" modified="2013-07-24" version="1">MLDATLDMDGAAVAAQIEKIHHEYTSVIQYHNENSLSSVLTIAYLSAMQYYFKPIRELPTGRGFADFVLVPKPECRNDYPALIVELKWNQNAQTALQQIREKNYPASIWDYTGEILLVGINYDRDSKQHQCLIEKYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEG7</accession>
    <name>R7IEG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49718">
        <property type="protein sequence ID" value="CDE49718"/>
        <property type="gene ID" value="BN770_02100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="116" mass="12860" checksum="4F91C5615422FCD6" modified="2013-07-24" version="1">MDCKIKNDIGTIYITEDVLLKVVGYAALECYGIVAMSSKRAKDGIVEWLGRENLSKGVQIRSVGDMLDVDLFIIVEYGISIAEVCKTIVDTVRYKLESMTGVKVRKVNISVEGIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEZ9</accession>
    <name>R7IEZ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50026">
        <property type="protein sequence ID" value="CDE50026"/>
        <property type="gene ID" value="BN770_02237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12358" checksum="DBAD1B704851AF55" modified="2013-07-24" version="1">MYISNIDHQKVQALTALVNVMPGQIVSRTLAQNKAVSITLFAFDKGTEISTHESTGDAMVQVLEATGCFTVDGKEYIVHPGEVLVMPANVPHAVSAPEAFKWVLTVVFPEGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFC3</accession>
    <name>R7IFC3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50161">
        <property type="protein sequence ID" value="CDE50161"/>
        <property type="gene ID" value="BN770_02305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025373">
        <property type="entry name" value="DUF4363"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14276">
        <property type="entry name" value="DUF4363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="127" mass="13927" checksum="718D14908E2810E1" modified="2013-07-24" version="1">MKTGVWISLILLAMTIGLGVWSGEEVRALSEEYAASAEELRTLAEAENWAGAEASLQKCQSVWKQKVPWLQTLINHDDVDAVTTALKKIEAGISSRELPLCLEACAELGEHAEHLYHRDALTLGNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFG7</accession>
    <name>R7IFG7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="7" type="ORF">BN770_02440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50554">
        <property type="protein sequence ID" value="CDE50554"/>
        <property type="gene ID" value="BN770_02440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="132" mass="14203" checksum="1A75A7C2841978F1" modified="2013-07-24" version="1">MVVNDPIADMLTRIRNAQVAKHEAVTLPASNTKKAIAKILLAEGYVKAVDYIDDGLQGSIKVTLKYINGKTPVIAGLKRISKPGLRVYARCEELPKVLGGLGIAIISTSKGLMTDKEARKNAIGGEVLAYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFI9</accession>
    <name>R7IFI9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50375">
        <property type="protein sequence ID" value="CDE50375"/>
        <property type="gene ID" value="BN770_00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="71" mass="8142" checksum="A71F2B06A3097B26" modified="2013-07-24" version="1">MNAVKIGMTIEEAAECTGIGRNTMRKLVDWGKLPVLKVGRKTIIRRDTLERFMTVNQGRNLLNQNDVRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG30</accession>
    <name>R7IG30_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6 8">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplP</name>
        <name evidence="10" type="ORF">BN770_02447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50585">
        <property type="protein sequence ID" value="CDE50585"/>
        <property type="gene ID" value="BN770_02447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="146" mass="16323" checksum="16F8CF96AF2930C7" modified="2013-07-24" version="1">MLMPKRVKRRKVFRGRMKGAAHRGNFLAYGEYGLQATEPCWVTSQQIEAARIALTRYTKRGGQVWIKIFPDKPVTEKPAETRMGSGKGSPEYWVAVVKPGRVLFEIAGVPEEAAREALRLAAHKLPLKTKFIKRADEAVTEAGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG43</accession>
    <name>R7IG43_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50278">
        <property type="protein sequence ID" value="CDE50278"/>
        <property type="gene ID" value="BN770_02341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="176"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="248"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="33581" checksum="B3563A3CF7FE75C0" modified="2013-07-24" version="1">MRQDYLLVSADATGTIGYVSHAGYLNLRREASTSAKVLGKYDDGTPCVILDRAGDWYYVSVGGQTGYFLTRFISTRSGVYSDKLGMVISPNKENVHLRSGPGKNYGSLASIPGCTYVMILQQGNGWWKIAVNGGVGFMSTDYLRAGHIRRSEGEALCAKAAGSSASSGSSSTAQQATYAVVNNPNPRDKLNLRSRASTRGTSLGKYSNGTVVTMISQGDQWCKVKTPDGKTGYMMTDYLSIPSASSSSSTRIVRHPQGTYVNLRSSGSKSARVLVQVPHGSTVVVLSAGKTWTKVRYNGYTGYMMTAYLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG56</accession>
    <name>R7IG56_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50610">
        <property type="protein sequence ID" value="CDE50610"/>
        <property type="gene ID" value="BN770_02457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="236" mass="25248" checksum="9329433844E6A610" modified="2013-07-24" version="1">MIRFETVNELALKVTCQGGGVLYTKAGAFIAGESAGGKNYTFEKVLFGPQQGLLQAAFGALTRRMAGENLPLMKVNFGGDSQTYYANAGQHVTAYQLARGEVLSVEAENILAFTGDCDYNVRFLGMGVVSQKGIATSTLTGRGDSAYVAVLSDGNPLVMNNRKSRATISVDPDAVICWMGQEGDNCDPQIRTDINWKTLIGQASGESYAYEWGGNQPVTVIVQPSERKGGIRLAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGB0</accession>
    <name>R7IGB0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50353">
        <property type="protein sequence ID" value="CDE50353"/>
        <property type="gene ID" value="BN770_00171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="418" mass="46882" checksum="3A024066E49B784C" modified="2013-07-24" version="1">MNTDVLFDRAFAIRAAKPWQHLFDTHIFAVRFSDGEIACCSVMGRNGTHLALALYSLTDGLYALDKLMTTDMRVLPRHRAEECMLGQDCIQVSFENAQEILAKEAKAVRAYAKAHGISLRGQHNFPVFHRYRPSRMPWALTDETEQQHLLEAMDALLEISRRLNTEEPLALGLIEGDPFTHPIPLLTATPDGYRWDSYTLQKPDAPALPTGKIEDELALARLKKRKKPCAPWALAVFMSPTPVQAKPAQVPYFPYLLCVVDTGSGKMLTLTPPRKIDEYAPHFSADFLPLLQQHGLPREFWSADDRTTAFITPIAKQLGIPVNVQADMTPMDELLDELYDHLNDASFEGADEMGNAPDDAEVLRLLAAHIADAPETLRAIPDYMLTEIRAAIAALPNSRDALRALDEEIKRRRLPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGP5</accession>
    <name>R7IGP5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000186">
        <property type="protein sequence ID" value="CDE50984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50984">
        <property type="protein sequence ID" value="CDE50984"/>
        <property type="gene ID" value="BN770_00257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="154" mass="17511" checksum="EE8A64016D2A4EBF" modified="2013-07-24" version="1">MPKNKFQDVVLTAIMATIMVYGMVVYNVALATGGLTAESFLLALYELPIMVPIAFVLEFFAVGKIARRLAFTVMRPTDRPQFITYAISICICCIMCPLMSLVATILFKDTKTFATWVQTWAMNFPMAICYQMFYCGPLVRLIFRAIFREKQQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH48</accession>
    <name>R7IH48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50940">
        <property type="protein sequence ID" value="CDE50940"/>
        <property type="gene ID" value="BN770_00249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="127" mass="14702" checksum="4ED3CE6C85BE136C" modified="2013-07-24" version="1">MRILIRKSYDLQVRQAENRRLCGNCYCKDYEGYICINEMGYLLNPNRVSAMFELTLQQNPLRHIRFHDLRHSSASLLLANHVPLKQIQEWLGHSDFSTTANIYAHLDVASKQNTAEAMLHGLGLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHA7</accession>
    <name>R7IHA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methenyltetrahydrofolate synthetase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50821">
        <property type="protein sequence ID" value="CDE50821"/>
        <property type="gene ID" value="BN770_00219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="PTHR13017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="251" mass="28452" checksum="E3DB0F03BAF22A73" modified="2013-07-24" version="1">MMEKKLDAKEARVQIWEELLRVAKPDSKFSWQFSEFICDYEGSEKGTALLTATDMYKNARVIFITPDNNLETLREQAFRDKKTVVMTNYGITRGFFLIRPGQIPEGKEEIASLLDGVSRYWKHQTLAQLKEAVGHIDMMVTGASAITPSGIRFGKGHGYFDLEYAMLSTVGLCDETTAIVGAGHDVQVVDVDVTVEDYDTAIDYIVTPTRLIETRHEYPRPSKGIIWSRLAPGMREQIPPIQELWCKVHCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHH4</accession>
    <name>R7IHH4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50052">
        <property type="protein sequence ID" value="CDE50052"/>
        <property type="gene ID" value="BN770_02253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="236" mass="27108" checksum="5A1A486C04BE0AE3" modified="2013-07-24" version="1">MFVDIHHHLIYGVDDGAQTWEDTQKMILRAVDEGITDIVCTSHATPGITPFPTEKYLAHFAQAQQWCRENQLPVTLHTGCEILYTDASPHLLKEGHYPSLAETWTVLVEFSGDVPYSRMCEAARLFGNAGFTVIFAHVERFDPMRNFKHVRELREEYGVYMQMNANTVLMKKGFFADRWTRKMLDEGYIDCIATDAHNTTSRPCRMRECFEKLKASYGVEAAEELCGGFQRRLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHL0</accession>
    <name>R7IHL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000205">
        <property type="protein sequence ID" value="CDE51249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51249">
        <property type="protein sequence ID" value="CDE51249"/>
        <property type="gene ID" value="BN770_00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029078">
        <property type="entry name" value="Imm44"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15571">
        <property type="entry name" value="Imm44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="132" mass="15295" checksum="1B6F6C6A5BC59441" modified="2013-07-24" version="1">MSAIFLSTESQSPAAQMIIDCFIEIQQNMDIVSLDKYTDAISTISIIPFCVDEEFKNTFACKERKYIGWKRKEADIRLFIPFIPFVQASKEEKLSICKEIIKKSLTEIHARCMVKKVRFDLETLLCDIFPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHM0</accession>
    <name>R7IHM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50798">
        <property type="protein sequence ID" value="CDE50798"/>
        <property type="gene ID" value="BN770_00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="242" mass="26536" checksum="33189BDD2B81EAFB" modified="2013-07-24" version="1">MRAVFRHELSGYFTTPVGYVFLTMYALLSGLVFVFINIGQEMSASMNLLFSGMQLPLMLIAPLLTMRLFAEEKRMRTDQLLLTSPVPLGQIVLGKALASLALLMIAMLLSLIYPLLIAPYAQIAWSEIAVVFLGYYLLDAAMVSVGVLLSSLCTNQVTAAILTLGVNVLMYLSEHYIVPQAGTSAYLHPVSVILSFLPSSARLGDFANGIVSLSDIVYFVVFTALILFLTDRAMEKRRHAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHM8</accession>
    <name>R7IHM8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_02281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50107">
        <property type="protein sequence ID" value="CDE50107"/>
        <property type="gene ID" value="BN770_02281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="347"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="414"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="482"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="629" mass="68708" checksum="BBF8CE06200A3EC2" modified="2013-07-24" version="1">MNALIQPGRILAGRYRIDQQIGVGGMAVVYRATDLNTQHFVAVKVLKPEYNQDAEYVARFQREAEAASKMTHHNIVNLLDVGMDSSGNRYLIMEYVEGQTLKDVIREKGRLSETSAVQITIRILSALQHAHSNGIIHRDIKPQNILMQSDGHVKVADFGIARMANKNTLAKGDSVMGSVHYFSPEQASGKEAGVTSDIYSVGVTLYEMLTGRVPFDSNNPVAIAMQHIHNTPVPIQQYAPETSDAVCHVCMKAMDKNPAYRYQSAWDMARDLRHAISGQVGEMEPRIVDGRLPGDGESGGMQPARRQPSRRMVRKKHPASWWVITLLMSLVVCYGLFVGTKAIYERVVNSAVVDEYTGMDVSAAQRQIQRAGLRPEIMEINHPTIKAGEVILQAPQEGTTLRKNDVVVLTVSKGPSTQTVPKITNLTVSDAITTLSPYGLTLTIVEYVVSATVPAGRIISQSPEEGSVCMSGDAVSVSVSGGMAVVPNVYGRHLADAQELIAASGLSLNQNITFLETDDTTMHGLVAQQSPSGGSEVIASAKVSLTLYRVPSMMARAKVLLSLPQTESMMHVRVTLVESGVEYTAYEGDFPANASREPEVELCGNEPGMYTYRVYCDGEFAYQQQVNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHV7</accession>
    <name>R7IHV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50172">
        <property type="protein sequence ID" value="CDE50172"/>
        <property type="gene ID" value="BN770_02313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="106" mass="11827" checksum="32F541E6D6709E5B" modified="2013-07-24" version="1">MTEKELRKLGRAELLELLLEQAREFEALEQRLNAAEAALQSRQLQLETCGSIAEASLKLNGVFEAAQKAAEQYQQNVERLCQEKISAAESQAQEILARAKKAANQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7II75</accession>
    <name>R7II75_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50262">
        <property type="protein sequence ID" value="CDE50262"/>
        <property type="gene ID" value="BN770_02340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="131" mass="14540" checksum="1505428BF11960DF" modified="2013-07-24" version="1">MAEAEEKLEVEGCGFLCVHEKVVEKVQHELPQEETLLRLADLFKVFGDGTRVRILFVLLTAEVCVCDLAKLLGMTQSAVSHQLRVLKQARLIKARRDGKTVFYSLADDHVATLLRQGMEHVCEGSGGECGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIC6</accession>
    <name>R7IIC6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50327">
        <property type="protein sequence ID" value="CDE50327"/>
        <property type="gene ID" value="BN770_00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="81"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="374" mass="42570" checksum="0EEACB0770222E91" modified="2013-07-24" version="1">MKISKKDALMWFRFFAELPEDEPLMPHQQELAWAVISQIETAVDARHKELMAQIPDLHTLGGRTYFVGDPAKFSKGCTSCLTGTGLSAIRRTNKCNIRCPFCYNYGELDCQETIGEGLWEIGGTYFRVEDIDLLLSTSNRPTGVSYVYLEPFMEIELYPDIIRKFRAAGIHQHMYTNGTLCTEENLRALGEAGLDELRFNLGATSCADNVIQSIATAKKYIPTVAVETPMTPDFYEHFQQKKDAILATGLDFINCAELHLNPNNLPNYIGTPMYMTRRGYVSPIWSREITFRLMRQCAVEHWGIVVHDCSNHTKFARDLNLRAKEGGWFGASSYHSEFDQIPFEAFLPTLEDSDFRFLEEEPLPKGYRPGDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIH8</accession>
    <name>R7IIH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51594">
        <property type="protein sequence ID" value="CDE51594"/>
        <property type="gene ID" value="BN770_00509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="180" mass="19730" checksum="644AB3FC05E7C3A8" modified="2013-07-24" version="1">MTKEWEKPEDLRRRKPVLWLTMTALFMAMVVVLSMSALSIPVPGGHLYFNDVVIDTAAMLMDPLSAFIACGVGAFLGDLLFYPAPMFVSLITHGLQALVISLLCRKLRMKQPLACAIAVLAGAIVMVVGYTLGRAFVYSTPEYAIMKLPFQCLQAGVGAVTSWILCCPLGLTRRFRSIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIL1</accession>
    <name>R7IIL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51286">
        <property type="protein sequence ID" value="CDE51286"/>
        <property type="gene ID" value="BN770_00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448007" evidence="1">
        <location>
            <begin position="21"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="482" mass="52456" checksum="DDDFF2119D02BFDE" modified="2013-07-24" version="1">MRKILSLLLMLALFLPCALAEAPQGIDLALTSTYGDGLSLRMTAGLSETPFCSLTLPSGQIDLAFSPDKGLCVQSGGQWAQLLVEGHPVDAALLTTPLKLLDGRSPSEALGLLAEDVNKMLDAIPSLYNLPMTLIRDPAFARLFSDLYIAAQTGTISITSEELNRLAASVLGKIYSMEYLDGLNFSDIYHNLLASVVQTSEVARAYRSAMRGYLLSNFRLSGQIGIDKGELLFSQPYQEPYHLTYEQTTPNSWHYLLTTANSDTIDGVLYWRNEYDFALSGYSENQHTAFSVTCSYGSANNFVFIASVDNSFSLSIVQAGSNFSLRLNNENANVFALNANVFSLESTSDYIRVKIYYNYYTLTITPATDGLDIVAQARTFDIFTAHVRTALNGLICTGVYGDTTYRLALTETATGFSLLLSLPDGDFHLDFAALSDTSCSLTFTDAAGQQVSLTGSLCTPESPVIPDAIGTIELTQLLDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIV9</accession>
    <name>R7IIV9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation initiation factor IF-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50537">
        <property type="protein sequence ID" value="CDE50537"/>
        <property type="gene ID" value="BN770_02430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="53" mass="6178" checksum="D5CF3DE7C5C8F45A" modified="2013-07-24" version="1">MFKVELPNGHIVTAVISGKMRMNFIRIYPGDKVKIELSPYDLNRGRITWRSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIW2</accession>
    <name>R7IIW2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50542">
        <property type="protein sequence ID" value="CDE50542"/>
        <property type="gene ID" value="BN770_02431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06088">
        <property type="entry name" value="KOW_RPL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041985">
        <property type="entry name" value="RPL14_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="111" mass="12395" checksum="1F907BA861A481B9" modified="2013-07-24" version="1">MNRLTMEPGRVVQSTQGRDAGRYFVVLQVVDDRHVLMADGQSRKIDHPKKKKMMHLRPKPIVVNVEPQALENKHLQDSDLRKALSAHGLSLKAQNEQPHAEAAAAGADKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIY5</accession>
    <name>R7IIY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51441">
        <property type="protein sequence ID" value="CDE51441"/>
        <property type="gene ID" value="BN770_00441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="73"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="370" mass="42345" checksum="7AB3D582D9F0BA78" modified="2013-07-24" version="1">MSKVLLITNIPAPYRVDLFYYMQTHQQTHEFFVIYTNRNEDNRQWVIDERKLLQSTILESKIIKRKGEGDVHYLHIPQHLTREITRINPDVVIAWEYNPSALKALLWCKRHGRKFIHLTDGTLHSDRNIGRVQKLMRHIIIHHADACIASSTKAKEKLLHWGAPERKIFLSPLTVDISRFRYAEKHENQHTLLFVGRIIPLKGLDLLLRALPKLHQPFELLIVGDGEAEEKAKLMAMAEETHVAQHIHWLGFQSGEPLADAYRRASVFVLPTREDCFGLVLLEALCSGTPIVASKYADGAYDTVHPGENGLIVDPEDTDALAEAIDSILSSEEIQRRYSQNCRQYIPQFEFEAVMQGYLQAIASVTSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ08</accession>
    <name>R7IJ08_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="CBJB010000207">
        <property type="protein sequence ID" value="CDE51263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51263">
        <property type="protein sequence ID" value="CDE51263"/>
        <property type="gene ID" value="BN770_00350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="148"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="34131" checksum="6BF50FB7F0144F85" modified="2013-07-24" version="1">MKHLLKLLDLSKEEITELLDLADRLKAETKAGVEHHILKGKTLGMIFEKSSTRTRVSFETGMYQLGGHALFLSSRDLQIGRGEPVEDTARVLSRYLDGIMIRTFAQEEVETLARVGSIPIINGLTDFCHPCQVLADLQTVREYKGRIEGLNMCYIGDGNNMANSLIVGFLKMGAHVSIACPKAYQPDAQVLSFTEQYPGKFVMTESPEEAAKDADVIFTDVWASMGQEEEKAVREKAFRGYQINAELLAKAHLGCMVQHCLPAHRGEEITADVFESHADQIFDEAENRLHAQKAVMVAVMADKKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ96</accession>
    <name>R7IJ96_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51834">
        <property type="protein sequence ID" value="CDE51834"/>
        <property type="gene ID" value="BN770_00644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018770">
        <property type="entry name" value="ChloroindolylP_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10112">
        <property type="entry name" value="Halogen_Hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="288" mass="32578" checksum="D9947EA4DA3E88E2" modified="2013-07-24" version="1">MSKSKKKKETKAVIAGQIAFWVSFLGIISLPIPGFWRFVGGFAIASGLKKLIETMATPLDGLHTENGERVKEEPVIQVGTPEDQRAKEVVAGGLDLLSQIAAEREQIDEFVMTRRLKDLDELVRKMLQTVVDDPNEASRMRKFMSYYLPTTLKLLQSYRTMKTRGVSYSEMNTTRENLIHALDMILQAAQKQLDAMHKDDMLDMSADMDVLEQMLKRDGYMESVLSESLKEANRQQQNASVPYSTQQADLHTSGTAAARQMNQGAPVLKMPEEDIPEADRQQKKFYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJC6</accession>
    <name>R7IJC6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51869">
        <property type="protein sequence ID" value="CDE51869"/>
        <property type="gene ID" value="BN770_00662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="350" mass="38824" checksum="A540ED7D7C3F4F96" modified="2013-07-24" version="1">MRLIVADVRSTSTDGIAAGHYFTVAQNYLDLFGAEMDVRIAGGPVYGDRFGNKLIRLPHDYIVGSSAARNKRAVFQNVRALLREAQDDVIVLQCSAVATAYLGLALFKKKETRVYAIQYSTDGVNSVLKRGLYALCRWKISGVICPNAAIGAAYGRPMCVVSDYISTGTMQPPVPYAQKRYDFGMVGLITSDKGVVEAAKQLRNTPYRVLIAGRVQEAPLEAELRAVCAGAKNIELRLEYLSEAAYDEAIRQCRYCILNYSENYSLHSSGVVFDILFRGVPIVGSRCGTLQMVEANELGKTVSRMADFAPERLLDEAVHDRYVRNIARYCQSQAQEREKLRDFLTRGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJC7</accession>
    <name>R7IJC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC superfamily ATP binding cassette transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000218">
        <property type="protein sequence ID" value="CDE51408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51408">
        <property type="protein sequence ID" value="CDE51408"/>
        <property type="gene ID" value="BN770_00420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="50"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="271" mass="30248" checksum="6694168B6168F7D4" modified="2013-07-24" version="1">MEWNGGDISNAHFVGLQNFAEIFKVDKVASKWANGDYLYFFNRVDLGIALKNTVFYALINVPLTLVCAIALALALNKAKGAVAFRTIFFFPYVASMVAICVCWNFMLMKDGPVNQMIMALGVNFNKSWTADSTMAMWAIILVSVWRSMGYYMVIYLAALQGVPRELYEAATVDGANKWQQFRNVTLPQIKPTTFFCTIMLVIGSFKIYDTVAIMTNGGPGRATKMLVTYIYDVAFNNIKYGQASAIAMVLLVIVLIVTIIQFANEKKFAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK19</accession>
    <name>R7IK19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51658">
        <property type="protein sequence ID" value="CDE51658"/>
        <property type="gene ID" value="BN770_00559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="141" mass="15855" checksum="42FE26AD9D5A09F5" modified="2013-07-24" version="1">MKDDLADNALDSLRDMGKEALQPMLENLNKANEAGQEALLDVLANFPGHENVYQLAVRLFEKNPNRRALFASYLAKLGDPRALPVLIAAANEENCRYMDFIELRAAIEELGGEAPEREFYDDPEYEALHPMDDGDDDTNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK58</accession>
    <name>R7IK58_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51841">
        <property type="protein sequence ID" value="CDE51841"/>
        <property type="gene ID" value="BN770_00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="251" mass="27502" checksum="40B976EBFB407B38" modified="2013-07-24" version="1">MPTKSCSSPRRSASNKRLRRTLGLLLGSALAVQYKQDRIFRASVNLQLVMVLNYLYAAYNLLIGLQSGSVWLLSLGIYTLMLAIVRTDLTLSHHRGRKLPADALPRHESRCYRRVAWSLLALNVPIGGLTLLMVSGQSVSALPGHLIYLSALYTFVMMFLAISNLIRFRKLGSPILSAAKVLSLVAALLSLLTLQSALIDRFGTAQGSFRLLMTRLTGSAVYASVLVIAVWMLCRPLTISADGIEEELTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKI8</accession>
    <name>R7IKI8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00744</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000254">
        <property type="protein sequence ID" value="CDE52006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52006">
        <property type="protein sequence ID" value="CDE52006"/>
        <property type="gene ID" value="BN770_00744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE52006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="819" mass="93732" checksum="464CFC7971D20535" modified="2013-07-24" version="1">MPTTSFDKDSIKASIIGKLQRYNGRTIEEASNGQIYRALASTVRDQIMQKWMISREERKTNNNKRLFYLSVEFLMGRSLYTNILNLVSLDAYKQALDELHIDVDKVLQEEPEPALGNGGLGRLAACFMDSLASLDLPAMGCSIRYEYGLFRQKIVDGQQVELPDYWLGNGNVWEMPVMEDACEVHFNGHVEMGNENGRTVFRHVGYNTVEAVPYDMPLVGYDTSTVNSLRLWSARAPKRIDLSDFNHGHYVQASEEKELAEAISNILYPEDNHYEGKLLRLKQQYFFTSATLQYILKDFKKLNGTNWSKLPEKVVIHINDTHPGLAIPELMRLLMDEEGLGWDEAQQIVSRTMAYTNHTIMAEALEKWPEDMVKSLLPRIYQILVEMNKRLCARLWNFFPGEAERVGRMAIIAYGYIHMANLCVAMTFSTNGVSKLHGDILKQETFHDFYLVMPEKFSAITNGITHRRWLMACNPELTKLICDTIGTDWVKDPELLHDLAPYADDAAFREQFEKIKHNNKVHLSNFLKEHQGAIVDPNFIFDAQSKRLHEYKRQMLNALHILVLYNRIVNDPNFTMRPRVFIFGSKAAPGYNRAKLIIRFINGLSALIAKHPRASKMLQVVFLENYDVSSAQLLIPATEISEQISTASKEASGTGNMKYMMNGAITIGTMDGANVEISEQVGMDNIYIFGMRSDTVLDMYRERNYNPMTIFETNQELRLALTQMIDGTVLPDAPSALQDLYHSLLIGDWGNMADPFFVLKDFGSYSMAQRRIDADYADRDKWNRMAVINTAMSGVFCSDRTIREYNDTIWHLDPLKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL20</accession>
    <name>R7IL20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family EDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000255">
        <property type="protein sequence ID" value="CDE52018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52018">
        <property type="protein sequence ID" value="CDE52018"/>
        <property type="gene ID" value="BN770_00749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE52018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="288" mass="31530" checksum="B509A25E6933D7FE" modified="2013-07-24" version="1">MYYIVTDSSTDMPQSWVEAQHDFHIVSLSCTINGVSSVPGTSEVAKKETYRQLRSGVVIKTSAVNTATWEECFQKLLDEGQDVLCITFSSGLSGTYAAAADAAKELAPKYPNQKIIVIDSRCASAGEGLLVHYALQNREQGMSIEENAKWVKEHIQHLIHWFTVDDLMFLYRGGRLSATSAVVGSLVRIKPIMHVDEEGHLAVVEKVTGRRRSIRILANRVKEHIVNPEGQMIFISHGDCEDEANALADIIKAEIPGIAGVLVTYVGPVIGSHSGPGTLAIFFLGDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL50</accession>
    <name>R7IL50_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell membrane</location>
            <topology evidence="2 6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000213">
        <property type="protein sequence ID" value="CDE51337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51337">
        <property type="protein sequence ID" value="CDE51337"/>
        <property type="gene ID" value="BN770_00048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030946">
        <property type="entry name" value="EcfA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04521">
        <property type="entry name" value="ECF_ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32381" checksum="DFDF562A54DB7BF3" modified="2013-07-24" version="1">MSLEVKHLTHTYSAGSAFQATAVHDVSLTIEDGEFVCIVGHTGSGKSTLVQHLNGLLKPTSGQVLVDGEDMNGENVDRRRIRQKVGLVFQYPEYQLFEETIAKDIAFGPKNQGLSEEEIDQRVRRAMAHVHLDYDKYAERSPFDLSGGQMRRVAIAGVLAMEPKVLILDEPAAGLDPRGRERILGMLQELHREGGVTIVMVSHSMDDCARLATRMIVMSKGELVLTDTPRNVFRQADLMRSIGLGVPEAAELCGRLRAAGLQLSDDLFTQEELHDHLLRLWKEKQEKEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL79</accession>
    <name>R7IL79_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_00402</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51372">
        <property type="protein sequence ID" value="CDE51372"/>
        <property type="gene ID" value="BN770_00402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="11">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="778" mass="83915" checksum="B50BA151AD100A93" modified="2013-07-24" version="1">MAITIALAGNPNCGKTTMFNALTGSRQFVGNWPGVTVEKKEGKLKGNDDVVIQDLPVIYSLSPYTLEEVVARNYLVNDKPDAILNIVDSTSIERNLYLTTQLLELGTPMVIAMNMMDVSRKNGDKIDMKKLSAALGVEIVETSALKGEGSVKAAEKAAAAAKNRTMGEHPHVFTGSVEHALAHIEDLIGGKVEPRFLRWYAVKLFERDEKVVAELKLSEDVKKGIEEAVSSCEKEMDDDAESIITNQRYAYINTLMQNAVKKGKAKGSLSVSDKIDRVVTNRVLALPIFALIMFLVYYISVTTIGTLLTDWTNDVFVAEIVQGNLQTWLDGVGCAGWLSGLIVDGIVGGCGAVLGFVPQMLVLFLLLAILEDVGYMARIAFIMDRIFRKFGLSGKSFIPMLIGSGCGVPGIMASRTIESDRDRKMTIMTTTFIPCGAKMPIIGLIAAAVFGGSAWVATSAYFIGVAAIVISGIMLKKTKMFAGDPAPFVMELPAYHFPSGRNVFHSVWERGWSFIKRAGTVILLSSIVIWFAKTYGWAPAADVQLEAQQTYQTELADYNAKAEAGTLEEDEEAPELAPEMDRAAGSWGAVADMDNSILGKIGNPVSVVFKPLGFGNMPSTVATVMGLVAKEEVVGVLGVLYGADDAADVVDDEDMTEEEKAEALSPIATAFNESSNGHGRLAAYAFMIFNLLCAPCFAAIGAMKREFNNAKWTLAAVGYQCAFAYVVALIVYQLGLLFSGAGFTVATAIAILLLAGLVYLVVRKNPYNDNHLTQKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILK5</accession>
    <name>R7ILK5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcriptional regulator CtsR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the CtsR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51507">
        <property type="protein sequence ID" value="CDE51507"/>
        <property type="gene ID" value="BN770_00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008463">
        <property type="entry name" value="CtsR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041473">
        <property type="entry name" value="CtsR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041908">
        <property type="entry name" value="CtsR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040465">
        <property type="entry name" value="CtsR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041902">
        <property type="entry name" value="CtsR_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40028">
        <property type="entry name" value="PTHR40028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05848">
        <property type="entry name" value="CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17727">
        <property type="entry name" value="CtsR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010607">
        <property type="entry name" value="Txn_repr_CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CtsR" evidence="8">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CtsR_C" evidence="9">
        <location>
            <begin position="77"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="158" mass="17674" checksum="EEA2753476A65885" modified="2013-07-24" version="1">MRLSDSIETFIKTLLAEDEPEVELKRNELAEYFGCAPSQINYVLATRFSPDHGYLIESRRGGGGYIRIVRIVQSGAQQLMYLINERIGDAIGEEEASRLVQQLTEQKLVTAQEAALMRAAMSAQALAIPIPDSMKDAQRARIFKAMLTSIARQNRTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3B2</accession>
    <name>R7I3B2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusG</name>
        <name evidence="11" type="ORF">BN770_00001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the NusG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000001">
        <property type="protein sequence ID" value="CDE46130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46130">
        <property type="protein sequence ID" value="CDE46130"/>
        <property type="gene ID" value="BN770_00001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 7 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="9">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="10">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="181" mass="20407" checksum="DF6865A198D1C095" modified="2013-07-24" version="1">MSEKSNEACWYVVHTYSGYENKVKDTLEKSIKSSNMQDYIFDVRVPVEEVSEIRKGKRVKSTRKVFPGYVIVNMIKTNESWYVVRNTRGVTGFVGPDGQPVALTPSEVEMMLNPQSVGTACDLAIGESVKIVSGSYANFKGTVVEIDQMLGKVLVNVQMFANRTGEVWFNMEDVRKDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3E9</accession>
    <name>R7I3E9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000003">
        <property type="protein sequence ID" value="CDE46165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46165">
        <property type="protein sequence ID" value="CDE46165"/>
        <property type="gene ID" value="BN770_00761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="27428" checksum="98FE91F45C2182F6" modified="2013-07-24" version="1">MAKIVGLSRNLKLQWLNKVVELASSNLTEQEIKDQLNEYLSFEISSPTNLRKTREILMNIWVYENDISNKLREEAISIVRDMPEYALAAHWCMMLATYPVFVDMCKLIGRLSEFQDEITLSQIKQKLYDEWGERTTLYHSIDKLISTLKELSVLRCEKPGKYHIVKHEVHNGRISAFMMYAMILVDDSGYYSFTDLSNSVYFYPFQYQLEKKLLLGDDRFSMNNFGGELSVSVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4A4</accession>
    <name>R7I4A4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46475">
        <property type="protein sequence ID" value="CDE46475"/>
        <property type="gene ID" value="BN770_00887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="472" mass="50324" checksum="FE27AE412ADD8E6D" modified="2013-07-24" version="1">MQTESETSIAQNARPLATQPLGRLMRRYAVPCMTSLVVAALYNMVDQVFIANAPDLGSVGNAATTVVFPLTVAALAIAVMLGDGCCAFVSLMLGAGKQEEAHRAVGETVTVSVLAGLVLMAAYLLFPDTLLTWFGGRVNAGTFEKAQEYFFWIALGVPLYVFGQAMNPVIRSDGSPTFAMVATLAGAAANLVLDPLLIFVCHFGMAGAAIATVAGQALTAGLSIWYLTRMKQIHLQKDSFRPRAHLLGKCAKLGMTSFLAQISLVAAMAATNTMLRICSAQDAVFSQEEFSAIPMAVFGIVMKVFQIVISCAIGLAAGCIPVAGYNMGAGRYDRVKGLLTRLLAAEAVVGLIALLVVELLPDQVMLLFGAQNESIHYTLFARRCFRVYLSMIVLACINKGTFIFLQSLGKAAASTLLSMAREIVFGVGLVLLLPQFFQLDGVIYSMPAADVLTAILSAVVLVRTYRSLETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4P2</accession>
    <name>R7I4P2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46829">
        <property type="protein sequence ID" value="CDE46829"/>
        <property type="gene ID" value="BN770_01039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435385" evidence="1">
        <location>
            <begin position="26"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="226" mass="24864" checksum="83A201528A8AF41E" modified="2013-07-24" version="1">MMKFMKRSLSLLISAMLLLGCFALAEEAPLLPIAIVSYDLTDEATMAALSALIEPKENALTRWERVVLSDGREAWVICQFDQTTMSNAWSRVIDAETQEVLQEDTTDTGFFATAQARWESAKGIYALWSIQDKMLFDRLYAMAPCYGEPVEGDLTQEEALAAALNVTGLTAADYDAVGYGYIMGSSEQNGTWQVFFVKGNEVVSTVNLDARDATILLVEPDEEGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Q3</accession>
    <name>R7I4Q3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46844">
        <property type="protein sequence ID" value="CDE46844"/>
        <property type="gene ID" value="BN770_01051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="240" mass="27160" checksum="A4B2AD9EA12EEFFF" modified="2013-07-24" version="1">MLDIQHLTRRYQNKLAVSDLSLTFETGKTYALLGPNGSGKTTLMKMIAGLTKQTSGEITLDGIPVGPETKKHIAYMPTESYFYSYMSIADAGKYYADFFEDFDERRYEEALQRMELNPKDKIRTLSSGMNAKVRLALTLSRDAQVMMFDEPLNGVDILTRKQVVDEIIRNRENGRTMIISTHLVDELNAYIDVAIFMKNGVLERIGDRAALEEKHGSLTNLYLSIYGGKEEEKHVEAAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I501</accession>
    <name>R7I501_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46710">
        <property type="protein sequence ID" value="CDE46710"/>
        <property type="gene ID" value="BN770_01009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="271" mass="31308" checksum="D67DDA41E1BC8F24" modified="2013-07-24" version="1">MKELHRARVVAIGSEEDMAAVCRTLLANCDWLEIPDDRPPYSLEELRQQVKKHAEELGGEESGFYYGMVARYTYGDADNRTCRFDIARQPSGLWTACFHYDGETPFQSEDWLYLHEHAGRVPMLAIHACADFAADKGMTVFTGGQTLDEWSQMAEIWFWLMEQYEIGNPPEEAVQHLKKLEGIMRQSDFDMTIPELLRGCIDHLNDVMAHTNQPDALRRLMDECAERKDYQGLFVVQCQVAETVLWDCTHVDLWLANLESILREWQKENPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5B9</accession>
    <name>R7I5B9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46686">
        <property type="protein sequence ID" value="CDE46686"/>
        <property type="gene ID" value="BN770_00993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="318" mass="36618" checksum="AF27E01DCE97CFC2" modified="2013-07-24" version="1">MQHYLFVHFREKTSPDGEQVHFAISRDGFHWQALNGGHPVLWAYYGDRGVRDMTIVRDHTSGKFHIFATDLSLSYGMRNQYQHSWRNIGLNGSRDLAHWVSDDLVHWSEEEMVRFGTDDMGCVWAPDVIFDSEHGEYLVHWSSKHRCNNFGNMAIYGSRTKDFVHYSEPELIYRKPDSSIIDSAMYEEKGKFYLFVKSSPNPDNLLLLVSDHVNGKFERVEGFDDSMGAQTKGMYEAPTAVKIADGRWCLFADFYGAGCAGQGYVPFVSDDLTKGVFTRADEAFHFPYGFKHGTILPITEEEYERMLARDWTDVPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Q6</accession>
    <name>R7I5Q6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46588">
        <property type="protein sequence ID" value="CDE46588"/>
        <property type="gene ID" value="BN770_00955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="302" mass="33888" checksum="29D1EE30D0C74193" modified="2013-07-24" version="1">MLFTNTDCLCFAKDPVVVRYRSRYWLYYSLRHEDGRFGIGIAESADMEHWTPCGEIEQDALCETNGIAAPGAIVLNDKIHLFYQTYGNWEKDAICHAWSQDGIHFTKNPENPVFHPAATWCCGRAIDADVCVFGGKIHLYFATRDHAMRIQKIGGAWAKIDSDFGRNAWHPLAEQSLLMPELAWEGDCVEAPATVVEDGRIYLFYGGSYNCTPQQIGCAVSEDGIFFRRVSNEPLIPCGAPGTWNSSESGHPYAFRDDDGRVFLFYQGSPDGGKTWYISRKEVQLGSSVRILTSEVDARESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5S4</accession>
    <name>R7I5S4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46826">
        <property type="protein sequence ID" value="CDE46826"/>
        <property type="gene ID" value="BN770_01038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="117" mass="13434" checksum="D8179A34C1815653" modified="2013-07-24" version="1">METFLPLLIILFLVILPLFARRKRAAAVRQFLNRKKQNKENNEMKELAKRLIGEDCIIYTITSESGSIQGVLKEVEDGGLVIEKTTGETEIVNLDFVTRIREYPRKKNGKKKSIVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I607</accession>
    <name>R7I607_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="8" type="ORF">BN770_01075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46926">
        <property type="protein sequence ID" value="CDE46926"/>
        <property type="gene ID" value="BN770_01075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="59" mass="6375" checksum="92B6A79E651D0B53" modified="2013-07-24" version="1">MRLGTTEIILIVVLALVLFGGGKLAGVGKALGKSIKDFKNEVKDDKAEEKSKEDKKDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I643</accession>
    <name>R7I643_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GGDEF domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46961">
        <property type="protein sequence ID" value="CDE46961"/>
        <property type="gene ID" value="BN770_01087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="286" mass="32618" checksum="1B11575FDC154D59" modified="2013-07-24" version="1">MKNETQSALVARDAAIILLLIWAFMQALLMIWAPADTQTMYLLLLFLMDIAVLCGFMDRVNTGTALAATITCGWVAYKLYSFYAVGETVYLTDYFVTVLPLLGSGAAALFSRSMRHVNAENKLLRRQVDEQVLVDDVTELYNLRAMYRDAQMMTGYCVRNHLPISLMIIQMRYESELRGMLSHSRYIQLRKRLAELVMDSVRVEDKVYCIDEHGTMAILLTSNEANSAYVRSRIIAAVTKEDAFDGILERGTHMDLRFACKEYDEHFGKDMMAFKKAVESELAYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6A7</accession>
    <name>R7I6A7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion-translocating oxidoreductase complex subunit D</fullName>
            <ecNumber evidence="10">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Rnf electron transport complex subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnfD</name>
        <name evidence="11" type="ORF">BN770_01120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NqrB/RnfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47026">
        <property type="protein sequence ID" value="CDE47026"/>
        <property type="gene ID" value="BN770_01120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00462">
        <property type="entry name" value="RsxD_RnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578:SF0">
        <property type="entry name" value="PTHR30578:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01946">
        <property type="entry name" value="rnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="10">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="33408" checksum="0D37786A37E9930B" modified="2013-07-24" version="1">MQNNLVMTSSPHLRDHSSTQRIMQEVCLALLPAGIAGVIIFGWSALMLICVSVATCVLSEFVWEKLTKQTVTIGDWSAVVTGLLLAYNLPANAPWWLAVVGGVIAIVLVKQMFGGIGSNFMNPALTARAILFVSWSALMSSYPQSNFVVDATTSATPLGLLSKGVSGVNFMDLLLGNCGGVLGETCKLAILVGGIYLCVRKIADWRIPVSFIATVFVCYLIKDGAEMAIYQVFAGGLMLGAFFMATDYATSPVTVPGRVIMGIGCGLLLFIIRAYANYPEGCSFAILFMNVCTPLIDRFTAPHPFGEVKKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6E8</accession>
    <name>R7I6E8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage/plasmid primase P4 family C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000047">
        <property type="protein sequence ID" value="CDE47439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47439">
        <property type="protein sequence ID" value="CDE47439"/>
        <property type="gene ID" value="BN770_01249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="286" mass="32458" checksum="6FC435D94A37ECF1" modified="2013-07-24" version="1">MMIIKGNGGEGKSQIGTVLKKLFGINAKDGSIGKISESQFARADLEHIHLLIDDDMRMEALKQTNYVKSLVTAKGKMDLEKKGQQSYQGHMFARLLAFSNGDLQSLYDHSDGFYRRQLILTTKVKSPNRVDDPDLADKLYAEMEGILLWAFEGSQRLVANRFRFSESERSRQNRELLKQDGNNLLMFLESEDYIQFDSVCAATSKELMAAYAIWCDDNGFAPLKSRTVSDFLISNASKYHIEHTNNIHSVDGRQVWGFKGIRLMIDAAVRSQSGFQRVYAMDNPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6H4</accession>
    <name>R7I6H4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0237 protein BN770_01147</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0237 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47091">
        <property type="protein sequence ID" value="CDE47091"/>
        <property type="gene ID" value="BN770_01147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04872">
        <property type="entry name" value="ACT_1ZPV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01054">
        <property type="entry name" value="UPF0237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022986">
        <property type="entry name" value="UPF0237_ACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="90" mass="10096" checksum="8A1FA0AB633E22CA" modified="2013-07-24" version="1">MTKALISVTGQDTTGIIARVATKLSELNINILDITQTILSGCFTMMMVVDLDGAQMEFAAVDEAFQPIREEMHLNIHLQRMDIFDAMHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6J4</accession>
    <name>R7I6J4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ALP_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000003">
        <property type="protein sequence ID" value="CDE46162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46162">
        <property type="protein sequence ID" value="CDE46162"/>
        <property type="gene ID" value="BN770_00758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10227">
        <property type="entry name" value="ParM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040607">
        <property type="entry name" value="ALP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042051">
        <property type="entry name" value="ParM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17989">
        <property type="entry name" value="ALP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALP_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="308" mass="34586" checksum="21907923A3A8005D" modified="2013-07-24" version="1">MRVFGKINIIGLDNGYGNIKTANGIFPASVTCCEAEPAHAQDVLVYDGKYYVIGAGHREFTLDKVGNQDHYLLTLAGIGQELWCNQLTTAAVHLAVGLPLTWVGDQRERFRAYLSQNRHVDFNWRGIDYHVDLVGVDVYAQGYSAVIPELRKFTGANMLCDIGNGTMIVMAINDRKPVLEQCFTEKYGTYQCVLKAREALTRLCGRTVPDVTIEQVMREGTADVAPEYVQVIREAAADYAAEIMRKLREHEYDPKTMRLWIVGGGGCLIRNFGQYDPNRVTIIADIHASAKGYEYLAERRLQREARAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Q3</accession>
    <name>R7I6Q3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000037">
        <property type="protein sequence ID" value="CDE47161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47161">
        <property type="protein sequence ID" value="CDE47161"/>
        <property type="gene ID" value="BN770_01157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435475" evidence="2">
        <location>
            <begin position="42"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="29467" checksum="7CC7C558000BE596" modified="2013-07-24" version="1">MRPNRADSALSQYFCSLLTAVLLLVSLLCGLIFFATTRTFAASVLSSSEKESQHKTEWNATQIQADFALSDAALAPLSGACAAYQAELAVYWHDFFRTDAEELPAAPAPLDEREMVALVMADEGFQARVDADFRRATARDEVVYPLSQSVQRYSFPIRQSLMELLGGLAAQKCSLPRLLHAVEISGAVCLLAAILLLLCCRRVRIGATLTATGLAALLLLLPALLLNLPGLLHPLSSIAQAQVTRALRLLGGAQAVFAAVTLLPGILLLRRAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6T7</accession>
    <name>R7I6T7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47350">
        <property type="protein sequence ID" value="CDE47350"/>
        <property type="gene ID" value="BN770_01220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="196" mass="20257" checksum="B5B49A659014A308" modified="2013-07-24" version="1">MTVGMLLATILLVLTFSGVLSGAWERLGIRQRTAGAWLLAMLAALLMPDVRLGAARVNPAGLAVTAAASVRLMMTIRPRRELVRVLLGSVIAGAMGLLVLILSDGQADALWACAMLIGAAACFLGVSRRGMLLCSLMGMLVAQGAAGVSGVLRADVQPWTDAVLLCASVSTALAEIVRRTAIFLLTPPGVKGGHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6T9</accession>
    <name>R7I6T9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47584">
        <property type="protein sequence ID" value="CDE47584"/>
        <property type="gene ID" value="BN770_01297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="34"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="288" mass="31762" checksum="5AAAE7FB60214599" modified="2013-07-24" version="1">MTEPLKRFKPNTKMVPVPSRSIIPERDVNHSPVLEASHLGIEFGGLKAVDDVNLAIGRTEICGLIGPNGAGKTTVFNLLTKVYQPTTGTVLINGKDTAGMNTVQASKLGIARTFQNIRLFDNMTVEENVRIGLHNQIKYGMFSGIFRLPQYWQGEKKQHEKALDLLSIFGMENMGDVKAGSLPYGAQRRLEIVRALATNPSLLLLDEPAAGMNPHETAELMENIIKIRDQFQIAILLIEHDMNLVMGICEGICVLNYGRIIAKGTAEEIQNNPVVIEAYLGKQKEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6X0</accession>
    <name>R7I6X0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_01235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47390">
        <property type="protein sequence ID" value="CDE47390"/>
        <property type="gene ID" value="BN770_01235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="11">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE47390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="640" mass="67816" checksum="F53B690B34CA3989" modified="2013-07-24" version="1">MKTIALVGSPNCGKTTLFNAVTGLHQHVGNWAGVTVERKEGTQNGVKWVDLPGVYALSPYSAEERVTIDYLSGGDYDEILQIVDATALARGLYLTHQLTQLSRPMTIALNMMDECRKRGITIDTEELSARLGIRVLPMSARDGTGVPELLRALKDGAKTPKSPPSAPYTAIIQRMKSALPAGNLPSEFRAWKALEGDEMGAAEAARAGQAQLRAQSGISAAAALSALRYAWADDLCAAVRQGNPDNPTRADVIDALVLHPVLALPILAGLLALMLSLAFGRFGSGLSDGLTNIILMIQSALDGVLGHWQVAEALRRLIVEGLMTGVGSVVSFLPMLLILFACLSMLEDSGYMARAAFLMDRPMRALGLSGRSFIPLLLGFGCSVPAALSARSMRGERDRRFTLLMIPFVSCSAKMPVFAALSTLLPGGAWMIFALCALGISLAALIAQILRKTLFPGESAAFVMELPPYRLPLMSSVLRKVLRRTGEFLSRACSVILLSSVVVWLIGRFTWTGAWAASTQESILGSIAGAIAPIFAPLGFGSVTVTAALLTGLLAKESIISTLAVLAGQGSIRAALSASLPTPAAALALMTFVLLYPPCAAASASIIKGLKSRKLAVLMVTGQCLLAWICAWIAYRLPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Z0</accession>
    <name>R7I6Z0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TM2 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000055">
        <property type="protein sequence ID" value="CDE47629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47629">
        <property type="protein sequence ID" value="CDE47629"/>
        <property type="gene ID" value="BN770_01317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="88" mass="9654" checksum="FBC8E79463FA424A" modified="2013-07-24" version="1">MLKLLTAGGLGIWALIDFIRIGVDSLRPADGSPWVEETRDENIRSIAANMQTIAEKLEKLQAQNGPAEAEKPEADGENQETHKVSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7I7</accession>
    <name>R7I7I7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46487">
        <property type="protein sequence ID" value="CDE46487"/>
        <property type="gene ID" value="BN770_00897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="635" mass="69923" checksum="57656C660B174AA0" modified="2013-07-24" version="1">MRYFGFDLGDGESCVALYSDQHIAPVILPVHGRNSFITALARYDGHPVVGALASDNPQAEDLRVCFKRNFRTNSDFVNQTVAAFAKGVLTALQDHSVVRHIMETEDVSFIVGCPADWADSDRTRYASLLMAAGLPNVRIVPESRAAFLSASTAEEDETLRRALMDCALVIDLGSSTMDLAYVCDGREYAVSTMGVQLGGGMLDELLLEQAVDALCAEEAELVREILREKSAWKSRMMLSARRLKEQFFTLGTGEELTRRETIFCEGRHVLNLTISAAIVEELCERPSPLLEGESFRSRMMNCLLMAQQMTAQRPPKVVLLTGGASRMTFFQQLCRETFPDSVLHVSATPEFDIARGLAYAGHVDEMVRRLKADAAAYVESDAVEQKVQSAMPALTEQLSDAMARQLTDSVLVPEYRKWRQGETATLGDMEDACQKQAESLLMSPEWSAALSEVVSPWLDNILMDVQRDLNRLCEQYGVDVQRLQIRQAMVTTSTLPMRDNLPMPEMPLMEVLLDIIVAMMAANLCGGGGIALIASGPVGLVIGAAIGLIAMFVSRPALDKLTRPLMRQMNIPKLLRKTANEQRLLSDSNQKKMAQTIRDALAEDEALQVGLCTQIGQCIDGAILRLTEEKGMAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7I8</accession>
    <name>R7I7I8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-N-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47461">
        <property type="protein sequence ID" value="CDE47461"/>
        <property type="gene ID" value="BN770_01262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="291"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="499" mass="56282" checksum="406AE72E88ECB6C9" modified="2013-07-24" version="1">MKQSKLILDKDYIISPIDRRLYGSFIEHLGRAVYTGIYEPAHPLADEQGFRRDVLDLVRKLNVPVVRYPGGNFVSGFRWEDSIGPKEQRPRRLDLAWKTTEPNTFGLHEFVDWAKKANTEVMYAINLGTRDILDAQYVVEYCNHPSGTAWSDLRIKNGAKDPFNIKLWCLGNEMDGPWQTGAKTAYEYGRKANEAAKVMKWVDPTIETVACGSSGTGMPTFGTWEHEVLMQAYDNVDYVSLHRYYGNPHNDTQDFLASTMDLDEFIKTVAAICDGVKGTKHSKKTVNLSLDEWNVWYHSKNQDHDLYKNKPWGTALHLLEDVYNFEDALLVGLMLITMLRNADRVKIGCLAQLVNVIAPIMTRENGGAWAQTIFYPMMDASMYGRGTSLLPKIVAGKHDTKHYNDVPDMDAAAVMDDAGNVTIFAVNRDLTEPMVLDLDLRSFGDLRPAMHSVLHHDDMKAENTESAPDVVKPVILPCPKPGEPLVLPAASWNVIRFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7J4</accession>
    <name>R7I7J4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumarate reductase/succinate dehydrogenase flavoprotein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47819">
        <property type="protein sequence ID" value="CDE47819"/>
        <property type="gene ID" value="BN770_01380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448049" evidence="3">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="435" mass="46409" checksum="A7878572BC8B6ACF" modified="2013-07-24" version="1">MVVDKLSLFGGSTSVSGAVVAAENTYYTQSIGLEPNSEVWLEEWKASSDSDIGVLGKDPGYPTYERVSNYFTQVGETINWLEDEGVAHWVTYPFFPNGRYQVPDYVIDSETGAADPEGGYMLIDHMVDWLKNHDADLRLSTTGTKLLTNDAGDVIGATVQDASGSYDVYASRGVVLATGGFAASEPMMREYLPQFADWIDLTTAGAGDTGDGMQMALDVGGVFYNDPYVITLGSTSRNGSIAGFCMSVNLWGRMVVNSKAQRFFNEGYMPYQATVALSRTEDGIAWALGDSKFAGAALLDAAVDGTEVVKADTIEELAALMGVDADTLVKSVETYNTACATGNDAEFGKDASNLTAIDAAPYYAVRIYVCTGGTIAGVKTNLDFQVLREDGSVINGLYAGGETSNREMYAYAYSSGSGVGYALASGRQIGMNLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7T8</accession>
    <name>R7I7T8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall-associated hydrolases (Invasion-associated proteins)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46582">
        <property type="protein sequence ID" value="CDE46582"/>
        <property type="gene ID" value="BN770_00949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447620" evidence="1">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="389" mass="43877" checksum="7584D346BCDE762C" modified="2013-07-24" version="1">MKKWCALLMTLLLILMTAGAEEFSGGKDFWDDAYRCTVENGYLTFQSDDGTTYQPIAVREGFAKAAKALAAQGDTFVAVPMGLTQALLPYVADELTGGAELVEIYCTTALIGMHLRDAAKGDVLRVAWWTGNGYQMIDKVVGEDFSLDTVHVSAGEVSMEVEGQEYALKLRNGKLVLWYTAGRKIVYIQPHAIGNMEEVIAMRNDSYVYGAHPFYNVEAVDFAAFPETYAEMLAQVDSTNWAVVNNPNPTDRLHLRTEPDRKSVSLGKFYNRTPVYVDEIRGEWAHVTIGRDLSGWMMTKYLAFGEEMDKVECAFPQLSLIEKYQENVADELAYDYYVFDAPNMSATKTLWNWGEECYLIGVIDNFYMIMDTDENVRYIPQDWLWAGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7V8</accession>
    <name>R7I7V8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47586">
        <property type="protein sequence ID" value="CDE47586"/>
        <property type="gene ID" value="BN770_01299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="294" mass="30999" checksum="2168ACD23A57310F" modified="2013-07-24" version="1">MLQFFSYLINGISLGSVYAIIALGYSMVYGIAKMLNFAHGDVIMIGAYIAFCATQYWGMSPLLGVLIAMIVCTMLGMVIERLAYKPLRQATSLAVLITAIGVSYLLQNLALLVFGPNPMSFPSFVSIPSISLFDGQLILTGETIVTVLANIIIMLVLTFFTSHTKMGKAMRAVSEDRSAAELMGIKVNATISLTFAIGSALAAIAGVLLCSTYHTLMPTTGSMPGIKAFTAAVFGGIGSIPGALLGGLLLGIIEILGKAYVSMELGDALVFAVLIIVLLVKPTGLLGKPMREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Y7</accession>
    <name>R7I7Y7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47979">
        <property type="protein sequence ID" value="CDE47979"/>
        <property type="gene ID" value="BN770_01469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448064" evidence="1">
        <location>
            <begin position="25"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="516" mass="58126" checksum="CC3757D6702B15F5" modified="2013-07-24" version="1">MRKLLAILQIFVLMAAMALPTAFAAEAPIMLAGLEAASSSSSTEAQHDWDTNLFFQTMQEKTGIAFSFTEYVSREAWTEAKTEMLAGEVAMPDMFFKAELTPQETLAFYEAGKLIDLRPYLAEYAPHVWALLEANPEWMEAVSLPDGAIVALPSINELTPNNTMWINKTWLDRLKMGVPTTAEELTEVLRQFRDRDMNQNGSRNDEIPLSFVSMWDLRFLAHAFGINADDYYLTEQNGKISEVLTTEENRAFLTWLHELYTEGLLDSQGFMAMRLVEAATSSSSSSSSEAAKYGVFFGATPQDVVGVNLASEYIALDPLVYNGQQVYRDFTGDLYRGTFAISSTCAEPEKLLQWVDYLYTDEGFLAAQVGREGEDYDWNDDGTWAYARTAEEVVAMQGTNTIWTTSMPSYASAEIQMKMDDDATHALAAELARVRQWEKRAMPLLYLTQEQMNRVTELQSGISTYAETRMAWFVAGDVELNDETWADFCAQVKALGIDEMVSIWQNAYDNAWHLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I826</accession>
    <name>R7I826_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000047">
        <property type="protein sequence ID" value="CDE47438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47438">
        <property type="protein sequence ID" value="CDE47438"/>
        <property type="gene ID" value="BN770_01248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9997" checksum="5BAA4949A7E62F9B" modified="2013-07-24" version="1">MIKMDLNLFGKIEENAPNNPHFLREHSQMTLTVPQLMKELNISKNVAYDLTREPNFPCFRLGRKILINRELLQEWLNRRCAPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8A9</accession>
    <name>R7I8A9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">BN770_01539</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48119">
        <property type="protein sequence ID" value="CDE48119"/>
        <property type="gene ID" value="BN770_01539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="167"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE48119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="350" mass="39437" checksum="B33843F9C0F555A4" modified="2013-07-24" version="1">MNEKIEALKSSFDSELKKIANMVDLEALRVNYLGRKGKVTDALKGMGSLNDEQKKTVGRETNELKTAITVALAEKLEALKAQELQREINALPEFDISMPPDMTRGSYHPITLVQRQCEQVFKSMGFTVEDYAEVVTDYECFESLNIPKFHPARDMQDTYYLDNGQLLKTQTSAAQNAIYRRYRDALVNDGVPIKAIFPGRCFRNEATDACHENTFFQMEGIMVDKDISIANLIYFMKTMLSEVFRKDIKVRLRPGFFPFVEPGFELDISCLICGGTGCPSCKHSGWLELCPCGMIHPEVLKAGGIDPEQYTGFAFGLGMTRLAMMKYGVKDIRDLNSGSLTRLAQFTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8I0</accession>
    <name>R7I8I0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47598">
        <property type="protein sequence ID" value="CDE47598"/>
        <property type="gene ID" value="BN770_01307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="65"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="284" mass="30246" checksum="66691222DE132D16" modified="2013-07-24" version="1">MKVKEQVMRWVFAATAAFSIAAVALICVFLFLNGLPFFTKYDLGAFLSGTTWKPANNIFGILPMIVGSLYVTGGALLFGAPVGILAGIYLARFCPVRLRKIIEPMIGLMAGVPSIVYGFFGLTTLVPLIREMFGGRGRGQCILTASLLLGIMILPTIIQLTSAAVKAVPNSYYEGSLALGATDERSVFRATVPAAKSGILASVVLAIGRAIGEAMAVKMVIGNQPRLTSDLLSGIRTLTSGIVIEMGYAEGLHREALIAAGIVLFVFILLINASFSVLKRREQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8W3</accession>
    <name>R7I8W3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000093">
        <property type="protein sequence ID" value="CDE48294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48294">
        <property type="protein sequence ID" value="CDE48294"/>
        <property type="gene ID" value="BN770_01625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="56" mass="6438" checksum="6C4AAD0B5E3F18AC" modified="2013-07-24" version="1">MSKYNALWDYVRSQSAPLLTLSFDEIQQIAGIPIDHSFLQYKKELTAYGCKSRKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8X0</accession>
    <name>R7I8X0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pyruvate formate lyase activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47946">
        <property type="protein sequence ID" value="CDE47946"/>
        <property type="gene ID" value="BN770_01446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="269" mass="30428" checksum="E2AC9E2FEEA15941" modified="2013-07-24" version="1">MSNPNPDMKGRIHSFESFALVDGPGVRCAVFLYGCALRCKFCHNPDTWCPSSISQTKEMTARELFDKAIRYKPYWKNNGGITVSGGEPLVQLGGIPVSGGNPLVQLDFVTEFFRLMKKEGVHTCVDTAGQPFRRDPEWLDRFNELMSLTDLFMLDLKQFDSKLHVDLTGKDNANILDMARYLSDNGKEMWIRHVLVPGVTDDENDLRKMSDFIASLKTVSRVEILPYHTLGVSKWQKLGIPYPLEGVPTPTDEQVKRAEDILNVTAYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9C3</accession>
    <name>R7I9C3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47873">
        <property type="protein sequence ID" value="CDE47873"/>
        <property type="gene ID" value="BN770_01408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004642">
        <property type="entry name" value="Ser_deHydtase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00718">
        <property type="entry name" value="sda_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="17"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="287" mass="29513" checksum="3052AC9A96C110B6" modified="2013-07-24" version="1">MDYTLHEWVRMASHHGSIARCAIEKQAEESGLDALAVREKMRHHLRVMQEAAQQGLDERLRSVTGLTGGQAALMMKRLQAGKCLAGNLLGKAEVYALATAECNGCMGKIVAAPTAGACGILPGAVLAMMEEKGATEEQAVDALFVAAAVGQAIATQASISGAEGGCQAECGSAAAMAAAALVYLEGGNPQQCADAAAFALMNLLGLVCDPVGGLVEVPCVYRNVGASGIAFTAADMALSGIRCPIEPDEVILAMKEVGDALPTSLRETGEGGCAACESICKRLHHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9D4</accession>
    <name>R7I9D4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="7" type="ORF">BN770_00115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48106">
        <property type="protein sequence ID" value="CDE48106"/>
        <property type="gene ID" value="BN770_00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="105"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="349" mass="38327" checksum="EE35D188CF7AC413" modified="2013-07-24" version="1">MMMDERKFRILQAIIDDYILTAVPVGSRTISKKYDMGLSSATIRNEMSDLEELGYLDQPHVSAGRIPSAKAYRLYVDQLLKTGRIPSDSDAAVKGHFLGRMHQMEDVIDHAAQVLSSLTSYTAVVLPPTGKMPKIRTIQLVPVSDTSALVVIVTDMGIVRDQVVQVASDLDSDALYAISKTLTERLQGLTLHEAVAQMPQLMQGMHENERLLQGLGKALGQQDEMTHPHVAVGGTSNMLAYPEYSDMEKARSFLSLMETRDRLADIISQKGEMAFTVRIGPETGVPEMADCSIVTATYSTGSGRQGTIGVIGPTRMRYSRVLSVMNTMGQQLSEMFGSQAPQKNKKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9H0</accession>
    <name>R7I9H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000037">
        <property type="protein sequence ID" value="CDE47162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47162">
        <property type="protein sequence ID" value="CDE47162"/>
        <property type="gene ID" value="BN770_01158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="26777" checksum="0DBD2070961EA29E" modified="2013-07-24" version="1">MMQKNTITVTSDKITQPLTFAFAADFHNGDADEALSLMRGCDAILIGGDLVNRHSRHGWRNAARFLDLAPRVAPTFYNLGNHERLLPDIAEYLPLVQKSDVTVLDDCFVDFRGITLGGVSSARKMPGMPPVRAQMDAKKPFLQAMAARDGVKLLLCHHPEYFAPLVQGLDIDLTLAGHAHGGQVRIGSQGIYSPGQGLFPKLTSGFYFDDKLFISRGMTNSACAPRLWCPCELVIVQLLPNRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9I2</accession>
    <name>R7I9I2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fhs</name>
        <name evidence="8" type="ORF">BN770_01563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000081">
        <property type="protein sequence ID" value="CDE48151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48151">
        <property type="protein sequence ID" value="CDE48151"/>
        <property type="gene ID" value="BN770_01563"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="586" mass="61705" checksum="27913FB7938BD72E" modified="2013-07-24" version="1">MPTDLEIAQAAQPKRIQEIAEKAGIPEGAISPYGQYIAKVDPMQLGVGSEMRAKLILVTAINPTPAGEGKTTVSVGLADGMTKIGKKAMLALREPSLGPVFGMKGGAAGGGRAQVLPMEQINLHFTGDLHAITAANNLLAAMVDNHIQQGNALGIDPRQVTWRRCLDVNDRQLRAIVSGLGGKPNGTPREDGLDITAPHAPPPGAPSPPPAASEVMAVFCLAKDLQDLKARLSRLQVARTYSGKPVTAGDLHAAGAMTALLRDALQPNLVQTIDGTPCLMHGGPFANIAHGCNSVIATTTAMRLADYVVTEAGFGADLGAEKFMDIKCRMSGIFPDAVVLVATVRALKSHGGCPKADLSHENVEALRKGLPNLLAHIDHIRNVWKRPVVVALNRVVSDTXRPVVAALNRFVSDTEAEMALLRQACADAGAPVELCDGWAKGGDGVKELAARVCGIVDSAPKSEPCYTYDITLPLKDKIEAIATRIYGAAKVEFAGSVLKQLQKLEDEGWRECPVCIAKTQYSFSDDAKLLGAPVGHTLHIRQVRLNAGAGFVVAFAGDIIAMPGLPKVPAAEAIDVDENGEIVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9K6</accession>
    <name>R7I9K6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LytTr DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48255">
        <property type="protein sequence ID" value="CDE48255"/>
        <property type="gene ID" value="BN770_01602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="249" mass="28720" checksum="B53CF553E3C7FA12" modified="2013-07-24" version="1">MRFSDISVISNRRHISLLTEDILYIQLSGRQSIIHFSDGRTYETYATIHELKSMLGSGFIRADRATLVSIKGIHDIGKEIELVNGETLYYSCRKKRELKEQLRAGRRQIAQSLSDSDAPATQEEYQRHYVSYDSAPFAFTDIEMVFNEERAAVDWIFRYGNEALAEIEKTPLQQLINHSFGSIFPNMDEKWLRVYERTALFGETLEIVYYSPEIDTKLKIISFPTFKGHCGCMLFKQTDIQTVGEYAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA03</accession>
    <name>R7IA03_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47342">
        <property type="protein sequence ID" value="CDE47342"/>
        <property type="gene ID" value="BN770_01216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="163" mass="18605" checksum="A44408507E523375" modified="2013-07-24" version="1">MTRLETQVLDLLREDCRLPLEKLAVMLGVSTEKVAETIDSLERRRVILHYAPTINWDLTDRERVEAMIQVSVTPQRDMGFDAVARRIYRFEEVKSVYLMSGGYDLLVLVEAKSLKELALFVSSKLSTLEMVTGTQTSFVLKRYKEEGVIFDGSQSDNRLVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA28</accession>
    <name>R7IA28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000081">
        <property type="protein sequence ID" value="CDE48153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48153">
        <property type="protein sequence ID" value="CDE48153"/>
        <property type="gene ID" value="BN770_01565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="183" mass="21164" checksum="9A400359709B6F72" modified="2013-07-24" version="1">MYMVDYEGTMPIFAYAYLTHDRRWTGPRAYRITIYQDDTLMFRTFNEREEVLDTDFFYLVPGTAAKLTVQIEHEGWWMGTVPLLIQADSKPHSTSMFGFSGHPMFRCEDLGNMIARDFGSHRGQLARGLYFMLENTAILLRQSNLILKLDSFEWDWAKAQIFTPAYAPPETTAPTVPQKENVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAC0</accession>
    <name>R7IAC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation transcriptional activator Spo0A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000108">
        <property type="protein sequence ID" value="CDE48436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48436">
        <property type="protein sequence ID" value="CDE48436"/>
        <property type="gene ID" value="BN770_01699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spo0A_C" evidence="2">
        <location>
            <begin position="85"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="197" mass="22028" checksum="D66FB6CE1D94B02F" modified="2013-07-24" version="1">MDDAKYPAFDTKPYRIVKSRSEASVPVNVAPTYYIVASDLQGFPLQQAIPLVQMSTSAQLAPRPPENQLPPLPVPRPGTPMRWYIASLLRCLGVPARLSGFNYLVETLLLLVNRPFETRLVTGEVYPVVAKQCNTTPIGVDQAIRTAVNQTWQEQNIPVYCALMGRSPAPHEPRPTSCEFLANVLMYVRIQMAECHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAD7</accession>
    <name>R7IAD7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2179 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000090">
        <property type="protein sequence ID" value="CDE48228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48228">
        <property type="protein sequence ID" value="CDE48228"/>
        <property type="gene ID" value="BN770_00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="253"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="326" mass="35653" checksum="6B02DB6DFF6F649A" modified="2013-07-24" version="1">MKKSPKSAKFFASHWSAFLQQFKDLHLRGDRFAMLTVAGLINAFGVSVFLYPVNLYDSGISGTAMLLAQITPDWCSLSLILLLLNVPLFLFGLKRQGVQFTIYAVYSVFIYSLGAWLIQGPLPLDVSISSPLAGTDLLLCALFGGLISGVGSGLAIRGGGAMDGMEVMAVIFARKLGMTVGTFVMSYNVVLYILAGLLRSSWILPLYSIIAYAVGLKVVDFVIEGIDRSKAALIVTRNPDAICRALGEAFGTGMTCIPAQGGFSHEEMTIVYFVVNRFQISRMKDIVHDLDDRAYITISEVADVFKLNQDKLSQKVDNQPLLPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAF1</accession>
    <name>R7IAF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48238">
        <property type="protein sequence ID" value="CDE48238"/>
        <property type="gene ID" value="BN770_01588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1818" mass="205539" checksum="270CA5B79042A4A3" modified="2013-07-24" version="1">MRKLFDQFEQLSTEAQALLEKGISQMRDGFAPAPSLCQKITSTLSSLRTAYDDIRRTLPDHVLTEELPEGELPVCEYEEVWKNSVVSRKKAVRAVLDEFIRVYSDEKKYMDAIEVYIQDAKDILACMDSAEMHAPSPDVSAFQLFLAGVKADLSSDEELYDQLLDSSAFSPRIVKGLHEKKYYIREVNVDKAPVSDTPCNESVAEAEPVSASEISEFPDTTAAAQEPQVESPASETPEDIEIETLTPEEFAARYASDAQESEESALSEMSEASDETAEDEEYIHPINPIKQTKLPSEQKLREMISRTGDVFHFLLNKLVFTGLMDEKCAFEALAQLPRPVTREQCIESFAFLERKGLLCTYEYAGRNILCFTELMGNCLQKSGLSSTLKRIYHLKSIGQIYFTGKQDMPLELFAHHMSMVDQYSKVIEMLDADEETAKKLETSAWNREKCYFLMNLTMDDGSLLPLHIVDSDDFGSSVPAENEGVFCCAGDLPGMDEVGDQLHYCLTANGLFHWSEGNWIAITHVEEENHDLPETVDSNVNAASESFSHPEVSQAEATDSETAAAPVEPIAPVKQLAIPAAEPVEGLWLDDLSEETGVEPEVTIDEFANLSSAEIAGRLLSAASNGNIPSDENMAVLIHQLLNEGVRSHDVRNCHDQLVEAVVFAKVLSSNDAFPLCRNIYLQLHAAIPFFREAGANTGVALSGIFADGTEFTPVTKLCAYIYGMLFPAHAHDHTFAALYNNAFTEYESQFPSLDVLKPLYHKAMEGVKLVPTAFSPANLAALGDSKIRQEHMNSIRSQAIELLKPPTVKVMIHGVPELIDLCFGSQTDLHTALQIVTDNDISMRELVKAELDKYCKDDDIDISTLERLLDSQWSVAAQKYSSRRMGIKYDARKHLLHAFEERLNLLRDWLDETNTESEPDIEKLRAIRSEVLYIIEDSLSEINIAPYSAAYGIMKASLELIRAKLQNQGSGVDFTTLLRSGMLVIDHGELILNDDLNAIEFAEPWRMMLQHIACTEYDLKIVYDRILEASPDSVLYDNFGQMEAIGRLIGADPKEYVLTSDGLRDAINSADLQARNFREKLEISYAYNRISENDRERLAMLANPEASDFQKFFYDHRAFGCWRGFLNALRAQIRETAQQSMHDVRAQLDQAKAMLRADEESPLIAEAERLISQEQNYAVAEDYIHRFRNGERDLPFETSNDAIEHFLRFISDDEFPRLYGFCERNKQDPMPRWAVQYMKKNTPEGWTTRHIEDARRFIEKWPVGKQSVNAQNIQEYFNLLGFHVECCAKSTRGNEVCCTLTVHKTEQNLADYRHPISIFGTQMKSQIEVVCLFGKRTATQLIDDACKLGITSTFIVLLDADLSTADRRAMAKYVFTQKNVGQASFLVIDRVLALYLAMQSSNERLPAMLQCTLPYTIYQPFTNGSGSTADEMFFGRVSELASIRDMAGASIVYGGRQLGKTALLERAMHLDHNPARREFAIKADFKGHRGEQDFLDILVSACNDVFEKNDFKLNRCATIRDFCSQIRRLLDNDRIAILRLLLDETDDFLDSISASSYNEILPLIELQRGSNRRFKFVLAGLHNVCRAKNATRNNGLFGQLGEPLCVKPLTAADAQRLLVRPLRYLGFRVSNESHVDTILTNTNYYPGIIQFFGYTLVQTLVTHYTQYYDAVRGNPPFDLHDDQLASIMNSRDLNRNIKDRLRWTLEMDDRYYMLARCITVLYHLYSNNYSVISSGFDVASICEVKDMYDIHCLESLSEREIVALLDEMEEMGILSRPTAEENRYLLRRRSFIDVIGTSLEILEHDIETYNEEAANNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAF5</accession>
    <name>R7IAF5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48243">
        <property type="protein sequence ID" value="CDE48243"/>
        <property type="gene ID" value="BN770_01593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436318" evidence="1">
        <location>
            <begin position="24"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="250" mass="27503" checksum="F5C6CEB567BF7F0E" modified="2013-07-24" version="1">MKKMMVLVLSILVLLAGFTTAMAVGTIDFSGYSLEELLEIRSDLADEIASRPGGEKIVLGAGQYKIGESLPAGVYSFKFVQNGDSDVSRTDYYVYESESMYKYDIDRLWLGDMPRVEGDFMGDGETRISLYPGEYLSLRYNGAEVARVGNVSERGNGYTAPAGTTIPKGNYTIGEEIPAGTYKIYFSGTTTSRVRVFQDSQEASNTFNKGKETILDWDNTEGIVTLSEGNILRIEYTPIIMTKGGGFSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAG4</accession>
    <name>R7IAG4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000050">
        <property type="protein sequence ID" value="CDE47512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47512">
        <property type="protein sequence ID" value="CDE47512"/>
        <property type="gene ID" value="BN770_01272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="4">
        <location>
            <begin position="131"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="373" mass="41684" checksum="B330B03ACEA34D95" modified="2013-07-24" version="1">MGERYTQEIEQSKQQVFAACGTTFNLNSTQQLGDVLFDKLQLPHGKKTARGYSTSAEVLEGLQDIAPEVITPLLRYRQLTKLNSTYVEGLLRLTDATGRVHSTFDQVATATGRISSSEPNLQNIPVRTEEGKEIRQAFLPREGWVLLDADYSQIELRLMAHFSGDHALVEAFRTGQDVHARTASEIFDVPLDEVDSTLRSRAKAVNFGLIYGISGFGLAKNTGVSRQEAQEFINRYFAKYPGVKRFMDSAAEDGQHNGYALTLMGRRRYLPELKSDKAVVREFGKRAAMNTPVQGTAADIIKLAMVRVDEALRREGLKSRLILQVHDELLLECPPEEVEKAGKLLKDAMEHVIELRVPLLAEVHQGTNWAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAT0</accession>
    <name>R7IAT0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="6" type="ORF">BN770_01316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47612">
        <property type="protein sequence ID" value="CDE47612"/>
        <property type="gene ID" value="BN770_01316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="5">
        <location>
            <begin position="523"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="862"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="241"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="426"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="683"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="753"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="862"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1187" mass="134556" checksum="6D5194BD20BD265A" modified="2013-07-24" version="1">MKLKKLELYGFKSFAQRTEIVFDEGITGIVGPNGSGKSNIGDAVRWVLGEQSAKTLRGASMSDVIFNGTQKRKPLSYCEVSLVFDNDDHALAMEAAEVMVTRRVYRNGESEYYLNRTACRLKDVVDLFRDTGIGKEGYSIIGQGRIDEILSRKSEDRRQVFEEAAGIVKFKARKEEADKKLQRTLENLERVDDILDELTKRLKPLEEQSRNARVYLELSTELKDLDLNLFLIRSDRARARLSELESELLTVQTILADTESNLTDKTTRRDETQNRIDQLEEAITKARTELMECAEHVHESQKKISALQSRRETRSENRQRIVREQEEAQERLAEIEKDHARIQADVEKQHSLIADAEQILRATQEAAEKAQAKEKEADAALEAQKAAVIDQMNRLSDVRNDKTRLNTMQAQMETRLTEIEESGGALQEQEAALREALTAVEKQLETENQHQQQCQEKLAQARQASDEADAAYANLRADVEKQSADMQAAASRHNVLTEMTRDMEGYNMAVRRAMTYAKQRGLKGVKGVLAQLMTVPQAYETAIDMALGAAQQNIVTDTEETAKELINYLRQNRLGRATFLPMSAIRGKTLYGNERNALKLPGCLGVASELVQCAPEYRGIVENLLGRTVIADNLDHGIPIMRAGNHAFRLVTLEGDVMHSGGSMTGGSAQSKVSNLLSRERELKELTAKLQTGRAELDKCRQELTQRQQTAQEKRQKVSDAVNALHQQEIAVAREQARRESVSADLNTHLQRMQETEQARVQLHQSLEDIRQQLETIEHQRTGAQGDQSAMEQKTIEMQNALVKARAEASAENDRLMVRTLQLSDLRHGLSDLERDEAHAQQDQAQILREQERREQLLHEMDELDAIDENDMKREEAESARRQKEQLRQESAAQAIEQRRSQAQSDLRDILSDMENLHEAYNRDSEKLHKTELAKARIEGDQKNLQNRIWDTYKLTYAGAEEFRRTPFDEKESDRRAAELQGQIRALGTVNVGAVEEYAETKARVDDLTAQQQDLKRAEMDLRELIERLLIQMRSTFVENFSKMQGYFAETFTRLFGGGHAELKLMDPDDPLNCGIEVNAQPPGKKLQLLSLLSGGERALTAIAILFAMLKLKPTPFCILDEIEAALDDANIGYYADYLKEYSKGTQFIVVTHRKGTMERCNSLFGVAMEEQGVSRMVSVSLQDYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAT6</accession>
    <name>R7IAT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000104">
        <property type="protein sequence ID" value="CDE48403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48403">
        <property type="protein sequence ID" value="CDE48403"/>
        <property type="gene ID" value="BN770_01685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="297" mass="31794" checksum="52657D9400CFA03F" modified="2013-07-24" version="1">MKTLCVDLGGSRVKLALMTADSHPQPDVFEVDSRAPLAQTLSLVAQHAAAWGQPDAVSIALPCVVCRGTVIACNGKYTDAVGFDWMRWSQKTFGAPVFLMNDAAAALLGEMRCGAAKDTDAAASLMIGTGIGSAAAQDRRILTGRHGTMGMLGGHMAIEMLHPRRCTCGATGCLEAWAGTWALDEIARQEDRFAESALANARKVDYRALLDGVAQGDAVSLRVFETVATALGMGAVNLIHAYDPEVLLLSGGPCHSEMLMQRIRRYVRENVWTPWGQVDIRVAENPEGSVLLGLIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAZ8</accession>
    <name>R7IAZ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48478">
        <property type="protein sequence ID" value="CDE48478"/>
        <property type="gene ID" value="BN770_01716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043751">
        <property type="entry name" value="DUF5696"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18952">
        <property type="entry name" value="DUF5696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="871" mass="96191" checksum="A28E791068B4AC7F" modified="2013-07-24" version="1">MSEQTKIKHSPAVEGKKHHKVRWIVLAVLLVIVAAVAAWYLIRFEFNRDYQAYIEAPKGAAAQSELAALTDENPNVAAPFQLFAENDNLKLYADLETANVAIYDKRSGETVYSNPVDADADKVANKTNKNYLKSQFLLDYYNAGLTSSTYDSYSMSVALGNFRAAAIEDGIAFIYDVGVDSIQYLTPSYLPTERYEGLYEQLSAQAKKAANIVYEKRDDGYWISATGASRTREMARVSKEFVALGMTKAEYLEMEALAGKEQAETLGFTVTLEWHLGEDNVEAKLPVSAIEERGGGKVYRIQLLPYMAAAGSDENGYMVVPNGSGSLIRFNNGKNSAAVYSQYVYDMDLIDGDYTQTQTIQSVRLPLWGVCRENTSVLATIENGASLAAISADVAGRNNSYNNAFAMFTLRGSELLSLFGAGETAEMPIVEDNYYGEDLVIRYTFLTAENKGYSGLANYCRARLIAENVLSPLEETGDIPFYYDVIGGVKETTHFMGIQYLHVRAMTTFDEAVEIAQTLNKAGIKHQVMNFQGWMNGGYYHDVANNVSVLRQLGGKDRLENLNSAISRLGGELYADVAFQKVTQISKHYMENQETSRYYGAGYIAQFGVTNPASLRRTSALGYSENIYNLLSPKFLPYYVSGFLNSTKDYSLNGYSLRDLGCELHADKRRTELINREQALMIVESQLQAIADSGKKVMVSGGNFYALNGVKHVIDAPMTATEYVIVDETIPLYEMILHGCVDYTGQALNTIVSDDWQAKLLKMVEYGASPRYTFTAQQASDMKYTALNRLYATTVANWTDTAAEQYAYLNAALASVSGAQMVKHTILSDTLRSVKYDNGVTIYINYGSQDAQADGGTVPAKAYLVTGGANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBQ4</accession>
    <name>R7IBQ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49020">
        <property type="protein sequence ID" value="CDE49020"/>
        <property type="gene ID" value="BN770_01896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="299" mass="32944" checksum="2EA8734FB01CB2BB" modified="2013-07-24" version="1">MSQAMMKVQPKTKDQQTGAHAVLTARRIVAYAVLILLCALCLFFFYVLIINATRPHADIQKGFSFLPGSWTSLCNNFTQVINNANIPIISGMRNSLIVSAMTAIFACYFSALTAFGIHAYRFKGRALALTFILLIMTMPTQVSALGFVQLMGKMNLKDSLLPLFLPSIASPAVFYFMYQYMQASLPLEVIEAARIDGSSEFGTFNRIVLPMIKPALAVQAIFTFVGAWNNYFTPALILNSANKKTLPILIAQLRSADFLKFDMGQVYMMIALSILPVIIVYLFLSKFIIAGVAVGGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBR2</accession>
    <name>R7IBR2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA nucleotidyltransferase/poly(A) polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48926">
        <property type="protein sequence ID" value="CDE48926"/>
        <property type="gene ID" value="BN770_01865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="7">
        <location>
            <begin position="294"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="446" mass="49420" checksum="AF7BE551F68B57E7" modified="2013-07-24" version="1">MLTIPAGADFILRRLMENGFDAYVVGGCVRDSLLGLFPHDWDICTSARPEQMQAVFADCRVIETGLKHGTLTVLHDRIPYEVTTFRVDGGYTDHRHPDSVSFVSNVVDDLARRDFTVNAMAWNPQTGLVDAFHGQEDLRAGIIRAVGDPQTRFTEDALRILRALRFASVYGFRIDDATSQAAHDLCHTLTDVAAERIRVELAKLLCGQGAADILRAYPDVLFVLLPQLRAMHGFDQHNPHHRYDVWEHTLRALPHIPPTETLRLAILLHDSGKPDCFTLDEAGIGHMHGHAERSAEIADEVLSSLRVDNATRERVTLLVRSHSLSVSPDHKLLRRRLNQLGEEALRELLLLQRADQLGKGTIPPEEIKAEYRTVVAALDALMATSPCFTLKSLAVSGRDLMAAGLPKGHIVGQALAYLLDEVMAERLPNARDALLDAAIRQFGGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBT1</accession>
    <name>R7IBT1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48946">
        <property type="protein sequence ID" value="CDE48946"/>
        <property type="gene ID" value="BN770_01878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="184" mass="21152" checksum="D6220781652CF46B" modified="2013-07-24" version="1">MPILRGKNVLLRPYRRSDLPGILSWTNDTEATRYLTEIFDQPYTEKNGEDFLNYALSGGSERMMFVMADPVTEEYWGQISLERISRRDGTAEVGVVLAKEEHRGKGIGREALSLLLRYAFDTLGLRRVELTVFAENSRARLCYLKAGFIEEGVARQKTWKNGKFHDVVSMAVLRDEWAKREEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBT6</accession>
    <name>R7IBT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49055">
        <property type="protein sequence ID" value="CDE49055"/>
        <property type="gene ID" value="BN770_01902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="466" mass="51270" checksum="8871825C581794EF" modified="2013-07-24" version="1">MKQETGRRIARWGYMAVAAGYLWWNLARMTEFSWTFTVMPYLGDLGIIAAIFSLILGWKKRSPLVWTMTAGLGWMLLMSAIRGENVLAAEWQYLKEGIIAFLVLAPLPGCLTENRFRQFLKGTIAVWTTAITCQAAIGLWAAISGHAVFSMKGTWYIGMNLGDHRLYLNAYVTTAAAKMGMTVLLTAILFTLSRTKRAKIACVMAILVQCGALALTDCRTAFVALGVAAGFCVWTLLGAKVHMPSKLNHRLMLPVLMASGIILCYGLLAGLLTLLAPSVAPGPLDNVNLLEFPAHLMTEASAEQEVILDSTPVHRSIDTTDTFNGRWGIWKGALRLLKAQPELLLTGTSAPLAAGMMNLYTDPGTKYFQHAHNLYLQTLVSWGIPGLLILLAVISIFFTQTARISKRNQPLWVLMLPLPVIYLLVCELVDCFTMLSTGSPMLYWLCLLMGAVDAQARRLKPQALPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBV9</accession>
    <name>R7IBV9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oligopeptide transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47997">
        <property type="protein sequence ID" value="CDE47997"/>
        <property type="gene ID" value="BN770_01479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34816" checksum="F2D331E1DC875009" modified="2013-07-24" version="1">MTKYVLKRIGMALLTLLIIVFLLFLLVRIMPGNPFPSERMNAQQIANKRAELGLDDPILTQFWNYLTKLLQGDFGKGTSLYNGAPIKTVLATCVSNSFRIGGLSVLLGTLVGLLLGICAALHRGRFLDHFCTVFSILGVCVPSYVFLIFLQYNFAYQIPLLPYFFDSTNFLRSSVIPVVSMSLFTMSTIARFTRNEMVEVIDSDYVRLAESKGLYGGRLVRRHVLRNALIPIVTVLAPLVVDLLTGALVVEKIYGINGIGKLMVDAIAGEGVDYNYVLALGILYSSLYIGIMLVVDILYGALDPRIRVSAKGGANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBX3</accession>
    <name>R7IBX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48012">
        <property type="protein sequence ID" value="CDE48012"/>
        <property type="gene ID" value="BN770_01491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="128" mass="15167" checksum="327D5707A1D46A23" modified="2013-07-24" version="1">MKMMMTNELPAEIMENGIHYTLVGDYYFPTCMLADRSPNGKWASLYERYLQEKHPHEYVRLIWADELAALLESVQKECEERVEVLVREMAEVEGVDEEMKENEQMEWVRRMEMICGRAEEIVRGELMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC61</accession>
    <name>R7IC61_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-xylanase</fullName>
            <ecNumber evidence="5">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48092">
        <property type="protein sequence ID" value="CDE48092"/>
        <property type="gene ID" value="BN770_01537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447800" description="Beta-xylanase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="326"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="660" mass="73006" checksum="166CA6F335AD284F" modified="2013-07-24" version="1">MKHWVAQALSLLMALCLFLPCFAAAEEAAQTAITIDFEDGNAAAFSQSGSCTVGVTESQAHSGKQSLRVSGRGSNNWDAVDLSAASLGIEAGAKVHLSACVYVESSEDGVMAIGKAGGDYAYYAQVNVKGKEWTEISCDFEADAGVNIRFLTASDNYLGKNYCIDDVTLTITAPEKMDYSDAPQIHYTSDFTSGTDGWYARSAGGATIETTADGLYITGRTATWNSPGRDFDLVPGRAYNLSVQVKQDEMDSCSFILSVAHTRDGEESYENIVTGTAKKGEWAMLSGSYIPGRYDKYVLYVEGAGKETSFTIRNFTCDEKIDSFDTTSLPALKTLYADKFDFGTAVVASEVRDSKRMAFYGSQFTIMTAGNEMKPDSLLDMAACRKLSRTDDTAVAVKFDNCIPFLDWCRDNGVKVHGHVLVWHSQTPEAFFHEGYATHKPLCSRETMLARMESYIQQVLTWTNENYPGLIVSWDVVNEAVADGSDQLRESNWTKTVGQDFVNRAFEYARKYAADGVKLYYNDYNTPLDPKLHGICVLLDSLIADGTIDGYGFQAHYSVGSPTIDRVDWAFQQIAKRDLLLRVSELDVGIDDTSEENLQKQAKYYGNLMKIFLRYADRIEAVQVWGTVDDLSWRADEYPLLFDKDAQPKPAFDTLVELAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICI5</accession>
    <name>R7ICI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter YbiR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49211">
        <property type="protein sequence ID" value="CDE49211"/>
        <property type="gene ID" value="BN770_01939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="16"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="367" mass="39163" checksum="BDFC7B68A29AB1B7" modified="2013-07-24" version="1">MVKRILQYFRRETVLSAALVCALLSFLLTPPSVIHLQGIDTTTLLMLFSLMTIVAGFRRMGALDAVSRKLTRCVTTLRGLSAVMVALCFALSMLVTNDVALLTLVPLTLLLFRAGGQKSTIWTVVLETVAANLGSMVTPIGNPQNLYLYTSGRLTALDFLTLLAPYAAVALALLLALCLLLPKERVAVDTSARVPLARKMLTLYGALSALALLAIAKVLPAWALAAAVFLGTLALDRGTIRQVDYTLLATFVCFFVFVASVKACEPVRAWLEAMMARSPMAVALLTSQVISNVPACLLLSPFTQDAKALALGVDLGGLGTLIASLASLISFRLYGAGEDAQKGRYFAVFTGVNVLFLAVMLFLAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICK9</accession>
    <name>R7ICK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter ATP-binding protein CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49330">
        <property type="protein sequence ID" value="CDE49330"/>
        <property type="gene ID" value="BN770_01977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="386" mass="43140" checksum="7CBE0588BD8082A0" modified="2013-07-24" version="1">MASVSLQHIYKVYAGGVTAVSDFNLDIKDKEFIVLVGPSGCGKSTTLRMVAGLEEISDGELYIGDKLVNDVAPKDRDIAMVFQNYALYPHMTVFDNMAFGLKLRKTPKDEIKRRVEEAARVLGIDHLLNRKPKALSGGQRQRVALGRAIVREPKVFLFDEPLSNLDAKLRVQMRTEITKLHQRLQTTFIYVTHDQTEAMTMASRIVVMKDGVVQQVDTPQNLYDFPANEFVAGFIGSPQMNFFDVRLKRENNEVVAYFGDNKIVVPQGKVSKFVDESYVGREVVMGIRPENIHDDEMFLANAADATIDVKVEVTEKMGSETYLYLTTTGKEGNIIARVNPRTTSTAGGEIKVAFDVNHLHFFDKETARTILVSDAVPAPTKTNLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICL3</accession>
    <name>R7ICL3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferases involved in cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000148">
        <property type="protein sequence ID" value="CDE49629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49629">
        <property type="protein sequence ID" value="CDE49629"/>
        <property type="gene ID" value="BN770_02060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="299" mass="34106" checksum="26A30CE258B54E09" modified="2013-07-24" version="1">MYLSNPMVSVIVPVYNAESTLRRCADSILEQSYPDLELILVDDGSKDASPLICDSYMQKDARVRVIHKPNSGASATRNLGIAEARGHYLQFVDSDDWLTPDATEKLVAAAEAHQADLVIADFYRVSGKLVASKHRVMPVGVMTRREYASKMMENPASFYYGVLWNKLYRRDLVVQHHLEMNPALRICEDFMFNLEYLRVARYIVAVPSPVYYYVRTKNSIVSQTYGMTTLKIRLAAFDEYKQFYMDVLDERAYQKARLKVYRFLVDVAMDGVVLPKPAPGTRSLKAADSPETLDDDWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICM0</accession>
    <name>R7ICM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase Family 2-like b-glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49053">
        <property type="protein sequence ID" value="CDE49053"/>
        <property type="gene ID" value="BN770_01901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35950" checksum="53B16818A583117C" modified="2013-07-24" version="1">MVDIIIPVYNALDTLELAVTSALMQGDVRIFLVDDGSTDGTARLCDELAHHPRIEVIHQQNHGVSAARNAGLQAAASEWLTFLDADDVLLPDAIGNLLALAGDSQAIQGLVTRSGASNVPECTVQTLSSRDMLDLALRNPTVHLHTHGWLLRREICNEKFNESLRLGEDGEWMMRALRGAKTVSLAQVNTYCYHLRADSAVHSASDVVREYLRTLTAAQPTLNYLDIPNAAAQYRLMHLLLMMTHGVVREGGFRDGLRQCRAIRRLCREAFRADLRRVRWLPRSKAQAVLLMLRCGLYPLARRAILIRRRQNQQACASGESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICT7</accession>
    <name>R7ICT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49435">
        <property type="protein sequence ID" value="CDE49435"/>
        <property type="gene ID" value="BN770_02015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014213">
        <property type="entry name" value="SpoVT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026579">
        <property type="entry name" value="Spore_V_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02851">
        <property type="entry name" value="spore_V_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="185" mass="20221" checksum="9879436EFEBB5585" modified="2013-07-24" version="1">MRATGIVRRIDELGRVVIPKEIRRTLRIREGDPLEIYTDRDGEVILKKYSPIGEMSSFAKDYTESLFRSLGHIAVIVDRDQVVAASGLPRKELGDKPISRALETAIASRQTVALNQQSGGRMVAVTTEEDQNPNYTAQVISPIIADGEAIGAVLLMSRDNGVKMGDTELKVAETAAGIVGRQMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDN3</accession>
    <name>R7IDN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48682">
        <property type="protein sequence ID" value="CDE48682"/>
        <property type="gene ID" value="BN770_01789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026002">
        <property type="entry name" value="ATC_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14196">
        <property type="entry name" value="ATC_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="204" mass="23433" checksum="9FB482FE114C302B" modified="2013-07-24" version="1">MGMWMLFHRSFTHQLTAVLGQSAESAKATEKAAKQEYRRIIARVPDFEPSDRFQMNLVNCAMLCAYVLHMPKRPTVQTLTDYYAKSMMTPAMRWFCRKSGKNKFSDKDIAGMKQAEKLRAADRNPYSWNMDYLPYADDSGYEARFYKCGICVLTKELGLYDLTPAMCRLDYTMAEAGEASDFVREYTLASGGPYCDCGYHKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDR7</accession>
    <name>R7IDR7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RelA/SpoT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49735">
        <property type="protein sequence ID" value="CDE49735"/>
        <property type="gene ID" value="BN770_02111"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="61"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="225" mass="26307" checksum="832C2076094A682B" modified="2013-07-24" version="1">MNTDSQHLQQVSEEFQRMVEEFFLVQSRYSAAIKEIQTKLEILDDEFQMRHRRNPIHHMQSRLKTIQSMLEKLKRKNYEVSINSAVKNLQDIAGIRVICSYVQDVYTIANLLVSQDDVHLVRMADYIREPKPNGYRSLHLIVEIPVFLSEGRILVPVEVQIRTIAMDFWASLEHSLRYKAQEYIPQHISDELQRVATDIASLDQRMQAIHDQVDELSDARSDNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDV1</accession>
    <name>R7IDV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic solute-binding family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE50009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50009">
        <property type="protein sequence ID" value="CDE50009"/>
        <property type="gene ID" value="BN770_02232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435766" evidence="1">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="322" mass="35457" checksum="5B4126FEB64218CC" modified="2013-07-24" version="1">MKTKKLLAALLTLLIFLSPTFAAAETVVTSFYPIYLFALNLTQGIDGITIRNLAAPNTGCLHDYQLSTGDMKVLNKADVFLINGAGMESYLTRVMDTFPKLPVVDASAGITLLTEDGMDEYVDDHDHDHDHEEEDADDHGHHHAGEANAHIWLDAQNAIQMVDNLADGLISAMPQYEAQIEQNRADYVSRLTALDAELKETLAAVPNKNIVTFHEAFPYFARAYGLTVAAVVNHEPGDALSPAQLAELVRTIRELNNPPLFTEPQYDDMAAQTISRETGAPIYTLDPVVTGPETDVPLTYYEDRMRENMQTLLVALTPAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDV8</accession>
    <name>R7IDV8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48732">
        <property type="protein sequence ID" value="CDE48732"/>
        <property type="gene ID" value="BN770_01794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="457" mass="50162" checksum="EA700BB146DC0A5A" modified="2013-07-24" version="1">MSEKQEQQNTERSRMLGTMEMRKLVPTVSVPIMVSMLVQALYNIVDGIFVGQYSPDALTAVNLAMPMQMLMIAVSTGMGTGINSLISRRLGEKRPHEARDAARHGILIEVVGWLLFVIVGLFFARAYIGMTNPKAEVLEMGTLYLRIVCTLSLGQFMSICFERMMQATGNTTLSMITQLSGAVTNIILDPILIFSCQMGIAGAAIATVIGQVVSCTVGFTLNQWKNRELRLTHEGFRFDWKTVQNILVVGIPSTIMQAISSVCTTLMNMILAGFGDIYVNVLGVYFKLQSFVFMPVFGLCNGMVPIVGYNFGAQKKKRVYECVRVCLVYALVIMAVGALLFLAVPNLLMMPFDSSADKALTAEGCVALRIICSHFLIAAAGITLSTVFQAVGRGTYSLIMSLCRQLIVLLPATWALSLIGPNAIWWAFPIAEIVSLTICLLLYRKCDRELIAPLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE60</accession>
    <name>R7IE60_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_02096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49711">
        <property type="protein sequence ID" value="CDE49711"/>
        <property type="gene ID" value="BN770_02096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="380" mass="42823" checksum="CE728B3E70EFB487" modified="2013-07-24" version="1">MEIYLHVPYCRQKCRYCDFASFPHAESTQRAYVDAVLTEAASQAAKLPHSIMETAYLGGGTPSILPPELLTRLLEGVAAHFPLAPGAEFTSEANPGTLTHAWLDAALNCGINRLSMGMQAAQPALLKMLGRIHDFTQVQQSVELARHAGFQHISLDLMFGLPGQTVSMWRETLEKALSLNPEHLSCYGLIPEEGTPLYRDLQTGQLTLPDEDDERRMYDLTLDLLAQSGFRQYEISNFARPGCECRHNIGYWQQEPYIGLGVSAASYLPAKNGMIRLTNPRTLPAYLRMVQSQDDSLREREFVSKTDGRFETLMLGLRMTRGVSETEFQERHGVSLDALYGEKLRKFEHEGLLQHKTDRWSLTRRGMDVQNAILVELMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEF6</accession>
    <name>R7IEF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49708">
        <property type="protein sequence ID" value="CDE49708"/>
        <property type="gene ID" value="BN770_02094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010697">
        <property type="entry name" value="YspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38440">
        <property type="entry name" value="PTHR38440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06908">
        <property type="entry name" value="YpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="214" mass="24340" checksum="5BAF92D9DF2B20CC" modified="2013-07-24" version="1">MLYRKSQVSDRWLRAPLQAPTALHQPLSYISRSHIADVFASQENGRKDISVCFTGHRAIPPQELPALTERLDRVLKALYQHGFRDFICGGALGFDTLAAQRILLMRTHHADVRLRLAIPCSTQSARWKASDCLIYEQLLYAADETVVLSSHYYEGCMYMRNRYMVDNSAFCVCYLNRQKGGTMYTALYAMQEGLPLLNLAIASDCERLIQKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEI4</accession>
    <name>R7IEI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-E processing peptidase SpoIIGA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50045">
        <property type="protein sequence ID" value="CDE50045"/>
        <property type="gene ID" value="BN770_02246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005081">
        <property type="entry name" value="SpoIIGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03419">
        <property type="entry name" value="Peptidase_U4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="252" mass="27287" checksum="72EE6EAF2BADA2DD" modified="2013-07-24" version="1">MRASGFLFLLEQGLCGICLMSALSAALGLPRVNRGRRLLFALLYAGFTLLSLSVPPLLQVVMVLPLTGLLAFVGRFPARRTLPFCLTMLMMQWGCAGLSALLPLPGAVQTALTCTLLLLLRRLTRLEHGKRRFVRVRIRCGDCESAVTALVDSGNLLCDPLSGDPVLILPRNTFRRLTHLPEGSTLLPGMRLLRARTASGITLMIVLRPDGIFLLSGWKETALRGLIGCALSDGGVHQPVMPESMVSAILCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEP2</accession>
    <name>R7IEP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50254">
        <property type="protein sequence ID" value="CDE50254"/>
        <property type="gene ID" value="BN770_02336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="117"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="225"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="444" mass="46476" checksum="420C6649EDEC2AF2" modified="2013-07-24" version="1">MKVNEFLNEVLAAAKAAGIDPAEVYYHGGDSFNVSALDGEISDYKVASSCGVSLRGMFGGKMGSASTEAFDADAVRQLIDGVKESATLLETDEQDEIFAGEERYPTIEKEESDVATTSAEAKIEKCLKLEALAKAADPRIVRVPSAMVASSSSEVILRNSYGLNLQDSGSYFFSYTSLVAKDGASTAVNGKVAVSSRFDGIDPEKIAADAAKETLSQLNASPVPTGEYRVIFRYDAMQSLLQTFWGVFSAENAQQNLSLFAGKEGENVAADVVTIVDDPLMKGGLATSAFDGEGSASRTKKVVDSGKLTTLLHDRKTARKQGVASTGNAARVGGRIMVAPTNLYIAAGEKSLDELMADVGNGVVITELAGLHAGANPSSGDFSLLSKGYTIENGKRGRAVEQITVAGNFYQLLKSICAVGSDLTFEGSSIGSPSVDAGTLKISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEX5</accession>
    <name>R7IEX5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceG_bac domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE50001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50001">
        <property type="protein sequence ID" value="CDE50001"/>
        <property type="gene ID" value="BN770_02228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025647">
        <property type="entry name" value="YceG_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14266">
        <property type="entry name" value="YceG_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceG_bac" evidence="1">
        <location>
            <begin position="30"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="515" mass="58819" checksum="C069E6F130945C0A" modified="2013-07-24" version="1">MACTNAWMKEASYEEILTPIAERGDDFRLFYHAFIRLKGVPDKQTYISDLFQFYQKFRSTGRRIAVVDDGLSLPGPEEAAQIRRHPYRSQEELIIDIAGNLPACANVELQRLMQQAFVRTMMAAAKAEPNLNRLLISAVYLLCWIRQYQAALFQGYKGSEIPCFVLMGGCRNQHDALFVQYLAQLPVDILILACDLSCPCTVQSDQLLELTGKDSMPVPKFPRDGGNVQMRTMASNAEQDLTSILYTDSGIYRNRQFSRADAITLQTTYDEVFILWSQELKYRANFSTVNQVVNMPVVYAKVSGVEDGKVEAYWQKIKLLLGDDTMLIPSLPYVVTGAANQFQPLAVKTLRNGRLKREEIKADRQYPFALLREELQEHMFDKVQLMLDERMIKGTFTNGTEYTVLATVLNMNRDIVRRLQSFDFTKKNPKMVVLCTGEQPCSLEDAILMTFLNLVGFDIALFVPTGYQTIERYLNGNYPVEHQIGEYVYDLQVPDFNALTPVKHSWLENILKRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF44</accession>
    <name>R7IF44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cellulase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000165">
        <property type="protein sequence ID" value="CDE50225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50225">
        <property type="protein sequence ID" value="CDE50225"/>
        <property type="gene ID" value="BN770_02328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436503" evidence="6">
        <location>
            <begin position="24"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="7">
        <location>
            <begin position="55"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="590" mass="64892" checksum="D194D4CE82235DC1" modified="2013-07-24" version="1">MQNMRKWIALFLTMLLPVLPAAAEEESTMLTGKTATEIVEMMGFGWNLGNTLDATGGNTADVTAQEQSWGNAKITPELMVRVKEAGFDTIRIPVTWYRYTSDDGTYTIREDFLQHVHEVVEWAREADLFVILNVHHEAWINEPNFAADAEKIGEQLTAMWRQIADTFADFDQHVIFEGMNEPRAQGTNYEWGGNAACYAAVNYLNQVFVNTIRKDAKGCNAERCLMIPGYAATSSPAGTAAIALPTVDGEAAANIIVSVHSYDPQTFCLQDTQTTFDPEKDGAKINRVFENIKETFLDRGIPVVMGETGATNTNGNHDERAKWAYCVAQNAQRYGVPIVIWDNGNNQTSGGECHAWIRRAVNPKLRSQATSVVYPQVLDALWEGKNSAAWGSALTEVRAAADESILWANADGLTSQKEWDSSYIQLEAKIEWFADGARIGIRYSGAGTPKIVLDSAEKSVWWIPVDAASVEQNADGTKTAWFTSEILLAEMRKNGVDSPAQLQNCYVIATNGKITAYRIKVEGMATALTTYHVNGSAIHQADLPDAPTYPHMTFCGWYTTPDYQPGTEVTGASGASDAWAKMALDMSVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFS5</accession>
    <name>R7IFS5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50281">
        <property type="protein sequence ID" value="CDE50281"/>
        <property type="gene ID" value="BN770_02344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="163" mass="17888" checksum="24CFA8C3625FF3E8" modified="2013-07-24" version="1">MKRFAIVSVVLLLIALLGVGAMYMTSNVTVIAQGVTALEAYRNYDLFTDLSAQVRAGAVVGTSFVAPQKLSSAEDYVFYTYTFRLENNTTLPAEMIEVQITPMSGDILQIGSDQVLTLPAHTIGDVTAIILTSKDMHAIREANITYYIWGIPFTIRTTIQTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFZ4</accession>
    <name>R7IFZ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ORF">BN770_02434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50545">
        <property type="protein sequence ID" value="CDE50545"/>
        <property type="gene ID" value="BN770_02434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE50545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="422" mass="46131" checksum="3EE78EB875282011" modified="2013-07-24" version="1">MLETFRKLWKIKDLQKKVLYTFLMLLIYRLVGVIPAPGIDVSRLNESNNFMQLPLLNMMQMMTGNAFGQMTIMAMGITPYINASIIMQLLAVAFPSLQRMQEEEGGQEKMARITRYVTVGLAVFQAIGLSRAGGYVRSGWYNTVLVGLSMAGGSALAMWIGERITDKGIGNGISLLIFAGIVSNLFNGITGNIYTAVANGTTTAWLSVLVILLMLVVMTFAVTYVDLGERRIPLQISKQVKGRRVYGGQNTHMTLKVVSVGVLPLIFAYSLLAFPGTIGALVAPNSGFTAWCNAYLSSGSWVYMILSALLIVGFTFFYSSISFDPNKQAKQLMEQGATIPGQRGKNIRDYLARTTNRLNLFAALFLAVLAVVPTLLTSWVTNLPFAASSILIAVSVSLETMRTVEGELSIRGIETDKDNGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGB2</accession>
    <name>R7IGB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49622">
        <property type="protein sequence ID" value="CDE49622"/>
        <property type="gene ID" value="BN770_02055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="60"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="215" mass="25166" checksum="9DC7C4E8502624AC" modified="2013-07-24" version="1">MFEKLLSRGERRFGRYFGIPKLMMILCIGMGVTYVADYLLAAYNISLSYYLMFDREAIFHGQIWRLVSFIFMPPSSSPVFLLISLMFYWYLGTSLQNTWGTFRFTVYYLCGMLGAILAGLITGYATNTYLNLSLFLACAVLFPETEVNLIIIPVKMKWLSLVYLLPVVQQLLTSNLWGILALVMSLLNVILFFYGDLIQRIRDFRRRQQWKRNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGC1</accession>
    <name>R7IGC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50363">
        <property type="protein sequence ID" value="CDE50363"/>
        <property type="gene ID" value="BN770_00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="263" mass="28981" checksum="7B0D859770E71FA7" modified="2013-07-24" version="1">MVTDPRKVLGVSETASQDEIKRAYRRKAKECHPDLHPNDPDAAKKMNELNEAYDMLMNPEKYANRQQQQNPYGGNPYSGNPYGGNSYGGNPYGSYGGNSYGGQQQGNPYGQQGGYDPFSDFFGGFGYGSYGGYQTQVNPPQEQAGDSDPVRAAIRDILAGRYASACSILQNVPSTGRNARWYYLSGVANHGAGNQIQALEHMKRAVQLSPNNATYQALLRQYQQAGQTYQTNASGYNTWAMDPSKLCMSLCFLQMFCPLCCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGF2</accession>
    <name>R7IGF2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="8" type="ORF">BN770_00228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000181">
        <property type="protein sequence ID" value="CDE50869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50869">
        <property type="protein sequence ID" value="CDE50869"/>
        <property type="gene ID" value="BN770_00228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="129" mass="14119" checksum="3C9992B7F5FEC836" modified="2013-07-24" version="1">MAKVDYSAVGRRKKAVARVRLVAGDGKVTINKRDIDNYFGLETLKMTVRQPLTLTGTTSFDVLVNVCGGGVSGQAGAIRHGISRALCKADPELRAALKKAGFLTRDPRMKERKKYGLKAARRAPQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGF3</accession>
    <name>R7IGF3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">LL-diaminopimelate aminotransferase</fullName>
            <shortName evidence="7">DAP-AT</shortName>
            <shortName evidence="7">DAP-aminotransferase</shortName>
            <shortName evidence="7">LL-DAP-aminotransferase</shortName>
            <ecNumber evidence="4 7">2.6.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dapL</name>
        <name evidence="9" type="ORF">BN770_02364</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23988"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="EC" id="2.6.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.83" evidence="4 7"/>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50398">
        <property type="protein sequence ID" value="CDE50398"/>
        <property type="gene ID" value="BN770_02364"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033362">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01642">
        <property type="entry name" value="DapL_aminotrans_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019942">
        <property type="entry name" value="DapL/ALD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43144">
        <property type="entry name" value="PTHR43144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03542">
        <property type="entry name" value="DAPAT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="8">
        <location>
            <begin position="35"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="409" mass="45304" checksum="9DB5412941F91E9F" modified="2013-07-24" version="1">MFHINDYFTRLPGSYLFAEIARRVKAYSAAHPNADIIRLGIGDVTRPLAPAVIEAMHKAVSEMGVQETFHGYGPDYGYDFLVNAIREHDYASRGVQVDFDEVFISDGAKCDVGNIQELFSTDAVIAVTDPVYPVYVDSNAMAGRAGEYADGKWDRLVYLPCNAENGFVPALPDKPVDVIYLCYPNNPTGTVLNREQLTKWVNYARENGALIIYDAAYRAFVSTPDIPLSIYEIDGAKECAIECNSFSKTAGFTGTRCGYTVVPHAVKGLNAKGEPVEMNALWKRRMSTKFNGVSYPVQRAAAAVYTEEGQKQIQETIDYYMRNAKIIREGLTAAGITVFGGVDAPYIWLKVPAGMDSWTFFDRLLDECHIVGTPGSGFGPSGEGYFRLTAFNTLEKTEQAVERIRSWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGV2</accession>
    <name>R7IGV2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49787">
        <property type="protein sequence ID" value="CDE49787"/>
        <property type="gene ID" value="BN770_02137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="252" mass="27019" checksum="724965A6CD1A70A1" modified="2013-07-24" version="1">MLTVQRVYELIDALAPFDTQADFDNSGLLVGNPQAEVTGIHLALDVTDRVIDDALAAGANLIVTHHPLMFSARKRLTEADYEGHLLIRLIANGLSLIAAHTNFDQASGGMNDTLAGLLGLENIVGEGFLRVGDLSAPMTAEAFADFAARQLGDTVRVMGHREALIHRVGLCSGGGCDEWADAHAMGADAFLTGEVKHHIALDASYHGVVLLEAGHFATENPGIFALMKALQNAPDIVQWKMHISRSERSAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH80</accession>
    <name>R7IH80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC-type sugar transport system periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50786">
        <property type="protein sequence ID" value="CDE50786"/>
        <property type="gene ID" value="BN770_00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435935" evidence="1">
        <location>
            <begin position="27"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="515" mass="57977" checksum="E64287E5A70094AA" modified="2013-07-24" version="1">MRKNAFFLLLLLLLLLTLSGCGDSIAPETEKVSLTALQYELENQTLDFDNMWFFQQIEEQTGVHVDFDVVKLSDWTNRVNLMFASGRYHDLILRGSLDVEDYGVTQHVILPLDDYLEEYMPTYFGRLSIDNAGRTLPSSDGKMYYVGFLLSQGINTNGHFFINKTWLDKLGLSVPTTTEELTEVLRAFKNGDPNGNGLADEIPYEATFADVNTGLYNAFSAFGIPMNEYFVQLSADGKVLFMPEEDGFRACVEWLHSLCQEGLLDVESLTQGSNLWAAKVNQQKAGYFTYWRLINTALSEDIAADYEVMLPVHAEGYTARLARTKDEIEFGAALTIQNHDIPSSLRWLDAQFETENMLVAQNGKIGDTLILRGDGRYEVAYVPAGNELYKTVPIICGQFFAPASYYASVYVPAAHRQEKSAYCALYDESGVLEEVPYTLLINTVPITSEESARIQQLYTSLKSAVNAYLVEFVTRGVTDERFADFLTELNSVGAQEYVSLYQTAYDRYMKGLSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH95</accession>
    <name>R7IH95_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IU_nuc_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50806">
        <property type="protein sequence ID" value="CDE50806"/>
        <property type="gene ID" value="BN770_00208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="4">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="315" mass="34596" checksum="72049606AAAF8CC1" modified="2013-07-24" version="1">MRKIIVDCDPGMDDSSAIIMAVKNPNLDIQAVTTVNGNYPVDITYRNARRIMRMLGREDIPVYRGCSRPLVRDIPNDPFTHGRDGQGESFLPDSELPENPTHAVNAIIDLIRQQPGEITLVCLAPMTNIAMALRLAPDIKDKIVEVIAISGAFGLNEASFLNATGDTPQSEWNVYVDPEATKQVYESGLKVTAIGLDVATYFSVDFTDEDLARLAASDKPEAKFLHQAISFVHGRGFQAYCAVIDCMAVAATADPTLLKSVRGRVGVSTQDGLTLGMTIMDRRHHHVWTNLPEINVAVSADYARFLHGLIEDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHD2</accession>
    <name>R7IHD2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Relaxase/Mobilisation nuclease domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000180">
        <property type="protein sequence ID" value="CDE50851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50851">
        <property type="protein sequence ID" value="CDE50851"/>
        <property type="gene ID" value="BN770_00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="439" mass="50840" checksum="A2DEB37544F27ADB" modified="2013-07-24" version="1">MNPEKTDGGILISSHACSPETAAEEFMLYRQEYLNTTGRKRGDEVLAYHVRQAFKPGKITAEKANEIGKALAERLTDKQHAFVVATHIDKQHIHNHIIFCATSLDGRQKYRDVKRSAKELVQISDALCEENRLSVICNPQDKAVPYDKWAVNWKKSSHRDDLRIMINAALRHRPDGFDALLQMLEDAGCRIRRGAHISLKPPDGQRYIRLKSLGPEYDEDTLRQALAGDHVHIPKTPCADYSKSQIKRLIDIEDKLRAGKGKGYLVWAERNNIDAISQTVIFLKEHHLGLPEELEQQIDNLQSAHDEKKASIRQAQNRMKEINRQRQAIRDYRRTKEIYTQFKESGWSAKFYQEHRAEIEAHKKAQAVYELHDGKLPTLKELTAEYVALKEQLDAYKPDLAELKSKLTDLKHIRYNYKILIRDIPQTDQYHRKGDRIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHM5</accession>
    <name>R7IHM5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000193">
        <property type="protein sequence ID" value="CDE51130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51130">
        <property type="protein sequence ID" value="CDE51130"/>
        <property type="gene ID" value="BN770_00291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="234" mass="26747" checksum="BF92FFE0336EBA01" modified="2013-07-24" version="1">MLLIAIVDDERSDSSALKALVDIYFQQNRQAYMIHVFNGALDFIRSTENHDIVFMDIRMDKLDGLEVARIMRKINTDSVLIFVTHMAQLAIKGYEVDALDFIVKPADQGSINYVLDKAMKRLEGVSNAAFALKTSDGIVSLSTNDIIYVEVFDHNLVYHTTKGNYDIRGRLSDVMKRLDPKRFIMCNRSYVVNLRYVSNINNDFLVVDGTQISISKSHRKEILQHFSNFLGENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHS0</accession>
    <name>R7IHS0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51016">
        <property type="protein sequence ID" value="CDE51016"/>
        <property type="gene ID" value="BN770_00263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="230" mass="25951" checksum="153FABE874866FAE" modified="2013-07-24" version="1">MTIAIVDDELETRQYMQGLVTQYLAETGRMAQLVFYPDGASFLVGCEHPDIVLMDIDMPGMDGFSTAEQLRRSHPDAILIFTTRLSQCAIRGYEVDAIGFLVKPVTLPGLTVKLNKAFKRVEYRQSKICLKTKDSILFLEKNEIYYAEGSNHHVIYHTAQGEFPVRSSLQEAEEQLGAEFSRSSHSYIANLGFVTMVGKNDVTVHGEAIPLSRAMRRDFLNAVNRYYGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHV1</accession>
    <name>R7IHV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000215">
        <property type="protein sequence ID" value="CDE51354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51354">
        <property type="protein sequence ID" value="CDE51354"/>
        <property type="gene ID" value="BN770_00394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="336" mass="38500" checksum="3960E3ABCD887C80" modified="2013-07-24" version="1">MNKYNGLLSAVAQKYNIRRALQEAENDWKTRLIYSVCGMMAYASLWDETEDEPVSIVHLKRKVRSMLSSYKSMYPELSNSLPYISAELEDEIAGLFLSTGMVYHRPNRIAPSMKHEESHCNIVFQRGIGLDSISCVSGIGFYSKLECISNPDGIKTMFGLEQQALWDLWNSTLTTASWKAAPSLEQNTEYLRLKPPFSRGYWENKPDTTGLVSILRTGIKGSQLYYIYRYSDNAMEISPLPQWQVENHHYRSLACACLHSYGALPPIEYVKDGALVHIWMNYLLPPHELEFVKLYSWPEVCTSLPCDFKRKLSTEVFSAMKTVLSDQGYEFKGEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHX1</accession>
    <name>R7IHX1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argS</name>
        <name evidence="12" type="ORF">BN770_00040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000202">
        <property type="protein sequence ID" value="CDE51210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51210">
        <property type="protein sequence ID" value="CDE51210"/>
        <property type="gene ID" value="BN770_00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="11">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="457"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="572" mass="64646" checksum="60C1664940D9A0D5" modified="2013-07-24" version="1">MDMKTKLAGLMAQCLTDTWPDAQGLLTAEEIRGLLAVPPDPKMGDYALPVFRLAKALRMAPPKIATTVVEKWSHEDVARAEAVNGYVNFFLNRVNFAAETLESVLKAGENYGSSDMGNGKTICLDYSSINIAKRFHIGHLSTTMIGHSLRRIYDFLGYKTVGINHLGDWGTQFGKMICAYKLWGNEKEVEKGGVNELVRLYVKFHEEAEKDPTLDDQGRAWFKKIEDGDEEALRIFNWFKALTLRDTERVYKLLGVTFDSYAGESFYNDKMDRVINELKEKNLLTISEGASIVDLSEDNMSPCIILRSDGATLYATRDLAAAIYRHDTYHFDKCLYVVAYQQDLHFRQIFRVLEKMGYEWAKDCVHVAFGMISYEGQALSTRKGHVVYLEDLLEQAQKKALDIINEKSPNLPNKEDVARQVGIGAVVYTDLSNNRIKDVDFCWDRALNFDGESGPYVQYTHTRCCSVLRKAAEMSLPEADMNALTDDEAQALLRLLGRFPDVIKEAAEKYEPSMITRAVTDIAQAYNKFYYEHRILDGEPATAAARVALTKATKDVIKTGLWLIGIEAPERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7II03</accession>
    <name>R7II03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4340 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51419">
        <property type="protein sequence ID" value="CDE51419"/>
        <property type="gene ID" value="BN770_00426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4340" evidence="1">
        <location>
            <begin position="96"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="355" mass="38765" checksum="7F5BF6EB938D66A4" modified="2013-07-24" version="1">MDFADGSSHTLRIGSTPQYENSWQYAQLDGDTRLLSVSRGLAEECYVTRGSLHSIEQLTIHADRLDEITLLNAEGEITQQWRLNGAITNADAQDRWMLTTPVSYPADGTAMNTLRKSAANIRLGEYIADATAESIARYGLDMPRLVIRLHQAAGTIGAVGTTGSYATTDYPEATITLVIGEQESDLVDYVLYDGGIYRCSTLLLRGVMNADWQETITRYPVLTALGNLASLSRETADGVDTWVITRTEQVAENNELVTDGEGNQVYDITLMKNGESADYTAFSAAYNQLMMVTMSGRLPDGWTAADAPHTVWTFTDVDGTVHTVALTRYDAMHDAVAIDGVALFYLIQGGFSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7II54</accession>
    <name>R7II54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50242">
        <property type="protein sequence ID" value="CDE50242"/>
        <property type="gene ID" value="BN770_02330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="259" mass="29460" checksum="724B77DCB070EF9F" modified="2013-07-24" version="1">MEERKCVGWQEQETSRLFSAVQEARGSGAPLRQVFEDLSVDLGRKPNSIRNYYYACLRNQEQNTPRVQAFIPFTEAETHDLLRQVLTGCGQGMSVRACVMRMADGDHSRMLRYQNKYRAILKHHPEMIAQVRQELLAEGVAAPAQGKNPPDEAENRAASQMMAEPCVLKMLEGMKELLCRASAAEEKEQLQRSLDRMRVEQDLRRIAWEKDYDAAVQLIREMRACLESVRNSLDGEKRCDVEDCLAKAASFPNKHAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7II60</accession>
    <name>R7II60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000198">
        <property type="protein sequence ID" value="CDE51161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51161">
        <property type="protein sequence ID" value="CDE51161"/>
        <property type="gene ID" value="BN770_00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435958" evidence="2">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="427" mass="48423" checksum="BC91174A413F16D2" modified="2013-07-24" version="1">MKKVFALFLFFLLLLSVSSAENVSSVRILCTDYNYSAFQDYAAAGHDVNFRNGSINDIATALASRDPDIDVFVFQTRSGLDQIKKQHYYYPLTDASDLMDKLGDLYPAFQNALMDNGNLVGWYVDAQPWGWQVLSPDLLEELALSAPTTFDELLDVSKVLFDSGLLSRDYVLMLEYRYTQQDMLTFYLRQFLIASERVDGQINFLRPEFARIAEKIRNTVPETSKENLFADYEVFTSSAASVTPSTYIELIPSVLDDAPSGLYYLTVVAVINPYSNNIDGAIDLMHYLATYESATSYLWDASLNQPVIRSDYDELVARYQGEIARLEAKENRTTQDESDLDYARSGLDYITEHPYSVSPEDIAYYQNLVQYAYIPGDSPVTFDDALKTLMQRYLNGAFDAEGFARACQEHVNTVYLEMGLTPMYVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIC9</accession>
    <name>R7IIC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50332">
        <property type="protein sequence ID" value="CDE50332"/>
        <property type="gene ID" value="BN770_00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="750" mass="84799" checksum="73B58F8E1BF85155" modified="2013-07-24" version="1">MGIDMIRKRDGREVPFDQDKIEQAIFASFQASGSARGHETSRKLTEEVVRLLENNENISAIPSVEQVQDTVEQVLMRNGFTRTAKSYILYRAERSRVREMNSRLMRTFGDIVFKDASESDIKRENANINGDTAMGAMLKFGSEGAKQYYEKYVMDPRFGQAHMDGDIHIHDMDFYTLTTTCCQIELKSLFKGGFSTGHGYLREPQDITSYAALACIAIQANQNDQHGGQAIVDFDYGMAPGVKKTFIKRYRMNLSRALELLLNDAECDAHANELVAQTKAENLEPTLEENADHRARMAELLTKYVADEQMIARILDFTQRRSEQETDKATYQAMEALIHNLNTMNSRAGAQVPFSSINYGMDVSPEGRLVMKNVLLATEAGLGGGETPIFPIQIFRVKEGVNFNPGDPNYDIYRLAIRTSAKRLFPNFSFVDAPFNLQYYKPGHPETEIAYMGCRTRVMGNVYDPDREIAPRRGNLSFTSINLPRIAIEANGNVDVFFKVLQERMELVIDQLNERFRIISNKRVKNFPFLMGEGVWIDSEKLSWNDKVGEVLKHGTMTIGFIGLAEALVALRGKHHGEDEESQKLGLKIIRTMREYTDKVSAETGLNYSVIATPAEGLSGRFVRLDKQRFGIIPGVTDREYYTNSFHVPVYYHCTAFHKLSVEAPYHALTNGGHISYVEMDGDPLKNLDAFEKIVRYMHDIGIGYGSINHPVDRDPLCGYNGIIDDTCPCCHRGETTRVTERIKRIKVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IID0</accession>
    <name>R7IID0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000228">
        <property type="protein sequence ID" value="CDE51549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51549">
        <property type="protein sequence ID" value="CDE51549"/>
        <property type="gene ID" value="BN770_00492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18319" checksum="C5C054EE9679679E" modified="2013-07-24" version="1">MQQLYLTGDGASASAAQLMNALNVPFSGFRLTPVHLGGSLRGEALHLLLPPPKPRLNDVLCRVRLTEKDWLLLPQVMEEIAAPGLCGTFSTRTPILIDRIEPEMLVCPAFCDALMQVQAREQLAIFVVADGAEKPLQQMMPENRQRWFSAPDTPAETLVEAAMLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIH3</accession>
    <name>R7IIH3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51236">
        <property type="protein sequence ID" value="CDE51236"/>
        <property type="gene ID" value="BN770_00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="384" mass="42346" checksum="F82D63EEC30D3779" modified="2013-07-24" version="1">MQGRNPSTAIPDPDQKRKQRLRMLRNCTIVVLVVVLIVLAVNLVRYLTRSRSIGVYSLPCFAHQDVTVFRDGVVYYDGESIHCVGATGTVLWSYPVGSGASFSVSDKYLIAWSGTQLFIVNENGRPTYNEPMTSEIQFARIGNTRAVIVLGDEINPEVMMVDLNGQLLDSEKGVFEGKMLLDCGFFGTGEEYCWTLSADVYSPALATYLHTFQVNKMNTGNVNLGDHLVYKVFYTGSKLYVFDTQQLTTYDYRGVQDTSGSQLIYGWRLMNHSLSARGTPQMLFAPTNQTSSEMVITELRVLAGSVDNHITLPTTCVGAAIDSRRIYAFSPTYLFTSTLESQRFVAYAASLPDGRSVTSLIGITSGGYAIVTSGTEVYSITLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIM9</accession>
    <name>R7IIM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 3 N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51306">
        <property type="protein sequence ID" value="CDE51306"/>
        <property type="gene ID" value="BN770_00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="539"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="574" mass="62275" checksum="3BC40E6ACD3D65BD" modified="2013-07-24" version="1">MKVTRQADSDSYVVTLTVTNTGSAAGREPVQIYLQKPYIEGGLEKASVELAGFTKTKLLQPGESETVRVTVNGEFFRTYDAVDAQTYVLDPGDYYLAAGYNAHDALNNILASQGFSPESTGGRMTAAGNASLAAVALHLDQRDAVTYAVAAETGEPITNLFDFADINRYEHRGDNQVTYLSRADWAGTWPKKPVKLSVATEGMMSDMASHKPLPNDPEAVSPLYNIDSGSQLIAMRGLPYDHSTWDILLDQLTYEEQALLVTNAAFGTSALDSIALKETKASDGPTAVSASITAVSFPNEGIWASSFDVELIERIGDFLAEDARLNGVDTMYAPGVNIHRTPFGGRAHEYFSEDPLLTAYAAMAEVKGMQKKGVIPVLKHYAFNDEESARNGIGIWLNEQAAREIYLLPFEYAMRPSMGAGALGAMSSFNRVGALWTGASKALQLDISRNEWNFQGYFITDMASSNGALFMTFDDGVFNGTDLFLGSGSKTALKEWKSNIPFRNRVREAVHRVLYVTVNGNAVMNGVSPSSQVVLVTPWWAMALLAAIAASAVIALGSVVVHIWFILKDKRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIR9</accession>
    <name>R7IIR9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TsaA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000200">
        <property type="protein sequence ID" value="CDE51193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51193">
        <property type="protein sequence ID" value="CDE51193"/>
        <property type="gene ID" value="BN770_00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041369">
        <property type="entry name" value="TrmO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18389">
        <property type="entry name" value="TrmO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="229" mass="26240" checksum="75718E6B45AD6947" modified="2013-07-24" version="1">MEIIARIENGFREKFGVPRQSGLVPEVISRVVMAEKYSVREAFRGIEDYSHLWLLWEFDRAQQDDWRPTVRPPRLGGNTRLGVFATRSPFRPNRIGLTVVRLIRMEEENGRITLVVSGADLMDGTPIVDIKPYLPYVDSVPDAIGGFTEQTERHRLTVDFPEKLKKYVPKQNLPAVMGLLAQDPRPAYQHDGKRVYGVPYGEVDIRFVVEGDMLTVVEVVPYTEKEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ50</accession>
    <name>R7IJ50_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51660">
        <property type="protein sequence ID" value="CDE51660"/>
        <property type="gene ID" value="BN770_00560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="221" mass="24203" checksum="7CB10E135021DE0A" modified="2013-07-24" version="1">MVTLADIQKNEDIKALISAGNRYLAAMGFTEHGPRHVSYVSRTAAGILAALNFSPREVELAAIAGWVHDVGNSVNRHDHGPLGAVLLLPILRETGMAMDDVMEIITAVGNHEEQSGFISSAVSAALALGDKSDAHKTRVRGGKPDLNDIHDRVNFSIQENRVIVDPVKRIIRHELTMDESSSVMEYLQIYMSRIVMCEQAAAFLKCSFDLVINGQTINNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJI2</accession>
    <name>R7IJI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Processing peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000243">
        <property type="protein sequence ID" value="CDE51760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M16.A15"/>
    <dbReference type="EnsemblBacteria" id="CDE51760">
        <property type="protein sequence ID" value="CDE51760"/>
        <property type="gene ID" value="BN770_00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="167"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="412" mass="45683" checksum="0C72D32D46445EF3" modified="2013-07-24" version="1">MRDEWVLPNGLRVLGERLPHLRSVSIGAWMHVGSMMETPEENGLSHFIEHMIFKGTTKRTVRQIAEEMDAVGGQLNAFTGKDCTCCYAKVIDEDIELAIDIIADMVMNATMDEKELNKERGVVLEEISMDEDSPEDLVHDLLAKAQFGTQSLGQPILGPAEQVAAYTRANLMDYKNKHYLPRETVVALAGNYEPTQVQALMEKYFGTWQAGESALVVPKQQVLTGRRVVKEKDTEQLHICLGYPGYAYGTDDVYAVAVMNNVLGGAMSSRLFQRIREELGMAYSIYTYPNSYQGIGTYGIYAGISPKNGDKVLEEIDSELKRFLKDGMTDKEFRDSKTQLRSGYLMGLESSGSRMQAMGRSTLLNGHPTDHQKTIAAIEAVTPEMVMDVAHKVLTAEPCLAVAGKGAEKYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJK9</accession>
    <name>R7IJK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51508">
        <property type="protein sequence ID" value="CDE51508"/>
        <property type="gene ID" value="BN770_00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="398" mass="44114" checksum="C32AB4F67B08161D" modified="2013-07-24" version="1">MTLQDTVRYFTEETEILPCLSVTCGGAGLCVQARGGVINEQGTPVSDRTLFDLASLTKLFTGLLTMRLWEEGKLDLTCPVTDYAPQYRYLSDMPVEKVLGFEIGLTTPERIDTQKTPEAAKKQLWAVQPGEIRGRAYSDIHAMVIRDVIEGAAQSGYGAELTRCILRPLEMAETFLHVPEKRRADCISCRGEHRIEQGKHILRTDAQPGIPHDPKAAKLYPEIMGHAGLFSTQGDMVKFAQGVLREQVISKMTIRKMARNRTGFRRADGTYQQYLGALCYVKHPVQYFSEIPAYESDEAIGLAGFTGQHMSIDIGTGVFTLFLGNRVMNRLTVLVPEAGKSLTDYGLQADGRGSIVWDDGTRVVSSVNYVHQKDAHFHQAVADTLGLPAWRRAGTAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJT9</accession>
    <name>R7IJT9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type transport system substrat-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51885">
        <property type="protein sequence ID" value="CDE51885"/>
        <property type="gene ID" value="BN770_00670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448357" evidence="1">
        <location>
            <begin position="31"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="125"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="832" mass="93052" checksum="544CEB1DF20B21CA" modified="2013-07-24" version="1">MKKILSLVLSACMMLSAAALAEGTFTPADSYDVGERVYNAGTVTLEKSEGSAQTVSTDQYVGEAGKDYTDEKVYTYNSYTPGINSSLNWDPLSWETNEDTDILNNVSSGFYTFVLNSEKNGYSVMPELAAEMPVDVTAEYVGQYGVKEGETAKAWRIALNKLAKWEDGTPITADDYVYSMQQLLNPKMLNRRADSYYAGEFVIYNAKNYLYAGKTTYDLIADTAENLVAAGTDVYLDMSAWGMVGALDAEGNPAPQYVNIADDTMYRDASVEDETAAEAWVSAKYLFDNYFAAGQQYESMQAQYLYTASVADAATWDEVGFKKVDDYTVDFILANPVNEANFYVPYNLSSSYLVYKPVYEACKTFYKDGKEVATEEEADEVKTKYGRSVENTVSYGPYKLSSFELDKEYTLTRNDNWYGYHDGNHVGQYQTDIYKVTCIADHATQVLAFEKGEIDDIALQADDLKKYGNSKYIKYGPNNGYTTKLTMNTDYEKLLSHGTNSQVLVIPEFRQAISYSYDRKEFASSFTAAGTAGFGLINELYCYDPFTGALYRDSEPAKAVLCRLFDLTWGEGGDYDTLDEAYEAMTGYEVEKARALMAVAYDKAVAAGIYDGTSDIKIDLRVYQSDAIYVNMFNYLNAALKNACVGTPFEGKVEMTMTVDTDYYKTMQSGNADMIFTTWGGATMAPFGVFGNCYTDDAYGKGNQNEYGYDTTTIDIVYNVEGVGEITDTLQNWANWCNSQKVPSIEEKLGKFADYTYDTRLQFATAVEGAFMNWYPCSSIYYRNTASMNSQKVNTVVDTYVTLIGFGGIQYMTYNYDDAEWADYIANNTLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJV0</accession>
    <name>R7IJV0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ORF">BN770_00508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51593">
        <property type="protein sequence ID" value="CDE51593"/>
        <property type="gene ID" value="BN770_00508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="4"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="335"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="489" mass="55942" checksum="D245E50BFA0BF19B" modified="2013-07-24" version="1">MNQEVRTRFAPSPTGFMHLGGLRAALYGYLFARKNGGKFILRIEDTDQVRFVEGATEVIYDTLRRCGMNWDEGPDVGGPVGPYIQSQRKELYLPYAQQLVKTGHAYYCFCTKEELEERRAACEAKGEVFKYDKHCLHLTQEEIQRKLDAGVPYVIRQNAPTTGETSYDDLVFGHMTFPNDTLDDMVLIKQDGMPTYNFANVIDDHLMGITHVMRGMEYLSSTPKYNLLYEAFGWEIPQYIHMPPVMRDSQHKLSKRDGDAYFSDYVDKGYLVEAIVNYLALVGWNPGDDREFFTLDELVEAFDIHRINKAPGIFDVKKLTWFNAEYIRRLTPEKYLEMVTPWFDKVFGDSSKMDYKRLAELMQGRTEVFNLVPDMVRFLAQLPDYDSAIYINKKAKTNKEACLKALNLLRPVLDGITEWTEPVIHDTVMAAIAEAGMKNATALWPLRIAISGQQSTPGGAIEIAYLLGKEETLRRVDDGIRRVSEMPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJY5</accession>
    <name>R7IJY5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="12" type="ORF">BN770_00531</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51628">
        <property type="protein sequence ID" value="CDE51628"/>
        <property type="gene ID" value="BN770_00531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="193" mass="21759" checksum="E5D82D13D47870F3" modified="2013-07-24" version="1">MAKLYFRYGAMGSSKTANAIMVQYNYEERGQKVLMLKPKLENRDGAVIVRSRCGLETACRFIEDVTAADAQGYGCVIIDEAQFLTKAQVEMLVEMVDDYDVPVIAYGLRADFQNNFFEGSQWLMAWADTIEEIKTICWCGRKATCNARVVDGRVVQEGEQVVLGGNGQYVSLCRKHFRRGELGDFKDLHLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKW5</accession>
    <name>R7IKW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 3 N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51227">
        <property type="protein sequence ID" value="CDE51227"/>
        <property type="gene ID" value="BN770_00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="586"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="818" mass="89532" checksum="430B596A4244AB06" modified="2013-07-24" version="1">MKHGDLVSQMTLEEKCALLAGKDVWHTREIPRLNIPAITLSDGPSGLRKQAGEGDHLGLNASTKATCIPSAATLACSWDDTVSEAMGAVVGRDAANQGVDVLLAPGLNTKRSSLCGRSFEYYSEDPYLSGKLAAGFIRGAQKQGVSACAKHYAANAQELLRMHSDSVMDERTLREMYLTNFEIAIKEGKPGFVMTAYNRVNGVYANESRHLLGDILRGEWGFDGAVVTDWGGSNSIVEGVREGMNLEMPAAGDDSPCQLVEAAAAGDDSPCQLVKAVKDGTIDEKIVDERVDQLLDFVLAENKSGESSFDAAKQHQAAEAAAEKCLVLLKNDEHLLPLKKDARVAVIGEFAARSRYQGAGSSMVNAAQVDDTLPLLDEFFPARVGFAQGFERLDAPNDALADEAVQLAKTADCAVVYIGLPECFETEGLDRTHMRLPENQIALMKKLRAVCKKMVVVLSCGSAVETDWAQDCDALLYAGLGGEAVARSVLRALVGEITPGGKLAETWYRHYADAPVSHYYPGTEATSEYREGLYVGYRYTESADVAPAFAFGHGLSYTTFRYDNIQADNAGVSFDVTNTGDCAGDEVAQLYIHKPNAEIFRPAKELKGFQRVHLEKGETKRVTIPFDGYTFRYFNVRTNRFEVEGGEYELLIGASCRDIRLTAKHTEQGTNAPNPYAQLAVQSYRTARVTDVSDAEFAALLGHAIPPHLWDKTQPLTLNDTVTQLSYAKNPLARLIYRILTRMKNKATAAGKPDLNLLFIYNIPFRGMAKMMNGMVSMAMAEDMLLMVNGHFFRGCGRLIHHFCHRPKLNLNPDKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKZ6</accession>
    <name>R7IKZ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000207">
        <property type="protein sequence ID" value="CDE51272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51272">
        <property type="protein sequence ID" value="CDE51272"/>
        <property type="gene ID" value="BN770_00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448402" evidence="1">
        <location>
            <begin position="22"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="227" mass="24075" checksum="5A6D6D849C8798D1" modified="2013-07-24" version="1">MKKFLAIMMALSMMLCAFAVAETVSPVASTVASPVASPVADMVGDPADLPAIAAVLNGGSEVYVPSDKTNKTLQDALNDEFTEGAGYDSFAVLDVDGDGKLDVVLNVTVNGEVLGYLVLTSADEVICAYGFYYRAMIGLKEDGSFSFSSSAAESGVATFYKDENRDAQYNELAESKLDENENVVYFVNGEAADEDAFTAVINAQNEKADVTFVPATAENLALYLTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL02</accession>
    <name>R7IL02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51282">
        <property type="protein sequence ID" value="CDE51282"/>
        <property type="gene ID" value="BN770_00357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="309" mass="32696" checksum="C7C41167A08626C2" modified="2013-07-24" version="1">MEIMKLLNALPGAVSQGVIWGIMAIGVYITYRILDVADLTVDGSIATGGAVAAVLIISGCNAWVALVAAFVVGMLTGLVTGVFHTWMGIPAILSGILTQLALYSINLGIMSNKANTAVNANKYDLLVSLRNVRNFSLDNPILLLLIITAAVIALLYWFFGTEYGCALRATGANVNMARAQGINTGRAKVVGLMLSNGLVALSGALLTQYQGYADVSMGRGAIVIGLAAVIIGEVLFGKIFRNFATKLIAVSIGAIIYYIVMQVVLWLGLPTNYLKLLTALVVAMFLAVPHWKSQLFTARSARKGGKQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMJ5</accession>
    <name>R7IMJ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="9">CMK</shortName>
            <ecNumber evidence="2 9">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ispE</name>
        <name evidence="12" type="ORF">BN770_00646</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 9"/>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51837">
        <property type="protein sequence ID" value="CDE51837"/>
        <property type="gene ID" value="BN770_00646"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="86"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="11">
        <location>
            <begin position="200"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="291" mass="30785" checksum="4B661B3C2014D361" modified="2013-07-24" version="1">MLRIGARAKINWTLDITGRRADGYHLMDMLMQSVTLADEITLEKTADGIITLTTGGTPLLPADEHHLALRAARALQKATSCPLGARIHVEKHIPVGAGMGGGSSDAAGVLVGLNRLWETRLTRAELEDVGLTLGADVPFCIRGGLTRTRGIGEAMQELPCGRCFPLVVIQPCGGLSTRDVFAAYHAQAVSFRPDNDAAQAALADGDLRALSPALGNVLQPVSEQMRPAIADAIADLRKCGAAAALMTGSGSAVFGAFETEESADAAFAALEKRYDRVFRCETCMESVIEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3K5</accession>
    <name>R7I3K5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46484">
        <property type="protein sequence ID" value="CDE46484"/>
        <property type="gene ID" value="BN770_00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="219" mass="24819" checksum="884C77CFDAFDF94D" modified="2013-07-24" version="1">MARIRDDVFSGVYPAESQIPSEQEMCARYGVSRVTVRRAISELTDEGILRKQQGKGTFVCTPKLCRDLRDINSFHECCRMQGVTPGTRLIHAQLSHADERTQRELELPDDRVVEIERVRTADGVPVMLETNSFPLAYSDLLQADLSQSLYAVLEGRGITPKRGIHEISLHYATNAQARLLEVDPGQALLLLREVVFDQHGRPLHTSHQLIRGDRFTFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3P1</accession>
    <name>R7I3P1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46524">
        <property type="protein sequence ID" value="CDE46524"/>
        <property type="gene ID" value="BN770_00918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="471" mass="52597" checksum="01FD97EE73F101E4" modified="2013-07-24" version="1">MGKGNILPRVQVALVLRGGRTIGGIINSCVRGNREARRDRSVVLAGLEGQFRRIGIAQERVIAVLRARGDRFVIKKALAPDAPAVGHICWNLRQHHFVQYFSRRIRQRQHLAAALFQFEGGVQFASVAQGRIAVAPDDLVLTRIDGCSLWKLPFSCASNIVGQAVAGQIDRLIGGIVDFHPVSIAAGGRLDRRIIGRHNFGHIHACWVEGAEDGIHPARSLLRIRQTGRRVLRDDEHAVFVARIGRILRHVIQRHAVNKPSAAVRQHHIIMLRAEAEVRVRHGIRVGVGRFIAVAVDQIVPVRLNRRAFREAPLKRLAFVVAQRVIIQRNHLIGRVVQLHPVADVAACIGVAGQRIRTDLVDDDRAVRHQRRRAVFLMSARRVLVAGAVLVCCAPAAVRQARIALVHPQNRGFHRVNEVSVRVIEVQFLAVGGNGELCVHRLSRNRLIFLVAQHNHAFARRQLHIREQELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3Q6</accession>
    <name>R7I3Q6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endopolygalacturonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46235">
        <property type="protein sequence ID" value="CDE46235"/>
        <property type="gene ID" value="BN770_00793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectate_lyase_3" evidence="5">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="516" mass="56776" checksum="F2BF84D41D3B41AA" modified="2013-07-24" version="1">MEISKLFVQARSATVQIADGGLYHTKAVYQLFLNGQAAGTADTAVTSLYDLQPETEYVLSVRLGAEEVGQCAFRTARESYTLNVRQFGAVGDGVHDDTAAIQAAILHCPADGRVLIPAGRYHVLPLMLKSHVRIELRRGATLLLETDRSKFPILPGMILSTDETDDLNLGSWEGNPLDMYAAFISGMDVEDVVLYGEGVLDGQGDKSDWWQNCKVRRGAWRPRMLFLNHCKNVTVQGVTFQNSPSWNLQPYFSKDLRFLNIRVNAPANSPNTDGFDPESCDGILLAGAHFSLGDDCIALKSGKLYMGQRYKTPCQHIEISHCLMENGHGGMTCGSEMAGGIAHVRLHDCLMRNTDRGLRVKTRRGRGQQGVIDDIVFENVRMEHVGTPYVVNCMYFCDPDGKSEYVQSREKQPVDERTPRIGTVAFRHVTATDVTCAGYFLGLPERPIEAVVMEDVHISCNKDATPMQPAMAQGVPYLARKGLTAINVAKIVLKDVTITGQDGAKLECDGIGEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Y1</accession>
    <name>R7I4Y1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46695">
        <property type="protein sequence ID" value="CDE46695"/>
        <property type="gene ID" value="BN770_00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2" evidence="5">
        <location>
            <begin position="149"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="6">
        <location>
            <begin position="256"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="555" mass="62318" checksum="6EB0A0B6DAB7F4EE" modified="2013-07-24" version="1">MSDRTFATHQIRRAIPVPTLWDFAALDTTAPVPARLPVPSAWELVPALHNYRGRAHYTTRIRCGGNIRLYFGGVSFRARVLLDGNEIARHYGAFTAFETVVRHLPDGEHALTVEVDNRFGEDSALHVPNDYYSYGGITRPVVIEQLPDVFVERVGITTKRAADGWTADISATIRNLADDDASADVTLTLAGQTFTQTAHIPADSTAIIRIPDAHYADVTAWTPDTPALYALRAEIREGNQVLDDLIDRVGFREISISGMDLLLNGEKLRLMAFNRHEEYGAFGCAVPLQAMAQDILMMKDMGCNCVRTCHYPNDPRFLDLCDEMGLLVWEEAHARGLQEEQMRNPNFMPQTRQCVREMVAQHRNHPSIFIWGCLNECADNCDYGADCYREVYALLHDLDASRPMTAALLERPGSLVYGDSDVVSVNIYPQWYHNTPVAESLAQKLKEIREHGGAGKPVIISEIGAGGIYGYHDPLGESKWSEERQCTILRDQVEAVLANPACSGVFLWQFADCRVTEEWAMHRPKTHNNKGVVDEYRRPKMSYAAVKELFTRHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5B8</accession>
    <name>R7I5B8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimM</name>
        <name evidence="6" type="ORF">BN770_01033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46815">
        <property type="protein sequence ID" value="CDE46815"/>
        <property type="gene ID" value="BN770_01033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="5">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="173" mass="19295" checksum="8914D5AD5E45C756" modified="2013-07-24" version="1">MNEYLMIGEVLKPQGVRGEVKIKPYAADLEAFHDWKTLYLLDGTVYQPIKAVCSRVHDGFAYVTLGDCKTMDDAEKLRGQKLYIDRAHALSLAEDEVYISDLIGCAAVDETGASLGKLTDVLQHGAVDVYVFQSDKGEWMAPALKAVFPAVDVQNRIIRVVREKLDEVVVYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5J2</accession>
    <name>R7I5J2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46533">
        <property type="protein sequence ID" value="CDE46533"/>
        <property type="gene ID" value="BN770_00927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="112" mass="11953" checksum="63FCB87AC9C42B19" modified="2013-07-24" version="1">MLDLGENLRKLILAGVGVAAVTKEKGADVLNELVKKGELTIEQGKVLNEELKHNIKDAIRENVTIVTPPDDVISAVDSLSDEQLEALKAHIAAREATKKTAASAASDEPNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5S7</accession>
    <name>R7I5S7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46831">
        <property type="protein sequence ID" value="CDE46831"/>
        <property type="gene ID" value="BN770_01040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436194" evidence="1">
        <location>
            <begin position="21"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="446" mass="50040" checksum="234EE28E06945AB8" modified="2013-07-24" version="1">MRKVLAVFLALLMLCAGASAESLPPKLLPESYFLTDIQRNYPDWSVRVSTRYGSGRYEGEMAQYAEVSLYRITDEAIELLELTALVNPIREGDDVPWSVHALIPVEIVPGAADTLRAMTSKEIFDYGVGAAFTEAARNLLVPSLRAADETVTQLMSCSRFLFCITENSAEKYILRIAQWDGVGYTNVTATLPQPDLSFNTSHSYNDLMELWVNRDDWVYPRYDAEVGWHINHFFINDSNLVVFQNRIIEGEIEEWYQDNNSEHYGRFILPHSLTEVDFATFPQTLDEILSYMDYAGVACTAHDGTPLYAAPDGDVLAHCYTRVPMVVISESGDWREVQLGSDVDGLRCWVRAADLAFGADTENVVCTFPTHEEVDRAQEAVSFSGKALPLAKGCAWWMIGTMADGDYLMMFADNEEIFVGTAPASAFSEIGEAEDDDDWDDEDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Y5</accession>
    <name>R7I5Y5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46663">
        <property type="protein sequence ID" value="CDE46663"/>
        <property type="gene ID" value="BN770_00977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="422" mass="46505" checksum="F695D389F2255532" modified="2013-07-24" version="1">MSNDLFAGIGVVPGTFLLPRPDADWTAWACVACDQYTSEPEYWQRVNTLVGHQPSTLRLILPECDLPAPPERIDAIHAAMRDALNVLHPGVTDGFVLLERTTSTGKRLGLVCCVDLEQYRYDGAKTLIRPTEETVASRLPARLAVRNGAPLESSHVMLLLDDPQRTVIEPLYARRDQLSPLYDFDLMQQSGHARGWAVTSDADKAAIAAALNRLKDALGADPLLFAVGDGNHSLATAKKYYEQLKATLPAKEAAVHPARYAMVELVNIHDDALIFEPVHRVLTNVHPADVLADWSAYCAAHGMALSFVPPDADAQELRVVSASGEQTAFIAHPDGALPVATLQRYLDDFLRRHPEAAIDYIHGDEVLRRLSRADGAMGFLLPALNKADFFPAIEQLGILPRKTFSMGHAHDKRFYIECRKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7I689</accession>
    <name>R7I689_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="9 10">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">miaB</name>
        <name evidence="14" type="ORF">BN770_01226</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="9 10"/>
    <dbReference type="EMBL" id="CBJB010000044">
        <property type="protein sequence ID" value="CDE47374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47374">
        <property type="protein sequence ID" value="CDE47374"/>
        <property type="gene ID" value="BN770_01226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="12">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="172"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="11">
        <location>
            <begin position="404"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE47374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="466" mass="52665" checksum="020D48C8DB3BD202" modified="2013-07-24" version="1">MSDRKPVIISEEQLEEQRQYIQQIRLMPDAPKSYHVVTYGCQMNAHDSEILAGMLRDMGMEEAADRESADFVLFNTCCVRDNAERRALGNVTWLKEVRKKNPRLMIGVCGCMIQQPGMAEKILKQYRFVDLAFGTANLYRLPELMLKALESDQAVVEVEEQNTIAEGLPVQRLRHDAAYITIMYGCDNYCTYCIVPYVRGRERSREMSAIVAEAEALRDSGVKEIMLLGQNVNSYGKGLQTPVTFAQLLKALDDVGIPRIRFMTSHPKDLSDELIDVMAHSKHILPQFHLPVQHGNDEILRRMNRHYNRAQYLDRVRKLREAIPAIGLTTDIIVGFPGETEEQFQDTLSLVREVGYDSAFTFIYSPRTGTGAAKMPNQVPEDVSSRRIQELLKVQEECQKKALKRFIGTEEEVLVEGLSRRSDTDVSGHGLHGLSVTFPGTESDVGEIVRVKIVGAKNNTLTGERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6A3</accession>
    <name>R7I6A3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000038">
        <property type="protein sequence ID" value="CDE47180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47180">
        <property type="protein sequence ID" value="CDE47180"/>
        <property type="gene ID" value="BN770_01169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="301"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="528" mass="58359" checksum="F24619C67D693BAC" modified="2013-07-24" version="1">MDSNKKYFFAPVLMSDGSILYCNIGDKTAIVPDLEPDEPAWTQYKALSSLYVRTFPNAWCDTGVLKTLSKDTILELDVSHKLRDPRFGNDWAYARYKQSDGTYLYGWVIAANSYVEQVKQTPAWYDYFANPGSTVYVYKTQNVDDTIVKTYTSGGNFRVDVNNMRQDQNGYLWAPVADDTGKELGYTDLSAAHAGSKSAAIPLVYCKSGWALAYVLAEDGMDVLAAPNDAAALVKHMDRDADFWFGVNETYTDAKGKIWTRIYAAEDYEEMADGGWVRLENGVNYNTVYAQWYDTGCSISRNGITYTLYGGYNSWSSAQEMCANMGGDGGTAVRKHLAIVHNDAEQKIIEQLLNATSTVDKAWIGASNTSGSWQWVDGTNVQYSQWGYNEPSGTGTELGVVASFDGSWYAHDDYLDIHVQGFITEQFTGIGLPQVKLPASTFYVDDEAFVGNSTIQSVVAPDGLQVIGTRAFADCANLKCITLPDSVSYIAEDAFENTPDVVIFASVGSYAWQWAEKQGIPHGTPYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6G2</accession>
    <name>R7I6G2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47076">
        <property type="protein sequence ID" value="CDE47076"/>
        <property type="gene ID" value="BN770_01132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="273" mass="30168" checksum="C62913630F8851CD" modified="2013-07-24" version="1">MGTAWIIASGKGGVGKSTLSACLGMEIARNGQRVCIVDADIGLRDQDVLLGVQDCIVYDILDVANGICPVDDALVVPKPDALPNLSLLPASQFARAKELEAKAFRKILRTLKSNFDHVLIDAPAGIERSLRGLLSNEINECVLVCTPDDVCIRNAERTASVLRKKGLTAQRVIVNRLNPDYIRRGEMYAAQTVALTLDMPLLGEIPEDAEIYRALLHHQSVMEGESEGRNAIARIALRMTTDEDVPLPEYGQKRTLFQRLFQRRKKGDEKHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6M9</accession>
    <name>R7I6M9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mini-ribonuclease 3</fullName>
            <shortName evidence="2">Mini-3</shortName>
            <shortName evidence="2">Mini-RNase 3</shortName>
            <ecNumber evidence="2">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mini-RNase III</fullName>
            <shortName evidence="2">Mini-III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mrnC</name>
        <name evidence="4" type="ORF">BN770_00773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MrnC RNase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46192">
        <property type="protein sequence ID" value="CDE46192"/>
        <property type="gene ID" value="BN770_00773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01468">
        <property type="entry name" value="RNase_Mini_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008226">
        <property type="entry name" value="Mini3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005520">
        <property type="entry name" value="UCP005520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="34"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="153" mass="17239" checksum="FE90088882147719" modified="2013-07-24" version="1">MPVFFGHMKEEMPLTLREEAPMTKDDARRLNPLQLAYIGDTVYDLLTRSRLLYRGYNLHHCHQAAVTVVNAHAQAEALTRIEGALTEEENAIVRRGRNTHAHHAAPRNQTAMDYQAATALEALVGYLYLTGQEARLLELFRKSQEVASCPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Q9</accession>
    <name>R7I6Q9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000037">
        <property type="protein sequence ID" value="CDE47166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47166">
        <property type="protein sequence ID" value="CDE47166"/>
        <property type="gene ID" value="BN770_01162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="203"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="446" mass="48332" checksum="165433CDD79DB45B" modified="2013-07-24" version="1">MANYCQRVLDDLKVRYAHEPEFIQAATEILTTLKPVIERNEEKYEAAGLLERFVEPERIITFRVPWMDDQGKVQVNRGYRVQFNSAIGPYKGGLRLHPSVNQSILKFLGFEQILKNSLTGLPIGGGKGGSDFDPKGKSDNEVQRFCQSFMTELYRYIGKDTDVPAGDIGVGAREIGYLYGQYKRITGLYEGVLTGKGLTWGGSLARKEATGYGLCYFTQAMMERNGKAIAGKTVVVSGSGNVAIYAVQKITEMGAKVVAMSDSNGYIYDPDGIKLDVVKQLKEVERKRIKEYVKAVPTATYTEGCSGIWTIPCQIALPCATQNEINEASAKALIANGVEAVGEGANMPSTLEATAAFQQAGVLFAPAKAANAGGVAVSALEMSQNSQRLSWTFEEVDAKLKDIMVNIFAKVDLAAHEYAKEGDYVAGANIAGFLKVADAMMAQGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I730</accession>
    <name>R7I730_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47088">
        <property type="protein sequence ID" value="CDE47088"/>
        <property type="gene ID" value="BN770_01144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="96" mass="10581" checksum="AA0C866FD68AAE79" modified="2013-07-24" version="1">MNSKQRAMLRGMANTMETILYIGKDGVVPGTIKQASDALEARELIKCAVQQGCPLTAREAVTELCAALEAEPVQCIGRRFVMYRPSKDNPRIVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I756</accession>
    <name>R7I756_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000033">
        <property type="protein sequence ID" value="CDE47113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47113">
        <property type="protein sequence ID" value="CDE47113"/>
        <property type="gene ID" value="BN770_01150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17766" checksum="6396BCECC06A429A" modified="2013-07-24" version="1">MPKVWTDDTALMEGMTDNLFEALYKMPKYFLRIGDIAHSLGMPISSLLVLCVLREGKISIGEISERLCIAKPNVTPLVETLCARGLISRQRSDKDRRKVLVGLMPEGEAMVERIRGAIRDQMMSWPRNYNLSEMKRVNNALAATLEVADDVMRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7E0</accession>
    <name>R7I7E0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47744">
        <property type="protein sequence ID" value="CDE47744"/>
        <property type="gene ID" value="BN770_01331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="649"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="767" mass="86275" checksum="AD255AF654252CA3" modified="2013-07-24" version="1">MTAKRNRHKQSVQPKVIEIATRKYLAIAIVITFLLSVILTVIQIVSLSGYTSHLADTGARQLEQRLELALQNIQSNASMLRVSRETAKLSQTVSFTEEALRSINYMETLNTIKLTDDALYDIWVLNEDRGVVYTASRTRYSADVPAIRNIVEETAQEAWDEGFAIAQVDGYPGQEISRSCLIYRQRLDVSDVGFHGAVYLLLDCKKLYASLLEHNDSLEELMVLTHDGRTVCSQPMNSQPVGARVEAAIDFLASPNETYQHWVDGGKICSAYRGRHFLYVVWVSGDIVIMTVVQQALYALIVLAVFIMVIVISFRMIARQMNRPIAELQATLERQLQEQSIPTDTAREATNVLTQVSEQWHASDGQETIQQMDLQLYEAVTSNKLTESMLVHLASFDHYVFLLCDIDEPHQHIVEARKLSPFLDYLLRYSLRGILGEGESSYTVRINEWSIAAAVSFQNSPSEQARQALMDKSSALMQAFTTCTLSFSCSSVFSGREHVAEALNEAKRAIRWKLVRGVGCTILYTPGMGVSRSFTFPQAKIQSIVSSIDRGENAIHERLRELLAKLLESDAGMDDLEFAVSQLLGVLIQTAFRKGVQFNALFDEPEHSPFRYLSSFDTLEHMLTWLEGKFVQLSRQLAKAHKGGSGYTNKFIRYIGDHYAESLTPEDVASALGISYSYLRKIISTEMGTTFSAYLLGIRLEKMKELLVNTTISQRDIAEQVGIGSEQTMYRLFKQYMGCSPGEYRKHPSADSTIAAETADEYHESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7F6</accession>
    <name>R7I7F6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47764">
        <property type="protein sequence ID" value="CDE47764"/>
        <property type="gene ID" value="BN770_01346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="334"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="447" mass="51151" checksum="4AB5FA69EE410432" modified="2013-07-24" version="1">MTERMSTFFPSEFTGIAQWIICTIYILSNEKGIRGWKAVALILFALPILVLMNIAHSEQPALVWLVITVCCLASVLIYLRLGIREDFSLILLRWCNAVMQSEFAAALAYAINIYLVSRGVMRFPDIRASQTIMLFVYVIIFIPLGISIYHRSHRKNRPLKAGYVEVISSFMITIGAYLLSNISFLAPESIFGISMGGGILLVRVVSDFSGMLALIAIDEFSYGMRLKMNMGVLQSLLDRQYEQYQQFKVNNEQMQQVYHDIKHLINYIRSVSVSQKYEKELRSVEQTVSNFETQYDTGNPVLDVVLSSKKMMCRSALITMECYMDAREMDFLDTAQICTIFGNALDNAIEYESRIKETEKRLIKVSVFSENHFLVIKISNYCEETILKSLEDPETTKENPEIHGYGIKGIRLAVEKYEGHMTIKQENNWFIVSILIPIPEKQNQTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7K4</accession>
    <name>R7I7K4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000040">
        <property type="protein sequence ID" value="CDE47238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47238">
        <property type="protein sequence ID" value="CDE47238"/>
        <property type="gene ID" value="BN770_01176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="131" mass="14073" checksum="C34B3705C62A5CEC" modified="2013-07-24" version="1">MTYADIAGLTQEQAARVACGLGGGIGRLRDNCGAFSSAVMLCAALEGADGAKPEHRPQTYARVQRVYRAFIARNGSICCAELLGREKKPESPTPDARTNAYYSSRPCAKIIRMTCKIIDEMLAENAAGQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7U5</accession>
    <name>R7I7U5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage V sporulation protein AA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000057">
        <property type="protein sequence ID" value="CDE47685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47685">
        <property type="protein sequence ID" value="CDE47685"/>
        <property type="gene ID" value="BN770_00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="185" mass="20015" checksum="FEE910A1CC08C19C" modified="2013-07-24" version="1">MIYVQLRARVKLAQGETLHVADAAKVLGSEKAGHCSLFCPTAPGVYTLDAIAVAKALKKVFPQEDISLIGAEVCYVHRIKARGKDFLRPVRTAAALLILLLGSALGLTWFHADVNMPQAQADVYAAITGAPPDDVRLITIPYCVGVALGVCVFYAIPFPHQTTPLEVKLTEYQEDMEKAEGKPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I875</accession>
    <name>R7I875_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative membrane-associated zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46707">
        <property type="protein sequence ID" value="CDE46707"/>
        <property type="gene ID" value="BN770_01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="122"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="355" mass="37923" checksum="147204BF09F294C4" modified="2013-07-24" version="1">MTVVSVLVALLLLGILITVHEFGHYIFARMTGIEVMEFAIGFGPKIVGWTGKSGTKFALRCIPLGGYCAFYGEDDVEGKATNDPRAFGKQPVWKRMLSVLMGPGMNFLLPLVVLVLYFWIGGVTGTEALVADVEQGGPAYTAGLQAGDIILDVNGTAPNPENASQSLTELINATLGDTMVLGIRRDGERTEITLTPFYDAETGRYRMGIHVSAAASGEMLPVSFGEAVRDSWNVCVNAATIIGKALRDMVTTGAGLNEVGGVVGTVAAVSEQVNTYGFAAFINALVVISINLGIMNLLPIPGLDGARFLFLLVEAIRRKPLPQKKEAIVNLIGMALLFGLMILLVFKDVWTLMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I899</accession>
    <name>R7I899_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaK</name>
        <name evidence="13" type="ORF">BN770_00113</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="9">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48104">
        <property type="protein sequence ID" value="CDE48104"/>
        <property type="gene ID" value="BN770_00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE48104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="606" mass="65479" checksum="A4EC8C763996543D" modified="2013-07-24" version="1">MSKIIGIDLGTTNSCVAVMEGGQPVVIPNAEGARTTPSVVAFSKDGERMVGQIAKRQAVTNPDRTVISIKREMGTNYKVNIDGKAYTPQDISAMILTKMKETAEAYLGEKVTQAVITVPAYFNDAQRQATKDAGRIAGLEVLRIINEPTAASLAYGLEKDGNQKILVYDLGGGTFDVSILDIGDGVFEVLATNGNTRLGGDDFDQRIIDYVADQFQKENGIDLRKDRAASQRLKQEAEKAKIDLSGTTSANINLPFITADANGPKHLDVTITRAKFEELTADLVQATITPMEKALKDAGLTYNDISKIILVGGSTRIPAVQAAVKRVTGKEPFKGINPDECVAIGAAIQGGVLGGEVKDVLLLDVTPLSLGLETEGHIFTRLIDRNTTIPTSKSQVFSTAADGQTTVEINVLQGERQMAYDNKSLGRFQLTGIAPAPRGVPQIEVTFSIDANGIVNVSAKDKATGNEQKITITASSNLTEEEINQRVKEAEQYAEQDKKRKEEVETLNHADSMIYEMEKQLRENGDKLSAEDKATVESEIANFKKVREGNNAEEIKNAMDAFTQKVYAIFGKLYQQQGGEQGANPEQPQAGTQNADGTYEADGDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8K1</accession>
    <name>R7I8K1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47811">
        <property type="protein sequence ID" value="CDE47811"/>
        <property type="gene ID" value="BN770_01372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="237" mass="26994" checksum="CA9C58AFED51AA98" modified="2013-07-24" version="1">MMRLQKFLALSGVASRRNSEKLIADGHVAVNGKVITEMGVQVDESADVVTVDGKVCKIQEEKHYLAYNKPMGEVTTVADPEGRPTVMDKFRDYPVRLYPVGRLDYDSEGLLLLTNDGDLMNNLLHPSREVSKEYLVKVSNRVTDEEIRRLRAGVRLDDDRMTSPADVHLVRYETFASVLLVTIHEGRNRQVRRMFSAIGHEVVALKRVGFATIKLHDLPRGQWRRLTDVEVRKLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8L8</accession>
    <name>R7I8L8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47955">
        <property type="protein sequence ID" value="CDE47955"/>
        <property type="gene ID" value="BN770_01455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="8">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="202" mass="23571" checksum="4FFD6FBEA276BFAA" modified="2013-07-24" version="1">MIDDLFCEFGGGERVDENQVGQNERLTPTNMRTNVPLSDEQILEKQRKRFRGTYNHSLDGKGRLVIPLAFRQELGERFVIAPEFDFKSIAIYPEMVFMRLCEHYERLNRKKKNAQLMNYMQWFNSMSYTDQECDAQGRVLLPAKLRSMMLGEEKDVDIMGNDDHLRVAATINNMANFELFKDNLNATWAAIDELEDGEDEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8N4</accession>
    <name>R7I8N4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000055">
        <property type="protein sequence ID" value="CDE47643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47643">
        <property type="protein sequence ID" value="CDE47643"/>
        <property type="gene ID" value="BN770_01322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="33" mass="3955" checksum="FD8AC924F58018A9" modified="2013-07-24" version="1">MKRRSQGMLRKGFGNQTFFEGLMEEYGFNTFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8R5</accession>
    <name>R7I8R5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative stage II sporulation protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48005">
        <property type="protein sequence ID" value="CDE48005"/>
        <property type="gene ID" value="BN770_01487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447669" evidence="2">
        <location>
            <begin position="28"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="4">
        <location>
            <begin position="130"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="540"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="604" mass="65229" checksum="7BA82F3DE59FCDB9" modified="2013-07-24" version="1">MKRLLRAVCLALCWTLLMAGMPGRASAEEAAPMVRVLLRRLQLTDRADLTLAGAYTVRVGGEDLMALPENAQVTVQIRSGALYLFYDGMSMRLGKSAEFRRNQSSSAMPGLRFEKNGNLYPGSLMLTVENGTLVPILSLSVEDYLLGVVPYEMSDSFPLEALKAQAVCARTYALSHLNASRAYDVVDTTNDQVFKGVDSSTKNAARAVQETAGIVGMYNGKLAECFYSASNGGQTELVENVWSGSGDYGYYAMVDDPYDLENPQSIVRTMKISKNGALKEALRTLIYEQMLPVLTREGYSTGQENFRIDEITAVTLASPAFAAPSRRMTELVVALKWSGKKPFASILPEETAIPLPAGDATYDVAPAEGDEWELGEATATPSPVPTATATSVPTPSPTPDNRLTDFLSAGEATVTISLNRQNTAALSLDISGSEIFSVTEENGQFLLQSRRYGHGVGMSQRGAQWMAGQYSKKFDEILAFYYPGMVLMQGGTGAPVLPTVPPELAATPAPPATPTPKPTLMPVTTDSLPEGAKVMYVNASSLNLRAEPSMVGELLMRLQANQRVIVLEVCDDPEWVHVKTDVVEGYCMVSYLAEEGVKPTPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8T2</accession>
    <name>R7I8T2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47906">
        <property type="protein sequence ID" value="CDE47906"/>
        <property type="gene ID" value="BN770_01422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="264" mass="28062" checksum="9D51F837D04E11EC" modified="2013-07-24" version="1">MSNMFSLEGKIALVTGASYGIGFAIACAMSDAGATIVFNDIKQELVDKGIAAYAEKGIKAHGYVCDVTDEAAVNALVAKIEEEVGVIDILVNNAGIIKRIPMCEMTAEQFRQVIDVDLNAPFIVSKAVIPSMIKKGHGKIINICSMMSELGRETVSAYAAAKGGLKMLTRNICSEYGKYNIQCNGIGPGYIATPQTAPLREIQPDGSRHPFDKFIIAKTPAERWGDAADLGGPAVFLASDASNFVNGHILYVDGGILAYIGKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I923</accession>
    <name>R7I923_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48110">
        <property type="protein sequence ID" value="CDE48110"/>
        <property type="gene ID" value="BN770_00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="332" mass="37981" checksum="3F21031D0E52B957" modified="2013-07-24" version="1">MHYIVVDLEWNQPMSFDSSVFRQVGDRLVFEMIQIGAVKVDDKYQVVDSISIPIRPQYYVKIHPRIRKMTQLGAEELADAPTFLDAMAQFTAWCGEEYTLLTWGCDDISVWKQNMDFFGCTEPMPPICDIQRLFSDVNGCRDRKGLKVAMEMLGIEPDAARYFHNALHDAYYTALVFARLPQPEDVLKYPQKPRPLIHTDKRERAGGETFGTVNEAFASDFARVPRCPVCGKKMKLEDGAYVRQAADKYISIAKCPQHGNMLIRVRLRLESDGQKRLTMTAAKASPSNLAYVHTKRLQMTQRDAAYEEKYGKPVDLEAELEKADRTSMPFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9B9</accession>
    <name>R7I9B9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM receptor with intracellular metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47868">
        <property type="protein sequence ID" value="CDE47868"/>
        <property type="gene ID" value="BN770_01403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="HDc" evidence="3">
        <location>
            <begin position="504"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="815" mass="89150" checksum="AF6E2457CA826722" modified="2013-07-24" version="1">MRKRENKQNHRPILRRFTTWLHGAGAKCALIYAVGTLVLLVLFAAACAPQRYSLSVGAISHQTITATKDVEDTVTTESRRREAAARVEATYHFQEGVTESVLSDLDETFRQLRIVQQYGLTLRVQDGETATETNLAATFSGEEIDYALQQVEAVSLTRYQATVLMRASTENFDTMAVTVRLAVESALNTTIREGQVSQSIAAIKQIAGYRVETSLMQNIVPVVLNHCIRPNMVIDQELTAQAQENAAAQVEPVVYLQGQNIIREGERVQANQLAMLEALGLLDTASYDYDIYLGALLLIAISMSVLILMLVILAPEVLRDVRRSSVIMVVLVLCEGLCVIAVKLMDVYLAPVVMAAMLLTTLLSARVGISATFTMALIAAGLSAGSSNAYSAEMVHLILTGVVSGIVAVQYLKDKPQRVRMVIAGVIVAVVNMVVILAMSLMTSNNISGMMNNAMWSMAGGILSGLISVGFQPVFEAAFNLATPAKLLELANPNQPLLRRLLLEAPGTYHHAIVVANLAEAAAEKIGANPLLARTGAYFHDIGKLKRPLYFKENQMGDNPHDRTDPYVSAAIVTAHTRDGLALAQKYHLPPEIQTIIMEHHGDTPVMYFYHKALQMADGKPVDIADFRYDGQRPTTKESAIVMLADTIEAAVRSIPDPTPKAIEQFIERLVRGKLEDGQLSNSPLTLRDIDAICEAFCKVLNGVFHERIEYPTVNVPARPLVKAEKEAEKETKQMQAEIKAEKPAEVEKTPEVKPEAKAEKQAEAEKTPEVKAEAKAEKQAEVEKTPEVKAEAKAEKPDVPEKPAAPVEESEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9F1</accession>
    <name>R7I9F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000090">
        <property type="protein sequence ID" value="CDE48220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48220">
        <property type="protein sequence ID" value="CDE48220"/>
        <property type="gene ID" value="BN770_00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="45" mass="4741" checksum="AEAFB0B6B5C4A789" modified="2013-07-24" version="1">MKLLMEPMVVAAILMKELPDKQVGSAESAKDASAAPEVPARDTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9H7</accession>
    <name>R7I9H7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48146">
        <property type="protein sequence ID" value="CDE48146"/>
        <property type="gene ID" value="BN770_01559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="349" mass="41147" checksum="56ADF48AE9578FFA" modified="2013-07-24" version="1">MNQVSIIIPVHNTPEEYLRECLHSVLRQDYTNWEAILIDDGSTSGAERICDEYAAKDARFCVIHQRQSGVSAARNAGMAAANGDWLIFLDSDDWWEDNLLSSAMKKLAEEPADLLVFNFKTFSQQKTDETAPPAEKKRHVGTSIMEEMQLGLLDRNERYAANYFGGPCIQLIRRTIVVEHQLAFPEAIHQSEDALFNMQMLEYVKSVDFLHETLTTYRVWGMSSFQRFHADLPQQMEQVNQQFLTFGKVHHKGDFYWNAYEVWLMETYIRLLKRYFYHPNNPQSEAEKKRAWKALLTTCPSLKQLRRASWKKMYQSRKSYPLLLFFLLYCRCYALNRRVMEWLLRTDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9I9</accession>
    <name>R7I9I9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="3">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murE</name>
        <name evidence="7" type="ORF">BN770_01458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="3">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47958">
        <property type="protein sequence ID" value="CDE47958"/>
        <property type="gene ID" value="BN770_01458"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="3 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="108"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="328"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="3">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="3">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="3">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="110"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="487" mass="54134" checksum="2008B1637BC2CF9E" modified="2013-07-24" version="1">MELRQLVKEVPYLLETRGDMSVEIAALCSNSREKTENGIFFCFAGAHFDAHQYAPQAVQNGCVALVVERFLDDVNVPQVLVSNGRAAMARICEAFFNHPERKMRFVGITGTKGKTTTSYMVKSICEQAGFKCGLVGTTGNMIGEKHIPSSKTTPDPIDLMRDLNEMVQAGVQVVVMEVSAHALDMHRLDGMTFECGCYTNLSQDHLDYFGTMENYFQCKKAFFTSGMAKNAAINADDERAAELLRDVTIPHMTYGIAAEADLFARDIEITENGVSFELRLRNAEYIQINLRMTGMFNVYNALSAAACALILGVSPENVRAGLESIRSVPGRIEMLPTNTPYRVILDYAHAPDALSNILRTCRTFTKKRLIALFGCGGDRDKGKRPIMGRIGGELADLCILTSDNPRTEDPMEILREIEEGIKETTGEYVVIENRRDAIRHALEIGREGDIIVLCGKGHETYQETMGVKRPFDEKVVVQELLTELRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9M7</accession>
    <name>R7I9M7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplJ</name>
        <name evidence="6" type="ORF">BN770_01615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48280">
        <property type="protein sequence ID" value="CDE48280"/>
        <property type="gene ID" value="BN770_01615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="170" mass="18495" checksum="1F94F9F5C39B3075" modified="2013-07-24" version="1">MSKVHEVKPEKVAAVADIVEKLKNAQSVVICSYSGLTVEQVTEIRKQCRENDAAYCVLKNRLVLRALNEVGITGLDDLLNGPNAFVFSMKDAVSGPKIINDYIEKNKLESLKITGGVLGTETLDVAAVKHLATLPSREVLLAKLLGCMTNTVASFVRVVDAIRKQKNGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9X3</accession>
    <name>R7I9X3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000042">
        <property type="protein sequence ID" value="CDE47307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47307">
        <property type="protein sequence ID" value="CDE47307"/>
        <property type="gene ID" value="BN770_01207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="191" mass="20179" checksum="AFD767D2915A0380" modified="2013-07-24" version="1">MQQESKAHRLWTLFSSMLLISTFTFGGGFVIVSLMKKKFVDELHYLTEEEMLDMTALAQTAPGAIAVNGAILVGRRIAGIPGLIVAVLATILPPIVIISIISMMYAAFAENEWVRAVLTGMQSGVAAVICDVTANLGGKVVQSKDWLNLLLMAGAFVASAVFHVNVIVVILVAAAIGVIRALLARKGGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA07</accession>
    <name>R7IA07_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent Clp protease regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000093">
        <property type="protein sequence ID" value="CDE48296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48296">
        <property type="protein sequence ID" value="CDE48296"/>
        <property type="gene ID" value="BN770_01627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="343"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="3">
        <location>
            <begin position="525"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="629" mass="70163" checksum="867E5F3B37E18025" modified="2013-07-24" version="1">MENLIPRWYRELELFRGVKPLLVLEGCVMDQVRVPVTGSVAEDTLLPLSAFLNAYLSDAGYEQVVFYSNLVGLMNPYAPEMLDNFAKTNQAEVVSGAIPAEFKGNDANTAPNIIRRAMMQGKHATAVVMEMASRYIVTPDRLDQMEVNSFNLLLQASLSAATVRTAQGKLPNLLILLVNKLNDLPAWFYLDNPVCKTITLEAPDRDERMRFLSGSAWPSFFDAAVYRTDMPYYQQHSDDLRKLREKFVGLTEGMSFTELDALRRMSRSQCAPIRDLCSIVDLYKYGIHENPWAKLSMESLKTAKTDFQKRIKGQDTALERSLDVIKRAVTGLNGANSSGTGKPKGVLFFAGPTGTGKTETAKALAEKIFGDESACVRFDMSEYGQSHSDQKLLGAPPGYVGYEAGGQLTNAVKKNPFCILLFDEIEKAHPSIFDKFLQILEDGRLTDGQGHTVYFSETIIIFTSNLGMYVKDALGQRHQNVSYDMPYDEVTRRLREAIGDYFKLELGRPEILNRIGENIVIFDFIRQEAGQAILRAQVDKLIRRLKEQKNLTLVIPDESYQQLSDAALADLTNGGRGIGNQVEALLINPLSRYLFDSGIIENATVTVDAFETAAQPPALRCTTTKEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAG9</accession>
    <name>R7IAG9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VRR-NUC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000051">
        <property type="protein sequence ID" value="CDE47517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47517">
        <property type="protein sequence ID" value="CDE47517"/>
        <property type="gene ID" value="BN770_01273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10412" checksum="E8F1B1A38A7051FA" modified="2013-07-24" version="1">MRERDIEKRLVDAVRKRRGLCPKWVSPGLAGVPDRIILMPGGHVAFAELKAPGKKPRPLQLTRKAQLERLGFRVFIIDNTEQIGGMLDEVSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAP3</accession>
    <name>R7IAP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000113">
        <property type="protein sequence ID" value="CDE48566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48566">
        <property type="protein sequence ID" value="CDE48566"/>
        <property type="gene ID" value="BN770_00144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435647" evidence="1">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="252" mass="27814" checksum="EFAEDF7016B3F894" modified="2013-07-24" version="1">MKRIIALLLAALLMVSCALADVALRGYDAKSGYVYITLGQCPQDADGGVEPIVWRVLNVEDGRAYLLSEYVLEARPIHSDYQEYANKPTNKKKPGFNGDFTQTEMSRYLCGDFAQNCFTDDERAMLTPDDTFGLFFLASDADLKNKAYGFTSNESRKAWGTPYALANGLFKYGSQRGGHSPYWTRSQSSSDARHARCIKSKGELGRINVITLDEGMRPACYLSLSASEISGGTGTLDDPYTFTLIPPTVMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAQ8</accession>
    <name>R7IAQ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47592">
        <property type="protein sequence ID" value="CDE47592"/>
        <property type="gene ID" value="BN770_01303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="229" mass="25642" checksum="845FF509FAA32341" modified="2013-07-24" version="1">MIFVVEDDHGVRELELYALRQSGYEAEGYETPTAFRQALEKTVPDCVLLDVMLPGEDGLSLLRFLRRDARTRRVPVILVTARDAEMDKVKGLDCGADDYLTKPFGVMELLARVRALLRRTQEETPSAVMTLGDVTLDRESHRVTAGGQEIALTHMEFELLAFLMAHAGKAVTREVLLDDVWGIAYSGDTRTIDVHVRTLRQKLGDSGRLIATIRNVGYRMDEHPEAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAR7</accession>
    <name>R7IAR7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cellulase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48670">
        <property type="protein sequence ID" value="CDE48670"/>
        <property type="gene ID" value="BN770_01780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="336" mass="35756" checksum="4DA3C452101C2744" modified="2013-07-24" version="1">MDLKTLTEINAPSGHEQAIRRVLLDELKKLGFAPVLDRMGNVVVVKDGTGDAPRKRVMVSAHMDEVGLIVTSATEDGYLRIAAAGGIDPRVLVSKRVTVGDDKLPGVIGAVPIHLQSAAERKHVLSMDELLVDIGAKNKDEAERKAPMGTYISFDTPYVEYGDGFACGKAFDDRVGCLSLLRLLQEELPVDLVACFVSEDEVGCRGAKGAAFQQEPDVGIVLEGTTCNDLGDVPETAHVCEAGHGVAVSFMDGASIANRALFRKALDVAKQENIPHQVKHSVSGGNDGGAIQRAREGVPVVVLSVPCRYIHSPSSVVKLSDVESQFALVKALVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAT8</accession>
    <name>R7IAT8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49014">
        <property type="protein sequence ID" value="CDE49014"/>
        <property type="gene ID" value="BN770_01890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448124" description="YkuD domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="408"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="654" mass="71378" checksum="257D069A5B33E979" modified="2013-07-24" version="1">MRKMLCLLLMLAMLTPCLPALAEDTDALDVILLSSASIEPLQETLRPGKAVTLRFTSPVDGTVTLLLRNAETLETVLPVAKDYPVTAGENQMLWNGTYEGVFAPEGIYRLVAQFSDGSEADTAILVGQIAPFLTSISALESTEDGEVHLSFYASENGRLTLGLWGASWSLLENIDISAGTNEVTVDATALSPDTVAISLTLTDNTGYCSNEEHVAVNPASFGILPTATPTAEPSPTPTASPTPTPSPTPTPSPTPTAVPTPSPTPSPSPTPSPTPTPNITFTPSYGSPYEFPSDAPASYWNTPMDYTDEAAVWAMLTAPMTVVKGDGRTQVRIRKEPDSKSAAIGILTRATQGIRVIETLDNGWSLIECYSSSFADNTVKAWNLLVQGYVETNTLTTVEWDSNDKYGLVVDKLTQRLYIYEDGHLISTLLVSTGLANAKQPFNETRSGEYIIGSFTGEFTSGNLYCGMGLRYNDGDLLHEVPHTKRADGSKSYAYNEPKLGTRASHGCIRVQRLRNTEGLNMKWLWDNRKHLGRLVIWEDWQGRQIPIPDDDTVLYYNPNGGSYYHRADTCYSVTKDNVTFESFTYAQLDEEPYSKLDFCPYCAPAMRKADIEAINAQYVFGGDHDPILTAARQPYFDYIASLDPPEATETPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB31</accession>
    <name>R7IB31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma-24 subunit ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48760">
        <property type="protein sequence ID" value="CDE48760"/>
        <property type="gene ID" value="BN770_01813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="170" mass="20091" checksum="23B285CDE314F8B9" modified="2013-07-24" version="1">MEQRSPNERRLEDWMRTYGTAILRTCFVILSDAREAEDAMQDTFLRAWRAMDTFEQRNGASVKTWLMRIAINVCRDYQRKRWFRHIDMRHALEDLPQGMMTVLPEDRELMLDILRLPDDLKKPLILYYYQDMNLQETADALGISKSTVHTRLKKAEQALKLSLTGGDCYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBB5</accession>
    <name>R7IBB5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49199">
        <property type="protein sequence ID" value="CDE49199"/>
        <property type="gene ID" value="BN770_01935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spo0A_C" evidence="2">
        <location>
            <begin position="118"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="232" mass="25913" checksum="523C198C114E5267" modified="2013-07-24" version="1">MQPRRFLLLADNPLTLAQLRAEIEDLGEETRCQTALTAEEALFRLSQESVDAVLLLPCPAADCLTQSLIRHPPLAPPFLLGGLDGELPEISQLPAWFSVLRLPALAAAHLPECTELAHQLLTALGMPRTLRAWAFLPEMAALTVVHPPLLTDVTHGLYPLMARRAQLTPCAVERRLRLAIESTWNRGDYDAIARFFGQSVDPERGKPTNREFLCQLQERLTLSARRMERRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBD6</accession>
    <name>R7IBD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HTH-type transcriptional regulator CymR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49214">
        <property type="protein sequence ID" value="CDE49214"/>
        <property type="gene ID" value="BN770_01940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="137" mass="15167" checksum="C7542C72D726A1CF" modified="2013-07-24" version="1">MKISTKGRYALRMLVDVAQHQSSGTVTLKEIAERQGISKKYLEQIALVLSQAGILRGARGHQGGYRLAIAPEKLSVAEIIRVMEGSLAPVACLDRHPNECERCNECQTLFVWEGLDRVIQSYLEGITLQDVLAHPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBE7</accession>
    <name>R7IBE7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48633">
        <property type="protein sequence ID" value="CDE48633"/>
        <property type="gene ID" value="BN770_01757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="9"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="393" mass="41568" checksum="C48EAEBC26A9C09D" modified="2013-07-24" version="1">MSRLTYRHTIAASYLGYITQAIVNNLAPLLFVTFMSEFSLTLEQITLMTTVNFAVQLLVDLLSAKLVDRIGYHVSIVAAHVLAVLGLSGMAILPGILPPMTGLMIAVVLYAIGGGMIEVLISPIVEACPTEGKSAAMSLLHSFYCWGHVALVLLSTLFFAAFGTANWRVLTLLWMIVPIANAVYFSFVPLYPIVPEEAQQMPMKRMLTSRVFWLLVVMMVCAGASEQAMSQWASTFAEDGLHITKTMGDLLGPCAFAITMGTARALYGKFADKLPLKTAMIASSILCIVCYIVASQSGNALAALLGCALCGFSVGIFWPGTFSLAALALPGAGTAMYALMALAGDLGCSAGPTTVGLFSGALGGLQSGLTVGMIFPIAMLVLCAFLKTEKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBI5</accession>
    <name>R7IBI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47867">
        <property type="protein sequence ID" value="CDE47867"/>
        <property type="gene ID" value="BN770_01402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="112"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="327" mass="36528" checksum="152E823D305F0230" modified="2013-07-24" version="1">MTETRKIPLTLDSMDAYMSLFGLNDQNVALVEQECGVAVSLRGSELFLTGEAEDAALAESVILKLLEMIRRGDLVDRTRIRYAIALAREGDVDRIDEILRSVVAITHRGKQIRCKTLGQQEYVQAIRDHDLTFAVGPAGTGKTYLAMALAVVALKNKEIERIVLTRPAVEAGEKLGFLPGDLTQKVDPYLRPLYDALYDFMGVDSYQKLLERGVVEVAPLAYMRGRTLSDSFIILDEAQNTTSEQMKMFLTRLGFHSKVVVTGDITQTDLPYGKKSGLAEAIEILKDIPEIGMVHLTHKDVVRHELVQTIVKAYDAYYHREAEGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC51</accession>
    <name>R7IC51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48082">
        <property type="protein sequence ID" value="CDE48082"/>
        <property type="gene ID" value="BN770_01532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="89" mass="9828" checksum="B2852E4BE3C3024E" modified="2013-07-24" version="1">MMAFIGSVFNMIGSFINMVFGAVASVFHFVFSVLGGLLGLVLHLGMLLLVVGLVALVITRRKNYKQAKADEPRVIHMDNGETFKSYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICB0</accession>
    <name>R7ICB0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rqc2 homolog RqcH</fullName>
            <shortName evidence="1">RqcH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rqcH</name>
        <name evidence="3" type="ORF">BN770_01867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48928">
        <property type="protein sequence ID" value="CDE48928"/>
        <property type="gene ID" value="BN770_01867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00844_B">
        <property type="entry name" value="RqcH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043682">
        <property type="entry name" value="RqcH_bacterial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="457"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="580" mass="65269" checksum="6E92859421C94825" modified="2013-07-24" version="1">MPMDGLTLGFATREMNAILPGGRIDRITQPEKDTIVLLVRAGAANHRLLLCASPNNARCHFTNLNFPNPLEPPMFCMLLRKQILSGRILSIQQMHGDRVIHVDIDTVNELGDHVLRRLVLEIMGRHSNLMLLDEDGRILEAARHVSADMSRVRQIQPGLPYLPPPAQDKIAPEDAEAENLLAKLEAQGNVPLQKALAASVSGLSNPAAKELAYRVLPAGSDRTDNLPETAARLAELLRRLPQMADPRVLEDEQGEPADIFPFPYLSRDLDRQKPYPTVSQALERYFGARDQQDRINQKSASMVKLLKGQIERCEKKLAQQEEDLSSAARMDEYRIMGEIINANLWQLKKGQTEATLPNFYDENGGSMTIPLDNQLTPVQNAQRYFKKYQKARTTREIAAEQKEKTLKELDYLEGTLLDVGKCIGESELEEIRQDLMRAGYIRKGVNRRQQKALPKSKPYHYRSTDGIDIYVGKNAAQNDRLTGDARPNETWLHAKDMPGSHVIIRQEGEIPRQTLLEAAILAAWYSKGQNSSGVPIDYTLRRYVKKPGGAAPGMVIYTNQRTLFMTVSESDVRKIQLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICQ9</accession>
    <name>R7ICQ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">BN770_01616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48282">
        <property type="protein sequence ID" value="CDE48282"/>
        <property type="gene ID" value="BN770_01616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="127" mass="13161" checksum="2AD2F7AB345B3ED0" modified="2013-07-24" version="1">MTHEEIIAAVESMTVLELADLVKAMEEKFGVSAAATAVVAGPAAGAAAPAAEEKTEFDVVLKSFDAAAKLKVLKLVREVCGLGLKEAKDFVEAVAAGPKTVKEGLSKEDADKLAAQFKEVGGECEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICT8</accession>
    <name>R7ICT8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage minor structural protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48332">
        <property type="protein sequence ID" value="CDE48332"/>
        <property type="gene ID" value="BN770_01656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010572">
        <property type="entry name" value="Prophage_Tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06605">
        <property type="entry name" value="Prophage_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prophage_tail" evidence="1">
        <location>
            <begin position="180"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="466" mass="52008" checksum="D58F74D83872CAE7" modified="2013-07-24" version="1">MNLPCLLDDKMKPRADLHPIRLTVDRSLQPLSMAEMVLPPEDAPVCVRDFVRLCDGFGDDEIYRVSSISEEPGLRRVVQLEHGMATLADDMLPALTYAENVQTILKRILSYQTRIRWRVGDIEADEALVISAIGQTQSIYAALTSLLDMLPPNLCWAFDQTKLPWKLHLRKLPEEISCEGRLTRNISTVRVTRDASRLCTRVFPYGCGQGLDRVTLTPLLGREYIDAADTKTWGIAARTFTSDQIMDADTLKRVAERYLERHSQPTATVQLQGIDLSRITGESLDTFRLGQRFRLALPEENTVLVERIVAMHIPDVFGQPGRVTLTLANRQPALSDEIADLLREVNASKLIGGKLTELTFRNRATGTYTAPISHPFTLDEYPSVLSCVMRMTADNGVYIQTIMVDGTEIPYSVWGKTQSLDALPYLRRTSTGAVDSGQHSLLMMPTNPGGFVTSVITLKVIEKMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID73</accession>
    <name>R7ID73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">YeeE/YedE family protein (DUF395)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000111">
        <property type="protein sequence ID" value="CDE48532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48532">
        <property type="protein sequence ID" value="CDE48532"/>
        <property type="gene ID" value="BN770_01725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="9">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="283" mass="30559" checksum="1007EC76350433E4" modified="2013-07-24" version="1">MRTLLIPASCGLLLGMSLSAARLISPDGLRDTLRFRPSHALKAALWALGTAIAAMALLCWLAVMDIDRIVPLPLHAGTLAGGMLFGVCAALCGFTPGTALTGIASRKPMRALCAALGCLAGAWLVQYVPTEAIRGLWEAPAGTLFRMTLTEPYWFGGGFLRQGCIGLALMLLGLLMPSGVRWTRQIPPEKPTESAEPETFVALLPGEEPMVVEIPPEDAEIDDELHHLPPEDEVEEIDGSPEEENPDEPTGILPDEENMETETLEIDDELHHLPPEDDVEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID94</accession>
    <name>R7ID94_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_02053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49620">
        <property type="protein sequence ID" value="CDE49620"/>
        <property type="gene ID" value="BN770_02053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="223" mass="25686" checksum="F4C0BC4B9DF6410C" modified="2013-07-24" version="1">MFKILIVEDDTELCQLFSHVLEKNGYHTRMVSNGQEALDALAEEYVDLIISDIMMPVMDGYELVRSLRKKSVMTPVLMITARDAFDDMRLGFLSGTDDYMVKPINVSEMVLRVGALLRRVQMMNEHRQVIGETVMECDSLTVTRGETSMILPQKEFMLLYKMAAYPGKIFTRQQLMDDIWGYDSDSDSHTVDVHIGRLRERFRDNPDFHIVTMRGVGYKVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDA2</accession>
    <name>R7IDA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_02057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49625">
        <property type="protein sequence ID" value="CDE49625"/>
        <property type="gene ID" value="BN770_02057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="75"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="292"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="678"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="778" mass="86159" checksum="CE204A381A677160" modified="2013-07-24" version="1">MVTQSSGKKYHGTLTKKLFRDMSRSAMQFLAMFLLCAMGTWCFSGLDANWRMLELSTETPIAQSNLADFWVKGSSFGKNDILKLRNLPGVKDVQARVTLEMDCPDLGDEVTLMVHGYDGDMRICTPIIRTGSELSASDTRGCLLEEQFAQAHNLSVGDTVKVSYGGVSLTFFVRGTILSGEYLVTAKNITPQPDIYGYMYVSAKAMAAFPFTEMLVKASSDADLTQVRAEIMNTCPTALIVDKDTHSGTLSARNFVSMFRSLSYLFPVLVFAVAAMIVVNTLTRMIENQRVQMGTLKALGYRDRQIRLHYLSYAIVPSVAGSLLGVLTGQISIPYILWPIVSTNVRYPARLHAPISGITWLIAVLSVVMCLLICLHTYNRAARETTASLLRPKPPKSGSRILLERIPRLWGRFSFNTKMIIRNIFRNKGRSFLSLVGILCCNMLIICSFGLQESINTFIDDYYTHTLRYDVRANLISGQASSLDHYRETLNAMKVDGIMEQSVSLRSETNLRSCLLTVMTDDQTSIALGDNATFLTLPRTGTAISRKLAGLMNVGLGDTVSICLPGDSDTISLTINALADTNIGQGLFMSKEAWEACRKSDFQVTTLLITAPTPACSHLLEEMDEVGTLLYPAKQLVEMSSIMDSTTAAFTILSVAALALAFIICYNMGLMNFSERVRDYATLKVLGYHQREIRRLMLRENNYISIIGVLLGIPPGFLITTIILKMCEYDSMVFPTHVTFPSVAGACAITYVFAFLIQLLLTRKVRSIDMVEALKSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDC6</accession>
    <name>R7IDC6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Galactose-1-phosphate uridylyltransferase</fullName>
            <shortName evidence="10">Gal-1-P uridylyltransferase</shortName>
            <ecNumber evidence="10">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galT</name>
        <name evidence="13" type="ORF">BN770_02071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49645">
        <property type="protein sequence ID" value="CDE49645"/>
        <property type="gene ID" value="BN770_02071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00571">
        <property type="entry name" value="GalP_UDP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000766">
        <property type="entry name" value="GalP_uridyl_Trfase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39191">
        <property type="entry name" value="PTHR39191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006005">
        <property type="entry name" value="GalT_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="11">
        <location>
            <begin position="64"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="12">
        <location>
            <begin position="252"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE49645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="511" mass="57056" checksum="52E802FCA014C0C5" modified="2013-07-24" version="1">MSWEENTTQAIENLLIYASAKGLIETVDMPYFRNLLLDAFQLDAPAGDIVPMADVPPTATALLRTLCDLAVEKGIIEDMTYARDLFSARLMGLLTPSPKEVRAHFQQCVAQNHPEQATDDFYQMCRACDYIKVDAIAQNVRYFADTPAGRLEITINLSKPEKDPKEIAKLKNAPSVGYPKCMLCVENPGYRGRSNFPARQNHRMVPLSLAGQTWYLQYSPYAYYPEHCIVLNSQHVPMRISRGTFDRLFDFVQQFPHYMLGSNADLPIVGGSILNHDHFQGGRYHFPMDDAKVRCQLKSSVPGVSAALLDWPMSTIQLSGTDEQTLIAEASRILDAWRGYSDEACSILAETDGTPHNTITPILRKEGEQYRLNLVLRNNRTSGEHPLGIFHPHAPLHHIKKENIGLIEVMGLFILPGRLKTELAALNGYLTGEKPLVRPAESDPCAKHYDWLTEVVARHGLVQTSAEAEAILRQEVALVCAQVLADAGVYKRDEAGLAGFQRFMKALGYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDU2</accession>
    <name>R7IDU2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49770">
        <property type="protein sequence ID" value="CDE49770"/>
        <property type="gene ID" value="BN770_02125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="3">
        <location>
            <begin position="186"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="4">
        <location>
            <begin position="274"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="504" mass="54560" checksum="F8FFBA7793B55F4F" modified="2013-07-24" version="1">MDWMKLKSGSDVRGVAVGENAPLTEHVAMCLGMAFARYVAKHVGKPVTQVTIAIGRDSRISGPALLHAAAEGVSKAGASVLDFGMCTTPAMYMCIITPGFQPDGSIMITASHHPYDKNGLKFFLAEGGVEGDVVEELLKTASTLEPEDTPLAGTIVKKPFLPTYKEQLADRIRRGLGTDVPKPLLGLHVVVDAGNGAGGFYAQLMEELGAWIEGSQFLEPDGMFPNHIPNPENEAAMASISAAVKRVGADLGVIFDTDCDRAAVVDADGREINRNRLIALISAILLDEKPGETIVTDSVTSSGLKKFINDWGGEHYRYKRGYRNVIDEAIRLNKEGISCPLAIETSGHAALRENHFLDDGMYLVTVLIVRAMKLKQEGKTLGSLIADLKEPVESREIRLNITADDFRDAGKVVIQRVLDYANAAENWHIAPDNREGVRISFDLDGGMDNGWFLLRLSVHDPVLPLNVESDVPGGVQQMLESLLKVLNDAEGIDLTPLKKAVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDZ9</accession>
    <name>R7IDZ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound O-acyl transferase MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_02081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49661">
        <property type="protein sequence ID" value="CDE49661"/>
        <property type="gene ID" value="BN770_02081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="489" mass="53847" checksum="C204285FF8D28D8C" modified="2013-07-24" version="1">MSVVSFEFLGFLAALAVVYYVLPMRVRKWALLAGSAAFWLLCGWQGAAYLTAETLLIWGCARLMGRFSERRGVCRALLVGGMVTVFGAMVLMKALAQLQALPDGLLVPIGLSYFTFQSVGYLVDVYRGKVTPEKNYAKVLLFAGFFPQMTQGPITTWKQLMPQLDSPHRLSPNGFVSGVFLMAWGFFKKLVIADRLMPAVSVLVATAQELPGWLVLATAAMYAIVLYADFSGGIDIIRGAAELLGIDLPENFRRPFFAASIADYWRRWHISLGVWFRTYLLYPLVASRAGIGLAKVGKRLFGAKAGRAMPGAAASMVVFLLIGVWHGFYWNAVLYGLWFGLLTAAGMLLDPQFRKIRKRVTAHRGGAALMKAFGWLRTMAAVLLAQFFACTTSPGMAFGMMGRIFTDFGAGMMRNFPLDVLDGTVAIAAVLLMLLVDILCEKQPDLRKKLAVSPLYVRWTLLMGLMFLTLIFGCYGAGFDRAAFLYAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE84</accession>
    <name>R7IE84_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49633">
        <property type="protein sequence ID" value="CDE49633"/>
        <property type="gene ID" value="BN770_02062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="294" mass="31319" checksum="86E0BC62E88D138D" modified="2013-07-24" version="1">MKFFIDILKGMVIGLANIIPGVSGGTMMVSMGIYDTLIYCITHLFKQFKKSLMTLLPFVVGMIAALAILSNVITWALMDEFASLPTNTLFIGLILGGLPAIFKQIKGSKKRDSILGGILFVLFFALVIFMATLKETQDTGAVISLSVLEVLKLTLMGCIASATMVIPGVSGSMMLMLMGYYYPVIGAIKNLINALVALDGGAILYNVGILLPFGVGVVIGIFAIAKLIEILLAKWKCITYGAILGLVVASPFAILMGLSLPGFNLVQVIVSVLTFILGFAAAWLLARKDEKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEF8</accession>
    <name>R7IEF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49796">
        <property type="protein sequence ID" value="CDE49796"/>
        <property type="gene ID" value="BN770_02144"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448204" evidence="3">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="32"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="4">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="220" mass="23870" checksum="BFEB334A61F3F018" modified="2013-07-24" version="1">MRRLLSLLMLLIVLIFPLFAGRVRSASTACAIHVDVEQKMLTLFCGSEIAARYPIATGARDTPTPLGVFRINRRFSGEMGGFGTCFLGLNVPWGDYGIHGTNRPESIGTNASHGCIRMRVADAEALYARVPNGTVVVIECGAYGELGGSLRTLKNGDRSSMVRAVQRKLRALGFYFGTPDGIFGSATQRAVDKARETFSLSANGLVDWALYQKLGLTLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEI5</accession>
    <name>R7IEI5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49831">
        <property type="protein sequence ID" value="CDE49831"/>
        <property type="gene ID" value="BN770_02154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="104" mass="11393" checksum="85D1F8F539AED7FF" modified="2013-07-24" version="1">MAKELMSSEFSSFVKQDKPVLVDFWATWCGPCRMLAPVVEEVSAAHADDVVVGKVDVDKCPELAQQFGVMSIPTLILFKDGQVVDTLVGYHPKAALEDLIKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEJ2</accession>
    <name>R7IEJ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glyQS</name>
        <name evidence="10" type="ORF">BN770_02256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50055">
        <property type="protein sequence ID" value="CDE50055"/>
        <property type="gene ID" value="BN770_02256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="150"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="217"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="326"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="212"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="330"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="459" mass="52796" checksum="A7FFE38F281CC46F" modified="2013-07-24" version="1">MADLTMDKLVALCKNRGLIFAGSELYGGLANTWDYGPLGVEFKNNVKKAWWQKFVQESKYNVGLDCAILMNREVWVASGHVGGFNDPLMDCKACKARYRADKLIEDFTGGAETGDGWTNAELEKYIAEHDIVCPKCGKKDFTGIRQFNLMFKTHAGVMETPENEIYLRPETAQGIFVNFANVMRSMRKKLPAGIAQIGKSFRNEITPGNFIFRVREFEQMELEFFCKPGEDLQWFDYWRSFCKQWLLSLGIKEDSLRLRDHEPEKLAFYSKATTDFEFLFPFGWGELWGIADRTDYDLTQHQNHSGKSLEYLDPVTNKRYIPYCIEPSLGVDRMVLAFLCNAYEEQELEGGDVRTVLHLHPALAPYKAAVLPLQKNKLGTLASEIHADLAKYFPVDYDETGSIGKRYRRQDEIGTPFTICVDFDTEATQSVTVRDRDTMLQERVALKDLRSYIEERMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEM9</accession>
    <name>R7IEM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49768">
        <property type="protein sequence ID" value="CDE49768"/>
        <property type="gene ID" value="BN770_02124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="160" mass="18018" checksum="34141305E4614661" modified="2013-07-24" version="1">MRRNKQALCQEECEQVLRRATSGVLSLISLDGFPYGVPLSYALVDGVIVFHGALEGQKIDCIRRDNRASFCVIDADDVIPEKYTTAYRSVIVKGRIAIVTDEKQKHDLCIALAKRFYPDESAAEVEYTQFASRLCLMVLTPEQITGKMGLELMQRKEQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEV9</accession>
    <name>R7IEV9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000153">
        <property type="protein sequence ID" value="CDE49858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49858">
        <property type="protein sequence ID" value="CDE49858"/>
        <property type="gene ID" value="BN770_02167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="166" mass="19147" checksum="97B19C06DE36BD31" modified="2013-07-24" version="1">MGSFINALFNFLLGWIRGTAQWLWNMVTSDSHGGLLGWAMRNWLPLVILLCIFGVVMDFLVYLIRWQPYRVWGNFWTRFLPKRARRTPTGHHLIYADGTMIEEEQVVQHKPKPAPKREGTAATRRKRVIPARRAHFGTTQTELTPPPLTIAQDKNQYHDNIPGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFJ6</accession>
    <name>R7IFJ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rsgA</name>
        <name evidence="7" type="ORF">BN770_02282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50108">
        <property type="protein sequence ID" value="CDE50108"/>
        <property type="gene ID" value="BN770_02282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ENGC_GTPASE" evidence="6">
        <location>
            <begin position="87"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="178"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="307" mass="34241" checksum="B2BC7FDEA9A379F4" modified="2013-07-24" version="1">MREPEMTQELQAELHQGVLVRFFGGFYVAADADGQEYTLRCPKKFRHQRLSPLVGDAVRFTPGQGEEEGWLVEILPRKTECIRPPVANVTLLLVSICPSPEPDLLLVDRLLARAKKQGMKTALIVGKCDLDGGKLLAQMQEEYRGADCPVLGVSARNKEGLDSVRALMRGADCCCLAGQSGVGKSTLLNALLDLQLETGEISEKIQRGKNTTRYAQLLIHDGIRVLDTAGFSLLETEKGMEPEKLQELYPEFQPYIGQCRFQPCLHDREPGCAVTQAVQAGEIDENRVARYRELLADVRLAWKNRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFN0</accession>
    <name>R7IFN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-Antigen ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50425">
        <property type="protein sequence ID" value="CDE50425"/>
        <property type="gene ID" value="BN770_02381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="513" mass="56083" checksum="12856A92371FCCEC" modified="2013-07-24" version="1">MKTYCFHPPKNIIVGTLAAILWVAVFPFWLLGESTPLNALVSGEVPLWDTLTCLTMQDYSNITRAKWDGMLIFTMLALLLTIPTLFRREKRRKLPLMLMLLFLLWTGLSCFFGSHAGEMNAWGVPTVLWGSGRYEGFVTIACYGLIFLCLRRMDANVPALLTVCSAAVTGYLVLVLLQYAGFNPLSLFPMGRSIRTNYEFQGTIGNIDLVSAWVCLLMPGLLGSFVLGQKHHWLHLPGGLCAILLTLLMDVQSGLIVLVLTLLALICLALRQPECLARLLLMLGLTLLLFALRQAIALPWLDGSADIEFAPGQVSAVCTLLGVVLVALAPLLMCHPPRPLPRKGLLALVCAGLLVALILVAFLPLPEGGALWEMHELLNGRAQDAFGSERIGVWRMTLEMTAQSPWFGLSPDAFYAAFRDYLDATGQTILQNFDNPHNFFLQTMVNSGIPAALLLMLTCAAAIAGAIRKRETLPLAMMAVGFLAQGMFTFSICLTSPMFYAVLGLCAAKKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFQ2</accession>
    <name>R7IFQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50450">
        <property type="protein sequence ID" value="CDE50450"/>
        <property type="gene ID" value="BN770_02398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435883" evidence="1">
        <location>
            <begin position="24"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="236" mass="25506" checksum="EAC64F6E93FFE1F1" modified="2013-07-24" version="1">MKRLTSLVLALLLALTMMVGAFAETADVTGEWYGELLGIQVTLTINADGTYKMDIAGMDSEEGVWEKNEDGNLVMDKGTEGEGLVTVTETGLSTEQDGMKIDFTREAPAEDEELTISTETTEEELQGKWQATSVIMNGMSVPMSMVGQECIIEVKESNLYLLNLVGQTALAEIPIPMTFVDGILTVTLPVDKNTTQMFGVAKLTDGTVLFELVQGDTTMDFLMEAVPEDAEPAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFQ3</accession>
    <name>R7IFQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50256">
        <property type="protein sequence ID" value="CDE50256"/>
        <property type="gene ID" value="BN770_02337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="420" mass="45788" checksum="CB8D688D2C9B1639" modified="2013-07-24" version="1">MTEQQLREKLQFAYGNMPDATRAAFEHSLTHHRAPETHRSIGLSRTMRIVITAVLMALMLTAVGVAAARFFSVTDIHPAQDGTEGDYQAHYLALEERYDSDLLSVSVNDAVYDGSVLAFTMEMAAKTDDVLAVEVRICGECDGKMYCFDPLDVYGGEFQSLLMLPDLGGTFDGEKYAAEGILLDENGQMPPEGKPIAWTIEIDVLKAVWQTETMPDDLYEALSEEDDVAHYIREQAARHIITLTDAGVEDYLLEMCGAGWDEIEQISKADLLLRCGGFERAETYTVAFATEGNTQYVHPELAGLRIPLDGYTAVVDYVRASFLGGCVVLHCEAPNGTALPNGTALPDVWRIYRNDEQNPAGEAGWARASGYAGVPGGVADVNQPSICLYFAPCADLTSLRIVPEGEAGFTLNLSGEKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG03</accession>
    <name>R7IG03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsZ</name>
        <name evidence="7" type="synonym">rpsN</name>
        <name evidence="8" type="ORF">BN770_02441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50555">
        <property type="protein sequence ID" value="CDE50555"/>
        <property type="gene ID" value="BN770_02441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="61" mass="7093" checksum="450E050AFF4BEAEE" modified="2013-07-24" version="1">MAKTSMKLKQARTPKFSTRAYTRCRLCGRPHSVLRKYGVCRICFRELAYKGEIPGVRKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGA1</accession>
    <name>R7IGA1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 2 CUT1 family (TC 3.A.1.1.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50343">
        <property type="protein sequence ID" value="CDE50343"/>
        <property type="gene ID" value="BN770_00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="319" mass="35324" checksum="9B60C43B827B541A" modified="2013-07-24" version="1">MSNTEVMKQSAVKLAGKHPKNKIHRTAGDIAFDVFLYILFVAFTILCVFPFYYLFINTISSNDAVAGGLVNFWPVGIHFQNYLALRDVADLGSSVIVTVARTILGTALMVIVSAWAGYLVTKQKMWHRSLMYRALVITMYFNAGLIPWYMNMLMLGLTNNFLAYILPGMIAPYNIILVKTYIESIPASLEESAVIDGANTPTVFLKIILPLSVPILATISIFGAVGNWNSFQDSLLLMSSRPELYTLQHRLYVYLNQSSNLSALVNGSGGMSTQAAANMLNTRVIKYTVAMVSIIPILLVYPFMQRFFVKGIMLGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGA2</accession>
    <name>R7IGA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative SIS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50809">
        <property type="protein sequence ID" value="CDE50809"/>
        <property type="gene ID" value="BN770_00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="381" mass="42314" checksum="6FDBA17F4A15A6C3" modified="2013-07-24" version="1">MNKMDFDSALRRQVMSLPELMRQQYADLEPKTRTVLSTPEIFNIQRIVLTGCGDSYAALLAVKPAFEKYAKIRTEVVPTIDLARDYEKKNLGYAPQSPLVIAVSNSGQVARVGEAVRRCRKAGAFTLGITGHEESVLGQSAERILKLDIPKFESAPGTRSYMVCVMALYLLAIRIGEVRGRYTMDIASARRKEIKALADALETALPAMDDTAFAVAQQWKDMDCYDFAGSGFEYACAFFGQAKVFEAIGRPAMYINTEEWLHLNFFVNHPEKIGTMIWAAEDNKADSRTLETIGYAKQLGRPLAIVTDREMPDEKQAAVFIIPKAKSVLAESLYNFVPACLVFGYLMTMLGERSGRGCEGPWSFSKGAACVRQSEIVMVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGF7</accession>
    <name>R7IGF7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000181">
        <property type="protein sequence ID" value="CDE50874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50874">
        <property type="protein sequence ID" value="CDE50874"/>
        <property type="gene ID" value="BN770_00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="184"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="289" mass="32279" checksum="912D6052296E3F57" modified="2013-07-24" version="1">MINIRRMWQPLTSTPFLATAAHHEILPCESLQRWIRCFWGGIIGAGASPTRIIPDVCADLIYHIDETAGRIIQASFCGVSDVCGTAHLPLIPGHTVSTFAIRFHAFGAYAFADDALRGTLNGFESPEVRFGRLDRALRARLLELDGLTARAAYAQSVLLAFQCRENPLVETAADVLLCHRGTATISEWAHELFISSRQLERLLGEYWGLSPKKGSALVRYQALYQEICRGALNNVQDAVARYGFADQAHLCREFRRYHGENVSRFFKTSCENGRTMEKNGVYPPEEVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGJ5</accession>
    <name>R7IGJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50448">
        <property type="protein sequence ID" value="CDE50448"/>
        <property type="gene ID" value="BN770_02397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="30" mass="3331" checksum="D77D55387D08E939" modified="2013-07-24" version="1">MTKRLTSVFLALLMLNLFSAAHSHLEIVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGK5</accession>
    <name>R7IGK5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 4</fullName>
            <shortName evidence="6">EF-4</shortName>
            <ecNumber evidence="6">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lepA</name>
        <name evidence="8" type="ORF">BN770_02093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49707">
        <property type="protein sequence ID" value="CDE49707"/>
        <property type="gene ID" value="BN770_02093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="601" mass="67251" checksum="DE2ACCD690A957DC" modified="2013-07-24" version="1">MSDRLSKIRNFCIIAHIDHGKSTLADRILETTGVFQKREMVEQILDSMELERERGITIKSKAVHMHYTAKDGKTYTLNLIDTPGHVDFTYEVSRALAACEGALLVVDATQGIEAQTLANCYMALDHDLEIIPVINKIDLPSAQPEEVRQEIEDVIGLDASYAPCVSAKTGLNIDQVLEAVVNYVPAPQGDENAPLQALIFDAFYDNYRGAICFIRVKQGTIRTGMRMRMMATGGEFDIVEVGTFAPSYQPCDELKAGDVGYVAASIKDVRETRVGDTITDAMNPADCPLPGYRQVTPMVYCGVYPADGADYPALKDALEKLRMNDASLSFDPETSVALGYGFRCGFLGLLHMDIITERLEREWDLNLVTTAPSVIYRITKTDGTVLMCDNPMALPPIGEIAMMEEPFVHAEIFTPQDSVGTIMDLCQDRRGIFLDMQYEGTRVKLNYDIPLNEIIFDFFDQIKSRSRGYASFDYEFKDYRESQLVKLDILLNGEICDAFSIIVHRDKAYGRGRSICEKLKDVIPRQMFEIPIQAAIGGKVIARETVKAMRKDVLAKCYGGDISRKKKLLEKQKEGKKRMRQFGTVQVPSEAFLAVLKMDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGL1</accession>
    <name>R7IGL1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3 7">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">leuA</name>
        <name evidence="9" type="ORF">BN770_02406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3 7"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50468">
        <property type="protein sequence ID" value="CDE50468"/>
        <property type="gene ID" value="BN770_02406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="528" mass="57578" checksum="A70E1D756E957207" modified="2013-07-24" version="1">MNQIKIFDTTLRDGEQSPGCSMNLKEKIEVAKCLERLKVDVIEAGFAISSPGDFESVKTIAETVRDCSVASLARATQKDIDCAWEAVKNAADPRIHVFLATSPLHMEYKLKMTPEQVLARTAEMVKYAKQYTSNIEFSCEDATRSDTDFLIQVVNAAVKNGATVINLPDTVGYTTPDEMRKLIEDVMAGVENSDKVEFSVHCHNDLGMAGGGPPPGGVVLGMAVANSLAGVLGGARQIECTINGLGERAGNTAMEEVVMAMRTRPDIFGDTPCRIDTTQIARASKTVYNIIGQSAPLTKPIVGVNAFRHESGIHQHGVLANKKTYEILTPESVGIRMDNIVLGKHSGKHAFAARLKEMGYELPDEELARCFEEFKVLCDKKKNVTDQDILAIVTHSTTTDEAEVDGYKLMWFAVHTSNMTTSTSVVRLELDGQQFEAVCSGDGPVDAAFEAIDQIIRPVEHSFDLYRINSISPGKDTMGDVSVKLSCDNRTFSGRGLHTNIVEASVRAYISAMNKLRAYAARRAKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGR6</accession>
    <name>R7IGR6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ORF">BN770_02116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49747">
        <property type="protein sequence ID" value="CDE49747"/>
        <property type="gene ID" value="BN770_02116"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="12"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="192"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="196"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="409" mass="43869" checksum="EF7A22116DC2F5BA" modified="2013-07-24" version="1">MCCELPDVRGRHVVLGVTGGIAVYKSCEIVSRLRKLGVETHVIMTKNAAQFVQPLTFETLSNHPVVTDTFARPETWEVEHIALAKRADVFAIAPATANIMAKMACGIADDMLSTTVLATKAPILLAPAMNTGMWTAAVTQQNVQTLKARGVHFAGPEAGFLACGDTGAGRMSEPETIVRAIVSLLCPKRDFAGLRVLVTAGATRERLDPVRYMTNDSSGKMGFALAEAARNRGAQVTVIAGSTTAPVPDGIDIRRVESTQDLFDAVTTTAPDMDVVIQAAAPADYRFAVTYPQKHKKAHDGQPFVVELVENPDIAAAVGAAKRPGQVLVGFAAETENLLQNAHRKLESKHLDLIVLNDVSQPGAGFNVDTNIATLITPDSQTEYPLRTKKQLAEDILDAVLDIRKQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHE5</accession>
    <name>R7IHE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical Cytosolic Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000181">
        <property type="protein sequence ID" value="CDE50871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50871">
        <property type="protein sequence ID" value="CDE50871"/>
        <property type="gene ID" value="BN770_00230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="200" mass="22339" checksum="AF74534CBE8F3B39" modified="2013-07-24" version="1">MSENISVCGTDCGACSFFGGLCRGCNECQGRVFHAPTGCACPIYACVREKKGLRNCAQCPDLPCSLWQSTRDPSFTDEQFAANIAGRVENLRKRMTNRELADFVSAQLAPLPEVRRIPMMGGFIFYYRERIFGGVYGTGFMVKNVPAAWRFMPGTSAEPPYDGAKPMLHVLILADSAKLRAMVQAMWEELPERPPRKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHY2</accession>
    <name>R7IHY2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50923">
        <property type="protein sequence ID" value="CDE50923"/>
        <property type="gene ID" value="BN770_00247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35203" checksum="6946B336CF4C807C" modified="2013-07-24" version="1">MRILSLFSGAGGLDLGLIRAGNKVIWANDIDKDAVATYRQNIGDHIICGDIKNINIDSLPTPQVVVGGFPCQGFSLANRMRTLADERNQLYRFFYDTIRIKQPLFFIAENVKGILSLGNGEAIKQILADFGEAGYYTEKHLVNMADYGVPQTRQRVIIIGQRKDLGEKMLFHFPQPSYDKNALGGRQKWVTIQEAIGHLPDPDTPNNLPNHIYSAYKVEYRNFTGHRQTDPNKPSPTILARGNGKGGVCAIPHYNGKRRLSIRESASVQTFPENFEFHGTMNSCYRQIGNAVPVLFAEQLGKELVRVEQEEKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7II12</accession>
    <name>R7II12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51230">
        <property type="protein sequence ID" value="CDE51230"/>
        <property type="gene ID" value="BN770_00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="147"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="370" mass="42970" checksum="535C7D1E936DEEE4" modified="2013-07-24" version="1">MKYDYLVVGAGLFGAAFAQMAKEKGKRVLVIDKRSHIAGNIYTEDVGGIAVHRYGAHIFHTDDEEVWQYVNRFATFNRFTNAPLAKYQDRLYHMPFNMNTFYAMWGVTKPNEAREIIERQRKEITGEPQNLEEQAISLVGRDIYEALVRGYSEKQWGRPCRELPAFIIRRLPVRFTYDNNYFNDRYQGIPDAGYTAMVEKMLDGIEVRLNVDFLQHRAELTEIADKIVYTGPIDQYYDQCFGALNYRSLRFETQDLPVQDYQGNAVINDTNADVPYTRVIEHKHFAYGQADVLNLPHTVVTYEYPADWKQGDEPYYPVNDAKNGALYEQYRQKAAGERNVIFGGRLGQYRYLDMDDTLRAAIDCARKELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7II16</accession>
    <name>R7II16_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpD</name>
        <name evidence="12" type="ORF">BN770_00434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51434">
        <property type="protein sequence ID" value="CDE51434"/>
        <property type="gene ID" value="BN770_00434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="144"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="152"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="464" mass="50599" checksum="8437140A76466C1D" modified="2013-07-24" version="1">MLSYGKIVQVSGPVVDCEFQEGQLPKIREALRVQVEDEVRTMEVAQHMDEHTVRCIMLAPSEGLSRGMTVEATGRGISVPVGDATLGRMFNVLGDPIDGGEALPASTEKWSIHRQAPSFAEQSPVVSILETGIKVIDLLEPYAKGGKIGLFGGAGVGKTVLIQELITNVASEHGGYSIFTGVGERSREGNDLWNEMMESGVISKTALVFGQMNEAPGVRMRVALSGLTMSEYFRDVEHKDVLLFIDNIFRFVQAGSEVSTLLGRMPSAVGYQPTLATEMGQLQERITSTRNGSVTSVQAVYVPADDLTDPAPAQTFTHLDATTVLSRKISEQGIYPAVDPLASTSRILEADIVGQEHYETARAVQEILQKYADLQDIIAILGIEELSEEDRLTVARARKVQRFLSQPFHVAEKFTGIKGVYVPLKDTIRSFKAILSGEMDDYPESAFFNVGTIEDVKAKAAKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7II48</accession>
    <name>R7II48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000223">
        <property type="protein sequence ID" value="CDE51474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51474">
        <property type="protein sequence ID" value="CDE51474"/>
        <property type="gene ID" value="BN770_00461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007936">
        <property type="entry name" value="VirE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="454" mass="52338" checksum="FF4B15A5B74FA133" modified="2013-07-24" version="1">MSDETKIDWSPPMPDDQMAAAYQSVQAKLTHTAGGEVRNTLQNFVTALTHDPIFAGNIRRNLFKERMSMTCPVWWARKSDMIDDMDAAFLRLYLEEHYGLRSEKLIYPALNIVSTAQAFHPVRDRLNSLVWDGVPRVRVALHHFLGAEVSDTNEKYLRTFMLGAVNRVFYPGCKFELMLVLVGGQGAGKTTFIRFLALEPEWFTDDVSKLDDKEIYHRLNGHWICELSEMVATANAKSIEEIKSFLSRNKDFLRMAYDRYGGDHPRQSVFAGTTNRMDFLPLDRSGNRRFLPVTVDASKADCHILDNPAESRHYFEQLWAEIMVQYKSGAYSTHLSKEDEDALRKQQQDYCQEDTLAGRIYAWFETFEQDKVCSLQIYRECLAHPLDEPKNYETREIREIVDSGIASGEISGWQKFRNARKFAKYGRQYGWERIPPPAQLTFGGCTVVDEEPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7II95</accession>
    <name>R7II95_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51043">
        <property type="protein sequence ID" value="CDE51043"/>
        <property type="gene ID" value="BN770_00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="591" mass="66192" checksum="4DC9BC1B8CBD9FDA" modified="2013-07-24" version="1">MKELKLAWRYVRRHWWQYILGILALFIVDEVNTYVPRFTGEITNGLDQHTLDMGGVMGLVWKIVLIGVIIAVGRFAWRFFLFGSARSIEKELRSDLFAHLSSLSPHYYNEHKTGDLMARFINDLQAVRTLVGMNVISTFDATVMLLLVLWQMMTYVSPKLTGVAVLPLILIIFGDYFYGKVMHKRFLAKQQAFSTLTDQVQETVSGIRVIKSFVQERKELYAFAKTTLFTKEKNLGVVRLQALVMPLLDLIVGIASLLTLAYGGYLAIYGEINIGQFISFNSYVTMLVWPMMAVGECITSVSQGLASLRRIQEIFDAKPEIVDGDMVDPSIQTLKGDISIEHLSFAYPDQPTVPVLEDVSVHVKAGETLAVLGRTGSGKSTLPSLLMRLYDVPDGMITIDGHNLREIPLAALRRNIACVPQDNFLFSDTLQNNIAFGSDNKSLEAVQEAAKNACIHDNIMEFPKQYQTLVGERGVTISGGQKQRSSIARALMKDAPILLLDDALSAVDTDTERQILDNLHRLRKGRTTIIVAHRISTIQDADHILVLDEGKVEEYGTHEELLNNGKLYASLYRKQQLEKELHEEGGAAHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7III3</accession>
    <name>R7III3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0340 protein BN770_00514</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0340 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51599">
        <property type="protein sequence ID" value="CDE51599"/>
        <property type="gene ID" value="BN770_00514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00800">
        <property type="entry name" value="UPF0340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006340">
        <property type="entry name" value="DUF436"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04260">
        <property type="entry name" value="DUF436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01440">
        <property type="entry name" value="TIGR01440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="189" mass="19873" checksum="77E0CF51DF9B8881" modified="2013-07-24" version="1">MFDEAQRETLRAEINRILDESVGALMDAGHLESGSVIVLGCSTSEITGARIGKGSVPELGEIVAEAMLAACKGHGVHAAFQCCEHLNRGIVVEKAMLKELGLTQVRAIPQPKAGGSVPAAAWKKMEKPALAVSIQADAAIDIGDTLVGMHIRPVAVPLRISTSHVGHANLVMAYSRLPYIGGARAVYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJM0</accession>
    <name>R7IJM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase U32 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51518">
        <property type="protein sequence ID" value="CDE51518"/>
        <property type="gene ID" value="BN770_00473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020988">
        <property type="entry name" value="Pept_U32_collagenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12392">
        <property type="entry name" value="DUF3656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3656" evidence="1">
        <location>
            <begin position="388"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="770" mass="83849" checksum="D6B2D29DF73EF08C" modified="2013-07-24" version="1">MENLAPAGNWDALRSAVAAGADAVYLGYAAYSARAGAGNFDEQQLRDAVRFAHLHHVRVHVTVNTLIKDGELAGVVDVLRLLSEIRVDAVLVQDLGVLRMARRCFPDLPIHASTQMAIHNATGVRFCRNQGMTRAVLARECSAAEIALAAKEDIEIEVFGHGAQCVAVSGECLFSSVVGGRSGNRGRCAQPCRLLYTYRGKTAAWLSPRDVCMRDDLPELNKAGVASIKLEGRLKRPEYVATIANSYRNAIDAMDNGHFRKADEAEMTGLRQIFSRGGFMRGYAMGAEDAGVIDPARVSHGGVKIGRVEFAAGNMARVRLERNLDDGDGLQIRTAQGDAELIYAGHDTEAGQIAVVRLRPDIRTKAGDEVYRLTSEKQLQWARSLMIPAIPADMMVVAYPGKPLALTMTDGESSVTVTGDTVAPAQSRAMSEEDARRSLGKLSDTPFSLRALTVQTAGAFVPVSVLNQLRREACQQLVEARIAAFTRKAGREEPADDLIYPDTPDAPSMAIVRTREQADAMQGAADLLVWYPEDFRADALESGLRDMPDGVWLQLPTVCEEKTLDLLCDFVQRNAGKLGGIVLGSVGQLGRTWNVPMGAGSGIPVMNRRAAQFLLEQGCRFVTASSELSGAELRTLMQNHPPVVVPAYGREQLMLLHHCPARTYLGLTKGHAACRMCDQHSPDALAGQTLTDRRGTVYPLLRQRLPEGCLVRLMNALPTNNIRRVRQAGYAPMMVLTTENAQEAADVRAVMDGEMRELEGTSNHWNRPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJP0</accession>
    <name>R7IJP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50792">
        <property type="protein sequence ID" value="CDE50792"/>
        <property type="gene ID" value="BN770_00202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="318" mass="35158" checksum="29CAD9347C98C5DF" modified="2013-07-24" version="1">METTLDVRGVTRRYGTREVLKGITFAAQKGEIIALLGRNGTGKSTLMNTITGYLCQSGGNISICGYDVLTQPLEARRRTGYLPEQPPLYPDMTVTEYLRYCCRLRGLKASTQTAEIARVIELTGLEAYAHRLSGRLSKGYRQRLGVAQALLGQPPLLILDEPGSGLDPLQMAQMREVIRRAGQDSTVLLSSHLLSEVTNVCGRAIVLDEGVIRYDGTMDALLRGAASLRLMYRGDAPMMALIRELPGVTEVTEQDCREDGCHLLLIRHEMYADLRAQVSALCYENHCALLEETNGSDALEDAFLHVIARKDISRKEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJP4</accession>
    <name>R7IJP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000254">
        <property type="protein sequence ID" value="CDE52004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52004">
        <property type="protein sequence ID" value="CDE52004"/>
        <property type="gene ID" value="BN770_00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="10">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="9">
        <location>
            <begin position="122"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE52004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="490" mass="53401" checksum="F29EE7FEBA7F8DE5" modified="2013-07-24" version="1">MLLFLTIALPMLGGAAMGLMRFSSAKSRGIYVETIVLATSILTWVLLLTRTDTTFVLCHMNSELALAFRVDGMSCIFAGLVSILWPLASLYGFEYMQHEERPNTFFSYYTMSYAVTLAVAFSANLFSLYVFYECLTLITLPLVIHKKDTMSIRAGRKYLTFSISGAALAFIALVFIIYYGTTTDFVLGGVLDAEKISGMEELLKFVFLLAFVGFGTKAAVFPMYAWLPAASVAPTPVTALLHAVAVVNAGAYAVLRVIYYSFGASFLYGTWAQTVALLLSCFTILFGSTMAVREQHFKRRLAYSTISNLSYMLMGAALMTPDGMTGSLSHLVIHGVIKITLFYCAGAILIKTGKEYVQDLRGYSRIMPATCGIFLLGSIALVGTPPLAGFVSKWNLLTAASATELPMGTVAIVCLIISAILTAIYLFTAALPMYFRPLNADQAQLAGQKLDPSWMMLFPMGILCALMIGLGLWSQPLVTFLRNISAGVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJU6</accession>
    <name>R7IJU6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NusG_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51588">
        <property type="protein sequence ID" value="CDE51588"/>
        <property type="gene ID" value="BN770_00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="NusG_II" evidence="2">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="122" mass="13269" checksum="D8E6DD5F63DE8615" modified="2013-07-24" version="1">MDKKNYWVIALMVALAVGLLAAVTLLRPSGGQNGEIVVTVDGAEYARVPLGQKQTLTVTQEDGSVNVIEISERGAVMASSTCHNQLCVQMGEVTLDNWETRPNQQFIICLPNRVSVELVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJY0</accession>
    <name>R7IJY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51623">
        <property type="protein sequence ID" value="CDE51623"/>
        <property type="gene ID" value="BN770_00526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="2">
        <location>
            <begin position="68"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="379" mass="43560" checksum="1A6EE6841FBDA315" modified="2013-07-24" version="1">MNLRDKLKAIEKPKSPPKASEKQFTDCYHGREMRELSEFPGAFDLDLSALRLMTQETLPDDLDSRNILYLDTETTGFMGAGTVAFEVGMGCLTDSGFQIHQLVMRDYPEEKFLLQSIADTLMGYDAICTFNGRTFDVPLLRDRFLMNRMDDSCLDKPHIDLLHIARRVFKLRLQRCNLGKLEEAVLGIPRFDDLPGAQVPQRFFDYLKTGNFDLLTDVLEHNAQDVASLCVLLTAMVEMYRAPENVRHDEDVFSMGVALERFQHVPEARKCYQLTSGNLHAQGQERLAQSYRRGGERDEAVKVWLGMIARHEGGTKPYIELAKHYEHYERDYESALDMTRRAMALSAEPSLFDPPSVQEEQNALQYRYDRLKKKAAKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJY1</accession>
    <name>R7IJY1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Na_H_Exchanger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51935">
        <property type="protein sequence ID" value="CDE51935"/>
        <property type="gene ID" value="BN770_00702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="400" mass="41829" checksum="7F916D96462764BE" modified="2013-07-24" version="1">MNILFALAIAMAVGMAMTRLIKLIHLPNVTAYLIAGLLVGPYVLKVLTPEMNSKLSIISDVALGFIAYSIGSEFKLSYIKEIGAKPMVITAFEGCVASLLVFLTLLALGQPLPMCLALGAIAAATAPAATLMVVRQYKANGPVTRMLLPVVAMDDALGLMLYAIMMAIARTLDSGAALSVMTLLVKPLIEIVGSLAMGVVIGTVMVFCLRFFHSRGNKLTMTILIVFLAAGLSTMLDLSSLLVCMMIGATMINVSNDSPALLEQCDRFTPPLFLLFFVLSGASLDLSVLPTVGVVGIAYVLSRAIGKSLGATIGAAIEKCDKNIIRYLGMTLIPQAGVAIGMARMCLTDLPAYGPTINAVVLAGTLIYELTGPVITKIALTKAGEIKEGGAKPAAVTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJZ0</accession>
    <name>R7IJZ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-Q tRNA(Asp) synthetase</fullName>
            <shortName evidence="5">Glu-Q-RSs</shortName>
            <ecNumber evidence="5">6.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gluQ</name>
        <name evidence="8" type="ORF">BN770_00535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51633">
        <property type="protein sequence ID" value="CDE51633"/>
        <property type="gene ID" value="BN770_00535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01428">
        <property type="entry name" value="Glu_Q_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022380">
        <property type="entry name" value="Glu-Q_tRNA(Asp)_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03838">
        <property type="entry name" value="queuosine_YadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="7">
        <location>
            <begin position="4"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glutamate binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="5">
        <location>
            <begin position="238"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="309" mass="34459" checksum="71B5914C53227983" modified="2013-07-24" version="1">MIGRFAPTPSGRLHLGNLLCAMLAYLSARSQGGQFLLRIEDVDIPRCPRALAQQAIDDLRCLGFRWDAPPLYQSARSGVYQDVLNRLRREGHVYPCFCTRAQLHATVAPNLGDTQFIYPGTCAHLTPEEAAERAKTRAPAMRLRVPDETITFTDRVFGAQAENLARDCGDFLLQRSDGLFGYQLAVVVDDALSGVTEVVRGRDILSATPRQIYLQHLLGYPQPAYAHIPLLMDAQGRRLAKRDRDLDLSALSKRFSPEEILGFLAWSAGIQPEMRPTTLDALIPLFSWDKIPRTDLRLPAEIFPEGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK15</accession>
    <name>R7IK15_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pur operon repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50947">
        <property type="protein sequence ID" value="CDE50947"/>
        <property type="gene ID" value="BN770_00253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045982">
        <property type="term" value="P:negative regulation of purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015265">
        <property type="entry name" value="PuR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010078">
        <property type="entry name" value="PurR_Bsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43864:SF2">
        <property type="entry name" value="PTHR43864:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09182">
        <property type="entry name" value="PuR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01743">
        <property type="entry name" value="purR_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="PuR_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="107"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="30135" checksum="13BA79BAD6E77408" modified="2013-07-24" version="1">MDKIRRNERMSAMMKILAAKPNRIFTLSYFCDLFGSAKSTMSEDIDILRDVVAHFGLGELETVTGAAGGVRYRTKVRRPEARKFIGDLCQQLSEEGRVLPGGFLYYSDILSTPEIVTRMGEIMATEYYAAAPDFVLTMETKGIPVAFATANALGVPLVIARRSSKVYEGSAVNINYVSGSSGHIETMSLSRRAVQEGQKCLIVDDFLKGGGTAKGMVDLMREFSVDVVGMTFVMSTAKPVKKRVMGEKSLMVMDIDQEHETVLVKPAFWLNGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK32</accession>
    <name>R7IK32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000252">
        <property type="protein sequence ID" value="CDE51985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51985">
        <property type="protein sequence ID" value="CDE51985"/>
        <property type="gene ID" value="BN770_00736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="53" mass="6267" checksum="9A244779F939DCB3" modified="2013-07-24" version="1">MNEGYLVDIAMIYTMLSFLAVVLLTKIYMGVYREKRRRREAAENQAKEDEAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK37</accession>
    <name>R7IK37_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MnhB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000253">
        <property type="protein sequence ID" value="CDE51990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51990">
        <property type="protein sequence ID" value="CDE51990"/>
        <property type="gene ID" value="BN770_00738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="9">
        <location>
            <begin position="206"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37883" checksum="BACA6B42085CD8BD" modified="2013-07-24" version="1">MAKIRNNYEKSWFPRLLKWLDGGSGLLDDAMAHELDEGSEEHLLPDSQDALTRETKFEQHRQESLDKDETLYERYHQWAHTRGKKLLTWLYRLLAVVVCFSIIWVLLQTASYLPPFGNPDNPVNNEVSQRYIEKGMEETGAVNIVAGMILDYRAFDTLGESNVLFIAACSVLILLRVSGSKDGKPSTEQLEAEADDRMYEPKNDAILQHAANFLVPLILMFGVYVILNGHISPGGGFSGGAIMGAGLILYLNAFGFKRTERFFTFTTFKIVSCVALSFYALSKAYSFFTGANHLPSIITTGTPGMIFSAGLIPYLNIAVGLVVCCTMYAFYTLFRKGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKE5</accession>
    <name>R7IKE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutamine synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51956">
        <property type="protein sequence ID" value="CDE51956"/>
        <property type="gene ID" value="BN770_00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="164"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="692" mass="76680" checksum="5D0AEA074719FB97" modified="2013-07-24" version="1">MANIEELFGSSVFNDAVMQKRLPKDIYKALHKTITDGTPLDPQVANVVANAMKDWAVERGVTHYTHWFQPLTGITAEKHDSFISPKDGGKIILEFSGKELVRGEPDASSFPSGGLRSTFEARGYTAWDPTSYAFIKDGVLCIPTAFCSYGGEALDQKTPLLRSMEALSAQAVRVLKLFGRDATRVTSTVGPEQEYFLVDKALYDQRKDLIFTGRTLFGNKPPKGQELEDHYFGSIKPRVQAFMTDLNEELWKLGILAKTEHNEVAPAQHELAPIFSITSVATDHNQLTMEMMKKIAQRHGLVCLLHEKPFAGVNGSGKHNNWSMSTNTGYNLLDPGDDPATSAQFMLILTAVIKAVDEYADLLRISVASAGNDHRLGANEAPPAIISMFLGDELSAIVNAFEEEKEYCASEKHDLEIGVSVLPKFPKDNTDRNRTSPFAFTGNKFEFRSLGSSESIAEANVVINTIVAQSLKEFADELESAENFRETLHNLIVSNLRKHNRIIFNGNGYAPEWVEEAARRGLPNYVSTVDALPHMLDEKNIKLFTTFGVFTEAEIRSRYEIKLENYAKVLNIEAETCLMMAEKEILPACMKFAGATAKAVNAMKTAGVEPYAEAHVLADVAERNAKLYKALEGLRGAVKATCHGDALECAKYEHNVIIPAMAAVREQADELETLVGKEYWPFPTYDDLLFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKG6</accession>
    <name>R7IKG6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51783">
        <property type="protein sequence ID" value="CDE51783"/>
        <property type="gene ID" value="BN770_00610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="250" mass="28437" checksum="1892F0D8E69ED341" modified="2013-07-24" version="1">MTSEILRNEECNPNLLKKKGLELLDAGKTNEAVECFSKGLVYAPFDSLMRFWRGRKLIGREEYTQSASDLKLAALENPEDWECWYYLGVACYLGGMYEEAKVAHANSKTLMKKYGVNALPATTDWYWMICMKLGQPEEAAKALEDITPDMPTEDGDYLCRVLLYKGVLKPENFVEECEKNCKNPERPRIYHLMLTYGLANYLHYQGRDAEAIPLLKELAESPDNRALFAVKQSMQDLDAMGVSYTVPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKL2</accession>
    <name>R7IKL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51838">
        <property type="protein sequence ID" value="CDE51838"/>
        <property type="gene ID" value="BN770_00647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015231">
        <property type="entry name" value="DUF1934"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09148">
        <property type="entry name" value="DUF1934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="152" mass="17150" checksum="56D1723828DEB31F" modified="2013-07-24" version="1">MKKQDKTPVLINLVSTIRDEEGEQEAPMQLFCRGELKKTASGYLIRYQESMPTEDDSEMVTSDVILSLSEHRVTMSRPGEYGTTMVFVKDQRFEGAYHTPFGDMAMAVFPTQVKCRAADDAGMVHLEYQLDVQGRFTAMHTIHIDYCATGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKQ2</accession>
    <name>R7IKQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51883">
        <property type="protein sequence ID" value="CDE51883"/>
        <property type="gene ID" value="BN770_00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="451" mass="48088" checksum="9739FB28E8287AE6" modified="2013-07-24" version="1">MNVDLTHGSIFRGLLRFSLPLMAGNLLQQLYNLVDTFVVGRYCGEIALAAVGSAFSVMILLTSIVTGLCMGSGVVVSQLFGQKDDAGVRKTVGNAFVLIAGVSALLTILSYALLPVMMALLRIPPEAQGVLSRYLLIVFIGIIPTFLYNFGACMLRAVGNSTAPLVFLLISSLTNVALDFLFVAVLPWGVAGAAVATLISQVLSGFLCLGYVLFRVPALTPSQHDLRPDRALFRRIFSVSAMTSIQQSIMNFGILCVQSLVNSFGLAAMAAFTAGVKIDSLAYSPAQDFGNGFTTFVAQNQGANQPQRLRHGIRTAFLLSGGFCLIVSTLVAIFAEPLLLVFLKNASAESLSIGVTYLRTEGLCYIGIGFLFLLYAIFRGLEQAGMSIVLTVLSLGLRVVLSYAFAPHFGMMAIWLAIPAGWLIADIVGFVAMGRRGLMRSASNKTGKSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKV2</accession>
    <name>R7IKV2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Segregation and condensation protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">scpB</name>
        <name evidence="6" type="ORF">BN770_00710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ScpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51943">
        <property type="protein sequence ID" value="CDE51943"/>
        <property type="gene ID" value="BN770_00710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01804">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="206" mass="23219" checksum="CE6A708A7F9F5FFE" modified="2013-07-24" version="1">MNETQNEEQLRFPDDIMEEGGNLAGRIEAILFVAGEAVRVEDLSKALDVPIREVEDALIQLRDEYDFNQRGFSLKRYGHQVQLATRALYSQDVVRLLQPVQKQSLSQAAMETLAVVAYRQPVTRAEVEQIRGVKCDYSLQSLMNKELIAEVGRKEALGRPILYGTTDNFLAHFGISSLKELPPMPEKPKDDSDDAEMTDDVPELIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKX9</accession>
    <name>R7IKX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51978">
        <property type="protein sequence ID" value="CDE51978"/>
        <property type="gene ID" value="BN770_00730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010375">
        <property type="entry name" value="CdAMP_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38456">
        <property type="entry name" value="PTHR38456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06153">
        <property type="entry name" value="CdAMP_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="109" mass="11520" checksum="086412FFFD31FF93" modified="2013-07-24" version="1">MKLIIAIVQDEDASRLVNQLMKAGIGVTKLATTGGFLRAGNTTLLIGVDDAKLQGTLDIIEKVCKSRKQMAASPTPMGGASNVYTSFPMEVTVGGATVFVLTVDQFMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL97</accession>
    <name>R7IL97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51397">
        <property type="protein sequence ID" value="CDE51397"/>
        <property type="gene ID" value="BN770_00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436021" evidence="1">
        <location>
            <begin position="24"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="513" mass="57820" checksum="6203DB734E417E6F" modified="2013-07-24" version="1">MKKRWILLILPLMMALMMNAASANQWGLRGQALNIVEHTHDYDEYSCVADDYKSQTNATRVILGSRYHNQLVAVDEVKDGWKDAIFSTTAVYQPSELEETGYPKITRTKNGFELAYPDIDERYYFELQHNNEGRTFYTLMEAQMGDVKVERIASYGYRVTLGEDSAMWMTKITLEDFNIHNMPKRGPDDVRRINEASEGLQYFACLYPEVVSGQKSGKKSYAVYSAPDTSSYRAAKGKASVSTGDDYKLYLTVGDWSLIEYRVSLRTSRFGWAQLGNHGDETTNEIVHVPMLTAFDTYLTDDPNVSEYHQVELPAGTKLTALSHPDNQWAYVYVEATVDGKITRGFVPQRDVVFDDVELPDEEAKLVGSWQMEAGGEFWDNYLRLDADGKFYGSDCDGAQPYHGTWSVVQTPADSNLYWRGDIPTIVFRCVNGTVYRYGVGVSESADYEVTEGDYCRSMSLITCEGGTGYVSYGVYGEGGGIITDENGKLILKELNVTNELNWGAYWEEEGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILV4</accession>
    <name>R7ILV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000233">
        <property type="protein sequence ID" value="CDE51617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51617">
        <property type="protein sequence ID" value="CDE51617"/>
        <property type="gene ID" value="BN770_00522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018709">
        <property type="entry name" value="CoA_activase_DUF2229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09989">
        <property type="entry name" value="DUF2229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="4">
        <location>
            <begin position="10"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="BcrAD_BadFG" evidence="4">
        <location>
            <begin position="326"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2229" evidence="5">
        <location>
            <begin position="677"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1418" mass="155604" checksum="242FDAB22AA40C14" modified="2013-07-24" version="1">METNTYYYAGIDIGSTTVKLVLLNEAGEMVWGEYRRHCAHTQETLAEMMREARKKLGACRVKVRMTGSGAISLAEALRVGFVQEVVAVAEALQKAAPQTDVAIELGGEDAKIIYFTGGLEERMNGVCAGGTGSFIDQMAALLKTDAPGLNELAKRYHELYPIAARCGVFAKSDIQPLINEGAAREDLAASIFQAVVNQTISGLACGKPIRGHVAFLGGPLHFLSELRQAFVRTLHLTEETAIVPENSHLFAATGAAMAALSGGEDEAVPMDSLLERLEHGVMLTFGLKHLAPLFRNQEEYAAFNRRHAQAKVQRGDLATYSGKCYLGIDAGSTTTKVALIGEKGELLYSYYAGNSGSPIETARTAMRELMEKMPDTAVIARSCSTGYGESLLKSAFRLDDGEVETIAHCTAAAFFDPKVDCVLDIGGQDMKCIKLKNGSVDTILLNEACSSGCGSFLENFANSMGYTAEGFAAEALFAPAPVDLGTRCTVFMNSNVKQAQKQGATIQDISAGLACSVIKNALFKVIKLADPKELGQHIVVQGGTFHNKAVLRAFEQLAGVEVVCPDISGMMGAFGAALIARDRASGSDTPSSTLPIQDILGLQWQTRTARCQGCTNHCMLTVSLFPGGRRHITGNRCEKGLGKTATGEKGPNVMAYKLKRMFDYQPLTAEQATRGELGIPRVLNMYENFPFWMTLLTKLGFRVVLSPASSRAIYEKGMESIPSESECYPAKMAHGHVQWLIDQGIGTIFYPSVFYERQEDMKTQNHFNCPMVVANPENIANNVEDVTEGRVRMLKPFLALTDEKTAADALVRFFRKTFNIPEQEVRDAVHAGWDEQQCAKTDVRAEGLKALQWMEENHRKGIVLAGRPYHVDPEINHGMPELIASYGLAVLTEDSIPASFHGEHPLRVSDQWVYHSRLYVAAQFVSQRDDLELIQLNSFGCGLDAVTTDQVAEILERCGKLYTLIKIDEVNSLGAARIRVRSLLAAMAQREKRGIVAHPVPATYHRVEYTRDMQKKGYTILAPNMSPIHFRLLQPVLEKHGYHIVMLENDTRSAIDTGLKFVNNDACYPSIITVGQMMEAVLSGKYDTDRLALAMTQTGGCCRASNYVGFIRRALAKAGLGHIPVISINANGMETNEGFHFTLPMLIGAAQAIVFGDLLMRCLYRVRPYEIEAGSANRLAGTWSQKIIDHLVNGTSRYGDLCQQLVDDFDHLPIHEDMRKPRVGIVGEILVKYMPVANNHLVDLLEEEGAEAVVPDLMDFMNYSVYNGKFKHEYLGKGWTSEASAVLGVKGIRALRRPALKALEKSKRFEPPMHIEQIAELSDPFLSQGNQYGEGWFLTGEMAELLLTGVPNIVCIQPFACLPNHVVGKGVIKQLRKKYPQANICAVDFDPGASEVNQLNRVKLMLSAARKNMEQEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILY3</accession>
    <name>R7ILY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51642">
        <property type="protein sequence ID" value="CDE51642"/>
        <property type="gene ID" value="BN770_00544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="221" mass="25043" checksum="A5356C5EFDB023AD" modified="2013-07-24" version="1">MTLAAKLTDKQKWQRLLSSLRYSLYVIFHPFDGFWDLSREKRGSLGAANIIVFLVLLVRLLSMQFTPFLFMNVYWPSVNIIQQCLAVLLPLLFFVAGNWGLTTLFEGKGTFKDVYIATCYALTPYVILQAAMILLANVITAKEGAFYYVLEGLSLGWSGALIICGMMQTHDYSLGKTLLFTIMTLLAMVVIIFLLLLFFSLVGDGIGYFVSLYKEVLFRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMF5</accession>
    <name>R7IMF5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51787">
        <property type="protein sequence ID" value="CDE51787"/>
        <property type="gene ID" value="BN770_00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="328" mass="36388" checksum="090B00AEEB9A38DB" modified="2013-07-24" version="1">MSEPVLQVKGLKTYYYTEEGVVPAVDGLDFEVEPGETFAIVGESGCGKSVTSLSILRLIPSPPGKIIDGEIIYHGQDLVKKSEREMRSIRGNDISMIFQEPMTSLNPVFTVGQQIGESFRFHQQMGKAEMLKKSIEMLRLVGIPEPEHVINDYPNQLSGGMRQRVMIAMALACNPKILIADEPTTALDVTIQAQIMRLLKQLQEKMGTSIILITHDLGIVAQIAKHVMVMYCGQAVEYSDVRSIYKNPLHPYTAGLLRSIPKLTDDDMEELPSIPGMVPSPSEKLQGCRFAPRCEKCGARCKKEMPDLVTLEDGRKVRCFLYEGGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMN8</accession>
    <name>R7IMN8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3899 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51892">
        <property type="protein sequence ID" value="CDE51892"/>
        <property type="gene ID" value="BN770_00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025007">
        <property type="entry name" value="DUF3899"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13038">
        <property type="entry name" value="DUF3899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3899" evidence="2">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="133" mass="14750" checksum="86D0575808DD5E36" modified="2013-07-24" version="1">MKKSKRAMPYWICIAIGALIFAGVASMRSIWTLSEREEILSGLCDALFVPGALLTCVGLLTFTAREGVLDIISYGFRNLLVLFAPGKHKHQHYYDYKMAKEANRGKGTHAPLVVGLAFILLAGVCLIFYYYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I2Z4</accession>
    <name>R7I2Z4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA damage-inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46239">
        <property type="protein sequence ID" value="CDE46239"/>
        <property type="gene ID" value="BN770_00795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="456" mass="49686" checksum="2A1CD3ADB57C22F8" modified="2013-07-24" version="1">MKLSKGNRDLILHGSLVKAVFAIAIPVVVNSFLQTMYNLTDTYWLGQLSVDYLAAINLVSPVQNTVINFGSGVTVAGAVMISQYIGAGKPEMARKIANQIFTVAMLFSLLCASVMAVATPGIVGWMGAAPDYFDHAVTYMRLVVLDMPFLFMVNIYQSIRQAQGDTVRPMLLNLLGIAVNMVLDPLLMVVLHWNAAGAALATVFAKMVPACIAFFLLCTRRDEAICFDRRFLRPDAACLRDIVRIGLPTALGSSFMQFGFILMSRNVNVYGKMAMAAYGIGNKVNGLISLPSTGIGSAVSTIVAQNMGAQQVDRAERGYKLSTGMALLFLLLGGFVLSRPSVASAIVSIFTDEAEVIPMAADYLSIMAFWCWTNSIHDATRGLFQGSGHTFLPVAVDMTRLWVLRFATLAFCEQVLHLGVRSVWYSVVVSNGIASAILLALYFTRIWRKSTIKIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3I0</accession>
    <name>R7I3I0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methylase putative group 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46190">
        <property type="protein sequence ID" value="CDE46190"/>
        <property type="gene ID" value="BN770_00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="376" mass="41664" checksum="E6C756BCF95D4F42" modified="2013-07-24" version="1">MAYYDNAPSHKPQGKKSFGREKWVEEGSEYRGARHGGRPSGKRDDNRAYGEKKSFGDRKPYGEKKSFGDRKPYGEKKPYGEKKSYGDRKPYERRDRYDRRPEMTDERPAPSYRDSEYRPVAVAPVMAQPVAEEAVQENLLAGRNPIREALKAGRDIEKLLVQKGELTGSAREIVQMAKEAHIPVQEVEHQRLNELAKNHQGMVAFASAYQYSTVEAMLAEAEEKGEDPFLILLDGITDPHNLGAIIRSAECVGAHGVIVPERRAVGLTPAAVKASAGAIEHIKVARVVNMTRVIEMLKARNIWTYALTMDGTDYEKVNFKGGVALVVGSEGEGISHLVLENCDQKVSLPMAGHLDSLNASVAAGVVMYRVLSSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3X4</accession>
    <name>R7I3X4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000008">
        <property type="protein sequence ID" value="CDE46320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46320">
        <property type="protein sequence ID" value="CDE46320"/>
        <property type="gene ID" value="BN770_00825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="201" mass="23522" checksum="D84C6605A57F219D" modified="2013-07-24" version="1">MTEKDTMQVKPEKKEDRRVRRTKKLLTHGLIQLMKEKQVQDITVRELADLVDVNRGTFYLYYRDIFDMLDSIEQELFNQVNQLIAAHKGETVLTHTLPVLKELFRLVEDNKELCQVLLGQNGDMKFLKKLSDVVQEAFRREWLMMKKDEVTFDYSYAFGALGFVGLLRTWLERDCVEKADDMAVLSDRMIRLGLTSSLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5A2</accession>
    <name>R7I5A2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recF</name>
        <name evidence="11" type="ORF">BN770_00983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46671">
        <property type="protein sequence ID" value="CDE46671"/>
        <property type="gene ID" value="BN770_00983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="395" mass="44281" checksum="7523EC51167F1D74" modified="2013-07-24" version="1">MQIETIRLRDFRNYHSLILTPHPGVNILLGQNGSGKTNLLEAVHYCALGRSHRTGLDREVVRKGAMMAASGVTLRKKSGKTEIAVKLTPSEARKKTVFIDCKRAERISALMGHVQCVIFSPEDLMLVKEGPAIRRRMLDMMLSQLSTAYFSALQQYQKALEQRTALLREAKRGITPDPVLLDTFEEAMATPCGIIMPLRDKLVKQLAKIAAEKYERISGRPNEMFRMTYQPCVPETSNPVSAIRAELKKSRQEDIRVGGAGCGIHREDIGLSLMERSMKVFASQGQIRTAALAIKLAQLETFRAETGETPILLLDDVMSELDMTRRTRLLREIEGVQTFITCTDESDLDGCREKRSYRVWMDSDGEGHVQEESAGDEVMKPDLLDDPELDEPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5A3</accession>
    <name>R7I5A3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase TrmH family group 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46795">
        <property type="protein sequence ID" value="CDE46795"/>
        <property type="gene ID" value="BN770_01022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="246" mass="26698" checksum="F8BFD53C8E57A457" modified="2013-07-24" version="1">MEHITSLKNPKVAAWKALKDRKGRRESGCFLVEGRKMVEEALKSAFDVEAVLVQEGVSFPDGLTMPVYELPEHVLAAVCDTKTPQGIAAVVRMKEQSALGKHIVVLDGVQDPGNVGTIIRTADAAGLDGVLLSNQCADVFSPKVLRATMGSIFRMNLRTTDDLPGELTKLREKGYSILSSQLDGTPFYERQGVAERFALIIGNEGNGVSEQVQQTATHRVRLPMRGGAESLNAAIAAAIMMYELMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5B7</accession>
    <name>R7I5B7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47074">
        <property type="protein sequence ID" value="CDE47074"/>
        <property type="gene ID" value="BN770_01130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="194" mass="22513" checksum="54853BDD6BF9A614" modified="2013-07-24" version="1">MPPTVRFTRDAVLHAACQLMRREGMEALNARAIAKELGGSTQPIFRLFTNMEDLHRELILYVARQFQAHAEADMAQSDSPYIQLCTTYLLYGRDEPELFKLLFMRDRVSEGQYSDQTNFDLVFNIIKKETPLDDETALRFFERTWLFIHGLAVCIATKYIPCQDERYLISMVKEAYNAAVKMMNLEGVLKLQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5C9</accession>
    <name>R7I5C9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GerA spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47084">
        <property type="protein sequence ID" value="CDE47084"/>
        <property type="gene ID" value="BN770_01140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="492" mass="54022" checksum="EC52915846AEFF3D" modified="2013-07-24" version="1">MNGDLRENCRLLDEKLHRAVNPDMHVRFFRTFSRDAAVYYVDGLISTDFMQHYLLFPLQNAAETASSGEIAGCIRQRVALCEVEAFFDVREIVAQLVSGHAVVLVDGMDGALSFDVRGAVRRGISPPLTESVVRGPHQGFNESIRDSITLLRRILPTPELIGEMRQIGDAIPVSLCVMYLQNAVDESSLSRLKARLEEVHIDHVLSIGALEQLLEDHPFSLLPQCVMTERPDRAASMLLEGQIVLLLDGSPQVLVLPASLLHLLHTPDDTSSRWLYGTFMRLIRLLGLLCALMLPALFVAFVTFHPQALPAALLTSILESQAEVPLSVPLEMLLMLIMFNLVGEASIRVPSLTGSTLGTVSGLILGQAAVEAKLVHPLLIIVVAVSSLGSYAVPDYSLGLAVRIGQLLLLAAGSIFGVYGIVLFMTALCVRLCSLTSLGAPFAAPLSPPRAHNPDLLTRHPLWQQRWRTWLGSAENNMRSRGRMRGWDRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Q1</accession>
    <name>R7I5Q1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46583">
        <property type="protein sequence ID" value="CDE46583"/>
        <property type="gene ID" value="BN770_00950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="78"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE46583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="173" mass="19012" checksum="7EE5D9760E06466D" modified="2013-07-24" version="1">MHYTQTISSPLGNILLSADEVGLTGLWFDGGRYYAETLPEEHVERETPILMDTKRWLDVYFTGREPDFTPPLHPAGSPFRQAVWQLLLEIPYGQTTTYGALAKRLGGVHMSAQAVGGAVGHNPISIIVPCHRVVGANGSLTGYAGGLERKIRLLEIEQTDMHGLFRPKKGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5T5</accession>
    <name>R7I5T5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000039">
        <property type="protein sequence ID" value="CDE47219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47219">
        <property type="protein sequence ID" value="CDE47219"/>
        <property type="gene ID" value="BN770_01170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="387" mass="42974" checksum="B7D8E1888EA14418" modified="2013-07-24" version="1">MARKYMKIAMVGQKRVPSHDGGIEVVVGELAKRMVAQGHSVTCYNRTDKQQPQPENFNGISLKYVPTIQKKGLAAVSASFFGCLCAAVGNYDVVHVHAEGPALFCWLPKLMGKRVIVTVHGLDWTRAKWQNGIASKCIKLGEKMAVRHADELIVLSHGMKQYFADTYGRETLLIPNGVPSYQPCAPELIRQYGLEKDNYILYLGRIVPEKGEHYLIEAYKHLPTDKKLVIAGGASDSQEYFDELREMAKDDDRVMFLGFVQGQLLAELYSNAYTYVLPSDVEGMPLSLMEAMSYGCCVLTSDINECASVVQEHGVTFRRGDIDDLRAKLADLLANPAKVAKYKAEAPDYICHSHNWDTVTQRTLAVYRGAVPQEEPHRGFVPAALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5V5</accession>
    <name>R7I5V5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000021">
        <property type="protein sequence ID" value="CDE46633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46633">
        <property type="protein sequence ID" value="CDE46633"/>
        <property type="gene ID" value="BN770_00966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="286" mass="30690" checksum="CB5FAD70E153F822" modified="2013-07-24" version="1">MEVYLASAAGLLSWCGKWRKIPTLLAHPTLLAACGADVALADSVNRLLYRQGRVSPLPPGVEVLRCWRNQLLTLSSETNCLTLYDAHDYPLVSSPAGIRPCDCAVVDCQVIVCGCEDGCLHIFSLPDLREIAAYPVPGCPMRVAADGGVLTCLSLLSPDPPQTLLFRLCLTSGDFAPVALLPGWCGAVTIAADNTIWAGVGEQLLHFPLDSVVPDVQLGEFGLIRFLSCQQSKLLISDPWAGRCLLMDTTPPYAPRQLYAGECGGCCFASCRKGTLPDWKASLNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Z7</accession>
    <name>R7I5Z7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiI</name>
        <name evidence="9" type="ORF">BN770_01182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47254">
        <property type="protein sequence ID" value="CDE47254"/>
        <property type="gene ID" value="BN770_01182"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="57"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="398" mass="44741" checksum="376456C75A5BE6C3" modified="2013-07-24" version="1">MRNLLLVRYGEIFLKGQNRPLFMRALVKRIKYAVKDLSATVLLHDGRILVSDFDDLDECIRRVTKVFGVHSVCPAVEMPKDDFDALCNQAVAMMADLSGTFRVTARRSDKNYFMDSPAINIEMGHRILTANKNLSVDVKKPQHTMNVEIRDMAYLYVKVIPAVGGMPVGTNGRATLLLSGGIDSPVAGWMIAKRGVHINAVHFHSYPYTSDRAKEKVLDLARILSESCCGIRVHIVPFTKIQMEIHEKCPEEYTTLIMRRFMMRIAPEEYKTLIMRRFMMRIAEKVARQENSEALITGESVGQVASQTMTALGTTDMVVDMPVFRPLIGFDKEEIIAVSEKIGTFETSSLPYEDCCTVFTPRHPATHPKMEKILEGESKLDIDGLIDEAMAGIEIVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6N5</accession>
    <name>R7I6N5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NERD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47280">
        <property type="protein sequence ID" value="CDE47280"/>
        <property type="gene ID" value="BN770_01198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="NERD" evidence="2">
        <location>
            <begin position="102"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="270" mass="30725" checksum="360EBC9E82559259" modified="2013-07-24" version="1">MATFHSGSEGQTQKLQALRRRQKRLAFRAVIVPPVCWGICAASAPWWFPPLKEMLGVRFDAQTQGWILLVLMLLMISLPVLISLHLKRRARGAKYAATLVSSGIRGEEDARALLSRLPGRVHLYPNRIVHAGNRSECDLVALCRRGATVIEVKNHAGTVTGDLSDHDLLLTRKNGTELTFYNPAMQVTTHAQTLARALAEAGVPCPVKGCVLFIREGTIVRLSDRFHRRRVTPVFTRRNRFRLRWYILHRGKRLRRREVCALRRILENMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6W5</accession>
    <name>R7I6W5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47609">
        <property type="protein sequence ID" value="CDE47609"/>
        <property type="gene ID" value="BN770_01314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="389" mass="42837" checksum="68BB1E0F090C43BB" modified="2013-07-24" version="1">MTLHEQVTDILASAVEAQECAGISVLVRRCGEEMLYTQAGMSDVASGRLIHRDSIFRLYSQSKPITAAAVMLLAERGQIDLMDGVDRYLPGFRNARVVDKQGTIRPATRAPWLMELLGMTAGVCYPDSDPAGQYAAKVFDEATQEILAGGGVPTVEFCNRLGQQPLSFQPGTHWRYSTCADILGAVVEVVSGMRFGEFLRKEFFEPLDMVDTGFYVPESKRNRLVTAYKRTENGLVPWTSTHLAVGVYDREPTFESGGAGLVSTLEDYSHFADMLLAGGTYEGRRILSPATVACMTQPQLKDAVRRDMWDSLDGYSYGHLMRICAEPGRIAGLACAGEYGWDGWLGTYFANFPGQQMTILSMQNTVDSGTTRVVRRMRNAVLAALSREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7E5</accession>
    <name>R7I7E5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47749">
        <property type="protein sequence ID" value="CDE47749"/>
        <property type="gene ID" value="BN770_01336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030158">
        <property type="entry name" value="MglC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32196:SF18">
        <property type="entry name" value="PTHR32196:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="354" mass="37365" checksum="753F6B5201EEE37E" modified="2013-07-24" version="1">MSNVATKAKKPNLSVKSVLNWILDHAMIIVIVLLALYVQTQRDAFLKPASLINIISLTAARLPMALGVAGCIILAGTDLTGGRVAGLTAFVAAILLQRADVANRVLAGGAPANIVLVLLLVMLIGACVGLINGFVMAKFKVHPYIITLAMQMIVYGIYLTVSNSVQVGSFDSSYTTSFVTKPLFQIQTGVRPNGTAIFTVVPMYVLLALIVTALMWVVWNKTAFGKNMFAVGSNEEAARVSGVNVMMTIIGVFMVAGALYGYTGFIEAARMGSSTATLGLNYEADAISAAVIGGVSFVGGTGRISGVVLGVFMMQLIIAGMTFLGISGNVTYIVKGAVILFAVILDMRKYMTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7J5</accession>
    <name>R7I7J5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47605">
        <property type="protein sequence ID" value="CDE47605"/>
        <property type="gene ID" value="BN770_01311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="26"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="230" mass="25575" checksum="E754C1A43206A41C" modified="2013-07-24" version="1">MNETDSFAAFSDISLPRVTRLTPSEPAVGVMIVCSGASEKQLTDMLNTLDKYGVKGTFYVTGDFVRRNPERIQRIIDAGHELGSHGNNLINMTEVSYARVQENIRELNDLCEETFGVRPRLFCAHLGATNSIVTAIARAEGVEDCLFAIDACDWSDAYKDKVYQMVYRVTSDRVTSGCVVQFHINGYHTAEVLDKALDNWINVKGLRPVTVGELMQLSGRDFPPLPDYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7P5</accession>
    <name>R7I7P5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thump domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000069">
        <property type="protein sequence ID" value="CDE47879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47879">
        <property type="protein sequence ID" value="CDE47879"/>
        <property type="gene ID" value="BN770_01411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="166"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="382" mass="43211" checksum="7B990AC784B89903" modified="2013-07-24" version="1">MNNNKEYNLYATAAFGLEGIVGAELKRLKMQNVRAELGGARFTGTLTDAFLCNLRLRSADRVLIVLAEDECRTFEELFQLVKSIAWEDIMPADAKINVSGKCVRSQLMSVRDCQAITKKAIIERLKAATRRAVFPETGAVYPIDVAIHSDRVRITLDTSGEALNRRGYRTWNGEAPLRETLAASLVELSPWRPGMRLYDPCCGTGTLLIEAAFRQEHRAPGLTRAFAMEQFSIFPAEECRQIRETCKADVLPDHVFGIAGSDKDPEALELARRHVRQAGLEGKIELTCQSLEKLKLEGEPGVFLCNPPYGERLEDRRTCEGIYRELGRMMRRHPGWSLCAITSDPTFERSFGRRADKKRRLYNGRLECEFMTFLDPKSAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Q1</accession>
    <name>R7I7Q1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47288">
        <property type="protein sequence ID" value="CDE47288"/>
        <property type="gene ID" value="BN770_01200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="287"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="535"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="602" mass="67619" checksum="A7B4BF3E70FFF465" modified="2013-07-24" version="1">MASAYSFSDVTIFYSEKELMNNVFLTISEGDRIGVVGRNGAGKSTFLRLLSGKEEPDHGEISVKRGMSVAYLPQTPVLREDDTITRAALDYLPARQGEDPSSAAYEAQTILTQLGFADLNQPVRELSGGQKMRVALAGALCRKSDVLLFDEPTNHIDLDMAQWLEDRLLKYRGTLIVVTHDRYLLERAFSRIFEVGDGKVEIYNTTYSGYLEERAQREEMEAATLRKNKSLYRKELAWIRRGAPARSTKAKGRIQRFDAVAEAIKEAPPEAELTMKSVASRLGKKILSWENLSIGYGENTLVRDFSYTLLRDDRLGIIGGNGAGKTTLLRTLCGELPPLSGVIEKGDTVRIGYFAQHCPALDPDTRIIDAVKDVAVHVYTPDGDLSASQMAETFLFPSQMQYQKVSSLSGGEQRRLYLLRILMAAPNVLILDEPTNDLDLATLNILEDYLDSFQGAIIAVSHDRYFLDRITTHLFAVEDAHMVPYIGGYQSYLDAQEAKAEAMADMKQPAAAKPKDTRVRVQTQLKFSYKEQRDFDTIENRVAELEEKLAQLEKEIAANASDYTKVTELMDTQAKTQQELDEATERWLFLQEKWEQIQAQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I847</accession>
    <name>R7I847_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein AD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000057">
        <property type="protein sequence ID" value="CDE47681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47681">
        <property type="protein sequence ID" value="CDE47681"/>
        <property type="gene ID" value="BN770_00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010894">
        <property type="entry name" value="SpoVAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038369">
        <property type="entry name" value="SpoVAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07451">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011570">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02845">
        <property type="entry name" value="spore_V_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="343" mass="36430" checksum="DA31726ED4E92A1C" modified="2013-07-24" version="1">MAERLKRIGTGTILLPNRPGIAQTAAIVGKKEGEGPLHSEFDVVIEDDLFGEETWEKAESRFHYTAADTCLKKAGATPESVDVTLGGDLLNQIMAASTAAQKLQTPFLGIYGACSTMAETLCIGAMLCDGGYARRALCCASSHFCSAERQYRFPLEYGNQRPPTSQWTVTGAGAALLDTSARRPICRATHVTLGRIVDLAIKDMNNMGAAMAPAAADTLRRHLMDTGRTAADYDLIISGDLGKIGHDLLLTLMMDAGVPLDAARYVDCGMLIFSPEQDVHAGGSGCGCSASVLCGYIMRLFREKAIHRVAFMATGALLSPTFSQQGGAIPGIAHLIVLEADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I868</accession>
    <name>R7I868_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46702">
        <property type="protein sequence ID" value="CDE46702"/>
        <property type="gene ID" value="BN770_01002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="66" mass="7306" checksum="487B7FAC5DD8285E" modified="2013-07-24" version="1">MVNMPNVLGMRLEDALAECRAQGVEPEIVMTLPPKGREQGTIRVIRAKEGVLTVSRFEDELSPVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I890</accession>
    <name>R7I890_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16C associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47805">
        <property type="protein sequence ID" value="CDE47805"/>
        <property type="gene ID" value="BN770_01366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448067" evidence="1">
        <location>
            <begin position="29"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="M16C_associated" evidence="2">
        <location>
            <begin position="496"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1008" mass="110363" checksum="6EE350AD166F3692" modified="2013-07-24" version="1">MSKRLLRSLLSLMVCMAMLLSLAPAALAESADAPSTEMAVGAVIHGFEVVENGEFALLNAKTTVLRHQKTGATVFFLINEDTNRAFDISFVTPLSDDKGIPHVFEHSTLDGSKKYPSASLFFNLIYQTYNTYMNAATYQVMTTYPVASLSEAQLLKYADFYLDSCFNPMIYEDESLFRSEAWRYSLESVDSPLTISGTVYSEMQGAASLETSASYNAMKAAFPGSHMGYNQGGEPTEIPSMTWQEVKDYHTAYYHPSNSLTTVYGAIEDPAAFLALLDEAFSPYEAKAFDFSTPDYTPVTSPVEKVCQYPVYEGTETENAAVTYITFICENATEEEQDVLDLLTTLLSDSSSALVSNLVDALPNADISVYLETTGPEPAVVFVATGMNEGDVQTLRECIYASVLEFAENGVSQDILDAIASSLTMETALMSEESDLGVNMAQNIAYCWATTGDVHAYEKTIANMDNFEKYQTEGKYAEVAKKYLTEDNQRVITVTTVPAPGQQEAIEADLAAKLAETKAAMSAEEIDQLVADTAALASGSMEDTSELVAQLQAVTVDNLPEEIRTYDYTDVTDASGIRRIDVTADVDGIGQTYILLDAAAIPQEDIHWLNLYLNLIGSLGTTEHSSADVYALQSRYLYDGVVKLAVLNTDDAQGFRPYIRASWKATDADMSASYALLNELLFESEFTDTALIASNIALFRQTMKQSYEQEIYMTQLYRAVSQSDVGFNLYTYATGVDYYHFLSDAQALLESDPEAFAAKMKRIQALLHNGANAVIGFAGNAASIENNRAAADSFLASLPMAEVAPQTYDLPVPASAEGIVINSTVNFNLVYATFEQMGVEGGYSGAMDAMCSLVSDGLLYPLLRDQYGAYGVFHGADEDGMYIISYRDPNVAQTFTVYNYVPMLLQQLQMSLDQETLDGYILSSYSYYALSSGELTGALSVITDVVNGDDPFRRLQWMHELKQLKVEDIMAFAPMYQALLDNGCMSTAGSQSALNTMPAGTYENIIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8R8</accession>
    <name>R7I8R8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ORF">BN770_01419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000070">
        <property type="protein sequence ID" value="CDE47891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47891">
        <property type="protein sequence ID" value="CDE47891"/>
        <property type="gene ID" value="BN770_01419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="16"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="616"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="822"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="820"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="536"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE47891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="890" mass="100479" checksum="453F78E80DD31ECC" modified="2013-07-24" version="1">MEMEKTFNPQAVESEIYRDWESSGAFEAHRVEGKKPFTIVMPPPNITGQLHMGHALDCTLQDLAVRYHRMKGDPTLWLPGTDHAAIATEVKIVDAMRKEGLTKESLGRKGFLDRAWKWKEEYGGRIVTQQRRMGISCDWSRERFTMDEGCSKAVREVFVRLYEKGLIYRGNRLVNWCPCCESAISDAEVEYQEKEGNFWHLLYPVKETGEMLELATTRPETMLGDTAVAINAADPRYAHLHGCHVLLPLANREIPIICDEHADMEKGTGVVKITPAHDPNDNEVGQRHDLPVVRVFTYDGHMTGAEDAAKDADGQAIDCGKYAGMTTLEARKAIVADLQELGLLKSIEPLTHEVGTCYRCHTVIEPMVSRQWFVKMKPLAEPAIACVKSGETKFVPERFTKQYMNWMENIRDWCISRQLWWGHRIPVWYCDDCGAMTVSREDPTCCCKCGSAHIKQDEDVLDTWFSSALWPFSTLGWPDNTEDLKYFYPTNLLVTGYDIITFWVSRMITMGLEEMQVPPFQTVLIHGLVRDELGRKMSKSLGNGVDPLEVIDQYGADALRFSLVMGVSAGNDTRYIPARVESARNFANKIWNASRFVLMNVMEKAPLDTAHLTAADQWILSRFQDATRAISSNMEEGEFGLAADRIYDFAWSEFCDWYIELAKSRLNGDDPVAKKAVQGVLLYVLEGLLKLLHPFMPFLTEQVYKFLPGSEGFLMLKSWPEVKPELDFPDEEAKMEGVMEVIRTIRNLRAEMNVAAGKRTHLMLLPADGWAETLAHAGQYFQRLAGASETAIIESSAAVTEKTVSAVTKACTLYIPLGDLVDFEKEIARLSKELDNLHKEIARAEGKLNNPGFVSKAPAALVEQEKGKLALNQQKAEQVEKRIAELKESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8W5</accession>
    <name>R7I8W5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46962">
        <property type="protein sequence ID" value="CDE46962"/>
        <property type="gene ID" value="BN770_01088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018763">
        <property type="entry name" value="DUF2334"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10096">
        <property type="entry name" value="DUF2334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447680" evidence="2">
        <location>
            <begin position="28"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="518" mass="57321" checksum="54A0084EE1957A23" modified="2013-07-24" version="1">MMCKAKAWVLALAAGLLLLLIPAQARADVTRLLILNDEQTSETSAAATDVLRRFALYSSWTCTFASSEDVPDTDGYTAVIICTDPNRALNASVALAIQESKLPVFVIGAGGLAELTKTQVHEGSLTLRLQTQANAANDMLLSGNSLLLMKKSGESLGGQIFVGAQAFPLCQTAGNITHLAYFDPSQEAQCAFLSTLLQTWLWPYKNSPTAYGQYLVLDRIYPFADPERLLLLVEMLETENVPYVLCVMPIYANADYPAMKRFCEVLRYAQSRGAGIVMHVPQVTLVNVTVEDLQENIANAYSAYSRYGVYPLAIEAPDVWLMSEKGQDVLRGWRTVFLFRSDEALFGEKQAENTALRDGHQIVAPAYADATAFTNAYAQAIYLDPSEDIETLRTQVNRLKNSRTALKKLSDVEGIVYAGDLYVHFYPADGLYVNGQAASLVYQRFNYDEDYVYDRGFVQYMTEQIQASNKLILAFVAVACTIFIVGMIISRRTTRRQLLGNHPHAKDEQEGVNLHDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8X5</accession>
    <name>R7I8X5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47951">
        <property type="protein sequence ID" value="CDE47951"/>
        <property type="gene ID" value="BN770_01451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="127" mass="13748" checksum="D12A0F04040340AF" modified="2013-07-24" version="1">MKKKPNARAEMPRNLIFPRAELVYLPVTPEVARAVENAVQMSLDAPLNAPNPRRSAAGRAILHARGVSLPGVEGMNRGIRCHRPVQVTNGVPLTKEAMSVTTESSETRETPEVPLPPVAQPTIRIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Y3</accession>
    <name>R7I8Y3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallophos_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48324">
        <property type="protein sequence ID" value="CDE48324"/>
        <property type="gene ID" value="BN770_01649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="277" mass="30189" checksum="14B3D2D25AC0399A" modified="2013-07-24" version="1">MRTLLMADIHGNFAALRAILSTPEAQSCGRVISLGDQVNFGPESRKVVETLRSLGATMLMGNHEERLLHPDDFAGYNWAMLRVTAGQLSGISLADLPVDVRIGSALLTHGTPGDPYHLVYPPDLPDLLKALPEDVSLLISGHNHLCWDVTSGHRRAFNPGSAGLNETGTGARAMFAIWDGDELTPCSTPYDVTENARAYLSGGFAQEAPEMSRMCLQEMETGQYQGVLRLIRHVKHVAEGMGLTIADREAWLAADAAAPWREPISTADFWARKEKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I902</accession>
    <name>R7I902_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GHMP kinase N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47981">
        <property type="protein sequence ID" value="CDE47981"/>
        <property type="gene ID" value="BN770_01470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="6">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="150"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="428" mass="47560" checksum="CDC3898CAF9E0D05" modified="2013-07-24" version="1">MNQYATMIRNLKSPEVMERLMHLYGRRDGMLVEQTGRYIGLLKRHEELFHENREVLMISAPGRTEIGGNHTDHNRGRVLAAAINLDTLSAVSARDDMMVEIHSDGYPAIKVDLGSLDVVEKEKGKTHALVRGVAARMAELGYKIGGFNAAVTSNVMSGSGLSSSAAFEVMTCAIFDALYNGFTIDYKTRAKISQYAENVYFGKPSGLLDQMASSAGGLVTVDFKHDDPDVRPMHFDFAKYGYSLVVVATGGNHADLTDDYAAIPAEMKKVAALFNEPYLRRVRPEEFYQALPTLRGKVSDRALLRAMHFFEEDERVVRQVAALDRNDLFAFLWEIICSGRSSYMYLQNVYANPKDQSLSLALAMAEHMMLDKDGAWRVHGGGFAGTTLNFVPDKLLSQFIETMEGTFGEHCCNVLDIRPEGAAVLRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I937</accession>
    <name>R7I937_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48389">
        <property type="protein sequence ID" value="CDE48389"/>
        <property type="gene ID" value="BN770_01679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019635">
        <property type="entry name" value="DUF2500"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10694">
        <property type="entry name" value="DUF2500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="115" mass="12626" checksum="2344C8E957A91116" modified="2013-07-24" version="1">MDAEMLRNVLTMLGTVLGAILVLMLVAKITSMVHVEADDARTPIDSMEASVVGKRTLVTQEDGAPKTIYYMTFQKVNGMRMELEVPGEDYGLAAEGDQGVLVARGDEFIVFKRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I986</accession>
    <name>R7I986_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47082">
        <property type="protein sequence ID" value="CDE47082"/>
        <property type="gene ID" value="BN770_01138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010387">
        <property type="entry name" value="QueT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40044">
        <property type="entry name" value="PTHR40044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06177">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031501">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="163" mass="17550" checksum="2EFBE9277DDAF44B" modified="2013-07-24" version="1">MFKKLLTTRSLCLSAIIAALYAALTLLLAHISYGPVQLRLSEAFTVLPMVLPQSIPGLFVGCLIANIFNPSPSIFDIVFGSLTTLLAAYGTYKLRNKPLLAAASPIVLNGLIVGTMVWALSHEFPLLIQIGLIALGEFGSVFVGMVLLTVLKSRVDFNKISKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9C7</accession>
    <name>R7I9C7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000069">
        <property type="protein sequence ID" value="CDE47878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47878">
        <property type="protein sequence ID" value="CDE47878"/>
        <property type="gene ID" value="BN770_01410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="34"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37143" checksum="70EC746E1D756484" modified="2013-07-24" version="1">MNMPAPGFYAPAADRYAHMPYVRCGRSGLKLPRVSLGLWNNFGSVTPQDTARDMLLTAFDAGITYFDLANNYGPRPGAAEETLGKIMDSDLRPHRDELILATKAGYTMQDGPYGDGGSRKYLMSSLDASLRRMKVDYVDIFYHHRFDPDTPLEETMRTLADIVHQGKALYVGISNYSAEQTAQAADLLATFGVPLTIHQPRYNMLDRWIERGTPSLCDVLLNRGIGAAVFSPLNQGLLTDRYLHGIPADSRAASSCVFLNEGNVTADILTRVRALNAMASARGETMAQLALAWVLENPAITTVITGASRPAQILQNVETLRKHVPLTGEEKAAIEKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9X4</accession>
    <name>R7I9X4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48261">
        <property type="protein sequence ID" value="CDE48261"/>
        <property type="gene ID" value="BN770_01608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="416" mass="46861" checksum="E0ED81005D4F64BF" modified="2013-07-24" version="1">MSNFRRPKHLTTRRMQETRPNPPKEQAKAQRPAREIRWNCPAAAKCGGCQLTRLSYAEQLQWKQQRVAELLDGICEVRPILGMDDPFHYRNKVHAVLAVDKAGKPISGVYAMGTHRVVPVRHCLIEDRRADRIIQTIVAMLPAYKLRIYNEYTHRGFLRHILIRTGHVTGQIMVVLVATSLEFPGKKAFVQELIQRHPEITTVVLNCNQRETSMVLGTKEITLYGEGYMEDELCGKRFRISPQSFYQVNAKQCEVLYRTAIDAAQLTGAETLLDAYCGTGTIGLCASDGCKQLISVELNADAIRDAKENARRNGVENARFLCDDAGRFMQKLAKEGNAPDVVMMDPPRAGSDQKFLQSLLMLKPKRVVYVSCNPETLARDLRVLVDGGYRAEWATPVDMFPGTEHVECVVAMTKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA12</accession>
    <name>R7IA12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47352">
        <property type="protein sequence ID" value="CDE47352"/>
        <property type="gene ID" value="BN770_01221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436312" evidence="2">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="286" mass="30465" checksum="D5C609EEF89FB14E" modified="2013-07-24" version="1">MRKLLTLLLLLLLLLTSSAMAAEKSAYRLADEQGTLLAWLDVPPAVGDVLLTADGTRHRVIAVEGQQAVLREDGTETLPDVPWSARETAQPVTSAMRTIGLMGDAALVRDLREGLANQGAPLVTVNPEQADFPLTVAQDEISNSAEYDTLLSGEKAAKIRLIVRRGGDNEALMKDFALSVKAGLDHTAPTLIRDVYFAANAQEPLRMLWGARETEPIRLQNTILPLAQVISNALEPHDTAGGISGSEDVPEHSAVTGLIFAGGLLLAGVVGYGLLLTGGRRHGKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA35</accession>
    <name>R7IA35_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48729">
        <property type="protein sequence ID" value="CDE48729"/>
        <property type="gene ID" value="BN770_01793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021345">
        <property type="entry name" value="DUF2961"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11175">
        <property type="entry name" value="DUF2961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="342" mass="38577" checksum="289E9FC244AB3ABE" modified="2013-07-24" version="1">MKPYCMISNAKTFAFSAENPTGARAGGSKGGDCTKLSPTVAIRAGETVTLVDTDGPGMIQSIWFTGYVGHSFVIRMYWDNCEYPSVEAPISAFFGTAYDENFVDRDGKYAVLNSAQILVAPGRGLNCYWAMPFKKHCRITMENRGEKDQSLYYIITGCHCEVPDEIGYFHASYRQEHPVQKGRSYTIIDGIQGKGQFVGVTLATGMNGNNTCWVEGEARMYIDDDKYPSIHYTGTEDYFCGSYGFGNDVQIKSYQTYSGLYSGMYAIYGDNRAFYNGQQRFLLYRFHIADPIHFETGFRMTLDNMGWTGPRYDDYTSCAYWYQTLPSAPLKPLPSDKEMIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA93</accession>
    <name>R7IA93_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000104">
        <property type="protein sequence ID" value="CDE48406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48406">
        <property type="protein sequence ID" value="CDE48406"/>
        <property type="gene ID" value="BN770_01687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="290" mass="32243" checksum="C24109F4BA97F331" modified="2013-07-24" version="1">MNLMNIEQNAENLRLLGLIVAQRGETLYQHNWDSPCRRLLFSASKSFTGAAVGFAVQEGLLRLDDRLIELFPNEAPENPSENLCRATIRDALTMCIGQSSGYLMGAQRVGMAEEDWAKAVLALPFDEAPGTHFVYSNVGPYLAGLAVQKRAGCDLVDYLMPRLFAPLGIQRTVWEVDPLGRTFGAAGLLLALPELHKLGLLYQQGGQWQGKQLLDPNWVRESGSKQVENEEDGYGYLFWRGKYDSYRADGLYGQYSVILPAQEAVITCTAESRNQKQLLETLLDAIVPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAB6</accession>
    <name>R7IAB6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YlmC/YmxH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47462">
        <property type="protein sequence ID" value="CDE47462"/>
        <property type="gene ID" value="BN770_01263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014238">
        <property type="entry name" value="Spore_YlmC/YmxH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40061">
        <property type="entry name" value="PTHR40061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02888">
        <property type="entry name" value="spore_YlmC_YmxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="78" mass="8641" checksum="FB8D444FAEEFC52E" modified="2013-07-24" version="1">MSLSELRQKDVINTRDGQCLGKPMDIEFCALDGRVTAIVVPGEFSFVHLLRGERAGVVIPWENICKIGDDVILVDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAP1</accession>
    <name>R7IAP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000098">
        <property type="protein sequence ID" value="CDE48348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48348">
        <property type="protein sequence ID" value="CDE48348"/>
        <property type="gene ID" value="BN770_01667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="219" mass="23168" checksum="A47F4F423F02ABA3" modified="2013-07-24" version="1">MPAGALCPPRGLLQGSPSLPCRLAPDCRHKCHPASSPGIHSGSARVPSFRIRLFSSTATVSAARQEFFRSCHAGRNKSPQSRRSSFPRAHRQILKWCTVPAASPTSSEHQRRASSPCTPRTPPPASAPSPSAAAAAGSSPPARGASRIRASSMSAARNPPPFPARRAVHPPCRSRAGGSTRPAPGLSTPETWRKPPAPAFRGRSARRRTPSGRFSAQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAP6</accession>
    <name>R7IAP6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryl transferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48650">
        <property type="protein sequence ID" value="CDE48650"/>
        <property type="gene ID" value="BN770_01770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="302" mass="32801" checksum="59690675723A2D5A" modified="2013-07-24" version="1">MLTPYGLTAAGAMLLLLLLTGLSCRRKGIPYRTFITFGALSLPLAFLLSRLTFTLSNIPLYVNTLSNPLLMLHFWDGGASLLGALLGVLLAGWLTGRIRRESVGRLMDAIAFGAPLAIAVERIGEGCFDEIMGMGKGIETEWLAFLGDLTGGNHPVFLYEAATMVVLFMVVLLAQRKKHPDGDTMALFLLLYGCVQVVLESLRNDSHMLLIHFVRVNQVGALVLAVAVIIRWTVTAVRGKTCTGKKAGLLWALIIISIGLGIGMEFAVDRLGEPLLSYGLMALALVLIAWCGLRFRRMANKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAP7</accession>
    <name>R7IAP7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47582">
        <property type="protein sequence ID" value="CDE47582"/>
        <property type="gene ID" value="BN770_01295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="169" mass="19021" checksum="E2E3E3F2FC3277EA" modified="2013-07-24" version="1">MNPYLTQRANRRWWVYPLMALFFALSALLLWRTCKAGERGDTHMVVLLLCLATAALYAGMHLLQGEIIRRRARGVAQQLAAFSLHMFPLSDMPKLLPDCPNMETLRLLLCGNYLRNIQIDPLTAMVYLTAPNLRAYGVVQSFIVCPHCGRRTSVVEGAARQCEHCGMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAR8</accession>
    <name>R7IAR8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SufBD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48383">
        <property type="protein sequence ID" value="CDE48383"/>
        <property type="gene ID" value="BN770_01674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="43"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="468" mass="51817" checksum="88790A5D9CCAF37E" modified="2013-07-24" version="1">MTEKSQVADIDRSIYDIRDAEHDAYRMEAGLTPAIVEKLSKEKNDPAWMEQFRLEALQIYNNMRVPDWGPSLDGLDIDHIATYVRPNTKMQNNWENVPQDIKDTFERLGIPQAERKSLAGVGAQYDSELVYHNVRAEVAAQGVVYTDMESALHGEYADMVRRYFMKLVTPRDHKFAALHGAVWSGGSFVYVPKGVQVSIPLQSYFRLNAKGAGQFEHTLIIVDEGASLHFIEGCSAPKYNVANLHAGCVELYVKKGAKLRYSTIENWSKNMYNLNTKRALVEEDGTIEWISGSFGSHVGCLYPMSILKGDRARMEFTGVTFAGAGQNLDTGAKVVHVGKNTSSYMNTRSISKSGGISTFRSSVVVEKSAKQAKSAVSCQSLMLDSESRSDTIPAMDIRTRDAAIGHEAKIGSISNDAVFYLMSRGMSEEDARALIVSGFADNVSKELPVEYAVEMNNLIRLEMKGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAS9</accession>
    <name>R7IAS9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48680">
        <property type="protein sequence ID" value="CDE48680"/>
        <property type="gene ID" value="BN770_01788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="139" mass="16599" checksum="24EEC7D1C9051D02" modified="2013-07-24" version="1">MVSIKEIAHYGRWFPYCKTDYDLWWFDKKKSQMIDAEKLGSVFDCNVHSLPSVIAQCYGHYVPCFRVDIPALEMKYAQVYLSRKTVKFLSQLSAKDMDREFLIAIEKEFLDTDWYRYELAHLSSAAEEWCKENHIRYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAZ6</accession>
    <name>R7IAZ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48666">
        <property type="protein sequence ID" value="CDE48666"/>
        <property type="gene ID" value="BN770_01778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="52" mass="5980" checksum="BF1408DB97D54B8B" modified="2013-07-24" version="1">MPTIDMQDTNRRAMTALNYASFLDDRHYLSHQGITAELVQRQRLTKSREAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBK6</accession>
    <name>R7IBK6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">BN770_01415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000070">
        <property type="protein sequence ID" value="CDE47887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47887">
        <property type="protein sequence ID" value="CDE47887"/>
        <property type="gene ID" value="BN770_01415"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="284"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="332"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="402" mass="43851" checksum="94FFD2A0B6AA60E4" modified="2013-07-24" version="1">MKVLIVNAGSSSLKYQLVDMDNEQMIVKGQVERIAIEGSHLNQKTPDMSKVIDLYEPIPDHVVATKLMLRALLDPEKGVLKSVDEIGAVGHRVLHGGEEFTASCIITDEVKAAIRKFIPLGPLHNPANLMGIEACEEVMPHTPQVAVFDTAFHQTMPPKAFMYGVPYRYYKEMGVRRYGFHGTSHRYVSKRVCEFLGVSPIGKKIIICHLGNGSSMSAVVDGKCVDTSMGLTPLEGVVMGTRSGSCDPAVVQFIANNDHMTVNEVLTMMNKQSGLMGISGLSSDMRDIDKAADEGNERAALARDMLHYGIKKYIGSYAAAMGGVDIIAFTAGIGENGPELRESVMKDMEWMGAKLDVEKNKVRGKEAVISTDDSKVTICVIPTNEEIMIARDTKELVEGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBZ2</accession>
    <name>R7IBZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49016">
        <property type="protein sequence ID" value="CDE49016"/>
        <property type="gene ID" value="BN770_01892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436362" evidence="2">
        <location>
            <begin position="24"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="756" mass="78542" checksum="333ED47150A286A6" modified="2013-07-24" version="1">MKTTQRIGAMLLISSMLLTGVSVAEEPSNPPAATEALVTAAPTEAPTATPAQEQPTEQSADVPTATPAPENPTEAPTATPAPENPTDEPTATPAPENPTDAPTATPDPENPTDAPSATPAPENPTEAPTATPDPENPTDVPTATPGPENPTDEPTATPDPENPTDEPTATPDPENPTDEPTATPEIPTCDVEGCAHISQDENGLDYPLCRYGRYLLDEEDAYSVATLSNDLRIVDLNRADVTFYRSGQYALIGDRKGATVRVVKNRAAILELRGASIDTLTVEANAVVYIRAADNSLASIKKLEVASGAAVIFSEGGAISIGTVNSKGDISVEGTNLFADLTEMNGRARYAFSASGVQSVLVEGERYAWAVTPDADGKLYLWLKRPGEGMQWTATVTEGTMTLRQTAKAPSGESGSITSGERNTLKSGTVYTLSGDIAEGTVLEIMESGVTVILDGTTSAGTLIEAGAPYDLIVRGDTILDGRGQMPLMGSAPKITVDGLLSVQGQLPNGTKVLSGVVICSDAPDGYTAWAISVPLARQKVTLDGTAMPLLMTPAGELLLPALADDATYSISADADTIVIETVHAQVLTFNLSENAPNADAGDASRFIVNGQNGYLDGAIHSSGAAASATLRNVQLNSASSVLRVENGALSATLTGSCALLSDGAPIALDNAQVSLNVESGRLVLRNQNDLTGITLRGNVRVEPESDAPHTVVTIRDAQGNPVPNKALTVVIGGSQYRYTTHFDGTLQLWGFGDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC43</accession>
    <name>R7IC43_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000122">
        <property type="protein sequence ID" value="CDE48858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48858">
        <property type="protein sequence ID" value="CDE48858"/>
        <property type="gene ID" value="BN770_01842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06325">
        <property type="entry name" value="PBP1_ABC_unchar_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436367" evidence="1">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="321" mass="33815" checksum="4193D010891986D4" modified="2013-07-24" version="1">MKKLTALLTALFLLLSATALADEVIHIGIIQFAEHGSLDNCRIGFIEGLAEEGFVEGENVVFDVQNAQADTAISAQIADVMAGKYDMICAIATPAAMAAFNAAEDAGIPVIYTAVSDPVSAMLAGADGKNPGNITGTSDALPVEAQLKLIRALMPDATKIGILHTTSETNSDATLALYKELAPNYGFEIIDKGISTGADLPMALDALLPQVDCTTNLTDNTVVSYLAVVLEKSEEYGKPVFGSEIEQVINGCVASEGIEYTELGRQTGRMAARVLRGESAEDIPYETISNSYLYVNPDALAAYGLTVPAELSERAIDVTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICA6</accession>
    <name>R7ICA6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48137">
        <property type="protein sequence ID" value="CDE48137"/>
        <property type="gene ID" value="BN770_01552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="53" mass="6000" checksum="3DAC219A6924B250" modified="2013-07-24" version="1">MTTQEALLQAIETALASECAVMPEMQKHIRDTFGALDDHNCERNHQAIRELMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICP3</accession>
    <name>R7ICP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49380">
        <property type="protein sequence ID" value="CDE49380"/>
        <property type="gene ID" value="BN770_01990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="387" mass="42724" checksum="66DC1019B5645397" modified="2013-07-24" version="1">MPTTPAKNLLYRAALPILAPRSRGQMTHHVFGHPLTTLPNYERILAKHHVFGASLLLQDGANCALCDTSTANPEHLAQENTLYRVASITKMATALVTLRCIDNGLFALDSEAASLLPDGEKAPALSGVTVRHLLCHTSGLRDLPILDDCLKEGKPYTELLRQPEIRACAPGQQLIYSNFGFGLLGCILEQQTGLCIEPLFQEMLFRPLHMRATLDASTLNEAEIMPITRVLPYRAGQELRVTALGRHPLQKLNPLCHYGHTAGAMYTDGRSVLQMLTLIHQRGTMDEVRFISESLMREMTRRQSAAPTRTYGLGLVILNRPEISPRQLLGHQGFAYGCVDGAFIEEKTGRAVVFLNGGASEARTGRLGLVNRDVLQWALKQEMPSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICS3</accession>
    <name>R7ICS3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000095">
        <property type="protein sequence ID" value="CDE48307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48307">
        <property type="protein sequence ID" value="CDE48307"/>
        <property type="gene ID" value="BN770_01634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="399" mass="43840" checksum="C494586A3262D4DA" modified="2013-07-24" version="1">MTPLYAGLMCTLLLTGTVAGLFGCMSAVRCHRPFVFAICLTIVSLDFAALAMLLSRLPESAALSPSPWTAAALLLTVLSLSSLLLLRRKSRRQLSPVSIKESCDHLPSALCFAWENGLPCLKNLKMDELSHLLTGEALLNANVFWKAIESQPIVTLENGQTWSFERVQMEMAGKSIYQITGTNITEEARLQREVEKDNLRLKGMNRRLRQYGQDVQEATREKEILRAKTRVHDQIGRALLQTRQFLSGAQGDAESVCAAWRQNVRLLLGKYADEQPVDTFDQLARAARAIGVTIERRGVFPAEDTESAQLVEIAAHECLTNLVRHAGGTRLEIIGGKTASGWRVRYLNDGSTPAGPIVEGSGLTALRARVEAAGGAMEIAHAPRFELTLTFFEGRQGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICX1</accession>
    <name>R7ICX1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48387">
        <property type="protein sequence ID" value="CDE48387"/>
        <property type="gene ID" value="BN770_01678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="162" mass="18509" checksum="3A32483BD073C8B6" modified="2013-07-24" version="1">MKEIMLDFGAILSDLFHALRSGAKKVLIALAVLTALLTALVLYLMTPHTEIRSLTGFRCYFVPRCEVNYQSYHRDDDLYNMGIYKLNGQDAARFVYWAQENGWSKMPLTGEALTSGMLNEETCPEAAEIKQVTQGFWKGFHGSYLYVFDSQTATLYIRKMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID84</accession>
    <name>R7ID84_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000112">
        <property type="protein sequence ID" value="CDE48542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48542">
        <property type="protein sequence ID" value="CDE48542"/>
        <property type="gene ID" value="BN770_00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="71" mass="7580" checksum="4520AACBA3B550E8" modified="2013-07-24" version="1">MPPSYLSVVSGRQPVPKFTKDGFLVKSAAHVSTRRPEGFTSPFRISPSAVMPFEPVKPIHTAASILSAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDS5</accession>
    <name>R7IDS5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP phosphoribosyltransferase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisZ</name>
        <name evidence="8" type="ORF">BN770_02211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49979">
        <property type="protein sequence ID" value="CDE49979"/>
        <property type="gene ID" value="BN770_02211"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00443">
        <property type="entry name" value="hisZ_biosyn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="24"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="403" mass="44026" checksum="3206A5B04FCD2BFF" modified="2013-07-24" version="1">MERRRLQIPSGMQDTLPGECAGKRRLEDKLRRLFTLGGYQEIETPILEYYDALDDQTFGYRPEQVWKTFDPQARILAVRPDSTIPAVRLASGRLKNAPLPLRLCYVQSAAKFHSETLSLLCEDTQAGVELMGEGSAQADAEVIALAVEALRAAGIRDFLIELGQVKFVSGFLEEAGLTEQQCAALRDMMAHKNALDMQLYLDRLSIEADVSRRLMRLPQLFGDAAVLDEAEQLTKSPKCLGAIAHLRQVLSILQDYGCADCVSIDLGLTQQANYYSGVVFHGLAAELGQPLLSGGRYDGLPAQFGRPMPATGFALSLKLTLMALERQGETFAPPVPDVILSFAPGGLRSAIAYAHQLRDKGVSVALLYGLTAEELHQRVDSGEASAAVYLNGSVFEQYGKAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE17</accession>
    <name>R7IE17_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ORF">BN770_02169</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000153">
        <property type="protein sequence ID" value="CDE49860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49860">
        <property type="protein sequence ID" value="CDE49860"/>
        <property type="gene ID" value="BN770_02169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="91"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="285" mass="31362" checksum="66934880C8CC12D3" modified="2013-07-24" version="1">MTTFLQTVETFFWSVLNRPGLSDIADILIVAIIIYELLMLTRDTRGSAVLKGLAMLLLIVGISNLFGLTALNWLLMSVVNNGALVLVILFQPELRKALEQIGRGARIETKRRDTDKDEATRIIDEIIRCLQDLSRRHVGALIVFEQKTGLQDIIENGIGIDARITSGLLENIFEPNTPLHDGAVVIRGERVMSAASILTLTEASGISHDLGTRHRAAIGVSETTDAIVLIVSEETGIISMAKGGKLTRHLDAKSLRTILEGIYVRKPHQRLLSMLVRRKGKEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE29</accession>
    <name>R7IE29_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49583">
        <property type="protein sequence ID" value="CDE49583"/>
        <property type="gene ID" value="BN770_02049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF11" evidence="1">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="284" mass="28982" checksum="EA24302DDF32A868" modified="2013-07-24" version="1">MPTTFTNQATLSYNNQSIPSNVVTGVLTEVLSVSKTAIPAAYQNGDTITYAVQLVNSGTAALTGLTLTDNLGAYTPAAGTAAVVPMTYQSDTLRYYRNGILQATPTIAATSPLTVTGLSIPAGGNTTLMYAVKTNQFTPYGAEESVTNTATVTGGGLAAPLTAEATVNADPAPDLSVIKSMCPTTVTEAGALTYTFTLQNRGATATTATDNVSLTDTFTPALTITSVTLNGTALTAGTDYTYDGATFRTLTPLLIPAATYTRNATTGEVTITPGTATLVVTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE59</accession>
    <name>R7IE59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49905">
        <property type="protein sequence ID" value="CDE49905"/>
        <property type="gene ID" value="BN770_02182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="72" mass="8283" checksum="8C946EDA62FC01E0" modified="2013-07-24" version="1">MANGHFLLFILRQREKSAISVRKKHKFQTENKTLHKMFGKTLDSGGKIRYNKVYPNGARCAVWEIGEGEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IER5</accession>
    <name>R7IER5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50279">
        <property type="protein sequence ID" value="CDE50279"/>
        <property type="gene ID" value="BN770_02342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447891" evidence="2">
        <location>
            <begin position="20"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="382"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="585" mass="61699" checksum="833A3145DE111122" modified="2013-07-24" version="1">MKKFLAGLVSLLMLSTAFAEPTITHLGYTAYLGSSNELYLQDPTGTVRVLRYPIADILSITDTVVYCRAQDGKLLSIALDGSQSLIIAEAPTDEQVNALTAKSSYTLTDGVLRSGATIVDTGVLAFCDLADEQTTTAPDELLYLKQNTTNTAALMVRTENVATARTLAILGITAPVLSMTANGENITIVASDHSVTVYNRVALTTTNYPATSELTEKASAIGSELFRYAPAESFGWNVEISTGLPAIEVVTDRGNAYVATATPAPATAVPTATARPTATVRPTATPRPTATATAASEYTRLNYGSKGKAVRKLQNRLSKLGYPVGKVDGVWGDDTQFAVNLFQSAIGYTEHRYASAAMQEKLYSKKAPVYDPYMPLKEGKKGTPVKLMQQRLFDLGYFTTNDVEKEVDGVYGKRTTEAIKLFQTVCGYEEKKITGVADADTLMLLFDEKAPVNPGNVQPTPTSPVVIVTPTPTNVPTATPAPTEAPTATPTPTNAPTAIPEPTEAPTATPAPTDVPTATPAPTEVPTATPAPTEAPTATPAPTEVPTEVPTATPAPTEAPTATPAPTDTVEVITPEPQPSETVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IER6</accession>
    <name>R7IER6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49936">
        <property type="protein sequence ID" value="CDE49936"/>
        <property type="gene ID" value="BN770_02197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="303" mass="33448" checksum="5481263558B56ABB" modified="2013-07-24" version="1">MENVIVTGANGFIGKTLVNALLAKGCRVTALDVRFDDVLADDPRVTCISVLNKDVPALAKEIPAADYHCFFHLAWAGTSGPARADYDVQLSNVKLTCDYIKLCAEVGCKRVVYASSINEMETYEYLQSDDIDPAGGYIYGTGKLAAHLMGETVAKMTGVEFIPVIITNIYGVGEKSARMIYTAIRKLIHKEHCSFTAGYQTYDFIYITDAINAIIAVAEKGKPFNRYYIGSGEPKPLREFLLEMRDLVDPAAEIGLGDLPFKGVNVSYDQFDLKKVERDTGYVNQIPFAQGIKMTADYIREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEW9</accession>
    <name>R7IEW9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purD</name>
        <name evidence="10" type="ORF">BN770_02174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CBJB010000154">
        <property type="protein sequence ID" value="CDE49868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49868">
        <property type="protein sequence ID" value="CDE49868"/>
        <property type="gene ID" value="BN770_02174"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="427" mass="45140" checksum="E27C2BCB220F1B4F" modified="2013-07-24" version="1">MKVLIVGGGGREHAIALKIKENPEVTALYAAPGNGGIAQIATCLPFKATDVDGIVRWAAENKVDFVIVAPDDPLCLGMVDALAEQGIPAFGPRKNAAIIEGSKVFSKNLMKKYGIPTAAYETFDDYDAAVKYLQTADMPIVVKADGLALGKGVLICPDRDSAVEAVASMMKEAKFGASGARVVIEEFLTGPEVSVLAFTDGKTVKPMVSSMDHKRALDHDEGLNTGGMGTIAPNPCYTPELARRCMDEIFLPTIAAMNAEGRTFTGCLYFGLMMTPKGPKVIEYNCRFGDPETQVVLPLLKSDLLTIMRATVDGTLADTPVEFASGAACCVVLASGGYPVSYKSGYPISGLDEAGKTATVFHAGTKLVDGQIVTAGGRVLGVTATANTLEAAIDKAYQAADKITFTDMHMRRDIGQRALASRKESHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF88</accession>
    <name>R7IF88_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S-ribosylhomocysteine lyase</fullName>
            <ecNumber evidence="5">4.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">AI-2 synthesis protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Autoinducer-2 production protein LuxS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BN770_02412</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17753"/>
            <dbReference type="ChEBI" id="CHEBI:29484"/>
            <dbReference type="ChEBI" id="CHEBI:58195"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.4.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LuxS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50479">
        <property type="protein sequence ID" value="CDE50479"/>
        <property type="gene ID" value="BN770_02412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043768">
        <property type="term" value="F:S-ribosylhomocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037005">
        <property type="entry name" value="LuxS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003815">
        <property type="entry name" value="S-ribosylhomocysteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35799">
        <property type="entry name" value="PTHR35799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02664">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01487">
        <property type="entry name" value="LUXSPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0071">Autoinducer synthesis</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE50479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="154" mass="17030" checksum="335771C151AC0013" modified="2013-07-24" version="1">MLKKIASFTINHDTLTPGMYVSRIDGDCVTYDLRLKFPNQGDYVAQPALHTLEHLIATFVRSSTASEQVVYFGPMGCRTGFYLILRDSMSKADALQLVRDAFRFAADFEGEIPGAKKIECGNYLEHDLTGAKQEAAAYCGVLSRCSEAAMVYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFD7</accession>
    <name>R7IFD7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recO</name>
        <name evidence="9" type="ORF">BN770_02254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50053">
        <property type="protein sequence ID" value="CDE50053"/>
        <property type="gene ID" value="BN770_02254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="242" mass="27598" checksum="CD5C6336285E850E" modified="2013-07-24" version="1">MKQTEHTAIVLRYANYRDNDRMLTLFSPTKGRIEALARGCRKPRSPILNASELFALGDFELYERGNHLTVISANLMETFYPLRADFDRLAVGTYLLGVVENVIQPGVPAQETFMLLLHTLSRLTFSEQPWRPLLTGFLLHLSQSEGFVPRLHHCVHCQRRIADGESTWFDLTEGGLVCRDCRLPVHVPISAAQVNWLRTMLTTGSAGWVDSPEMMAPYRLMRQYVELRLDKPVRSAAMLPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFG2</accession>
    <name>R7IFG2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49297">
        <property type="protein sequence ID" value="CDE49297"/>
        <property type="gene ID" value="BN770_01963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="308" mass="33521" checksum="38929376FC3F4381" modified="2013-07-24" version="1">MRDAFTRALMREAAKDDRLMLVTGDLGFGVLKPFWETYPEQFVNAGIAEQSMTGLAAGLAKTGRTVLTYSIGNFPTLRCLEQIRNDCAYHSLNVKVVCVGGGFVYGSLGMSHHATEDMAIMRALPGVTVFTPGDPAEVEAIVPVMLKTPGTCYLRLGRGGEPTLHEQPVADWQMPKALTLQTGTDIAILSAGGILTQTVSAGKKLAERGISAEVVSFPCLKPIDTEKIAELTRRFRHIVTVEEHSIVGGFGSAVCEVAAETGNPCRIHRIGMEDVYSTIVGTQQYLRAQYQMDDEAIARRAAQWLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFI2</accession>
    <name>R7IFI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50365">
        <property type="protein sequence ID" value="CDE50365"/>
        <property type="gene ID" value="BN770_00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="51" mass="5299" checksum="868FA88973B3EA41" modified="2013-07-24" version="1">MTKPHHIRRALLIAPTVVAALAAGGMVYLTSCAMAEQPVTAILPTLLGSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFJ8</accession>
    <name>R7IFJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000165">
        <property type="protein sequence ID" value="CDE50221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50221">
        <property type="protein sequence ID" value="CDE50221"/>
        <property type="gene ID" value="BN770_02324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016747">
        <property type="entry name" value="Phosphotransbutyrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019083">
        <property type="entry name" value="UCP019083_VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="161" mass="18430" checksum="9BE9CE4BD1B81D1C" modified="2013-07-24" version="1">MNWKIHLYRAILWLITLSLLLVMFGFSAQEGTQSSSISDKIARPITDSLAQRQGLTGQAYWKLYVQVDFAVRKTAHFLEYTLLGILLTLLLDSYCARWHWLSWAGCTLYAATDEIHQLFVAGRTGKWQDVLVDSSGALAGLLMAMFMLWLIRRRRAKKQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFN6</accession>
    <name>R7IFN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore coat protein CotH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49387">
        <property type="protein sequence ID" value="CDE49387"/>
        <property type="gene ID" value="BN770_01993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447924" evidence="1">
        <location>
            <begin position="22"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="14"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="657" mass="74298" checksum="A2CE940D59806762" modified="2013-07-24" version="1">MWKKFCAALLLMLLLPACALAEVVISEIMTSNGTYENGHAYDWIELHNTGKSTVDISGWYLSDSKKNKMKFQFPQGTKLKAAGYLTVFCTGDDEVDVGKGSEFYATFALSSSGESIYLSDADGNQLQKLKYPQQYGCVSYGTTDDGATYGFFENATRGKKNDATIYSGRVDAPVLDTAGGFYTDSVTVMAHSVLSGAMLRYTTDGSTPTAKSKEFPADGLTIKETTVVRIRAFQPELVPSPTVSATYFINDDPATPIVSLITDEDYLFNKKTGALVKGTGSIPNYDKELEYPINIEYFTGDGMCEINQMGTFTCSGHSARINAQKSIALYARKAYGNDRFAFNPFPTRDYDSYKSILLRAANSDTYATRLRDIVASSLAEGEGILYQDHVVIQVYINGQYWGHYNLREKINKYFIAQYEGVTDEKEIDSIDILARTGTDRFTQNGNNEDWLELADFCKKNDLNDPENLQYVTDRLDVDSLFTHAAYEIILGNVDFTNVRVYRVPGGKWKYLLFDVEACWRNLDKTPLEYYIKPVTAKIQGFRHEPLNALLAVPEMKAKFLTRVAEILEKHFQWPDVEAHFNEVIDVLEPILPRHIARWKNMKLSNWQKNISATEYYARVRPKKIPEMLQKAMKLTDEEVETYFGEVLRLLEETNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFR0</accession>
    <name>R7IFR0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50168">
        <property type="protein sequence ID" value="CDE50168"/>
        <property type="gene ID" value="BN770_02310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="57" mass="6330" checksum="E97DC4C549210AF4" modified="2013-07-24" version="1">MPGKKQRHPLYVLFLLLMLLMLALGVYLLVVGCQQGNPPVPLAPFSPQIIGGFFRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFX4</accession>
    <name>R7IFX4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000165">
        <property type="protein sequence ID" value="CDE50223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50223">
        <property type="protein sequence ID" value="CDE50223"/>
        <property type="gene ID" value="BN770_02326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="136" mass="15315" checksum="7617835E5D3B0A46" modified="2013-07-24" version="1">MIQPIVRDVMFLSCKSQMATAEDLPVARDLADTLRAHAHECVGMAANMIGVRKRIIAVMAGKTVLVMLNPVITDRQIPFAAQEGCLSLDGERPCLRYQQILMEYQDEQLQRHVQRFSGFTAQVIQHEVDHLEGIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG53</accession>
    <name>R7IG53_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="9" type="ORF">BN770_02349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50288">
        <property type="protein sequence ID" value="CDE50288"/>
        <property type="gene ID" value="BN770_02349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="107"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="277" mass="30014" checksum="B9BAB39DEB3E3A4D" modified="2013-07-24" version="1">MNPRALLKATASAFRDAGIPDPEVDAALLLSHVTGQPPLSLRLDMTTVLPDGVLTRFDALVSRRLTRQPLQYLLHTQPFLGRDFYVDERVLIPRPETELLAERAIAALREHPHPVALDLCCGSGALAVSMSLEVPGAQVHAADLSPDALAVTAKNAELLGASVTLHQGDLFAAVPETAFDVIVSNPPYIPSADCLTLQEEVRREPLMALDGGADGLNFYRRIASDAPKFLRPGGVLLLEVGFDQAEAVMALLADFADVQAHEDYQHIPRMIEARKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGT6</accession>
    <name>R7IGT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50805">
        <property type="protein sequence ID" value="CDE50805"/>
        <property type="gene ID" value="BN770_00207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="229" mass="24933" checksum="5E1C3E7045E97018" modified="2013-07-24" version="1">MAWWEAGARILLAILIGLAIGYERERRNKPAGTRTHILVCLGAALIAVMENYVEARVLAINTDVLNTGVAVSMGRISAQVVSGIGFLGAGTIFSSRKKIAGLTTAASLWCAGCLGLVAGMGCYTLALSGCTLVLLTLTIVQRIIPATTIRQVEIQYDHRVETTGYIKAFFAAHSVDVLNVDFHSENSKNERAYTSIYTVRMSARVNLVDLFGPLSEYEHVRAFRIRQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGT7</accession>
    <name>R7IGT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49772">
        <property type="protein sequence ID" value="CDE49772"/>
        <property type="gene ID" value="BN770_02126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="PTHR36452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02453">
        <property type="entry name" value="TIGR02453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="239" mass="28002" checksum="D2FD2AA21EF7EED0" modified="2013-07-24" version="1">MFIGFPEATIQFFLDIRFHNSIDYFEENRARYERDVKAPFEAFIQELAPAMLSIDPQMELRPYRCMARLRRDVRFTKDKSPFRDHLWVLFRHAGEPREGSVMYWFELAPSGMNWGVGTWGENRQMMDILRRRIVADPDGVRNVIKQCHLTEHHMLVGGSSFKRLEVPAGVPDDLKGWYALREVYISPESTAAVDVHSPQLTKRVQEDFLSLSPLYHLLRGAYEAVPPEEVDKMVQKMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH11</accession>
    <name>R7IH11_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51094">
        <property type="protein sequence ID" value="CDE51094"/>
        <property type="gene ID" value="BN770_00023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447965" evidence="1">
        <location>
            <begin position="29"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="66"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="304" mass="33802" checksum="5B9B5F42D3039365" modified="2013-07-24" version="1">MMAWWKRFGRRAATLLLTVLMLLGTAAGEGTDKTVINRINAPDVSADFAFAEDADLLEIIFPQILDCDAAFLRCGGKTMLIDCATSGQAQRILNMFKQLGITHVDKIVNTHPHADHIGGFAELIKEITVDELWLCFPAEETVHCANAIKAAERAGVTVRMFGDGDTLTLGTATMQVWMLDKPEYTRLNDRSAQIMLTFGQRKILFSADLEQKGQNGLIEKVGAEMLKADVLKYPHHGLQALTPEYRAAVSPELAIVTCNQRETEGKKYIRRTALDTVWTVPGFIHLTTDGEMWVCDRIVSDVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH47</accession>
    <name>R7IH47_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000193">
        <property type="protein sequence ID" value="CDE51129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51129">
        <property type="protein sequence ID" value="CDE51129"/>
        <property type="gene ID" value="BN770_00290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="793"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="265"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="827" mass="90486" checksum="1181536308F4046E" modified="2013-07-24" version="1">MSEEKKRNGHEIGEVKWKQVKKNHDDTLGQGEDVVYVIGRVGGEGNDVGAGIEDTFEESGDYLHLNEAELSVLEGLKGMKDDGNIRSITVIVNSANPVSMAFADEEDYGVDAVLWVGSVGQTGLYALGDVLSGAVNPSGSLPDTWWKDNQLDPVQNNFGVYTYEGQENYTYPANANSYNHYVVYQEGVYLGYKYTETRYEDVVLGTPNAGNFQYNNVVAYPFGYGLSYTNFAFSDMQVQKVGEGLKTEYQLTVTVTNTGDKAGKKAVQVYAQKPYTDYDVQNHIEKPAVEFVGFSKTKLLQPGESETVTVSVPEYFLTSYDAYNTGVYILEEGAHYLTIADDAHAAANNILTVKGKTTADGMTADGDASMVYTATYSFDATTYAKAYGTGNDVTSLFAAADVNRYEGSGDNTVTYYSRSNWEGTVTPGAVKLAMTQQLFDDTVLTDSDLPSADGYEWPVFGKQADLQLINMRGVDADDPQWETFMDQLTFDQLAKICANGLRMTIAINEIGKPETVDHNGPSGVTQKYSVGSNGYAVQTNDPDKNMKGTCYPCNGIIAATMNSQLVQEVGELIGEDAMWAGYAGLYGTGLNIHRSPYSGRVFEYYSEDGILTGLIDARETVGIQSKGVYVYNKHFVLNDQENNRAGIGTWCNEQALREIYLRAFELPIIQADAQCVMTAFNRLGAIWAGAYTELLTDWLRGEAGMSGFAVTDMYDGTYMVKVNEIVAGNDLPDNFVGEDISELKDYGPDGAKANPMVAQALRTSAKRVLNTVVNSRGMDGISQYTRVVREATWWQLTLNIAQWALGALTAVAFVLVVLDGKKKGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH79</accession>
    <name>R7IH79_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterial sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49942">
        <property type="protein sequence ID" value="CDE49942"/>
        <property type="gene ID" value="BN770_02203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="35"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="229" mass="26471" checksum="BC9F132590D58254" modified="2013-07-24" version="1">MTEATVQQPATTTREQIWLNHEQVRKEKPVYRALKRVQDVFFSLLALIVLSPLLLIVALAIVIDDPSGSPIFTQVRSGIDGKEFRIHKFRSMCVDAEAKLADLKRSTEMNGPIFKHKDDPRITRVGRFIRKCGIDELPQLWDILVGSMSIVGPRPPLPCEVAAYTDYERQRLYVRPGLTCIWQIQPNRNDVTFDEWMDMDMRYIRDRSFLLDWKLIFGTVWTVFAGTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH87</accession>
    <name>R7IH87_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GyrI-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000198">
        <property type="protein sequence ID" value="CDE51164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51164">
        <property type="protein sequence ID" value="CDE51164"/>
        <property type="gene ID" value="BN770_00307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008319">
        <property type="entry name" value="UCP031644"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031644">
        <property type="entry name" value="UCP031644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GyrI-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="210" mass="24083" checksum="DB02BD410E912020" modified="2013-07-24" version="1">MPFDYKKEYRAFYQPPKVPEIIDVPEMQFVCVSGTGDPNEEGGAYQQALGVLYAVSYTLKMSPRAGHLMDGFFDYVVPPLEGFWQQDGVSGVDYGRKADFRWLSVIRVPDFVTAEDFRWAVETASEKKKLDCSRAELRTIREGLCVQMMHIGAYDDEPASVAQMNAFLRENGYENDFTAERLHHEIYLSDPRKTAAEKRKTVIRHPVRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHG8</accession>
    <name>R7IHG8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000190">
        <property type="protein sequence ID" value="CDE51075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51075">
        <property type="protein sequence ID" value="CDE51075"/>
        <property type="gene ID" value="BN770_00285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="184" mass="19463" checksum="D652AD53E65232AD" modified="2013-07-24" version="1">MEKTASTKNTTYTLVAIALMTAVICVLAPLSLPIGPVPISMATLVLFLSIYVLGWKKATISVCLYILLGLVGVPVFSGFTGGVSKLAGATGGYIVGYIPMVALAGFLMSKSDKWWLHLLAMVAGEVVLYLIGTVWFCVQAGKTASAALAICVYPFIPLDIVKMVIVVLIGPMISSRLKKAHLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHH0</accession>
    <name>R7IHH0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA interferase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PemK/MazF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50047">
        <property type="protein sequence ID" value="CDE50047"/>
        <property type="gene ID" value="BN770_02248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="112" mass="12470" checksum="3A0D8FACC8FA38F4" modified="2013-07-24" version="1">MKRGDVYQANLDPVIGSEQGGIRPVVIIQNDRGNRYSPTVIVVAVTTRRKKPQLPVHVLLTREESGLKEDSIVLTEQVRTLEKTRLTRYLGTVTAQAMKRIDRALGMSIGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHI2</accession>
    <name>R7IHI2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50921">
        <property type="protein sequence ID" value="CDE50921"/>
        <property type="gene ID" value="BN770_00246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="307" mass="34340" checksum="3E70BC6A83D85C45" modified="2013-07-24" version="1">MRVVSLFSGAGGLDFGFIKAGHQILWANDLYRDAVETYQKNIGNHIVCEDISKISTSDIPDCDIVIGGFPCQGFSVANTKRHVDDERNVLYKQLLRVIRDKNPKFFLAENVKGILSIGKGKVFQMILDDFQSIGYNVQYRVLNAADYGVPQTRLRVIIVGVRKDVHFEYKYPSPTNSKDGANGLPRWVSVSDALKDIPDPDLPNNLPNHNYSKYKLSFNGYIGHRPLNPDMPAPTVTARGDDKGGVVILPHPTAARRMSCRELATIQSFPLDYEFQGNRSSVYRQIGNAVPVLLGYAVAKQFNLYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHK4</accession>
    <name>R7IHK4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Signal peptidase I</fullName>
            <ecNumber evidence="4 7">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 7"/>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50946">
        <property type="protein sequence ID" value="CDE50946"/>
        <property type="gene ID" value="BN770_00252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="10">
        <location>
            <begin position="63"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27290" checksum="B16C439F1833B06F" modified="2013-07-24" version="1">MSNLEPEQVKQAESAPSSPENAPESPEKKEESALYYTKWQQRMMKKGYVVTPKVKKPAKQNAMEWIATLVGALLLVLLLKAFVGSPVVVDGNSMYPTLHNGEIMMMSKLHYGTSYFFNQPIVLGGEPERFDVVVCRYPDRGSTNFVKRVVGLPGDTVQISGGYLYVNGVKYTEKFLSARMYSDYGPYIVPEGHYFLMGDNRNNSNDSRSSHVGAVPRNMILGKVEAVLWHQIPSTLDDWGLAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHQ8</accession>
    <name>R7IHQ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50132">
        <property type="protein sequence ID" value="CDE50132"/>
        <property type="gene ID" value="BN770_02294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="29"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="201" mass="22234" checksum="8CDBCDA8A9C42DB5" modified="2013-07-24" version="1">MPSELERFNERMQAFFAPLWPGEEKPLVLGEGCSERPPVMLIGEAPGEQEAMSGRPFVGKAGKNLDGFLTVLQLDREDIYISNVVKIRPTKVSEKGRVSNRTPNREELALFTPYLLEEILLVQPKMLVTLGNTALHALLGAKSTIGACHGQVLTAHVQADKQAGDFPLFALYHPASIIYNQKLKDVYQADLERLHSVLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHU8</accession>
    <name>R7IHU8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vancomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000214">
        <property type="protein sequence ID" value="CDE51349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51349">
        <property type="protein sequence ID" value="CDE51349"/>
        <property type="gene ID" value="BN770_00391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435947" evidence="1">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="329" mass="36330" checksum="EB3E3EB08B5014A3" modified="2013-07-24" version="1">MQHIWKILLTSLLIFALAATACLAEDSEAQYQAYSYTTFSLHRTPSESDRGISVQKKTKILILEWDDAWCKVQVGNKVGYAKPEWLYRVQSLDALHYPLQNLPHRMSGYVEFSQDTLISGGKFKGCTASAGQIACVEAQADGAYLLPVWRGEMQLTDEIGTYHPFADWETAEPGDIIGGFTTFYGDQQGQGKAAAREHNISEGVKRIDGVTVEREETFSFNALCAPYRHSNGYELAPNVSTDGFGYGGGVCQVTTTLYNAALTLPLQIEEWALHSKQGAVYVPQFFDAAVGNYSDFTFVNLLPYGVQIHASAQNGVLTVLFCRAEEDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHV2</accession>
    <name>R7IHV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50167">
        <property type="protein sequence ID" value="CDE50167"/>
        <property type="gene ID" value="BN770_02309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="207" mass="23599" checksum="2790DA4D24A16152" modified="2013-07-24" version="1">MYEKLGQWLSHRNPPNEPIPAADYFASLPRLTTDRLLLRPLTMRDAADMFAYSRDPEVARHVLWDAHKSMADTRGCLRYIISQYHSGAPSSWGIVLRETNRVVGTIGFMSYNDADSVVELGYSLARSCWNGGLMTEALAAVLRECFTALRIHRVEAMHECDNPASGRVMEKCGMRHEGTLRGKVFNKGNFHDVELWAMLREDWDARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHX6</accession>
    <name>R7IHX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51384">
        <property type="protein sequence ID" value="CDE51384"/>
        <property type="gene ID" value="BN770_00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="71" mass="7576" checksum="A81644ADF4A8186E" modified="2013-07-24" version="1">MMPLGMVEIGESGVIGKITGQDEVRQHLAELGFVMGERVTVVSKMGGNLICAVKDSRVALSQSMAMRVLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7II30</accession>
    <name>R7II30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative beta-glucosidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000186">
        <property type="protein sequence ID" value="CDE50983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50983">
        <property type="protein sequence ID" value="CDE50983"/>
        <property type="gene ID" value="BN770_00256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="589" mass="65144" checksum="B4D76970A4D72D80" modified="2013-07-24" version="1">MSNTTFDWTVGDASASEIELGTTITVPVTVKNTGSVAGKEVVQLYASAPYTLGGIEKAHKVLVGFAKTKLLQPGESETVTVSFDPYSAASYDYRDANSNGFSGYELEAGEYTLYVSRNAHESEKAIALKLAADVQIGTDPTTDSEVVNRYTDSENFLDSDWQLDTMLSRADWEGTWPTPQTAQQHAGTDRLYEEIRSEEHNNPTDFDSEEYPWFGEEPTLTLRDLLPSAEAEGYEPVVSYDDERWEELMMGCDEEEMIALINNGAYHTLAMESVGLPATIHGDGPSGFTCFMSKEQVNGTCQYVSEPVMASTWNINLMNELGEAIGEEGTIGDKATGQPYSSIYAPGVNIHRSPFGGRCSEYFSEDPFISGMMGAAEVQGIQSRGVLPTVKHFVANEQETHRSIGGDLSWLSEQALREIYLKPFEYTVKLGETRGIMTSFNRIGTRWTGGDYRLLTEILRNEWGFNGLVICDFNTIPQYMIPRMMFYAGGSLDLATQQSAMWTDCDTSEAGDAIVLMRAVKDVMYALVNSNAMNAEVIGYNPPIWQEYLHWINIGAFTLVGVWLVLAIVRTVRCNKRQKAKIAAANAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7II46</accession>
    <name>R7II46_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000207">
        <property type="protein sequence ID" value="CDE51270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51270">
        <property type="protein sequence ID" value="CDE51270"/>
        <property type="gene ID" value="BN770_00354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447998" evidence="3">
        <location>
            <begin position="26"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="75"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="598" mass="65913" checksum="78F2975F10F32C2B" modified="2013-07-24" version="1">MKKRFLHLFSLMLAVLMLIPCVGSAEEAEAVDNGVMREGLTALEATRLMGNGINLGNTLEACDNNVGIKTNTPLSYETHWGQPKTTQAMIDGMKAAGFDTIRIPVAWMTNATHLYEGDYTIDADYMDRVEEVVCYARKAGMYVIINDHWDGGWYGMFGSESAETRALAMEAYKGMWQQIAERFRDYSDYLIFESANEELGGRFDENSPLYCSDSVVTYLNDDERYALTNEINQTFVDVVRATGGNNATRFLLIAGYSTDINQTCDDRFQMPKDTVDSKLMVSVHYYDPWSYCGASSAVSATKWGKVSDYEYLDQQLEKMTKFTEAGYGVVIGEYGALPCSDGLKDNTLAYHTAFLDACTKYNLTNCLWDCSGLYKRVSQTFADDDILAMYQEKRQANEEGQDYADVQAAAAAEAAAAAAEAPVTFLQDAVVVDDQTALAWIMWNDGSWALTHSVGDTYNADSISEGLVATNAIITGEGKYTVGLDFTGTAQGYSASVAFAAIGISNGEALYPNYLVNIKEVRINGEIYRLKGRAYTTSDDGVCTRVNLYNEWVTSVPKTARLPGGNLAGATPTPINRNDAVIAEIKTIEIDFEYVPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7II92</accession>
    <name>R7II92_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase/prephenate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51514">
        <property type="protein sequence ID" value="CDE51514"/>
        <property type="gene ID" value="BN770_00469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011279">
        <property type="entry name" value="Chorismate_mutase_GmP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01805">
        <property type="entry name" value="CM_mono_grmpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="94" mass="10915" checksum="0E1CFC7B39F0BE53" modified="2013-07-24" version="1">MRELAQIRQELDEIDREMVKLFERRMTLCREVARTKLAQGKPVLDASREAQVLESRAAMLTDASLVEAVQALYREMMALSRQEQEKLLREANHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7III7</accession>
    <name>R7III7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-ribose pyranase</fullName>
            <ecNumber evidence="2">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51445">
        <property type="protein sequence ID" value="CDE51445"/>
        <property type="gene ID" value="BN770_00445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="145" mass="16032" checksum="BE36E95B19FA6DC3" modified="2013-07-24" version="1">MLKGISPLISPELLKVLCEMGHGDEIVLADANFPAESMGQRVVRADGIGAAELLRAILPLFPLDQYDESNFVLMSVVPGDPTVPVIWDEYRATLTAYEPDAKIQTIDRFAYYERAKKAHCIVATGESAQYANILLKKGVIRQHCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIJ0</accession>
    <name>R7IIJ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51604">
        <property type="protein sequence ID" value="CDE51604"/>
        <property type="gene ID" value="BN770_00519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="33969" checksum="B14B3F465203ABDE" modified="2013-07-24" version="1">MTHMTIKKTMLESISRFKSSKGDLLRAQGMTMAVWAACLCPLLFLLYASLRAACLCPLLFLLNASLRPLALLCPLMLIFIALPMRQSTAEAMQLFLSGAPMATVAMLPLNGYWKKVARSLRMTGLMLLWLLPFAALVGLMQYERTELDVGTIWGHLNALGGGAFDQGIIRYVIIMVLMLLFPLFGLMFHSGTRHAYALGDRKLVKGHRWQIVGLWLSGLLFVLPMAVCIVALIAQVSVSAVQFTMQWFENLMDMPSFSMLMPPKWLLAVTAVSAVLMLVTNPMRSLLPAIFLRGVKDEKEQEDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIN7</accession>
    <name>R7IIN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50457">
        <property type="protein sequence ID" value="CDE50457"/>
        <property type="gene ID" value="BN770_02401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="103" mass="11519" checksum="57869566C31F7BC5" modified="2013-07-24" version="1">MDCCNHQCEACHKHKERTPEEMKALINRLNRIEGQVRGIRGMVENSAYCPDILTQVAATSAALNAFTKELLASHIRSCVADDIRAGHDEAIDELVQTLQKLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIX1</accession>
    <name>R7IIX1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51421">
        <property type="protein sequence ID" value="CDE51421"/>
        <property type="gene ID" value="BN770_00428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="228" mass="25448" checksum="63127866E01162D7" modified="2013-07-24" version="1">MYRILLVEDDAALADAITQVLTAWGHEVQKVRDFRHVTEEFAEWKPQIVLMDLMLPFFNGHHWTQELRRITSVPIVYLSSASDNLNIVMAMNMGGDDFIAKPVDPAVLAAKVNAVLRRAYDMPATGNILACGEAVLDLDSAALSIHGQSIPLTRNELIILRTLMEQRGRIVSRETLMTRLWQMDEYVEENTLTVNVNRLRKKLSAAGLPGFIVTKVGSGYAVNQEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ34</accession>
    <name>R7IJ34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51298">
        <property type="protein sequence ID" value="CDE51298"/>
        <property type="gene ID" value="BN770_00365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="313" mass="33648" checksum="3D75B25E4DC3148F" modified="2013-07-24" version="1">MTLLLQYMLMFASVLLLVALGGCFSEHSGVINIGLEGIMVFGALGGALMMKYMPDGTAVVVVILLTTLMAMIFGMLYSLLLAVAAINFKADQTLVGTAMNLLGTAAATVIVKAINIAEDVSNVSSAITYINVKKAFLVDINGFEFNWFMLMAAMLLVISYVLLYKTRFGLRLQACGEHPQAADSVGINVYKMRYAGVMISGVLGGLGGLVYITAGVSEWKFENGVAGFGFLALAVMIFGQWKPLRIALAALLFGLFRSLSNVYTGFDFLAQLNLPSTFYNMLPYIISLLVLALTSSKSRAPKAEGIPYDKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ36</accession>
    <name>R7IJ36_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YqgF HJR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000243">
        <property type="protein sequence ID" value="CDE51759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51759">
        <property type="protein sequence ID" value="CDE51759"/>
        <property type="gene ID" value="BN770_00599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="4">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="239" mass="26643" checksum="98DC30BA94786DC4" modified="2013-07-24" version="1">MNERIIALDIGDARIGVAVSDASRLIATPIDTIYRVGYGPDVRKVVEICQRYDTTQVLSGWPLNMDGTAGFQSEKVKAFCEQLEKAGLSVVYQDERLTTVTATNALIEGNMHRAERKHNVDKVAAAVILQQYLDTCRNQQQQEAAKMEEQDNIIELIDDETGAPIRFQHLATIEHEGELYIALSEADAPEDGQCEVFIMQVAQEEDGTESYIQVEDEAVQQAVFDKFLQLVNEGSSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ60</accession>
    <name>R7IJ60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51789">
        <property type="protein sequence ID" value="CDE51789"/>
        <property type="gene ID" value="BN770_00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035709">
        <property type="entry name" value="YoaB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47328">
        <property type="entry name" value="PTHR47328"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="359" mass="40433" checksum="CB0C187417011FB2" modified="2013-07-24" version="1">MGIQHLDVSKGGYSRVTFSKNLAFFTGHAAPQYQTLKEQAEGILKRYDELFKQFGLKKSNILYTTCFMKNADDEDEFADIYFQWIDPKNPPAGVTVTGLPIQHSPVGDNILMELSFIVATNDSLPIKRYDVTRGCRMVEYDGMAYFTGHVYPKVDTLGEQVAGVLNRYDELFEKFGLKKENVIAANGFIKNMAHYGEIAEPFNAYFGENPPAGVIVEAPPRQNTPFGPKLEIELALFVATGENPQITRRDVVPGMSRVVEYNGIAWFTGHSARPEFKTLATQSEAVMKRYAELFEQFGYKKENILMEYGYVRDIEQVNDYLGARKVFIDPENPPAGVVVQAKPSGDENQLEVQFIVNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJD7</accession>
    <name>R7IJD7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51423">
        <property type="protein sequence ID" value="CDE51423"/>
        <property type="gene ID" value="BN770_00429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="122"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="327" mass="36650" checksum="91CA4FB7D736676A" modified="2013-07-24" version="1">MIRRYLREHLPLAGLLALFAGTFALVLSLYHLPTEPVAYASALCAVMGLIALIWGFVRYRRAHQARAHVLNAPHLLLDELPSPRTLSEADDQAIMQRLLHDIRAAQSDLAAYRQDSTDYFTAWVHQIKTPLSVMRLQLQSEDTPENRAMLAELFQMEQYVTMALSYARLGNPTKDLVLTRVPLDPVIRQAIRDFAPLLIRKKLRLQYEPTAESALTDSKWLLFILHQLLSNAVKYTERGRVSIRVTSAPAIIVADTGIGIAPEDVPRVFEKGYTGYNGRGGQKSTGLGLYLVHQTAEMLHCRVSLSSRIGEGTSVTIDLHQEELGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJF2</accession>
    <name>R7IJF2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ORF">BN770_00443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51443">
        <property type="protein sequence ID" value="CDE51443"/>
        <property type="gene ID" value="BN770_00443"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="313" mass="35210" checksum="C2F914E5797EC812" modified="2013-07-24" version="1">MKKDAKIYVAGHRGMVGSAIVRELERQGYTNIITRTHKELDLTRQEAVEAFFAQEKPAYVFLAAAKVGGIVANQNALADFMYDNMVLEMNVIHAAWQNGCKKLEFLGSSCIYPRMAPQPMKESCLLTSELEKTNEAYALAKISGLKYCEFLNRQYGTDYISVMPTNLYGPNDNYHPTHSHVLPALIRRFHEAKINGAESVTCWGDGSPLREFLYVDDLANLCVFLMNNYSGSETVNAGTGKELTIKELTELVAKVVGYKGEIKWDPTKPNGTPRKLLDVSKATNLGWTYRTELEDGIRLAYEDFLNNPMRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJH1</accession>
    <name>R7IJH1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000223">
        <property type="protein sequence ID" value="CDE51468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51468">
        <property type="protein sequence ID" value="CDE51468"/>
        <property type="gene ID" value="BN770_00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="132" mass="14627" checksum="35637AECBA08AEB3" modified="2013-07-24" version="1">MRRCVETASLLYPGVPQTIIGGFRECDFGDFENKNYAELNGRADYQAWIDSGGELPFPHGESRAQFAARCVTAFEQIRQQDEDCAVVAHGGTLMAIMEKFAVPEGGYFDFQVGNGEGFVMEENGAYRQIAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJT4</accession>
    <name>R7IJT4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serC</name>
        <name evidence="8" type="ORF">BN770_00584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000239">
        <property type="protein sequence ID" value="CDE51721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51721">
        <property type="protein sequence ID" value="CDE51721"/>
        <property type="gene ID" value="BN770_00584"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="4"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="358" mass="39630" checksum="8E6528872EC802F5" modified="2013-07-24" version="1">MERVYNFSPGPSMLAQPVLEKAQKDLMVYGNTGMSVMEMSHRSKMYTDIFDKTVADLRTLMHIGDDYEVLLLQGGATLQFSAIPLNLMVKGKADYVDSGNFAHLAAEEAKRYGEVNIAATSREDNYTYVPDMAAAKFDPDADYVHITQNNTIYGTRFVELPDVKAPLVADASSMILSEPMDVNRYGVIYAGAQKNIGPSGLCVVVVRKDLLGHAKPICPKLMDWKVEADKGSMYNTPNTWGIYLAGLTFDWLLSIGGVEAIYQVNQEKAKLLYDFLDNSKLFKATAQKKYRSLMNVTFVTGDAEKDAAFVKAAAAQGLVNLKGHRTVGGMRASIYNAMPMEGVKKLVEFMKEFERENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJV9</accession>
    <name>R7IJV9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase III PolC-type</fullName>
            <shortName evidence="9">PolIII</shortName>
            <ecNumber evidence="9">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">polC</name>
        <name evidence="11" type="ORF">BN770_00690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DNA polymerase type-C family. PolC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51910">
        <property type="protein sequence ID" value="CDE51910"/>
        <property type="gene ID" value="BN770_00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00356">
        <property type="entry name" value="DNApol_PolC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006308">
        <property type="entry name" value="PolC_gram_pos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044923">
        <property type="entry name" value="PolC_middle_finger_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="938" mass="105103" checksum="7C20481FCEAB08F6" modified="2013-07-24" version="1">MRDYAFGNLVTKLRTELGFSQFQLGKLIGVSDKAVSKWENGNAKPRIATCCRLADILGVSLDELLSAAGYARRTQMESPEDNTEAVLMREEKRIMGRQDSELEKRIELHLRTGMSSADGVASAAQYISRAAEWGHTAIAVTDFGVVQSFPAAFQEAAKKQIKLLPGCEGFMLPSEDSPVEDGYPVMLLATNRIGIIHLNQLISLSHTYCYKGFPCIPRKWIQTHREGLLIGSACDGGEIARSIYEGVSDEALTRIAAFYDYLEIEPVENVTDDPVEQIQLRQEVSDTILLGNETGIPVVAVSNARYLDPEDAVCRAVIRYNTGILDTEPQPLYHFRTTAEMLEAFRFLGKDVAKEIVIDAPRRIANLVDNHLALFPAEGKFCPVLPDAEEHISGEAMIQAHSFYGDSLPPQVEERLRDELAIIDRQESWTIFEIARLTVEQSRRDGYPVGTRGAVGSSLVAWLTGISEINPLPPHYRCTACRYADFAVNAAQYRIGADLPARSCPICGRIMDKDGFAIPFETFFGLNGEKEPDIDLNFSSEEQWKAHEFVREKFGDDHVFRAGTIGMLSERNAEKYTRQYFLDHHLGPESGEAESVKEKLSYAVKTTTGQHTAGLVIVPENRDINEFTPVQFPANDFSAPFATTHYDFFQMHGTLLKMDLLGHDSPTLLHLLTESTGVKLSDIPLNDARVISLFTSPGTLGVTAQQILSETGSYGIPEFSAAFVRHMLIELRPSTVEELIRISGLSHGMDIWIGNARELIASKTAVCADVPALRDDIMKDLIHAGMEREAAYRIMESVRRGRGLSQETADTMRKHGIPEWYIEACRKIKYLFPRAHAAAYVTASLQLAWFKIYYPEAFYKAWFTVHQDDMEGTDLMMNITHLRRALLAVRSDAQKDYSDEESWKAFAEREQRQAVLEIILEMRLRGIDFSAVIPETRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJX5</accession>
    <name>R7IJX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000241">
        <property type="protein sequence ID" value="CDE51736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51736">
        <property type="protein sequence ID" value="CDE51736"/>
        <property type="gene ID" value="BN770_00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025904">
        <property type="entry name" value="Tubulin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13809">
        <property type="entry name" value="Tubulin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="641" mass="71256" checksum="30D2A25CE1D9192B" modified="2013-07-24" version="1">MKRKVFLFGGSGGRMLEALLFMAFAGITPEETLDLVLCDPDGDGMHGAVQLRQELADYQRIWASRTYIGTENPAFQTEINLRTWCDPLPMNAKTLADWTQDEKQDALLCQALFPADTASLDLRQGFHDHPELARVAFAAMLSECENDPDDAMHRTLDEIQSALNAGEEVRAVLAGSLCGGTGAAGIESVAALLQNRFGQNDNFRMGAVLMLPCADGESPARAQAALERISIENALQTVCLIGLPQSAQASGGNDLPRLTDWLGAYCMDVLLHRPTWLTGTFTVQTADGAANWMLFGKGDERYRMAFGGLLKGALLWQRKILPTLEKRLAKGNALKSGWIGWYPHYFRGAAEDIEDVRADAQAIDRLTQVALLYLAGIIRSLPLDLRYASVLEMAREQGREHYDMQIRRAGELAVLRYDAEQNGMQEDNDVHRENADTDPEAAAALERIARMAESIQNEDTVQKTFNRQMGGQAAMKMVLDALEKAESENDRLIRDYAEAIRRIAQAEAVVKPSERFRIDDAKTKLKRMERHKQMAAGMCEMLRHDAQEMRDGQLRFEKPTLISAAPENGLFLQEAMDRLLRGEKEGRKELAAWFPVLVQGGKTADLRRTMKQLGRGAKEKDAPAVQLLLVAMETAMQEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJY7</accession>
    <name>R7IJY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AlwI restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50917">
        <property type="protein sequence ID" value="CDE50917"/>
        <property type="gene ID" value="BN770_00245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="324"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="417" mass="48236" checksum="22C70E3618AF2265" modified="2013-07-24" version="1">MLDKTFVPVKPFSNFKWQWACLTCTEGLNDPVVLLGVLQRMYKLERSHLHFSSSEFAHEMDDLTKDVVNAGLNVDLRSGSRNLIRNSGQYWKAVRLIPKETHGMIELTDFGREVASHQISQAEFAAVTIQTLTLPNTAIMSPAICRDWTSHGLFLTPLKLLLQVIYELNRRSPEQGYIQPIELQKIIVPLSGTRGVTVNDYVNFIMWNRNKEINIDRWPNCCEGANDHRMAREFLLFLTNYGYLLQHKYEGNAFEHYSINPELVDEIYQIISTHNETDDINRVLQVMRESQVISEVERKRVRQTVSRPNQAHFRRDVLAACRCCVITNAEMPEILEAAHIKPFKYNGEDTIANGFAMRVDIHTLFDTGHLRISPDGDIDLSPKARNDYGSAFPKKIFLPDFTNRDFLRWRWENYDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKG0</accession>
    <name>R7IKG0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51976">
        <property type="protein sequence ID" value="CDE51976"/>
        <property type="gene ID" value="BN770_00728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="41" mass="4820" checksum="4521E6C2461C8AEE" modified="2013-07-24" version="1">MMRLLDAVAQARQMRANQVTWQAVVERLLLSLMEEKSKWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKL4</accession>
    <name>R7IKL4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-deoxy-7-phosphoheptulonate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000197">
        <property type="protein sequence ID" value="CDE51157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51157">
        <property type="protein sequence ID" value="CDE51157"/>
        <property type="gene ID" value="BN770_00302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="214" mass="23460" checksum="0AE15690D5E174D1" modified="2013-07-24" version="1">MLRGGAFKPRTSPYSFQGLAYEGLDMLCHAREQTGLPIVTELMSPYDIDTFVEKVDCIQVGARNMQNFDLLKQLGKIRKPILLKRGLSATIEEWLMSAEYIMAGGNEQVILCERGIRTFETYTRNTLDLSAICAVKKLSHLPVIVDPSHSTGKSWMVQPIARAAIAVGADGVMIEVHNDPAHALCDGAQSITPAAFVDVMADIRKIAEAVGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKR4</accession>
    <name>R7IKR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51898">
        <property type="protein sequence ID" value="CDE51898"/>
        <property type="gene ID" value="BN770_00681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024025">
        <property type="entry name" value="SCIFF_rSAM_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03974">
        <property type="entry name" value="rSAM_six_Cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="87"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="460" mass="52589" checksum="2A3072C175AE143E" modified="2013-07-24" version="1">MIHTFKAVGQPMLLDVGSGAVHAIDNMAFDVLEMWNDHTPEEIRDALKEKYTAQELDEVIGELKQLEELGALNAPDNYDDVKQVTEPGVVKSMCLHAAHDCNLRCKYCFAATGDFCMGERKLLPFEVGKAAIDWLVAHSGKRVNLELDFFGGEPLMNFPVVKRLVEYGRSIEKEKNKHFKFTMTTNCVLMNDEIMDFLNKEMSNVVISIDGRREVHDRMRPTINGKGSYDIIMNKAQEFVRRRNACDKEYYVRGTFTGFNKDFGNDVLHLADQGFDQISVEPVVTDPKCEYALREEDLPEIREEYERLAQIYMDRRANGKWFNFFHFMVDLEGGPCLRKRLTGCGAGNEYVAVTPDGDIYPCHQFVGRDGYRMGSVLDGTFDRDIQAKFAHNTVLNKEKCRDCWARFFCSGGCAANAEAFHGDISQPYDMECQMERKRLECAMAIYAKERAVRMAKETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKY6</accession>
    <name>R7IKY6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">BN770_00349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000207">
        <property type="protein sequence ID" value="CDE51262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51262">
        <property type="protein sequence ID" value="CDE51262"/>
        <property type="gene ID" value="BN770_00349"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="360" mass="39245" checksum="D6B8CF9B2C30DAD0" modified="2013-07-24" version="1">MKGYLLLANGQLYEGMLMGAAKPVMAELVFTTAMTGYLETLTDPSYEGEIVIQTFPTIGNYGVIPEDFESPRPRLSAYIVRELCDEPSNFRCQGKLDDYLKAQGIPCLTGVDTRALTRVIRNAGVMNAALLTEKPENPEEICAQLKVLPFHPSIQDVTCDGVQPAKKRGIHNVVLWDFGAKANIQRELEKRGCAVTVVPASATAQEILNLNPDGLMLSNGPGDPADNTAVIANLRELMRHRIPTFGICLGHQLLALSQGAKTAKLKYGHRGANQPAKDVKTGLSYMTSQNHGYAVDCDTLPENASLRFVNGNDGTCEGVDYTDMPAFSVQFHPEACGGPLDTRFLFDRFIAMMGGNKECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I2R0</accession>
    <name>R7I2R0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46189">
        <property type="protein sequence ID" value="CDE46189"/>
        <property type="gene ID" value="BN770_00770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="169" mass="19470" checksum="9BF59C875BE73AA5" modified="2013-07-24" version="1">MKPLLIVDGYNVIGAWSEAEKKGWSLDESRDRLMRQLEDYAGFSGEEILLVFDGYQSERTTTTEEKHGNLTLVFTRHGETADSYIERAAAQTPRYRELRVATSDGLEQSQVLSSGAIRMTSRELLRELREMRKSGMSAHQNQPNMNRNTIFSRMPEDIRARLEKLRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3E2</accession>
    <name>R7I3E2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FolC bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000014">
        <property type="protein sequence ID" value="CDE46419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46419">
        <property type="protein sequence ID" value="CDE46419"/>
        <property type="gene ID" value="BN770_00859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="7">
        <location>
            <begin position="44"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="6">
        <location>
            <begin position="295"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="426" mass="46136" checksum="609FEAF35874BEA6" modified="2013-07-24" version="1">MLNSEEIIAAIHGSYATGSKNGFQNVLTLLDKMHVALRTPIVHVAGTNGKGSTCAMLESVLRRAGYHTGLYTSPFLQAYQERIRLDGLPLDDARMVKYGNPLVQAAEEMRAEGAFVTPFEMGTALALAAFDGENCDIAIVEVGMGGRKDPTNIVHPILCAITAIGLDHMAYLGNTLEAIAGEKAGIIKDNTPVVCHPAKEGVRRVFAEAAEKHHAPLRQLSDDTILYAACDAHGATVSYRLSQEWQDVRLNLPGAHQIENAMSVLAMVEELRRQGWTIPDQAVYEGLASTVWPARLEWCGRILIDGAHNPQGVRALRNFVEEQLPNQRRVLLTGVLADKLQEDMLRDFCAIADDIVTVTPDNPRALDAQTYADALCQHGAHAQAAKSLEEGLTEAKRLAGDDAVIVAAGSLYFAGSLRTALGLAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3G5</accession>
    <name>R7I3G5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal-type GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46444">
        <property type="protein sequence ID" value="CDE46444"/>
        <property type="gene ID" value="BN770_00862"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010551">
        <property type="entry name" value="G6P_isomerase_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06560">
        <property type="entry name" value="GPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPI" evidence="7">
        <location>
            <begin position="55"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="261" mass="29252" checksum="4F946CFAA7ECD925" modified="2013-07-24" version="1">MKLDFDPGFDITPLSVDEGFRLGADCFDKGTEFRKLDSVRKSLRDPNCDGPENVYAIMMDVGRKTDLPAMQQRMLLYGVVTYAAGQLGDEPIRSQGHIHKVSAHCGWSTPEVYEIWTGKAVIYMQESGQDDPGRCFAVEAGAGDVVIVPPGWVHATISADPKQPLTFGAWCDRDYGFAYADVRRHGGIAWFPLLTAEGKLRWTPNPAYHTSQLTIKPPRDYSDLGLEKGKSIYRQFEEDPDRFLFVSDPARAANIWKNYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3V6</accession>
    <name>R7I3V6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage IV sporulation protein A</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Coat morphogenetic protein SpoIVA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase. Has a role at an early stage in the morphogenesis of the spore coat.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000006">
        <property type="protein sequence ID" value="CDE46295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46295">
        <property type="protein sequence ID" value="CDE46295"/>
        <property type="gene ID" value="BN770_00822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014201">
        <property type="entry name" value="Spore_IV_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09547">
        <property type="entry name" value="Spore_IV_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007466">
        <property type="entry name" value="SpoIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02836">
        <property type="entry name" value="spore_IV_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="494" mass="54465" checksum="E3122C854FD49A33" modified="2013-07-24" version="1">MESATFDLYRDIAERTDGDVYLGVVGPVRTGKSTFITRLMELLVMPKIPEGARKERIADELPQSGSGRTIMTTQPQFVPSEAVTVSLSDNAPVRVRLVDSVGYMVRGALGSVDKTGSRMVHTPWYDHDIPFEQAAEVGTRKVMTDHATIGVVVTTDGTIAELPRSAYIEAENRVVSELKALGKPFVIILNSAVPNSPDAQTLRTDLQEAYGVPVMLMSVKDMQSADVQKVLESVLLEFPVRQVRLSVPKWLEALDEGHYLVQEVLAGLKKAGQETHRMRETNLLTPAFASCSELDGVQLEQLRPGEGRIDLSLTMKDGMFNRILGEECGTEIHGDKHLLRLMKELVAAKTEYDQIAGALKSVRETGYGLVSPTMAEMTMEAPEIVRQGGQFGIRLKAHAPSLHLIRVDIETEVTPTVGTEEQSEELARQMSNELESDPQKMWAMSFFGKPLSDMVREGLNGKLMRMPADAQEKVQETLTRIINDGDGGMICILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Q7</accession>
    <name>R7I4Q7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46471">
        <property type="protein sequence ID" value="CDE46471"/>
        <property type="gene ID" value="BN770_00883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="366" mass="40413" checksum="5E55099521C99E79" modified="2013-07-24" version="1">MKNRTFQRLFPLLRMGSILLAAVLFCAALIGVNAQLTVGTNEERNLATYLGLALTAVVTYLLQDVPKMLVGRHFGWKLVRYEAFGRVYQADGTGAFVRIQAPAQSRLRYQPYLLPPEDASRHDVTLYMLCPLLYGGTLAVVFGVLTLLTLGQPVSLVLCELAMGGVVLVMTCILPMDERFIASPMAIARMLRDPEQLAEWLYFARMKANGGVEVTDVSIENIPKPATVKTCQDAICVFQRAQIALMVQCDAQKAYGLMKQVLESEARLSYTAWKLLLSDGVVAELLAGEPGEFTALYRGKAGAAIRQVMFRMVDYALPAYAVTTLVTHEAREAEVVRNTLAPVREKMPELDALMKAIEEKAARIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Z9</accession>
    <name>R7I4Z9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplS</name>
        <name evidence="8" type="ORF">BN770_00823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000007">
        <property type="protein sequence ID" value="CDE46308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46308">
        <property type="protein sequence ID" value="CDE46308"/>
        <property type="gene ID" value="BN770_00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="116" mass="13056" checksum="F07440DF0B93B906" modified="2013-07-24" version="1">MSEIIRSIEAKQLRTDIPAIAVGDTVKVMVKVVEGKTERLQAFEGVVIAKRNGGIRETFTVRRVSYGIGVERTFPVHSPRLGSITIIRHGKVRRAKLYYLRSLQGRAAKIKEVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I575</accession>
    <name>R7I575_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46646">
        <property type="protein sequence ID" value="CDE46646"/>
        <property type="gene ID" value="BN770_00969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="10">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="8">
        <location>
            <begin position="191"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="9">
        <location>
            <begin position="276"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="578" mass="65054" checksum="05C2338CB2A634F0" modified="2013-07-24" version="1">MLAPQSNASRTILDFSGVWDFRLKPDAPWQSIAVPASYNDQSADPEFRRHVGLAWYRRSITVPSLLKGQRLMLRFDAVTHNARVFLDGQLLCTHRGGFLPFEADVTNLLYPGQTALLEVEVDNTISHHTLPVGNEGGTAFFGSDNPGIPSVEAGKQHQHEQGINLPNFDFFNYAGLNRPVRLYTTPADYIADVTLVSSMDGTVRYTIVTHGEGDVTLDVLDADGQVVASGTGASGEVHVANPHLWEPAPGVPYLYTARVRFAQDEYSQPFGIREIKVDGCRFLINGKPFHFHGPCKHEDSFFHGRGLDQCLNVTDISLFHWLHANAFRTSHYPYSEEMLSLCDREGIVVIAETPAVGIGEGGKDPYRWAPADYHAQVLTDMIARDKNHPCIVLWSLGNEPNTDAHPQSAYDYWHPLYLLAHQLDPQNRPVTLVGCQNDYTRDITIPSMDVVCINRYYGWYNLSGDLEAAAFAMRMEMDYWATVNKPTILSEYGADTIAGMHGTEMFTEEFQVDYYKTINACLDERPFVVGETPWNFADFGTQQGPMRAGGNRKGLFTRDRKPKMAAHYFRQRWENFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5D8</accession>
    <name>R7I5D8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46473">
        <property type="protein sequence ID" value="CDE46473"/>
        <property type="gene ID" value="BN770_00885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAGPA" evidence="2">
        <location>
            <begin position="134"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="313" mass="33325" checksum="96829C79697D6037" modified="2013-07-24" version="1">MKRHFANMVFALILIAYTVYAALDTFVIVRVLTPDTLPTATAEASTAPTEAPTAVPTATESPAEQATTAPISTDTEYHDDQIDIVLTTMRVENTTVYVADVQLADISLLKTALAGNTYARNLTETTSVQAANAGAILAINGDYYGAQERGYVLRNGVLYRASAQSGTDALVIGADGNFRIITEGETSADTLVREGAWQVLTFGPALVKDGQVTVRSSDEVGRAMTSNPRTAIGQISEGHYLLVVSDGRTKESTGLSLRQLAELMQSLGAQIAYNLDGGGSSTMVFQGRVVNNPTTNGRSIRERSVSDIVYIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5M8</accession>
    <name>R7I5M8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ORF">BN770_01166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000038">
        <property type="protein sequence ID" value="CDE47174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47174">
        <property type="protein sequence ID" value="CDE47174"/>
        <property type="gene ID" value="BN770_01166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="115" mass="13156" checksum="2274C90B75CE199C" modified="2013-07-24" version="1">MARIKRSVNALKKRRKVMKLAKGYWGAKSKQYRAASEQVARSLRYAFKGRKLRKRDFRSLWITRINAAARLNGMSYSTFINGLKKHNITVNRKILADLAVNDAAAFTKLVEIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5P4</accession>
    <name>R7I5P4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell cycle protein FtsW/RodA/SpoVE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46578">
        <property type="protein sequence ID" value="CDE46578"/>
        <property type="gene ID" value="BN770_00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="419" mass="45475" checksum="B8FB6C33FFA4090A" modified="2013-07-24" version="1">MARDRRRGCEKQKDPGRSLSRAVSIFYISAFCLLFLRDYQWQALALAVAVPLASAFTTGFLPRLFPVDKLLLSLTNFLCALGLLVLYDTNPTYAYHQSIYYFVGLAAMVVCIYLIRVGRSFRLLVWPMMLLSLVLLVLPLFIGKETYGAKNWFYVGGISVQPSEIVKLTLIIVISRFMADRRLIPWLGFSVACLGVLMLQADLGTALLYYGVALMLYFASSGNPVLMLCGIGGGVGAALLGYQKFAHVKKRVAIWLDPWSDYDNAGYQLIQSLMAIASGGVLGVGLGLGSPTTIPVYHTDFIFSVICEQFGMLFGSCVLLMYVAIIWRGTSIAMAARTRFHGLLAMGCTAMIGLQTFIIIGGVIKLIPLTGVTMPFVSYGGTSLVACLCLIGLIQGVSSVNEDDLARDADLADYGGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5S0</accession>
    <name>R7I5S0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000030">
        <property type="protein sequence ID" value="CDE46995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46995">
        <property type="protein sequence ID" value="CDE46995"/>
        <property type="gene ID" value="BN770_01096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="187"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="640"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="901" mass="104507" checksum="1D2CE63D21172C90" modified="2013-07-24" version="1">MTNREQKLLPSARQLTSVRRTSNLNSLTGLPERLDFLRQVQQLLTEKKLNGWCVLSIDIEHFKLFNNWYGQVQGDELLHTIGHQLAQLAKENDYIAGYFGGDDFFLCMPDDDKRAQAVYDLIFHCIEDYQQLDSFLPLLGICPVEEHSDDVSVLCNNAQIASGAVRGKLNHRICRFSEQIMQQLEKHQRLLSDVRIGIQRGEFTFYLQPKCNSLTGNIVSMEALVRWHHPEMGLVSPNSFIPLLEETGLVTDLDRYIWESVCRTMSGWIRGGKHFVPISVNVSITDMKAMDVPAHFREMIRRYDLKSELIRVEITETAFAENSNLVREAIDRLHQYGFTVLMDDFGSGYSSLNMLKDTNVDVLKLDMKFIEMNVENRQKGIQIVDSVVNMAHKLNMTIIAEGVETKEQVDMLKTMNCIYGQGYYFYRPLPVKDAERLLSIIVPEDYRDIQRFSGVSPIPAVPSQQWNTTPEIERDVIATLDSAYLLLARLNLNTGECQLLKRTPPLPDTQMPFSRFSNDLVRQRLIHPEDLDDYQRFMALAHLQTEIFSGQRHMDFRFRLSDGKRFNLAELSVLTSRGYTQQEPWVLLCIRRTDDMVNMEADRHYQRELEYYCNCDALTGLFNRMKFEKDVSLLNEEHPDTIECVYIDVVGLHEINNHLGHQTGDSMLCMVAGTARSFFPNDRLYRIGGDEFVILCCNRKHDEVLLAVEKLRMTLRGAEYEISVGVQQGTGQENVQNIVNRAEDAMRRDKEAYYQQNGQERRMRSLNEKLDRLMQEKQDADQFIRVIAPEYIAVYLINFAQDSFRKILIPDFFRDMLDKCNGSFRRAILEYIRLYIAPEDQEEFESLTCAQVVRERLAREGTIDEHYKRSDGMPIHLRIMACDGLNKEESIWIFAKDTEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I645</accession>
    <name>R7I645_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46713">
        <property type="protein sequence ID" value="CDE46713"/>
        <property type="gene ID" value="BN770_01012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="113" mass="13331" checksum="21219B4232AF0ADA" modified="2013-07-24" version="1">MGRRLVRWKAVVILLVVLGIIFYVVMAQSRQRLDALSTRNEQLQQQYAALDQKNRDLREELTYVATDAYIEETARNEFGYVRDGEIHFHFASMDVLRGYTEAEWNALLDEFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6F7</accession>
    <name>R7I6F7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">khpA</name>
        <name evidence="3" type="ORF">BN770_01032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46813">
        <property type="protein sequence ID" value="CDE46813"/>
        <property type="gene ID" value="BN770_01032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9166" checksum="F67F701BDE52C1C0" modified="2013-07-24" version="1">MRELLTFVAQSLVDHPDQVVVRETEGPEAVILELSVAEDDMGKVIGKQGRIAKAIRTVVSAATAKNSKPVFVEIHKPEDDEAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6H0</accession>
    <name>R7I6H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative enzyme of poly-gamma-glutamate biosynthesis (Capsule formation)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46833">
        <property type="protein sequence ID" value="CDE46833"/>
        <property type="gene ID" value="BN770_01041"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025965">
        <property type="entry name" value="FlgD_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13860">
        <property type="entry name" value="FlgD_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PGA_cap" evidence="5">
        <location>
            <begin position="497"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="805" mass="89394" checksum="2B0A216F5225DDB1" modified="2013-07-24" version="1">MNIGNVWRKGLLLGILLLLALVGSAQAEGFQVRVEKDIIGFDENQITVETDQTGLLTLTLSDNYGTYRTITREAKRGTTTFMWDGLGENEERLPSGSYTLHALLVTARGNQETQINVTVGKAKQALLFALRSSDTLYLDTDDWFCEAKPVRTGAVVMDIYAADDLNTKLDTLKKTFGSTTKVSWNGRVKGKKVAEGDYLLRFYAESNPAYVRDVRVTVKEGARPVIPVAETGSIMPTWDMDEAAMWDMMMKPSVVVDIAAVSHQKVYDKPSTNGKALGTLHGQSQGVEVLKVEGGWAYIGAWQHESGGYIEGWVPMKRLKTVTPNSDFGLVVDKQTQRMKVFYRGKCITTLTISTGLAGKNRLIRETAAGAFITVERVSDFEDSGYHYEYAIRYDGGNLIHQLGYKAQRTKKDFSDQEPVLGQKGSHGCVRIPRAVDATGVNVYYLWTHLPYGTRLFILDDPENRALQAAAVSNKVQADVSAPTDVPALSADETELVLTLGGDAVLGTREYWWNDPDSLPTYLNQYGMAYPFSGLQSLFAHDDMTFINLECALKDDGKGEQTGRLWRFRGLPSYTEALWQGSIEQVNIANNHHGDYGTAGEESTRQALIDAGMPFSGYGYTYVWEKNGHKIGFAGCRETTYKNDEFVIARDINRLREQGCDVIVYSCHWGTEYDDKHNALQQEMAYRAVAAGADIVVGNHPHVVQGLTSVGGAVVFYSFGNLMFGGTHDLTTFDAMVAQVRLRFRGKAYVGCEVDVIPILTSGRAAEGVNDFRPVLAEGEDWVRIWEKVQKDTPFTMEEKMYFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R7I739</accession>
    <name>R7I739_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="9" type="ORF">BN770_01196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47276">
        <property type="protein sequence ID" value="CDE47276"/>
        <property type="gene ID" value="BN770_01196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="143"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="536"/>
            <end position="539"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="590" mass="66226" checksum="B6F249C0F8FE2540" modified="2013-07-24" version="1">MQNRTHTCDELRLSDAGKRVQLSGWMDSVRIVSANLAFVILRDFYGTTQVVIDDEEQMKIIRSLNKESVISVTGIVRERDNKNPKIPTGDIEVEPEKIDVLGRCRYNELPFQINRSREADESIRLKYRYLDLRNPDVKKNIVMRCNVVTALRQAMNEHGFLEITTPILTASSPEGARDYLVPARKHPGMFYALPQAPQQFKQLLMTSGFDRYFQIAPCFRDEDARGDRSPGEFYQLDMEMAFATQEDVFSVLEDVLPPIFAKYGTYNTASSAPFKRIAYNDAMERYGSDKPDLRIDLEVQDVTDLIGGCGFQPFEGNTVKAVVVSDMTATRKQIDKLCADVEVVTANKVYWFKLDEKGEIAGGIAKFVKEQKDELVEKLGLKPNTFVGLTCGKKLAAQKTAGVLRRLVADLCPAHIDREKYEFCWIVDFPMYEIGEESGELEFCHNPFSMPNGGLEILQKAAAGEVDPLSITAYQYDLVCNGVELSSGAVRNHDPEIMIEAFKLVRLGEEDVKAKFPAMYNAFCYGAPPHAGIAPGVDRMVMLLAGAETIREVIPFPMNKNAQDVMMGAPGKVDQKQLDELHIACTKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7B7</accession>
    <name>R7I7B7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="7" type="ORF">BN770_01168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000038">
        <property type="protein sequence ID" value="CDE47178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47178">
        <property type="protein sequence ID" value="CDE47178"/>
        <property type="gene ID" value="BN770_01168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="6">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="5">
        <location>
            <begin position="85"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="193" mass="22092" checksum="BA9C5FACDFD73380" modified="2013-07-24" version="1">MDIALDLMINEEIRDREVRLIDENGEQLGVMPTAKAMELAEERGLDLAKIQPTAKPPVCKLLDYDKYRYEQSRRERENRKNQRVVETKEVQLSATIEENDVLTKAKMAQKFLQGGDKVKVSIRFRGRQITHSEIGMKVMQDFAARCAEVSSVERRPMMDGRHMIMILAPKAAKASFAEKKAARENAKGNQEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7J6</accession>
    <name>R7I7J6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA methylase N-4/N-6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46497">
        <property type="protein sequence ID" value="CDE46497"/>
        <property type="gene ID" value="BN770_00906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0680">Restriction system</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="407" mass="46112" checksum="0D65FC465CFE4145" modified="2013-07-24" version="1">MFEAVEISREITGSGQNLLLCGDAYQQQPALSALAGQVQAVYIDPPFMTGETFTRRRRFGTSGWKTGRPMPEYPAYIDRFADTKEYLELLRSLIACAKALLKPTGVLYLHLDWRTSAYARLLCDEIFGEDMFLNEIVWSYESGGRAKKYFSRKHDTILLYARSKDYHFDLRRVPLARAEHRKNHMRRCVDENGRSYSQITTGGKVYRYYDDAPVYPGDVWSDISHLQQKDPERTGYPTQKPLKLLERLLLPVVREGDMVADLCCGSGTAMEAAQSLGCRFVGVDKSPEAILTTASRLECSDLTIDCPCTMDETPLEGEYNGHGGMLLLTGFHAAHPSFPKTEQQLDTLESWSVGKITPEGLQVMQRFRRSRKQPELPWFCVLPEGCGDIAVSTVDAAGRKRVYRWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Q9</accession>
    <name>R7I7Q9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000053">
        <property type="protein sequence ID" value="CDE47536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47536">
        <property type="protein sequence ID" value="CDE47536"/>
        <property type="gene ID" value="BN770_01276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="627"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="709" mass="77447" checksum="04CCEB65C73E85B7" modified="2013-07-24" version="1">MLSNEAIRQQVENLLSQMTLEEKAAQMVQVPYTVVGREEALRWAKLGAGSFLHVLGDDAREVQQAALHSRLGIPVLFGIDAIHGHGLNDHATIFPSQLSCACAWDKDIAREMGEVTAREVATDGLHWTFSPVLCLGRDTRWGRVDETFGEDPYLAGELGEAIVRGYQGDDLSDGEHILACAKHYIGYGEAVGARDACDTEMTYRRLRETFLPPFEKAFRAGCATVMTAYGSIDGTPFTADEKSMKAILRGDAGFDGFSVTDWDNCHSLLTAQHVAADMPEASVLAAKAGNDMMMTSLGFYDAAIDAVRSGKLDEAVLDDAVRHILTVKCRMNLLAQPEKSGRPGCIGCEEHQQAALRAARKSITLLKNDAHTLPLTSVRRVAVIGANADDIRAQYGDWTYFTHPELIPNRPAVRPYVTIREGIEAIGAQENFEVAYHRGCGVLPSDADNIPGAVAACRNADAVVLVVGDVYAQYGETKDRADLALSGRQLELYRELRALGIPLVTVLLSSKPLAIPEIAHSTDALVCAFNGGMFGGQAVAEAIFGRLNPSGRLPISFPHHSGQVPVYYNHLPGWHWGHYSDLPAEPLFTFGEGIGYAPFVYRDLAVDADSLTLSVKVRNAGDIAGEETVQVYLRDCVCEVMQPVKQLIAFRKVLLQPGEEQEVVFHLDRTAFTYINRAEERVFAPGDFMLMAGHSAKDEDLLKETVWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Z0</accession>
    <name>R7I7Z0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol kinase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diacylglycerol/lipid kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47393">
        <property type="protein sequence ID" value="CDE47393"/>
        <property type="gene ID" value="BN770_01238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="287" mass="31193" checksum="1BA78C994BC52F58" modified="2013-07-24" version="1">MRMLIVNPIAGCGYALKVMEQVQSVLTARNLPFRVMRTEYPGYAAKLAREAVEMGCEAVYVIGGDGTFSEAARGLAGSGIPIGLIPAGTGNDFVKTLGTPKEPMAALDFILGHEPRPCDAIDLNGQMFLNVAGAGFDVTVLENVADFGGKIRGLLPYLVGLIRAIWKHQPLKLTYTVNGETRTKDALLCIAANGKWIGGGIPICPDAVPNDGEIDFMVVGHQPRWKVPYYLVRMMMKQILNFPFTEHVLCDKVTVSSPGMHVEVDGEIIACEHAEFTMHPGALMLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8B8</accession>
    <name>R7I8B8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47850">
        <property type="protein sequence ID" value="CDE47850"/>
        <property type="gene ID" value="BN770_01387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="65" mass="6847" checksum="C50D74B0D90A7CA1" modified="2013-07-24" version="1">MCKRSCGERQWVICTGQRALMIAGIVLVAAGLIVLLLCIPAWAWAALLGVALAIAGLVLICVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8E9</accession>
    <name>R7I8E9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47751">
        <property type="protein sequence ID" value="CDE47751"/>
        <property type="gene ID" value="BN770_01338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="1">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="2">
        <location>
            <begin position="372"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="527" mass="60611" checksum="3FD06FE902B2B243" modified="2013-07-24" version="1">MPLDCEVNIEKNAPVRLLNAVMERMDYSKLYAAYSRLGRIEYSPKILLKIMVYGYMRKQISSRALEACCRENLHFIYLLEGQRAPDHNTINRFRKNILTQEAGQDILCQLVVLLHERGLLSLEAAFIDGTKIEANANKYSFVWKKATAQKTEKLLKKIHDELPAKLKEVGIRFHVPEKIAVRQLKKLWKRIHARIKADGIELVSGKGKRKTRLQRLSEWGDQCLAKLKQYTNDIHICGNRNSFSKTDHDATFMHMKEDYMRNGQLKHGYNVNVATCSDFIIGSYISSDRNDVHTLIPFMEQLQKNYEGKNIGSVVVDSGYESEENYCWFEAHPETELYVKPSNHEAAKHRKYRTDISRRENMAYNAQTDTYTCANGKLLQKTQEKKTHTASGLEITTSVYECSECDGCPLKEKCIRACGSKKPLEERHKVIYVSKRFARQRQAMEAKISSPKGCLLQVNRSIQAEGNFAYVKQDLDFRRFLLRGSTKVAAEWLLFSLALNILHLHHKIQNRRLGSGLKIPSSFPAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8F2</accession>
    <name>R7I8F2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47573">
        <property type="protein sequence ID" value="CDE47573"/>
        <property type="gene ID" value="BN770_01288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="92" mass="10073" checksum="42A79465188E4CBA" modified="2013-07-24" version="1">MLNLNMSPMVKGILIGVGVSAVGFYAYKHNEEKVDNFLRSHGVKVKTPTAGFETMSVEDLMRTKESIEDLIAEKEQQEQSVTVEADAAVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8I6</accession>
    <name>R7I8I6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47603">
        <property type="protein sequence ID" value="CDE47603"/>
        <property type="gene ID" value="BN770_01310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010964">
        <property type="entry name" value="M20A_pepV-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01887">
        <property type="entry name" value="dipeptidaselike"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="455" mass="48416" checksum="35D52CB9E2060300" modified="2013-07-24" version="1">MYEKVFAYLDAHAEDYAAQLCRWVEVPSVKGEATPDAPFGKDVRRMLDVAMADAKAFGYETRDFDGYACDITLPGESEEAIAVLGHLDVVPAGDNWATPPFTATRVGDQIFARGTSDDKGPALAALYAMNAIKAAGIPLKKSIRLILGCDEESGWEDMAYYCAHTEMPEVGFSPDASFPIINTEKGMIHGFFTSKLAEDGLQVKQLWTGERVNVIPGESKALIAGGQEVADKVAAYAQKTGLPYTAEVTADGVWVTAEGIPGHSAYPEGRRNAIGMMLVLLREMGVTGALKTLADAVGMEHDGASLGCACSDEISGALTCNMGILHVKDGKVTASLDLRCPVAADLSALTNAIRAHLPGFNVDSLEIKEPHHVPADSKLVRSLLDSYTEVTGEPAAPHATGGGTYAKVLKQGVAYGAAFPEDEDLAHQANEYIRVSQMVKAMKIYAAALMKLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8I9</accession>
    <name>R7I8I9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000072">
        <property type="protein sequence ID" value="CDE47925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47925">
        <property type="protein sequence ID" value="CDE47925"/>
        <property type="gene ID" value="BN770_01437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="227" mass="25834" checksum="3F22C47F915006CC" modified="2013-07-24" version="1">MARRILLVDDEPLMIKGLKRTLEQDGYETDSASDGEEALKKLNSEHYDLVLLDVMLPKLSGIEVCQIVRETSDIPIIMLTAKGEDMDKILGLEYGADDYMTKPFNILEVKARIKSILRRAGANREAPKMELSANGLSINIGSRSATLDGKNVSLTMKEFDLLQLFMKNPGKVYSRDELLETIWGQDYLGDFRTVDVHIRRLREKIERDPANPEYILTKWGVGYYFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8K4</accession>
    <name>R7I8K4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46837">
        <property type="protein sequence ID" value="CDE46837"/>
        <property type="gene ID" value="BN770_01045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="253" mass="28150" checksum="7B67A62F9836FD42" modified="2013-07-24" version="1">MSRLGDLIRTERLRSKMTPKQVARKCGVSESYLLAVEAGTKIIADDQARRILKTIGLREQTEADFSLDDIAATVDLASASPAVAKAVERPKPQPEYELVATTKTAGKKQDDDTDKDENVTGSVWLDALTSVLKRVPIMNAVMQPVDYRLMPIQSGKIEGAKPDKVFYFLAPDDSMRGFRIHSGDLALIVPARSPIDGAIMLVEYNSHRFLRKIKKLNDYSVLLQSYDREYEAVEAQISECSFLGRASKLEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8M5</accession>
    <name>R7I8M5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46862">
        <property type="protein sequence ID" value="CDE46862"/>
        <property type="gene ID" value="BN770_01061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="153" mass="15686" checksum="383185B862AB71F9" modified="2013-07-24" version="1">MNATKKLSAGAWLSIVTCVLSLAALVAYLINTSAAGYFQNATVSNLVLMVVGAAVLEAAAVVLSMVKGAKKVVDLLTGLCQIAAPALLALAFINLVSARVEGFAFIYFSNADVLLEVQTAANMSSATCAIVNLVLLAVSSIAGIVSAFFTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Q5</accession>
    <name>R7I8Q5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000068">
        <property type="protein sequence ID" value="CDE47876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47876">
        <property type="protein sequence ID" value="CDE47876"/>
        <property type="gene ID" value="BN770_00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="211" mass="23817" checksum="CF3E05B372DECAC5" modified="2013-07-24" version="1">MYAKGMTTSDIETHIRDIYGVEVSDTTVSRITDKILPIAKEWQQRPLESIYAVVFMDAIHYHVRSEGQIVKKAVYIAIGIDLDGRKDVLGMWVGENESAKYWATVLNSLKNRGIEDIFIACTDNLTGFSAAIEAVFPKTEIQNCIIHQLRNSSKYVSYKDIKALMADLKAVYAAVDESAALDALDAFAEKWDKKYPKIAQSWRENWANLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8S6</accession>
    <name>R7I8S6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkyl sulfatase and related hydrolases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48254">
        <property type="protein sequence ID" value="CDE48254"/>
        <property type="gene ID" value="BN770_01601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:alkyl sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435616" evidence="5">
        <location>
            <begin position="24"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="6">
        <location>
            <begin position="137"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="673" mass="75196" checksum="2F68564E51F39F83" modified="2013-07-24" version="1">MKKKLLSLLLVPTMLAATLTACASAEKSSNTAAVFNAETKPATQSTMEVNRQVYDFLNFEDTSEFENAERGFITAPDTLNLRGENGRIVWTQDAYAFLDKDAPDTANPSLWRNTQLNHIYGLFEVTDGIYQVRGYDISNITFVRSEHGWIIMDCGSSKYTAAEALKLFRSKMGDARIVAIVISHAHVDHYGGIEGLIAPEDAADSSLPLDEQIASGKTAIIVPKGFTDAVMKENVFVGTAMKRRAFFQYGSMLPYGEQGRLSVGIGLTAVQTGVGYIAPTFEVADSIYETTIDGVTAIFQQTPGTESPAEMNTYFPDSKALWMAENCSGTMHNLYTLRGAEVRDANGWARYITEAQSLFPDAEVVFQAHNWPHWGKETVNEYMTNTAAIYKFIHDQTLLYINEGYTSTEIASMIRLPEELEKVWYTRQYYGTLKHNVKAVYQKYMGWYDANPIHLDELTPSEYAKKLVEYLGDTDKVLEMAHADYEKGEYQWVAQITNTLVFADPENKEARYLCADALEQLGYQAESGAWRNAYLVAAFELRNGTGQYPKAAQLGVGTTAQGMDAQTMLDYMGIIMDTEKLQNRSFTINLKLTDGDDYLLKIHHGVLLYYKDALSDEADLTISTPRIGILAITSGNQENIDKLITVEKGDKALFQVFCDSMAAFDLYFNIIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I927</accession>
    <name>R7I927_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000101">
        <property type="protein sequence ID" value="CDE48379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48379">
        <property type="protein sequence ID" value="CDE48379"/>
        <property type="gene ID" value="BN770_00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="73" mass="8385" checksum="1AC905DEBDEEADDF" modified="2013-07-24" version="1">MMKVPEFQAAMERTGVERKCYTTDEVATMLGISMKSVYQLLKQNAFRSIRLPGGIYRIPKTAFDAWLNAQPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9E8</accession>
    <name>R7I9E8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 type 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47903">
        <property type="protein sequence ID" value="CDE47903"/>
        <property type="gene ID" value="BN770_01420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447714" evidence="2">
        <location>
            <begin position="24"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="404" mass="43635" checksum="E073A80BC66E255D" modified="2013-07-24" version="1">MKRTLKILLCAALTAAICIPVLADVPATSSGLVATSAILSATEHSGETDVTADLLDGNTATAWVRTSAAAPDLSLALSGASVGEIWIRSGYCYNQNYYNSYDRPATVAVTIWYAYGQQSVTYRYTLSDAFLPTTSSADWSNGYQRLLLPEEYTGVTQIDLTIETVYAGRGNAGAAISDIALAADVHATATPRAYTTATPKPYIAYVTPRPSTTPTSTVEWITPTPTGTTAAPTVTKDVDPTPTPTAEPAFPSKGVAAALTKRAATRSGPSNRFDEPGSFYNAGDIVNVISKAWDSENGIWWYQIEFNTSDGWMRAYTPANRVDVSSDSIPTETNLNDTRTVITSGAVYFGPSTTYRKYGWSWIYEGDTAIICQIEGSWAQVEYYSYAKDVTRRGWVKLDTLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9G4</accession>
    <name>R7I9G4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47923">
        <property type="protein sequence ID" value="CDE47923"/>
        <property type="gene ID" value="BN770_01436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="203" mass="21671" checksum="026D717E2CD1B698" modified="2013-07-24" version="1">MSTPPCPKALSASARFMPPTLMPSIVTPGKMRSVLTSATASLKFAIRSASYRMMLPLTNASVGSPASSMPSICGAASSSSPAVHVSEISMTSSHRKVLLRFLRPLRGLGVVFRFGADGRLPVGVPRVLGGALRRASSSISRCERPFGWRMAGWRGFVSGANFSVRRVCWLRRGRCVPPEMLLMSFLQNGFQPLHSGCCGGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9T9</accession>
    <name>R7I9T9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48659">
        <property type="protein sequence ID" value="CDE48659"/>
        <property type="gene ID" value="BN770_01775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010718">
        <property type="entry name" value="DUF1294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06961">
        <property type="entry name" value="DUF1294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="95" mass="11039" checksum="EF97AC6637827885" modified="2013-07-24" version="1">MENWLLNLIWVYLLAVNTLAFSLMGIDKRRAKRGAWRIAERTLFLPVVLFGSLGGTLGMFCFHHKTRHWYFRYGFPILLVVQLLLLGAGAYLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAF7</accession>
    <name>R7IAF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000122">
        <property type="protein sequence ID" value="CDE48874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48874">
        <property type="protein sequence ID" value="CDE48874"/>
        <property type="gene ID" value="BN770_01851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="257" mass="28337" checksum="7DC4F529D2F575E6" modified="2013-07-24" version="1">MLEMKNITKIYNPGTVQETCLFRDFSLTINKGSFVSVVGSNGSGKTSMLNLLCGSIPVDAGQILMDGQDITRVKEFRRYRRMGRVYQNPAMGTCGTMTILQNLSMADNKGKPFGLTPGTNRKKLEAYRAMLAPLGLGLEDKMDVPVGSLSGGQRQTLALLMATMTPIDFLILDEHTAALDPKTAEIVMQLTNKVVQEKHLTTLMVTHNLRHAVEYGDRLLMMHQGHVIMDKAGDEKRALKVDDLLDVFTSISIECGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAH1</accession>
    <name>R7IAH1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YhcN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48590">
        <property type="protein sequence ID" value="CDE48590"/>
        <property type="gene ID" value="BN770_01733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019076">
        <property type="entry name" value="Spore_lipoprot_YhcN/YlaJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09580">
        <property type="entry name" value="Spore_YhcN_YlaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436319" evidence="3">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="191" mass="20648" checksum="11FFBBB8F56F0A1F" modified="2013-07-24" version="1">MKKTHLLLMLALCATLLASCSAGEPDVTQTQPVPSISPTNTPDENTVLPGLDDDIILPDGGMNDSTTREATGVTSMDKARRVIEQLEEELERLSEVKEAHVIIAGHKAAVALTFDDQYKAGIDDRFRKIVRERIDGVIGGIDTVALTTDKTVMDALEALQDRLDSVSDMSSLQAELDKILETMNAASRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAI3</accession>
    <name>R7IAI3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="7" type="ORF">BN770_01743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48600">
        <property type="protein sequence ID" value="CDE48600"/>
        <property type="gene ID" value="BN770_01743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="94" mass="10380" checksum="1EFAB9FDCA244736" modified="2013-07-24" version="1">MMKLNLQLFAHKKGMGSTRNGRDSESKRLGPKRADGQFSQAGNILVRQRGTKIHPGQNVGIGKDDTLFALVSGVVRFERLGRDKKQVSVYPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAK5</accession>
    <name>R7IAK5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000111">
        <property type="protein sequence ID" value="CDE48526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48526">
        <property type="protein sequence ID" value="CDE48526"/>
        <property type="gene ID" value="BN770_01721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040794">
        <property type="entry name" value="CE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17996">
        <property type="entry name" value="CE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CE2_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="137"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="356" mass="40653" checksum="1E602DA60B979FE5" modified="2013-07-24" version="1">MWTQLPGEKRIALDDENLQYTGRIDFADPQNPVFLFTASFVRFRMTGHHLRVVLTNTHHLWENRLGVVINGEQFGVLLDWDTLNVIDLSDHLRDGENDVMLFKRQDSCYKMILHALLIDENATLLPPPARPNRRIEFYGDSVSAGEVSEVTEYAGKIDPPDHQARYNNVWFSYAWQTARLLNAEISDIAQGGIALQDGNGYFFDTGMLSCWDKLAYNPFFHDEKPWDFSRFTPHVVVVAIGQNDSAKRNFMAEDYDGEQAKRWRSDYAGWIRAIRGKYPHAHILLTTTIMAHSPAWDDAIEEVFGKLGDEKVHHFLYPKNGCGTPGHVRANEAAEMAKALAAYIEAIPNVWQEDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAN1</accession>
    <name>R7IAN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YunB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48954">
        <property type="protein sequence ID" value="CDE48954"/>
        <property type="gene ID" value="BN770_01884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014197">
        <property type="entry name" value="Sporulation_prot_YunB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09560">
        <property type="entry name" value="Spore_YunB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021383">
        <property type="entry name" value="YunB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02832">
        <property type="entry name" value="spo_yunB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="231" mass="24619" checksum="9A3F0FFDF5EA0DB2" modified="2013-07-24" version="1">MPQTNNESEAKIPAKRRKSPRRRWKRALWLLPVLLTLLILRVERNVTDVVLTLSQATARSLAIQALNEAASEMLGLGVHYADLMTVEKDEQGQVRLIQANTPEMNRLAAQASLLAQERLTAMGQKTVVVPLGSAIGLTLLAGAGPGIAVQILPVGSVQAAFSTDFTTAGINQTRHRISLVLTANVQIVIPTGAKNVQASTQMAMAESIIVGQVPDSFAEGGSDNSIIDLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAU3</accession>
    <name>R7IAU3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/antitoxin MazE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49019">
        <property type="protein sequence ID" value="CDE49019"/>
        <property type="gene ID" value="BN770_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="81" mass="9033" checksum="EB2C06579B2AB4AC" modified="2013-07-24" version="1">MTVSAITKWGNSQGIRIPKSVMLAAHLCENDEVELIADKETILLRKLRRPQTLDELFAGYEGDYQPMEIDTGADVGLEVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAX9</accession>
    <name>R7IAX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000056">
        <property type="protein sequence ID" value="CDE47657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47657">
        <property type="protein sequence ID" value="CDE47657"/>
        <property type="gene ID" value="BN770_01325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="265" mass="29100" checksum="3CF37F3F1358AD66" modified="2013-07-24" version="1">MAVEITGSGYNSKVKLYNIHQGNGYFRKDTSTTHSQVKLLQSALTDLGYDTQGADGKYGNNTLAAVKKFQEANNLTADGLFGKNSLTALESILGTHLDPENCETASGSVTTANLTVTEYIQNLESYCNSGWKYGSGYNASKKLIDCAWYPYKARSDQGAHGCTTEYNGYLSEKGKISSYDDLKVGMEVFQQSSDDSTKKSHMGVYAGKVLLRGELKHAVYQSCSSHSNIATKYNDGVANDSGPNLTEMKAGRWKYWGWSKYVKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB97</accession>
    <name>R7IB97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YodJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48588">
        <property type="protein sequence ID" value="CDE48588"/>
        <property type="gene ID" value="BN770_01731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435721" evidence="1">
        <location>
            <begin position="28"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="2">
        <location>
            <begin position="99"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="30822" checksum="CF1F059EEB81790F" modified="2013-07-24" version="1">MKQWKKQLSAALCAALLLGCVSMPALAEENEEYDLSDIPGVTIEDPRIDPLEWNFALSLSDLDPELIKLANKECLLSSTYEPSSKTKMKLRAAPGAGTMYLQSECAEALAELFAGAEEAGYKLYLKSAYRAYKTQKTMYNNRLERNNGKDDGWVSKPGASDHQTGLGCDVVPGSWKDKSMNSNMASTPECQWMAEHCYEYGFVIRYPEDKQDITEINYEPWHLRYVGKEVARYIWRNGLCLEEFHEQLQAAIDAYLAAGGDARRVEDLIQTSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBE4</accession>
    <name>R7IBE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47817">
        <property type="protein sequence ID" value="CDE47817"/>
        <property type="gene ID" value="BN770_01378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="58" mass="6737" checksum="90D6634B4477C7EA" modified="2013-07-24" version="1">MSPPKKYIHDLMQMYLIRFSELSCLPIPMAWKGRDFDTFNARSTKCRKSDCKSGVHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBV4</accession>
    <name>R7IBV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47992">
        <property type="protein sequence ID" value="CDE47992"/>
        <property type="gene ID" value="BN770_01476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="130" mass="13999" checksum="6F7A15E79D9EB09F" modified="2013-07-24" version="1">MTLPELLAQSDVLSLHCPLTQETRRLLDRSALARMKQGSILINTARGAIVDCDALADALESGHLRGAGLDVYPDEPHIPPRLIALPQVVLTPHIGTNTQETRQRMAEGCARQIADALAGKRPAHVVNGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBW1</accession>
    <name>R7IBW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48763">
        <property type="protein sequence ID" value="CDE48763"/>
        <property type="gene ID" value="BN770_01815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448141" evidence="1">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="225" mass="23654" checksum="ACCB7C3B46B231F4" modified="2013-07-24" version="1">MKKFFALLLSIMLLSTAALAEVKIGQVEYAAHGTSCFAVLTVAMDGDTIVAAHIDEFQFMDAATAEGVPNSDASFGQNYPEGKVLASKVVNDGLYSTNMTTKAGATTPLGVSYNAIEAFVTGKTIAELEAAIEGKTKEEMVDAVSSSTLVDTLGYVQGLLAAAKAANNQTGYYTVYNKTGETVKEVSITINATGEKFVMATDVPADAMVTYPFSWSSAFSCLISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICK5</accession>
    <name>R7ICK5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Ribosome biogenesis GTPase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49226">
        <property type="protein sequence ID" value="CDE49226"/>
        <property type="gene ID" value="BN770_01946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019991">
        <property type="entry name" value="GTP-bd_ribosome_bgen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03596">
        <property type="entry name" value="GTPase_YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="14"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="128"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="33789" checksum="182BC3A3ECAF182E" modified="2013-07-24" version="1">MDINWYPGHMAKAKRLLADQLSRVDVVVELCDARLPYSSRNPDLDKLLAGKKRVLLLNKADLADPAATSAWLNYFRAQGIDAAPYSASTGKAKDALAVIDRAAKEAVERAAQKGIRKTVKAMVVGVPNVGKSTFTNKLHGGNIAKTGDRPGVTRANQWVRITPYLDLLDTPGLLWPRLDDQLAARRLCYIGTVKDDVVDLAMLTIHLLQDMLKVQPQAVMTRFRFDNPELRGEELLEAVCKGRGFLMKGGVCDYDRCCAVVLDEFRAGKLGRMTLEMPVKKARLTIPGAKKDDESKPQEENSDGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICM1</accession>
    <name>R7ICM1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49639">
        <property type="protein sequence ID" value="CDE49639"/>
        <property type="gene ID" value="BN770_02067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="297" mass="33761" checksum="F75F83BAACF2172C" modified="2013-07-24" version="1">MSEKDFTIMHSRNMQQVSVTQRITKVLTLFITYAFLIVMALIVLFPFYWMIISSLKSLDEYRASVPTFWPRMVLISNYADAFSTGNLGRLFLNTAYVGIVSTMLSLIITILTAFAFARLEFKGKNALFGALLATMMIPGELFTITNYQTIFMLGWQNTYTVLIVPFLVSVFYIYLLRQNFLQIPNELYLAAKVDGTSDFKYLWKVMVPLSLPTLISITILKMMGAWNSYVWPRLVANDDAHKLITNGLRNAFNSSTGETNYPVQMAAVAMVSFPLFLVFIFLRKYIMSGVSRSGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICN9</accession>
    <name>R7ICN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-1 4-xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49654">
        <property type="protein sequence ID" value="CDE49654"/>
        <property type="gene ID" value="BN770_02077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435717" evidence="1">
        <location>
            <begin position="25"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="2">
        <location>
            <begin position="67"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="261" mass="29124" checksum="10665583F7B3DC0B" modified="2013-07-24" version="1">MKKKLAAFLAMMMALVTMSSAAMAEEETPTITAHKANAITIDGDLSDWDLSSPAVLEDASQIIRDLSFWQGPNDLSAKVYAAYDEENLYLAFDVTEDTPYGAIEMLPLDGEDNLKVFISTDPTDDPNRTEYHTNDFLLFLICDNNYFDTAFDRTMVAKEYRQRFISKGIDGGEDVLTEGYERATQATSTGFIFEVKIAWANFANNKIAVYKPQSGDVVKFNVAVTDISYPCPGTEYIPQMAWTGTLEINTNPSLWGNLVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICQ4</accession>
    <name>R7ICQ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01997</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49395">
        <property type="protein sequence ID" value="CDE49395"/>
        <property type="gene ID" value="BN770_01997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="643" mass="71118" checksum="18773A9922217F69" modified="2013-07-24" version="1">MAIVEMKRIDLLAMRQDQRKLLRTLQDMGCVEITPLQDEALAEYRTRDDGRLEQVDALLARLSWVIHECAAYNHQPAPFMGNLPEAPAQDVHYITQQEAALQETLRQAETLEKRSGEYRGQLMRLQVSQSQLKPWLSFDLPMEQMHNTRRVAHFLGTVKAAELQQCQEKWASLPVVVEQLSAEHDTAAVWICAHQSAREQVAADLRDAGFAPAQLPEFTGTAAEQSARLENEKNEILRQQEALVQDWKALSAELTHLKVWYDALTIERDQLEAARQTIGTGKAFLLRGWVPAEVAQQVADKCRSLAPTCSVDITDPAEGDEPPVLLDNNRVNAPYESVVEGFALPAYRSVDPTAVMAPFYACLFGMMLSDAGYGLVMIVGILALIFLKKPAKKNARLLWVLFGGAVMTVVWGAAYNTWMGFTAPWGGLLDPMNDPMPVMMICLAVGVIHLYAGLGMAAYLNFKRGKPLDALYDQFSWIFALTGLGLYALCGGTLKMIGLGLTIFGVALLLLFGGREKKNPFARLLGGLSQIYGATSWISDILSYMRLFGMGLATGVMGQVIDMLVGMIFQNGPIGWILGSVLFVGAHAFSLGINALGAYVHACRLQYIEFFGKFFEEGGVAFRPLQRRTKYVSIRPETGNKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICU5</accession>
    <name>R7ICU5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49709">
        <property type="protein sequence ID" value="CDE49709"/>
        <property type="gene ID" value="BN770_02095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012427">
        <property type="entry name" value="DUF1622"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38468">
        <property type="entry name" value="PTHR38468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07784">
        <property type="entry name" value="DUF1622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="130" mass="14535" checksum="E382E9191193DF0A" modified="2013-07-24" version="1">MDTIISFLEKLVHYSAELGIVLAELAGIAILIITAVKGVVSYFKHNEHLRLELAQGIALALEFKLGGEVLRTVIVREWTELLILGAVIALRGVLTLLLHWEIKVEEEHDERLLKLKAMEEAEKTAETSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICU6</accession>
    <name>R7ICU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin autolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000097">
        <property type="protein sequence ID" value="CDE48342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48342">
        <property type="protein sequence ID" value="CDE48342"/>
        <property type="gene ID" value="BN770_01664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="201" mass="21907" checksum="32C5CD03981C1429" modified="2013-07-24" version="1">MSLTRSLLKELQISPDAAERIIAAHAESIDALRQERDAARGEAAQLESIRAALAEMTQARDEACQARDSAREELSALGGQFDSYRQQVETEKHQQARHANLRAALQSAGANPHALDLLLLALHPDESAFDGDEITDPDALLTPLKAQYGAFFAQPTRLPTDVVSPPVTAAPPLTKEDVRRMSQEDINRNWSSVCSVLSKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID33</accession>
    <name>R7ID33_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator CdaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49331">
        <property type="protein sequence ID" value="CDE49331"/>
        <property type="gene ID" value="BN770_01978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="281"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="349" mass="40289" checksum="0207B6FFBAB12FFB" modified="2013-07-24" version="1">MNKRLQEQVDNVLNRLSVPITILDADSDRLPDGMPLSTLRLTEGEARTMLGSLYMAVPPLHIVLTCAEQQPGARDVLQLAAMLIAALDHSGENRTESSSDVYCRALRGDLMGSELEALSHEHQLPQEMDRTVMLFHIVQTENECAYDLLRDITPVQDKDVLLNMDRHTVVLIKEMTDVETIDDLHQFAQALQETLMGETAHQMTVGIGKMRRTIDELRDSYNEARRAIEVGRIFKPEESIYIYSRLILERFLMELPQDISAYYHGLLFNRKNQRLFNEEMLYTIEMFFKKDLNLSDTARQLYIHRNTLVYRLDKVQRQTGLDLRSFDDAITFKILMELKKVSGDKAPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID35</accession>
    <name>R7ID35_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48477">
        <property type="protein sequence ID" value="CDE48477"/>
        <property type="gene ID" value="BN770_01715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="210" mass="23679" checksum="5FFDAB781AE322EB" modified="2013-07-24" version="1">MKSLFSKEKWQQLFYTVSHPSDGFYWIRHGEKGSVAIAILMVVLFGLCFTLNRLLAGFVVNDINERTVNALWEMTGVLMLYLLLCVGNWSITCLMDGEGRLKDIAIAIGYSLLPMIVCYIAATIVSQFVAENEEAFYAIIIFLGTAYTLIMALIGIMQVHNYTLGKTLLTLLLTLVAVFIIIFLMMLIANFIGQVFGFVRSIYTELIFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID70</accession>
    <name>R7ID70_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">BN770_01995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49391">
        <property type="protein sequence ID" value="CDE49391"/>
        <property type="gene ID" value="BN770_01995"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="209" mass="23086" checksum="163ED803A3311288" modified="2013-07-24" version="1">MSQVHVLNHPLIQHKLTIMRKKETGPKEFRELLEEISTLMVYEVTRDLPTEEVEIETPICKMKSKVLAGKKLGIVPILRAGLGMVDGVTNLIPACRVGHIGLYRDPVTLNPVEYYCKLPADAQERELIVLDPMLATGGSASAAISFIKKRGCSHIRLVNLIAAPEGIKRMQEDHPDVDIYVAGMDDHLNEHGYIVPGLGDAGDRLFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDA3</accession>
    <name>R7IDA3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49779">
        <property type="protein sequence ID" value="CDE49779"/>
        <property type="gene ID" value="BN770_02130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="314" mass="32797" checksum="673427ADB5DFB6B2" modified="2013-07-24" version="1">MIYVGIDVGGTGIQVGLVDESGKILCKGGIVTRTDIPFDMQVKAMADCVLDTIDKGGYTLGDVKAIGAGVPGVTDPRTGNIAFCTNLGWVDVPFVQEFNKHIAKPVFVGNDATVAGLAESVAGVSAGSDSSVFITLGTGVGGGIVFNGKVWNGFHGVGSEIGHMILELDGEPCTCGNYGCVERYCSATAIIRMARELCAVHPESEIVKVCEGDLNRVNAKVVFDAAKNGDEIALKVFHRYVKYLGQLVASLVNCIDPEVIVLGGGVSKAGDFLLDAVRAEARRYVLYKTLPSARIELAKLGPDAGIIGAAMLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDC3</accession>
    <name>R7IDC3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49446">
        <property type="protein sequence ID" value="CDE49446"/>
        <property type="gene ID" value="BN770_02023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="454" mass="50308" checksum="655B0D2588F825B2" modified="2013-07-24" version="1">MYDVLIIGAGPGGIFTAYELMERRPDLKVAVFETGHPLNRRKCPIDGEKVKSCIHCKCCSIMSGFGGAGAFSDGKYNITNDFGGTLYEYIGKKAATELMEYVDTINLRYGGEGTKLYSTAGTSLKKTCMQHGLHLLDASVRHLGTDINYIVLEHLYDYLKEQVEFHFDCPIDTVEKTDNGYRIYSGDKFFEGRKCVISAGRSGSKWMEKVCKDLHIKTNSNRVDIGVRVELPAEIFSHLTDELYESKIVYRTEKYEDAVRTFCMNPRGVVVNENTNGIVTVNGHSYEDPAKQTNNTNFALLVAKHFSEPFKDSNGYGESIARLSNMLGGGVIVQRFGDLIRGKRSTEKRIKESFTVPTLNAAAGDLSLVLPKRILDGIIEMIYALDKVAPGTANDDTLLYGVEVKFYNMEVEVDSNLMTCHDGLYIIGDSSGITHSLSHASASGVHVARQISKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDD4</accession>
    <name>R7IDD4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="8">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nadD</name>
        <name evidence="10" type="ORF">BN770_02074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 8">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49650">
        <property type="protein sequence ID" value="CDE49650"/>
        <property type="gene ID" value="BN770_02074"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008803">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00488">
        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="9">
        <location>
            <begin position="222"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="395" mass="43580" checksum="3FC1F478A99FA275" modified="2013-07-24" version="1">MVKERIGILGGTFDPIHEGHIHMALSAMQGAHLDRVLVLPTGNPPHKIGITPAEDRWRMVCCACALHDGLTPCRAEIDREGVIYTVDTLSILHQDYPKAELFYLIGTDTLMELHTWRNFEQVLSLCTFVICPRPTSISPKVLADEQRRLIALGGRFVALDADVVDVSSTELRQALRDGQATPHCSVPVREYCKVRGLYGLSPRVPQGDKWLDRLFADLNQHRFMHSLAVAHTARQLAIAHHLDPVKAEAAGLLHDCAKCLPLSAMQQLCRDHQLTVDPDILQSGALLHSVAGACQAQDVYGITDPELLSAITNHTSGRPGMSKLDMVIWLADKIEPTRASYPLLDKVRMLAGFSLEKALLTSLEGSANYLRSSGKTVHPLTLQTIAWLKTLPETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDE7</accession>
    <name>R7IDE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48602">
        <property type="protein sequence ID" value="CDE48602"/>
        <property type="gene ID" value="BN770_01744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="459" mass="50027" checksum="1EB5C2308CC2B3F9" modified="2013-07-24" version="1">MRFFRTSPEKLPAAESEMIFSKQDLKQLLLPLLAEQFLVVLIGMMDTIMVSYCGESAMSGVSLVDSINVLLIGVFSALATGGAVLVSQYLGQKRPDAAKTAAKMLFYVVLLVSLAIMAVCLIFRKPLLLAIFGTVEEDVMTASQIYFLMSALSYPVMAIYNAYCALLRCIGNPRATMFSSFIMNIVNLIGNSVTIFWLGWGVMGAGLATLISRSVGAYITQRALRDPHCRIPYPGMFPFEWHPSEVKKILSVGIPSGFENGLFQLGKLLLLSMIATFGTASTAANAVGNTLGSFQCPPGNAIGLAMIAVVGQCCGAHAYDQAKFYTKKLMQIVYLCMGTLNILMLLCNPIITLPFNLSPEATVLARQIVALHGAGCVIFWPMSFTMPNALRAAGDAKYTMTVAVFSMAVFRIGFGVFLATTMSMGVIGVWIAMQIDWVFRIICFLIRWHSGKWQTKTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDK5</accession>
    <name>R7IDK5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnhA</name>
        <name evidence="7" type="ORF">BN770_02041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="CBJB010000145">
        <property type="protein sequence ID" value="CDE49526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49526">
        <property type="protein sequence ID" value="CDE49526"/>
        <property type="gene ID" value="BN770_02041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="162" mass="18175" checksum="0D595E78510ED8D3" modified="2013-07-24" version="1">MTEARPRKQVNIYTDGACSGNPGPGGWGCILEFGPHRKEMSGYMAGTTNNRMELFAAISALGALKEPCDVKLYSDSAYLVNAFNEHWIDGWKKRGWKNAAGQAVENQDLWFILLAQTKKHHVTFYKVKGHADHPENIRCDELATGAIKEYRRINAMDEESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDU5</accession>
    <name>R7IDU5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48727">
        <property type="protein sequence ID" value="CDE48727"/>
        <property type="gene ID" value="BN770_01792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="154" mass="17317" checksum="8D3198979A571A5B" modified="2013-07-24" version="1">MPELCDLLNIQLSELFRGERMTMEAHQKAFDALLLEMKQREEAANRRILQLEKVLVCMTIAVSLTMILVGCYLAKDHLALGIALLTFGAAVVFAICFVGVKIEHDTGYYECPECGKRYVPTMKAVVMALHRGTARKMMCPFCGKCAYHQKVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEF1</accession>
    <name>R7IEF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49786">
        <property type="protein sequence ID" value="CDE49786"/>
        <property type="gene ID" value="BN770_02136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006901">
        <property type="entry name" value="TrmK"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018637">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="231" mass="25764" checksum="A747023726A66966" modified="2013-07-24" version="1">MLDERLSLAAQLYEPCALGADIGTDHALLPCYLLTHNICQEMVLADVSPKALLHAEESVRRHHLEKRAHVRLADGLDALTEPCGCVSMMGMGGETIRTVLLSGAEKLCGAVLVLSSHTEQPLVRRTLPEIGYHIVQEKLCQAAGRFYIFWRAEPGQADDWTAEEVHYGRLLWVQNSPKMLLDYCRYRIKVMDDRLTGLASAVGDVSQIRGEISAEIDFYQRKITELEGALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEL4</accession>
    <name>R7IEL4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49753">
        <property type="protein sequence ID" value="CDE49753"/>
        <property type="gene ID" value="BN770_02119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="289" mass="32292" checksum="4EC017EB8143BDDE" modified="2013-07-24" version="1">MQSMTGYGKETSRQGDWEMTVELRAVNHRFLDLSMRLGRGLTFLEETIRKTLAPLCRGHVDVQLTLRRISGSDSDVTVDETLAAAYMQAANTLQAATGAANDLTVSRLMQLDGVTTVTERALDEEALTAQCREVTALAMQHLTDMRIREGTHLRDDLQVHLDAAAALREQIASRAPQVVEEYRLRLTERLARLPIEPVDPARLAQEVALMADKCAIDEELSRLESHIAQMHVYLDVSGETGKKMDFLIQEMNREANTIGSKCSDAQMAQNVVNLKSEIEKMREQIQNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IET7</accession>
    <name>R7IET7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nodulation efficiency protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50135">
        <property type="protein sequence ID" value="CDE50135"/>
        <property type="gene ID" value="BN770_02295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="165" mass="17599" checksum="BDE71A051F3938FC" modified="2013-07-24" version="1">MIDFIMTNLPIIVCFVLGIGLLIMEALMPGFGIAGFSGIALEVVALVLTWQQHGTMATLGMLLIVLSVLAIAISTSLHSLTKGKLSKSSIVNSHTESTYAGYRSAEDMQVFLGREGTATTALRPTGLGEFDGVRLNVVSEGDFIENGTKIRVTQIEGSRIVVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEU0</accession>
    <name>R7IEU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50309">
        <property type="protein sequence ID" value="CDE50309"/>
        <property type="gene ID" value="BN770_02358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="74" mass="7315" checksum="93BE8F9E0FA9A989" modified="2013-07-24" version="1">MTALEGGNDAICAYTVTDAGSTVAIISNVSQKDTLTVSLDVLRGAELLGGIGGAAFADGTANLPPLSGIIVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEV8</accession>
    <name>R7IEV8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50329">
        <property type="protein sequence ID" value="CDE50329"/>
        <property type="gene ID" value="BN770_00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="119" mass="13346" checksum="B533BCC80BFCDCFC" modified="2013-07-24" version="1">MTVNYQDLGLRVRDARKAKHLTQEQLAEKVGISSSFMGHIERGTRIASIDTLVSVCNVLSVSPCLLLGASLSENAVDFPYTNDNRERSFMLDFVSLAQRTVRRWDETESAPEEAPKTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF11</accession>
    <name>R7IF11_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferases involved in cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000138">
        <property type="protein sequence ID" value="CDE49162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49162">
        <property type="protein sequence ID" value="CDE49162"/>
        <property type="gene ID" value="BN770_01924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="273" mass="32486" checksum="BC690558C3E775AB" modified="2013-07-24" version="1">MEHRPFISVIIPVWNGARYLDACLNSILRQSWQHFEVIIVDDGSRDATWNMLMRWKKQDARIIPFHQENAGVSEARNTAMRHASGDYYRFVDVDDQLPPDSLEQLVRCAEKNQSDLVLAAYTEVLGTTRTVRDLGKCTDTVESAEFLRRLERLSNSFYYGVLWNKIFRGDIIRQHDLRFTSGLHWGEDFVFVMQYLEHAERMSYITTPVYDYFRNPNGAVVRQLVNCFRHPIVSIQARLTVYRSYEQLYRARGLYDQYKRILWRYLFRFTLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF48</accession>
    <name>R7IF48_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50429">
        <property type="protein sequence ID" value="CDE50429"/>
        <property type="gene ID" value="BN770_02384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="33"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="399" mass="43551" checksum="88FD8DE0D09103F3" modified="2013-07-24" version="1">MALTISHRCQNIAPSPTLAIDARAKEMKAAGVDVIGFGAGEPDFPTPAYICDAAKEALDKGMTRYTPAAGTVALRQAICDKLERDNHLHYTPSDIIVSSGAKHSLYTIFQCILDPGDEVLIPTPCWVSYPEMVRMAGGVPVFIPSDERNNFIPTSHDIAARVTRRTKAIILTSPSNPNGSVWSREQLQFVADLAVSHPFYVVSDEIYEKLIYDGQKHVSIAELGEAIKNQTFVVNGMSKAYAMTGWRIGYVAGPRVEICAMTSFQSHATSNANSIAQYAAMKALQGDPQCVTDMVAQFEARRNAMVEKINSIPGLSCMKPQGAFYIMLNITGVMGKTYNGRVIDSSQTFAELLLADKHVAVVPGNAFEAEGFCRLSYAVAMESCMEGLRRIEEFVSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF84</accession>
    <name>R7IF84_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">leuB</name>
        <name evidence="16" type="ORF">BN770_02409</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50474">
        <property type="protein sequence ID" value="CDE50474"/>
        <property type="gene ID" value="BN770_02409"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="15">
        <location>
            <begin position="4"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDE50474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="357" mass="38784" checksum="5DB08B0F4857A877" modified="2013-07-24" version="1">MEKHIALLRGDGIGPEIVDSAVKVLEAVAEKFGHTFTFTRYLIGGAAIDETGNPLPQETIDGCLSSDSVLLGAVGGPKWDSQPANLRPEKGLLGIRAAMGLYTNLRPAKLYPALKDECPLRSDIVAQGFDLMMVRELTGGIYFGERGRREGQYGAEAYDTERYSVMEIERIARAAFDAARKRRKNVISIDKANVLETSRLWRETVHRIAQEYPDVTVSDMLVDNAAMQLVRRPSQFDVVVTSNMFGDILSDEASQITGSIGMLPSASLGATKRGLYEPIHGSAPDIAGQNKANPIATILSAAMMLRYAFDMADEADCIDRAVDAALNDGLRTADIVGQSDIQPLTCTEMTDAILARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFM9</accession>
    <name>R7IFM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50614">
        <property type="protein sequence ID" value="CDE50614"/>
        <property type="gene ID" value="BN770_02461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_C" evidence="5">
        <location>
            <begin position="349"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="530" mass="57577" checksum="80C4753493E5E0B4" modified="2013-07-24" version="1">MEVATGNVRKFSSMKELPLPLKDEVTIGIGLNNSSSYSNGSIIGGNSTDRALMSFLVDAGVDANVAREDVRNFNAFDSAKKYSTVTINHNGKVVTYIKGAPERIIARCQTYLDENGAVKPLTERNFLMTYMDEQAGRSMRLLGVAKCDGDTADGDSLTLVCVLAIRDNVRKEAVDAIREVQEAGIQVVMVTGDRKETAVAIAKEAGLLKHNTDVALTSAELAELSDDELKKVLPNLRVVSRALPTDKSRLVRCAQELNLVVGMTGDGVNDSPALKKADVGFAMGSGTEVAKEAGDITILDDNFLSIEKAILYGRTMFKSIRKFLIFQLTVNVAAVLTCFLAPLFGENEILTVIQLLVVNLAMDTLAAIAFGSEPALMEYMKEKPIARDASIVTGKMMSQVVVSGLYITAMCLCIRFVPALQHLLGAWSTGVLDTTLLNSAVFATFMMAISFNGFNARTEHTNPFEHLERNKNFLLVIGALLVLQFLFVTFGGAVLSVEPLSWTAWLVCLLIAFLIIPIDIIRKAITSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFS1</accession>
    <name>R7IFS1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50178">
        <property type="protein sequence ID" value="CDE50178"/>
        <property type="gene ID" value="BN770_02316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="930" mass="107744" checksum="81B48FB0D1214BD2" modified="2013-07-24" version="1">MIERRVVFHVQLVVQHAQRQTAVHRVFQEVVGNLAVNLDGHIRLAVENRFRTAGILIRLHGDVDCLLPVLAFTHRRQISLDGNALLAPLVADLIAIRNRTGIVQLLIDNGHLRAVRFAKNQPRAAVFDVLHHNVRRERFGQCDFVVRHAIIAQENRPVQLVLMDDLSVQITSIMVAKLLLHQVVRGGLVPRFSVFARVNSRVLEVNPARAGLFQIDGRLIRERNACRRVHIRIGVVQHNAFARRFKSETIVVAFRQRRFRRHHHRAFIFALTVAGQQRNGVRHILRIMLFHNIEVFDGVEQCLRLSRRHVVLHDFYSVFPFHLLVKRIAEVQLILNILRRREGVRRVPRYRIQTIGVFAVLRRIRRHTRVNRLHHIVTLVLPYIRGACLLFAVEFRRVCNLLILRGCFHRRFVLDYDLSVGVLEFQLRFAVHAGFHGEVIRVVFRGDRRVIRRDLRHIALAVRLRKQQTAVFVHKLVEHRVRQRLVLDVETVFVDGERPLNAALIGVVPAALLQLFNLNVSRVAVRGILGMIPLSATLRSESICQLIVFTGHSVLVERVFILNFVCFICRKRRQHIVRRHGIDLAAFVRRVRINVVNVRSRRTAGACTVRLDFCRSRVNSRHLTPVRVYFNLRDGHVCQGNLLIHRRHDVSSSRVLAVRALCGFDFDGILNRSFFPVDISPAFPSSQIAEDGVVAPVDVLPLHSGRCAAELDGQVVVAQILNIVLADFGAHLHGAGSVVMAGVFSDKVHILVGEPHFNLFRCGIILELKRRLFIAEFGVRARPDRSTVRFDMRILCRNNNLVAFAMAKNSFIRNLEVRREAIVVRIGIFRKYDVRYRNIGNLHAALADGRRFVRHHLEVRVKSKRRHHHVVRLRGISVHRRNHRKRRCRGRLVHRGNSFGGVFRRRGRHRRRKRRFFRRRRRCCGRFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG89</accession>
    <name>R7IG89_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-trcl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50328">
        <property type="protein sequence ID" value="CDE50328"/>
        <property type="gene ID" value="BN770_00157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026363">
        <property type="entry name" value="CxxC-x17-CxxC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04272">
        <property type="entry name" value="cxxc_cxxc_Mbark"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="97" mass="10943" checksum="6E172243BEA67823" modified="2013-07-24" version="1">MYEDETLVCRDCGQEFVFSASEQAFFAEKGFMNKPSRCPKCRAARRAQNGNGSSAPRQMYDVVCANCGKATQVPFQPRGDRPVLCRECFDAQRASRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGI7</accession>
    <name>R7IGI7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50438">
        <property type="protein sequence ID" value="CDE50438"/>
        <property type="gene ID" value="BN770_02393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="249"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="540" mass="59487" checksum="2C382AF40CDAFD27" modified="2013-07-24" version="1">MDPIYVCGHRNPDTDSVVSAMAFAALHNALGDNAYVAAMQGAPNDETQFLLDRFGFQAPTLLTNVRTQVRDIDYDRPPTLGTSVPISHAWAVLREDENLSAVPVTNEDGTLYGMLTAGGIAEKDMESITKPEVRDVPIFNLLSALEGHIINNEEDTFDTISGEVVIALPTPGECLKGVGSGSIVICGQQKDVVDKALEIGASCVIICQGSLSEKYLGLSSKTCIIATPCDAYRAARMIYQAIPVQRIAQHTGVVLFHLNDFIDDVRETVLQSRYRSYPVLDENEKVVGTLSRYHLLRPRRKRVVLVDHNEKSQSIPGLEQADIIAIIDHHRLADIQTGAPVFMRNEPVGSTTTIVATMFQERGLQPSEKMAGLMAAAILSDTVMFKSPTCTPRDRRMADRLARIAGIDLETLGREMFSAGSGADKPVEQLLNTDFKEFHIAGHNLGICQITCLDTDRMLERLPEILPEMQKIKDNKGYDMFLMMLTDVLRCGTELVFLGGDDAVRQAFNLNEDTSSHHVWLPKVVSRKKQIVPALALLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGL2</accession>
    <name>R7IGL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50939">
        <property type="protein sequence ID" value="CDE50939"/>
        <property type="gene ID" value="BN770_00248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="123" mass="14160" checksum="CFDA6FCC249DDA6A" modified="2013-07-24" version="1">MYNKPIIIITQKWWKSNTSDCLIETPVMLAAFYGLRRSEAVGLRWDAIDFQQNTITIQHTVIACRLNGKYEVIARDTTKTKSSRRTLPLAAPIRKYLLNTIFAFVCAICLCLFDFVVRSFHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGV3</accession>
    <name>R7IGV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar (Pentulose and hexulose) kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50825">
        <property type="protein sequence ID" value="CDE50825"/>
        <property type="gene ID" value="BN770_00221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="252"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="431" mass="47547" checksum="765D8892BAEAB340" modified="2013-07-24" version="1">MQRIFLAIDIGASSGRHIVGIEADGALQTDEVYRFPNGVQRENGHLIWDIEGIFQHVKAGIKAAFAKYPHIDSLSIDTWAVDYVLLKDGAALLPCHAYRDERTQAVIDEVHQHMPFAELYRRTGIQFQPFNSIYQLYEDAKTGRLQQADDFLMVPEYLLYRLCGVKAREYTNATSTGLVSAATKEYDPEILRALSLPARLFPRLTQPGTVLGQLTPDVAREVGGQTSVVLCATHDTASAVEGIPMAENAPFLSSGTWSLLGAKIPAPITTPESMACNFTNEGGVGYIRYLKNIMGLWIVQCIQKQLGISFAEMVNLARTSHYEQIFNVNDPRFSAPEDMAAEIRAALSPAPETDADLIRSVYVSLAHSYGEAIRELERLTGQTWEKLYIAGGGAKNALLNELTAQYTGKEVVALPIEATALGNLKIQREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH42</accession>
    <name>R7IH42_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ORF">BN770_02181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49902">
        <property type="protein sequence ID" value="CDE49902"/>
        <property type="gene ID" value="BN770_02181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="161" mass="16275" checksum="54EB008A6DA14436" modified="2013-07-24" version="1">MKKVAVIMGSDSDLPVLKGAFEQLKKLGIPFEAHVYSAHRTPAEAAAFAASARESGFGVLIAAAGKAAHLAGALAAQTTLPVIGIPVKSSTLDGLDALLSTVQMPSGMPVATVAIDGAANAALLAAQILAVEDEALAEKLLAMRKAQHDAVIAKDAALVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH99</accession>
    <name>R7IH99_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">secA</name>
        <name evidence="20" type="ORF">BN770_00312</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="CBJB010000199">
        <property type="protein sequence ID" value="CDE51174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51174">
        <property type="protein sequence ID" value="CDE51174"/>
        <property type="gene ID" value="BN770_00312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="2"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="855"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDE51174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="905" mass="102367" checksum="9E20D6FD202133B3" modified="2013-07-24" version="1">MFDWVKKLLGSSNDAEVKKLQKTVNAVEALEDEYKALTDEQLRAKTDEFRARLQNGETEDDILPEAFAAIREADARVLGMRPYRVQVMGGLVLHQGRIAEMKTGEGKTLVSTLPAYLNALSGKGVHVVTVNDYLARRDSEWMGKVHRFMGLSVGLIVHDLDSAERRAAYACDITYGTNNELGFDYLRDNMVIRQSELVQRGHNFAIVDEVDSILIDEARTPLIISGAGDKSTDLYAKVDAVVRTLKRDVHFEIEEKKKAISLTDEGAQRVEAAFGITNINDAENAELNHHVSCALRANFLMKRDVDYVVKDDQVIIVDEFTGRLMIGRRYSEGLHQAIEAKEHVTIERESRTLATITFQNYFRMYHKLSGMTGTAKTEEDEFQNIYSLDVVQIPTNKPNIRKDLDDMVYKTKKAKFNAVVDAIAQVHANGQPVLVGTVTVETSEMLSAMLQRRGIQHEVLNAKNHAKEAEIVAQAGHWGAVTIATNMAGRGTDILLGGNPEFLARRAMRQDGYDEEIIEAATGHAEDVSDEILAAREKYQSLYKDFKRTTDEAHDRVLQTGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSTQFFISLEDDLMRLFGGDRIMPMVERLGLKDDEPLQAGMLTKQIEAAQKRIEGRNFEIRKHVLEYDNVMNRQREIIYGQRRRVLMGENVRENIIGMAYKLIDAALSRHCASDDGTDWDIPQLTNYLENLCIHHGKIAELEDVIRSGDRDALAQALKDDAKAFYEERETALAEIGLDMREVERVVLLRAVDVRWMDHIDAMDRLRDGIGFRAYSGKNPVTEYQIEAGYMFDELNHLIREDTVRRMYQLRIERTPERVQAAVRPVEGKPIVPGNGQPRQPKRVKPSERVGRNDPCPCGSGLKYKNCCGKDKETRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHC9</accession>
    <name>R7IHC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized membrane protein (Homolog of Drosophila rhomboid)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49997">
        <property type="protein sequence ID" value="CDE49997"/>
        <property type="gene ID" value="BN770_02226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="201" mass="22225" checksum="2824E2ADA9FE6F62" modified="2013-07-24" version="1">MKNSKRLRISYNAPAILSFVLICFAVQLLNVLTKGASNRAVFSVYRSSFLDPLAYLRCVCHVFGHANWNHLMGNMMYILILGPMLEEKYGTSNMVFIMLVTALATGLANLIFFPNIRLLGASGIVFAMILLSSITITEEHTIPLSFILVAAIYIGQQAYQGLFTADNISQMAHIVGGMIGSVLGFVMNKYKMSRYERGSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHG3</accession>
    <name>R7IHG3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000183">
        <property type="protein sequence ID" value="CDE50896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50896">
        <property type="protein sequence ID" value="CDE50896"/>
        <property type="gene ID" value="BN770_00241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="45" mass="5308" checksum="FF7B9D030EC76837" modified="2013-07-24" version="1">MERIRKIPDDSDRVSPDEDDEDMSPYEPTYRDGSAKNECWRDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHI3</accession>
    <name>R7IHI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50062">
        <property type="protein sequence ID" value="CDE50062"/>
        <property type="gene ID" value="BN770_02263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="158" mass="17751" checksum="CA42BF522047C1C2" modified="2013-07-24" version="1">MLRTSLKDEIYRGNLLYVEGRFYLIADDVQEAPNCFMTHATPCLHFVKVSRKVNPQTDKFGFAVEDTGDRLHPLIDNFPAVLTFSGTMADAKNQAGAYFADMIEVKLQGNHWTDEIKTGDILTLEGNPGEYEVVSWIRDSLTAKQKGGVLTIQARRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHJ5</accession>
    <name>R7IHJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein AppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51105">
        <property type="protein sequence ID" value="CDE51105"/>
        <property type="gene ID" value="BN770_00031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="325" mass="36649" checksum="D26869B44344FDC8" modified="2013-07-24" version="1">MSEEKIILKAEDVRTYFPVKGALGQTVKEVKAVDGVSLALRQGETYGLVGESGCGKSTLGRTLIRLLEPTSGKITLFDQDITHLSKKEMLPFRRDVQIVFQDPYTSLNPRQRVGDMLMEVLAIHHIGDKNERMARALDIMAQVGLRPEHFYRYPHEFSGGQRQRIGLARALILDPRIVVCDEPVSALDVSIQSQIINLLKELQRKRGLTYLFVAHDMSVIRYISDRVGVMYLGHLVEEGDTDEVFDHPQHPYTRTLMSAVPSIDPRDNRQRILLEGDLPSPIDPPSGCVFHTRCPWATEACKTASCELREVRKGHYAACSRGEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHT9</accession>
    <name>R7IHT9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000213">
        <property type="protein sequence ID" value="CDE51339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51339">
        <property type="protein sequence ID" value="CDE51339"/>
        <property type="gene ID" value="BN770_00049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030947">
        <property type="entry name" value="EcfA_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04520">
        <property type="entry name" value="ECF_ATPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="280" mass="30706" checksum="C23EE9880B5A94BA" modified="2013-07-24" version="1">MNVCIDVQDVSFTYEDAPEPALHHVSLQVHEGEFLAVLGHNGSGKSTLAKLLNALYLPTEGHITVCGMDTQSDEELWEIRQKAGMIFQNPDNQLVATVVREDVAFGLENLGVPREEMIPRIDAALQAVGMSQFAEAAPHMLSGGQKQRIAIAGILAMQPSVIIADESTAMLDPSGRREVLSTIRRLNREKGITVVWITHFMEEAAQADRIIVMNQGEVALSGTPREVFPQVDALRELHLDVPHMTALADSLRRDGMPLLGNILTVDEMTKEVLTLLCPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7II01</accession>
    <name>R7II01_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HPr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50948">
        <property type="protein sequence ID" value="CDE50948"/>
        <property type="gene ID" value="BN770_00254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="75" mass="8411" checksum="CBC8A692D3091E65" modified="2013-07-24" version="1">MKSVNIKLNLMTDGAKFVQIVGAYPYDMDLRSGRHVVDAKSILGIFSLDWSKPVTMEIYSDDCDDLLAEIKPFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7II02</accession>
    <name>R7II02_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroK</name>
        <name evidence="3" type="ORF">BN770_00028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51101">
        <property type="protein sequence ID" value="CDE51101"/>
        <property type="gene ID" value="BN770_00028"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="165" mass="18059" checksum="714A09B9393F9269" modified="2013-07-24" version="1">MRNIVLIGMPGCGKSTVGVVLAKALGMDFVDSDLVIQSTMHATLAQLIEQHGDDGFRDIENRVNASIDVQNSIIATGGSVVYGAEAMAHLKSIGTVVYLRLTCENITERLGDLHARGVTIKPGWTLRDLYNERCPLYEQYADIVQDCDGLRLRDVVAELQKKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7II32</accession>
    <name>R7II32_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000222">
        <property type="protein sequence ID" value="CDE51454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51454">
        <property type="protein sequence ID" value="CDE51454"/>
        <property type="gene ID" value="BN770_00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007212">
        <property type="entry name" value="Zf-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04071">
        <property type="entry name" value="zf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="94" mass="11020" checksum="B7856C9E863BAD95" modified="2013-07-24" version="1">MPEQNKHYNFFQNKECEYFPCHKGVKEEDFNCLFCYCPLYTLGKHCGGHCTYTESGIKSCQHCTFPHQKKNYDAIIARFREIAAVAARSDREDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7II63</accession>
    <name>R7II63_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50252">
        <property type="protein sequence ID" value="CDE50252"/>
        <property type="gene ID" value="BN770_02335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="112"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="228"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="460" mass="48866" checksum="B0A9E05C585732F6" modified="2013-07-24" version="1">MLDQNVAREVLQEAVRTGGDFAEIFMEDRIDHAMGMRSHKLESATTSRTHGAGVRVFSGTNAIYAYTNDTSREGLMNCARQAAAAVRGGKGCVVAPFKPWDASRPEEILLLPTDVKAALKAEKLRAAEAAARSISPEIVQVMANYGDHVQDVCICNTEGVFVTDRRVQTRLRVSAIASNGTENQSGSDAPGASMGFELFDTRVNAEESGKIAAQQAVTMLHAPVCPAGVMPVAIDNGFGGVIFHEACGHSLEATSVGIGVSEFCGKLGQQIASPIVTAIDDGTLVNNWGQIHVDDEGTPSQRTVLIENGILKSYMVDRLGSRRMNHPITGSSRRESYAYAPTSRMRSTFIAPGNDSNEEIIASMGDGLYARKMGGGSVNPATGEFNFSVAEAYLVRDGKIAHPVRGASLIGRGSEILMKIDRVGKELELSQGMCGSKSGSVPTDVGQPMIRVSSITVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7II67</accession>
    <name>R7II67_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ORF">BN770_00309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000198">
        <property type="protein sequence ID" value="CDE51166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51166">
        <property type="protein sequence ID" value="CDE51166"/>
        <property type="gene ID" value="BN770_00309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="42"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="153"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="352" mass="37735" checksum="A72379D97B3D3AC0" modified="2013-07-24" version="1">MTYTESARAQLNALQTKDHVRILALETSCDETAAAIIEDGRTIVSNIVFSQIDLHALYGGVVPEIASRAHVETCDRVIDEALRAANMCLQDVDALAVTYGPGLVGALLTGVSCMKGLSYAANKPLIPVNHIEGHVSANYISNPDLKPPFLCLVVSGGHSHIVRVNDYGDYTLLGQTMDDAAGEAFDKAARVLTLPYPGGPRIDALAEEGDPHFLSLPHPHTPGKYDYSFSGMKTAFLNAANKMEMKGEPLPKADMAASFRYAVVSALVEKAMLAAKDTHAPALAMAGGVSANRLLRRMMQEAADKAHLPLYMPRLDLCTDNAAMIGSAAYYRMKKGELAPLTLNATPSLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIN1</accession>
    <name>R7IIN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Copper-exporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50452">
        <property type="protein sequence ID" value="CDE50452"/>
        <property type="gene ID" value="BN770_02399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="49" mass="5279" checksum="E177B07ACCFECEB2" modified="2013-07-24" version="1">MYGVQSPAESHEAGTAVVTLKADADENALKPLLKAVVEENDYEVKGFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ18</accession>
    <name>R7IJ18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplD</name>
        <name evidence="8" type="ORF">BN770_02453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50602">
        <property type="protein sequence ID" value="CDE50602"/>
        <property type="gene ID" value="BN770_02453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="207" mass="22417" checksum="A1345D5298560567" modified="2013-07-24" version="1">MAKTALYNMEGAAIGEIELSDAIFASDVNVAAMHLVVRSYLAAQRQGTQSAKTRTEVRGGGRKIYRQKGTGNARHHGNRAPQFRHGGVVFAPKPRDYVIAVPKKVRRLAFKSALTSKLNDGDIIVVDELTLSEGKTKLMANVLKKLGAEKKALVVLPEKDENVVRATANLPQAMTTYVNTLNVYDILNAGKVVLTKAAVASVEEVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJH4</accession>
    <name>R7IJH4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51636">
        <property type="protein sequence ID" value="CDE51636"/>
        <property type="gene ID" value="BN770_00538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="225" mass="23746" checksum="EEEC512CE6EFAF2A" modified="2013-07-24" version="1">MRLDSLLTSILPTPLTVSALLLCLASALVLGILTALVFTRGCRHTASFALTLALLPMSVALVIMMVNGSIGTGLAVAGTFALVRFRSVPGTAREIAAIFTAVAIGLAMGMGMLGVAVVFFLLAAAAVLVLTKLHFGAMPENAKALRITVPEDVDYESALPDVFRAHHVTATLEKVRTESMGTLFELTYQVNLPSAVPSKALLDDLRERNGNLPILFTNPGDKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJH7</accession>
    <name>R7IJH7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000223">
        <property type="protein sequence ID" value="CDE51473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51473">
        <property type="protein sequence ID" value="CDE51473"/>
        <property type="gene ID" value="BN770_00460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8614" checksum="779ECEBEF3295796" modified="2013-07-24" version="1">MFNRVPADENQAEFAHKVPKMTLTMAELADELHISLPTARKLVRKSGFPAFSVGSRILINREGLQRWLDGQPPIAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJN2</accession>
    <name>R7IJN2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">greA</name>
        <name evidence="12" type="ORF">BN770_00630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51820">
        <property type="protein sequence ID" value="CDE51820"/>
        <property type="gene ID" value="BN770_00630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="11">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="10">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="162" mass="17869" checksum="49F992CD800DD712" modified="2013-07-24" version="1">MAEEQKHNIMTAESLKKLQERYDYLLNVKRKEIINAIEIARGFGDLSENAEYTEARNDQAKNEAEITRLKALIENAEVVDESELSTDRVSVGITVRYENTDTGAQSEYGIVGAGADEADPDEGRISSESPIGAALLGKTVGDIVDVEIPRGTLHLRIVDIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK27</accession>
    <name>R7IK27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate synthase (NADPH) homotetrameric</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51980">
        <property type="protein sequence ID" value="CDE51980"/>
        <property type="gene ID" value="BN770_00732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="462" mass="49661" checksum="6C9EABFDBF842A69" modified="2013-07-24" version="1">MPNMSLQKHPMPEQQPDIRATNFKEVALGYTREIAMEEADRCLHCKNAPCVKGCPVNVPIPDFIAHIKKGEFQEAYETIRLQNGLPAICGRVCPQETQCESKCVRGIKGEPVGIGRLERFAADYAMTEGTVSAETAAPTGKKAAVVGSGPAGLTCAADLARAGWDVTVYEALHTPGGVLMYGIPEFRLPKALVQKEIDNIRKLGVKIVTNAVVGRAMTVEELLEEGNDAVFVGSGAGLPNFQKIPGESLCGVYSANEFLTRINLMRAYTFPEHDTPVKVGQRVAVIGGGNVAMDAARCARRLGADVSIVYRRSEAEMPARKEEVHHAKEEGIHFRMLTNPKAILGDENGFVRAMTCVEMELGEPDERGRRRPVPKPGSEFDLPVETVVVAIGNSPNPLIKKTTPDLPTETWGGITTDEHGRTGKKHVYAGGDAVTGAATVILAMGAGKKAAQAILEDAAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK52</accession>
    <name>R7IK52_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proton_antipo_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000254">
        <property type="protein sequence ID" value="CDE52005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52005">
        <property type="protein sequence ID" value="CDE52005"/>
        <property type="gene ID" value="BN770_00743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="123"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE52005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="682" mass="74079" checksum="550C450F326E873E" modified="2013-07-24" version="1">MTSWILILLTFLPFLAAIIAYMLGRRDERAMNGFVSITGIVIFALSVVLLFLPEGEVALPGFCGLGLYLRADGFRGLYSCVAAFMWMMTGLFAPEYFQHHGNKARYSFFTLMTLGATLGVFLSDNLGTTFLFFEIMSFASYAWVAQEETPGALRAAATYLAVAVIGGLTTLMGLFLLQHQLGTLDFASLRAAMGQQDVTVAVWLTLVGFGAKAGLFPLHIWLPKAHPVAPAPASALLSGILTKSGVFGLIVLCANLMQGNAAFGNALMIFAAITMFLGALLALFSTDLKRTLACSSMSQIGFITLGLSVMVLLGDEGTLAAYGSVMHMLNHSLIKLTLFIAAGVVYMNLHALNLDDIRGFGRKKPLLHIAFLLGALSIACIPPLGSGYNSKSLLHEGLLELIGEMQAAGSAWMGYKAIEVLFLISGGLTVAYMAKLYICIFWQKHPTHQAEFDGMTHYMNGTTAFALLGSAAALPFLGALPGLLLTPFGAKSASFFGVPALKEAIAYFSAENLQGAAISIIIGAAVYLLIVLPLLTRKDESGVRLYVNRWNEKLDLENAIYRPLLLTLLPQVLTLVFRFIAELPENIVMASRATIFRMRKTRKPVPVGNRFTYTLGRALNALARLLNRTILHRHPMRTDFEYVLDASFREVSSGIRSMSVSISFGLLLLCIGLYVTCLYLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK78</accession>
    <name>R7IK78_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe-ADH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000237">
        <property type="protein sequence ID" value="CDE51708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51708">
        <property type="protein sequence ID" value="CDE51708"/>
        <property type="gene ID" value="BN770_00578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="186" mass="19945" checksum="F407AB3FA98A2BF9" modified="2013-07-24" version="1">MKQLPLPAHPVFPSRLDSIAALPELLRSRQIGCVLVIGDAHAVDCESLLLPVLEDSQIMYAVHAAVSLSDSKDGALTRTDVDTALQAFTDKQAQAILAVGGNDAMALGQALLARLHTKGHAETFEQWRAIPLILLPAAADASAVFAPPSPRRRMLPPYSQKQVTCSTRCAENHAAFRFGRIPAAMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK94</accession>
    <name>R7IK94_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.399</ecNumber>
            <ecNumber evidence="7">1.1.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_00585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="6"/>
    <dbReference type="EC" id="1.1.1.95" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000239">
        <property type="protein sequence ID" value="CDE51723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51723">
        <property type="protein sequence ID" value="CDE51723"/>
        <property type="gene ID" value="BN770_00585"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="319"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE51723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="388" mass="40835" checksum="70C49AD6E95D3354" modified="2013-07-24" version="1">MFKIKTLNAISDVIHEELSAEQYVISPEEPVPEGILVRSAVMHDAPLNPELLGIARAGAGVNNIPLDKCTKQGIAVFNTPGANANAVAELVLGALVLGSRNVAAGIRWADTLKGQENVPKLVEKGKGQFVGPELRGKTLGVIGLGAIGRLVANAASAGFGMKVVGCDPFISVESAWALSSSVRRAATNEDVFAQVDYITFHVPLNDKTRGSINAATIAKMKKGAILLNFSRGELANTADVKAALASGQLGGYVTDFPCEELLGVEKVTCIPHLGASTPESEDNCARMAAAELRDYLEVGSIRNSVNLPDVPLGAPEGVRVLVIHENVPNMVATITTCVSAEQINIDNLVNKSRKDVAVTVMELSDRPSKMALNVISSIAGVIRVRVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKQ9</accession>
    <name>R7IKQ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51893">
        <property type="protein sequence ID" value="CDE51893"/>
        <property type="gene ID" value="BN770_00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="126" mass="13452" checksum="418AE0DBC01FE9D2" modified="2013-07-24" version="1">MNKILSTKNAPAAIGPYSQGVQAGNTVYVSGQLYFVPETGELLEGTIGEMTEQCMKNIAAILAEADCTLADIVKTTIFLKDLNDFAAVNEAYGKFFPQNPPARACVQVAKLPRDAKVEIEAIAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILW5</accession>
    <name>R7ILW5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Beta-galactosidase</fullName>
            <ecNumber evidence="3 9">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 9"/>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51627">
        <property type="protein sequence ID" value="CDE51627"/>
        <property type="gene ID" value="BN770_00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="10">
        <location>
            <begin position="733"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113462" checksum="0AD6093E9F20B26E" modified="2013-07-24" version="1">MKQIARERFETAWLSNPEIFSVHELPDCSDHAFYATMAEADTDTSSLVKSLDGAWKAHFAMKPSEAPDTLLTSAALDETLREIQVPCEFQMEAPEWDPPHYVNTQYPWDGHEALQAPQVSEVYNPTVTCIRHFALSLPQVQQRTVLHLAGVEAAVLVYVNGHEVGYAEDSFTPHRFDLTPYVHVGENRLALRVFKRCTGSWMEDQDFWRFSGIHRSVSLHFYPETHLYDLRVRTPLTDNYTRATLETRLRVMGASLGKAKLTLTDKAGKTLWTAEKPLTALESYVSAEIPGVKLWSAEEPNLYTLTVVLTNAQGQVTEVCRTKVGFRQFEMKDKIMCLNGKRIVFHGVNRHEFDCDRGRVMTHDLLMRDIRDMKAMNINAVRTCHYPNTSEFYRLCDEYGLYVIDEANIETHGSWQPMHDWVVPDNRPEWQEAVLARGRAMLERDKNHPCILLWSCGNESWGGKDLYELSQYYRREDPTRLVHYEGVANDPRYPDTTDVHSNMYRRVASIEEYLQSNPDKPFINCEYTHAMGNSCGGMSLYTALEDKYPMYQGGFIWDYVDQALRVKAPNGQERLAYGGDFGDKPTDWQFNTNGIILGDRTQTGKCQEVRYLFRDVFLTPDETGVTVKNRRLFQTLTGYDVRWTLECDRKPISAGETLLPDIAPGESVHIDLPFGTLPEGQTVVTCFLVLREKTGILEAGTVLSHGQTVLGAMKKAETPDNAPAPVIGDCNVGFRGEGLGVLLARRGGIISFRDRLGRETLLRAPQLSLFRASTDNDRGNGNNIQQGVYHLISRHSACSDADIQQEAGRTTLVYRYTTPMLPDFAVTVRYTVHSQDALDVTVDWPGLPNQPDMPALGLSFQLDPRLTRVRCYGYGPDENYIDRREGAYLGWHSWNAADGMTRYCKPQESGNRMGVQVVSVTDADGHGVEISGDNLEVSVQPWLPEELEAAYHPSDLMGSVRTVLDVAMFRKGIGGDDSWGAPVLPQFCYPADKPYTFTFTMKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IM15</accession>
    <name>R7IM15_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51667">
        <property type="protein sequence ID" value="CDE51667"/>
        <property type="gene ID" value="BN770_00564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="164" mass="19429" checksum="F2F8D088A05D944E" modified="2013-07-24" version="1">MIWGIVTAGAALLLILVALLHAQRRRNRLEKEMVERARTTDLYRALYPVLRTANRCCVDRVLIRRDEVRIVLFKPMNSVYRFVFEERGFDRVNDPKVLKALALAISADMDHLRDNRCYSFSVRQDITAQGDKVYWYEYNILPYYKDTLTKAWYHQPEVEDGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IM43</accession>
    <name>R7IM43_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51692">
        <property type="protein sequence ID" value="CDE51692"/>
        <property type="gene ID" value="BN770_00570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="210" mass="23273" checksum="F622B81605D3CA96" modified="2013-07-24" version="1">MFWDNVAWVYDIFADGINRKANRKLCKVVAGLISPTDDVLECACGTGLLSGVIAKRCKSLTATDFSAKMLARARKKYGQYPHVRFEQADILHLPYSDARFDAVVAANVIHLLDNPHQALRELDRVCKPGGKLIIPTYMNRTGKGKTNRVSGVIGKAGADFKREFTLETYRQFFADAGYTDVQYTMCEGRIPCAVALIRMGASADARRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMX3</accession>
    <name>R7IMX3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51982">
        <property type="protein sequence ID" value="CDE51982"/>
        <property type="gene ID" value="BN770_00734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436073" description="NlpC/P60 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="104"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="297" mass="33740" checksum="3BBC4C3C68249180" modified="2013-07-24" version="1">MKKLTALLVLMLTMVLSILPAQAEVERSKLLDAAFSMLEEGNDFVRRYNEMTGAEVTATFVDGCPYFFGGKADDETTLTRLFSRAPLYSKREIWEQTRFYDKGSYYLYGLDCSGFTQWVYAEAGLPKHDSLSNMILQYGKYGKNHVYSHRKGKGMPSYDKLAENLQVGDLLVAKKRARHIMMFIGTLRDFGYTEEELPELAPYLDYALVIHCGPNFAYTDRIQAFLDAHQDDSYYKGVKTTDGGVAISIIGVPFGDAPNRGSYGVNDFAWFDMPDGYKLTIWDLPNATSFCWFRMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3L1</accession>
    <name>R7I3L1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46215">
        <property type="protein sequence ID" value="CDE46215"/>
        <property type="gene ID" value="BN770_00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="2">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="3">
        <location>
            <begin position="206"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="490" mass="54734" checksum="F19C4431DBAA1C82" modified="2013-07-24" version="1">MERLNAAMAPAPVRPVKVLQFGEGNFLRAFVDYMIDIANEKSDFNGSVALVKPIQMGTLFPAFKEQDYRYTVMLRGLVDGQAVEQTRVVTSVADAVDAYADYAHYADYAKLPSLRFIVSNTTEAGIVLDETDEFSLCPPKSYPGKLTKFLFERAEAFDYAQDKGLIILPVELIDDNGIMLKKCVKALAKQWALGEKFEQWLETACVFTSTLVDRIVTGYPRGEDQAIWEKLGYQDNLLDTAEPFGLWVIESPRDLSDELPLPQCGLPVIYTDNQKPYKQRKVRILNGAHTSFVPAAFQCGYDIVLDAMNDPMISTFMQKTLYDEVIPTLSLPKADLMAFAEAVTGRFRNPFIKHALLSICLNSVSKWRARCMPSLLGYVEKTGELPAHLTFSLASLMSLYRGGKLTGDGRLECQRDGQPYYLQDDAAVLNFFAETSSESPEEQTKEFLSNEAFFGAELCKVPGLVESVGASLREILDKGMRTVMNEKFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3M4</accession>
    <name>R7I3M4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein BN770_00913</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46504">
        <property type="protein sequence ID" value="CDE46504"/>
        <property type="gene ID" value="BN770_00913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="299" mass="33798" checksum="F66B1993D7EDCD5D" modified="2013-07-24" version="1">MRFLVVTGLSGAGKTSVNRYLEDMGAFCVDNLPPNMMFRMMEAIEKSALHRPLVAMAVDVRSGEFFDAKSVSDLIAESRQLGYQIETLYLEASDDVLVSRYKETRRDHPLAGENVSLIQAIGKERAIMQPLRETANYIIDTSVLKPRQLRQKLEMILSGDSQPDAMHIEMNSFGYKRGLPMQADLVFDVRFLPNPFYIPGLGRHTGLDADVRDFVLNHPVTQEFMTKMQSLLTFLIPHYQEEGKHRLSIAIGCTGGAHRSVAICEALAAFLREQGYAISVTHRDLELEQAHWKERPEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3R9</accession>
    <name>R7I3R9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ORF">BN770_00002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000001">
        <property type="protein sequence ID" value="CDE46131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46131">
        <property type="protein sequence ID" value="CDE46131"/>
        <property type="gene ID" value="BN770_00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9425" checksum="4BC0D69C648DAC5B" modified="2013-07-24" version="1">MAEEKKVSDQKPNVFVRIGRWFKNLPGRIAKSFKNMAAELRLVSWPSKKKWIACSVTVLVFVLVMSIVIGALDMGATALVKLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I469</accession>
    <name>R7I469_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46445">
        <property type="protein sequence ID" value="CDE46445"/>
        <property type="gene ID" value="BN770_00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="412"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="453" mass="51616" checksum="208A608F68A07B4C" modified="2013-07-24" version="1">MQFPKDFLWGTATSSYQIEGAANEDGKGKSIWDVFTHVPGTVKDRSNGDVAIDHYHRFREDIRLMAKMGIRNYRFSISWGRILPDGTGAVNEKGLAFYSELVDCLLENGIRPFCTLYHWDLPYALHLRGGWLSPDMPEWFANYTTIVADALGDRVKAFITINEPQCIIGSGYALGVHAPGLKCCAADIVRAAHHLMLAHGRAVQVLRAHVPGVRVGYAPCGDPCVPYTNSPEDIAAARKEYFTVHIDEKVGPAWNIAWFSDPVMLGQYPADGLVGYEQYLPDGWQEDLKTIHQPLDFYGQNIYQGQWWRRGADGKPEHVRYPAGHPHNALEWPINEDGLYWGPRFLYERYHTPILITENGMDAHDAVSLDGKVHDPNRQDYMHRYLRALGQAVADGVPVLGYFYWSFFDNFEWAHGYQERFGLVYVNYQTQERILKDSAYWYQQVMATNGENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4C3</accession>
    <name>R7I4C3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_00904</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46495">
        <property type="protein sequence ID" value="CDE46495"/>
        <property type="gene ID" value="BN770_00904"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="157"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="11">
        <location>
            <begin position="365"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE46495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="483" mass="54320" checksum="05CE969596867375" modified="2013-07-24" version="1">MANRPQENPTMLCDFYELTMGNGYYRNGFYKRNVYFDVFFRNVPDGGGFAIAAGLEQIVEYIQQLHFSDDDIAYLRSKGIFDEGFLNYLKNFKFHGDIYAVPEGTPVFPGEPLLTVRAPAIEAQLIETYLLLEINHQSLIATKANRIVRAAQGRAVLEFGSRRAQGADGAVIGARAAYIGGVAGTACTLTDVLYGVPAGGTMAHSWVQMFPTEYDAFKTYCELYPDNATLLVDTYNTLKSGVPNAIRAFKEILLPRGITNFAIRLDSGDISYLSKKARKMLDEAGLPNCKITASNSLDEYLIRDLMMQGAQVDTFGVGERLITSKSNPVFGGVYKLAAIEDDEGNIIPKIKVSENTAKITNPHFKRLYRLYDRESGKAIADELTLRDEVIDPTKPHVIFDPNATWKTKELTDFTVRELQVPIFQNGELVYELPELNDIKAYCRQQIHTLWDEVKRFENPHTYYVDLSQKLWDVKRGLLEAAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4E8</accession>
    <name>R7I4E8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46346">
        <property type="protein sequence ID" value="CDE46346"/>
        <property type="gene ID" value="BN770_00829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="197" mass="22340" checksum="FCCD312582CD414F" modified="2013-07-24" version="1">MPTIVSFYQRFPNEAPPLNLSAFDHTGYTYAENFRRNERCYEAEQCEVTSDDGSVVLSLDVRIRPRGGEIEALPRVMLSVYSEGMLFQVRRMELRTGDTTYAILPDNVQQYTMRGDTDGGFLETMAIPLGKVGMKMLLEASDAAEARWVIQGARTAQTLPLTAAQKKAIRRFCMDCEESAITYQPAFLWYKDYCTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Q1</accession>
    <name>R7I4Q1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46839">
        <property type="protein sequence ID" value="CDE46839"/>
        <property type="gene ID" value="BN770_01047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436159" evidence="1">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="204" mass="22347" checksum="7DC400030FAA55B2" modified="2013-07-24" version="1">MKKLLALAAAITLLCTAALAEFDFYALKDTPDAMTYTVPGTADTVVRPALAPYQGEFGEDELVAYLDYIILPDEEVATFRLCLSLSMFDSFQADEVRVTVDKKCYTFAVKPAITDYDGIFMEDYTLVLSSESFSIVTALSKAKNATTMQVVFVNTMDGAERAGSVEIPSADVQTLLTRYNDLGGSKQDLSVLMDKYPCTVEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4T6</accession>
    <name>R7I4T6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VTC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46506">
        <property type="protein sequence ID" value="CDE46506"/>
        <property type="gene ID" value="BN770_00915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="27773" checksum="86BA736EE6C63994" modified="2013-07-24" version="1">MARNIPLRHELKFFINEMQYQVLSRQLDRVLWRDPNGDVNNEYHIRSLYFDTIFNDAYFDKMDGDQNRDKYRIRIYNMRDTNIKLECKTKVGSLISKRSLGIPRDLAEQIIACDPTGLEQTRYGLLSDLYREMTCNLLRPVVIVDYVREAYLHPAEEVRITFDKQLRSGMNSIDLFNPAVATVPPFDNNDIILEVKYNQVMPPYIRDLLNYYCPNALSSAISKYTWCRRFEAMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4U5</accession>
    <name>R7I4U5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type polysaccharide transport system permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46243">
        <property type="protein sequence ID" value="CDE46243"/>
        <property type="gene ID" value="BN770_00799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="36041" checksum="9408B06878FC27A0" modified="2013-07-24" version="1">MQAPAQIKHRKAPLKTRLWNYKWFYVMFLPVFVALIVFHYLPMFGISLAFFRYQPSKIANPLEFTGLANFQKLFSRPQFWSSFTNTLEISIIKLLLNTFMAVIISLLLNEMVSTKMKKLSQTIIYLPHFMSWVVTAGVFGMLFAPTSAGLVNQVLIQMGLIDKEIYFLGDNDWWRFSYYIINIWHDTGWGTIIFMATLTGIDPGIYEAASIDGAGRWKKMRYITLPALANTIVTVLVLNLAKIMNLFESVFVLQNAAVYKTSQVLQTYVYYQTFNSGGNVNFGYTTAIGLFRSLVGMALVLICNQVSKKIRGRGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6A2</accession>
    <name>R7I6A2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemolysin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47021">
        <property type="protein sequence ID" value="CDE47021"/>
        <property type="gene ID" value="BN770_01115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="30450" checksum="740A6BB2B411B555" modified="2013-07-24" version="1">MSEKQRADVALVERGLCESRTKAQVSIMAGEVYVGTRRIDKASELIKPEDELEIRGKSNPYASRGGLKLEKAITSFQADLRGKVCMDIGAATGGFTDVCLQNGAAHVYAIDVGYGQFSWKLRNDPRVTLYERTNARLLTPDMLPLHPTVTVMDVSFISIRLILPVAAQLMGEEGVFYTLIKPQFEAGRDRIGKKGVIHDPKVHEDVLREIVEFAPSIGWQVQQLDYSPIKGPEGNIEFLGKITVRTQETEPVTPEIIHELVKKAHQELKGSSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6M7</accession>
    <name>R7I6M7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ORF">BN770_01193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47270">
        <property type="protein sequence ID" value="CDE47270"/>
        <property type="gene ID" value="BN770_01193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16635" checksum="8754B496E4466774" modified="2013-07-24" version="1">MARTTARAAVMQMIFEHMAGGEGGEETLQMVYEALRKEGLPGVDSISENEPSESDRAYITEVLDGVLAHLDELDEAIQAASPRWEISRMPHVDLTILRMAAWEILYEEGIPGPVAINEAVNLANRFSEPTSGRFVNGVLGTILRRKQAENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Q4</accession>
    <name>R7I6Q4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein ChrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000042">
        <property type="protein sequence ID" value="CDE47305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47305">
        <property type="protein sequence ID" value="CDE47305"/>
        <property type="gene ID" value="BN770_01206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="181" mass="18871" checksum="2F41CF9F95D0E8B8" modified="2013-07-24" version="1">MMVLFLVFFQIGLFSVGGGYAAMPLIQSLVVESHGWLTMAEFTNLMTIAEMTPGPIAVNSATFVGMRCAGLPGALVATFGCITPSLILVTLLSYLYGRFRSGQTMQNVLGALRPVVVALIASAALSIVQVAAVKSGGGVSIVGIVLMAAAFLVLRWKKWNPILVMLLCGIGGAAAHAVGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6W6</accession>
    <name>R7I6W6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="6">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="6">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="6">IPP transferase</shortName>
            <shortName evidence="6">IPPT</shortName>
            <shortName evidence="6">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">miaA</name>
        <name evidence="10" type="ORF">BN770_01230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6 8">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6 9">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47385">
        <property type="protein sequence ID" value="CDE47385"/>
        <property type="gene ID" value="BN770_01230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="308" mass="34688" checksum="8B6B22CD70E4D1FD" modified="2013-07-24" version="1">MKETCWVLTGPTASGKTALSLRLARTHDCEIVCMDSMQIYRGMDIGTAKPTADERAQAVHHMVDVADPTEDFSVARYQEMAESCIADIQARGHRALLVGGTGLYLRALRQPMAMGEAAADESIRQELQQIADAPGGKEQLHQQLAAVDPDTAQRLHLNDVRRVIRALEVYRLTGRPFSQQPQIKTDSRFSYRVASLTMPRDILYARIEQRIDQMLADGLAEEVSRLLKSGVPRDAKAMKAIGYKEMIPYALGETTLDEAVYALKLNTRHYAKRQLTWMRREEDVLWVDALEPDAYDKLEAYYTQGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7I734</accession>
    <name>R7I734_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 12">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">murC</name>
        <name evidence="16" type="ORF">BN770_01148</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 12"/>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47093">
        <property type="protein sequence ID" value="CDE47093"/>
        <property type="gene ID" value="BN770_01148"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="15">
        <location>
            <begin position="117"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="14">
        <location>
            <begin position="318"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="119"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDE47093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="467" mass="51031" checksum="EB48ACEC59F70FFB" modified="2013-07-24" version="1">MNTPQIQDFAGKRIHMIGIGGSSMSGLAQMLQHLGYQVTGSDQNDGYLMNDVRQAGAKVTIGHRAENVHGADLVVYTAAIPLTNPERAEAERLHIPSMERAELLGQLMRHYARAIGICGAHGKTTTTSMLSEILVECGLDPSVHIGGKLDAIGGSTRIGHSDIFAAEACEFNRSFLHMHPTMAVVLNIDADHLDCYKDIDEIEETFGQFLHLLPDNGVAIGKGTDERVVRQLSRLSCRTITFGLTADCDVHPAALTEDDNGYYTFDLCVQGNILAHVKMGVPGRFNVENGLAALTAAWVLGADMTKAAESLARFTGAHRRFELTGLLNGAEMFHDYGHNPAEMRNAVAIARKRCKGTLYAVMQPHTFDRVKHLFNDYLTCTEAADVTVVMDIFSAREKRENYPDLDSGKLVAGMQAHGLNAVWTPSFDDTEAYLRAHLKPGDLAITMGCGDVNLLNEQIEQHEKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I741</accession>
    <name>R7I741_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47465">
        <property type="protein sequence ID" value="CDE47465"/>
        <property type="gene ID" value="BN770_01266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="471" mass="50234" checksum="2B25A7102B506655" modified="2013-07-24" version="1">MFFDTIAAINKVVNDFVWGVPAMVCIIGVGLLLSVRTGFLQIRKFPFALKTTIGRMFHKKEAADGAMTPFQAVCTALAGTVGTGNIAGVAGAIAIGGPGAVFWMWCSALLGMCTKYAEVTLAVHYRERSATGEWIGGPMYYIKNGLGKRWQWLAILYALFGTLTVFGTGNATQVNTITTAINTAFMQFHLISESFLPTLNLIIGIFCAMLVAMVLLGGIKRIGSVSEKLVPFMALFYVVLGIGVVLLNLERLPGVLQSIFEGAFNPAAFTGGIIGSLFVSMQKGVSRGIFSNEAGLGTGSIAHACADTQKPVTQGMFGIFEVFADTIIICTLTALVILCSGTPVTYGVAAGAELTISGFMTTYGSWSSIFTAVALCCFAFSTIIGWGLYGSRFVQFLFRSNKVVRPFLVIYSFVSILGATLDLGLLWDIADTFNGLMSIPNLIALLLLSGMVVKLTKEHFPGKGAVRKTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I747</accession>
    <name>R7I747_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47286">
        <property type="protein sequence ID" value="CDE47286"/>
        <property type="gene ID" value="BN770_01199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="242" mass="26915" checksum="34C44975096ABDE9" modified="2013-07-24" version="1">MKQFGLIVSDPSQDSALRQSISSLLSVQEIPFSGFTDAPAPLFADCPDTRAAFLFRAAYALMQPGQPLPADLLLRHLSGDAQPGNVIRKYTRLQLSFLPYLRPGRAILPLDGGVRIGDNLLVLRLSDEGTIDASLPDGLWAELSGLCWTGRCRQIRGYNALPVLIRENALFPVGVNDRTTDADDADRVVLHWFQPDFTTECTLADGTFYRVTQIGAGFRWETNATKEWHLIIHRGSEEQFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7D9</accession>
    <name>R7I7D9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heparinase II/III-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47555">
        <property type="protein sequence ID" value="CDE47555"/>
        <property type="gene ID" value="BN770_01281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="340" mass="37118" checksum="CD3DFCAD5D689E56" modified="2013-07-24" version="1">MAAGSLLDCLELMAEAGLTCWDEPKLRNMLRFPLLMSLGNGYFANFADCDARPVMYGERLQRAGELLRDAPLTAMGQNLRGQPTDCIGDVPHFSRLLQRLFHPAGAGQSAGDTQDTLLPDLQVRIIRRSGWTLCIKGGHNGESHNHNDVGSLMVYVDGDPLLVDAGNMVYTAKTFSDARYTLWNCRSMYHNVPLIGGFEQCAGAEYTARNFRALPDGASLEIAGAYPAEAGVLSAIRGALVTTDGGQIADEITLQAPEAVAFTLIAREKPEIRPDGIEFAHARMEISPMLAAAVEEIPVTDARMAKNWHGSLWRIALTAEAGRHHRLSIKISRNNFANQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7F0</accession>
    <name>R7I7F0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47565">
        <property type="protein sequence ID" value="CDE47565"/>
        <property type="gene ID" value="BN770_01285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="724" mass="77420" checksum="1490BDC7ED64FF34" modified="2013-07-24" version="1">MFNRETQKNWMKSQVAHSLRGRLRLRVEGLNFLNDEKEEIAQMLANLPGVQCVQVTPITCGILLRFDPTATDTSILCEGVDVTMARYAMNAYRNRQAGSKPEEPEVSMTTKQLTKRLALNAGAVVLGHTILPGSLLGGAMASFTSLEALTSLGLTMPMARSAAAGLRRDMRPNADFLTVTSIVASLLLGTPHSALMILALSDLAELMTSYTIERTRSSIKQMLSVEDGEVWKVLSDGRLEKTPIGKLEAGDTIEVHTGEKIAVDGTVVSGSAVVDQSAITGEFVPAEKRKGAEVFAGTVVKNGNMQIQAQRVGDQTVVSRIVGMVEQSELKKAPIQRYADKFSNYLVPLNFLLCAAVWLVTRNPQKALKMLVIDYSCGIKLSTATAFSAAINTAVKRGVLIKGGAYIEQMSSANTVLLDKTGTITEGRPRVTGMTMLTDTMDEAEVLSLAMAAEETSTHPLASAILTYGRAHGAKIPPHGEIVTEVSRGSRTEVDGKCIRVGNLKYMKENGVRADVAIPDANGAIPNYVGVGDKIVAVLYAMDNPRANVRRAINALRYDGVGDIELLTGDMAAQAQAVAEMVGVDGYQAQLLPEQKAEAVLKLQTQGNGVVMVGDGINDAPALAYADVGISLGSKSTDIAMETSDVVINRDDPMMIPELRRLARATMRIVQQNFAMVIGINTVGLILGAASGISVLASALMHNMSTILVVANSLRLMVFPPMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I809</accession>
    <name>R7I809_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000046">
        <property type="protein sequence ID" value="CDE47418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47418">
        <property type="protein sequence ID" value="CDE47418"/>
        <property type="gene ID" value="BN770_00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436238" evidence="1">
        <location>
            <begin position="26"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="364" mass="41559" checksum="5DE94D07B7ACF44A" modified="2013-07-24" version="1">MKHNLRMAFLSLLLVLTLGVMPVFAESADHAMDWTHGIGSRYRTDVTSALPFEDELFFISGSQLLRVDDPEYEPEVVCNLEDIIWSEALKQSGYYGQVMLLNGGAELVLFSANEGRLYSFVPPTDDTMVRMQMVTELDYSTVPQMGWKKFPIAKDLYDVTVEQAVYDAQYGLYVIAKDKTDEYQIVRFDVDTGKGEMMEFALEDEEDSHLLTDMPGIFQWSGTSSKYERTLYDGKVLTTVDLSSGEATKAVHNWVNTLTLQPIPDYDVTLGDYVTHDAYYAYAPNKDNSAMYFVHDNTVWVMDYDEETSEFGEPHGIDKLPFFAEDTMCGFYWRGFYLIQTHDGLYLCHTGDETARAYLYGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I812</accession>
    <name>R7I812_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATP-binding protein PAAT family (TC 3.A.1.3.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48009">
        <property type="protein sequence ID" value="CDE48009"/>
        <property type="gene ID" value="BN770_01489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="247" mass="27760" checksum="4754A578640AB1D4" modified="2013-07-24" version="1">MAMLEINHLQKKFGTTEVLRDVSLSVSKGDVVAILGPSGSGKTTLLRCVNFLERADAGELLFDDEKFDLNRASHRDIARIRQKTAFVFQNYNLFRNKTALQNVTEGLIVARKMKKADAEAIGRKLLDKVGLSDRCDHYPAQLSGGQQQRVAIARALATNPEIIYFDEPTSALDPELIGEVLNVMRQLAEEGMTMLVVTHEMNFARHVSNRVVFMEGGRIIEQNSAQEFFAHPKEARTQEFLAKINQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I839</accession>
    <name>R7I839_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription regulator of sigma-E/sigma-K-dependent gene spoIIID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47453">
        <property type="protein sequence ID" value="CDE47453"/>
        <property type="gene ID" value="BN770_01255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014208">
        <property type="entry name" value="Spore_III_D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12116">
        <property type="entry name" value="SpoIIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="99" mass="11316" checksum="C7C587CFC03593E4" modified="2013-07-24" version="1">MDEAIAQRCIAEARYMLRHRTTIRQTAAAFQLSKSGIHKDMLQHLPQADAALAREVSALLAYNKSVRHLRGGEATRRRYAQEKSRKSAECLQFPENTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I883</accession>
    <name>R7I883_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46712">
        <property type="protein sequence ID" value="CDE46712"/>
        <property type="gene ID" value="BN770_01011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12554" checksum="9520A7B02C9053BE" modified="2013-07-24" version="1">MTLEVLFAQQGQAETFLRMVLLGAAFALALTLGGAWRHRHGLSDAADVLCALMLTLAALLVLIHSGEGLRLYALLGLLLGAVLWETGIRRIFRWIGKRLKKSFPSGRNMQNHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8C5</accession>
    <name>R7I8C5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48134">
        <property type="protein sequence ID" value="CDE48134"/>
        <property type="gene ID" value="BN770_01549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="230"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="405" mass="45910" checksum="FF6BA454D287B1F5" modified="2013-07-24" version="1">MKILMVNKFLYPRGGAETYMLRIGEELTRRGHQVEYFGMYDEKNTVGNAEGLTTVNMDFHASGAEKLLYPFHIIYSGEARRKMRQVIDRFHPDIIHFNNINFQLTPSVILAGAEKNIPMVQTVHDLQMLCPNHMMMEFGTWKLCEECSGKKCKMACVRKKCIHGSRAKSLIGAIEGTIYTSSHVYDRVARYICPSRFIEEKLLTVPRYAGKTTMIHNFLSKTAEIDVPKGDYVLYFGRLSEEKGIDRILAACRLLPEIPFVIAGGGPLEELCRTCGLPNVRFVGFKTGKELQELVAAARFTLHLSLWYENCPLALLESQSLGTPVLCNRIGGMPELVEEGKTGILNDTFTPEAYAEKIRALYSDSALLEEMARNCRAKKERMMTLDRYCDRLLAIYMEEIGGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8D9</accession>
    <name>R7I8D9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47563">
        <property type="protein sequence ID" value="CDE47563"/>
        <property type="gene ID" value="BN770_01284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="129" mass="14641" checksum="03A3B1C48A65D3E6" modified="2013-07-24" version="1">MGRIETALIRHYLKPTVTSDLPGRLRLSFKGYQMLPKEALPYLHYVQDVMTMLPGVRGAQVNPRIGTALVTYDASMTNREEILRWIATAVDTGLELAQEIDWTRSDVGEEELATMARRRLALRLGQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8N6</accession>
    <name>R7I8N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47851">
        <property type="protein sequence ID" value="CDE47851"/>
        <property type="gene ID" value="BN770_01388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="29" mass="3438" checksum="830BC0A84859A618" modified="2013-07-24" version="1">MRVRMVCVKVPKPLRGVVRFLVKKRRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8T6</accession>
    <name>R7I8T6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48264">
        <property type="protein sequence ID" value="CDE48264"/>
        <property type="gene ID" value="BN770_01610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="9">
        <location>
            <begin position="742"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123330" checksum="4AB219544D4212EC" modified="2013-07-24" version="1">MTTVEIWGARAGQTQSRLFEEIRQCREAGQRVLLLVPEQYTLQAERELVEQLNLPGLLDLDVLSPRRLGRRIRESAGHSPKAALDESGRRMALAQALSLKQEELHYYRRVALSPGLPEKLSTLLMDFQRTGLSSEEFAAYAEELPSGALKAKAHDLLLLWQTYDVLIAERFQDESTQQFELVERLPESGLMRDAAVFVYQFDMLPTPLCVLLATAAPECTRMVVAFTMDKDTASDGHVFTSQRRSAAELTGWLRQRGIPVQWKWLPSEPDERDEALRHLEAHLFARDGAVYPGDASALTLHAAANPYAEAAFAAQTLQSWHERGIPWQYMAVALADAQSMAGILAVTLQSAGIPCYQARKDSAARHGLSRMLVGALRCISGGFLRADVLQVAKSGFSSLTRDEADSLENYAITHGINRGKWLRPFPYGDDAADMDELRVRLISPVEALRDALRRAKTAGDSVEAIFRFLEDTNAYDRLMAREEALLSRGMAAEATQNRQVWTILMTLLDQLYALLSTQKANQRDLARFVESGLTGASISSLPPQPDTVMIGEAGHLMTGRIDALLVMGMQDGALGSTADSLLSETERRTLCDLAQRAIGLTQQETCALRQSDFYRTLSLPRRFLTVTCSQGGQDGTAFRPAGLLEDMTQLFPHMVVSGGVLANDVAPLSPAMALDALPHHLRQAVDTDTPLSEQWANVLRWLYFDPEWHSRCQAVLDALNRHGTAIFLSRDHTRRLFTQDKVSISRLEGFAQCPYRHFVNYGLKPVIRREYEFDPADVGDFYHAAMEGYAALALKEPDFPDLPDEKIHALMDTVLLPLTTAWADGPLNETPSLRLQGEKYRRTVHRAAWMFTHHAQHSRFRTVGEEVVFGEEDGLPPVVLTLHDGRKIALRGKIDRIDRWEGDEGVYLLVSDYKSSHRDIDPTRLWYGLQLQLLLYLQAACEGLDGNPAGAFYFTIQDPMVDTADVKESAEKAIAKKLHLKGIVLADVDVVEALDSNPGYSFTKIFNADSSVASSSDGYTSEEMAALLAHAKQMAAKLADRIRSGEITPSPAVIRDWNACQWCDCAGVCKLDTSIPGHEKRELPPLKKQDLLTLMANDTDAPGSEEDTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8U3</accession>
    <name>R7I8U3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator PadR-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46937">
        <property type="protein sequence ID" value="CDE46937"/>
        <property type="gene ID" value="BN770_01082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="108" mass="12046" checksum="6EE77F8964ABB287" modified="2013-07-24" version="1">MALSADILRGYTDTIILHQLSHGDSYGYQINKTISTLSGGEVELKEATLYTAFRRLEAAGLIQSYWGSETSGARRRYYAITALGQEKLISDLAAWEDTKRQLDQLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8W4</accession>
    <name>R7I8W4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47941">
        <property type="protein sequence ID" value="CDE47941"/>
        <property type="gene ID" value="BN770_01441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="187" mass="21426" checksum="CB43857A4F556AF1" modified="2013-07-24" version="1">MQQALDSPAAAKGLDDSYQPVPDVRDDPVYFARLYDQYATDVLRVCYFYLSDREKAEDVCQDVFVRLMTTHPLLQPGREKSWLLKGALNRCRDLWRGAWLKRVILGGPTFELIPAPDEFSRRDDQQAMMAAINQLPATFKEVILLHYYQGMNIAEIAQMLELPEGTISSRLSRGRKKLESILLKACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8W6</accession>
    <name>R7I8W6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48055">
        <property type="protein sequence ID" value="CDE48055"/>
        <property type="gene ID" value="BN770_01514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033072">
        <property type="term" value="P:vancomycin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="1">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="427" mass="47588" checksum="0D80C4AC369EA534" modified="2013-07-24" version="1">MKITMITLGSTGDVRPYMLLGRELHERGHEVTIAAFAPFQGMIEEAGMSFYPISGDVVDMMGRLLQPDAVGVRYLKEFEKGIRDIAPMLLDDLLHCAEGAEAIVCTFFGTMFYSIAEKYDIPCIQTQYFPMDPCKDMPISSAPFRKLGKWWNVLSYRIGYLLISALEHRYLSDWRKENDMAKRRVRLRPDYDVLGKQVPVIYAMSPTLVPRPEDWADNIHMSGFWWDERPVDYTPDPALAEFLRAGDEPVYIGFGSMVSGDMGELAEIIRQAVKLSGVRAVVALGWGQQEAKTKDANIFYVKSVPHDWLFPHMAGAVHHGGAGTTATSLRHALPTLVVPFGGDQPFWAERVYAAGCGPKAIPRDKLTAENLAEGLRALISNPEYTRNAACIGEALRNEHGCANAADLIEKAVWDWKNGNPAQDGMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Z0</accession>
    <name>R7I8Z0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase family IA variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48080">
        <property type="protein sequence ID" value="CDE48080"/>
        <property type="gene ID" value="BN770_01531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="210" mass="23373" checksum="DC788E37BEBCBFB1" modified="2013-07-24" version="1">MTILWDWNGTLLSDVPLVVKINNEVFAHHGYRLTSEEEYRRIFRFPVKDYYTDIGVTDEDFPLVAKEWNEGYVANFHLAQLHQTAAEAVHRFHDAGFHQAIISASQVDQLRAQVVKFPELDGMFDDILGLGDVYAVSKVQLAKDYLSRKGYDPADTVFLGDTSHDAEVARAIGCRCLLISGGHQCDAVLRQVPGVEVLPSLRAAADVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Z5</accession>
    <name>R7I8Z5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48085">
        <property type="protein sequence ID" value="CDE48085"/>
        <property type="gene ID" value="BN770_01534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="352"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="385"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="600" mass="67087" checksum="056D5EC21FB1BDA0" modified="2013-07-24" version="1">MARNKFDVDERLETPFDFRHLKRVGVYIGKHKWKMLLALLLSALASVTSLAVPKITQTVMDVAVPQKNVDLLLKMALAFMGIIIVGIVFTVIRSRIMAFVSQQIIYDIRKDLFAHLQQLPFAYYDSRPAGKILVRVINYVNSVSDILSNGIINSILEIINIIFIVVYMYTTEPTLATIVVAGLPIFVAIIIILKPRQRRAWQNQSNKNSNYNAYLAESIDGVRVSELFARQDVNCSIMQRLATACRAAWLKAIYISNSVWLSSEIITQIVFTLMYYAGVYWLGGAVVSFGVILAMGQYVSRFWQPITNLANIYNSFVNNMAYLERIFETMDEPVVIDDKPNAETLPPITGAVDYNNITFGYEEGQTVLKDVDLHVKAGESIALVGPTGAGKSTIVNLLCRFYDLRSGSITLTDESGVKHDITDVTLHSLRSQMGIMLQDSFIFSGTILDNIRYGRLDATDDEVRQAAAVVRADDFIREMPQGYKTTVNERGGSLSQGQKQLIAFARTLLSDPRILILDEATSSIDTKTEKLLQDGIQALLKGRTSFIIAHRLSTIKNCDRILYIGNQGIMEAGSHDELMAKRGAYYELYTAQARDQGMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9C1</accession>
    <name>R7I9C1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48479">
        <property type="protein sequence ID" value="CDE48479"/>
        <property type="gene ID" value="BN770_01717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33360" checksum="0550FA559A669FFD" modified="2013-07-24" version="1">MKKLHISMAGKRAVNGYLFILPWLLGFLLFYVRSLYMTVEFSLSDLTVLSTGGYNLEFVGLKNYYEAFFSHASFKQTLTTSIGNMVIDVPLIIFFSLFVAMMLNRKMKCRGLVRAIFFLPVLLGAEAVSNALSLAAQMMAGGLSGTSADMAAASASSGTMNMDYLIDLFAQLALPDVVLDYIVGAVSRISDIIQASGVQIVLFIAGLQSIPSSLYEVAKIEGATGYETFWKVTFPMVMPHIITCTIYTIVDAFSKSEVVKLAYSTAFTESRYGLSSAFSVVSTLITCALLGAVVYFIGKRTFYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9H8</accession>
    <name>R7I9H8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000112">
        <property type="protein sequence ID" value="CDE48544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48544">
        <property type="protein sequence ID" value="CDE48544"/>
        <property type="gene ID" value="BN770_00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="73" mass="8384" checksum="F3851FE6E04A41F6" modified="2013-07-24" version="1">MLTWECLVDTVRDDLPFILSVSTGCAISASCLEKRKHFYLRVALTILLTFCWMYGTRPYVGLNIEKVIIKGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9R3</accession>
    <name>R7I9R3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000090">
        <property type="protein sequence ID" value="CDE48221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48221">
        <property type="protein sequence ID" value="CDE48221"/>
        <property type="gene ID" value="BN770_00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="188" mass="21054" checksum="58F7F9ED15160364" modified="2013-07-24" version="1">MPPACRFTREQIVAAALAITRERGFDAVTARAIADTLHSSSKVIFSAFSGMDDLLAATIDAADAQYRAYSADFVRDSADPPYKAVGTAYIRFARNEPNLFHLLYMRDRRREDHSGDAENIAVLVDFLMTKLSLTREDATLLHIEMWAYVHGIAVLCASGQQNWDDALISRMLTDGFEGIKSRFQKNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9R8</accession>
    <name>R7I9R8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48335">
        <property type="protein sequence ID" value="CDE48335"/>
        <property type="gene ID" value="BN770_01659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="105" mass="11632" checksum="EE34FD70CE089E71" modified="2013-07-24" version="1">MLDVTPENLARLLPSDTEMTERVTTLTPKQARKPLSRLCWIGTTSRGLLVIELRNPLCVSGASLTSVPDGAGRLPFTFLAQSDRPGDVNLPARLYWWKEETHDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9S0</accession>
    <name>R7I9S0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000090">
        <property type="protein sequence ID" value="CDE48226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48226">
        <property type="protein sequence ID" value="CDE48226"/>
        <property type="gene ID" value="BN770_00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="208" mass="24516" checksum="CE05F73E3DA13281" modified="2013-07-24" version="1">MCRFLLQDGLSVEILQSLSFRTNLGLSLKNSLAHFTKAALLHEIEEISVWYDEHEALEQLALDYRVKSLESASHKYDRYFPDRPTAKVFNDLLGFRSLRDDYDEILKNPPPDALRIVNMSHGKANDDGYRGVHVYYQLDNFHYPIEIQYNTYFDRQLNNWLHKYLYKKQYPLAVGAQMRALYEQGKIKNEAEFQEVLSDVLRCGKERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA72</accession>
    <name>R7IA72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000101">
        <property type="protein sequence ID" value="CDE48381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48381">
        <property type="protein sequence ID" value="CDE48381"/>
        <property type="gene ID" value="BN770_00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="285" mass="32099" checksum="C0B29F79A4439F92" modified="2013-07-24" version="1">MKLARVSSNKGSLSRNAKTQTQGKNMVRDRISFASRLKELRMIAHISQIELAEQLHVSRAAVANWETGRTRPDIANIPALCSLLDISIEEFFSDSSDPDSNAELRLLSSYRKLPSAHRAIVLSMTEQLLAAERSTRIDPQNVQEMQIELVQLPMADDAVAAGFNLDDFSAHCKQVYLHSSPITRRADLIFHVNGDSMEPAFPNQSYVLVKRDDAPRYGEVGIFQVDNALFIKEYRKDGLASLNPKWPLMQKDHYGSIQFVGRVVGLLDEHAFATREEIITFTQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAA1</accession>
    <name>R7IAA1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ig domain protein group 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48804">
        <property type="protein sequence ID" value="CDE48804"/>
        <property type="gene ID" value="BN770_01823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="PTHR23019"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435625" evidence="6">
        <location>
            <begin position="31"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="226"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="313"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="397"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="485"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="571"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="658"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="741"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="843" mass="86885" checksum="3614DC223001E403" modified="2013-07-24" version="1">MKQSMKKAALVLMLALAVLLVPQWSNTALAVTTPSDITTGSDLPPAPPLPTPPAKGEVVISGAKTVRGGEKLTFSVTIDGKTVPNSDLEWTLYPADASLATIKSGVITTKRVAYTHYVQVSAALKSDPSRYANFRLCIAPGVKKITVSAPTMYVDLSGSKTLQLKATCDPEDAIADVTWSSSSSKIATVDASGLVTARKTGKVTITATAKDGSKVKGRITLRVVSGVTGLTIEGAGSVAAGKSITLKAVMTPADATEKGVVWSVDCDKSIASISQSGKLTTKKVSAITTITVTAVSKQNSAIRATHTVTIRPVTTGLAISAPRLTIDLASPTLQLTAKCIPEDASQQVAWSTSNKRIATVDANGLVTAKKVGKVTITAKATDGSGRSAKITLTVGSAVGTLEIRGASAVAQGKTITLNAVITPATATNQKVIWSVDCGKDIATIDRHGRLKAGKGFTAPVTITVTAVSAENSAISATRTVQILPPVTTVAISAPRNYIDVDGEDKTLQLTARVLPEDAAQSVTWSTSNKRIATVDANGVVTALKAGTVTITATATDGTGVRAKFTVKVQKTVKSLTISGAEKLGGGQSTTIKATILPKDAANQKVIYSLNCPASVATISTSGVLTTKNVAEITTVTVNAVSAENSTISATWTLVIYPKTTKLTLTAASSWVNVGASMQLHVSATPETAQMPIRWRSSNTRVATVDANGVVRGLKAGTATITVRTTDGSNKRASVRVTVGIPATGVVITGNRIVRAGATLRLMATVQPANATVKRVTWAVNCPANVATISGDGKLRVSANAETQIVLVTATVNDGQRVSAAYPVYIQGKAPVPPTPTTPDAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAC4</accession>
    <name>R7IAC4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000112">
        <property type="protein sequence ID" value="CDE48545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48545">
        <property type="protein sequence ID" value="CDE48545"/>
        <property type="gene ID" value="BN770_00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="233" mass="26343" checksum="EA42A624ED9D2DC6" modified="2013-07-24" version="1">MLRIAIVEDHESDAKRLTALLEAYAQKNGKRFAITWIANANTFLDSYQHQYELVFMDIRMPGLNGMMAAHELREMDHTVVLVFLTSLAQYAVESYEVEATDYILKPITAAALDLKLPRILNRCMVESEEEVVIQSGGTTTRLRPNELHYVEIYDHHIQFVTASGIMRSYGTLKAVEDALPDVFFRVNNQTIVNLRFVTHVGSNDATVAGHTFPISRGRRKEFLSALHLAGMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAF6</accession>
    <name>R7IAF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NHL repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48476">
        <property type="protein sequence ID" value="CDE48476"/>
        <property type="gene ID" value="BN770_01714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447733" evidence="4">
        <location>
            <begin position="27"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="919" mass="99928" checksum="3C183D54653228FD" modified="2013-07-24" version="1">MKKMKKFLLTALAALVTFSSCGGALADAELPYTTYNYDYWGYIVYTPAAYVPAGSITGTSFQYNGQSLGAFKNPQDLCVAQDGTVYLADSGNNRIVLLSSDMTKVVRVITGFENHGVADTFQTPTGVAVASDDTLYIADSLNRRVVVLNPDDTLNRIIEIPQLSGSVKALGGVTYAVGTHIEGMGDLNQETDVDGMKYRTERFTSGSATELADEQGTTYQVSAYESTLQPLVKAVTDSKGATYAIAENGKSVIRTNADGSTFTYARYDATTNIDLFILIGRLIKGNQNITGMSGLIGLALDEQDNLYCISAKTVVVLDQKGNMVTTYGNYRNADDALTSFATISEFALDGDSVFIRDADNHIVELDRTGSTRRVIESNCIRKTDADGNITRMTGMAGAAAASSEDEETAFQNILGIELTGDYLIVGEKNGEINVMKTTGKLLGTVENNSLLLLDTKTDSVSAVTTVKNGKQDERLTEVSATAMVDWNGTQRLCVKESTGRVLVLDDNWTVLHTAQNNCVEVQDRNGAVTERILGVDVGSGYQAFAEVSGVEGVALNSASQLCIADSDNRLIVLDGDKNVARVTVNPNSEVLDANFLFTPLKVSVDYAGRVYCIAQNMFEGIMVFETNGDFTGFFGTISVEITAWEKFWRKLATKEERSKQQLFIPTEFTGIDIDDEGFVYASNKDTAGTQAVRRLNPKGEDVIRMGQTKNLGGDMQISGTSQYAGASTIVDVVYREKGIYSLLDSKRGRIITYDHEGNLLYIFGGLGTQAGTMEAPVAIECAGDKMLALDSKQGVIAVFGETEYGRLINEAVGLRYDGDETQAVALWQEVLRMDENNELANTGIGKAYLSAGDNEKAMEYLKRGMNRDYYSVAFKRYRNDVLKSNINYILTGIIAVIVAIVVVVKVIRPRRNQKNGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAS5</accession>
    <name>R7IAS5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain-containing surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47607">
        <property type="protein sequence ID" value="CDE47607"/>
        <property type="gene ID" value="BN770_01313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="299" mass="31931" checksum="46C343A6B4F63DAC" modified="2013-07-24" version="1">MQCGDYTYRAIDTGAEIMEYYGQGGEITLPETLDSLPVVSVGLCAFIMRTDLTAVTLPKTLRHIGGSAFEGCSALTSITLNDGLETIEYRAFASCTALREIAFPDSVTTVGGAVLSGCTALNSVHLPNTLTVLPMQALMNCTSLEFLNLPDTLTRIDHEALRGCTHLTALAIPASVREIGHDALTGCSRLNALTLPAPFSARARDLRVGLGLMTEGDTLIVGSYLGQAEKGSTYSVIEYIGSDTELIIPAFIEGCRVTKFNQRILEDMDSLRILSVPAGFVVEPTLVPEGAQVVVRPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAY2</accession>
    <name>R7IAY2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49064">
        <property type="protein sequence ID" value="CDE49064"/>
        <property type="gene ID" value="BN770_01907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447748" evidence="1">
        <location>
            <begin position="25"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="73"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="35542" checksum="02952CD936C451BA" modified="2013-07-24" version="1">MKKIQKLLLLLLMMAMLLPTFAMAETPVIVNLVENPDAEYHFEDGAKILEIVFPRVYSSDCILLRYDGMVMMIDASTKNATMRNRIYTACDTIGIDHIDIAYNSHPHDDHIDGFQFVNEYAPISKFLITFPEDFNARMKSAVKFMKANNIPIEQIGNGDTFTLGEDGGVKMTVIQNHKSSWGVNDQSAMLMVQYGDRRMLFAGDNENRSQQYFAANPPEIGLNADIFKYPHHGQVRLRDDFLEAINPQLIFINGAANVIKGSVNYCDKKHISYLLGYKGLTRMRTDGHIWVIDYLKEKNADRDLPYTPERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB01</accession>
    <name>R7IB01_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage V sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000057">
        <property type="protein sequence ID" value="CDE47682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47682">
        <property type="protein sequence ID" value="CDE47682"/>
        <property type="gene ID" value="BN770_00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014203">
        <property type="entry name" value="Spore_V_AC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005562">
        <property type="entry name" value="SpoVA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38450">
        <property type="entry name" value="PTHR38450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03862">
        <property type="entry name" value="SpoVAC_SpoVAEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02838">
        <property type="entry name" value="spore_V_AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="158" mass="16928" checksum="1E6DCF489CE14344" modified="2013-07-24" version="1">MFEKDKQPSPTRQRQLDRYARLVDILSPKSKMGQGLIRAFWVGGVICVIGQCCMEAGLAWLDMTPSTASTFASMVLVFLTALLTGLGVFDKIGQYAGAGAFVPISGFANAMVSPAMEFRREGMVLGLGAKLFTIAGPVLVWGTSASVLVGIVYALFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB72</accession>
    <name>R7IB72_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThrE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000138">
        <property type="protein sequence ID" value="CDE49164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49164">
        <property type="protein sequence ID" value="CDE49164"/>
        <property type="gene ID" value="BN770_01925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="14"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="27643" checksum="6D623236529E43EF" modified="2013-07-24" version="1">MFDDSCYMEPLHLAGRLIMENGGETCRVEETVLRMGHAFGFREVECFAVPSGLFVSYRKSDGTIETAVKRIRRKGIDLTRIDEVNAISRHLEQEKMSCQEVLSQLKAVERRPFRLSPLQMAGAAAMSTAGWSLMFGGGVWDMVTAFFVGLLIEWVTLLMDKFHMQTLVATLAGGFLAAFLPMAVNRLTGALVVEAAVAGALMPMLPGLAMTNAVQDTMRGDMVSGISSAVSAAMSAVLLAVGALAGTAFLRLLTGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB79</accession>
    <name>R7IB79_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage/plasmid primase P4 family C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000114">
        <property type="protein sequence ID" value="CDE48568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48568">
        <property type="protein sequence ID" value="CDE48568"/>
        <property type="gene ID" value="BN770_01727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014820">
        <property type="entry name" value="PriCT_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00885">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00942">
        <property type="entry name" value="PriCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="2">
        <location>
            <begin position="478"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="761" mass="86304" checksum="F9819CF308101933" modified="2013-07-24" version="1">MITIYSSDSIGVRGNCLYPYRHEVMDAAGLREAVKHDYVCAEYKNSYRSGGNFITSNCLGMDCDNDHTDHEHEWITPDDVRRNFPDVPLAIHFSRHHMKPKDQKSARPRFHCLFAIEPTTDVKAYADMKARLNALFPYFDAQALDGARFFFGTDDPEVDFFPGTITLNECLERYYPEEDSFANLPDGTPQGRAVIQEGSRNRTMSVFAGKILKRYGDSDQTHDLFLQEAAKCDPPLPDEELATIWRSARSFYQRIRSQPDYVPPEKYNADAPDDFAFRPADDTDVGEARMLADVFYERLRYSRATDYLCYDGICWNEDIPGAHRIVHELTDLQLAEAEEAMNAAWQVLLNNGGAELVETLSAKKALAAMSEDQQKAFAWYNVTKRYYQLAMSYRASKNIRYVLNEAPALLLISPQELDADPFALNTPAGTLDLRHGLTSIRDHRPEDYVTKVTAVAPSDEGTELWQDALNTIFCKNPELIDYVQLIAGMSLVGRVFSETLIIAYGDGRNGKSTFWNVLARVLGSYGGKISADALTVGCKRNVKPEMAEAKGKRMLIASELEEGMRLNTSIVKQLCSTDPIEAEKKYKDPFHFEPSHTLILYTNHLPRVGAIDDGTWRRLIVIPFAAKIEGKSDIKNYADYLFTNAGGAILKWMIEGAVRVIEAEFRIDLPVCVQEAIKAYRGENDWLWHFLTDRCDIGKELNEQSGALYTAYRQYCAECGEYTRSTTDFYTALENEGFVRQRTRKGSVIRGLMLRTDDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBF5</accession>
    <name>R7IBF5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="7" type="ORF">BN770_01825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48806">
        <property type="protein sequence ID" value="CDE48806"/>
        <property type="gene ID" value="BN770_01825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="187"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="298" mass="33005" checksum="F8615D2F1FA7A31A" modified="2013-07-24" version="1">MGLFAKLREGLTKTRDSLMGRVDTLVKETRKIDEDFYEELEDILLMSDCGMKATTAMMDELRRRVSENKVKDADTAKQMLKDIMIEQMDIPRPPLRWPMVMLVVGVNGAGKTTTIGKLALRFQNIGRRIILCAADTFRAAAADQLTVWAERARVPIVKHAEGADPAAVVYDGIQSAKAQGADLLIVDTAGRLHNKKNLMDELNKMRRVIDREFPEADVRCMLVLDATTGQNGLAQARAFKEVCEIGGIILTKLDGTAKGGIALAIRQELEVPVWYIGVGEGIDDLQPFNAKDFVEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBI1</accession>
    <name>R7IBI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49234">
        <property type="protein sequence ID" value="CDE49234"/>
        <property type="gene ID" value="BN770_01950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glyco_hydro_2" evidence="8">
        <location>
            <begin position="186"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase_ig" evidence="10">
        <location>
            <begin position="662"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_mannosidase" evidence="9">
        <location>
            <begin position="749"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="818" mass="93765" checksum="2C6F9F64D9E0AF07" modified="2013-07-24" version="1">MTEQVNLGGAWRMREADSETWHSAHVPGSVYADLTADGTMPDPFWRENELDAFERMKKDYVYQRAFTVTEAQLAHAHVELVCEGLDTLAHVSLNGREIAFADNMHITWVWDVKEQLHAGENTLEIRFDSPILYCAKKAEEAPGWESSDATPGFRHLRKAHCMFGWDWGPRLPDAGIWRPIFLRTWDTARLENALMLQAHHDGVVDVTIRPEIAGESAWSAEITAPDGEVLTLPETMAAEQVIAIQNPQLWWPNGLGKQPLYRVTVRLATGDTRMWRIGLRTMTVSREKDEWGEEFCHVVNGMKVFAMGADYIPEDNILARVTPERTRRLLEDCKAANFNAIRVWGGGYYPDDAFYDICDELGLLVWQDLMYACAFYDLTPDFERSIRVETHQNVARLRHHASLALICGNNEMEMFMAGANSALINHRTWEFVPTYPHHITDYVKMFEYILPAIVKETAPQTYWWPASPSSGGNFDAPNDENRGDNHYWDVWHGEKPFTEYRKFFFRYASEFGFQSFPCLKSVKQFTLPDDRNIFSRVMERHQRNQAANGKILSYLSQTFRYPNSFDDLLYASQLMQAEAIRYGVEHWRRNRGRCMGAIIWQLNDIWPVASWASIDYYGRWKALHYAAKRFFAPVMISAEEEGELSQNPKINEYHPAPLEKSFRLNVCNETLRDVTGEVVWALRTPDGAIVRQNQQTLTIPAMSAKWLDKVDCADASLTGHYVSFAFVVDDVALSEGTCIFCAPKHFEFVDPRLTLETRGDTLVVTSHAYAKQVWLESEDADLLLDDNAFDMNPGTKVVRVVQGSAEKVRGRSVWDLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBJ4</accession>
    <name>R7IBJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48678">
        <property type="protein sequence ID" value="CDE48678"/>
        <property type="gene ID" value="BN770_01787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="66"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="185" mass="21483" checksum="037C5B0B7781D5FF" modified="2013-07-24" version="1">MSAYINRYFLLMAVFLPLWCIIRRPWKRWSLHEGCLMAFAALLFSLLCLVLRGTWAAPGDMLASALHRLRTGEGIQLRLFRTITRQLRYARHEEMLINIWGNILLFIPYGFFLPLLWKRYRHPLQLSLMCLLLPLSIETCQLFIHRMTDVDDVLLNFAGGMIGGGVFALVHMVFPKFTDKALVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBP1</accession>
    <name>R7IBP1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rex</name>
        <name evidence="9" type="ORF">BN770_01435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47922">
        <property type="protein sequence ID" value="CDE47922"/>
        <property type="gene ID" value="BN770_01435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="89"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="213" mass="23935" checksum="92432B85C3995788" modified="2013-07-24" version="1">MAGHVSDAVIRRLPGYYRHLRELESAGVEQISSQELGERMHLTPSQIRQDINCFGGFGRQGYGYKVSDLKMHIGEILGLDREHTEIIVGAGNIGCAIAKYPTFQREGFRPLAMFDNDPEKIGVPVGDIPVYSMEEMPNFLKENMPDIAVLALPRRVAQEALDKLYACGIRAVWNFAPTDLTHPDDMLVVNVHLTDSLQTLTYHMAHRNEENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBU9</accession>
    <name>R7IBU9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_01806</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48748">
        <property type="protein sequence ID" value="CDE48748"/>
        <property type="gene ID" value="BN770_01806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="391"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="630"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="765"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE48748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="906" mass="101185" checksum="B4FE96EE2B3E4D39" modified="2013-07-24" version="1">MTQGDERMKAAKASIRQRLTHSKLPMLVLVGVVLFALIFLGMRFFTRYTREELYRESQNQLTEITSQMYEKLSITLEQQWDFLTVMDRSVAFYAPTTQEALVQLLQATQNQLMSQDSALRFLAIDESGNLINAAGERMPCEFADTLGMTGRQCFLIRGKGGDENQMVFSLPIMQPLKVAMGEKSIRITHLVLLKGMSSLTPFFRSSAFHTQNSTYVVISDGVKMYSDAADENINFLGRNIYPALRTLRYPHAGNFDNCLTELEASDNHFTCTDVLVDKTQYFLCMKRLTGCDWTMLFLVPGVEVAAGARAMVDSITLIVNIAFFVLLLLTVGAMYFLLTAMQNRERYAVETENAQALAQANAELDQARQAAVDALKLAESANVSKTAFLTNMSHDIRTPMNAIIGLTNLMQHDLNNPEKLQAYIDKLHTSSEHLLGLINDVLDMSKIESGAVTLRMDEVNLAEQIEQIEAIIRPQTRQRGQHFIVRASQIHHENFIGDATRLRQVLLNILSNAVKYTQQGGEISLDVREVSRSGHSYVKYAFVVKDNGIGMTEEFQKHLFDVFTRAEDSVTNKVQGTGLGMAISKSIVDMMGGVINVESAPGEGSHFEVLLEFKVDAQADDRAHTVKDCHLLLVGYAPGRVADVQDALEHTPVTAEAVERPEDAVNMLRQEDVDVVLLSCQYRAPEMLRPLVRQMREAAGKPIFVFCMQAGQREEVLDIISACGLDGFVPLPFFLSNLENEMAKLRTEFGNIGNVDGTSVLNGMRLLCAEDNPLNAEILEELLHMQGATCTIYSDGKQLVEAFDHVRPSDYDVILMDVQMPVMNGYEATRALRASDNPVGRTIPIIAMTANAFADDIQQSMDAGMDMHLSKPIDIAVLEKTLSLFRTDKKNHGRAVFKRRVMEMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC21</accession>
    <name>R7IC21_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">BN770_01511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48052">
        <property type="protein sequence ID" value="CDE48052"/>
        <property type="gene ID" value="BN770_01511"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="403" mass="44958" checksum="58594496C4067A1C" modified="2013-07-24" version="1">MAKMRVLLAYSGGLDTSIIVPWLKENYDCDVVCVAGDVGQGEELEPLHEKAKKCGAEKLYIEDLRKEFVEDFIWPTLKAGAVYEGKYLLGTSFARPLIAKRLVEIAHKENCTAICHGCTGKGNDQVRFELTIKAFDPNMQIIAPWRIWDIKTREEEIDYAEKRGIPVPVKKDRPYSMDRNIWHISHEGADLEDPWNEPPEDLLLTMVTPEKAPDQPEYVTVDFEKGVPVAINGEKLDAVDLLTKANEIAGRNGVGCADLVENRLVGMKSRGVYETPGGTMLYAAHGILESITLDRATSHYKELVASKFAELVYDGMWYTPLREALSAFVDSTQQAVNGTVKLKLYKGNCINAGVKSPNSLYMEEIATFGDSHDLYSHKDSAGFINLLGLPLKVKAMVEQKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC26</accession>
    <name>R7IC26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48057">
        <property type="protein sequence ID" value="CDE48057"/>
        <property type="gene ID" value="BN770_01516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="367"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="400"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="619" mass="68896" checksum="AEFEDD3F40E9F2AA" modified="2013-07-24" version="1">MQSFQEQDYTKRFDLSLWRKLIKVAKPYHKNLIAVVLFMAVSAIIDVIMPNMNAYAIDVFIANHSTAGLVGFVVAYALLTAVQVATIFGFLRQCGIVETGTCYLIRKLGFQKLQELPFSYYDRMPVGYLMSRLTNDTQRLADTIGWSLVDLCWGAVYLVACAVRMLTINWRLGLIVMLVLPPLAVISWKFQKAILAAYRQVRKNNSQITAGFNEGINGAKTTKTLVREELNIQEFETVSASMRSASIRAATLSNLFLPIVVSLGSLATAYALWQGGNSVIGGTHVFGVAMTVGTLTMFINYTVSFFQPVRDIARIFAELQSAQAAAERVISLLETEPDIVDSPEVVVQYGDNFHPKTENWPKLIGDIDFEDVTFRYKEGEKVLEHFNLHIQHGQTIALVGETGSGKSTIVNLVCRFYEPTEGKILIDGADYRTRSQLWLQSNLGYVLQSPHLFSGTVADNIRYGRPDATDEEVAEAARMVGAEPFIRNMKDGYQADVGEGGNRLSTGQKQLISFARAILTNPSIFVLDEATSSVDTETEQLIQHAIQKVLAGRTSFIIAHRLSTIRSADRILVIQNGKITEDGTHQQLIAKQGYYYQLYTNQFQEEQGLEILDGAMARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC31</accession>
    <name>R7IC31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48062">
        <property type="protein sequence ID" value="CDE48062"/>
        <property type="gene ID" value="BN770_01521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="223" mass="24131" checksum="F9F33A5488A00177" modified="2013-07-24" version="1">MSMTWERLGSMLLEETGNTLLMTLPATFFAYLIGLPLGVLLVITRKDGILPKPTLNRIIGVIVNLLRSVPFIILMVMLFPATRAILGRGTGTVSIIIPLTVSAFPYVARMVEGSLLEVDNGVVEAAQAMGSTTFQIVRKVLIPEAMPSLVNGFAICITTILGYTAMAGTAGGDGLGKVAITYGLNKRQYDVMYAASIVLVLLVQFFQMGGTWLSHAIDHRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC55</accession>
    <name>R7IC55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000122">
        <property type="protein sequence ID" value="CDE48873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48873">
        <property type="protein sequence ID" value="CDE48873"/>
        <property type="gene ID" value="BN770_01850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="155" mass="16642" checksum="9330CE32D6F1E557" modified="2013-07-24" version="1">MTEIALIAKILLDLFLRTKCGYLLRAAGDNPSVVTTLSRDQGTVKILGLIIANALVALAGAVMCQQQRFFDISMGTGTMVAGLASVIIGTNLFRHASFLRTTTMVLIGSILYKACVSIAISFGLDAQDMKLITAVLFLAILVLSNTRKKKVRIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC76</accession>
    <name>R7IC76_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48107">
        <property type="protein sequence ID" value="CDE48107"/>
        <property type="gene ID" value="BN770_00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="111" mass="13570" checksum="717F3652C91BE958" modified="2013-07-24" version="1">MARKCTEYHYFQHTYWDVMARYNWMRCPYCGKLCKPSRFKAATVLVPIELVIFVVCIFFRNSMNDAIGWFAAWLLFVLLLFLPHYIYVRFFMPYETLSEDETRKFHELQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICY7</accession>
    <name>R7ICY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49261">
        <property type="protein sequence ID" value="CDE49261"/>
        <property type="gene ID" value="BN770_01955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="161" mass="18093" checksum="5E71CD72943F1690" modified="2013-07-24" version="1">MFNVIPFRAARNLMNTSMDDMLSDRFFRNFFDMSDMVGTAGFRVDVKEQPDAYVLEAELPGVKQDDITLTAEDGVLTIAADINSEKKDNREGYLYSERRTGHVERRFSLEGVREDDITAKCEHGILTVTLPKMQAEAPKAARKIAIASGEEKTDAPVEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDQ0</accession>
    <name>R7IDQ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="5">3.4.25.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hslV</name>
        <name evidence="6" type="ORF">BN770_02044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Allosterically activated by HslU binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49571">
        <property type="protein sequence ID" value="CDE49571"/>
        <property type="gene ID" value="BN770_02044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00248">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="179" mass="18893" checksum="A497ED762190C860" modified="2013-07-24" version="1">MSMELRGTTICAVRKNGHTSIAGDGQVTMGQSVIFKSHAHKVRRLYGGQVVIGFAGAVADAFTLCDKFEEKLTQCGGNLERAAVALAQMWRSDSGMRQLETQMIVADKDTLLVVSGTGEVIDPDEGVVAIGSGGNYALAAARALVQNTDLSAHDIAEKALHIAASICVFTNDNVIVEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDW3</accession>
    <name>R7IDW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GJ19447</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48737">
        <property type="protein sequence ID" value="CDE48737"/>
        <property type="gene ID" value="BN770_01797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447874" evidence="2">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="39"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="350" mass="39081" checksum="187FF9E2C1810BA5" modified="2013-07-24" version="1">MKRMMRLLSLALCLMLVQQTAFAAIPEDYVVRHGDRESKKIAITVDDGWNMDAVYKIHELSIELDFPVTWFIVGKLFCAEDRELWEDALAHGDEFGSHTWKHAQLLEYSESSADAQVRLSQERVDEVLGYHYPLRLLRPPFGHYMNSEKNFLPIFYAHGVEKVVLWDVAQTEPYQAFRDTQNGSILLYHARMVDYECLKTLIPMLRDAGFEFVTVSDLLGLEPLVLDKPDDAEATDAPEATKPPETTKAPAVTKAPKPTNPPKPTNPPKPTNPPKPTEAPEPTEAPKPTDVPKPTDVPKPTEAPKPTDVPEATDVPEATDVPEATDVPEATDVPKPTDVPEVTNPSEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDW4</accession>
    <name>R7IDW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49800">
        <property type="protein sequence ID" value="CDE49800"/>
        <property type="gene ID" value="BN770_02148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025664">
        <property type="entry name" value="Spore_III_AC/AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06686">
        <property type="entry name" value="SpoIIIAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="130" mass="13354" checksum="E3E051C05E67FA1E" modified="2013-07-24" version="1">METAGKLAGFAVCAALVALILRRLRPEAGWGVSLGAGAIVLLAALPALSALVRGIASLSAMSGLDDSFMQQLLKIAGLSLLLDFAAQTCRDAQEEALALKVEFAGRVLLLSSALPVLQALLSQLVSLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEC3</accession>
    <name>R7IEC3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_02212</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49980">
        <property type="protein sequence ID" value="CDE49980"/>
        <property type="gene ID" value="BN770_02212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="219"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="526" mass="57871" checksum="779295279D593947" modified="2013-07-24" version="1">MRFDDLKLMPLLLQNVQAAGYETPTPIQQATIPLVLAGKDVLGCAQTGTGKTAAFALPIIQQLAKKPTRFGQSRAIRALILTPTRELAQQIYDNFVLYGKKLPVYPTVIFGGVNQQGQVNALHRGADVVIACPGRLWDLMNQGFVHLDKVETFVLDEADRMLDMGFIHDVRRIAEKLPEKRQTLMFSATMPPEVEKLAMDLLHEPESVKVDPVSSTVKKIDQCLYYVDKANKKHLLAKILRDPDVENALVFSRTKHGADRIVRDLKREGIDAVAIHGDKSQNARQAALTAFKTGECKVLVATDIAARGIDIAGLSHVINYDMPMEPEAYVHRIGRTGRAGRDGTAISFCCIDEVKQLGQVEKLIGKRLPLKESEWPMEITTPSEPKPRQPRPAKLTMQGNAAPERKANRPMSAKPAKLAASAPIREVSVEKRAAKSAPREMQVIRREHQQNPVPRFGPASGQRAARSGQPVVIGRDGKMRLGGTPIRVESAPASKPVARTNASSAKKSAGQPVRRVNRSRGRNGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEC9</accession>
    <name>R7IEC9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Signal peptidase I</fullName>
            <ecNumber evidence="4 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 6"/>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50174">
        <property type="protein sequence ID" value="CDE50174"/>
        <property type="gene ID" value="BN770_02314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="56"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="217" mass="24326" checksum="04B48E35935ED975" modified="2013-07-24" version="1">MSEDKNQQKTGKQLLNDTQEAAERAHLLREMNPTSAQLETELKHEKRKHSYNRALRSTLYTLLVVAAVAVLIATMVMPILQITGTSMTPVVGQGEITMVVRGSNPQRGDIIAFYYNNKVLIKRVIGLPGEWVNIDGSGNVYINGELLDEPYITDRALGDCSITLPYQVPDGRYFVLGDHRSTSRDSRSTLVGPVSEEQIMGRVTLRIWPLNRFGFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IED3</accession>
    <name>R7IED3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48942">
        <property type="protein sequence ID" value="CDE48942"/>
        <property type="gene ID" value="BN770_01874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="104"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="247" mass="28552" checksum="8093EFB9CE420CD2" modified="2013-07-24" version="1">MTRPEADDLFREYARSRDHAVMARLVEENLPLSQAVARKFQGQGVEKDDLEQVAAMALMQAIERFDPERGLQFSTFALPTIAGSVRNYLRDRGSTIRLTRSLREQLTKLRRVSDELTRKLQREPSMRELAEAMELPPEELLTLLDARRSAQTVSLDAEMSDDAEAPRLETFLGRLDEGYEQVEQAQWLNWVYGQVTPTEKLLLQKRFEERLGQRETARALGVSQMQVSRMERRLLTRLREKMTAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF61</accession>
    <name>R7IF61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferases involved in cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50096">
        <property type="protein sequence ID" value="CDE50096"/>
        <property type="gene ID" value="BN770_02273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="323" mass="36148" checksum="BD257BB2E09A2951" modified="2013-07-24" version="1">MAHKPVLYIVIPCYNEESVLPITSGMFRDKVRQLADAGKISDESRILFVNDGSKDKTWEIITALSAKDPCFQGIAQSRNRGHQRAVWAGLMEAKDRCDITISIDCDGQDDINAMDAMVDAYLDGCEIVYGVRSKRDTDTFFKRFTAEGFYKLLSAMGAEVVFNHADYRLISSRALQELAKFREVNLYLRGMVPLVGFKSTSVSYERHERIAGESHYPLKKMLGLAFDGITSLSVKPIRMVFFAGLFITILSFIGIIWAVIAAIAGHSVAGWASLACLVCFVGGMQCLFLGIIGEYIGKIYLEVKQRPRYIISERTAEMDEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFD8</accession>
    <name>R7IFD8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49267">
        <property type="protein sequence ID" value="CDE49267"/>
        <property type="gene ID" value="BN770_01958"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="288" mass="31149" checksum="8723EE99BCB09CFB" modified="2013-07-24" version="1">MRIASILNEKEITLSCEVFPPKHFDGIAQASAVAQEIAGLHPSFMSVTYGAAGSTPGHTIAVAKAVAETGVTPLCHLTCVQSTREHVQHVLADMKTAGMENVLALRGDLPKEGEPCHDFAYAAELIDFIHQQGDFCVGAACYPEGHPESGSRAKDMDYLRRKVDAGVDFLTTQMFFDNGLLYNFLYRMQRAGMDIPVCAGIMPICDARQVARVVKLSGSIMPPRFAAIADRFAGDPQAMTQAGIAFATEQIVDLVANGVGHIHLYTMNKPWIARAIVENLSSIIKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFE6</accession>
    <name>R7IFE6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KWG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50534">
        <property type="protein sequence ID" value="CDE50534"/>
        <property type="gene ID" value="BN770_02427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447917" evidence="1">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="445" mass="49329" checksum="319E6B2403EC7C38" modified="2013-07-24" version="1">MKWWKKLCAAALALSMPVLASAEAKLVDTQTFARSITLGRASDTYVTREDWRDTLRAMDGTALSESYADISAQEKGLYYEVANENGVNQTGLMDAAGTLLIPMTYSDFTYVGNGWVVAVTLEETTDEKSDYRAMFGGGHYNVVRGDIYYGAQKMAEMNREETTGASMEVYGAYLFVRLDKSSGFYLKTDGTRTEFTGESFSRGEYEEIYKQGVYHHPTAQFAFVPECTLTADEVSRSVWYDTKTGNFLDLQGNVLREAVQDGKPLYDSVRYYGGDYMLTKKDRLSGIVDMTGQEIVPPMYDTLGGDYAGLLFEGGYQAALEGGKLRFLTRDGQVSASVDYELKENDWKGLTNNAPMIYAEMNGKISVFTATRGELPTQYEEAARGQAGQELLAVKQDGLWGCIGMDGEVVVPFVMKYAPEISFDGRYVVGSTAEGYQLFTISYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFE7</accession>
    <name>R7IFE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50063">
        <property type="protein sequence ID" value="CDE50063"/>
        <property type="gene ID" value="BN770_02264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="36" mass="4218" checksum="5B7455928AEF4146" modified="2013-07-24" version="1">MDDLFFRMRNDFDRMIQANIPGQNHDCSIIPDYGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFH7</accession>
    <name>R7IFH7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50360">
        <property type="protein sequence ID" value="CDE50360"/>
        <property type="gene ID" value="BN770_00175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="8">
        <location>
            <begin position="49"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="306"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="373" mass="40211" checksum="E756FE82792FB1B0" modified="2013-07-24" version="1">MLLRNGLFFVDGHFWENLCVRLETGRVTAMGEGLAPLAGEAVIDLQGDFVLPGFVDAHIHAFRGHDTMQGEDAIRQMARELYREGVAAFLPTTMSASVEDTRRVIAAVRRVMDTPEQRAARVLGAHMEAPFLSPEKAGAQRKEFFLHPSWEAFLDLTGGDIQAVRVITMAPELPGAEDFIRKAAENGIHVSIGHTAATDEQVHQAADWGATRVTHTYNAQTPFTHRAPGVPGAALTDDRLFAEFIGDGVHLHDDAVKVLLRCKGPDKTVAITDSMEAAGLPDGEYALGGQAVTVRGHEARLHDGTLAGSVLLMRQAFQNLMARYGQTPENAARICTENPARSIGASGFGTICVGAGAPLTRWGKDFAWKGILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFT4</accession>
    <name>R7IFT4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Release factor glutamine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50291">
        <property type="protein sequence ID" value="CDE50291"/>
        <property type="gene ID" value="BN770_02351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010787">
        <property type="entry name" value="DUF1385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07136">
        <property type="entry name" value="DUF1385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="210" mass="22916" checksum="4DCF0A9CE288D6B1" modified="2013-07-24" version="1">MPNQSQKPVDIGGQAVLEGVMMKGTDAIAITVRRPDKTMVVDYKKSEPLSKKHKWMGLPIIRGAVNMVNMLAMGMTTLETSAKMLGTEEEEPTKFEKWLAAKLGKSIDKVVMGVAMVLAVLLSVGLFIVLPSLAEKGILSLGASGTVATLIGGLTKVLILIAYMIFCGMVPDVRRTFQYHGAEHKTVYCHEHNLPLTPKNAQQFTTLHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFU1</accession>
    <name>R7IFU1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">infB</name>
        <name evidence="12" type="ORF">BN770_02417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50490">
        <property type="protein sequence ID" value="CDE50490"/>
        <property type="gene ID" value="BN770_02417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="500"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="8">
        <location>
            <begin position="503"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="509"/>
            <end position="516"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="555"/>
            <end position="559"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="609"/>
            <end position="612"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE50490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="998" mass="107965" checksum="A80F4FCC3508A23D" modified="2013-07-24" version="1">MTKVKLKDAIKDLTTDAAKVRDDASRVRQSADGLAKSLRALENGFIKSLNAKAEQEKRAEEEKRLSDHSKAYVMLDVDEQAAVNAARQEAEKAEKAERAEKQEAKSAPKQEAKAEAPKSEQKPAPKVETKPEAKAEAPKSEQKPAPKAEAKPEVKAEAPKSEQKPAPKVETKPEAKAEAPKSVQKPETKAEPKPEAPKKPAIGQIISRPGQALPPKPVGLAPNVIRPPRPQQPRPQGQQGAQGNRPQQGQPRSGGNGAFIARPQQGQPRPGGNGAFVARPQQGQQNRPGNGSFQPRPGGNGAFVARPQGARPQGGAGFQARPQGGTGRPAGVGMNRPKPAVPDMAPAMGKERVSNYDPNKKNYVRQHDPEHVARNRKQLSRDAGYSGYDDDVVRGGKRSRMKKPSAQQMMAPIKIEHAYMSGDTIVVRDLCEKIGKTSAEIIKKLFLLGNMATINSEIDFDTASLVCADFDITLEKKPEVTAEDQLTAENFDDSEENLQPRPPVVTIMGHVDHGKTSLLDYIRNSRVTAGEAGGITQHIGAYTVKMNGRDITFLDTPGHEAFTAMRARGAQATDIAILVVAADDSVMPQTIEAINHAKAANVPIIVAINKMDKPEADPERVKTDLTKYGIVCEDWGGDTIMCPVSAKTGEGVDELLEMILLQADTMELRANPNRLGRGVIIEAKLDKARGPLATVLMQNGTLHVGDNIIAGLASGRVRALINDRGEKVKEAGPSTPVEIMGFDEVPSAGDEMQAVGDDRLSRQVAEERKAKVKASREATMAKVSLENMFSNMESGKQTTLNLIIKADVQGSVEAVKQAMEKLSSDEVKVHVLHSAAGAITKDDVNLASAFNAIIIGFNIRPDASAREAAEREKVDVRLYTVIYKAIEDMELAMKGLLAPEYREVLLGHAEVRNVFKITGAGVIAGCYVTDGKVQRNAQVRLLRDNVVVFEGKLSSLKHYKEDVKEMAAGFECGMSLEGHNDIKEGDVVECFIMEEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG13</accession>
    <name>R7IG13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate synthase (NADPH) GltB1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50401">
        <property type="protein sequence ID" value="CDE50401"/>
        <property type="gene ID" value="BN770_02367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012375">
        <property type="entry name" value="Glu_synth_lsu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018774">
        <property type="entry name" value="GOGAT_lg_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="1">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="376" mass="42351" checksum="49E687F03E3803EF" modified="2013-07-24" version="1">MIDTRDSSLFGTRNPMEGEVRIPSGCAIAGIFHKKGGKIGGDTIIRAMEPMHDRSNGLGGGYAGYGIYPDFADCYAFHMFYDNESARDDCEHYLKRFFDIHSMSVMPTRPMREITDPPIIWRYFVTPKAWRCQEEAMDEDAFTAAHVLHVNVNIPGAFIFSSGKNMGVFKGVGYPEDMGRFFRLEEYAATCWTAHGRYPTNTPGWWGGAHPFTLLDVSVVHNGEISSYDANRRCMEMYGYTCTLMTDTEVIAYMIDYLVRKQGLTYSEAANVLAAPFWSTIEHMPEDEKRRMLLLRQRFPSMLINGPFSILVGFTGGMMALNDRLKLRSMVVAETEDMAYVASEECAIRRIAPDVTNVWAPRGGQPVIFTTEGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG49</accession>
    <name>R7IG49_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MotA_ExbB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50283">
        <property type="protein sequence ID" value="CDE50283"/>
        <property type="gene ID" value="BN770_02346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="121"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="512" mass="55599" checksum="6F196282F84828E1" modified="2013-07-24" version="1">MFDEILQWFSSHLSNLTDALVYCAIAGVTLIGVFKCLIPLITTTHALRRAITRLQQDAGTRQGTPVWQEKRFMGNRLKNCWLRFLQNAEQLDRRGLPCNVEDYINDDTVIHGPGNAQLADLIPGLLTSLGILGTFMGMMDGLGGLDFSNADKIIEGIPTLLTGMQFAFGTSVAGVSCSICFNIINRILQGSSYRAIDDFVSNFTSLAMSRPLDNDVQLICQNQDSNHMLSTLTDTLPGQLAGAMEHSVRSAMQPVSQAMDNFLMGATRAQVDGVGRIVGSFVQQMNASLSDQLLTLGRTMTEVNQHQQASLEQVRQSLNAAAAIQVDMRQLHDVTNDVIAHFEQYIKELSAARSRDEGFERSSADLLTRLGKVSDQQLSALNRIRAGQEELARVTEQFTRQSSETTAAMKQSSNATTQELSGVADAMKQSAAELSAGCQNFTQSVVSGLSQSLGMFDASMQGLMAMMGETTDKLSGTDSAEATRQAAETQRLLTALKESIDAATAALRQKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGB9</accession>
    <name>R7IGB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Elongation factor G 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50829">
        <property type="protein sequence ID" value="CDE50829"/>
        <property type="gene ID" value="BN770_00223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="7"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="283" mass="31144" checksum="5E5F6BF4E0525C08" modified="2013-07-24" version="1">MADYITTNIRNIALIGHGSEGKTTLTEAMLYAAGLVDRQGRVEDGTTMTDFDPEETRRKCSISAATAPVDWNGKIINVVDVPGYFDFVGEMIGPLRVVETAVIVIDAVGGLSVGAEKAWDYAGAQGLGRMFIINQMDRDHADFDKISSQLRAKYGNCVVPILLPLGKGPTFRGVVNASAEATRGLSDRPLDPFGVHTTVYWLLLLQGISRLRARPKGNENRRSLRSPFGNLRITRAWKARRARTSAPSRTSPCRRERCTNGSIRPTRRRRAWFSGLPDAPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGE1</accession>
    <name>R7IGE1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000180">
        <property type="protein sequence ID" value="CDE50854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50854">
        <property type="protein sequence ID" value="CDE50854"/>
        <property type="gene ID" value="BN770_00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="672" mass="74952" checksum="92E60EE38BA62CAD" modified="2013-07-24" version="1">MINELSSLSKALEQAGIVPLQSYRNYIPLPNVSAKAPCIRIWVKGGQVVDFEAIDRALAMQLRKFGSNQASFPGLNLISLYRVTDESEKKLVAQCIEKPESIDALQLHALCKENAWEPHQNSRIKNCFSATPREMAGLLETAGNPKENLLNTLAAECAPFANAQVLHESLTKAVFAKLEKKQDVGLALLILFQLGDASKPCKDDKRNISVFFDTDAYDTYDMYAASREFTAYLNTAFLQAERIVTSNTTEDGLIDSFGQIYVPTNSPMPKVKLAAGFEPALYTMFDGQPCQNRYHNFDDKRDSYPLSAQHRVQFQASLNWLGGDAKNKGITWLNTGKGEAVFAYPSSLPEAPLPYVQFFGHPDRSETFKEISGSLLAAFNGIPPKDRPESVQVFVLRKIDKGRTKILYSESALADALMHAAENWDMACNDLPDIASIRLSAPFPIDVATVVNQVWRQDGESSTVSAMHPYEGIGLFLHRAQHRLLLHELHILVQHGMPLFIHAGPLLHSGRKCSRVAQLEQILPVLSMLLFFSGNRKDDYMEATPYLMGQLLKASDELHALYCKVVRNNQIPPQLVGSALFVAASETPGRTLSQLSVRMAPYLSWAKQYRTKNEDSSGLAGWYLKVFEQIANKLATEYSVPMRWSDAQKAQLFIGYLASFPKQEKQDESNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGW4</accession>
    <name>R7IGW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50835">
        <property type="protein sequence ID" value="CDE50835"/>
        <property type="gene ID" value="BN770_00226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="117" mass="12259" checksum="7F7ED2C75E2A8D44" modified="2013-07-24" version="1">MANYTKTNVGSTPRTELHDILGLTGAEVSINQLPAGAGVPFVHAHQQNEEIYGILAGKGKAVIDGEEIALTAGDWLKVAPAAKRQFSAAADSSITYVCIQVKENSLGGFTANDAIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGZ4</accession>
    <name>R7IGZ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative competence-damage inducible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cinA</name>
        <name evidence="3" type="ORF">BN770_00287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000190">
        <property type="protein sequence ID" value="CDE51079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51079">
        <property type="protein sequence ID" value="CDE51079"/>
        <property type="gene ID" value="BN770_00287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="412" mass="43527" checksum="A3844847E485BF3F" modified="2013-07-24" version="1">MIAEILCVGTELLMGQVLNTNAQFLSRRLSALGITQQHQTVVGDNAQRLEDAYRLALSRADIVITSGGLGPTVDDITKRVAAKVAGKELVLFPEAEEMVRTRFQQYHRNMTLNNLSQAMFTADSTLLMNPNGTAPGAIVPMGDGKVVIHLPGPPCELEPMFTASVEPYLMARSGRALVSRYVRIFGMGESEVDTRLRDLENGENPTLSPYCALGEMQLRATASADTAEKALALLTPLLAEVKARLGNVVYAIEETDGGSLAKTAIETLRAQGMTCATCESLTGGKVVAALVDIPGASAVVRAGLVTYQTDTKTILADVPAEVIERFGVVSVETACAMAEGTRKRLGVDIAVSTTGVAGPDGGTEDCPVGTVCVGVSTAGGTSAVRLALSGNRERIRTLAMKHALHMLIEKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHF2</accession>
    <name>R7IHF2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine desulfurase IscS</fullName>
            <ecNumber evidence="7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iscS</name>
        <name evidence="9" type="ORF">BN770_00236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000181">
        <property type="protein sequence ID" value="CDE50881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50881">
        <property type="protein sequence ID" value="CDE50881"/>
        <property type="gene ID" value="BN770_00236"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017772">
        <property type="entry name" value="Cys_deSase_NifS_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03402">
        <property type="entry name" value="FeS_nifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="4"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared with IscU</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="387" mass="41325" checksum="C0A2D10AAC6FA390" modified="2013-07-24" version="1">MDRIYLDNAATTAVSQPVMEAMLPYYMQVYGNPSSIHSTGRDAKKAVERARRQVAAALGCSAQEIYFTAGGSESDNWALKGAAFAHQEKGKHIITTQIEHHAILHTCQWLEAQGWQVTYLQVDADGFVTAQQVENALRPDTVLVSVMAANNEIGTLEPVAEIGALCHERGVLFHTDAVQAVGAIPLDVEALHADMLSLSAHKFHGPKGIGALYIRKSVKIDPLIHGGAQERGHRAGTENLPGIVGLGKAIELAEEGLAENAARMTFLRNRLISGLTAAIPNMRINGTMDKRLPNNVNVSFAGIEGEAVLLRLDLEGIAASSGSACTAGSLDPSHVLTAIGLTRDEAKGSLRLTLGTDTTQADIDEVVKKLPGIVESLREMTSWCGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7II77</accession>
    <name>R7II77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51028">
        <property type="protein sequence ID" value="CDE51028"/>
        <property type="gene ID" value="BN770_00268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="338" mass="36166" checksum="DFBED514E500822E" modified="2013-07-24" version="1">MEKAVTRRKWTAGLLIAGTVVLVVAFWSLIMSMLSLLAVAGVLTLLSLPLCKVLEKRLPSGAAAAIALLTLLGAVLGMLWGLIPPLLRQSALLMSRLPALLDSLRELLTRWSAALEARGIPLGDMQAELFSRISAAAGQLAATLVSGIRRLTGSVSQWLLAPLLSFYFLRDRKRLCLLLSLVLPVKYRARGIRAAREMRRESALYLRGQLILSLFVAAMTALALLLTRTPGALLLGLFMGVMELIPYIGPFIAGVPAVLLALQSGWTAALWTLLAICLVQQVEANLLSPRLLSGATRLHPLAVLLAIAFGGMAGGVVGMMAALPLVVCVRGAVRGWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IID8</accession>
    <name>R7IID8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein CUT1 family (TC 3.A.1.1.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50342">
        <property type="protein sequence ID" value="CDE50342"/>
        <property type="gene ID" value="BN770_00166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448303" evidence="1">
        <location>
            <begin position="26"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="598" mass="67829" checksum="E923B9C5326F8CC8" modified="2013-07-24" version="1">MRKLTRLFALMLALTMLLGALPALAEEPDNPSGIPYYKVTSDLYDFIDMDGAPIQIEIYSQLANYSGRQTGWGAALMKDLFNVELVIIPDQDGTYQTRTQSGNLGDIVVWGANGEDYKQAIKNGLLLEWDEDDLAETYAPYIWANYQDALASNRLVSEDDNNLYGFGMDVATSRQGHKSFMYSWDLRWDLYSQLGYPEIKNLDDLLEVFKKMKEICPTDELGNETYAASLWPDWDGNMVMYVKAMATAYYGYDELGFGLYNPTNGEFYDALDENGPYIEMLRFFNQLYRAGLLDPNSMTQTYDEMSQKVKNGGVFWGIFNYASSMVYNTDNHLGEGKMMYARVPDEANPIVYGLSTLGGNRIWSVGSKAAYPELCLAILDFFATPEGSMTMWYGPRGLMWDYDENGGMYFTELGDICNKDTKHDLNGVVWTSPYTGKQYTLSGNFNDGCIQANNTTYSKDAINPDGKLGETFNRDTWVSILNAVSYPIQEDWRNWSGAVLADPYFESIGKYTIMPDLPYSESVKDDELKVKWEQCAKSIKNNSWLAIYAKADGEFNMHIRNMITQCNNYGYADCLEWSKGEAATKWRLTQELNAVGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIH0</accession>
    <name>R7IIH0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000192">
        <property type="protein sequence ID" value="CDE51113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51113">
        <property type="protein sequence ID" value="CDE51113"/>
        <property type="gene ID" value="BN770_00289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="135" mass="14317" checksum="7500AC27143FED91" modified="2013-07-24" version="1">MSNSTKKGFGVYATLVSAVLAIAAAVIYQVIGGKFGATQRVCYDQWVVLLLIGGGVVSGALVGLKKYGVASAIAAFAPFAAICFFAHKCYWYVTDVFVAIDEKGFDPNFLWFAGLALGAFIIGEIAVYTRKEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7III2</accession>
    <name>R7III2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51440">
        <property type="protein sequence ID" value="CDE51440"/>
        <property type="gene ID" value="BN770_00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="265" mass="29862" checksum="719744E50DFEF3E6" modified="2013-07-24" version="1">MKTMHHGQMSESFLTAVFLSLSGGLQDAYTYLFRGKVFANAQTGNIVLLSAHIMDGQWGMVLHYFIPLCAFAFGVLVAERMRERFRSMQRLHWRQLVVLGEMLLLLIVGFLPESCNLLANAIVSFSCAMQVQAFRKVDGYAFASTMCIGDLRSGVEAFCIWSKTHESHAKDRMLRYFGIILLFALGAGIGSVSAGRIGAHAIWISCLLLLAAFALMFIREDLEQNPLIEKDISAIRKETAEIDRTLKQELKEEHRELKENATHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIJ7</accession>
    <name>R7IIJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000222">
        <property type="protein sequence ID" value="CDE51455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51455">
        <property type="protein sequence ID" value="CDE51455"/>
        <property type="gene ID" value="BN770_00452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="195" mass="20192" checksum="DB25D631969632D1" modified="2013-07-24" version="1">MKARGYQLIATGEMGIGNTTASTAMACALLCCSPEDITGRGAGLSDAGLQRKKAAIQRALSINRPNADDALDVLAKVGGFEIAGMVGIFLGGLRHHLPIVIDGVISAVAALTAVRIDPASKSAMLPSHMSHEPAVVRIMSELGMSPIIYADMALGEGTGAVSLIPLLDMALKVYHGPHTFDELGISAYEPQEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIT8</accession>
    <name>R7IIT8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000202">
        <property type="protein sequence ID" value="CDE51208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51208">
        <property type="protein sequence ID" value="CDE51208"/>
        <property type="gene ID" value="BN770_00038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="228" mass="25533" checksum="525086709AC567B5" modified="2013-07-24" version="1">MLELLALLMQQCLFFLGYITGRSEFPPALNRAEEAELIGKLDAGDHNARQELITHNLRLVSHIARKYQIPGYGADDLISIGVIGLIKAVDSFKSASGTPLGTYAARCIENEILMTLRASRKRRGDVSLSDPVGSDGEGNDITYQDILGTDADELENTVIRRVTAEKVQQVLHRLPARERFVLELRYGLTDGRQHPQHEIARRLGISRSYVSRVEKKAVALLRDEIERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIV5</accession>
    <name>R7IIV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Techoic acid ABC transporter efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51223">
        <property type="protein sequence ID" value="CDE51223"/>
        <property type="gene ID" value="BN770_00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="73" mass="8304" checksum="E4195606825527F2" modified="2013-07-24" version="1">MWAIDGLSPGLQRVMRLNPLVYIIEGYRKCLLYGEGFWSSPGQGAYFWLAALALLAAGCTLHMRLRNRFIDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIW1</accession>
    <name>R7IIW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000218">
        <property type="protein sequence ID" value="CDE51406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51406">
        <property type="protein sequence ID" value="CDE51406"/>
        <property type="gene ID" value="BN770_00418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="90" mass="10068" checksum="CCD636F2D5744E09" modified="2013-07-24" version="1">MLPLSTAAIATLVIFTFVGTWNDYMGPMIYLTRDENKTIQVGLRRFIQEYTSDYHLIMAASLVSLLPVSVVFLCLQKYFIEGIATSGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIX5</accession>
    <name>R7IIX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51426">
        <property type="protein sequence ID" value="CDE51426"/>
        <property type="gene ID" value="BN770_00431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="146" mass="16592" checksum="5ECD88A3446F7E0F" modified="2013-07-24" version="1">MGYLDGVTTILEVDGLKFKDLNGNGQLDVYEDWRQDVDARVKDLYEQMTLEERPGLFYHVNTCGNPMGVDFADSRYMFGTESVVPDESSSFTLRLMWYYINVLNITSHLGNTNDTPAQQIVYHNAMQALAEDSRLGIPVVISNDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ10</accession>
    <name>R7IJ10_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51630">
        <property type="protein sequence ID" value="CDE51630"/>
        <property type="gene ID" value="BN770_00533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="328" mass="37386" checksum="62FA756915E2A2F1" modified="2013-07-24" version="1">MENWSQSIQQTIDIIDRCIRQQEDEALTLRALSAALGYSESYVSRKFRALSGMSLRDYLRFRHLAFALRDVRDTSDSLLEIAVRYGFSSHEAFTRAFRAAYGVTPSAYRLHPTAVVLHTILKPFDCYLLGIGGTGMATSTDHIKTYFITIPAHKFLHIRNYESIGYFDFWQKQSLIPGQDWATICGLLERIPGSLDHFGGDERNASAGQLMAYINEPTGRICSWGIPLAEAYGIRLPADYAGDVPAPLQLMDVPEGEYIVFEHGPFDYETENTQVETEIERAMKDFDYAAHGVKLDTAQGRVFYFYHDCTRFWKYVRPVKRVEDILGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJA7</accession>
    <name>R7IJA7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">BN770_00495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51566">
        <property type="protein sequence ID" value="CDE51566"/>
        <property type="gene ID" value="BN770_00495"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="304"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="536" mass="59901" checksum="24F2F2B85E30BF34" modified="2013-07-24" version="1">MSTKFIFVTGGVVSSLGKGITAASLGRLLKCRGLRVSIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDESLTQAANVTSGRVYKTVIDRERQGGYLGATIQVIPHITDEIKRNILLVSKQENAPDVVITEIGGTVGDIESQPFLEAIRQMRAEVGFENSLYIHVTLIPFLKAAGELKTKPTQHSVKELGGIGISPDILVCRCEHEVPAEVRAKIGLFCNLPADRVFQNLNARSIYEVPLMLHKEGLDEKVCQLLGLTGLSCDLTEWETMVERQLNPIRETTIALVGKYVELPDAYLSIVEALTHGGIAHQAKVHIKWVQSADLTQENVAEALEGCHGILVPGGFGQRGLEGKMIAIQYAREHKIPFLGICLGMQMAVIEYARNVLNLRGASSTELDPNTLYPVIDLMADQNLDMLGHTMRLGKYRCALKHDTNSYKAYAQEEIWERHRHRYEFNNDYLTRFEEGGMTIAGKNPDRNLVEIVEIPDHPWYVAVQFHPELKSRPNRPHPLFRDFVGAAIKHQEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJG0</accession>
    <name>R7IJG0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">BN770_00524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51621">
        <property type="protein sequence ID" value="CDE51621"/>
        <property type="gene ID" value="BN770_00524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="193" mass="21598" checksum="43C3AFB417EC5F95" modified="2013-07-24" version="1">MEKETLIVVGLGNPGTQYAHTRHNAGFDTLEMLCRKWGVTLNKSKCKGLLTETTVDGKRVVLCAPQTFMNLSGECVSELLNWYKVPLENLLIIYDDIDLPASRLRVRKSGSAGTHNGMRSIIANTPGQNFPRVRVGVGAKPDGWDLADWVLSKYTIREEQIAMQQAFERAADCVEDWVKNGIDHAMQEYNKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJP9</accession>
    <name>R7IJP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted Zn-dependent hydrolases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51840">
        <property type="protein sequence ID" value="CDE51840"/>
        <property type="gene ID" value="BN770_00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="220" mass="23797" checksum="E2E739FD115F5D5D" modified="2013-07-24" version="1">MIISCMGHAKFVIELDNGLRVVTDPYDASCGYPVTANPADVVLVSHQHHDHNAVETIPGNPRVIDRAGDFDLGGGAAVRAIEAYHDEQQGKLRGKTLLFCLKAEGLTVMHLGDLGHMLTTEQRLLLGSADIVMLPVGGYYTMDAPMAKQVADVLHARVILPMHYKTAANASWPIAPVADFLRLYPEKAEELPLLRVSAGDLSCQPRLVVLMPLSLGNVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJW7</accession>
    <name>R7IJW7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">UvrABC system protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BN770_00239</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000182">
        <property type="protein sequence ID" value="CDE50892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50892">
        <property type="protein sequence ID" value="CDE50892"/>
        <property type="gene ID" value="BN770_00239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="436"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="476"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE50892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="778" mass="85227" checksum="4815F794B4865C54" modified="2013-07-24" version="1">MFGEARRSGFARVRVDGELYRLEEVPALDKKKKHSIEIVVDRLIVRPGKEFQSRLADSIETATKRSGGLVIMDMMDKGELLFSMNYACPDCGISIEELSPRMFSFNSPYGACPACSGLGYRMVVSTDILFPDKSLSLRQGGLNAMGFGSADGDGVTAQYFQALCDKYGFTMDTPIQEIPEAGIHALLYGTGSEKLTMTYDTPSGRGTYSTTFEGVIPSLERRYEETGSEAMKAAYEEYMAEEPCPVCHGKRLKPEALAVTVGGKNLYEVSSLSITDARAFFQSLALTEKESMIAAQILKEINARMGFLEDVGLGYLTLARAAGSLSGGEAQRIRLATQIGSALMGVLYILDEPSIGLHQRDNMKLINTLKKMRDLGNTLIVVEHDEDTMYAADWIVDVGPGAGIHGGNIVAEGTVEDIKRNPNSITGQYLSGKKRIEIPDVRRQPKGFLTIRGAKEHNLKNIDVKVPLGCLCCVTGVSGSGKSSLVNEILYKHLAKVLNRAKTRPGAFGSMEGVEQLDKIICIDQSPIGRTPRSNPATYTGLFDQIRKLFAASPEAKARGYKENRFSFNVKGGRCENCCGDGMLKIEMHFLPDIFVPCDVCKGKRYNRETLEVTYKGKNISDVLDMNIEEAITFFENHESIRRKLETLYDVGLGYMKLGQASTTLSGGEAQRVKLATELSRRATGKTLYVLDEPTTGLHMADVDKLIGVLQRLTETGNSVLVIEHNLDVIKVADYLIDLGPEGGDKGGEIVCEGTPEEVAACEKSYTGQFLKKMLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK03</accession>
    <name>R7IK03_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase family 65</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51955">
        <property type="protein sequence ID" value="CDE51955"/>
        <property type="gene ID" value="BN770_00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="6">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="319"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="5">
        <location>
            <begin position="694"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="353"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="587"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="754" mass="86070" checksum="1D58C888F4F81899" modified="2013-07-24" version="1">MSFPVHPWKVVERGWQPNTQRFAESLMSLANGYMGLRGNFEEDYSGDSFQGTYLGGVWYPDKTRVGWWKKGYPEYYAKVINAINLIGIHVIIDQHPLDLSRATVWEYEREVDMRTAVLYRHACVDMDKGSLTLDTWRFVSMDTKELLAIRYQVTPSFDCRMEVSPYLDGNVRNLDANYDQSFWNMVDGEGWDERGGVLVQTKPNPYGVQRFTVAAAMTNRVEGIDYIDMASKAGYCAALYAGDIHSGTTVSVEKYVAVFTSRDHDKDQLMDLAMAAAQQACDEGWQKALKAHQAAWHERWEMADVQIEGDDSAQQGIHFNLFQLLSTYTGSDARLNIGPKGYTGERFGGSTYWDTEAYCLPVFLAIRGADTARQLLLYRYHHLEAAKRNAANLGMPGALYPVSTINGSECHNEWEVAFEGIHRNAAIVHAIFEYTMYTGDETYLLGEGVEVMAEIAKFWVGRVHFNQRTQKYMIFGVTGPNEYENNVNNNWYTNRMAAWCLEYFVETCAKLDDDRLEALQITPDDLKHMQDIADRMYYPDDRGLGIFPQHDAFLDKDLRPASDIPAEERPIYMHWSWDRILRSGYIKQPDVLMGLYFLNHVYDTETLRRNFDFYAPLTLHESGLSPCIHSIMAAQLGEKDLAVAMYKRTARYDLDNINQDSQDGLHITSMSGSWLAIAKGFAGMRTLGGLRFKPFLPDCWNGYSYKFNYRGRIIELRVKPKGVTLTLISGEPISVTIYGHPYELEDVLTVPLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK30</accession>
    <name>R7IK30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51668">
        <property type="protein sequence ID" value="CDE51668"/>
        <property type="gene ID" value="BN770_00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032358">
        <property type="entry name" value="DUF4867"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16161">
        <property type="entry name" value="DUF4867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="210" mass="22877" checksum="00A1E33BA72045C5" modified="2013-07-24" version="1">MEILSVYDSAFKPYGRVVEGYPTEGLVKALATTPCTDGVVYLPRVEVLHSAPNAAKIGEGLYGGMPYELGYCNGHNTKLNCLEFHRDSEFNLGTDDFILLLATLSDLEDGELDTAKVKAFKVPAGVMVEVYATTLHYAPCHADAKKGFRVMVALPDQTNTDFRPEDGANKLDKTLWARNKWLLAHPDSSEAKQGAAVLLKGENIDIAGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK59</accession>
    <name>R7IK59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000186">
        <property type="protein sequence ID" value="CDE50992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50992">
        <property type="protein sequence ID" value="CDE50992"/>
        <property type="gene ID" value="BN770_00261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="382" mass="39125" checksum="ACF2FCF05BBE2C6C" modified="2013-07-24" version="1">MKMLFASDSFKGSLTAVEICDLLQEAAADIFPDAETVSLPIADGGEGTVDALLCAMGGERMTTRVTGPLFAPVDAQWGLLGDGQTAVLEMAQASGLPYVPAAQRDPRKTTSYGTGELIAEAVRCGAKSLLIGIGGSATNDGGLGMLSALGAVFTDRQGKPVPPTGGALADVCHADFSGLMPELADCRITVLCDVTNPLLGATGATYTYGPQKGATPEICAELEAGMKHYAQVVENTIGHGIADFPGAGAAGGLGAALGGVLKATLKSGIDAVLETVRFDEQLKQADLVVTGEGRIDGQSVQFGKVPIGVARRCAKANVPVLCICGGIGAGAEGLFDVCESTIQTTVSKPMALSEAIENARTLYLDAAKRLFRAVRIGQKLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKB0</accession>
    <name>R7IKB0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51911">
        <property type="protein sequence ID" value="CDE51911"/>
        <property type="gene ID" value="BN770_00691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="163" mass="18273" checksum="B7DD06076701D4E2" modified="2013-07-24" version="1">MKRKGMHRRRKLVLLAVLLIMVGIAVWRIWQTPRPVVLHRQDAWLSSAEPEMVDVLPDNTFTAELPEKIDGRLLYIRDYSASGHYQIVWEGVSAEAAEVYLNALLDKGFTRLMGTAEDIASGVLLARGDLTLSISLSGGTLNMLMTRAEESTPTPLPEWLADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKD7</accession>
    <name>R7IKD7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">M50 family membrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BN770_00712</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51946">
        <property type="protein sequence ID" value="CDE51946"/>
        <property type="gene ID" value="BN770_00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDE51946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="30449" checksum="8B285DEBA861FB99" modified="2013-07-24" version="1">MLSNLDTYLEALRTSPLEFLLTLVYAVAVILISLILHECAHGYVAYRCGDPTAKMMGRLSLNPKAHLDLIGTLSMFLIGVGWAKPVPVNPRNFRHGRRDDFLVSIAGIATNLCLCLICMFLSVVVGKIMFGSEMLGEVSSSALPHLFSPFYQFADGRDNVILSITNGIFAESALADFAVPWLRYVERFLLMMAQTNLGLALFNILPIPPLDGYHLVNDLLFKGKLQLKWQAFMIAQIVLILIFMTGALNQFLSKAIFAVYEFFLKGFLAIFGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKG8</accession>
    <name>R7IKG8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51788">
        <property type="protein sequence ID" value="CDE51788"/>
        <property type="gene ID" value="BN770_00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="327" mass="36817" checksum="54F7833BE5A1F627" modified="2013-07-24" version="1">MSENEKKKLLEIKDLKIYYPIKGKRDAEGKPAYVKAVDGVTFDVYENETFGLVGESGCGKSTTGRTVVRLNKPTAGSVTFEGHDLFAKMNRQQNMDLTQKIQIIYQDPYSSLDPRFTVGRCIEEPLIVHHMGNKAERRARVLQLMHDVGLREEVYTRYPHEFSGGQRQRIGVARALALDPKLVVCDEPVSALDVSIQAQILNLMRELQRKYQLTYIFISHNLSVVKHICDRIAVMYLGNIVEIAPKKELFDNPLHPYTKALLGAIPIPDPDIPAMQDMLEGDVPSPINPPKGCCFHTRCHGCCKECTAQKPKLINVGNDHWVACCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILL5</accession>
    <name>R7ILL5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="11" type="ORF">BN770_00472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51517">
        <property type="protein sequence ID" value="CDE51517"/>
        <property type="gene ID" value="BN770_00472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03280">
        <property type="entry name" value="ABC_MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="10">
        <location>
            <begin position="711"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="538"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="333"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="786" mass="87176" checksum="8F9AAB7FD3CFAB8C" modified="2013-07-24" version="1">MMKERTLRVLEFTKIRDRLASKAMTDMGRERCEALVPSSNMTEIQRMQAETEEATVILQYVGASPLVPFSDVRASLTLAEKGATLSPKALLEVAALMQSARAARKALDTERDNTPILKELAQRLSTLHNVEQDITNAIISEDEIADRASNELMDIRRHLRGANERIKEKLNQMIRSSAFQKYLQDPIVTMRNDRYCLPVKAEYRSSVPGLVHDQSSTGATLFIEPMAAVEMGNELKTWAAKEKQEIERILAALSAEIAPYADQLRETVETLAELDYIFAKGMLSREMNAVSPKLNQNGYINIIRGRHPLIDREKVVPSNLWMGKDFTSLIITGPNTGGKTVTLKTVGLLTLMAQAGLQVPADLGTELAVFEQVFADIGDEQSIEQSLSTFSGHMTTIVSIMHEVTPDDLVLFDELGAGTDPTEGAALAQAILQRLLNIRVRTLATTHYSELKAFALSTKGVENASVEFDVETLRPTYRLSIGVPGKSNAFEISRRLGLPENLIDDAKKLLSSDSVRFEDVIANAEYHRQVAEREREIARQASAETVKLRDEAEKLRKQMEDQRENTIKKAKADARRIMEQTRRESESIIADLKRMKKEQQNPDAQVNAIRRRIENNVDNLSEGLLQKVDTGLPPKEVRKGDTVEILTIGSQGTVLAPANAKGEVEVQAGILKLKVNISQLRLVKQPDKPKPQPTSVHLKTGAMERTVRMECDVRGMALDEAIMTVDQYLDQAILAGMGEVSIIHGKGTGVLRSGIQQHLKHHMHVASCRLGVYGEGESGVTIVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMD6</accession>
    <name>R7IMD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000243">
        <property type="protein sequence ID" value="CDE51757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51757">
        <property type="protein sequence ID" value="CDE51757"/>
        <property type="gene ID" value="BN770_00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448430" evidence="2">
        <location>
            <begin position="28"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="245"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="465" mass="51741" checksum="52D0C32C7A8633E1" modified="2013-07-24" version="1">MKKGKKRLLLGWICLLLSLCMVTAASAETDGTPIQSCHQVTMTEQKSTAQSGASISVWHITTALGTVDAELNALADDYAAELSPLLQKPGRERTQNSALTVRILHSRTGMSWMSFMVQARQEYHRQIQQVRFTTRTYDMLTGQRITLADIFPADSPAWELISQTVRDKANAYYPDETPEAAAVEALCENLAQADFMLYGMSLVIPLPSVYENHPQLMQATLYYPQIHAYMTEEAQRQTDNASLYRFCALTYDDGPNQWITPHVLDALMKTGARATFFLVGSRVSDFAYLARQEHDEGHAIATHFYEHLYANQEQSGKFRAMYDKVNRAHIAAIGIAPAYARAPGGQWQRMGSYGVGWPLIQWTAEAQDWSGGDQGAEPQDGSGGDQGPDAYRTANTIAASTKDGGIILMHDMKINSAKATEMFIPKLEERGFMLLTVDELFAKDGVTLEANQAYWRCLDGVTTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMP2</accession>
    <name>R7IMP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51897">
        <property type="protein sequence ID" value="CDE51897"/>
        <property type="gene ID" value="BN770_00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023975">
        <property type="entry name" value="Six-Cys_pep_SCIFF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13165">
        <property type="entry name" value="SCIFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03973">
        <property type="entry name" value="six_Cys_in_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="66" mass="7086" checksum="024C45685E623053" modified="2013-07-24" version="1">MKHIETIQKPCLKNSLAHGGCGECQASCQSACKTSCTVANQSCANKENSDVLAGNEGKLNRLYNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IN08</accession>
    <name>R7IN08_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">BN770_00748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CBJB010000255">
        <property type="protein sequence ID" value="CDE52017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52017">
        <property type="protein sequence ID" value="CDE52017"/>
        <property type="gene ID" value="BN770_00748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="60"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE52017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="298" mass="32811" checksum="CF799CEC8A5CE0B2" modified="2013-07-24" version="1">MNFPAFSFPHLPGRNDPCWCGSGRKYKSCHCAFDQQIASLAAQGHIVPTHKMIKTPEQIEKIKESCKINIAVLDEIGKQIHEGMTTAEIDDIVSTMTRDMGGIPAPLNYEGYPYSVCTSVNDQVCHGFPSKHVVLKSGDIINVDCSTILNGYFSDSSRMYCIGDVSDENRKLVQVTKECVELGLAQVKPWGFLGDVGQAVNDHARANGYRVVREIGGHGCGLEFHEDPWVSYVTKRGTEMALAPGMIFTIEPMVNMGTDEVGTHPGNTWEIFTADGKPSAQWEIMVLVTDTGHEVLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3A3</accession>
    <name>R7I3A3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">BN770_00845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46364">
        <property type="protein sequence ID" value="CDE46364"/>
        <property type="gene ID" value="BN770_00845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="485"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="548" mass="57697" checksum="6805477EF753BBA0" modified="2013-07-24" version="1">MAKQIQYGEQARRSLEKGVNALADTVKITLGPKGRNVVLDKKYGAPLITNDGVTIAKEIELEDPFENMGAQLVKEVSTKTNDVAGDGTTTATLLAQAIIREGLRNLAAGANPMVLKKGIAAATDAAVEGLKELSQPINGKQAIANVAANSAADETIGKLISDAMETVGADGVITVEESKTMTTGMTIVEGMQFDRGYASAYMVTDTEKMEAVLDDPLILITDKKISVIQEILPLLEQVVQMGKKLLIIAEDVEGEALSTLVVNKLRGTFTCVAVKAPGFGDRRKEMLQDIAILTGGTVISSETGMELKEATLDMLGHARQVKVNKENTTIVDGAGDKDQIAARVGQIKAQIAETTSDYDREKLQERLAKLAGGVAVIQVGAATEVEMKERKLRIEDALAATRAAAEEGIVPGGGIALLSVQQNVAALLPKYSGDAKTGVQIILRALEEPIRQIAANAGVDGSVIVENIKTTKKRNAKKAAGYGYDALNDEYCDMIERGIIDPTKVTRSALQNAASVAAMVLTTESLVADIPAPEPAAPAGGAGMGGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3S3</accession>
    <name>R7I3S3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46554">
        <property type="protein sequence ID" value="CDE46554"/>
        <property type="gene ID" value="BN770_00931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="119"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="397" mass="45421" checksum="2C80C88D21834D5A" modified="2013-07-24" version="1">MKNFVFISPNFPVNYWQFCRQLRNNGLRVLGIGDQPYDTLLPELKSALHEYYKVGSMENYDEVYRAVAFFISKYGRIDWLESNNEYWLERDAMLRTDFHITSGFQVSDMPRIKFKSKMKEYYQKAGIATARYHMVDNFDGCKAFISEVGYPVIVKPDNGVGASHTYKLSSDDDLRHFLIIKELEVSYIMEEFIHAEVNSYDAIINSKGEPIFETGNVSPVSIMDIVNNDDNSVYYIVKDLHDDVRKVGRATVKSFGVRSRFVHFEFFRLTEDQPSMGKKGDVVALEVNMRPCGGFSPDMMNFANSTDVYKIWADMIAYDSTLMPQGEHAFCAFAGRRDGKHFRLSHEQLMTKYAAQMKMVGRVPDALSGAMGNMMYVANFPTEDAMNAFYADACGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4C7</accession>
    <name>R7I4C7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46500">
        <property type="protein sequence ID" value="CDE46500"/>
        <property type="gene ID" value="BN770_00909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="260" mass="27949" checksum="620758BCB216525A" modified="2013-07-24" version="1">MNKTKQEKWQRAYGDTPDSFRQRVAASLPKGEESRHVAFPRRAMVLAAALVLVLTTAYAAVVTHTELVWNAGHPIENEADDHLGLLTGKAGTSGDSLTIGGVTFTVQDGVYSPENGQLFASAVISADESVQLVAVEADMEHEVRLTTPVDAKLDPSGISWAEWAEQNGKTLVPIGMEAAPTLQFLKVNGQTTDTPLIGAFLTQNPDGTVSLGIQVDLTEADMSHLKSCEVQLECRVGAFGKDGKATQWQKEILTATITFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Q4</accession>
    <name>R7I4Q4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46466">
        <property type="protein sequence ID" value="CDE46466"/>
        <property type="gene ID" value="BN770_00879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447494" evidence="1">
        <location>
            <begin position="27"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="96"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="243"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="304" mass="32629" checksum="8F60C6381F49FDFE" modified="2013-07-24" version="1">MNKKNLTCVAGLSAAAMLALSGMAMAETTESALVKGGALNLRETASLDAKVLGQYPTGTLVEIIKAGSEWHRVSVNGKTGYMLAKYLNSADSAISATVRTNTGTGLNLREQPNMNGTIIMAIKNGQSVSVLQKSSPWSRVKVGNREGYVATKYLNFGSSSGSVSGTAAVVHNPKSTQVLNLRREPNLDAQVLAYYHNGTKVTILGNVDSKWVKVQVQDGKIGYMMKQYLKVSGGAGEVKPFTAKLWNVNGGSYVNFRKGASLNAEVLARVPVGTEVKVLEHGTDWCKVEVDGKTGYISTWFMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I554</accession>
    <name>R7I554_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000021">
        <property type="protein sequence ID" value="CDE46626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46626">
        <property type="protein sequence ID" value="CDE46626"/>
        <property type="gene ID" value="BN770_00963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="44"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="276" mass="30469" checksum="72A0640487F6BB0A" modified="2013-07-24" version="1">MRKKHWWILPVLAILVILTLIALDERLILRTYTVVSPKLTAEVRLAVVTDFHSSDNADDVVAMVASCAPDAVLLVGDLFDDDTQNRPTERTLSLMRQLSAQYPCYYVSGNHEAWTGEMDALYRQTEEAGVTVLRMSSGILTVRGQRIALCGVPDPYEMVFSGAPDTEEQLRQALEDVDSADFTVLLAHRPELLAKYAQFPLDLVVSGHAHGGQVRIPGVLNGLYAPNQGWFPKLAGGAYTQDGTTLIVSRGLAVRTRLPRIFNRPEVVLVRCVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5D7</accession>
    <name>R7I5D7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PyrI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46840">
        <property type="protein sequence ID" value="CDE46840"/>
        <property type="gene ID" value="BN770_01048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="8">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="140" mass="16098" checksum="A2F090D1F8DACF03" modified="2013-07-24" version="1">MKIDAIHRGIVLDHIKAGRAMDIYRYLHLDELQCPVAIIKNARSEAMGLKDIIKIDDEIDIDLDVVGFVDPGTTVNIIKDGVVVEKKRLELPERLVNVIRCKNPRCITTVEPSLDQVFRLTDRARRIYRCIYCDAERKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5H0</accession>
    <name>R7I5H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46508">
        <property type="protein sequence ID" value="CDE46508"/>
        <property type="gene ID" value="BN770_00916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="232" mass="25407" checksum="E2C7C1A471025834" modified="2013-07-24" version="1">MGTLNVTSTSNGIMEQLRSALSDQFSAIAPFEIVLGLVLGLLVGLLIAFVYKRCFRGVLYSPSFAMTLAMLTLITTPVVMCISSNVALSMGMVGALSIVRFRTAVKDPMDTAYMFWALTMGILLGAKLYAIALVVAAAIAAIIFLLTFVHFTTPNSYLLVVHYDEEAEYDVDQMMRRSVKNRRLRSKTMTRSGAEMTWEVRLDNKQDLVALMLGIEGVHDATLVACQTEAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Z6</accession>
    <name>R7I5Z6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3666 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46673">
        <property type="protein sequence ID" value="CDE46673"/>
        <property type="gene ID" value="BN770_00985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022133">
        <property type="entry name" value="Ribose_5_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12408">
        <property type="entry name" value="DUF3666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3666" evidence="2">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="211" mass="23370" checksum="1E5E2DD594283960" modified="2013-07-24" version="1">MRIALINENSQAAKNAMIEGVLRKVVEPMGHEVVNYGMYTAEDECQLTYVKAGLLASLLLETGAADYVVTGCGTGEGAMLACNSFPGVLCGHVVDPSDGYMFAQINDGNCVALPFAKDFGWGAELKLEMIFQQLFGFGHGNGYPKERVVPEQRNKKILDGVKKVTYRPLLDILKDLDQDFVKETISGEHFAEYFYRDSKDEAIKAYLKELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I602</accession>
    <name>R7I602_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase superfamily exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46921">
        <property type="protein sequence ID" value="CDE46921"/>
        <property type="gene ID" value="BN770_01072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448012" evidence="1">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="41"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="282" mass="29830" checksum="34C7D5E7D5FE2E8A" modified="2013-07-24" version="1">MKRLLAALLALMMLLTMTSCAAPDAAETDDKLTLVAFNVGKADALLLTSGDTAYLIDTGTEDSWTDLSRALEALGVTHLTGVIVTHMDKDHYGGAKQLAESDIAIDGWYASWAWEKEKWKKHPVVKAAAVRGEEITLLQPGDTLSDGLLTVIGPIQEREESENDNSLVLVASGGGGKMLLTGDMEYDEENDLLAAGVIPSCEVLKVGHHGRDDATSAALVAAVQPKVAVISTSSVILPESPAKRVLRVLSSAGAQIVQTQQAEIGVRVTLSGGNVTVEFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I613</accession>
    <name>R7I613_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47274">
        <property type="protein sequence ID" value="CDE47274"/>
        <property type="gene ID" value="BN770_01195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="171" mass="18217" checksum="F1C8F062C2A441A5" modified="2013-07-24" version="1">MALKKDNLPVNVDVDTEQGSSITYANEVVAIIAGVAASEVEGIAGMCNVSGNLLGKNRAVTKGVKVEIGTEEASVDLYVVMEYGTPIQKAAYDAQESVRKAIETMTNLHVVRVDVHVQGVSFEKENNALNAGAKKALAEDKKETPLVEAPESEEKAAEDSTEVPEEEGKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I641</accession>
    <name>R7I641_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000042">
        <property type="protein sequence ID" value="CDE47309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47309">
        <property type="protein sequence ID" value="CDE47309"/>
        <property type="gene ID" value="BN770_01208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="133" mass="14308" checksum="782855DDF17C8608" modified="2013-07-24" version="1">MTRNAAYDAGQWPILPLPALPFIPELPADDAAPISQAALTALLDATSVAKTSDEEITAVLSPIFAMVSPLSGAARAEMYRFIRVAAALMEGGLPVALDFAILLWVVPMFDRTSRNFADFKALLDEYPLSQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6B3</accession>
    <name>R7I6B3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion-translocating oxidoreductase complex subunit A</fullName>
            <ecNumber evidence="8">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rnf electron transport complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnfA</name>
        <name evidence="9" type="ORF">BN770_01122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47031">
        <property type="protein sequence ID" value="CDE47031"/>
        <property type="gene ID" value="BN770_01122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00459">
        <property type="entry name" value="RsxA_RnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011293">
        <property type="entry name" value="Ion_transpt_RnfA/RsxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01943">
        <property type="entry name" value="rnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="196" mass="21171" checksum="D781A5E6FE3C63AB" modified="2013-07-24" version="1">MSNIWANLLTILVGGLLVNNFVMNRFLGCCPFLGVSKQYDTAKGMSMAVIFVMTLASFITWFVQHLILVPLHLEYMQTIAFILVIAVLVGIVEMALKKISPSLYQSLGVYLPLITTNCAVLGVAILNVDNGYNLLESTFNGFCAAAGFGLAMILFSCIRERLALANMPKWMNGFPGALITAGLMAIAFMGFGGLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6P4</accession>
    <name>R7I6P4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMN_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46928">
        <property type="protein sequence ID" value="CDE46928"/>
        <property type="gene ID" value="BN770_01077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435473" description="FMN_bind domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="233"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="309" mass="32638" checksum="27E0669DB2F7BFDA" modified="2013-07-24" version="1">MQTRREFLKKSAALLGSAAVVGSVPGLLKAQAEDGQEVPAYPYPYVELDPAYVEKLAYEGYFENGCCFGVAKAILVALREKVGYPYTVIPEEMFANGKEGYTCGTLCGALGGAVAMIGLVCASADSRQLTKDLFAWYCSTNLPIYQPEAAAPVQTVAPSVNCIDSITKFMTAANVERGDIIRKRRCGGLSGDVARRTVELLNAHFGFAELPVASPVAEEETLAPNEYIGEAQSFGGTLRVKVTMDGDKIAKIDILSHSDTAGVCNPAYDTVPGKIIDAQSTAVDAATNATISSKAIMAAVEDALSKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6P9</accession>
    <name>R7I6P9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane proteins related to metalloendopeptidases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46207">
        <property type="protein sequence ID" value="CDE46207"/>
        <property type="gene ID" value="BN770_00782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="117"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="225" mass="24258" checksum="0996A8EB01951678" modified="2013-07-24" version="1">MADRHFRSLFRALHLRREQWTFLLMALLCVSVIVGTALWTRQAEFARVTPTPPISGDISAAQLLQQSLDSAQTATPAPTVSPTVRSVTTPLESMTLLRPFDNTRMRQSSATGLWALHDAADYAGAEGAKVSAMADGTVINCADSGVFGAYAEIDHGGVLVRYANLSMLYAIRAGDPVRAGQTIGFIGRTMPEECDLPAHLHLRIVVGNTAVDPEKVLQNGIFPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7C4</accession>
    <name>R7I7C4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000053">
        <property type="protein sequence ID" value="CDE47540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47540">
        <property type="protein sequence ID" value="CDE47540"/>
        <property type="gene ID" value="BN770_01280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="215" mass="23825" checksum="37DD88C4A430A24A" modified="2013-07-24" version="1">MQKIIRHLFCQPHMARRIVVLILSVTIMGACVSVFDRIQFGTDPASVLNLGVANKLNMLLGTYQMLFYGALLIVVMAMRQWEFIGLGSIANMVLVGYSKDLFDVIFSSLNILNRDAMGMTERICWLVPTLGVFMVAVAFYMVVELGSGPYDAIPQIISKYVKKIPYAVIRMIYDLSAIAIGWLLGSTVGVVSIVTGFFLGPIIAAIAKKFRPWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7E7</accession>
    <name>R7I7E7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha amylase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46447">
        <property type="protein sequence ID" value="CDE46447"/>
        <property type="gene ID" value="BN770_00865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="13"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="557" mass="64321" checksum="809F7A104760881E" modified="2013-07-24" version="1">MKDAWWKEAVVYQVYPRSFMDANGDGIGDLQGVTSRLDYLQELGINVIWLSPVYQSPNVDNGYDISDYQAIQPEFGTMADFDELLKQAHRRGIRIVMDLVVNHSSDQHPWFVESRKSKDNPYRDYYIWREPKADGSAPNNWGSCFGGSAWQLDPETNMYYLHLFAPQQPDLNWKNPKLRDDVYRMMTWWCDKGVDGFRMDVISMISKPDEMPDDPNAPVGGYGNFGAYCIHGPHVHEYLKEMNARVLSRYDLMTVGETAGVTIEEAQKYAGEDSHELSMVFQFEHVDVAGKYGAWRTEQIPMLFLKKVLSKWQTELHGKAWNSLFLGNHDQPRTVSAFGDDRPQWRVRSAKMLATCLHMMEGTPYIYQGEELGMTNCPFQSLDEFRDIDSLNGYRRWVTDGPLTHDEFFPYLLFKSRDNARTPMQWDDSPNAGFTHGTPWIRVNPNYTEVNAAAAMADPDSTFYYFQKLIRLRKAHPVIVHGRYELLEKDDPALFIYTRTLDDAQLLVMCNFKEQRREWTMPAGFAGAQVLISNTGRTQQTEQTITLQPYEALVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Y1</accession>
    <name>R7I7Y1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000021">
        <property type="protein sequence ID" value="CDE46622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46622">
        <property type="protein sequence ID" value="CDE46622"/>
        <property type="gene ID" value="BN770_00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="327" mass="36861" checksum="5DCE2828AA649AEC" modified="2013-07-24" version="1">MTQRASNAEIAADLCGAQAQILRNALFTLQSRTGSSDFSGLLKTWTLRGTLHLIPESDLPLYVHQQGTAEDVCDTPWYGWMTKCGCALPPEREKAFARLMVQEIASGNDTREGLRQACQAAGMTANEEKMVFHGWGGVIGELSLLGVICAQVQEKKAYRLCAPFAPMDAAEAELTLARRYFTHYGPASLRDAAYFFRVPQTRVKAWLKQLDAREISVDGRMYYATKDAPEGEMPHVRLLSGFDPMLLGYRKEDNPILPPEHLRGVFNLTGIVHPTALADGQIVARWREKDGKVELMPFENIGARTKKRIEREVEKWFEVKEIRWMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Y5</accession>
    <name>R7I7Y5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47388">
        <property type="protein sequence ID" value="CDE47388"/>
        <property type="gene ID" value="BN770_01233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="294" mass="32156" checksum="360217718D24C24B" modified="2013-07-24" version="1">MKRKIVTLGETDITVHPAAGILLLFGLLTRWRALLICTYASILLHEMAHAAVSALWHHPPQEIEITPLGAMMRLEDEERLPLTARISVILAGPLMTLILCALSLRLTQNGVIPREAGRLIFLSNAGILLVNLLPALPLDGGRLLSAVLSRLLRRETCWRVMRIIGTAAGALLVVGGVVGAVRRWQGSWSLAAAGCFLLYSAVSATTSAALTELRALMDRKIRMETRGKLPIQPMAMLSTRTLHHAVRALHPTRMTQLYIIEPGTMRLLGILTEQQLIAAYLSAPQRTLAEEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I850</accession>
    <name>R7I850_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48054">
        <property type="protein sequence ID" value="CDE48054"/>
        <property type="gene ID" value="BN770_01513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="63"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="497" mass="55036" checksum="0DBFEF185327090B" modified="2013-07-24" version="1">MQWAERVRAYVRMHGAGYTLHRAGEMLAARVLLRDEWRFRREKASKRELAAQRAHPFPNVRISVVVPVFNTRPKFLRALADSLLAQTHGVWEVCLYDGGSTSAETRKALEAIAARDSRFHVAYGVENAGISGNTNRAIKMASGEYIALCDHDDVLAPDALWRIAEAIDAHHPDVLYTDEDKLTAHGAIHVDAHRKPDFCPDNLRSGNYICHLSVIRRTLLDAIGGLRPAFDGSQDHDLLLRACERADGVIHIPRVLYHWRTLRGSMSHTKLAVCLDAAARAVEESMRRTGFPGTCRVEDGVLRLRYDVGDFTVAALRLARDASAADVNRLAADASADMLLFLWGDTAAPDADGLREMMMYAQRPDVCAVMPLVADARNRVLHAGYDILPDGTVRSRNRGLPVSAGGWHGMNRTSYNVTAVSPMCFLVRRNAFVPLAEGESLAVDLAQWCMARMQEGMRHVYTPHCVVKADAESAFEGFRVKVPAGWYDPCATGSKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8A1</accession>
    <name>R7I8A1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000052">
        <property type="protein sequence ID" value="CDE47518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47518">
        <property type="protein sequence ID" value="CDE47518"/>
        <property type="gene ID" value="BN770_01274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="85" mass="9333" checksum="5B79B34F3D372F99" modified="2013-07-24" version="1">MTKQKAYVQFSKQIVLLVTIAVTAISLLAVVLCFFRSDTDALISTVRTYINYATIVFAAYSGNSVFEKWLTQGKSADAAGDTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8I4</accession>
    <name>R7I8I4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ORF">BN770_01433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47920">
        <property type="protein sequence ID" value="CDE47920"/>
        <property type="gene ID" value="BN770_01433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="392" mass="44223" checksum="3B17420BDFC1D39D" modified="2013-07-24" version="1">MSKKHDSYESIRDERRYGPYWYSALWRIIRPILIGLGAVLVVSGILFSVWNKVYGEFIAPPDENSTAQVPFTIESGQSLTRVANRLEEAGLIRNRTVFKYYCDFAGWGQKIQSGSYTLSPSMTMRQIADQLTRGDGNPIVRNITLIPGWTIEQFAEQLVKDGVLTDSTEFLSLCKSGTSFSEFYSVQDVLNSRNVSQRRYVLEGYLAPDTYEIYIGATASEIIRKLITQTERVFSVACEDRAEEMGYTMDEILTLASMIEKEASKADFTKVSAVFHNRLKAGMKLQSDVTIHYITGVRKMSLTNSDLALDSLYNTYQVTGLPLGPICAPSADAINAALYPDETFVAENYLYFCATSPESTELHFSRTLQEHEQAVAIYAPLWQQYDKERGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8T9</accession>
    <name>R7I8T9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48030">
        <property type="protein sequence ID" value="CDE48030"/>
        <property type="gene ID" value="BN770_01506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="329"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="392" mass="44945" checksum="6E87DC1CE385FE7D" modified="2013-07-24" version="1">MDYLSVKEIAELWGVSIRMVNYYLNTGRIQGAIRKSGGWLIPANTPHPADLRKSGQRGQEKIPPRMAKCYMPLISRPCDNGFQNLLLTMNDEEERDITRAMHHYFRDEHEEAREISEKYLTSKCPEIRLSALITNTMAMLQTGDAAKCRRNLEMIQRDGQRANDDSWRLYSSITDALISVFFHSEKLDLTPIRPAIGILPPGMQYFAMYAIAHALYIRREYEHAMGIAESALLMAGTRYPIDSIYLNIVLCMICMSLKQDERAEQKFDAAWSIASREGYIHPFVEHHGILQGQVERALRKQEPETYNKIVQSVYRFSRGWMKIHNPVSTLQVTDALTPYEFSIAMLAAKGRSNKEIAALMGISVNTVKSYMESIFEKLQISSRNEIDAYVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8W9</accession>
    <name>R7I8W9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein CUT1 family (TC 3.A.1.1.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000094">
        <property type="protein sequence ID" value="CDE48304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48304">
        <property type="protein sequence ID" value="CDE48304"/>
        <property type="gene ID" value="BN770_01632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435623" evidence="1">
        <location>
            <begin position="30"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="477" mass="51955" checksum="7E77721800B2E50B" modified="2013-07-24" version="1">MMKKNLKYLLALLCIIVLLLCTGCSSDSAAPQPISITVWTYYNGTLLESFNTLVKTFNETVGREKGIIVEAYSQGSVNELEASVMQSAEGKVGAAAMPNIFSAYADTAYALDKLGLVVDVSSYLTADERAAYVDNYLTEGDFGQTGSIKIFPVAKSTELLFLNETDWQPFAEATGTQESEMLTIEGLLAVAERYYNWTDAQTATPDDGKALFGRDAMANYLLIGAQELGCTIFEVDGDGRLTLHFDRDIIRKLWDSYYVPFIKGYFSAAGRFRSDDIKTGNLLCYVGSSSSGTFFPSRVITSDTESHDITLKVLPCPKFADGESFAVQQGAGMVVTAADEAKVRASVEFLKWFTLPENDISFSVGSGYMPVTKAANNMDTIKAAGLTLSPVVEQVLTGAVATINENRLYTPLAFEGGQAARKVLEYALSDKAAADRAIVVERIAAGMSAEEAEAEFLTDECFDSWYQETLTKLQAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I976</accession>
    <name>R7I976_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47072">
        <property type="protein sequence ID" value="CDE47072"/>
        <property type="gene ID" value="BN770_01128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="376" mass="43010" checksum="4F65400B84C5481B" modified="2013-07-24" version="1">MLNTMFPTINRESSMLGFGCMRFPTTPDGKIDESEAIRMIRHAIDNGVRYIDTAYPYHGGESEIVIGKALKDGYREKVILTTKLPVWLVKTHEDMMKFLDEQLKKLDTPYVDFYILHAMNNERMDAMQKLDYKRFYAEAIAHGKVRYPGFSFHDDAKAFLRILHDWDQWGMCQVQMNILDDENQATLEGIREAGRRGVGVVVMEPLRGGLLANPPVDVKAVYDAYAVQRSPVEWGFRYLYAMPEVITILSGMSTWEQVTDNLRIFDMAKRPTLTDEELALYQKVKATYLARTKTRCTGCKYCQPCPMGVQIPRIFQGYDAAMLRADSSFKAGYAQIQADHADASQCIHCRKCERVCPQHLPITRFLEEIHAASTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I979</accession>
    <name>R7I979_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47818">
        <property type="protein sequence ID" value="CDE47818"/>
        <property type="gene ID" value="BN770_01379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="84" mass="10370" checksum="244C32CE243CD7A9" modified="2013-07-24" version="1">MKCPRCRSRDVRVELVRERRATRHSLAWWLLIGWWIWPFKLLFLPVIWSQEAERKGKRPPPRRDEMVTRSVAVCQHCGHHWRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9H2</accession>
    <name>R7I9H2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48141">
        <property type="protein sequence ID" value="CDE48141"/>
        <property type="gene ID" value="BN770_01554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="435" mass="48980" checksum="19464A465BCC0465" modified="2013-07-24" version="1">MLKKDIQPRPAYLKWVYIGMMTIAFWNGGLGLPWFTKYVLQVGVLGMALLFMLVTGDFRRLKTVGQFAVMFGLPFVMMAALSMLYWALDFQQLNYMSRGCSTILYHVISLSAMCSAVYLFGRRSIDYTLYGMCGANCCIVLGSIKENGIGAFVTGLIAFAKSGGIDTNAAIKALEVHDLTFAFGLMLLFALCCERGKKRLLYAALSGLFFFLGLKRIALIGLLGVFLMGEFIRRRKPKVQSVLIIIISIGAIAICFGYVYLIQSGLFNEIVHALEIDTMGRDRLYAAFQEVYDFSPAFRGYGIGYVTRYISIMTEAGVGVFGTHSFGGMHNDIVTMYIELGFWGFAFWIWYSWNGRIVWCQKEFGMQTALLLLYETIYGFITYATDNTVFYCYINTAFMLLPIAMAIGEQEQGEEKGKHERKEPETSKERRVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9K3</accession>
    <name>R7I9K3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alfa-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48250">
        <property type="protein sequence ID" value="CDE48250"/>
        <property type="gene ID" value="BN770_01597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="3">
        <location>
            <begin position="133"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="2">
        <location>
            <begin position="301"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="516" mass="57260" checksum="FAA66BBBD73CD2F4" modified="2013-07-24" version="1">MQAIRLKTEHLFDPVGVDFVAPRLYWNCSGGRKQTAYQILAADDSGSTLWDNGKVESAAMCVKWSGAPVPPKTKVLWKVCLWDEDAAVGDWSEASFETGIGAWSAKWITGNYTVNKEERYPVDCFRKVFRAASIKKARLYMTACGLYEAAINGQRVGDFVRAPGITDYRKRIQYQTYNVTTLLQDGKNALTVQLADGWYRGSCGAWGLKNHYGTETKLLAQLELTHTDGSVQTVATDAGWDWSNDGPIRFADNKDGEVVYANNVPSYQGKAKVTNHPVTPAASNNVPVTEHERLKAKRITTPSGKTVLDFGQNIAGYAEFTVTAHIGQKIKLRFGELLDENGEFTQKNIQCSSKKITTPLQQVIYTCKEGKNHYKTTFAIFGFQYVLVETDVAFQSEDFAVIAVYSDMERTGFLKAPTHFSISLLKTPSGMPRTTTPTCPQIARPANATAGRATRRFSSTLRHIFLTMRLLHRNICGMCTTGRKKTGSCRKSPPTAVWISICPLWTEASAGRMRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9N1</accession>
    <name>R7I9N1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48003">
        <property type="protein sequence ID" value="CDE48003"/>
        <property type="gene ID" value="BN770_01485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="283"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="386" mass="43474" checksum="31F02F2F4FA62C84" modified="2013-07-24" version="1">MRAEGFTRGDAFLQLNFHPRKQVNPLMTQEQEQQLSQTMLAMMQSGGDAPKSTVEVPVYAWRLIRWEADVPLTEEQRQEALAIVPEAMALCGVSAACFAADGDVMTVLLALTRFPARAHRDPVLWLCAHALMEQASVALEQDGTMFIGEEFDLAATWAEHLKPMREISDWWTRVSPLDGAAAHRHRKELQTCIKRRQYAVLGGYVSRALREDQNLSVTCFAFVPLVIEAIWSQHAELSLRTLTEGLNLNEMTRRPRQALLAWLNALQPSLRACPQPGNAKPIEKVIDSIRADCSLPYSQANLSRSLGLTPAYFCRLFHEKTGQHFSTFLTRTRMEKAQMMLSSKEPQTLGEISAACGYPNKSYFCQVFKKYTGMTPGEYQAMAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9Q5</accession>
    <name>R7I9Q5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane-associated Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48320">
        <property type="protein sequence ID" value="CDE48320"/>
        <property type="gene ID" value="BN770_01645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435608" evidence="1">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="115" mass="12173" checksum="0F84110F61A4D3F9" modified="2013-07-24" version="1">MQRKHIISLCILLCVLAMVVAFRPSADETMPLTGSASAGLILLDGQSGGYYVLAVIDQSRADRAGIEAGDTLLTLNSQSPADLTALDAFFSAQQQPCVITIQRKGKTLDINLPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9R0</accession>
    <name>R7I9R0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">BN770_01650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48325">
        <property type="protein sequence ID" value="CDE48325"/>
        <property type="gene ID" value="BN770_01650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="216"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="226"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="245"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="448" mass="47800" checksum="7184E0F530AFCDF1" modified="2013-07-24" version="1">MSDTIAAIATAPGQGGIAIVRVSGDMAEDILRRIFRPVGGKHPLPTHLLTYGYIVEDTERIDECMAVIMRAPKSYTREDVVEFQLHGGGCVAQKVLALCLASGARLAQPGEFTRRAFLNGRIDLSQAEAVMDLIAAQGEQSRKAAMRQLTGGASSFIRKAADELYAIQAGVAACIDYPEEISEEEAASDLAPRIAHLAKTLTDACDERAARLLQSGLRVALCGQPNVGKSSLLNALLGEEKAIVTAIPGTTRDLVEGTLMLSGSVIHLTDTAGLHDTDDPVERIGVDRARRALADADVVLLVLDMSRPLSAEDESLLRTLHGRNGCIVLNKSDLPPVLTESNLQDAADDKPILTVSASVPDSLQPLKSYLASQAAVSDQLTLTQPRHIAAARRAVAALHQAEDTLRSYSVDLAGVDLQQAQMALAEITGDEVEEKLLDEVFGRFCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9R5</accession>
    <name>R7I9R5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48330">
        <property type="protein sequence ID" value="CDE48330"/>
        <property type="gene ID" value="BN770_01654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="73" mass="8103" checksum="3C338E38314FE8BF" modified="2013-07-24" version="1">MSESLLVALISGFCTLAGSCAGVLASSRLTQYRLAQLEKRVAQHNNLIERTYRLEGRMDEAEHGLQEIRGRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9S4</accession>
    <name>R7I9S4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F420-0:Gamma-glutamyl ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48644">
        <property type="protein sequence ID" value="CDE48644"/>
        <property type="gene ID" value="BN770_01765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="247" mass="27401" checksum="48FF411DDF459841" modified="2013-07-24" version="1">MASESRNLAQQRREKDGIVYFERGILTGRDGRRYQRYAIQTHFVEVGESAAELVKKYVLPLAQPGDVLSITAKVMAMCTGNVRRMEDMKLGFFAKHMAKFAGINSTGVGMHEPYKLQLVIDMVGLPRVLLAGFVSAVTRPFGVKGLFYKICGHGVAGIDGFYFRSSFDRYKTLALINPEHPVELSNEIEKECGIPIVIMDANDIDQNQLGKCDDFPLTDDQIQDAMKDNPSGQGGELTPLILIRPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9Y2</accession>
    <name>R7I9Y2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48108">
        <property type="protein sequence ID" value="CDE48108"/>
        <property type="gene ID" value="BN770_00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435615" evidence="1">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="255" mass="27399" checksum="5BF349A18CE36A14" modified="2013-07-24" version="1">MSKTLRRAALLVLMTMLVCAVAWASGDIDWDTPAAGQNLSGNAAVETLKDYIRRVNETLVSSGAGKIDPCYELYPTFASLGLNGAEFAQHAEITVNMNATGITSLVLRMDNLTNFALIGGALVQQTSPNSITLDEAVSAVQAYVRKVQESNGNGVVESFEEQPILSQGTQTRLYGAYYPNQYHDNANWMQLTIIFPQPGSVDGGLLLNNDAGPTATPDPDGDEISGYFPFDGFQDSHLEVFVTPTPEPDSAAMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA18</accession>
    <name>R7IA18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000095">
        <property type="protein sequence ID" value="CDE48311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48311">
        <property type="protein sequence ID" value="CDE48311"/>
        <property type="gene ID" value="BN770_01638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="52" mass="5342" checksum="FF4F0C0EC0BCDEF7" modified="2013-07-24" version="1">MNLISSAAGRRVVRLGVLILGAAMLIYGAQRGEAATVLSKAVRICLECVGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA46</accession>
    <name>R7IA46_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000099">
        <property type="protein sequence ID" value="CDE48351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48351">
        <property type="protein sequence ID" value="CDE48351"/>
        <property type="gene ID" value="BN770_01669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="1">
        <location>
            <begin position="40"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="115" mass="12841" checksum="F4B9829600851F6E" modified="2013-07-24" version="1">MTLKEFYAAVGGDYDATLNRIPKESMVLRFVKKYADDKTYAQLTEAVKAQDWETAFRASHTLKGVAQNLGFDGLYRAAFALTEEMRGGKPLTDTALYDAVTQQQQIVIDAVRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA60</accession>
    <name>R7IA60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KWG repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48749">
        <property type="protein sequence ID" value="CDE48749"/>
        <property type="gene ID" value="BN770_01807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436313" evidence="1">
        <location>
            <begin position="21"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="451" mass="50437" checksum="2CD277ACB75101BE" modified="2013-07-24" version="1">MKKLLCGILCLLLLLGCASAEGYWYAAKGDNGLWGHIDEMGNWVIPPKFDSAGDFRGNYAWIQQGDREGFANRDGEIMLLLDENVVTDSGYDGFCYGGRETGIWLLYKKATGKNSLGTEWMEGFFDVQSGVFSGLKWRGVNHRESNSRLIAVADETGKWGYVSRDTGEMVIPAKYDSDNMGSNFYDGYAVVTFLDDDYNIVQTLLLDETGKEYPLPEGINAANCDTVISGGLFEVVDENGLYGYCNTSGEVVIEPQFAYTFEFADGYAEVELTDGTYGVIDQTGKVVMRTTDTHYADVRHGCYVLPTGEHSFTMYSVAGEELFTLQGENIVRLWTPEENGLCMYVVEKGRQRRCGWVNMQGEIISEAKWTFPEYDQPDVYFPSGLQAVYDIDGTRLAGYLDESGELAIPLQFSFVTQFYGELAYVGMAQDDGTTRCGYINQQGEWVYSWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA99</accession>
    <name>R7IA99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48799">
        <property type="protein sequence ID" value="CDE48799"/>
        <property type="gene ID" value="BN770_01818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="35207" checksum="D21F5C912D4FB272" modified="2013-07-24" version="1">MYWSVTADGEPLDKTKHTYCQAFAIYGLAAYMRAIGESDPDYAPARDKAMALFRLIETKCSDAGGYGEAYEPDFTPVGNEKLSDNPKLMERHETASRTMNTLLHVLEGYAELYRAMPDEAVRRAGEVCLERFLNVMYNPGKRRLEVFYDRNYRSLLDMQSFGHDIEASWLIWDAAETLLPESNRAPYLHMCLTLAEAVRERAFTDHGLENEVVEGKVDHTRVWWVQAETVLGFLNAYELTGASTWLRQAEAQFAYICRAFVDPRPNSEWFWSLTESGVPTDKPIVEEWKCPYHNSRMCLRVMEHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAC9</accession>
    <name>R7IAC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48839">
        <property type="protein sequence ID" value="CDE48839"/>
        <property type="gene ID" value="BN770_01839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="108" mass="12023" checksum="66AF223FBBC54960" modified="2013-07-24" version="1">MQYCALEKEGFLGTFYERETPSEKAVILVGGSGEGRAVKVLQPYARKIGMSGLSLGAAYTLLCADGKSPEVTQRLLAKMMTMEAKYPEECNRARADSWTKLVDFFQTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAM6</accession>
    <name>R7IAM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48635">
        <property type="protein sequence ID" value="CDE48635"/>
        <property type="gene ID" value="BN770_01758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="325"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="475" mass="52464" checksum="85EB52EC0221A355" modified="2013-07-24" version="1">MNTRKNTLYNVAYRVFSMLLPLVTAPYLSRVVGTEGVGLYGYSWAVSYVFVLIGLLGLENYGPREIARVRDDRDALNRTFSAIWKMQRLVAGVTLLVWLVYVFFIAGEEKIISLNLTMMSVSCLVNLDWCLMGLDEFKPIALRNTAVKLLAAAAVFLFVRKPEDLWVYAFVWSLSTLLGCLSCMFSLHGKVTPVKVTWKEALKHLAPCALLSISVIAVSVYRQMDKVMIGALADMAQTGLYENAEKIILCLSGFISAIGTVMLPKVSRMTRMKQMDAVQRHIRLSMELVMCMVCAMAFGLAAVAVNFAPLFYGDDFAYSGTLMMPLAFTLLSIGFANVIRTQWVLPQGRDTIFVHSVLTGAVINLIANFVLIPPFGAMGAAAATVLAEFSVPAVQFVYLRKELPYAHYLKTTGVYCLFGLVMAGVVALLGHVLPLHGWGKLAVQVTGGAAVYGALCLTYWTLAKRSDIFRLMRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAQ1</accession>
    <name>R7IAQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48655">
        <property type="protein sequence ID" value="CDE48655"/>
        <property type="gene ID" value="BN770_01773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="189"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="33914" checksum="0217F85A27B50564" modified="2013-07-24" version="1">MKRLTRFQENISVRKATNYAIIINSLEILLILGVMALVVISPQYDFSPRMVRLLVGVAAAVIIWGAVMDIREAMSTRRLLSQLDAMDDTIDAMEKLNNTLRAQRHDFLNHLQVVYSLMEMEEYGEANSYIEKVYGRITAVSRVLKTASAPINALLQVKLAACEKAGVQVTLNITSTWKELPISGWEMCKVLSNLIDNAIDAMADLPNGKKHLTITLTENLKEYVFSVANTGTPIPPDDQQRIFEPGVTTKSDGHGMGLFIVRETLRHYGGDIQVTSDAQETVFSGTVPKDTTIPEAKAAQENSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB56</accession>
    <name>R7IB56_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 type 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000112">
        <property type="protein sequence ID" value="CDE48543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48543">
        <property type="protein sequence ID" value="CDE48543"/>
        <property type="gene ID" value="BN770_00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448126" evidence="1">
        <location>
            <begin position="25"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="181"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="358" mass="39147" checksum="C842D404A4E78623" modified="2013-07-24" version="1">MRTRILPLLITMLFALSLASNAAANENSKMTPGTIAVVNNPDSNDRLNLRTNPSPDAPTLGKYYNGTYLEVLSNEKNGWVKVSIFDLEGYMMAKFLVYPEQLEVGSSTVPSVKINNIGGTGLNLRKAQSTDSSSLGLYSNESTVRVFGVSETWCHVQTEDGNVGFMLREQLSPVLEYQKSSNSAVVNNPNSIGRLNLRTKPSQEAPSLGKYYSGTSVEVLSGDENGWTKVRFHTLEGYMMTKYLVFGQEQFKVGYAMPSVKINNTKGVGLNLRQDQSTNSPSLGLYKNGSVVCVFGVSQTWCHVRTEDGNVGFMLRENLSPLLEYNRVSAPTGDELEGSWFGVPGDPITDDFMPGGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBA3</accession>
    <name>R7IBA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000122">
        <property type="protein sequence ID" value="CDE48860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48860">
        <property type="protein sequence ID" value="CDE48860"/>
        <property type="gene ID" value="BN770_01844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="209" mass="25499" checksum="F0663E2983BB1B02" modified="2013-07-24" version="1">MLDILAIKADVYQLERQGKRLPVYRYLREVWQKEPPSEGLTVLALQQMVDYVDDLTVLGEPWEAENEYDLYQDFLLDVISWGLQKYRAKKRFLWQICYYVNAWATFYYIFGREITQDNVEQWKKTLFEEAKERYPDSMMFEFIPHAAQLDYVWFYRLTDEQRLQIRLEVGEWNLQKNNMDQAVQSYFDDAMTWYRDNGRKLLEAKKQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBA4</accession>
    <name>R7IBA4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48746">
        <property type="protein sequence ID" value="CDE48746"/>
        <property type="gene ID" value="BN770_01804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="161" mass="18095" checksum="D1A03A435EAB3C37" modified="2013-07-24" version="1">MIRRATEADLPEMRRVFDAARAYMAAQGNPNQWEPGYPTDEVLRGDMARGGLHVLADDTGIYGAFAFLTGDDPTYAEIDGAWLSDRPYATIHRVASDGTHRGVFAEVMAFAVAMQPHLRIDTHAQNLPMQRQIERFGFRYCGVIQCRNGARMAFERVSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBG8</accession>
    <name>R7IBG8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49229">
        <property type="protein sequence ID" value="CDE49229"/>
        <property type="gene ID" value="BN770_01948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0680">Restriction system</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="229" mass="26111" checksum="90C7619D7306FF57" modified="2013-07-24" version="1">MLPEKVDMIFADPPYFLSNDGISCSAGKVVSVNKGDWDRIGNVEEKHAFNRQWIKLCKRVLKPNGTIWISGTLHNIYSVGLALEQEGYKIINNITWQKNNPPPNLACRCFTHSTETVLWAQKNDKGARHYFNYELMKQLNDGKQMKDVWSGGLTPAAEKHFGRHPTQKPVYLLERIILASTKENDVVLDPFCGSSTTGVACKRLKRNYIGIDAEEQYIKLSIERLRNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBQ8</accession>
    <name>R7IBQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47942">
        <property type="protein sequence ID" value="CDE47942"/>
        <property type="gene ID" value="BN770_01442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="229" mass="24847" checksum="B54F88AD3C29D009" modified="2013-07-24" version="1">MIRTVIHINEELCSGCGLCASACKEGAIAMVNGKARLIRDDYCDGLGNCLPACPVGAISFVQREAAAFDEEAVKEHLARKQQVSGCPGMKVRTMKRAAANESAENADNGSRLRQWPVQIRLAPLTAAFYQGADLLIAADCTAYAYGRFHQDFIRDRIVLIGCPKLDDTDYSLKLTDILAKNEIRSVTVVRMEVPCCGGISYAAEKAVARCGKKLPMQIITIGTDGEICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBV3</accession>
    <name>R7IBV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48753">
        <property type="protein sequence ID" value="CDE48753"/>
        <property type="gene ID" value="BN770_01809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="256" mass="28467" checksum="0754CB590E059205" modified="2013-07-24" version="1">MKAESKRSVRTVLRWLLGVATVLMAALLIWQCVTIYHEGIAPENMGENGLRIHDIYSREIVTAHFASIAWSVWVFLALLAANIIAGKPEQKESLRAPTENQLLMLRARTEETDEIRKVKKQRIGVWCGAAILCLICGGMAGRILLDWSNFASRDLEVVVRQMAIETFPWIGLAFILLMAAEQWNFRLLMKELELRRSAQKRKPDAAAPEKTTGRNVIRVIIAAAAVVLIALGVMNGGMFDVLVKAINICTECIGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICE1</accession>
    <name>R7ICE1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000138">
        <property type="protein sequence ID" value="CDE49171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49171">
        <property type="protein sequence ID" value="CDE49171"/>
        <property type="gene ID" value="BN770_01929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="345"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="378"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="589" mass="64140" checksum="24F4D06F61C967A4" modified="2013-07-24" version="1">MKANKLKQQKGTLLRVLQYVKPYRVLVIVSLLCACVSAAAQLLIPILTGKAIDQMIGAGQVNLPGVLVFAVWIAVVAALSAVAQQFLATSNNKIAYNISRDLRNAAFHKLQRLPLSYLDAHPSGDLVSRMIADVDTFSDGLLMGFTQLFTGVVLIVGTLTIMLIKNWMIALLVVVLTPLSMFVASFIARKTHHYFTEQARVRGQQTALINELIEGQKVVQSFGHEAASLSDFDCINDELGRVSLNATFFSSLTNPSTRLVNNIIYAAVALVGALSAVGGGISVGDLSVFLSYASQYAKPFNEISGVVTELQNALACAARVFSLLDEDDRVPDKENAAVLSPKGTVDLKDVCFRYVPDRPLIEDFNLHVKPGQRIAIVGPTGCGKTTMINLLMRFYDVNSGAILVDGTDIRNATRHSLRKSFGMVLQDTWLKAGTIRDNIAYGRPDASEEDVIAAAKAAHAHSFIRRLPDGYDTVITENGGNISQGQKQLLCIARVMLGGENGELPPMLILDEATSSIDTRTEIKIQSAFARLMNGRTSFIVAHRLSTIQEADVILVMKDGHIIEQGTHEELLKKQGFYANLYQSQFALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICN7</accession>
    <name>R7ICN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49236">
        <property type="protein sequence ID" value="CDE49236"/>
        <property type="gene ID" value="BN770_01951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435764" evidence="2">
        <location>
            <begin position="19"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="503" mass="56482" checksum="0DEB0BFCB6256635" modified="2013-07-24" version="1">MLLFTLLLALLMAVPALAADFTYDDFSATLTVPDSYTMVTTSNLADHEDLLAKQGLTVEAAQADWAARGVRFQAWDAAGDMCIELSAVQDDFAMQYWDVNEITSDERATYRLGHSSDKNGYYRNLGYDYSSAQWKNGKNYARFLVLEYTRTHNGVSYAGYGRKSIRNGYSIYLECQVYGRSPKKADNNALQAILDTLKFNEIFPRPSSAVQRVTFDEVPPTETNSGKFTVSGTGTSGQYVILCLMRLSGGEPINYETQIPKNGKFSFTIQLPQEGVWLMTYTITDAGKEVLQEDKFSLTTYKKTLLIVNLDADLPEAIVGDTLTISGTTMRQTQVQCIIDGRYQKTITTNNSGKFSFKIDTSAEGTYDIVLTFQKKGYTTRRITSTATRALTEADKQEDIRAQADKPAYSTLTRLLDGYEGRYMVYTLFIDRVDQVGDEWYTFAAMRKTNSGGLRDEVVVRTTTQPTWQPADQVRMYLQCTGGYEIQGDATTKLPCFDYLFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDE5</accession>
    <name>R7IDE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49318">
        <property type="protein sequence ID" value="CDE49318"/>
        <property type="gene ID" value="BN770_01968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="206" mass="22038" checksum="02325D908B9A44AB" modified="2013-07-24" version="1">MANVLLLNGSPHAHGAIDLALTEVAQTLQECGLTTEIVHVGQQDIRGCIACGRCGVLHRCVFDDAVNALAPKFEAADALIVGSPVYYASANGTLTNLLDRLFYSTPFDKTMKVGAAVVSCRRGGASATFDQLNKYFTISGMPVASSQYWNSIHGNNAQEAAQDAEGLQVMRTLGRNVAFLVKSIAFGKEAMGLPEKEKRVGTNFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDN2</accession>
    <name>R7IDN2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queA</name>
        <name evidence="6" type="ORF">BN770_00155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000146">
        <property type="protein sequence ID" value="CDE49551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49551">
        <property type="protein sequence ID" value="CDE49551"/>
        <property type="gene ID" value="BN770_00155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="342" mass="38299" checksum="345267DAC23BFC79" modified="2013-07-24" version="1">MKTSDFDYELPEELIAQTPVEPRDHSRLMVVHRATGEREDKHFYDIIDYLNPNDALVINETKVIPARLLGEKEDTGVPVEVLLLRRKNQTDWEALVRPGRRLKPGTTCVFGGGLLKCEILESVPEIGGRIVRFHYEGVFEELLDRLGEMPLPPYIHEKLADQSRYQTVYAKNEGSAAAPTAGLHFTPELLERIRAKGVTIVPVTLHVGLGTFRPVQVEDVDKHVMHSEWYQVTEEAANTLNAIRAGGGRLICVGTTSVRTIETVATEDGIVHPGAGDTAIFIYPGKKIKAVDALITNFHLPQSTLLMLVSTFMGRETALDVYREAVQKKYRFFSFGDAMFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDP5</accession>
    <name>R7IDP5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0122 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49438">
        <property type="protein sequence ID" value="CDE49438"/>
        <property type="gene ID" value="BN770_02018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007394">
        <property type="entry name" value="UPF0122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04297">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="187" mass="21727" checksum="F48D3A5816207E55" modified="2013-07-24" version="1">MSESEITDVYNKMLEDLVRLCRILLNYQMIHGVDAEDIVQRVVLRALEKKEQLANHKNLYGWFVNACKLECITLARRSRIERRRLGISLPLEPEILIEKQQDELIQWLRKSEMNELLEELQARLTPLEKSVYHQYYEEDNSAADTADTLGIKRNTVNDAARRIRKKAAGLLFVTLLLCVQGGTFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDZ2</accession>
    <name>R7IDZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49656">
        <property type="protein sequence ID" value="CDE49656"/>
        <property type="gene ID" value="BN770_02079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="421"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="503" mass="55608" checksum="74A3076AD18AB0C0" modified="2013-07-24" version="1">MKRSVLDYLENTAKRCPERLAWDASAPFTFGQWWDAAQRIASSLSSRCARNTPVAVLMNPRSAECVKVFFGVWAAGCFYAPLDSMLPPERLKLIMQNLQPTAIVYDEESRAKAEAVCPDGCECVLWSDAAQSPVDADKLVQIRQTVTPDHLAAILYTSGSTGIPKGVAHTQGSLMAYTEETIERYQFTENTVFGNQSPFFYANSIIDIFPPALLGAKACMIPATALSFPKTLVNYLRQKGITELTMTPSSFVQVANSGVLTENCLPELEYMIMSGEVMPWAQLAVWMNAAPKGHAWNFYGSTEMFSVSVGKVEGNYEAGQLIPVGKPFPTVKIRFMTDDGQAAAPGEAGEMYVSSPMVSQAYYRDEERSRAVYVADPLGQEPGVWFRSGDYGFLDAQGQLNVLGRKDSMVKHHGYRMELGEVEAALRSIPGCLEACCLLDKEQDTLWAFAAGNLTEKALMDALKTKLARYMLPDKIVLLPELPHTANMKIDRQTLRKRMTEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE42</accession>
    <name>R7IE42_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein LpqB GerMN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50094">
        <property type="protein sequence ID" value="CDE50094"/>
        <property type="gene ID" value="BN770_02271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Germane" evidence="1">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="1">
        <location>
            <begin position="248"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="363" mass="38668" checksum="7480BFBA63924B58" modified="2013-07-24" version="1">MKLPKLPKLPSLKSLHLPSRITMERLLIVSAAALVVVLAVRGGQQTQTAMQQTDFTPDVSTQTIADASPDVEVTATVCWYEDGEGYLVPVTRQIPLQDGVAKATLSLMVKSSENDLAAARMGLRNVIPEGVTFDLDISGGKARVDLSKEALSCQNAEEELLMVQGTAAALCGFDTVQEVTFLFDGQKRSQLTHGTDVSGVFKADGVNLESVETTANLTNASRVQLYFPSADGRLMVPVTRTVFSPADLTTAMLELAKGPEKDSGLEIPLPKDCGLRSVTLKNGVATIDFTKEFASLATAEDASAATSQALRAIVFTASQFPGVKKVEVLVEGKPFEAQPSAVTTFVNQADEVMAQYPGLITVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE55</accession>
    <name>R7IE55_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49706">
        <property type="protein sequence ID" value="CDE49706"/>
        <property type="gene ID" value="BN770_02092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="391"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="502" mass="56498" checksum="94E59AA6C13B7E5B" modified="2013-07-24" version="1">MYTILIVDDERPAQTFIKAICQKYCPAFDTILLSGSADDALQLMAQQHVHVLVTDISMPGINGIELAQRVRQLYPRTHTVIVSGYAEFEFARGAIQAGVDDYLLKPVEIQSFRQILDRIRETLDAEANNLMEETLTRLLCGEAVDEPLLCSLFSSRMMRFALVRQGNLFTVRFAKFRTAQLRQVHQAGWIAFYGRDEQETILLRSSADRQKRFPDELSDLLKADFPDLPCTAIYAPEDADILTLPQFLSRAAGRMVNTVVIGKGQLVPLNAPQSALQPSVLSAATKKRIASFVETGNTRMLKELFVSLAIEWNQNSLPQIQAEDLCYQLILYTADLGVPGPKRKREQILREANELYGSASSYGDLLASLYSLIFEEGFIRDKNVSANELCEYTLNYIRENYAQPLSIPRICTDVGISQTYLSRLLRKYAGTTFNTFLTQCRMDAAKQMLREHPDILLHEVAACVGYDDQSYFSKIFRNETGMTPSQYAATFAADAPTQPPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE56</accession>
    <name>R7IE56_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000121">
        <property type="protein sequence ID" value="CDE48852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48852">
        <property type="protein sequence ID" value="CDE48852"/>
        <property type="gene ID" value="BN770_01841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="609" mass="69187" checksum="42BDD46613D3FECC" modified="2013-07-24" version="1">MTNEAEAAIQALQGASENAEEALWRAVVACQGLTFRTATGLPFTYCLKIGQNGQPNRELLIDRREKSKTLSWSSVCLAFRRAREIGYADRPKALGDIRGVSYVYPLLWRFGVLRVPEIVEKNMSLALDFGFFRDLKEAETMNQLMRTTPEEMGLHSQNILNLLERLEKENISVVSMMLLRHNQVLYEAYWPPYTQEQLRTVYSLSKTFTAMAIGIAAGEGKIRLDERIVDLFPEQVKNAPDSPQLQMLTIRHLLMMSTGQGSEPFHQENAWDDAISAFLREPFVDTPGETFRYNTGATYMLSAALKQRGIDLEEYLRDKLLTPMGITGTRWIRDPNGICTGGFGFSLHPEDIAKLGILLMQSGRWNGQPLVPEWYVREATTRQISSGDDSNSDWAQGYGYQIWQCRHGAFRADGMYGQFCVVHPATDTILVTNCITQNMGGVLNAYFDEVLMKYKSDAVVDEPEVTERLRQKTANLRYERDLPEDDGSDIPPEYLNLDAPNVWMRLTLDGDMLTMRNTQGQLLVIAGRGRWHTIHRAVHCEPFFTRDKTDTPALGAWGMKDGRLTLKIFEPEMVEEDTLTVEKTERGIHVQMRITTTGNENVFFDQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEH0</accession>
    <name>R7IEH0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000164">
        <property type="protein sequence ID" value="CDE50209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50209">
        <property type="protein sequence ID" value="CDE50209"/>
        <property type="gene ID" value="BN770_02319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="5">
        <location>
            <begin position="872"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="910" mass="101690" checksum="2357CFDC19E89FA7" modified="2013-07-24" version="1">MDKTWARFRDRDELTFCLIQAKKQLTFDRNGKPIKTADQQYTYVTKNWTEGGEEPVWEFNNLPKYYFTVNENGEAQKKPYYYYIVEGYETINGALNPYLYQVSYTGDATLVKKTTGAVNQPADGGTANIHAKNLPGYEVGNLNLNLTKEWVNVNEKPEKVTLNLTETTHSWDKTEGWITDAPNSDTVEIMPDANGNWTTTYPLEAYSVEYNPDGSIHTAYVYTYELTEDPVSGTLPSYTFSANWPKEVGDVLELNSAGEPIKAKDAFKASSSQMEGSFLVTIADASATITNVQTGKLNIVKQWAEEVEYDGAQNPLDIKQVSISLLRNVWGENWTDSDGVVHYNWCHDPFQQNYVLSAENGWKLTIDNLPLYDTPLNPDGSLRKYRYYIFENTSVGNGTLDRYTPVMTADESELVGSILYITFKDTTENNVTITNVPKSISIVKQWADADTFGEEGMMQDIYLEVMMKYQEVYSTQWKTENLLEKSYFSLKNVICTPSSLTAELVQINGAPYLHVSGLAKADEPWRVTIRNLPGYNSASFIIREVELAGYLNNLPDGKLELGFNEIGTITNTPTKLKITKQFKQAYFPVGSESELPLNVRNTVVYLQIWREKRDGAGLSQHERYTPLLGALEANMDATILPDGTVKLTVGTNTPTDAATLTLTRLPRYWFDKDTGASGEWYYYVKEVDAEGNEVHSASSPTNGERPEINLNVKTLTVTNTLTDVSARKVWTSLDNQFTLNPANLPDITLTLKQTTAEAAADGDKIIATVTLGWDAEAGKVVAKNLDGWQFGEVVEYTAPEGSKNIWWGYKWYNLPAYDAGGNIYRYYAKEQTPVGSGWQLVTDDTNATNTAPIPANSENRVFQITNTPITYTLPETGGIGTLPYTAGGLLLMAAAALLLGQEIKRRREGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEH7</accession>
    <name>R7IEH7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_02239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50035">
        <property type="protein sequence ID" value="CDE50035"/>
        <property type="gene ID" value="BN770_02239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="128"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="230" mass="26671" checksum="AD35C254035927BF" modified="2013-07-24" version="1">MGKRILLVDDEPLILKGLKYTLEQDGYETDTAVDGQEALDKFFSGVYDLVLLDVMLPKVDGLSVCQRIRETSSVPIIMLTAKGEDMDKILGLEYGADDYMTKPFNILEVRARIRTVLRRAGGHVVQEQKIIRVHDMEVNLVKRTVTLGGEEVRLTAKEFDLLQMFITNRGRPFSRKEMLEAVWKYDDYTGDARTVDVHIRRLREKIERNPDEPEFIFTKWKVGYYFTDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEI9</accession>
    <name>R7IEI9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chain length determinant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50050">
        <property type="protein sequence ID" value="CDE50050"/>
        <property type="gene ID" value="BN770_02251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="249" mass="28026" checksum="26BD0F8894928A37" modified="2013-07-24" version="1">MASEHQAISQHQVEQEETTIDLAELFYRLLDKAKFIIVAALLGAIIAFCVTKFFMTPMYQASAKLYVLNSSGTSLNLSQIQLSSSLASDYVQVFDNWHVHEMVKRRLNLDYTYAQMGKMISVENPTNTRILKVTVQSDDPQEAADMALTYVQVAREFIAAKMDMDMPTIFEEPQLPTRPYSPSTMKNTVLGFLLGLLLMCGIVVVQFLADDRVRNADKLEKQLGLATIGMMPVQSYDLSREHKNGKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEK4</accession>
    <name>R7IEK4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-oxalocrotonate tautomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000153">
        <property type="protein sequence ID" value="CDE49861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49861">
        <property type="protein sequence ID" value="CDE49861"/>
        <property type="gene ID" value="BN770_02170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="PTHR11954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12794" checksum="911D2D2F5B39025E" modified="2013-07-24" version="1">MPYIETTSNVSIPGRKEQVIKDRMGDAIEKIPGKTESWLMLSFRDNAAMYFKGTDAPCAICQVKLFGGSATEEDYAALTEALTDILREELDIDSDRIYVTYEEIGFWGWNGGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEV6</accession>
    <name>R7IEV6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50150">
        <property type="protein sequence ID" value="CDE50150"/>
        <property type="gene ID" value="BN770_02299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435797" evidence="2">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="157" mass="17476" checksum="213EDF2FC6D63001" modified="2013-07-24" version="1">MSISSYLALIIIVIIVNVVKSAQKKKEAEEARRMPTAKAQQPKQSAPKVHSQPTVPMPAPMPAHAHTTVHAAQPKVHEHLAAECDLDAELQGSIGYDSPEGRDKCHEDELFPAHKKRPETPHEEVKPGLKLDFSPNAMVQAMVMQEVLTRPCERRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF73</accession>
    <name>R7IF73_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_02402</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50459">
        <property type="protein sequence ID" value="CDE50459"/>
        <property type="gene ID" value="BN770_02402"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="209"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="398"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE50459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="570" mass="62325" checksum="DE1990E438ABA607" modified="2013-07-24" version="1">MQCTGAKILMECLVEQGVDTIFGYPGGTILNVYDELYNYEGDGRIKHILTAHEQGACHAADGYARSTGRVGVCFATSGPGCTNLVTGIATAYMDSSPIVCITCNVGTSLLGKDSFQEVDITGITMPITKCNYLVRSVDELADVVREAFAIARSGRPGPVLIDIPKNVTAEKADYEPLPRSAHGTSGRLGKLMKRSSQNFKAPEPDHRDIDKLVEMIAASKKPLLICGGGVVRARAHHEFEALANRIDSPVAITVMGAGGFRGRNPLTTGMIGMHGSQASNMAVDACDLLIAVGCRFSDRVALKPATFAQNAKIVQIDIDRSEINKNVQTDHHIIGDARRVLELLLERVPSMKHDDWKQYVFSFKTETEYDEADDHLTPSQVLFSLAKLTPQDTIVSTDVGQHQMWAIQHFHFDYPGQLLTSGGFGTMGFGLGAAIGAQVSHPDKVVLHITGDGGFRMNCNELATEQYYNLPIINIVFNNGTLGMVRQWQTLIYDKHYEATTLDRAPDFVKLAEAYGLSGRRVRNQQELEEAIQEALQCGHGYIIDCMIDIDEKVRPMVGGGSHITEFMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFG3</accession>
    <name>R7IFG3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="8" type="ORF">BN770_02436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50549">
        <property type="protein sequence ID" value="CDE50549"/>
        <property type="gene ID" value="BN770_02436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435823" description="50S ribosomal protein L30" evidence="6">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L30" evidence="7">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="59" mass="6346" checksum="8D806CED825C889C" modified="2013-07-24" version="1">MLKVTLIKSPIASLPVHKATVAALGLRKVGQTVLKPDNAAVRGQIFAVKHMVKVEEVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFJ7</accession>
    <name>R7IFJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49337">
        <property type="protein sequence ID" value="CDE49337"/>
        <property type="gene ID" value="BN770_01984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="52" mass="5878" checksum="BC48B86CCF6DC96D" modified="2013-07-24" version="1">MKGEVVFRCMQSGDLSHLYAADEPYSTAALFPECYTGRDSTDPPEWDTLGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFT3</accession>
    <name>R7IFT3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49437">
        <property type="protein sequence ID" value="CDE49437"/>
        <property type="gene ID" value="BN770_02017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32631" checksum="BCCD0D323EE8FBD3" modified="2013-07-24" version="1">MSDPKEKEVQAILQAIDYGHLPPRETQRRLLNIIQAEAARTDAPTDETKIHTCMDLLERLQGEQKPIAPARVDALRQHIAAAHQKNERKRQKRKKIIAAAACSAAAIVVAFAVSHPLLWYENWTTSDEQQHFVTSHEIAIEMLETAVADPTLPSGDTVEVQSIAALDALIGRKTGIPEMVNGQWELQHRYVNFTRSGISISLMYVNAADAQQTIVGVINLISNPQYMMLSFEQSYEGTLQQFDGLNFYITENINKPVALWQGDDKLLLFSGRTSQEEVTSLLRTIIREIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG35</accession>
    <name>R7IG35_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50426">
        <property type="protein sequence ID" value="CDE50426"/>
        <property type="gene ID" value="BN770_02382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010380">
        <property type="entry name" value="DUF975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06161">
        <property type="entry name" value="DUF975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="286" mass="32182" checksum="ED0D320CB18379D2" modified="2013-07-24" version="1">MRTAKEYRRIAWNAIRPHWRVMLLISLAAVLPQLIEFFLQLLFGLIPPIDMQFWFSDPSRFLAAYDAFVVQTLAPNLLLNVLFNCLSVPLTLGLIGAAQRLLRGEDVQARHSLTYVPYSLRAIGLEIRIVLYAFWPLLALAAVTLVLLLIFHSHGVYQLFRLASLAAIAFGVTRLYSMAAAKYLMAKKPTLRVSDLMETSRTIMEDRRLNLFLLELSFAGWWLPMILVCAAVLLLVGYNAYVVCVLLLPVFVRAYMVTARAAFVDDWVGNLVSSADDTASITPKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG97</accession>
    <name>R7IG97_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50338">
        <property type="protein sequence ID" value="CDE50338"/>
        <property type="gene ID" value="BN770_00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="284" mass="31153" checksum="24765919DE946CAD" modified="2013-07-24" version="1">MADNCKLCRIALENVSVVRGGQTLLQDVSMHIHCGQLTVLIGQNGAGKTTLIRALLGEYAHGGTIRHVDGEGRDVAHMRTGYVPQHLEFDKEMPVTVEDFLAASLTRRPVWTGVGKKTRAQVMEALKMVEGEKLLHRPLGRCSGGELQRVLLALALHPAPDLLVLDEPVSGVDQNGLQMFLDTVVRLKEHHHMAILLVSHDLNVVRQYADHVVLLDKTVLKQGKPDDVFASPEFQKVFGLGAKTLNAQRLHGAERWMGRKAETPEEEIARAAAVVDDETKGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGA7</accession>
    <name>R7IGA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50814">
        <property type="protein sequence ID" value="CDE50814"/>
        <property type="gene ID" value="BN770_00213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="353" mass="39515" checksum="305F1FB8B8D9514D" modified="2013-07-24" version="1">MIAGAGIPSAVTYDSLVPVGTLIDREGNSISRDDLEPNMLRSYTYENQLVGMPFSCSAIMLYYNCDMFREVGLDPNTPPTTIAEMADDISKLMVKDGDNVTRYGLNVAVRRYQLANWIGGQGDYNFFGDNEGGRTAPMTKVTFGEDGTLRNFLTEWQKVIATGGYKPYEDDINEEFSLELFGMAIMSTARIGKIKSLVGDKFEWNVAALPKVNADDKGGIAVGGSCVVMFDPDNDPAQVDATWEFVQFMVSAEEQFQFHQATGYIPVNKTVYDLPEANKWFEENPMYKVAIDCIHASNPNVQEPFDIINWEIDSVIKTHMLAFANGEETLDECHDRIVEECNERLDDYHLAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGE6</accession>
    <name>R7IGE6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ORF">BN770_02075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49652">
        <property type="protein sequence ID" value="CDE49652"/>
        <property type="gene ID" value="BN770_02075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="120" mass="13894" checksum="7359A45083E4C267" modified="2013-07-24" version="1">MQNLQLVQEAAQELYKNKAGQIVALDVQGMTVICDYMLIAAGRTVNQVKALADDVDERMAELGVPIRRREGQNEGRWIILDYGFMLVHIFHTEEYEYYNLERLWTDGSNRLVLPFDQTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGG0</accession>
    <name>R7IGG0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ORF">BN770_02438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50551">
        <property type="protein sequence ID" value="CDE50551"/>
        <property type="gene ID" value="BN770_02438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="122" mass="13459" checksum="F4BF4097E492D2E5" modified="2013-07-24" version="1">MFTKRDRNEIREIRHARVRKKISGTPDMPRLSVYRSLKHIQVQLIDDVAGKTLCAASTLEKDVQAQLNDLDKKGAAKLVGKLIGERALAAGYKTVVFDRGGYVYTGRVAEVAAGAREAGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGK7</accession>
    <name>R7IGK7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ORF">BN770_02404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50463">
        <property type="protein sequence ID" value="CDE50463"/>
        <property type="gene ID" value="BN770_02404"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="183"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE50463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="339" mass="36980" checksum="20839A052A67BD36" modified="2013-07-24" version="1">MAKMYYEKDCDLNKLTGKTVAVIGYGSQGHAHALNLRDSGVDVIVGLRKGGKSWPVAVKDGFDVMTVPEAAQKADIIMILINDERQAEMYKQDIAPYLTEGKAIAFAHGFNIRYKQIVPPAGVDVFMAAPKGPGHTVRSTYVVGKGVPCLVAVEQDASGHCLDTALAYIAGIGGARAGIMETTMHDETETDLFGEQAVLCGGIVELMRCGFETLVEAGYEPENAYFECIHEMKLIVDLINKGGVAAMNYSISDTAEYGEYVSGPRILPYEQTKANMKAVLNDIQDGTFAGKWIAENKNGRCFFNSHRDALAKHPMEVIGKQLREQMLWKNDSNLDNASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHU3</accession>
    <name>R7IHU3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sbcD</name>
        <name evidence="12" type="ORF">BN770_00386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SbcD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000214">
        <property type="protein sequence ID" value="CDE51344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51344">
        <property type="protein sequence ID" value="CDE51344"/>
        <property type="gene ID" value="BN770_00386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="10">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="11">
        <location>
            <begin position="279"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="384" mass="43034" checksum="44AB26DF78F0E615" modified="2013-07-24" version="1">MRFFHLSDLHLGIKLYEHDLLKDQKAILDEIVALTRQYQPDAVVFAGDIYDRSVPPVEAVALFDDFMTQLRAALPNGEIMLISGNHDSAQRLDVFRSELSDRGIHMIGNPPMQKGETIERVTLTDDFGAVNFYLLPFVRPGMVRLVAGTKENGDNLSYPEAFSRLLALSPLNPNERNVLVSHQFFLPDGGDAENIERAENEVKQVGNLDAIPASLIADFDYAALGHIHKPMKVGSETLRYCGTPMPYSLSEENQQKGILMVEMGAKGDVQTTVLPLHPVHQVRKLRATREALLSGASEDFVSICVTDAEAVEMVGLRELLRERYPNLLELRREREETVELAALQERTETLSPYELCLQFAGERLNAEEKSLLTEVMNAMKEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7II94</accession>
    <name>R7II94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000213">
        <property type="protein sequence ID" value="CDE51330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51330">
        <property type="protein sequence ID" value="CDE51330"/>
        <property type="gene ID" value="BN770_00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37432" checksum="D62D7ABD02F3185F" modified="2013-07-24" version="1">MQFCLQLAPHANIRYRDAQVKLGQAELTCLLCALSLPAETQVTTIGGVPCLTFSANALTPEALALLGTHSTRLMLFECVDGGLLRPLDWGRTAYLPDDLSEILKYKGKTSAAFTHMMMNCARAASDFALAEQPLTVLDPMCGKCTTGFVALQNGMNAVCLDIDRKDLKEAADYFSNYLQFHRLKHRLAQSSRTLQKTAVPIAEYTFSDTKEHFAADDVRTLMLAEGDSGLVGDLLKKRPADLLVCDLPYGVQHAPQNGKKAESFPKLLERILPAWRRALKPGGSAAISFNTLTLRKDTLLTLLQNAGFMPLTEPPYDDFSHFVEQAVHRDFIVARNEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIA9</accession>
    <name>R7IIA9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000226">
        <property type="protein sequence ID" value="CDE51529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51529">
        <property type="protein sequence ID" value="CDE51529"/>
        <property type="gene ID" value="BN770_00478"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="52"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="393"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="663"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="738" mass="83798" checksum="246D9238585B5A41" modified="2013-07-24" version="1">MTYTVYEAMPLSQMLARVQKYYPGDGYKLVEKAYLFAQEAHKDQYRKSGEPYFTHPCFVASILVELSLDPPTIAAGLLHDTVEDCEGITLDTIRQEFGEEVAMLVDGVTKLNKLDFADKEEAQAESLRKMILAMGKDIRVVLIKLADRLHNMRTLKFQKEERRVAIARETLDIYAPIAHRLGVYAIKQELEDLSLRYIDPVGYENLVQKVGQKRSEREENIRMVIDELSAKLDEQHIHHTIDGRPKHFYSIYRKMVLQNKPFDQIYDLIAIRVLVDSVPDCYAVLGIVHTLWNQMPGRFKDYISVPKANMYQSLHTTVVGGRKMPFPFEVQIRTWEMHRIAEYGIAAHWRYKEGGGAANDLDSKLYWVRQILDWQSDTRDSREFLDTLKTDLFSEEVFLFTPKGDVISMPKGATPLDFAYRIHSAVGNKCVGSKINGRIMPLDTPLETGDRVEIITSASSKGPSADWVRICKTPQAQAKIRAFLKKEYREENIETGRAMVERECRRRGLNPPDVIKPEYYDSILKKYGFTALNDIYSAVGYGGMASVYVVSRMVDEQRTQTAQAAPKAEELLALTEENQPQRKASGKANHGIILPGNEDMDIPVRFGKCCSPVPGDDIVGFITRGRGVTIHKADCVNVLRGEAERRVQVAWADGDTGTGFCVSIKIVAYDHTNLLIELATIIGDANVPIKTVNTELDEKNRIATFRFVLEVKSREQMDKLVKLLQRKTDVIDVFRVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIE0</accession>
    <name>R7IIE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000230">
        <property type="protein sequence ID" value="CDE51559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51559">
        <property type="protein sequence ID" value="CDE51559"/>
        <property type="gene ID" value="BN770_00494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8247" checksum="1D4BFE3B79F62E6B" modified="2013-07-24" version="1">MLTAENARLHIQPLLGQDAADAHLDVNEPIRVILDRGVIEVFANGGTFWAALEAEGDLLTKTVSIAGAEGLKVYPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIG3</accession>
    <name>R7IIG3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50377">
        <property type="protein sequence ID" value="CDE50377"/>
        <property type="gene ID" value="BN770_00189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="221" mass="25250" checksum="34F49CC1342F9081" modified="2013-07-24" version="1">MKKEIEFTAKQVGERVKERRTELNLTMPELGKRIGVNKSTIQRYEADGVDPKRTMIINGLADALLTTPEWLTGLSEEKEYDARTLCQKDIEEHIKKYLDTVSSTVSGEPHQQLLTTFLGKMIDLYSVLCHYFANAMAEVDRVAEDEGLKQSIMRYAIEVGAIEERVYRKEMEIPIEDMKRFLDGILHIYDEGRTKVSMGDLFGIVTEAENRLAEKENSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIJ4</accession>
    <name>R7IIJ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">BN770_02377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50412">
        <property type="protein sequence ID" value="CDE50412"/>
        <property type="gene ID" value="BN770_02377"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="415" mass="44470" checksum="B1521AF8D6178BF9" modified="2013-07-24" version="1">MATYRIRPCARLSGEITVHSAKNAVLPLMCGALLTRETVIIEQIPALTDVKTLTDILRDCGVLMHADQAEKLLTMTADSPRSPRREDLLSRMRASVLVMGPLLARTGYARVALPGGCAIGQRPIDLHLKGMEALGAHVEQTPGFVTLRGKLRGGNVYLDFPSVGATENILMAAALARGTTRIENAAKEPEIADLCDFLTQMGAHISGGGTSTILIEGRETLHGCRYRPIPDRIEAGTLLCAAAMTEGSVLLRGVRPEHMRAVLYKLGESGVTLRESAAGLRLSGRATQPLQVRTLAYPGFPTDMQAPMMALALSLRGTSVFLETIFENRFMHAREMVRMGASIRIEDRIALVSGGHPLGGTSVTSTDLRGGAALMLCGLLAEGETTLHDPNGQIARGYEDLPGMLRALGAEVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIL3</accession>
    <name>R7IIL3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000223">
        <property type="protein sequence ID" value="CDE51470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51470">
        <property type="protein sequence ID" value="CDE51470"/>
        <property type="gene ID" value="BN770_00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="48" mass="5558" checksum="D4F51F2ECE122D37" modified="2013-07-24" version="1">MDEHGESGLTDYQLRFLLRELLAYAEQAPDKDAIVKHLEELLRDGEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIM4</accession>
    <name>R7IIM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51301">
        <property type="protein sequence ID" value="CDE51301"/>
        <property type="gene ID" value="BN770_00368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448315" evidence="3">
        <location>
            <begin position="24"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="4">
        <location>
            <begin position="29"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="370" mass="39308" checksum="3A5231FECD8D154C" modified="2013-07-24" version="1">MKKLVSLILALAMVLCVVSFASADETYRVAMITDSGDITDQSFNQTTYEACKAFCEANGVDFNYFKPTGDSDAERIAQVEAAIDEGYNVIVMPGYLFAAAIGECQPTYPDVKFIALDVSEYDLTSNGVDLSNASNLFSAVYQEELSGYMAGYAAVKMGYKKLGFLGGMEVPAVQRFGYGFVQGANDAAVELGIAADVSCEYVYGGKFMGDADITAYMDNWYATKGVEVVFACGGGIYTSAAEAAAKVGGKMIGVDSDQSPIINQYADGMTVTSAMKGLAATVKTLLTDTVAGNFDLHAGKVENLGLVSGDDLTLNYVGLPVETTEWNDTFTVDDYTALVKAMVDGKVTVSSDITVRPETTIAVNYNGNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIV2</accession>
    <name>R7IIV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51699">
        <property type="protein sequence ID" value="CDE51699"/>
        <property type="gene ID" value="BN770_00574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="36" mass="3790" checksum="2AE19D5735E6D628" modified="2013-07-24" version="1">MVWSIVALEAVSFTALLTLGAIWAVADMGLIVSLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIV3</accession>
    <name>R7IIV3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51396">
        <property type="protein sequence ID" value="CDE51396"/>
        <property type="gene ID" value="BN770_00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="343" mass="36714" checksum="F17645ABFE3379DB" modified="2013-07-24" version="1">MAVKVAINGFGRIGRLAFRQMFGAEGYEVVAINDLTSPAMLAHLLKYDTAQGSYCGKIGENLHTVEATEDSIIVDGKEIKIYAEKNAADAPWGKLGVDVVLECTGFYCSKEKSMAHIAAGAKKVVISAPAGNDLKTIVYNVNNDTLTAEDQIISAASCTTNCLAPMAKALNDKYPIVSGIMTTVHAYTGDQMILDGPHRKGDLRRARAGAQNIVPNSTGAAKAIGLVIPELNKKLIGSAQRVPVCTGSTTILVAVVKGSDVTVDSVNAAMKAQSSESFGYNTEPIVSSDVIGMRYGSLFDATQTMVAKIDDDTYQVQVVSWYDNENSYTSQMVRTIKYFAELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIY8</accession>
    <name>R7IIY8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000232">
        <property type="protein sequence ID" value="CDE51605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51605">
        <property type="protein sequence ID" value="CDE51605"/>
        <property type="gene ID" value="BN770_00520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="443" mass="51228" checksum="3474D732B492F576" modified="2013-07-24" version="1">MGLNITNVSLYRNHYTSAMLFMKEGTVRVTESGNTGSATDDEAWHECFIPAKTIILNDNVYPSSDIEQAIYHECGHYEWHSMFFELQKLHSADLKLLEYQEADKASKPAEKDIRWVERQAIYVSYAEIFPRPVLMPMVQEYWREIANSNDNTGKKISYVIYRISQEKQKRRSLIKARLIMLGATAAKGACNYVDGSYIEPFAFNPERLSAGETFVIGRSQFTELYEKEADFRSLISTHQFIYADGHVYVNMPSFVSQTPKGVCLTAWALSHLDECCLKFKKHYRTNHENYKIGELHSDQEYNERYGMIHAMKSAKIAGLTPEEVMMKNVAYLESFPRTPAKAMSQLVKDRCRTKREAAQRCCLSESTISRMCQDNSFPYDVEQITKIVVGLSLPPLLPAMLLETMGFTKTVMLRYYRYQCIIDCMFMDDLETVMETHRDLFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ25</accession>
    <name>R7IJ25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein YesP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51640">
        <property type="protein sequence ID" value="CDE51640"/>
        <property type="gene ID" value="BN770_00542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="299" mass="33281" checksum="3F3E8C8329689FB6" modified="2013-07-24" version="1">MSGKRISIRARRAVSGYLFILPFIIGFLCFMLLPLVDSFWMSLCRVDVTAGQGFQTTFIGLDNYIRAFTIDPEFNKLLSEEIGVMVTHTIAILVVSFVIAIVLNQEFKGRAFVRAIFFLPVILSSGVLIGLETDNTLMAGMQQMMAESSPFTLSESLMKILKLTGIGSDVLDIVFSLIDEVYDIVMASGIQIVVFLSGLQNVPRSLYEAADVEGCSKWEAFWTITFPMVSPLLIVNIIYTIIDFFMKTDSEVMKKINEEMTLKYNYGFSSAMAWVYFAITIVLIGASALMLKGVVSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ46</accession>
    <name>R7IJ46_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000209">
        <property type="protein sequence ID" value="CDE51313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51313">
        <property type="protein sequence ID" value="CDE51313"/>
        <property type="gene ID" value="BN770_00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="158" mass="16919" checksum="A6D6A1E502437DF8" modified="2013-07-24" version="1">MKTLQTLRKLIWSLLLPSGLLLVASLALYALTGKTEFSPELSGRVLGLGCACIGLEGCVIAVAALLHDEGKLIARLLDVIIYAAYALGLLTWLFYLVNEVNYITNILVAIDGTKISFVFLATALGFACAWVLALVCAMRCSKVLKKAEEAKREGGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ51</accession>
    <name>R7IJ51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000211">
        <property type="protein sequence ID" value="CDE51318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51318">
        <property type="protein sequence ID" value="CDE51318"/>
        <property type="gene ID" value="BN770_00380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="101"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="161" mass="18726" checksum="34D922D4BCD5388B" modified="2013-07-24" version="1">MLDAEEAYQQYRDMVYGYLIRLCRDRDLAEELTQETFYQAMKNWKRYEGKSSVGTWLCAIARNQFLRIMRKQSPLPLDNVPEASVPDFTEMVAEHSLALSAHQALHRLPEPYREVFTLKTFCELSSKEIAALFGKSESWARVTAYRAKLMLLDAMKGECKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ57</accession>
    <name>R7IJ57_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin-antitoxin system antitoxin component Xre family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51665">
        <property type="protein sequence ID" value="CDE51665"/>
        <property type="gene ID" value="BN770_00563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="115" mass="13019" checksum="3C2B616982809E47" modified="2013-07-24" version="1">MLANLKALRTAQGLSQRALADFVKVSQQSINQYENRDTEPDIAVLTRIADYFGVSIDYLVGHDPAAGELIPTNLTDAELRLILNFRQLDDDQQRSMNLLVMQMTKDNKRNAKPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ83</accession>
    <name>R7IJ83_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="9">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysS</name>
        <name evidence="15" type="ORF">BN770_00629</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 11">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51819">
        <property type="protein sequence ID" value="CDE51819"/>
        <property type="gene ID" value="BN770_00629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="13">
        <location>
            <begin position="176"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="14">
        <location>
            <begin position="545"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE51819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="650" mass="73155" checksum="E27109B4CD60D34E" modified="2013-07-24" version="1">MADYPVTPHTPALSEQEIIRRQKLQSLIDAGQNPYAVTHFDVTHHSKEITDNFESLEGKTVSLAGRMVSRRVMGKASFAHLLDAQGEMQIYVTRDDLGEDAYAAFKKDDLGDIIGVSGTVFCTKTGEASIHVKSLTLLCKSLKVLPEKFHGLVDTDLRYRQRYVDCIVNPEVRDTFRKRSRIIAAVREFLDGRGYLEVDTPVLHTVEIGASARPFRTFHNALGIPMFLRIETELYLKRLIVGGFERVYEVGRIFRNEGMDATHNPEFTSVETYQAYADYNEIMEMVEQLYEFVALKTLGTTDVTYQGQVIHLKAPWKRITMADSVKEACGEDWTTWQSDEEARAICDKRNVHVEKDATKGDCLAALFDEYVEANLIQPTFITDYPVEISPLAKRKPSNPALTERFEFFITGHEMGNAFTELNDPIDQRRRFEAQVEARKAQGINAEVDEDFVNALEYGMPPTGGLGFGLDRMVMLMTDSATIRDVLLFPTMKPLDSDKKAADAAQNAPEAAAPAEEAKAEVTPEPIDFSNVQIEPLFTDYVDFDTFSKSDFRAVKVKECEAVKKSKKLLKFVLDDGTGEDRIILSGIHEYYEPEELVGKTCIAITNLPPRKMMGIDSCGMLISAVHHENDEEKLHLLMVDDHIPAGAKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJD2</accession>
    <name>R7IJD2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase WecB/TagA/CpsF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51874">
        <property type="protein sequence ID" value="CDE51874"/>
        <property type="gene ID" value="BN770_00664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="284" mass="32332" checksum="5024AA0A2F678829" modified="2013-07-24" version="1">MAQVNLEIVSRFLAGEAGKGVFATAHEGAAQYCRKVDKREIPVCPILGVNIAVINMNWLLKYLAQNIHQLQGDYICVSNVHTTVVSYEDADYRAVQNGGLMAIPDGNPLAQEARRRGYPQIQRTTGPDLMMEVFRQSTAHGWRHYFYGSTQEVQEKMIARLQQEYPGLVIAGTDAPPFRELTPEEDALAVARINQAQPDFVWVGLGAPKQERWMAAHQGRVHGLMIGVGAGFDFFSGNVKRAPLWMQKHSLEWLYRLMQDPKRLFQRYWSTNLKFIWNATIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJD6</accession>
    <name>R7IJD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51591">
        <property type="protein sequence ID" value="CDE51591"/>
        <property type="gene ID" value="BN770_00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="3">
        <location>
            <begin position="275"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="422" mass="46792" checksum="D620B564995CC449" modified="2013-07-24" version="1">MPNFSLSDAVFENAAAKYPTPFHLYDEAGIRRNARTLKQAFAWCEDFEEYFAIKALPNPAILRILKEEGCGVDCSSDTELMLADACGFSGRDIMFSANAMPYHEFDDARRLGAFVNLDDITHIDILRQHGGIPETICCRYNPGGDFKIGNEIMGNPGDAKYGFTYAQLQEGLKRLKELGAKRFGLHAFLSSNNTDDNYYPALAKILFTCGRDLAAETGLELAFINLSGGIGIPYRPDQPATDVLAVGEGVRKVYEEIFPNGGVALKTELGRWMTGNMGWLVTRVIHEKHTYKDYIGVDACAANLMRPAMYGAYHHITVCGKESLPHDHIYDVVGSLCENNDKFAIDRALPEIKIGDLLVIHDTGAHGHAMGYNYNGRLRSAEVLYTQEGGYKLIRRAETPQDYFATLDMDECAAKLGLTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJE6</accession>
    <name>R7IJE6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase</fullName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51894">
        <property type="protein sequence ID" value="CDE51894"/>
        <property type="gene ID" value="BN770_00677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="272" mass="30087" checksum="CA64FCD40C57E8BD" modified="2013-07-24" version="1">MSKHILLVHDLAGYGKVSLSAMMPVLSHMGHHLYTLPTALVSNTLDYGKFYIQETTEYMRQSLKVWAELGFSFDVVSTGMILSAEQAALVSDFCEQSAKEGALVFVDPIMGDEGKLYNGVGEETVAHMRKMVAVADCIVPNYTEAAYLADMPYHEDMTEEEARALTIRLHEMGAKSVVVTSAKVDGENCVVGYDGTEGEFFRIPFDLIPVRFVGTGDIFAAVMLGRLVDGVPLQESTHRAMDAVRTMIDRNRDKEDKYLGIPIETCLEVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJH0</accession>
    <name>R7IJH0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51631">
        <property type="protein sequence ID" value="CDE51631"/>
        <property type="gene ID" value="BN770_00534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="151" mass="17492" checksum="E2464986D335D440" modified="2013-07-24" version="1">MLYWETPDFRYIEHFCILPALRGQRYGSHALSMLPCDRPVILEIDPPVDEIAIRRKGFYERYGFTSNPYPHVHPAYHKGVRGHDLVLMSRPDGLTDKQCRAFHTNSILKHGIEHSRFFVPAKLSEARRTGGTRERNEAKPGRKRCCANDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJV6</accession>
    <name>R7IJV6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YncF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000181">
        <property type="protein sequence ID" value="CDE50877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50877">
        <property type="protein sequence ID" value="CDE50877"/>
        <property type="gene ID" value="BN770_00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="141" mass="15678" checksum="76E21DF9A5495BC7" modified="2013-07-24" version="1">MKILVRYHDGAVPLTVLPQGDWIDLCAAETVTMHAGEFRIISLGVSMQLPEGYEAHIVPRSSTFRKWGILQANSMGVIDESYCGDDDVWGFPALAMRDTTIARGDRICQFRVMRKMDKPELVTVERLDNASRGGFGSTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK73</accession>
    <name>R7IK73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51861">
        <property type="protein sequence ID" value="CDE51861"/>
        <property type="gene ID" value="BN770_00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="510" mass="56767" checksum="238DB50DE85A0011" modified="2013-07-24" version="1">MNTASRSENTARNIGVGAVRQVVTLLLAFAVRTVFVRRLGADYTGVNGLYSNILAMLSLAELGVGNVLVYSLYAPLHRGDTGEIQHLLGYYRRIYRLIALAVALLGAAVIPFLPLIISSELPMAQLIVYYVLYLANSMASYLVIYKTTLIQADQKAYLQNMVSAAALVLQYTAQMACLLIWGSYLGYLLIQIACTLLQNAVLSHLADKMYPFLRKKQKHEPMHRKQELNDNIRSMFLYKLATILINNTDNILISVMLGTVFVGYYSNYASLTTYVTTFVSIVITGISASLGNLNAEKNSEKSYAMFRNLIVLFGAITGFCVAAYGAVVQDFIPIWVGEEYLMDTGTVAAVLFTFYLSTIVAPVWMYRETLGLFRQMKYVMFMTALVNILLSILLGHFFGVAGIIGATGLARLCTIFWYEPKVLFHRTFGRSAAAYFKAQGGLLLLNGAVMLLSLLLCAQMGHTLMWIIIKGITCAAVTALLYTLALGRTAEYRWMLEKGRSFLRKWRKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKD2</accession>
    <name>R7IKD2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51941">
        <property type="protein sequence ID" value="CDE51941"/>
        <property type="gene ID" value="BN770_00708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="277" mass="29764" checksum="1A33CA7FABDB496E" modified="2013-07-24" version="1">MSFYSYKNANPNCCPGTISGSALDGLQEKVCVQVKRVYDSAMTQEQLTKQTVTITSYAQVNNTCTCNACGCQETQETIPPTSAPVPPITFESCRSTTTEGNIRNLTVDRLCDRPCFARVRATIDIPIDILFVDSRCVEYIGKATISVNRDVLLSIPDESIVPYTLESMVSAICVSGTYLGNNQFKMTICVTTILKVLAEAEILIPSYGYCPIPPAEEFAESVCDEFFALPLFPPQSVCNSGTVATGNVSSTVRSNCNCGRGCSGSCSGSCNCANSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKU9</accession>
    <name>R7IKU9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51938">
        <property type="protein sequence ID" value="CDE51938"/>
        <property type="gene ID" value="BN770_00705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="33" mass="3671" checksum="A0A9E1EBAD849A81" modified="2013-07-24" version="1">MLPLMLGLLLFANVLVFASLMLFFGLFGGCRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL28</accession>
    <name>R7IL28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000209">
        <property type="protein sequence ID" value="CDE51312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51312">
        <property type="protein sequence ID" value="CDE51312"/>
        <property type="gene ID" value="BN770_00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="309" mass="33267" checksum="256224F10034CCF7" modified="2013-07-24" version="1">MAEGESHDRVIILAALISPDDVVLVAGFVVAVPHIDPLNIHAVVLLRAVQVHLCRIGIGLGEDTVGIQHPGCHGRRREIVAGVGIGQAAGGIHTARQNVRYTHRTGHADVADPQARIHIDVCAVEEVKLHGNRRVEQHDDTLEHARLLQFGQALKQVFLFLGDGQVAAIQAVAALGGHVEALTAITGKHDNGGVTEVSEGLALRRSHVFPRELVGTISLDQTVHSIQAQTGSFLRIPVPQGSVNREALLFKGCAQRTVAIRFGSTGAGRAITRVHRTLCKEADLRLLRQGQRAVLIGQQHQTFRLHLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL93</accession>
    <name>R7IL93_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2 3-cyclic-nucleotide 2'phosphodiesterase (Duplication)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51392">
        <property type="protein sequence ID" value="CDE51392"/>
        <property type="gene ID" value="BN770_00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005145703" evidence="2">
        <location>
            <begin position="25"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="33"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="4">
        <location>
            <begin position="359"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="585" mass="64483" checksum="8D417A1457F693DC" modified="2013-07-24" version="1">MKKLLSLLLALTMILPLVGCAALAENADPIMITVIATSDVHGKVLPINYATGEPSPNVGLSMIASMIEQVRATEKNVVLVDGGDTVQGSAMTYYYSYFAPEKDDPMMKALRLMDYDMWCLGNHEFNNDLPILKRQIEYVMSPDNGEEHSVPMSAANFVAKGTEWDSWMGVPYIVKEFEGVKVGVIGMDTPNIPAWEVESHYEGIDFRNLVPTVEHFVPILREQEGCDVVIVVAHSGVEDAVSTDGNNPADYENQVRAMINLTTGIDAVVYGHFHNTDYREDILNAEGKVVPVLAGGGGEGLGFMKLAYDPATKTVTPVTAENGYRFLADQEGLVENQKVATALAPYNEELQAYLDQPLGTATGAFSNKNISLQPTALMDLLNKAQLSAVPAQLSICAPLTSGAEVRDLIPAGDVPMRLLYQLYVFENWLYRVNMTGEQLRLWLEHATTNYTSASNPDYLGGGYYTDEIYGLYYEIHYYAPEGKRIQNMQYQGQPVAPDQVFSVVMNNYRFTGGAGFMQAAGLTPEDYSLTDMYTGDTLGNDNGQVRNILAQYIRDQKEITPTVESTWQFFRTKEDAIAAGAKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILI3</accession>
    <name>R7ILI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase FGGY family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000224">
        <property type="protein sequence ID" value="CDE51487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51487">
        <property type="protein sequence ID" value="CDE51487"/>
        <property type="gene ID" value="BN770_00055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="277"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="532" mass="56339" checksum="945C17A5D1721298" modified="2013-07-24" version="1">MNHDTIAAYIADGKAVLGIEFGSTRIKAVLIGDDHAPIASGDHTWENRLEDGIWTYHLDDVWAGVQDAFANLQKDVQANYGVTLTNLAAFGVSGMMHGFLAFDENGQQLAQFRTWRNTMTAQAAEKLTALLGFNIPQRWSIAHLVQAMMNGEAMVPQIHHLTTLAGYVHYKLCGKNCLGIGEASGMFPIGSDALDYDQHMLDKVDALAKTYHMPWTLREILPCVLCAGEDAGVMTAEGAKLLDPTGTLQPGALMAPPEGDAGTGMAATNSVAVRTGNVSAGTSTFAMVVLEKPLSRVYPEIDMVTTPTGKPTAMVHCNNCTSDINAWAGMLKGFADAAGVPVSMGDIYTALFTSALSGDKDCGGVVNLPLFSGEPVVGLDAGRPMLVRTPDAKLTFPNFARSLVAGAMTSLKIGMDILAKEHVQIDKLLGHGGYFKTPVAGQTILSAALKAPISVMETAGEGGPWGMALLAAYRVNRQANETLEDYLNARVFAGAKGSTIRADAADEAGLDAYTARFHQALSAEKAAIADMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMS0</accession>
    <name>R7IMS0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51927">
        <property type="protein sequence ID" value="CDE51927"/>
        <property type="gene ID" value="BN770_00695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="124" mass="13963" checksum="8A6A08F3D00BE8A3" modified="2013-07-24" version="1">MYYCTNCHRVTPERAESCPYCDKFDRLRPAEEADECRLTELDALNASVLESLLKEANVPYIARPMMGAGISAALGVTLEKFVFFVAYRDYARAQEQLEALLAPDDHAADADFADEDEESEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMS5</accession>
    <name>R7IMS5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ORF">BN770_00699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51932">
        <property type="protein sequence ID" value="CDE51932"/>
        <property type="gene ID" value="BN770_00699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="12">
        <location>
            <begin position="19"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="279"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE51932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="489" mass="55996" checksum="D2D075B67D449ADF" modified="2013-07-24" version="1">MILYNSLTHRKEPFVPRFGNKVSMYTCGPTVYHFAHIGNLRTYIMEDMLEKALRYEGYDVKRVMNITDVGHLSSDADTGEDKMLKGARREHKTVMEIAKFYTDAFFSDCQKLNIKRPDVVEPATNCIPDYIDMITVLLEKGYAYHAGGNIYFDTSKLEKYYVFNDHNEEDLEVGVRDDVDEDTNKRNKADFVLWFTKSKFEDQALKWDSPWGVGYPGWHIECSCISKKHLGEYLDLHCGGIDNAFPHHTNEIAQSESYFGHEWCKTWFHVHHLNTTGGKMSKSKGEFLTVSLLQDKGYDPLVYRLFCLQSHYRQSQMFTWENMDNAAAAYTKLLGRIASLIPAGTPVDAEKMKPYQEKFRQALDADLNTSLAVTRLYDVLKAKDLSDDEKLALVGDFDAVLSLSLLEKAAAIRDAQKATSEVHGDGEYVIIAPADATDEEQSTVRELLLSRYQARKDKNWAESDRIRDILKDMGIAVKDNKEGVQWMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I316</accession>
    <name>R7I316_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46259">
        <property type="protein sequence ID" value="CDE46259"/>
        <property type="gene ID" value="BN770_00808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447433" evidence="5">
        <location>
            <begin position="28"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="486" mass="53961" checksum="1D59154B12CF6CFF" modified="2013-07-24" version="1">MKRTTPILMLVLMLLLTAWVMPATAEANPTLLTLYEGPKTMTTSATAKVTANGNDLFVYDVMVNHEHIWNANTQPTTTPMTYFDFEGKVRIEVEMPGLPDKVESAAVIPQSWGIAPEVKDGKVSFIITEPGQYTVVFNDNVNKALHIFANPLETDVPDPDDPNVYYIPSGEWVMDAIALEDGQTLYISGGAVLHSIISVNNAKNVTICGRGIIDGSDYDAWNQPGSYARVPIDLNHAKDVTIDGIIVANSNCWNVNSYSSKHVEINNVKVISGRQNGDGFTFQSCTDHTVTNSFARTWDDSLVIKNYSGSTKGITFRNMQVWTDLAQSMEIGYETDKGWTLDPEISDVLFENITVLYNFHKPVISIHNSDDAYVHAIVYRNIVVENAFMQGDNGNNKELIEMTLQNSAWSTVKDEFGSIDDVLIDGLTVLRTLDGKVPASRLSGYGEDNRITNVTLRNVTILGEKMTNLKQMKLRYDDYCEGIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3P8</accession>
    <name>R7I3P8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46230">
        <property type="protein sequence ID" value="CDE46230"/>
        <property type="gene ID" value="BN770_00790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="74" mass="8377" checksum="188DD21760D89352" modified="2013-07-24" version="1">MRCSCKECGTYMIQAESDHLGCVCPDCGYRCNDCLGTNTVVGRESLKALAFDPRFDPDTIFREAFLNQEEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3Z4</accession>
    <name>R7I3Z4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative N-6 adenine-specific DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46196">
        <property type="protein sequence ID" value="CDE46196"/>
        <property type="gene ID" value="BN770_00775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="46"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="330" mass="36562" checksum="1A6C9953642BE365" modified="2013-07-24" version="1">MSDKPIDADCAGKLTILPGERVDELQQAGLRILQKEQGFRFGMDAVLLSSFVRAESRDRCADFGTGTGILPLLLAGMGRAKSVDAFEIQPDMADMARRSVLLNGLEHIIRIHALPVESADEVLAPGSIDVIVCNPPYGHHGTTLPNPAQTLSLARHQQKSGLTAWFKMAYQLLRGKGRMAVIYPAARMLEVMKDMEKAGLAPKRFQLIYPSAQKAANLVMIEALKDARPMLHPEPPLMIYEPDGTLTAPLRKIYAMERASGVHAGDGEIQHARERHPQQVRHEQPSGEGLLLPEMHRHDENQAEQQNQPEEGKPKRFQDKEQHGPHQVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I423</accession>
    <name>R7I423_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000011">
        <property type="protein sequence ID" value="CDE46390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46390">
        <property type="protein sequence ID" value="CDE46390"/>
        <property type="gene ID" value="BN770_00852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021338">
        <property type="entry name" value="DUF2953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11167">
        <property type="entry name" value="DUF2953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19854" checksum="25E0411A020C05E4" modified="2013-07-24" version="1">MWISLLTLLLLLVTPISCRAEIRQEHGTRFRILLRIWGIPLRFDHSQAPMRPKPPSAQQLQKGKALLRALPKLKRPVRMLMRQTALEQLLVHVSLALRDPAATALATAFLRQIRLLIPVNCREKVRIAVTPDFLHEQTVLAARCIIFLHLGTIIVAAAMALTAWKEASSWNIPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I476</accession>
    <name>R7I476_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46450">
        <property type="protein sequence ID" value="CDE46450"/>
        <property type="gene ID" value="BN770_00868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="11"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="275" mass="31161" checksum="68B60B703DA3DEC1" modified="2013-07-24" version="1">MMVLYPYGLRKALTLSYDDGVETDIELIRILDEYGILATFNLNSGWFAPEGTVYPAGTIYRRMSESAIKALYAGGRHEVASHALTHASLSAIPAPSIAYEVLADRDNLEKLFGKIVRGFAYPYGTYSDEAVDTLRTCGIAYARTVVSTHNFEIPNEWLRLNPTCHHDDPKLDELCDRFLTGKLPFGLKLFYLWGHSYEFEQHNNWEVIRAFCEKMSGKKDIWYATNIEIVDYLNASRQLRTSADGHIVFNPTATDIWVENKGEVMTIKAGETVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I477</accession>
    <name>R7I477_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46689">
        <property type="protein sequence ID" value="CDE46689"/>
        <property type="gene ID" value="BN770_00994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="251" mass="26975" checksum="220C56D10B163816" modified="2013-07-24" version="1">MLDIQHLSFAVTNEAAGKEILHDITLTVDSGRFVVITGPNGGGKSTLAKMIAGIEKPTAGKILLDGTDMTDLSITDRAKLGVSYAFQQPVRFKGITVLDLLRIASGKRLSVSEACAILSEVGLCARDYVNREVNGSLSGGELKRIEIATVLTRGTQLSVFDEPEAGIDLWSFQNLISVFERMRQVRSDRTILVISHQERILNIADEIIVLAEGKIVSHGSRAEILPTLLGTPSAVSACAQLEKTTGKEGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4D1</accession>
    <name>R7I4D1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000008">
        <property type="protein sequence ID" value="CDE46321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46321">
        <property type="protein sequence ID" value="CDE46321"/>
        <property type="gene ID" value="BN770_00826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="690" mass="78040" checksum="71916D8A400265EF" modified="2013-07-24" version="1">MDNHLVQHQQHRRQQEQHDHHRAQRAARHQGAHGGNNIDIGVQPHAERRGEETDAADENRLRGGRDRLADGLALVRSRTAVLQVARRHQDGVVHRRTQLNGRNQNRRDERQRHVRVVGDAQVCGNCGFNDGDQNHRQGNRAQHQRDNQENGDNGNQADDLEVVVGAGNEVFRAGRFADEHPALVVLFEDFVQLINLPIHRVGGNNVFRGNQHQLVFVALELAEDFVRHHAFGDARAQQRVNRQHLLHAIDFRHFVRHGDDVLLRHVRIDQHKVIRGHVKGFGQLRVRLHAFQLLRQAGGHVVILADIVVAVECRDAQHNQDDEQHLVVLRDELADARNAGQQRLVRGLFQRAVKDADDAGQQDDRAQHAEDNALAHHDAEVTAEREAHKADGNEARDRRQAAADDGGNGLADGARHCFVLVRIGLLLFLVAVPQKDGIVQRHAQLQHGGDCFGDVGNLTEEVVRAHVPQNAHADAQQEDKRQEDGVHCQHQHDAAQRNGDGDVDGFLILHQLLGIGHNRRQTGHEALLPRNFADLRNGFHRPFRRRRVIEENCHQPRVALLEDVPVFVRQNLGRNRALGDGRIADDRIHMRHVADGVLQRLLVGFAHPFRDAQGERALAELFHQDVLPLDRVKVFRQIIQQVILDLCGVHAQHRRNQHQQTDDDDGDTVLDNPPCESVHNSSSFSEIHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4S6</accession>
    <name>R7I4S6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46228">
        <property type="protein sequence ID" value="CDE46228"/>
        <property type="gene ID" value="BN770_00789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="174" mass="19317" checksum="1EC00A2DA94DDA0E" modified="2013-07-24" version="1">MNEIIKAIEERRSIRKFQPTMPAKEDLAQIVEAGLYAASGMGRQSAIIVAVTNKELRDQLAKTNAEIMGKPDFDPFYGAPAILIVLADKSCRTAIYDGSLVMGNLMLAAHSLGLGSIWIHRAKEEFERPEYQQLLKKLGVEGEWEGIGHCAVGYIDGEAPKAAKRKDNRVFWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I586</accession>
    <name>R7I586_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">BN770_00858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000014">
        <property type="protein sequence ID" value="CDE46418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46418">
        <property type="protein sequence ID" value="CDE46418"/>
        <property type="gene ID" value="BN770_00858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="314" mass="34511" checksum="43C9BAF45452D901" modified="2013-07-24" version="1">MEFIHEPVLLQEVLEWMDVKPDGVYCDGTLGGGGHSGAMLRLSGGTATLYGIDRDMTAIEAATARLREFPGFHALHGNFHDGKALLMAAGAPKLDGVLLDLGVSSPQLDRGERGFSYHEDAPLDMRMDVSQGITAADLLNSASEQELCRIIRDYGEEKWAARIAQMICEHRAKKPMETTFDLVHAVDAAIPKAVRRKDDGHPARRTFQAIRIAVNDELDPLDKAICDFVDCLKPGGRMLVITFHSLEDRLVKRCFQRLQNPCTCPPKAPICTCGKKPVVKILAHGAVAPTEEEVARNPRARSAKLRVAQKLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5B2</accession>
    <name>R7I5B2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4">2.7.9.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, orthophosphate dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47069">
        <property type="protein sequence ID" value="CDE47069"/>
        <property type="gene ID" value="BN770_01125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="9">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="8">
        <location>
            <begin position="140"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="10">
        <location>
            <begin position="238"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="598" mass="65641" checksum="EFDB93D3A16AEA36" modified="2013-07-24" version="1">MAGIRTPEPISHLQEQMPDVYQQFVDIATKLEAHYRDMQDMEYTIERGKLYMLQTRNGKRTAAAALKIAVDLVDEGVLSEEEAVLKVEPKQLDTLLHPNFDAAAVKKAPVIAKGLPASPGAATGGIYFTADEAAEHGKNKEKVILVRRETTPEDIEGMDFSQGILTVFGGMTSHAAVVARGMGRAAVVGCGALKIDEEAKTLTVGDKVYHEGDFISLDGSTGNVYDGQIATVEASISGEFARFMGWADAARRLRVRTNADTPRDTKQAVKFGAEGIGLCRTEHMFFEADRIAAVREMILADTKEQREKALAKILPMQQGDFEAMYKALEGKPMTVRYLDPPLHEFVPHVDMKEEIDELAKNLGITSEEVIHKINALHESNPMMGHRGCRLAVTYPEIAEMQTRAVLQAAIDVTRECGYNIVPEIMIPLVGSKKELAFVKSIVDETAKKVFEEQGMTLEYHVGTMIEIPRAAVTADEIAEEAEFFSFGTNDLTQMTFGFSRDDAGKFLGAYYDNKIFESDPFARLDTDGVGKLVQMAAKLGRQTRPNLKLGICGEHGGDPSSVMFCHKVGLNYVSCSPFRVPIARLAAAHAAILEKMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5E6</accession>
    <name>R7I5E6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46483">
        <property type="protein sequence ID" value="CDE46483"/>
        <property type="gene ID" value="BN770_00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="1">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="329" mass="36533" checksum="8608798E1E0F2F52" modified="2013-07-24" version="1">MAKFAIFVDLENCGAKVPTLNSILEKVKIRGDILLGKVYGYTDRFSDLKELLLSNTFTVVPSLRYGIAQKNNADIQLVVDALEVAFTNPLIDSFCIVSGDSDYTPLVGRLKSMGKFVLGISRSEAASTVFINACNEFQFLEGVSGRTVAPAAPKKHRASTEEAADEAELNKLIISILEESADTDGMYASELKGILLRLRPDFNEKSYGCSSFGKLLTKLSQRFGELRVKNDNFNMMVNLNSAESAEGRPQLTKDNWREAFAAQLQAYKDGGFERVNPSILKADILTSYPDFTERSIGFKRFSDVMKQLEKDGLVVVEMDEQKTMLIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5P8</accession>
    <name>R7I5P8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46801">
        <property type="protein sequence ID" value="CDE46801"/>
        <property type="gene ID" value="BN770_01026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="486" mass="55190" checksum="29A1A46BCF4B8CC7" modified="2013-07-24" version="1">MKQSHQNSVLFCESDLYALMQPDARELLALSDEVDFPALRGQFHGENLPEIYRRLSEIAGADLMPLCETEQQLRRKMRIPADSEVPLTHQQKRFLRENYAHLTTFTGAYEAERFLGLRAIQAMQLRDTSPGYAALGAYLFSQAMWLAWETRQNGYARVNFLARDGYFVKVAFERLNEVLRLPVETGYVRISRQAALPLQFPKAIDLLSLPLLLDMTAHTPDSLLTLLHPIATENARAALAAEMPMNQRMDARTQWNFVRIFREKGYDAEKYQQYEKNAKAYLLPMFAGKCATFDVGYNLRSETVIQRLTGADVTAYITHIDSDLPMRRGVPFRTLYGTSPYVSWVAREQFLLERGAATIGYDAHGAVLGQTDAPSSTVQQMQTDAMRFVADMADTFGARLMDMHFRPQDGCAAFEHFLHTGAIQAGAEVENAFLDGQAGGDTTRVQWRLMQTDAVQARHPLPKWMRKLQRAAIRLAHDPQSIRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5T1</accession>
    <name>R7I5T1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46836">
        <property type="protein sequence ID" value="CDE46836"/>
        <property type="gene ID" value="BN770_01044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="123" mass="13089" checksum="14CDC2C0E8D04F70" modified="2013-07-24" version="1">MALKEKALRRLGEKLTAANIPFAAGGEWLHCQLGQSAVYHTFDIVVSAADAARADKVLTKLGMRQEQPAPDGVFRCHYHFDGADVTLLAADVALETSGSAVVLGTSIPLLTESAWDAVAQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I601</accession>
    <name>R7I601_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphinothricin acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46678">
        <property type="protein sequence ID" value="CDE46678"/>
        <property type="gene ID" value="BN770_00990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19853" checksum="486E66066219E6CE" modified="2013-07-24" version="1">MLRSAKVTDTPLIADIYNYYVDNTCITFALEHSTPQIYANMIAVGKYPFLVAEADDGQLSGFIFAHELRSRGAFRWDVELTVYLRPGFEGHGIGKALMTECIQLLTRQGYMNAYSCITLPNDRSIGLHHSLGFRDIGIWEKTGYKHHAWHDVIWLCLPLGNFGGVPAEPIPLKELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6D9</accession>
    <name>R7I6D9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma-24 subunit ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46788">
        <property type="protein sequence ID" value="CDE46788"/>
        <property type="gene ID" value="BN770_01017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="539" mass="62341" checksum="968F7D3765252F58" modified="2013-07-24" version="1">MLDTERYWQEEWAARVLRWARGKTRTAQEAEDLAQSVLMEWLRAVQAQEERGACVAEPEHLLWRIARFVWCKSLRPGTYYRCEPLSEKLSAGETPEESAERQDEQRRQTAFVRRQIMRLSRIQRETLVWYYLENRTTADIARRLRVSENTVRWHLSDSRKKIREADGKMTSTEFVYCPKKLHVAINGEAYDDRLTREVLDNLLHQNILLRCYAQGQTAQELCDELGVARPYIEDAVNVLLRDELLTADGGRVRTNFIITSGAQEEARLAVYDAHKDELSREIVRQLMAHEQEIRAIGFIGCDVPMPRLLWWLIYRCTAALPNPAEMPPRPYHTDGGAYHLMGFAREPENRHYLAWDYNGPMYNDGFRWFGLQHFGNSPVQDLFELNQPHMGKLCALLIRLIQADFDPSCVTADEQELLAELLARGFLRKADGSIKPNFCVLTREQVQRLRQEVFLPIVEAVQPAWTRVCNELRTLCKASVPKHLQALADLPLHMAALAAGYMTEQIAYAYGALEKPETPEDAAMWTLVYEPEIKVTPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6G4</accession>
    <name>R7I6G4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46823">
        <property type="protein sequence ID" value="CDE46823"/>
        <property type="gene ID" value="BN770_01037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021509">
        <property type="entry name" value="DUF3169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11368">
        <property type="entry name" value="DUF3169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="263" mass="28286" checksum="C574FDF793DDFF25" modified="2013-07-24" version="1">MKNDEIRAANRKALPKFLLLTLVGAVIGGIAGYCAARYGLDQLSGILADAGAFFGTHIAPWLMVALAVVTPAVCIPMYRHAKALLASWDGEDEDTSSVIDGKLSAALWASSASLVLAFFLIAATYSVGFASFDSWESTVLIFIGIAAFLAILVESILIQQKCVDAAKKMSPEKKASIYDLQFQKKWVDDCDEAEKIMIGKCAFKAYSAVNRVCAIAAIVLAICALVFGIGFLPSLAVCIIWMVNLSVYCKEAMRYAKAGNKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6G5</accession>
    <name>R7I6G5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">BN770_00003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000001">
        <property type="protein sequence ID" value="CDE46132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46132">
        <property type="protein sequence ID" value="CDE46132"/>
        <property type="gene ID" value="BN770_00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="53" mass="6287" checksum="AED3A38D7F3B0049" modified="2013-07-24" version="1">MANAARTKVCLACTECKQRNYNNMKNKKNTPDRIELKKYCPFCKKHTVHRETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6I6</accession>
    <name>R7I6I6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_01173</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="CBJB010000040">
        <property type="protein sequence ID" value="CDE47230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47230">
        <property type="protein sequence ID" value="CDE47230"/>
        <property type="gene ID" value="BN770_01173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="12">
        <location>
            <begin position="179"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE47230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="455" mass="50138" checksum="7B8534BBA1FE1E4C" modified="2013-07-24" version="1">MSEFRGVTPPNSVEAEQSVLGAMMQDENAVLQAAEALSTDDFYQPAHREIFEAMVALHHQQRPIDLVTVDAELTRRGTLEGIGGTEYLMRLMSFVPTTANVKAYITLVSEKSTLRKLIKASQEISQECYSQQNPLQETLGHAEKAIFDIVMNRASGESLVHVRDVLYNTYANIEELAKLKGRVSGVPTGFTLLDNMLTGLHGGELIIIGARPSMGKTSFAMNIATHAALYANKSVAVFSLEMPREQIALRMLCSDARVNMQSVRQGTLREEDWIKLAKSIGPMSNSPVYIDDTAGITPTQLRSRCRRLMMDKGLDLIIVDYLGLMHADGKTENRQLEVSEISRQLKAIALELKVPLIACAQLSRASTTRDNKRPALSDLRDSGSIEQDADVVMFIHREGYYDPETADKNVGEIIIAKQRNGPLGTVKVAWLSEYTTYTDLPPSAMGGENGGDAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Y3</accession>
    <name>R7I6Y3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46267">
        <property type="protein sequence ID" value="CDE46267"/>
        <property type="gene ID" value="BN770_00816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24433" checksum="C6B563D794D566D7" modified="2013-07-24" version="1">MTQQDATLSALQHYAYCRRQWGLIFLEQQWAENAHTAEGQVFHQTAHHGPEAELRGDTLILRGVRLESARLHLHGVSDVVEFHRSPDGVALHGREGLWLPYPVEYKKGSDKTQDADEVQLCAQALCLEEMLCCAIPEGSLFYGEPRRRTRVALDESLRARTLSLLAELLENQARGHTPSVRAHKGCNACSLKDVCVPRLSRTGSVRAYMHARIAEDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I720</accession>
    <name>R7I720_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47078">
        <property type="protein sequence ID" value="CDE47078"/>
        <property type="gene ID" value="BN770_01134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="187" mass="21045" checksum="E13C5909FBC2EFD9" modified="2013-07-24" version="1">MRNVFWRQIRLLLVVFIGYLFHVTVMTQLDTTVSINLPLVILSVVIVGYPRYKAFWVGAVYGILLETMVPGVKLLNLVFYPICAMLMSLFFTDKSAARLQYDMSNHRRGRNRSVYLRTPLCAMCAALLYEAVSIIYIAMSSAELTSAFFTRALTDALMTTLTAVVLMWPLRRLLGFGAPVSKAMAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7B2</accession>
    <name>R7I7B2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2344 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000044">
        <property type="protein sequence ID" value="CDE47371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47371">
        <property type="protein sequence ID" value="CDE47371"/>
        <property type="gene ID" value="BN770_01224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="221" mass="23938" checksum="28DDA6930C1EF578" modified="2013-07-24" version="1">MAVFEKGIRLRHIGHLDIQRAMMRALRRSGLPVAYSNGYNPHILLTFASALSTGAAGKKEILDVTMAREVSPDDFLQQMNRALPPDLQLSSARALDDKHPAMMALVQAADYTLQIEDANAAAKMIAAIPDFLQQTSILAMRRTKSGMKETDIRPLLVSLSGEGTAIHAVMALTETLACKPDMLLSALSTFCGLESAPDALIIRNGLLGRDENGELTPLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7I0</accession>
    <name>R7I7I0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47590">
        <property type="protein sequence ID" value="CDE47590"/>
        <property type="gene ID" value="BN770_01301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="122" mass="13526" checksum="6757BDECBB529927" modified="2013-07-24" version="1">MSSMCYQTLSFVECLEILRQAKAVRAAFFDGHAPYVVPMGFEWFVNGMQPVVCLMMPKEGRKAEALSVCTRVCLEFEAPDAAAIQVVLAEGKAVPLHEEDGAMVYAIPVETMSGRRYFLPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7I4</accession>
    <name>R7I7I4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47595">
        <property type="protein sequence ID" value="CDE47595"/>
        <property type="gene ID" value="BN770_01305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="270" mass="29983" checksum="D1B459FE8747A00E" modified="2013-07-24" version="1">MIIDMQEAIKNKTAHPADTLADVKIAIKDLNLYYGAFHALHGINLDIERGKITAFIGPSGCGKSTLLKTLNRMNDLIPDCRVEGSITLDGEDIYGSMDVNLLRKRVGMVFQKPNPFPMSVYDNIAYGPRTHGIHRKAQLDEIVESSLRNAAIWDELKDRLNKSALGLSGGQQQRLCIARALAVEPEVLLMDEPTSALDPISTSKIEELCMELKGKYTIVIVTHNMQQALRIADTTAFFLLGDMVEVGATDQLFSMPRDKRTEDYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7I5</accession>
    <name>R7I7I5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Feruloyl esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47456">
        <property type="protein sequence ID" value="CDE47456"/>
        <property type="gene ID" value="BN770_01257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="70"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="271" mass="29660" checksum="4DB4E38AF19B7BB4" modified="2013-07-24" version="1">MNYAGILLMLLLCGAALAENTYHVEEFPIEKEDESVIAGWLYVPDGAENAPAVILCHGFNGTHRNMDGYAEYLAQRGYVCYTFDFCGGGTQSQSSGATTDMTLLTELDDLDAVVSFLAELDEVDASRLVIAGESQGGLVTALYTARNPETVRGAMLLYPGLMMADNARSQYADASEIPETVGFMQMTISGRYYEVARELDPWTEIASFDKPVLLIHGTDDQIVPISVSEKALTIYPDARMITIPGAGHGFYLDDRETACKEMEAFLNEIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Z2</accession>
    <name>R7I7Z2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TSCPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000021">
        <property type="protein sequence ID" value="CDE46632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46632">
        <property type="protein sequence ID" value="CDE46632"/>
        <property type="gene ID" value="BN770_00965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023806">
        <property type="entry name" value="CHP03905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024434">
        <property type="entry name" value="TSCPD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12637">
        <property type="entry name" value="TSCPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03905">
        <property type="entry name" value="TIGR03905_4_Cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSCPD" evidence="1">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="79" mass="8722" checksum="4D6AC0913A69094C" modified="2013-07-24" version="1">MYHYKTHGTCSSEIELEIQNGIITHCKFIGGCKGNTQGLARMVIGCKADEVAQRLEGIPCRGNTSCPDQLSKAIHEYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I848</accession>
    <name>R7I848_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47463">
        <property type="protein sequence ID" value="CDE47463"/>
        <property type="gene ID" value="BN770_01264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25180" checksum="C1C25DE71074C1EC" modified="2013-07-24" version="1">MQYTKEVEEMVCVAKGPNHGPAPIPEEGKWIQAKEIKDISGLTHGIGWCAPQQGGCKLTLNVKGGVIEEALVETIGCSGMTHSAAMAAEILPGKTILEALNTDLVCDAINTAMRELFLQIVYGRTQSAFSDDGLRVGAGLEDLGKGLRSQVGTMYGTKLKGVRYLEMAEGYVLKLALDKDNQVCGYQFLSLGKMMDAIKKGMSPNEAYEKNVGTYGRFKAEDGAVAWIDPRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I858</accession>
    <name>R7I858_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47765">
        <property type="protein sequence ID" value="CDE47765"/>
        <property type="gene ID" value="BN770_01347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="236" mass="27266" checksum="568415783781B6F0" modified="2013-07-24" version="1">MAVRIAIVEDEKSAARVLEQAIQRYGTENKVSFTFRVWHDPLLFLEEYQAEYDIVYMDIRMPALSGMETARNLRKMDRMVMLIFVTSLAQYALEGYTVGAFDYILKPVKYYDFALKLHWALEHLPEKQEATILLVSGGSKIRLRLRDLLYAETDGHYLIFHTAEGQIRQCGTISTLEADLTNKQFVRCNSCYLVNLQHIAGIKGYSLLLDNGEELKISQPRKKQVQQTYNEYLAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I869</accession>
    <name>R7I869_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48074">
        <property type="protein sequence ID" value="CDE48074"/>
        <property type="gene ID" value="BN770_01528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="184"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="288" mass="33364" checksum="A24B4C6AE5FDE841" modified="2013-07-24" version="1">MKSNMWYMRQKEEFGEDRSQGIRFYDNTQTCDYLPHWHMTYEVIMVIAEDLTVIVENERHLLHPGDIMVIPSGVVHEIHTPPTGHRYYFLLDRERLFIIDGLLAAEEALQPCVVIRKGSAPEIEQRVKTAAAEAGVARDRFGLTVARLELSRMLIDLLRRHAQEHGTELNRRVRHKEQTQMLFVDIRDYVMAHCAEDLTPQNMADKSGYSRYHFERLFYDCLGISFHEFLTRQRLTLCKQLLERTDDSITSIAGQSGFGSIATFNRVFQQYEGMSPSAYRKSGAAQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8B4</accession>
    <name>R7I8B4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VanW family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48124">
        <property type="protein sequence ID" value="CDE48124"/>
        <property type="gene ID" value="BN770_01544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PG_binding_4" evidence="4">
        <location>
            <begin position="333"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="648"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="724" mass="79963" checksum="A63EF517AE7DC93B" modified="2013-07-24" version="1">MSEFNDNRQPRRRRTQLNAAQYAGQQTLDNSIPLIRTEDAPMQPTNPPRRNPQPPPAQQSANPPMQPMGAAQPMSAVQPMRPQGMNQPGQGSQYAQSGQMRGFRGVQGTPMQPQQGWNNGVQPLDAAHQLEQFSWGQNPTSMNTGRNQPIRGGQMMPNQPMNPQRPQNPPYPQQNYGGWQQQPMYPVNFPQYPANGNGGSGGNGGGNHPPTGLGGFNPEHREPKNEPVRRKPSGQKLLKRILFCACAVAVICGLVAAGGAISNAIQEQNEREALVASVTAYDDKYVPNVYVDGIHLGGMTRAEAEEAVTAHANQQRDAWKVRLMYAGQLVREITSADLNMTVDVREALDAAWQPGHTEGSIDARKATMDALAENPYEGYSATPSGDNVVIDNILLSIAQQAYIQPVDAHIIFDYNNFNNPLTIQPETVGRYMDTTEAKNQVYQMMSSLVSGEVELTTRELQPTTTKAMLEPQIQLRATAYTPISTTSTENRNLNIQVAFERINGKMLAAGETFSFNTVVGKRTKANGFYQAIEYAYGDQRMGYGGGVCQASTTMYLAAAKANMTILKREPHSDAVGYTDYGKDATVSDNRIDFKFRNDTNSTIFIVATVMKDSRYDKSHKVCVVSIYGESLGKGVKYELETVTVQTLPAPTEPEYRKDTNHTYATYVDQEYTYRKATDGCVVESYLVKYVGGAETERKLMYTDTYKAKSEIIYVGTVERTEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8F3</accession>
    <name>R7I8F3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_01016</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000025">
        <property type="protein sequence ID" value="CDE46782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46782">
        <property type="protein sequence ID" value="CDE46782"/>
        <property type="gene ID" value="BN770_01016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE46782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="424" mass="46621" checksum="CC7E185E87A681A6" modified="2013-07-24" version="1">MTPELYGTVVILVVLVMLSAFFSASETAFTSANRVKLKTMAQGGNKRAQIALNLAEDYDRLLSTILVGNNVVNIGASSMATGLFLALLSGNQSAATTVSTIVMTIVVLIFGEISPKAIAKENPETVAVAFAPVLLVLRTIVTPINALFVQWKKLLAKLFKSAHTESFVEAEIMTMVDEAQNDGDIDEHEGELIRSVIEFNDDRDVLNIMTPRVDVTALEDTATMEEAANLLRETGYTRVPVYHEDMDHIVGILNEKDFYACQHEGVDSIVDIMKPPVYAPATLKLSKLLKLFQTQKTHMLIVLDEFGGTEGIVTMEDVLEELVGEIYDEHDDVSEESVEMADGSRVVEGGMELTELLEGMGLKDTFNAETVGGWVSEIMGCIPFVGARFETDHLRGMVTRMEKRRVTQVRIWRKEGTDGHAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8N8</accession>
    <name>R7I8N8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsH</name>
        <name evidence="10" type="ORF">BN770_01392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47856">
        <property type="protein sequence ID" value="CDE47856"/>
        <property type="gene ID" value="BN770_01392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="204"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="212"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="615" mass="67497" checksum="E003ED259B680538" modified="2013-07-24" version="1">MNEVKTPKKPLIVYYAIAILVVLLINTLLVPMVSQARVKYVDYGTFIQMTEEDKISEVQVQDNQIIFVTKEDEANKNAVYYRTGKMDDPELTSRLSEHGVRFDKEIVEETSPLLSFLLSFVFPIVLFIALGQLLTRQMMKRMGGGKDAMSFGMGNSNAKVYVKDSAGSIKFDDVAGEDEAKENLSEIVNYLHDPSKYRDIGASMPKGILLVGPPGTGKTMLAKAVAGEANVPFFSISGSEFVEMFVGMGASKVRDLFKQAKEKAPCIVFIDEIDAIGKKRDGGKFGGGNDEREQTLNQLLTEMDGFEGSNGVIILAATNRPESLDPALTRPGRFDRRVPVELPDLQGREAILRVHAKKIKTEPNINYAQIARMASGASGAELANIVNEAALRAVRNHRTAASQADMEESIEVVIAGYQKKNAILTDKEKSIVSYHEIGHALVAALQSHSAPVQKITIVPRTSGALGYTMQVDEGNHYLMTKDEIINKIATLTAGRVAEEIVFGSITTGASNDIEQATKLARAMITRYGMSDEFGMVAMENVENAYLGGDTSLSCSAETQARIDALVVSIVKEQYQKATQILTENRAKLDELAKYLYEKETITGEEFMNILNKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8P1</accession>
    <name>R7I8P1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000028">
        <property type="protein sequence ID" value="CDE46882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46882">
        <property type="protein sequence ID" value="CDE46882"/>
        <property type="gene ID" value="BN770_01068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="30"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE46882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="197" mass="22316" checksum="268B543521323BB0" modified="2013-07-24" version="1">MPDLSWELFERQVSQCQMCGLCQNIHHKVPGQGDRHSPLMLIGEGPGQVEDEEGLAFVGPAGQLLTKMLAAISLPRDRVYICNVVKCRPPQNRVPTDEEAAACKLHLRIQTALIRPKVIVLLGSTAAKNIIGADIRITRDRGKWFERKGIWMMATYHPSALLRDPSKKRDAWEDMQSLRDRLMDLGLYNDIYQEQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Q1</accession>
    <name>R7I8Q1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ORF">BN770_01406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47871">
        <property type="protein sequence ID" value="CDE47871"/>
        <property type="gene ID" value="BN770_01406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="186"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="270"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="386"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE47871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="461" mass="50358" checksum="AE6EC548C504AE7A" modified="2013-07-24" version="1">MGKYFGTDGFRGEANKELTADHAYRVGRFLGWYYGECKRRNGDHTRPRIVIGKDTRRSSYMFEYSLVGGLTASGADAYLLHVTTTPSVAFVARLDGFDCGIMISASHNPYYDNGIKLINGQGEKMDEDTIALVEAYLDGHLECFGQTWDEIPFAHQEQIGCTVDDVSGRNRYVGYLISLGLYSFRGRRIALDCANGSSWNIAKAVFDALGATTLVINAEPNGLNINRDAGSTHIGGLQKFVVENHCDVGFAFDGDADRCLCVDETGMEITGDHILFICGRHMKQTGELLGNTVVATVMSNLGLFRALDDLGIASAKTAVGDKYVYEYMTKNNCRLGGEQSGHIIFSKYASTGDGILTSLKVMEVMCAAKKTLHQLASDLTIYPQKLINVRVKDKKAAQADAKVQEAIRAAEKKLGDTGRVLVRESGTEPLVRVMVEAQDAALCAQCCEEIAQTIRAQGWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8U7</accession>
    <name>R7I8U7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47921">
        <property type="protein sequence ID" value="CDE47921"/>
        <property type="gene ID" value="BN770_01434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="1">
        <location>
            <begin position="321"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="410" mass="44613" checksum="104F8D096ACF45C3" modified="2013-07-24" version="1">MTNRMPELLCPAGNLESLEAALHFGADAVYGGMKQFGLRAFAGNFDEDALTQAVEKMHGAGKKFYLTMNIFPFDDQLDDFIAAAKAARDIGVDAAIVSDLGAIAALRREVPELPLHVSTQASTVNAEAVRVYRDMGCERVILARETSIARAKEIIRRVPEMEIETFVHGASCMAYSGRCLLSAAMAGRSGNQGECAQPCRWHYSVVEEKRPGEYMPVCEDENGTYIFSAHDLNLMPLLPELVDAGIKSLKIEGRMKTAYYVATVTAAYRRALDLLAGGGDFAAALPGLMAELSCASHRDSDTGFALCKPEAPGGADGFHQEREYLAHVVEGSHDGRGTRFLLKNRFKAGETIELLTPSGVHAFEATPFLREKTGEIVDTLGIGGEIIRMDVPFATETGDFLRGETRNHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I900</accession>
    <name>R7I900_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48090">
        <property type="protein sequence ID" value="CDE48090"/>
        <property type="gene ID" value="BN770_01536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="8"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="257" mass="28072" checksum="6F0F664FAF30D825" modified="2013-07-24" version="1">MNIRCFCCMGDSITSDQVSGIGTMVAHRLNAQEVLNAACGYATCSDWHEGDRNITPVTLIEPPNTNTADNVLSNQVRRVLQALTPKGSIIRWTVDGIEYAIPAEIGIGTGTLTAPDVIYIAISTNDGNQPENAPADDFAAVCELPYAALTRTSMASALLWAVRTLQTVCPNAAIFLATPLQTYTPQAWMDEAHGLLKRRVIQKVAQKTGVHCIDSFYGSGFDRSVARSHGEVHPDEEWKIRIADFVTKEIESTLYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I921</accession>
    <name>R7I921_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 16">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BN770_01483</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 16"/>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48001">
        <property type="protein sequence ID" value="CDE48001"/>
        <property type="gene ID" value="BN770_01483"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 16" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="18">
        <location>
            <begin position="349"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDE48001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="424" mass="46142" checksum="445F13ABEAAAEDA8" modified="2013-07-24" version="1">MKEVVIGFLGCGNVGGGVWSLLTGFSREIAHRDSLSIRIKRVLVRDVNKTRACGVPHELLTTNADDVVSDPEISIVVEFMGGEQPATDYMLRALENGKTVVTANKVAIALNWHRLQAAAQRNHVGLYYEASVCGAIPIINTLMQPLQANRIDSLMGIINGTTNYILSRMYENGEDYEAVLHDAQQLGLAEPNPSADVEGLDAAYKLSIMASLAFHARVPFSKVYREGITKITAVDIAYAREMGYVLKLLAIAKRSGSTIEVRVHPTLIANDHPLSQVNGSFNAVYLHGHACKEMMLQGRGAGDLPTASAVVGDILHAATVDVHVHPTFVNSANADASLVFTNDWKTRYFLRLSIQDEPGSLAKIATWLSSEQVSIATMMQKAELAGSRVPLIIITHEANEQAIRAALAKFDPEVCTVENMIRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I989</accession>
    <name>R7I989_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48061">
        <property type="protein sequence ID" value="CDE48061"/>
        <property type="gene ID" value="BN770_01520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436296" description="Lipoprotein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="285" mass="30621" checksum="879E7BA6458AD371" modified="2013-07-24" version="1">MKKFFALALALVLALVLALSLTVASADELKVIRVGATAAPHAEILESEAVTAKLAELGYKLEVVVYEGYVLENPAVADGTDDANYFQHKPYLDSYNETASESEQLVSAFTVHYEPFAIYSKKVTSLADLQDGAHIGLPNDPSNETRALLLLEAAGLITVPEGTTAASALTKYDITAEMNPHGYVFDEVAAELLAPTLEDYDIAVINGNYALDAGLKPTTNGLFVEAADSEFATLYANIVAVRPADLDSDWLKALHTALTSKEAYDYMINTYEGGVIPTFTVEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9E6</accession>
    <name>R7I9E6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000089">
        <property type="protein sequence ID" value="CDE48215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48215">
        <property type="protein sequence ID" value="CDE48215"/>
        <property type="gene ID" value="BN770_01581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="71" mass="8500" checksum="3BE19FFD3103568E" modified="2013-07-24" version="1">MRYRRLRDLREDHDLKQINVASMLNMSQTGYSKYETGENDIPTHILIQLADFYHVSIDYLLNQTDNPERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9F2</accession>
    <name>R7I9F2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 3">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 3"/>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48121">
        <property type="protein sequence ID" value="CDE48121"/>
        <property type="gene ID" value="BN770_01541"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="190" mass="21398" checksum="80B9537BDA1CA510" modified="2013-07-24" version="1">MDTNAKLYQDMTKILVKREDIQKAVAQLGREITHDYQGRDLVMVCILKGASVFFSDLIREVDLPVTLDFMALSSYRNSTKSSGVVNLEKDLSVSIKGRDVLIVEDIVDSGNTLFYLGKYLMGRGASSIRIATLLDKPDRRNPEHNLTVDYHCFKIPDEFVVGYGLDFAEKYRNLPDIGVLDSRVYGAAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9V3</accession>
    <name>R7I9V3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48236">
        <property type="protein sequence ID" value="CDE48236"/>
        <property type="gene ID" value="BN770_01587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="179"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="363" mass="41867" checksum="A3DE68835AA5344D" modified="2013-07-24" version="1">MDHTQYSTNKAERKPGKHLTREDRGTIEAMKKLVQSNRAIARYLNCSPTTVSNELKRGMRPRTGRRGRTPGYSAKRGMLVYQTHRANSHKPHRICKCSAFVQWAVNKVRQEKWSLDACVGYARKHELFLPTEMVSTKTLYNEIWAINLVLQPLELPDALKRKKCCKSTAKRKKAYGATIDERPEITSSRLEVGHWEGDTVVGKRKGKEAVILTLLEKKTQHYLAIRIPGKTSEAVNAAMQKLREDFGESFFSQIFKTITVDNGPEFADFAQTEQFGTKVYFAHPYTSWERAQNERQNGMLRRYVPKGVSIENFSDEEILWAADALNGLPRRNLGYYTARWRNCLRLSWIPFTQPERLRKPQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9Z9</accession>
    <name>R7I9Z9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48286">
        <property type="protein sequence ID" value="CDE48286"/>
        <property type="gene ID" value="BN770_01619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="PTHR11596"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447725" evidence="2">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="180" mass="19270" checksum="020D3E95961C2199" modified="2013-07-24" version="1">MKKFLAILCALVLCLSCATAMAEGESHPKYVFMFIGDGMGNPQVTATQYYLGSIENPDSKFPVPADLSFTKFPYLGLVTTYDSSSFCPDSASTATSMASGKKTLSGVINYDETLTNPFSMAVSHIMNNKAGLSYTSYAHTGLQIPVYAYGVGAEKFSGLYDNTGIFTRTMDAMGLTADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAF2</accession>
    <name>R7IAF2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000122">
        <property type="protein sequence ID" value="CDE48869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48869">
        <property type="protein sequence ID" value="CDE48869"/>
        <property type="gene ID" value="BN770_01848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="140" mass="16335" checksum="FE93A396DD4436FF" modified="2013-07-24" version="1">MLKDILTLMLAIILSFTTGGSVQDEKMNDSVFQMETIHSFDGRLRVEIDATEMMIRLDITDEERGELLYSFSPVRRLDFWGICFEADNYNLWVKSGDVGILCYEYDGETWQYNPDAVMPDYIEQESWHEKTTSAPEAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAG7</accession>
    <name>R7IAG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48253">
        <property type="protein sequence ID" value="CDE48253"/>
        <property type="gene ID" value="BN770_01600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435635" evidence="1">
        <location>
            <begin position="25"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1254" evidence="3">
        <location>
            <begin position="70"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="2">
        <location>
            <begin position="336"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="456" mass="50287" checksum="1739D91FC3599F7E" modified="2013-07-24" version="1">MKKITVILLCMAMLLSGCAWSVKAEAVSSSEDVWKTIEEAYIYAFPLVLMDATRTSATNTEEAAPGKAPVNQFMHGVALANAQFKNVVTPNVDTIYTQVWYDLSEEPMIYVHPETDRFCKVQVLDAWTNTVAVLDRAGDYAITRSTWKGDLPDNVTRIDVPTAMAWAITRTVLSGEADLPNVYAIQAQMQLLPLSVYLSGEAYQPPKGSYREENSYVPINKVLSLDPVTFFNKANTLMEDNPPSAADAEILEKLAAVHVGPGMEFDASVLTGDIQANWREMLQGLRPKLAAEGMKFSKQLGQWSYFGAPIGDFGTEYAYRALVAIAGLGANTVEIALYPKTEKDADGNPLTGEKSYNLHLESDPQVLDGGFWSITAYGDDDFLIDNLLDRYCINDRSGLKRNDDGSVNVILSKDAPADTTNWLPVGEGGFHLFMRIYTPDMEALKTWTVPTITEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAJ4</accession>
    <name>R7IAJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000053">
        <property type="protein sequence ID" value="CDE47537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47537">
        <property type="protein sequence ID" value="CDE47537"/>
        <property type="gene ID" value="BN770_01277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="491" mass="56756" checksum="B880E38B661B9400" modified="2013-07-24" version="1">MNRERYLQEIDAVNAAGKYHPTWESLSTHPVPDWYREKRLGIFLHWGVFSVPAYHDWYARNMYIKGSPEYEYHCQHYGQPKDFGFKDFIPQFKMEAFDPQAWVKLFREAGADYIVPVAEHHDGFQNYRSELSHWNAAEMGPHRDIMGDLLVEAERAGMTLGASSHRVEHWWFLGHGQEFDSDIKQPMHLGDYAWPAMPERENQDLFSEPMPTDEFLTDWLLRCCEIVDRYHPRILYFDWWIQHSAVKPYLQRFAAYYFNVMESRGGCVINYKHDAFPFGIGVPDIERGQFAEAKPFLWQSDTSVMRGSWCYSVQPDKAVYKAPQEIVQDLLDVVSKNGRLLLNFGPKPDGTLADKDVEILHKLADWMRVNDECIHGTGLWRINQEGPTKIQEGQFADGASRNFTSEDFRFTCRGGNIYAACMACPADGKLHIRSLREADASHLPLWHGIVRKVEVLGNPAQVAWTRDGEALHVDLGDYQSDMPVVVKIITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBA8</accession>
    <name>R7IBA8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ORF">BN770_01355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000062">
        <property type="protein sequence ID" value="CDE47777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47777">
        <property type="protein sequence ID" value="CDE47777"/>
        <property type="gene ID" value="BN770_01355"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="17"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="273"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="375" mass="42284" checksum="10E7791AA52E40D5" modified="2013-07-24" version="1">MTQPFSYELKHICKQSGARLGVLHTPHGDIQTPIYMPVGTAACVKAMTPREMEEIGTQILLSNTYHLHLRPGEDLVQEAGGLHNFMDWHKPILTDSGGFQVFSLAGIRTIKEEGVTFQSHLDGSRHFIGPEESMDIQQKLGSDICMAFDVCSPYPCDYNTAKINMERTHRWAERCKKHHTKEDQALFGIVQGAFYKDLRIESAKTLADMDFIGYGIGGLSVGEPKPVMYEMLDEIAPYMPVNKPRYLMGVGTPDCLLEGVLRGVDMFDCVLATRIARNGTVLTSKGRVVVKNAQYAHDFGPIDAECDCYACQHFSRAYVRHLLKAGEITGGRLASIHNLRFLIHLMEQIREAIANDCFLDFRKEFYSKYDMSRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBK8</accession>
    <name>R7IBK8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000122">
        <property type="protein sequence ID" value="CDE48866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48866">
        <property type="protein sequence ID" value="CDE48866"/>
        <property type="gene ID" value="BN770_01847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="298" mass="32814" checksum="B75BF4D11335A128" modified="2013-07-24" version="1">MPRRKFDTTQRGISDTHTDAPIATSICENKLVYAERIRTLRAAANLSQGELAEAMNLGRAAISNWETGRTRPDIANIPRLCNVLGITVAAFFSDTPEEAGWNDAERTLMRNYRKLSAINQELLSATAQTMVALEEQYPGLPKRPAAPKLTPEPARLELLELPYADDPVAAGTGDSGFAASGHTTFLHATPDTRGADMVFRVNGDSMEPKYPDHCNVLVKFTDEPLGSGDIGIFQVDGALYIKQYQSDGLHSLNKHFKIMRRKSYDEIKTIGRVIGILPDSDFATSAEIQDFQAQESQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBT5</accession>
    <name>R7IBT5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48951">
        <property type="protein sequence ID" value="CDE48951"/>
        <property type="gene ID" value="BN770_01881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="154" mass="17357" checksum="5923C177B72DD45B" modified="2013-07-24" version="1">MLTYHPTTEAEKEAICACQYPGEYAMYNNPPYAEQKKHGYGFANPANNFYSFYDGETLVGFVNLSDEGSEVFFGIGAHPDHCGHGYGTQMTALAWDLSQRLYPGKPMYLEVRTWNTRAVRCYEKAGFRVVGEPVKRVTLSGEGTFYHMVRQAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBV7</accession>
    <name>R7IBV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase/succinate dehydrogenase flavoprotein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48758">
        <property type="protein sequence ID" value="CDE48758"/>
        <property type="gene ID" value="BN770_01812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447779" evidence="4">
        <location>
            <begin position="25"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="5">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="581" mass="60686" checksum="BD58BD15DF8562A7" modified="2013-07-24" version="1">MKKLTALLLSLCMVLTMACATALAEVKTASATAEGFGGGNVTVTLSVDGDKLVNVEIDATSQTDSIGGAAAKVLAEQMLANNSVEVDGVTAATVTSDAVKAAAAAALAELGLTNADLAKVEAAEKETYTDLTCDVLVIGTGAAGGAAAMAAAEAGAKVIAIEKLATIGGTSAMAGGGIAAPESSEQKKYGIEDTCEAYVDLWVEYNHNEYFREDSGMDEDRIRFVVGQAAGLIDWLEENGFEFGRPMSFDLIEGVDRFHYASNGKPTDLLYAKNQELGVEYWLETKATALLTDENGNCIGATVEKDGQTFNIYAKGTVLATGGFGNNQEMMERFTPVDAAQVAYFYGSAGQTGEGILMAEAIGAAVYEKGARLGMSYVVGDGTNAELTSLGGPWSQAPIVDNTGVRFVNEYCHSLNYPSLIYRHAAPYYCIYGSDREDYAAILANNVDDPAVTSADTLEELADKLGFDKQAFLDCIAVYNAAKETGVDAAFGARVDFMNFATVGPFYAVQIAPQYTGTIGGVVTDTSAQVLRADGTVIGGLYAAGEASNGALYDLVYMSGSSFLNALSMGRIAGENAANQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBY3</accession>
    <name>R7IBY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48022">
        <property type="protein sequence ID" value="CDE48022"/>
        <property type="gene ID" value="BN770_01498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447784" evidence="4">
        <location>
            <begin position="27"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="696"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="811"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="926"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="1148"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="1261"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="1370"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="1484"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1614" mass="171426" checksum="C669FCAB7E5CF692" modified="2013-07-24" version="1">MRMLGKRFLSLLLALGMLLMLLPAAAASELTMLQVDFLGMYATSAGTYESRKFTGDFTVMQNGEAVGTIRLTDFGSDPISVPGTGNVQLVPVAETMPEDAVMAASYTVSIVDGRLNKAVIAVLTDTGLFTVHTESSSSFDLINERGETILSFDTDSRGDYALPAAIHTGLYTLRMTKASLAIESWRDKIINIERYTGADSVTKVNASYYYVPPTMAPTATPEPTPTPTPTPTPTPTPTPTATPTPTPTATPTLAPTEAPTENPTEEPTEKPTEAPTPTPTATPTPSPTPTPSPTPTPTPSPTPEPVDGTLTMLMRGVNAAVAYQIVSEDGKTTRTGYLTDGETVQEADLFHGTYAVTVTLPEGTLLTGVNGWPNLQKGQAQWLVNIQAMQTSRYELDLTLSGGMTGSIDDLSAPAEVTISGQRMSEQMTVSGAFALNDLYPDTYQITAALPRGLYDTEGWTLSTTDTGVTASILVEIGAGETVVLPALANHATGDASGVVLGLDGQPMSGVQVQLVNQAGEVAAEAVTDENGAWQAEFLEYGTYVVRYDAGVTLANGALVISDEPATVTAKAANPAALTIHAFRDNDNNGSRGKYEEGVSGATMSLITEVNGVEVVVASGETDKNGEVSLAVPAGTYVLRSELPAGFGHGAHGKNVSANMSIMDETTEQVQSSVPLTLEAGSVTDVGVGVMTMAALQGLVWLDENDDGVYQDGEPGQAGIKIRAVGVKNGLVYETESGEDGKFYIGQMRYGTYNVEYSLPDGLVFARYSQTGGNRRSIITSEFKRSETDQVILERGDLEEVLLGVMKGSDINGICFLDENNNGVYDESEKTLEGVKVVLYRQAIGKELLNTVSDENGRFTFANIRGSTFRVKATIPQGYVYTIEGEGEYGNMFAPGTDRREHTISDVVLENDSEMTMAIGAITYGSISGTVYLDDDFSGSRMDAEKMVNNFTVTLTDENGNTRTAKTNRSGVYTFDDLAPGQYTVSATANRGLAFTRTGDGNILRNLSGGAGESEPVALTMGADLTGLDIGMITPGHVSGVVFADKNDNGLRDADEGGLLGAVVHLMDETGDVATRTIGADGSFLFDAVLPGTYRLRYELPGDGVFAPLTDGGNTIAPDSDGTTDSFTIGVGEEVTAPLCGALALGDIEGVVFADHNGSGAQDANEAALAGVTLILTPSREDLTEQTVLTDATGAYSFTGLRPDTYTLTLRFPEGMVLSKLDGNVTLPLMHGLNEQQVSIEIGLGEEWLNQALGGVIPSKMSGQVWVDENDNGRMDAGEITPENETLTLLDETGAVFAQVQTDADGRFAIDGIAPGVYSLVYDLKEGTQAARLGDSTFTTEGSQLVMTEIEISENNNYTAPMLGLKIDTSIGGMVWCDNAGEIAPLSGAEVVLLDEKGSELQNATTGEDGIYRFDGLMPGNYRLRVTLPNGYVVVEKDDTRLKDGQNISVMTTYTAREGESDLIALRMSQHQLEQNIGAVQPGTLGDFCWLDLNGNGLQDAGELGLGDMRIELWRNDQLVAETTTDAYGYYTFENLYPGVYTLKPIYPAEVVPTRMRTDIPLIASILGENGESNPVQVTSASTTYTADLGFVLVDDDMLPANYGIGEKQDWTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICD0</accession>
    <name>R7ICD0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48953">
        <property type="protein sequence ID" value="CDE48953"/>
        <property type="gene ID" value="BN770_01883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024131">
        <property type="entry name" value="UPF0489"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12640">
        <property type="entry name" value="UPF0489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="253" mass="28203" checksum="F396B6E06B1C6323" modified="2013-07-24" version="1">MGYNRTKIPLISAERSITMRVLDIDLDFFLADCCPLAELGHRPSLPGHEPWEASAVRAFLENQCGLSRTAPKPGRIFETHDQALTFWEEQIAAGRLTAPFDVTHVDAHSDLGIGYPGPNFVLFNVLSMPVPKRLDYAAFYAQKKLDEANYLLFALAMRRISSLDNVRNPRSRADIPQVLLDADGNIHLNSLTAQMFAAKNGAEPTVPFRVYDDYRDFRAAGAYDFVTLAISPRYAPKEADGLVEVVGEYIRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICI0</accession>
    <name>R7ICI0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49206">
        <property type="protein sequence ID" value="CDE49206"/>
        <property type="gene ID" value="BN770_01938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="139"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="285"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="6">
        <location>
            <begin position="422"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="633" mass="71658" checksum="12DEA05ACEE51433" modified="2013-07-24" version="1">MTAQIKMTRKEAEVQMACFRQTFSSVRLLNEKAVLHAPQAHSKRTDLECRVLHEKRQLTTLDVTPQRAEQIFARYVEVDGEPCVLELVQDLQQDTPEAVVQRRQMLTQTGSMGEKLYRDALTGLYNRRYYEDALKKRGMEAGVAVLDMDGFKACNETYGHQAGDKMLEAAVGVMRHCVRRSDTIIRYGGDEFLLLLPHIEEATFQQKLQDICCQISETRLPGLEDIRLSVSIGGLINRGEPIDCAVERANQLMMQAKKSRNAVVTDSEIAAEDIAPRKDTRPRMKILIVDDSRTNRAILNGLIPDRYDVLEAADGLEGLDMLRRYGTEIALVLLDLLMPTLSGFDMLSLMAANQWLEEIPVVMISSENDADTIHRAYDLGVSDYITRPFDADVVSQRISNTIKLYARQRGLSNQVRDQIHEKERSNRLMLEIISEVVSARNGESGAHMRHLCLLTEVLLDTLVSKTKRYTLTPHERKIIVTASAFHDIGKMGIDEKILNKSGQLTEEEYIVMKSHTLIGASMLARLDHYRDEELARTAYQICRWHHERYDGGGYPDGLKGEEIPIAAQVVSIADAYDALISPRVYKEGFSHEQAMQMIRNGECGAFNPLLIECLEDSQSRIRYLASMTAERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICP5</accession>
    <name>R7ICP5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49659">
        <property type="protein sequence ID" value="CDE49659"/>
        <property type="gene ID" value="BN770_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="355" mass="40868" checksum="76510C0C3397A976" modified="2013-07-24" version="1">MTDEAVSRRRENAAFFLRILAFGLIFTLISCAVLYVLTPKYDYGPGSMMNLPLQPRNTIDVLAVGTSTTYAAVNTNVLWANWGFSVYDLASAEQQYWHTYYYLEQALTTQHPKILLLDAKAATYPDDTTRRGRTILSTSGILNPIRRANAIAAGGQQPLDFLLGYPQVHENWKSLTAENFAFPGWTGGRSVDWKGFIECDKMEHHTKPTFFWTETGKKINGREAEYFERICDLCEAQGIQIILISYPSPDYENEHMYICTLRKMAEERGIPLLNFNNPKGRFGIRYSSDFADWQHLNVKGSIKLSLRIGKYLEENYDLIDHRGDPQYDSWQRCLEEWQAAYPEMANMIRNETEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICV5</accession>
    <name>R7ICV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49719">
        <property type="protein sequence ID" value="CDE49719"/>
        <property type="gene ID" value="BN770_02101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="49"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="395" mass="43266" checksum="900C1AB8CC801451" modified="2013-07-24" version="1">MALDSLRFAHRFDQISGSAIREIFKMIAKPGMISFAGGNPAASALPDAECAEIARDVLQKDGKRILQYGATEGYPPLLESLHAYVEQQLGCTVPAVLPVTGSTQAMDLLCKALIDPGDVILVENPSFLGNMQCMRLYQATLVPVESDENGIIPEKLEEAMRQYHPKLLYTIPTFQNPTGITLAADRRKPIAELAAKYHVVVAEDDPYRDLRYAGEACPSIKSFDKDGWVVFLGSFSKIISPGLRVGFMAGDAGILRKCTVGKQSTDVHTANLTQAIVDQYLRRGLLPDHITSICRSYKAQLDAMLSELSTFPKGTTYTRPDGGLFIFVTLPEGIDAKVLLEQAVERHVAYVPGTHFFCDGGHENTLRLNFSNSSIAQIHEGMSTLREIFAQALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID01</accession>
    <name>R7ID01_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribulokinase/uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000108">
        <property type="protein sequence ID" value="CDE48432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48432">
        <property type="protein sequence ID" value="CDE48432"/>
        <property type="gene ID" value="BN770_01697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="1">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="206" mass="23675" checksum="3C22083613E4AC81" modified="2013-07-24" version="1">MPLFRQHLAELLDGREVLLPTFSFKLGKRNPGGTPVRLREGQVMVIEGIHGLNPALSEGLHTDAIYRVFVSALTCLNLDDHNRIRTTDVRLLRRIVRDMQFRATPPNNTLSMWPSVRHGEETWIFPYQENADRMFNTALHYELPVLRHYAYDLLKAIPPENENYLAARRLIKTLNYFPDIDEGVLAEIPPLSLLREFIGGCTIEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID87</accession>
    <name>R7ID87_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF0313 protein BN770_02121</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_02121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0313 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49759">
        <property type="protein sequence ID" value="CDE49759"/>
        <property type="gene ID" value="BN770_02121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01251">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022946">
        <property type="entry name" value="UPF0313"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024560">
        <property type="entry name" value="UPF0313_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013704">
        <property type="entry name" value="UPF0313_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32331">
        <property type="entry name" value="PTHR32331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11842">
        <property type="entry name" value="DUF3362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08497">
        <property type="entry name" value="Radical_SAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01069">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03904">
        <property type="entry name" value="SAM_YgiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="296"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="645" mass="73966" checksum="7B5680F3D0DC1364" modified="2013-07-24" version="1">MNTLNKTFLPVTLDECHARGWDAPDFVYVCGDAYVDHPSFGLAIISRILEKAGYRVAMLCLPPWQDASAFKQFGKPRLGFLVSAGVIDSMVNHYTVAKKRRHDDAYAPGGKGFMRPDRATIVYCNRIRQAYRDVPILIGGVEASLRRFSHYDYWDDKVRHSILVDSGATLLMYGMGETSIIECANWVADGMNPAELPKMRGICYMSKTPDPTCVQLPSHQEVSTDKRKYAEAFVIQYDEQDPIRGKRMCQQQDTDRYLIQNQPCLPLSREALDAVYDLPYTRTYHPMYKAEGGIPALQEVEFSIASTRGCFGSCNFCAITFHQGRIIQSRSPESILREGQLLTQLPNFKGYIHDVGGPTANFRKPACPNQLKVGACKHRQCLFPQPCKNLQVDHEEFLSILKQLRELPKVKKVFVRSGLRYDYIMSDKNPTRFLREFCKYNVSGQLKVAPEHVCPYVLDRMGKPRRELYDAFVARYQQVNEQLGLKQYLIPYLMSSHPGSDLNAAIELACYLRDTGFYPEQVQDFYPTPGTLSTCMFYTGLDPRTMQPVFVARSPEEKAMQRALMQYKNPQNQPLVRKALRIARREDLIGYGKQCLVPPERDMRDDRYPTRPGDNPAHARKAIRHPDKRQQNSEKPQNRRQRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDW7</accession>
    <name>R7IDW7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">BN770_01801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48742">
        <property type="protein sequence ID" value="CDE48742"/>
        <property type="gene ID" value="BN770_01801"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="29"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="428" mass="46288" checksum="146D42F3F8AAD8B9" modified="2013-07-24" version="1">MPDTMFMKERMLITGGHALQGTVHISGGKNTAVAVIPATLLCDEPCTIENLPDISDVHALVDILCSLGAKVNYEPNRFMTVDPRPAEGWQVSYRDSQRLRASYYLLGALLGRRGQAEVYQPGGCEIGSRPIDQHLKGFRMLGANVEQMGGRIKAKADVLTGTDVVFDCVSVGATINVMLAAAKAHGTTIIYNAAKEPHVVDLANFLNSMGARVKGAGTDVIRIFGRDYLHGANYTVIPDQIETGTLMIAAAATHGDVELTGCIPTHMEALSAKLLEMGARVTESDDTLRVRGTLCGYRGVNIKTQVYPGFPTDLQQPMSTLLTTAMGQSIVRETIFESRLKHLTEIGHMGAHVQFVDNATAIIEGVPELYGAPVTATDLRAGAALVIAGLMARGVTEIYEPEYIDRGYEHLEDKLCSLGAEIRREKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDY9</accession>
    <name>R7IDY9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50044">
        <property type="protein sequence ID" value="CDE50044"/>
        <property type="gene ID" value="BN770_02245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014200">
        <property type="entry name" value="RNA_pol_sigma-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02835">
        <property type="entry name" value="spore_sigmaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="9">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="243" mass="27065" checksum="2D54AB3659FD9186" modified="2013-07-24" version="1">MSTLCSVVSAASAQLSALLSSLAPREIYYIGGPEPLPAPLTPAEEQSLLARLDTDGAAVRTTLIEHNLRLVVFIARKFDNTGIMLEDLISIGTIGLIKAVNTFDPSKKIKLATYASRCIENEVLMFLRRHSRTRMEVSLDEPLKTDWDGNELLLSDVLGTDPDMVSRGIEESAERQMLFAALSHLSPREQQIMDLRFGLHGHPEMTQKEVADILGISQSYISRLEKRILHRLHGELVREEGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE28</accession>
    <name>R7IE28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48817">
        <property type="protein sequence ID" value="CDE48817"/>
        <property type="gene ID" value="BN770_01836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="283" mass="31460" checksum="9E9985ED289BBA4C" modified="2013-07-24" version="1">MIRIVTESMSDFTQEEAKAADLIVMPLPIRFGMEEYWDDGVSLTQDDFYARLRVAKELPKTSQVPVEHYRKCFNRLLENPEDEVLVITGSSKLSGCYQSACIAREACHDPARVTVLDSLNATCAEYMLVDQALRYRREGVSDMQTMLAKLRDVMAHYKIIGMAADLKYLVMGGRLSPLVGKLGNRLSIKPTLKIEDGIVSKAGMVHGMAKGRAWYIEQLKECPPDPDVPVYIGGADCPETVALIKSQIEAANLGIQDIRCVKIGCLIGTYVGPELTLVAWKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEA9</accession>
    <name>R7IEA9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49663">
        <property type="protein sequence ID" value="CDE49663"/>
        <property type="gene ID" value="BN770_02083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="80" mass="9102" checksum="060CD2298ABDF4BD" modified="2013-07-24" version="1">MNEKMERLLTILQDVNDEIDFAHERHMVDDGLIDSLELMKIIVALEEAYDVRIDAGEVEPENFNSAEAILALVNSCRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEC2</accession>
    <name>R7IEC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50169">
        <property type="protein sequence ID" value="CDE50169"/>
        <property type="gene ID" value="BN770_02311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="187" mass="20719" checksum="6050F4313A8A64E3" modified="2013-07-24" version="1">MMDDKQLTEEYLDGKVVFPGKIIRVEHWHVRLPNGETALREVACHPGAAGIVALDDDGNVILVRQHRIAVGRLTLEIPAGKLDGVDEDPFVCAQRELSEETGLTADHWRKLTVLETTPGFCNERIHLYLATGLHAGKTHPDEDEFVCTLRMPLSDAVQKVMDGTFRDGKTALALLMVQQLLSAPCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEE7</accession>
    <name>R7IEE7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49781">
        <property type="protein sequence ID" value="CDE49781"/>
        <property type="gene ID" value="BN770_02131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="CBAH" evidence="4">
        <location>
            <begin position="108"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="400" mass="43871" checksum="C69BC07859F075D0" modified="2013-07-24" version="1">MKKKSTAKKVLLTILGVLLALVIVLVGTVYVIWHDEITTLLSFQQVTQRDESHKDGSVYVLNVSGGYHFDEFLAQGGASNDTELISFITNSITKGIIPMSIKTSEIACSAFTADTADGDRVFGRNYDFHETNTVIVYTNPGNGRHASYSTVDLQFLGLDSTKDVTTFGQKILTLAAPFAPLDGVNDAGVACGIFMSYQGGEKVAATNQQTDKPDLTSTTMLRMVLDYADSVEEAVELVEKYDLHDSAKTSFHYMIADSTGKSAILEWVSDSSDDDADGANRHLNVIWNDADPLSGATDWQMITNFIITPDYYTADANKPGLDRYELLRDRLAELNGVVADEEAAMGLLDAVSRRDWGNPGDSNSLTIHSAVYNLTDKTVLWVGNEHYGEEGYTFRFSLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEV0</accession>
    <name>R7IEV0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50145">
        <property type="protein sequence ID" value="CDE50145"/>
        <property type="gene ID" value="BN770_02297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448215" evidence="1">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="238" mass="26236" checksum="2D7033C876D991C5" modified="2013-07-24" version="1">MKRLTSILLALLMLVGMALAETSDDTLLGDWYGLWADTPFHLMLAENDEFQMSAGDFSCAGRWWQTEDGDYYLASPDMIGGMLLRETGSGLAFRFKQMEDMEILLARSMDEWTTPLVVRTDTPLEAFQGTWAVESARNGSERMLNLEPDEDGTPQMLCTVAGTEITLHPNQENAPDITATATWENGTLRTGTLSGWGEQGEKVIITIFQTEDGGMYATLEISVADMSGTLTLTLVPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEX4</accession>
    <name>R7IEX4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000154">
        <property type="protein sequence ID" value="CDE49873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49873">
        <property type="protein sequence ID" value="CDE49873"/>
        <property type="gene ID" value="BN770_02179"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="391" mass="42228" checksum="776220873D63BE19" modified="2013-07-24" version="1">MHSRSNAQPLLINHQKGAMALAHNGNLTNAAELREQLEKNGAIFHCTSDTEVIAYIITQERLKCGSIEQAVLNAMQVIKGAYSLVVMSPTKLIACRDPHGFRPLCMGRIGDDVVFASESCALDAIGATFVRDIEAGEVVVVNEEGIHSYKMPGACHDGMCIFEFIYFARPDSVIDGSSVHEARIRAGSFLALDHPVQADVVIGVPDSGLDAAIGYSRTSGIPYGIGFIKNKYIGRTFIQPGQKQRQDAVRIKLNAISATVKGKRVVMVDDSIVRGTTCARIVRLLREAGATEVHVRLSAPPFTDPCFFGTDVDSKENLIAAHHSVEEIGKIIGADSIGFLSLEACDKLAADSHCGFCKGCFCGKYPVDPPLVTEKNKFDQPIHGGKVQDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEX6</accession>
    <name>R7IEX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate-flavodoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BN770_00170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50349">
        <property type="protein sequence ID" value="CDE50349"/>
        <property type="gene ID" value="BN770_00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="669"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="723"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="945"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="974"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="732"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="735"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="742"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="797"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="800"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="802"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="825"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1054"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE50349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1147" mass="123229" checksum="2216E3451B5AF48D" modified="2013-07-24" version="1">MKTMVGDGNLAAAQVAYALSETAAVYPITPSTPMAENCDEWARAGKRNVFGQKMRLTEMQSEGGAAGALHGMLSAGALATTFTASQGLLLMLPDMCKISGELLPGVMHVAARALAYHALSIFGDHSDVMAVRSAGWGMLCAASVQEAADLAVVAHLSAMAGSVPMLHFFDGFRTSHEIQRFEALDEDELRGLLPRTQIQQFRARAMNPEHPHQQGTSQNPDVYFQGREAANPYYFALPEIVQDTMNRVAALTGRPMRLFSYTGVPDAKKVLVLMGSGAETAEETARALMRTGEKVGVVRVRLFRPFSAEALLTAIPESAERIAVLDRTKESGALGEPLYLDVSAALFAAGRTAKVCGGRYGLGSKEFTPAMVKAVFDALDTMEAGQHFTVGIDDDVTHLSLPIDAHFALPDEGVISCKFFGLGADGTVGANKSAIKMMSAQTDRQVQAYFAYDSKKSGGYTVSHLRIGAAPIRAPYLIGQADFLACHQPTLMNLDVVAQSVKPGGTVLLNLPDGMEIPAKLRRSIAKRHALLYAIDADAIAAQCGLGGRINTVMQTAFFQLNAFLPEEQRQQLLTESVQAAYAKKGERVVAANLNAIAKTANALRRVDVPPEWVELPDTPDDAPQSAVEAFMRPMLRQQGDMLPVSAMDARGFAPLGTSRLEKRGIARQIPQWRAKACIQCGLCSLVCPHGCIRTFYPLAETALPADFHTVRAKGKAFSGRNFRVQVSPLDCTGCENCARTCPAKEKALVMRPAAEMAQEQANWNFAVSLPETAIGEADTIPLAQAKTPLFEFSGACAGCGETPYIKLLTQLFGSHLMIANATGCSSIYAGSAPSCPYTVNQKGQGVAWGNSLFEDNAEFGFGMYLAMKHRRAHLAEQVETLAAQCPELAESCRAWLGSREDTALSAQAGEALLAACETLSHPLVKEIADSTDLLAAKSVWLIGGDGWAFDIGFGGLDHVLASGEKVRVLVLNTQVYSNTGGQASKATPAGAAARLMSGGKSGAEKDLGLMAMTYGHVYVAQVAMGANPNQLLKAMREAEAWDGAALIIAYAPCIAHGIDMRDVQEIEKDAVQCGYFPLYRYHPANGLMLDSKAPDGDFQAFLMRQGRFAALRRSDPAKSETLCKMAEEAARRRWNLLKMLKNREMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF25</accession>
    <name>R7IF25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50404">
        <property type="protein sequence ID" value="CDE50404"/>
        <property type="gene ID" value="BN770_02369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="144" mass="15990" checksum="030767E7340AA18C" modified="2013-07-24" version="1">MKRIYVNEKWCLGCHLCEYYCAFANSGKSDMVKALKNIRIHPRIHIEEGANGVHFAVNCRHCADPLCVKGCITGALTRQNGMIVIDENKCVGCFTCILSCPYGAIEPDETGRVMQKCELCTKNGAGEPLCVKNCPNQAIVYEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF97</accession>
    <name>R7IF97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50260">
        <property type="protein sequence ID" value="CDE50260"/>
        <property type="gene ID" value="BN770_02339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="436" mass="48520" checksum="50694296849DBC93" modified="2013-07-24" version="1">MTERELREKLQSAYGTMPDATRAAFEHSLTHHRVETRNSVRMSRRMRTIVTLALMLMMLTAVGVAAAKLASVTDYPPPSGLTPEYMSHLVALNEAYDGDLLTLSVNDLVFDGTTVDVAMNVQPKAGKQVFMDMEVTAECEGRAYTLEIEGCGGGDFMSGMFLPDETGSWSDSPFGFDGVLWDDDMQSPPEGAPIAWTMTFELLQPVWKVEYLPDAQYQALLAGGADTLEAYVQNNWRQHIITVTYGSLVEYQYAAEAAMLADGTITEPLSGSRTEQLLSCGGFRRADTIIVQFTTDFADDYAHPELVGKRIGMGDYDLVIDNVNLSFMRANITMHYEFPAAYTEDEICQMTNLPNAWRVYVNGETDSGYDAYANFQQVTNGAYGVDTPEQLTVGFDFYPAETDITRLTFVPIRNMGERWDACHPDAEKGFTLELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFL5</accession>
    <name>R7IFL5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50405">
        <property type="protein sequence ID" value="CDE50405"/>
        <property type="gene ID" value="BN770_02370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="5">
        <location>
            <begin position="313"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="409" mass="44431" checksum="58115E4D1FB820DE" modified="2013-07-24" version="1">MKYVIIGNGPAAVTAAETIRRADDAGEITLLSKEDEFTYSRPLISYLLCGKTDETRMRYKPADFYARNRVDFRSGVAAVSIDKDEKNVTGSDGNVYPYDKLLLATGAKPFVPPIPGLESVHYHTFMTLRDAHELADCLTKNTRVLIVGAGLIGMKCLEGIRDRVASVTVCDLAKQVLPSILDAEAAQMVQKHCEAQDVTFLLGDSAARFEPGKAIMQSGKEVEFDELVMAVGVRPATELAQSLGLDAARGIHTNAQGETDIPDIFAAGDCAKSFDVTTDTERVLALLPNATQQGEICGLAMAEKSGKSFNAIPMNAMGMFGLHMITAGTMTGDDHIIRENGSYKRLCTKDDRLMGYILVGNVARAGIYTALIREKTPLSSIDFELMLDKPQLMAFSRRDRATLMGGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFP4</accession>
    <name>R7IFP4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP_bind_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50246">
        <property type="protein sequence ID" value="CDE50246"/>
        <property type="gene ID" value="BN770_02332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="3">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="286" mass="32639" checksum="1F63B93E5A2CA955" modified="2013-07-24" version="1">MAMDLQRLMSLLRQCMQRYDMVSAGDKIAVGLSGGKDSLTLLMGLKHLQRFYPVPYKLCAIHVGSGAPGSEADVETMRQFCEGLDVPFYFVDAKVYQIVFEIRKEKHPCSLCAKLRRGALNDKAMALGCNKIAYAHHQDDFIETSLMNLMLEGHYDCFPPVTHLDRTNLQVLRPMLMVKERDVIGFARRENLPVVKNPCPADGHTRRQDVKDFIRRSRDVFPQGRECLYASLLDYFDRNVTKNAKNGQKSSENDIFGEKQQKLSKKIRKNGAFSRKKCTKRPKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG27</accession>
    <name>R7IG27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50258">
        <property type="protein sequence ID" value="CDE50258"/>
        <property type="gene ID" value="BN770_02338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="160" mass="18339" checksum="D0489E527E85EB40" modified="2013-07-24" version="1">MNEATWIEKMRAVEGTLYHVTCAMLREEYDRRDAMQETALRAWEKQSTLRREEYFGTWAVRICINVCKDIRRKSKPVMSTDDVPEIPAPQGDTDFRLMLDNLPDTLRLPVVLYYLDGLTVAETAQALGVPVGTVKFRLHQARKKLRVELDAPEGEGANVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGC6</accession>
    <name>R7IGC6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50368">
        <property type="protein sequence ID" value="CDE50368"/>
        <property type="gene ID" value="BN770_00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="125" mass="14759" checksum="42D14AB29088FEE7" modified="2013-07-24" version="1">MDKYIYDENNGLWYELQGEYYLPCLSLPPEEEKPIGIWGQRHKRYLKEHRKATYTTLLTSGKLNTYLSGINEQAQERFERLIDGMKQAQGITEQLKAENALEWVRRMNNIRACAMEIVNKEIIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGE0</accession>
    <name>R7IGE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cardiolipin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BN770_02072</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49647">
        <property type="protein sequence ID" value="CDE49647"/>
        <property type="gene ID" value="BN770_02072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE49647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="525" mass="59642" checksum="61BC556A0F08E47B" modified="2013-07-24" version="1">MNDREEGKGMRLLRKGKRGLIQAIFSRLGLIVLLFLLQLALLLGLFSAAAEFLPHFFGGAIVFNAIIVIYLLNSEGDPTAKLTWLVFFSVAPVFGALFYLYTKSDIGHRLLRERTTQLIREGRSDLRAHASAQQHLEERDPQIARMASYIAKSGCYPVWEHTAVTYFPLGEDKFAALLPTLRQAKHFIFLEYFIVEEGEMWGQVLSILVEKVKQGVEVRVLVDGTCEFTHLTHDYPRRMQELGIKCKMFAPVRPFVSTHYNYRDHRKIAVIDGQVAFTGGVNLADEYINRVVRFGHWKDTAVMLRGEAVRSFTLMFLNMWAIDEHTMESSRFLAYPTKPAMDAPGFVLPYSDSPVDGNKVGEQVYIDILSRARRYVHIMTPYLIIDHNMETALQYAAERGVDVHLILPGIPDKKYAFALAHTHYASLMKAGVKISEYTPGFVHAKVFVADDREAVVGTINLDYRSLYHHFECAAYMLDVPCIANIEADFQHTLKQCRRMTPERLKNDKLSMKVAGALLKAIAPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGN9</accession>
    <name>R7IGN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50503">
        <property type="protein sequence ID" value="CDE50503"/>
        <property type="gene ID" value="BN770_02423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="406" mass="45880" checksum="C66A186482514CCE" modified="2013-07-24" version="1">MQTIAKRAWHRLRTLAPEYALYPLIVLIVLLVMGAFTGRFLTTDNPYGSYTIQACAWLEGHLDVNPNFTWLELAEYGGKFYVSFPLFPSYVMLPFAAIFGLDTPDHFINLAVTLLGIAYALRIYRRMTGSSRYAARYVLYLYLANGYLFIALQGWVWFLAQAMCFTLSLMAADAAQHGRSGWALAWWACAVGCRPMAALYLPLLVYLLNKSGVRHSWKRQIANLLPAALIASSYMVLNGLRFGNPLEFGHTYLPEFQLAENGQFSLAYAWEHLQQLVRLPKYQGRGQPLAFDSYDCMAFYLITPMLVTFLCVYFYALIRRRRGNAFWLIGLPLMVGVHLTIIVCHKTLGGFQFGNRYLLDMLPWVYVAILALKPQSGRTSILNVPLMVMGSCINLLGAVGAYAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGV8</accession>
    <name>R7IGV8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49797">
        <property type="protein sequence ID" value="CDE49797"/>
        <property type="gene ID" value="BN770_02145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="140"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="301" mass="32342" checksum="AC4AA9AC9567D19C" modified="2013-07-24" version="1">MNWDETRDFLSPCFPECIRDELAMLLPGELREIRIRAERPAVFVTATRTAKLDWIPGQMQVEALTEALSGHSLFARADETRRGYLTLRGGHRMGLCGHITRKNGQSTLRDIASVCIRIAGEWRGCADGLISRFPALFPGKTPSVLIIGAPGSGKTTLLRDLTRQMADTMSVQAALIDERGELAACVDGVPQLDVGASTDVLDGLPKIEGVPWLIRSMAPNVIAMDELSGAEDAACVMDAWACGASVLATVHGTALAETANRPALSPLFSRRCFDLYVLLSSEGGGKITALHDRCGSPIPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH86</accession>
    <name>R7IH86_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000186">
        <property type="protein sequence ID" value="CDE50985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50985">
        <property type="protein sequence ID" value="CDE50985"/>
        <property type="gene ID" value="BN770_00258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="384" mass="42864" checksum="8379D277D3A5A06F" modified="2013-07-24" version="1">MPEGTYLTKQVQLRSDTMLWLDKNAVLLASQNYATYPHVLPCESLVAVRNTGRALVYAERARNISISGGGELNANGRCRFKVNDPKGINKLYTSRPDNLYTACCEDIRVSDVRFTSAAYWTLVPLSSRFVTLEHLMLDCMNTPNRDGIDPVDCHDLSVRHCCIMAGDDGFCLKTADRMGCRNILAEDLVIQSLASAIKIGTDSYAKVENVTVRRCILKNVNRCGIAVETVDGAAIRNCIFEDIDMTDCGGPMYMTIGHRNRKAPQFPVRVGSMAHIAFRRIGYRAPYLFSRCKTVYESLFIGDSAENKIRDVLVADCDLLLPGGCRHGVDAPQPIGEKYPEYDRHGLSSGAAFTLRFCEDVRFENNVIQTERPDVRPLVMIHDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHI5</accession>
    <name>R7IHI5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="16" type="ORF">BN770_00024</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51095">
        <property type="protein sequence ID" value="CDE51095"/>
        <property type="gene ID" value="BN770_00024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="13">
        <location>
            <begin position="22"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="133"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="14">
        <location>
            <begin position="499"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="15">
        <location>
            <begin position="577"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="10">
        <location>
            <begin position="706"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="11">
        <location>
            <begin position="1128"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1212"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1259"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDE51095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1307" mass="147095" checksum="6D76A2B181D750E8" modified="2013-07-24" version="1">MGKLRKRMSFSRINEGLEMPDLIEVQKRSYQRFLETDLKEVLADASPITNYNGNLELTFTDYSLGEPKNSVERCRERDMTYAAPLNIHVHLYDSETSEIKETDVYMGDFPLMTENGTFVINGADRVIVSQLVRSPGCYYTRTLDKAGVPLYSSQIIPNRGAWLEYETDSNDIIWVRLDRARKLCLTTLLRALGYETDDDIRNLLGNDKRLEATMAKDTTVAEASKDRGGAVRTLREQALLIIYKKQKPDEPESVESATNMFKSLFYDPKRYDVMRVGRYKFNKKLSIATRINKHIIAEDIIDPRTGEVMFRAGQVIDLETARRVQNAGVNRVVVDCEGEKRIVIGNNFVDAAEYLPFDPKEVGILEMVHLPTLKAIIDGLGEDVEEEQLKQVIADNVQHLVPKHITDDDMVASISYLLGLPYGIGTTDDIDHLGNRRLRSVGELLQNQFRTGLSRMERNVRERMSAQDGSTDYQPDSLISIRPVTAAIKEFFGSSQLSQFMDQNNPLAELTHKRRLSALGPGGLNRDRASFEVRDVHYSHYSRICPIETPEGPNIGLIGSLATYARINEYGFIEAPYRRVDKEHRRVTNEHVYMTADEEDLYRIATATEPLDENNCFVNDMITVREVTEYVQVPGDQVDFIDVSPRQVVSIATGMIPFLENDDATRALMGSNMQRQAVPLLVPEAPYVGTGLEFKAGHDSGVEILAREDGVVEKVDGNTIVIRDDLGERHVYHLTKFARTNQSNCANQRPVVSAGQRICKDDLLADGPSTEKGEIALGRNALIGFMNWEGYNYEDAVLLSEKLVKEDIYTSIHMEEFECEARESKLGPDEITRDIPNVGEDAVKDLDERGIIRIGAEVRAGDILVGKVTPKGETELTSEERLMRAIFGEKAREVRDTSLRVPHGEWGVVVDVKIFDRAHSDELSPSVQQMVRVYIAQKRKISVGDKMSGRHGNKGVVSRVLREEDMPFLPDGTPLQIVLNPLGVPSRMNIGQVLEVHLGLACRALGWHIATPVFDGATYPEIRECLEMAADTMSKPVDESNPRMMQSYFHNGRPLRLNLDEEGRRLFLDGKIRLRDGRTGNWFENPVTVGVMYFLKLHHLVDDKMHARSVGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAANTLQEILTVKSDDTVGRVKTYEAIIKGENIPAPGVPESFKVLIKELQALCLDIKVLDRDRNVIEIPELDPEDMAPPSKNNASEQDKQESLTTLLPEDEDADAISNDFPDNDFPLNDLDSDSEDDDLSIPLSFDDDEENDDLDTMRLDDLGFDDMNLDDDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHZ4</accession>
    <name>R7IHZ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="8" type="ORF">BN770_00020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51091">
        <property type="protein sequence ID" value="CDE51091"/>
        <property type="gene ID" value="BN770_00020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="7">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17634" checksum="53A31ABA3BF21AEE" modified="2013-07-24" version="1">MPRRGFVPKREVLPDPVHGTTVVTKLINQIMLDGKRGVAQNVCYEAFDTIKEKTGKDANEVFQAALANVAPSLEVKARRVGGATYQVPIEIRPERRQTLALRWLVMFSRKRGEKTMAERLAAEIMDAANNTGAAVKRKEEMHRMAEANKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7II31</accession>
    <name>R7II31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000194">
        <property type="protein sequence ID" value="CDE51136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51136">
        <property type="protein sequence ID" value="CDE51136"/>
        <property type="gene ID" value="BN770_00297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="179" mass="20731" checksum="7A9F2DB820ECDCA7" modified="2013-07-24" version="1">MQYLRRLVWYIASRLLVITLVLGLMVTGFYYAMNVTNINVVLKDGMARRAQVIMMTEDSSELTKYFQESFIQRDPQVQNAIAGYSAYKDYNIRGMDHRLEMSFFWVWPWDTVARVTIVERIPRIDGRVKGAYADQYVAEQGASALYPPAWQSMKYNAILVKESGKWHIRSLTVVEALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7II87</accession>
    <name>R7II87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartate/glutamate/uridylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51509">
        <property type="protein sequence ID" value="CDE51509"/>
        <property type="gene ID" value="BN770_00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="6">
        <location>
            <begin position="69"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="275" mass="31002" checksum="EE1864B6F3364F9D" modified="2013-07-24" version="1">MMDYQFDLVGKIGSMALIRKEDKDIDYNIFSRLGAELKPGMIWVTSGATEIGRLDYLKRTGCELCGSDDEIKADYAAQGQSILMQNYRQFIHQEYGVRQLLVEHTHFNDPEKREHIRRLLIRAAQQKTIPIVNYNDPVSDEENRKMELAIRRSHGDQVVECVDNDETAAVIANLVHAKKLVLMTSTEGIYRDPTDPKTLVEQVTAKSMEELEEKVRQLQESCVGASRAGANGAKAKLEYALKSARQGTMVIIGHARHRLSDLVEGRVACTRIGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIB4</accession>
    <name>R7IIB4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="10" type="ORF">BN770_00483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000226">
        <property type="protein sequence ID" value="CDE51534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51534">
        <property type="protein sequence ID" value="CDE51534"/>
        <property type="gene ID" value="BN770_00483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="299" mass="32225" checksum="0E271728151CACCB" modified="2013-07-24" version="1">MTIKNYSKQCLMISAGIMVLALLLSLFGMGINVGIDFSGGMSMQYTMGEAVTQSDIEGVLNGIGLKDYAVSVQGTGKDSINIRIKAIDEDGVQGVQASITEALQAKYPNAAIYGDVNYVGPVAGATLLRNAFLSVLIAALCMLIYIAIRFDFNSGAAAVLGLVHDVLIMLSFMVILRSFVQMNSSFIAAMLTIVGYSINNTIIIFDRIRENARKMPSSTPRADVVNRSIKECLGRTINTTLTTLVTIVSLYIFGVSSIREFALPIIVGIISGVYSANMINGYVWAFLEEKKRAKKAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIF2</accession>
    <name>R7IIF2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_00414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51400">
        <property type="protein sequence ID" value="CDE51400"/>
        <property type="gene ID" value="BN770_00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="53"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="366"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="399"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="604" mass="66467" checksum="38624DBBE6BA6C05" modified="2013-07-24" version="1">MSETKRRPGGHPGMRGPGVPGEKAKDFRGSLGKLVRHCKPFYPVICIAILGDLAGVIIRLIGPNKISEITNLITAGLRGEIDMPAIQKICITLIILYAVGALLSFMTGLVMTVVTQKVNRGLRDGISHKINRLPVSYFQSTSTGDVLSRVTNDVDTIGQTLQNSLTSLVSAVTMFIGSVVMMLSTNWVMALTAIVSSMLGFGLMLGIMSRSQKYFVARQRWLGDLNGHIEEIYTGHNVVRLFGAEQREQQAFDRINGKMQETDWKSQFMSGLMMPLMGFIGNFAYVAVCVVGAVLAMNGTISFGVIVAFMMYVRLFTSPLSQLAQAATNLQSAAAAAERVFEFLEAKEMPDESHLPAQTKTVRGEVAFDHVRFGYTPDKIIIHDFSEHVQPGQKVAIVGPTGAGKTTMVNLLMKFYPLGGGEIRIDGVPLSQMTREHVHDLFGMVLQDTWLFEGSIRDNLCYGKEGITDEQLDQVTRATGLYHLIHTLPEGYDTQLSDKLNLSAGQKQLMTIARAMIENAPMLILDEATSSVDTRTEMLIQQAMDTLTKGRTSFVIAHRLSTIKNADKILVMRHGDIIESGTHEDLLQKGGFYAELYNSQFEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIG1</accession>
    <name>R7IIG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter substrate-binding protein family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51579">
        <property type="protein sequence ID" value="CDE51579"/>
        <property type="gene ID" value="BN770_00498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435964" evidence="4">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="35"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="6">
        <location>
            <begin position="35"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="267" mass="29042" checksum="9D917594A1A4AB41" modified="2013-07-24" version="1">MKKLLSVVIALMMMVTFVFAEEAAPAEVKTLYAGVLTVGCEAGYPPFEMVADDGESVVGLDMDIMAAVAEKLGLQMQVVTTSFDGIFDGIGVNYDVVCSAVTITPDRMQNMLFSLPYITNYQAVVVPADKDVEINSFMDLDGYVIGVQKGTTADILMGDYESTKTINVTVVANDKLSNCFTQLTNGEIQAVVVDSGVAESYVAKNPELYKIVYQDMTEGEQFAIAMGLNDTDMQAAINQAMQELEEDGTLKEIYEYWFGADSEESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIN6</accession>
    <name>R7IIN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC-type sugar transport system permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51644">
        <property type="protein sequence ID" value="CDE51644"/>
        <property type="gene ID" value="BN770_00546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="114"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34938" checksum="5A8692753FAF9212" modified="2013-07-24" version="1">MSTINVRSYKGPVRPDGTPIELPQKVLKLTKKSNMRHKKPNRSRVGDFLVGLLLFLVACAMAFPLVFAISSSLKPLDELFRFPPTLFPRHPTIDNFSDLLVTMGQSWVPFSRYITNTVVITLVGTLGHLLIASLAAYVLAKYDFPLGKQFFALVVTALMFNGYVTAIPNYLTMTRLNLVDTHWAVILPAFAAPIGLFLMKQFMEGLPMSLIESAKIDGAKEFRIFWTIVMPNVKPAWLTLIIFSVQNLWNAKASAVIYSEAQKTLVYALQQIQAGGIARTGQAAAVTVVVMAVPILIFILSQSQILETMATSGLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIP0</accession>
    <name>R7IIP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000212">
        <property type="protein sequence ID" value="CDE51321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51321">
        <property type="protein sequence ID" value="CDE51321"/>
        <property type="gene ID" value="BN770_00383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="279" mass="32277" checksum="53DD1AE7C79379C5" modified="2013-07-24" version="1">MMGGISCAVAENANPLVSDWLTELKSKRLIQIVEDEIGEGWTLYQPNGREEEENFSSAENLKEMRFLPVVAQKDNQLRLLILRRQGDLWKVSEQNDRALMRDGWTLQNFSAMPYGNSDWTYIFFDFVDENQKRWELMLNLGDGYVSSFGTISYYVEGYGTTYINMNYDRGLEFLIDAPAYSRFSYEVYPVERYSFGVEDFDLATCPLTMQEFLVPAIVTCGEEGAGLYIMVQQDVQPIVTLADGDAIEAIPQKWELDWTIVYYQGNYLFMKTENCKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIQ0</accession>
    <name>R7IIQ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="3">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM isomerase</fullName>
            <shortName evidence="3">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuD</name>
        <name evidence="5" type="ORF">BN770_02408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50472">
        <property type="protein sequence ID" value="CDE50472"/>
        <property type="gene ID" value="BN770_02408"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011824">
        <property type="entry name" value="LeuD/DmdB_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02084">
        <property type="entry name" value="leud"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="4">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="167" mass="17878" checksum="DA1B3D37958AC213" modified="2013-07-24" version="1">MPSGKVYKYGDNVDTDVIIPARYLNAPSPDELAKHCMEDIDATFAQKVQPGDIIVGGANFGCGSSREHAPIAIRACGVSCVIAPSFARIFYRNAINIGFPILECPKAAAEIANGDQVSVDFATGTITDETTGKTYHATAFPPFIQKIIAHGGLLSYLKARQQNMEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIR3</accession>
    <name>R7IIR3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRORSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000214">
        <property type="protein sequence ID" value="CDE51346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51346">
        <property type="protein sequence ID" value="CDE51346"/>
        <property type="gene ID" value="BN770_00388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040285">
        <property type="entry name" value="ProX/PRXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31423">
        <property type="entry name" value="PTHR31423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="2">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="162" mass="18333" checksum="382165844F656328" modified="2013-07-24" version="1">MSNKARVLNHLQALSIPCAVYEHPAVFTMEECLALPYAAPDVTFCKNILLCNRQQTAFYLYVTLPDKPFRTADTSKLLHSSRLSFAPPKCLPTMLGLESGSLSPLGLWFDEEKRIQLVFDHDVKREGRIAFHPCDNTATVVFAQEVFWTQVVPTLGHEPIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIT4</accession>
    <name>R7IIT4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000235">
        <property type="protein sequence ID" value="CDE51684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51684">
        <property type="protein sequence ID" value="CDE51684"/>
        <property type="gene ID" value="BN770_00058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="214" mass="24746" checksum="29E7E30D21DCB8B1" modified="2013-07-24" version="1">MLNIVKAYLSLEMSAQDFASAVQTNDELVQFINGRIPQKQDKSAESWKQCPLNVNAFEHDNFDLRRTLTVGYYAINRISRCSTAYNMMWSLFHDDLPDVEKSTFYRELHQFAIDTVPDYLDSVDVGSVIQEIILSTNSIPKGKRQKAVRVALNSAFHLDALHKKPSWIQDSEWPLGTSNTPMLFLGQRKIKGQYVEYYFEDVINGEKRTITQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIY4</accession>
    <name>R7IIY4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51600">
        <property type="protein sequence ID" value="CDE51600"/>
        <property type="gene ID" value="BN770_00515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11755">
        <property type="entry name" value="GH94N_ChBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037828">
        <property type="entry name" value="GH94N_ChBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_X" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="797" mass="88832" checksum="C4224B7D0B33DF9B" modified="2013-07-24" version="1">MQFGYFSDAAREYVITDPRTPMPWANYLGSPEYGAIVTQNAGGYSFVKSGAAGRILRYTFNQFDEPGRYVYLRDDETGDYWSATWRPVEKPLEQYKTITRHGTSYTEVESTYSGIESKTLYYVPLGATHEVWRVAVTNKSDKPRTISVFSYCELTTESNYEQDLVNLQYTQFITTTTFHGDHIIEHINQFCGVNADGENGRERFFGLAGSPVKSYTGRRERFLGQGRFSNPKGVVDGDLGNSLNFNGNPCGSLHTVLTLQPGETKTIAFLLAQKGEKAARALLDSYANVADKVDGELKALVDYWHGELSGLTVNTPDANFNSMINTWNAFQCFTTFVWSRAASLIYCGQRNGLGYRDTVQDIQGIIHLDPKMAKERLVFMLSAQVHHGGGLPLVKFNHNAGHEDSPEDDSYVRATGHPHYRADDALWLFPTVYKYIAETGDTAFMDEVIPYATHGEGTVLDHLKRAIDFSMNHLGAHGMPAGLHADWNDCLRLGAAGESSFVAMQLYLALRLLDELMPNKPENDEYRVYLRQKAEEQKALINQHFWEDDRFRRGYSEQGSIIGSKNDPEASMWLNPQSWAVISGLATPEQAEKAMQTAFEQLNTPFGVEIMAPCYKQHAFDGANMLLFNPTTKENGGIFCQIQGWAILAEALLGHGDRAFQYFTESCPAAYNDRAELREAEPYVHTQFIEGHETPQPGRAHVHWLTGTASTVMVGCVEGILGLRPTPEGLVISPAIPASWDGFTMDKTFRGKRLHIVVDNTAHHESGVKQVLVNGTEVSGVLTDAVLTDGAEIKVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ28</accession>
    <name>R7IJ28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6A reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000224">
        <property type="protein sequence ID" value="CDE51491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51491">
        <property type="protein sequence ID" value="CDE51491"/>
        <property type="gene ID" value="BN770_00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="231" mass="26128" checksum="1FD55E063A386BE7" modified="2013-07-24" version="1">MERILIFGNTHESREAAQTMRRRGKQVIVCVTTEYARAQLPPGTMCHIGRFDDGQMLSYIRQTNPRKVIDATHPYATATQTRIRRSAEQLGIPCQRMKIENEQEAWRDVVQWVENPAEAMSVLSRLSEENILLAGDYRNLPHYASLLRKDHLFCRIVPTVEALDLAEKVGVPETHIVAAYGPYTRAFNSAVFDMLGIDVLVIRDVALDGGLAECVIPALERQIHVMMVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ89</accession>
    <name>R7IJ89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000216">
        <property type="protein sequence ID" value="CDE51363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51363">
        <property type="protein sequence ID" value="CDE51363"/>
        <property type="gene ID" value="BN770_00397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045690">
        <property type="entry name" value="DUF6055"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19527">
        <property type="entry name" value="DUF6055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448333" evidence="1">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="469" mass="53324" checksum="D507CB507D1E0BE5" modified="2013-07-24" version="1">MKLRRILALSLLLLSTLTPASLAETAHPGFYQPQENAAMDYDDSESRWSFARSVESEHFLLFWEAGFCENPLNAAPDMRVDTADLLEKAELFYAENVDRLHMADEPLPGGDKLQIYLLYTADWVATGAGYDNRIGALWISPATCQPAGSVIAHEIGHCFQYLTYCQALESGAPDDSRAGFRYGYAENAGNALWEIGAQWQSWQSYPEEMFTDYEMETWFQQYHRALENEYTRYQNYWWFYALTEQYGLDVYSRIWRESAYPEDAYQTFMRMYLANDLNAFYDALYRYASHAVTFDFAAAAPYSAAWQGRYDATLYDVGDGWQRIAYASCPEANGFSAIPLDHQGANRVTVSFRGLQPSSALAADDPGLYYIGDDATPENLTGHTRIYNAVDAAPGWRYGFVAYLTDGTRVYSDVCAEDEGAVSFDIPEETQYLYFVVLGAPESYQVHVWDNDEATDAQMPFEIRVEWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ99</accession>
    <name>R7IJ99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51700">
        <property type="protein sequence ID" value="CDE51700"/>
        <property type="gene ID" value="BN770_00575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016874">
        <property type="entry name" value="TcmP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028177">
        <property type="entry name" value="Polyketide_synth_Omtfrase_TcmP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="263" mass="29442" checksum="51C65AF6D2FF52B8" modified="2013-07-24" version="1">MRETSSKVTLSGVPETMLQTVYARAKETQNRGAVRDEKAVEIIRRLDYDFSLADKDSAMSNGVIARTIVLDKLVKTYLSAHPGAVAVNIACGLDTRCYRMQGYQHWYNLDLPETIAVREKLLPENGKISQIAMSAMDDWGGMILESGDALVIIEGLTMYLSEADVQRIFDVIARRFPRVTVLVEVMNPLVVRNFKEKSVEGSHAKFTWGVRDGQALAALLPGFQLVEEHSLTEGMAEFLPIYKVLDKIPLVRNISNRIVVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJG1</accession>
    <name>R7IJG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51914">
        <property type="protein sequence ID" value="CDE51914"/>
        <property type="gene ID" value="BN770_00694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="298"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="363" mass="38546" checksum="2CE4F21F82929BA1" modified="2013-07-24" version="1">MKSDLVKKLLRALVTALGIGLGSVLAFVIVQLNAMAGNPAMSVGALLALYAAFALLLGLGGYLIAPRTIDSITRLIALVERCMDKMTFEQQAGSISGLVGGFIIAALLSQLVMLMGASMFTVAMCAILFVVFGVLGVTLGIRRAADFKRMFQRFSPKGNKQVALSHRKIKTAKPKLLDETVLIDGRIAAVCRAGFLEGTLLIPRSVEKELQRLSASEEETCRIRGEKGRETLSQLEALGRVKRVDSAAGGELAQVLLADAKKHHMVIVTCDAAMSRAAEKAGVAALNLNDLACALRPMVQMGDLLDVRIVKAGREATQGVGYTPDGTMVVVEGGRDAVGQVLHVQVSSVLQTSAGRMIFAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJV2</accession>
    <name>R7IJV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51900">
        <property type="protein sequence ID" value="CDE51900"/>
        <property type="gene ID" value="BN770_00683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="355" mass="38466" checksum="9FAE66C815E1F85C" modified="2013-07-24" version="1">MSRRNENIFEEKSHLGRKIGVTLLVVLLLTFGAGAVANFAISNTVKTLRQTVTIPDLPNSLDQWSILLLTDLNGEYRGLNQASIGKAVGTRAVSCVIMTGNMIGENGDAAPALALLEQLPAGSKVLFLPGSGDPSPYATTAHASLSPYADWAQALIDAGVTMLDIPVSFTREKSTIWFVPEDLYTLNIPSARKAYQKQLDGLNALPTLTADQAALQRLAVYQLDRLDRIEAAMAEMTNKDMQVCVSGMPLTQEYITTAKQNADPKAVCAMNNVDLIVAGGYCGGQWRIPGMGALYVPELGWFPEDSQVQGINFFGGIWQYVSPGLGKGLIYPWWMSFRLFNSPAVTTITLSKNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJV7</accession>
    <name>R7IJV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HicB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51905">
        <property type="protein sequence ID" value="CDE51905"/>
        <property type="gene ID" value="BN770_00686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="120" mass="13277" checksum="79FE36EF600A27AC" modified="2013-07-24" version="1">MKTLEQYTALPYPLEIIPDSDEGGFVGSYPDLPGCLTCGETMEDVVRNAEDAKRAWLTAALEEGLVIHEPNLPTAYSGQFKLRIPKSLHRSLAEHSRSEGISMNQYCLYLLAKNDALYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJZ5</accession>
    <name>R7IJZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnp</name>
        <name evidence="9" type="ORF">BN770_00601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000243">
        <property type="protein sequence ID" value="CDE51761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51761">
        <property type="protein sequence ID" value="CDE51761"/>
        <property type="gene ID" value="BN770_00601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="622"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="719" mass="78875" checksum="0A8975CC54669B1F" modified="2013-07-24" version="1">MESKKYSMDLAGRELTLEFGKYCEQAAGSVWVHLGDTVVMVNATMAPTPRPGVDFFPLAVDVEEKQYSVGKIPGGFIKREGRPTEKATLTCRLIDRPLRPLFNKGMRNDVQVVVTVLSVEQDVPPEIPAMIGSSIALAVSEIPWNGPTGAVVVGRVDGQYVINPDEEQRAKSDMHVYLAGTKDAIMMVEAGANEVSETAMLDAIMFGHEYIKKLVEFQDKIVAEIGKEKVEVPLNVTGDDVKQAVREFAYDKCVWVFDTFNRQERQAREAQVKQETIEALAEQFPEREAEIADALYYLNKEVMRKKIIEQGIRPDGRGVTEIRPIWCEVGVLPRVHGSAVFTRGQTQALTVTTLGSTSEGQVLDGLSSEDFKRYIHHYNMPPYATGEAGRLKSPGRREIGHGALAERALLPVIPSEEEFPYAMRLVSEILSSNGSSSMASVCGSTLSLMDAGVPIHAPVAGVAMGLIKDVESGKVAVLTDIQGLEDFLGDMDFKVAGSMNGITAIQMDIKIAGIDRTILETALAQALKGRLFILEKMLSCIGEPRKELSKYAPKIVRFTINPEKIREVIGPGGKMINKIIAETGVKIDIEDDGRVFISTPDAEAADKARRIIEGIAKDIEVGEVYTGKVVRIMNFGAFVELLPGKDGMIHISKLANHRVEKVEDVVKIGDTLEVKVAEIDAQGRVNLVRNDITYDNTAAAAPRRAEGFRARPPRRDGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK55</accession>
    <name>R7IK55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding LysM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51836">
        <property type="protein sequence ID" value="CDE51836"/>
        <property type="gene ID" value="BN770_00645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024300">
        <property type="entry name" value="DUF3794"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12673">
        <property type="entry name" value="DUF3794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3794" evidence="1">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="509" mass="54149" checksum="473AA2379F309AC7" modified="2013-07-24" version="1">MDAQLRKETVTMEQVTAHGASQAVVEGEITLPGGLREETHVLHAGGMAVVDSAESGADRATLSGKVIFHVLYTQGAPNQVHVVEATADFIHQCDLSGAQPKGRVQAQARVEHVDASVQGGRLNMRAIVQLDARGASTQALEVLTGVNAPGGAEVTTQEIALRRTVASGQADTLLREEFELPEGLQVRETLCADAAAQISDITGGQGRIGVEGTVTISAVHASDLPGKPLVVTHHEAPFSQTLELSGESGDLLDARVTVRDVAVASQDAGDGGKTLRAEVLLGVQGTADTQEKLTVLRDAYTYQGAALTFSGRDVVIRTGQRRASAAESGKTTLLLPDGTPPVRGMLAAFATPIMTAQDSTGSRLNTEGMLEITLLYMTDENTAPVTVHQETPFRTSFAVSAAPDSILTLTADEVEATPITSDRVELRYVLRLTCDGVETQSAHLLTDAQEEAADEVDDGLYLCYCQNGEDWWKLAKEYRVPQEKLRRLNPDLPDALKAGTGVVVWKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKA1</accession>
    <name>R7IKA1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51896">
        <property type="protein sequence ID" value="CDE51896"/>
        <property type="gene ID" value="BN770_00679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023804">
        <property type="entry name" value="DUF3792_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12670">
        <property type="entry name" value="DUF3792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04086">
        <property type="entry name" value="TIGR04086_membr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="137" mass="14224" checksum="9C5F90E6CCEF2A8B" modified="2013-07-24" version="1">MTGTQTVRRTTTRARRGGSMQLLRGLGAAMLTTIIVVAVFALLMQWVKPTEDTVRIFNQLLKVVSVAIGTYIAVGRGQEGGLLRGALIGLLYMALGVAAYALLSGQGAPWTAYLADLAMGTATGGIIGAIVSNISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKJ3</accession>
    <name>R7IKJ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">BN770_00628</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51818">
        <property type="protein sequence ID" value="CDE51818"/>
        <property type="gene ID" value="BN770_00628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="22"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="29"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="341" mass="37778" checksum="C66AE8384B36D2C2" modified="2013-07-24" version="1">MSETNTAPKPEKKPIIFSGIQPSGTLTLGNYIGALRNFSKLQDDYDCIYSIVDMHAITVRQNPADLRRRCMELAAIYIASGIDPKKSLIYCQSHVSAHAELAWVLNCFTYMGEMSRMTQYKDKCAKHADNINVGLFDYPVLMAADILLYQTNLVPVGVDQRQHLEICRDIAMRFNGIYGDVFTIPEGYIPKVGAKIMSLQDPTKKMSKSDPEETFISLLDDADTIRRKIKRAVTDSDGEIRFDPENKPGVSNLLSIMSALGAGDVETLAAEMAGKGYGDLKARTTDCVIAALEPLQAEYKRLIADKTYLQGILDENAKTAAYLANKTLRKVQKKVGFAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IM70</accession>
    <name>R7IM70_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000239">
        <property type="protein sequence ID" value="CDE51712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51712">
        <property type="protein sequence ID" value="CDE51712"/>
        <property type="gene ID" value="BN770_00579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="371" mass="42148" checksum="C78C513031412445" modified="2013-07-24" version="1">MLLDQLDAQLTQKHQGKCAMLVYSAVTQCYQMLVLDAPMADAANAVPDVFTAEREPMTWELLASYSADPELPVRASFTTRVRVLRSVSRLLYQARRDGRSAAPEEDALRARLQEYQLMAKMQDESLENAARQVEEANRKAEEARTGRAEEEIKPIKEKLLAEFEEKLKAQEAQFAQAGRAKFQEAFGQQQKAVRERMEDEARWAAQLFDDAGMQYDKLRQDFARMQEEQNARMQQWQTAIYQADTRMLGQCYVGMATKLGDAVDQAIAKLMKPEMSAEEAKPLLELRAVMLSQLTRLEYAMKRLGLVVIRPQRGDTFQNDVHTLTTTSSETINVPEFAKIDQCITPGVLAERADLRFREVIVPAVVTLMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMB9</accession>
    <name>R7IMB9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000241">
        <property type="protein sequence ID" value="CDE51732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51732">
        <property type="protein sequence ID" value="CDE51732"/>
        <property type="gene ID" value="BN770_00590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33575" checksum="5B5DCEFF3782230F" modified="2013-07-24" version="1">MKTTLLIMAAGLGSRYGGNKQIDHIGPHGEILLEYSIYDAVAAGFDKVVFVIKRSMADTFRELIGDKIAKKVEVEYAYQEYDSLPDGFVPPEGRTKPYGTVHAVLVAKDLIHEPFAVINADDYYGKDAFATMAKSLKEMQGKTNVASMVAYRLKNTVSENGHVTRGVCARDDKNHLVKVQETYKIKPFPDGTIRDVNFREEGDILDPEALVSMNFWGLTPWFFGAAARDFAAFLRADNGDPMKKEFVLPTEIDALMHSDGLTVDVLSTDAVWFGVTYREDKPYVMGELKKLHDAGQYPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMF2</accession>
    <name>R7IMF2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51782">
        <property type="protein sequence ID" value="CDE51782"/>
        <property type="gene ID" value="BN770_00609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="166"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="284" mass="32348" checksum="02B8E15046320703" modified="2013-07-24" version="1">MPDKEWLYPNLRENGYTYSVLENLHYIPHVHGGLECVYVLDGELCATIDEKNYTLKKGDICLIFPQVRHSYRTPKHSNIFCFALLHDTMPDDLRSLFVDGYALPNPIYRAGSYSPLIPEMIDHMLMPEERKANRLVHTGRLLMLLGLLFDTRSPISAQKLAMSKEAEVLEYLHENFHDPITLTQAAEHLGLSQFQLSRICNHQIGMGFNAYLKSLRVTAAMRRLAFTNKGMQEIALGCGFESVRTFNRAFSEETGISPSEYRRAHQQCTALNLDVNPAPAKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I2R6</accession>
    <name>R7I2R6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HI0933 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46194">
        <property type="protein sequence ID" value="CDE46194"/>
        <property type="gene ID" value="BN770_00774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="414" mass="43736" checksum="CA2951D4F68AFA01" modified="2013-07-24" version="1">MGSVLVIGGGAAGLAAAIAAAECGDTVTVAEKMDRVGKKILATGNGRCNLMNTGAPRYPGNAAFAADVLSHCGAEAQKAFWEHLGLRLRQEEAGRVYPVSSQASSVLDALRLQLTALHVRVVTGVSITALHRENDGWTALSADGQQFRANRVIISGGGCAQPKLGSDGSALRLLTNLGCPATTFAPALTQIITDSTSIKGLSGIRVKAQVAVIDRKSVLHEEDGELLFADYGVSGVCVMQCARYAKDGRMLRVSLVKGMGFADAGDFRRELHHRRRNWAQRPMAELLTGLCVPRLSAALMRQADWRVTESSLCGQMTADMAERLTKTADAWLLPIRGVKGFESAQVASGGAAVADFDPATLQNRRLPGLYAAGEVLDVDGDCGGFNLMFAFGSGILAGLDGRNAPWTHENAQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I384</accession>
    <name>R7I384_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46344">
        <property type="protein sequence ID" value="CDE46344"/>
        <property type="gene ID" value="BN770_00828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="99" mass="10586" checksum="E50D9CEB83462C53" modified="2013-07-24" version="1">MFNNIGHKIQVLAKVLCWIGIICWVITGLALMAGGSSMTYRLNGEFVRANSGAGVVAGIMTIIVGVLVSWIGSFLLYGFGQLVEDTHAIRANTESKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3T3</accession>
    <name>R7I3T3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Csd1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46265">
        <property type="protein sequence ID" value="CDE46265"/>
        <property type="gene ID" value="BN770_00814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010144">
        <property type="entry name" value="CRISPR-assoc_prot_Csd1-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09709">
        <property type="entry name" value="Cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01863">
        <property type="entry name" value="cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="591" mass="65329" checksum="0A675B2DC6CBED84" modified="2013-07-24" version="1">MILQSLVRCYNSLAAQGKLERPGWSSVKVQWGLRLKENGELVSVELLGKPDEKGKPIPVQKPLPTPVKRTSGKATCFLCDNAKYLFGITNEPYDGTGKNPAKEAEACFRISAKKHHELLDGVSCPMAQAILRFFDTWQPEKAAQSPALQEHFDDLCKGGNLLFCLINELGTVTEAQNVPEIQAAWDASVSNSSERSTFGRCLVTGTQDTIAILHPSIKGVVGAQSSGASLVSFNAFAFESYGRSGSQGLNAPVGNHAAFAYGEALNYMLRVKDYHSLLGSATLVYWAETAQSAYSDCFAALLGTNEDMTQNTLDGIMKAIRLGQGLQWENVPLDSRTPFYILGLSPNASRLSVRFFLQGTFGDFAANLARHQERLNIIRPSYDTRETLSAYSLLKETANPNSRDKLPPSHLVGDLLRAILGDTPYPVSLLTQTELRIHAEHSVSRGKAAILKAWLLKNGSNPQYKEVIDVQLNEQTNYAPYVLGRLFAVLESLQQKANPGINATIMDRYFNAACATPSIVFPTLLKLAQSHLKKLDTGYFIYYDKQMTELCGRLTDSYPARLNLQDQGIFQLGYYHQKQKFFTKKEENSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7I405</accession>
    <name>R7I405_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">BN770_00846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46365">
        <property type="protein sequence ID" value="CDE46365"/>
        <property type="gene ID" value="BN770_00846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="94" mass="10054" checksum="51D1DB2140B573A5" modified="2013-07-24" version="1">MTVKPLGDRVVIKNVEAEETTKSGLILTSAAKEKPQMAVVLAVGPGGNVDGKEIKMQVTEGQKVIYSKYAGTEVKIDGEELIIVRQSDILAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I471</accession>
    <name>R7I471_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC-type DNA-binding domain-containing proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46246">
        <property type="protein sequence ID" value="CDE46246"/>
        <property type="gene ID" value="BN770_00801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="628"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="736" mass="83883" checksum="0B67121F45154801" modified="2013-07-24" version="1">MTRKKPWQTLRARLGRASGIALSYTMFLFVCLALLVIIGFTYDSRVRDSYWQQQRSHLTRVSSGMESQLQLMSDYSLQLRTDTTLLRLSNMHDETDANYVLAAYRMMQSLTIRQYGLISLPVIRSTLYLKESNHILTSSESVPAELYYRHTRSFRASEYENWLETMESATVKPTFVDYGQFSGRSGELAVLIDISGAQLPSMPVVVAFELDGSALREYLLPENIADAAVYVLSADGTPLFSVGNAVALSPLTFDANQTAFQGDYRILRRVSPSGRQYLLLLPNSLANQATGQFLRIYLLIFLVALVLGALVIIQLIRRAMKPIRQLTTQLDEAEDANAQLQREIDTQRPVINASYLRKLLSGHVASQDEFQYMMDSLGLTGDVHHYVLFCIANRQDSEVADPNAEYDTITAAMERHLSGAYPLYYYATLFGSFVVLVTYANSDADSFSTLQQHVVQLHDELADAGLWFYAGVGSRCTQPSRLWESYEQARAASRYTAKHHIFLPYDFIRKDTQSWYYPIEISAKLLHFITTGNKDQTTDMFALIHRENVEERSLPLPLLNMLLSDLKNTLFKARFQVLPSQSEEMAAKLKKLDERLYSPAPTFAQLEDDALCLCEFFVKVSSPSTPIPDVERYLQENYTDPSLCLSKVGDRFNISDTYLSHMFKEKTGQNFSVYLERLRMNEAARRLTSGDCNLTVLYADLGYTNPTSFRRAFKKYYGMTPSEMRDQPRRQEEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I475</accession>
    <name>R7I475_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-N-acetylgalactosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46251">
        <property type="protein sequence ID" value="CDE46251"/>
        <property type="gene ID" value="BN770_00803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="328" mass="35960" checksum="1A6DE2E9E7696B9B" modified="2013-07-24" version="1">MNIGILGAGNIAGSMARTICGMAAQGRPVTLYAVASRSQEKADAFAKAYGIPRAYGSYAAMLSDPLVELVYIATPHSHHAEQIRQCVAAGKPVLCEKSFTANAKQAEDVLREAEAAGVYVAEAIWTRYMPARGMIADIIASGEIGEPRFLSANLAYDVEHKERISQPELAGGALLDVGVYPLNFASMVFGNDIVRVESSVQKLGTGVDRTENITYFYRDGKMAQLMASVAFNSDRRGIVYGTKGFLTVDNVNNPHEIALYDKNQRETPREVRPVPAQITGYEYEVEACLRDIAAGQLEPAEMPHAETLEIMRQMDTLRAAWQIRYPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4I8</accession>
    <name>R7I4I8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative manganese efflux pump MntP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mntP</name>
        <name evidence="9" type="ORF">BN770_00073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably functions as a manganese efflux pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MntP (TC 9.B.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46764">
        <property type="protein sequence ID" value="CDE46764"/>
        <property type="gene ID" value="BN770_00073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01521">
        <property type="entry name" value="MntP_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022929">
        <property type="entry name" value="Put_MntP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="190" mass="20384" checksum="4C82A5B6829B748C" modified="2013-07-24" version="1">MSDMSIWEILLLGVGLSMDAFAVSICKGLSVKKVKWQHLLCVGAYFGIFQALMPTLGYFLGTTFSNLIDQFDHWVAFILLAIIGVNMVREALSKDEDETNDDFGFKTMLLLAIATSIDALAVGVTFALEGTDIALAACLIGLTTFTLSPIGLLVGNRFGLRYKSKAELVGGLVLIGIGLKILLEGLGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4P5</accession>
    <name>R7I4P5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46834">
        <property type="protein sequence ID" value="CDE46834"/>
        <property type="gene ID" value="BN770_01042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="415" mass="46216" checksum="93304B422CCE4084" modified="2013-07-24" version="1">MTDEQMKKLLEEDTGEVPERFHQAMLAAFGQMEDEPFDGTELPISVEAAEKPRRPRHVPRQGGRFRRMLLVMLITLGLLGGLAVATTANPRLLEVFWGKDFEPSAQASAYIAHDLAEVETNGYRVRVEEAVYDGMTLYVRYSIRDMSCDHLLGETNVDTGRRMLNEQEITAFDHAPVGWWTDNLWLNGQNVDMPGLSGGETWAGDENGEIVVSEMYRLDQVGVFLSGDVQIDLPIGEKQHYDYEMWQSMLKEDGTFRKPDAGLVSFTLNCDAPVTHYADGERVVLPDGTAAWVESADDTPVKLYVTVRFEISDAQREAFRAENGEGYVFPDGTVMPFDDVDMVGSWVYGLTLVDADGKPLRASLGYGEGNWGVGSGVADYVFSHEDAYPEQVYLAPQTGEDSADMAWAIPLPVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4W1</accession>
    <name>R7I4W1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">BN770_00807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46258">
        <property type="protein sequence ID" value="CDE46258"/>
        <property type="gene ID" value="BN770_00807"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="250" mass="26288" checksum="9106F1DC9C7CD871" modified="2013-07-24" version="1">MRKAIIAGNWKMNKTPAEAAALVNDLKPLVKDASCDVVVCVPAVDIAAVKAAAEGSNIHVGAENVHWAASGAYTGELSAEMLVAAGVEYVIIGHSERRQYFGETDQTVNKRVLAAVAAGLKVILCVGEMKDVREAGATDGLVDYQTIMALNGLTAEQVADVVIAYEPVWAIGTGLTATDEQANETIGVIRKAVARKYGQECADKVRIQYGGSMNPKNVKGLMAQPEIDGGLIGGASLKAPDFSLVVNYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I529</accession>
    <name>R7I529_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46348">
        <property type="protein sequence ID" value="CDE46348"/>
        <property type="gene ID" value="BN770_00830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="42" mass="4588" checksum="CB13B28946AFEF78" modified="2013-07-24" version="1">MESGKFAKIMGIILAILLILGALADVCSDSYSFGYSLGYNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I543</accession>
    <name>R7I543_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Two component transcriptional regulator AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46368">
        <property type="protein sequence ID" value="CDE46368"/>
        <property type="gene ID" value="BN770_00849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="266" mass="29545" checksum="F329FBE487F9C16D" modified="2013-07-24" version="1">MYKLLLATNDPAVVEAFSAVKWEELGFKQPRVVSTAEEALSSLRVNHADAVAIGLPKEQDDLLVGQLLEKNPMLPIMAVSTKPGVIESYAVELRRLLGRINADVSNDAFSTADLLKECRHEFFRALMDGKATSEEDVLRHLRLIRSKMDPTKPCVVAELEIPADNDFLRGRWQYGSDRLEVALRNIFGVEAHGLRILACVLPGDRIVLLGCPMLFHEGPDEDASITGILSDHIRDSIEHVDEYMGIDLRIASIRVLPCLTALAHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5A0</accession>
    <name>R7I5A0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46790">
        <property type="protein sequence ID" value="CDE46790"/>
        <property type="gene ID" value="BN770_01019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="263" mass="29357" checksum="9B0ECB8C78B3F7BE" modified="2013-07-24" version="1">MKYAFHALRMQWRCATQYRASFWMQTLAQLVMSGSELMAVLVLLGRFTSVGQWSGSEIMFFFGMMQMTFAITECVGRGLTAFSRVVQGGEFDQILLRPRNLLLQVLCSSTDPRRLSTAVLGIVLMWLSVTQLGIPWTLGSTVLLLISVAGTVLMLLGLFLVEATLCFLSVQSIEAVNILTYGGRTACEYPVDIYPRPIRLLFMYVAPFGLCMHVPVSALLHHPMVDWPAWTAYLAPLAGAMFFLLMALVWRKVGVKRYCSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5D9</accession>
    <name>R7I5D9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47094">
        <property type="protein sequence ID" value="CDE47094"/>
        <property type="gene ID" value="BN770_01149"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="244"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="376" mass="41109" checksum="50AF5FCB7849E8E6" modified="2013-07-24" version="1">MFKEGELHMQQYPVRTIDLEALRENVRLLRSTLPEKTKLMAVVKADAYGHGIAKVARAALEAGASALAVARTDEGAALRQAGVTAPVLVLGASSDEEIAEGVRNELTLTVCTPEMVDTLESCAKESGLTGLMHLKIDTGMGRIGVRTEEEIRAILARLQVSPHVRLTGAFTHFADADGSDMAYTRMQFERFQQLLTLLPDGIVRHCANSAAIHRCPEAALDMVRAGISMYGHPPVETDLPLRPVMTWRTQVTFVKTVQPGDKISYGCTFTAEKPMRLATVACGYGDGYHRNASSRAQVILHGQRARVVGRICMDQMMVDVTDIPNVKAGDEVTLMGSDGVETITPDELGSWSDTIGYEVLLAATERVRRVWLHEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Y0</accession>
    <name>R7I5Y0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ORF">BN770_00974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46658">
        <property type="protein sequence ID" value="CDE46658"/>
        <property type="gene ID" value="BN770_00974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="85" mass="10172" checksum="64134C930BFF1881" modified="2013-07-24" version="1">MSEERSERRPRPRGGRRPRRKVCSFCVDKIEYIDYKDINRLRRFVNERGKILPRRMSGNCAKHQRQLSEAIKRARAIALLPYTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I606</accession>
    <name>R7I606_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47264">
        <property type="protein sequence ID" value="CDE47264"/>
        <property type="gene ID" value="BN770_01189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435509" evidence="1">
        <location>
            <begin position="24"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="277" mass="31057" checksum="212E8CE95B5BE2A6" modified="2013-07-24" version="1">MKKIISVLLVLCCLTLSIAPALATEKSDLTDGEVLALHFINEFYPADKGDGEEYLVTFDTENKHFIIHGHYPLLESLIIDRPEDYQAMAEQLEKLFTSVNNLVEDALEAPEEYYMTLSLGTANYSLEYPVCEYLCISTKGGTVHRVNDEFVSTNEIKFYVANENADASAVQSILDLFATKDVSVLGITCMASQNPDNNGFFIALSGAYCDKFAAGYKGKDADWVEIPDRYIIDCRELATKNNLKQISLTFLDEQGNAFGAMQFSDSYWRGYYYAIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6J1</accession>
    <name>R7I6J1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46863">
        <property type="protein sequence ID" value="CDE46863"/>
        <property type="gene ID" value="BN770_01062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="133"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="307"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="404"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="768"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="850" mass="94152" checksum="72ADD80443341357" modified="2013-07-24" version="1">MFQIQSFTCEGLREHLVTDCAAPTFAYFVSSDRAGASVQSAELTVNGWTIRNPDQCGTRYAGQPLKPFTTYTATLTVTSDSGETDTARLTFETGRMDTPWQGKWITDGAYVFKEKKVSPVPMVFRKALPLRGEIAQAKLYATAMGIYELNIDGQKVGERYFAPGFTSYAHQLMYQTYDVTDMLRSGSCITATLAGGWAVGSFVFTRVNRVTADRQALLAELRITYRDGSTEVIGTDESWQVTEDGPVRMADFYDGETYDATISLDKAAWRSAVQERLRVKPKLMADYGADVKEHETFAPVSCKKLGNALIYDFGQNFAGVVRLTVTGKRGQKITIRHSEVLNPDGTLNTAFLRTAKATATYICKEGRQTWSPRLTYMGFRYISVEGVREEDVQVTGVMLYSDIQQTGSFRCSNEMLNRLQENIVRSAKSNFMDIPTDCPQRDERMGWTGDIAVFAPTAVFNFDMNRFLDKWLLDVQAEQLPTGGLPNTVPVQGYGFPATMPKMAVAWWGDACVLVPWAQYMARGDVGVLRRMYPTMKKYVNACRFWCGFGFGKHRYLWEMPGTLGFGDWVAPDVPQMSQWQGRIKWTGTASLCNTSALLAKIADILGETQDAKHYRALSEKTADAYCSILTDGNGKLLEEFQTAYVLPIYLNMFPTQQIREKAAANLAALAKRNDWCIGTGFPGTPYILFALCDNGQVDAAYHMLLNTKCPSWLYEVKAGATTIWERWDGLDENGVCPIGDDGTDKMISYNHYASGAVGDFLYRRIAGIEPTESGYKAFRVKPILGGGLTSAAAKVRTPYGDASVQWKTAADTFTVTVCVPVGTRCKLTLPDGTSQILASGTHTATCSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6M3</accession>
    <name>R7I6M3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46187">
        <property type="protein sequence ID" value="CDE46187"/>
        <property type="gene ID" value="BN770_00768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="87"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="334" mass="36369" checksum="2BF7D14F25D9679B" modified="2013-07-24" version="1">MIVILKHEARQEQIDRLKQFLLGMGLRIDESKGENSTILGLVGDTTRVDADLISSLDAVEAVRRVQEPYKKANRKFHPQDTMVDCGGVTIGHGLFQIIAGPCSVESEEQMVTVAKAVKAAGATLLRGGAFKPRTSPYAFQGLHEDGLKLLLKAKEATGLPVVTEIMDASHLPLFDDVDVIQVGARNMQNFELLKVLGKTHKPILLKRGLANTIQEWLMSAEYIMAGGNDQVILCERGIRTYETATRNTLDLSCIPVLREKTHLPILVDPSHATGVARLVKPMAMAATAAGADGLMIEVHNDPKHALCDGAQSLTPDEFADVVRRVKGIRAVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I723</accession>
    <name>R7I723_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000056">
        <property type="protein sequence ID" value="CDE47659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47659">
        <property type="protein sequence ID" value="CDE47659"/>
        <property type="gene ID" value="BN770_01326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="34" mass="3882" checksum="20BF4D0A82621ECB" modified="2013-07-24" version="1">MNVVVRETGPPCASKLPVKIKHIEILRRIIYYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7G3</accession>
    <name>R7I7G3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47575">
        <property type="protein sequence ID" value="CDE47575"/>
        <property type="gene ID" value="BN770_01289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="72"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="548" mass="61623" checksum="FE00173C4F7B8479" modified="2013-07-24" version="1">MLFPLRVIRRIHREGFRCIPEAIRFRIALHRQRPFLQTETALRQAEEDGYQAFIRRHEAPLSAPFTPTMRLSFLIPTYNTPPELLRALADSLLHQSCGAWEACFYDGASTRVDTRELLQALTQEDNRFRVTFGAENRGIAGNTNAALTMATGEFVALCDHDDLLAPDAVRCILEAAQDGADFVYTDEDKVSADGTHFFEPHLKPDFAPDSLRSGNYICHITAASRALMNAVGGLRPGFDGSQDHDLALRLSENAAKITHIPRILYHWRMLDTSFSHQKAQTCADAAARAVADQLRRLHMDADVTVEELRVRIRWKTRQMRSVCVLWGEGDAPKLPMPCIRVRDLSAVNDLVRRTDCDAVLFLRAGLRPLDTDWVSELMQYAQRADVGCVGSALLDDRDCFRHAGYAVDVPGGAVSHQAGQWRYGRPYMLTDRIVRNVTGVSSALLMIRRDVFLSVGGFSPYQSDLRGADLGLKCQQIGLLNVYTPYARMAMDMRLSLLPPCLTQGAPKGDLRRFRQTWGAHPPERYYSPLFRPDGSMFIDLDRQEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7H0</accession>
    <name>R7I7H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47580">
        <property type="protein sequence ID" value="CDE47580"/>
        <property type="gene ID" value="BN770_01293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17869" checksum="3EAA6A0577C4388F" modified="2013-07-24" version="1">MKALSTRLFALNEAWKENANIYRQMAKQMNLTDMAMWALYTLRVEPGEMTQSRMCEFLHEPKQTINSALKKMEADGLITLQSGSNRRTKTIHLTAAGEALARETADRVAETEQQALAQFSEEEADQLFSLLRRLNALMIDIFPQTVRNQEEESQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7P2</accession>
    <name>R7I7P2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="9">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisS</name>
        <name evidence="11" type="ORF">BN770_01197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47278">
        <property type="protein sequence ID" value="CDE47278"/>
        <property type="gene ID" value="BN770_01197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="423" mass="47005" checksum="E269AAD315B13330" modified="2013-07-24" version="1">MLTQAPRGTKDVLPADSYRWQYVESKMRQAAAEAGFREVRTPVFEHTELFLRGVGDTTDIVQKEMYTFKDKGDRSITLKPEGTSGAARCLLENNLYADTLPCKMYYLNAPIFRYEAPQSGRLREHHQFGLECFGARDASADAELILLAYRLLSGLGVKNLSVNINSIGCPNCRPKYHATLKSFLSGRIGEMCSTCQTRFDRNPLRVLDCKEKHCQELVADAPSMLDLLCDDCKAHFAQLQSYLDAAHIPYQIDPRIVRGLDYYTKTVFELITKTENGNLTVCGGGRYDNLVEQLGGPSLHAVGFGMGIERVLMLLDSEGVVIPKPTLYDVFVTYMGAHQVEAFSLVQKLRDAGFKADMDHTGRSLKAQFKYANKMGATLTATLGDEEIASGVVKVKNMATKEEQTIALDNIADGIRNMFASSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7S7</accession>
    <name>R7I7S7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">BN770_01427</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47914">
        <property type="protein sequence ID" value="CDE47914"/>
        <property type="gene ID" value="BN770_01427"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="119"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="238"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDE47914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="388" mass="41930" checksum="3114CD66BFFCD9C5" modified="2013-07-24" version="1">MRKLFTSESVTEGHPDKLCDQVSDAVLDALLAQDPMSRVACETCATTGMVMVMGEITTTAKVDIPAIVRDVVLDIGYNDSSLCFDGNTCAVLTSIHAQSPDIAMGVDDALETRTQGANEIGAGDQGMMFGFACDETPEYMPTAIAFAHRLTRRLTEVRKNGTLPWLRPDGKAQVTIAYEDGQPVAVDTIVISTQHNPEIAHADIYAAMMEHVIRPVIPAEMLTADTRYLINPTGRFVIGGPAGDSGLTGRKIIVDTYGGYAPHGGGAFSGKDPTKVDRSAAYAARHIAKNIVAAGLAKRCEIQLAYAIGVARPVSLFIDTMGTGVVSDDQLAAAVDKLFDLRPNAIIQRLNLRRPIYRANCNYGHFGKADMPWEQLDYVNALRREILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7U8</accession>
    <name>R7I7U8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47576">
        <property type="protein sequence ID" value="CDE47576"/>
        <property type="gene ID" value="BN770_01290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="210"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="466" mass="51891" checksum="3FB43D9429199D07" modified="2013-07-24" version="1">MTKCKPPIFGDSAVLKKGLWVTLVIALVLALYGALFAPTWQTRAFTIDAAAQTHLHPLTDGETFTLPLPDGGIREISLPVTALSSESGGTATLILTRQGLPIFTQTALLTASTIRENLTFSFEPMDADKLVLTFSGNTLPALGMSSGNQLCIRLSGTRPSCAMLYYGIFAAVLVLFCVWESLFTARCAATGRQNHLLRLQADVRRYGFLIEQLVRRNFNTKYRQSILGVLWSFLNPLLTMLVQYLVFSTLFRSGIDHFPVXTLFRSAIDHFPVYLISGIIVFSFFTECVTLGMDAIVMNASLITKVAIPKLIFPFSRALSSLINFLISLLPLLLLMLLTGVRVSPALLLLPLMIALLFLFALGVTLVMATLNVFFRDTRFLWSVISLLWTYATPIFYPDTIWPEGLRGIFHLNPMYQLIDFLRQIVIAGIPPTPERLLACAAGAFGMLMIGLLIFRRYEKKFVFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7V1</accession>
    <name>R7I7V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47348">
        <property type="protein sequence ID" value="CDE47348"/>
        <property type="gene ID" value="BN770_01219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="677" mass="74207" checksum="752DD2C86FDBD700" modified="2013-07-24" version="1">MSIDNQLLFCYLEEDNIQQAYFRVRPLLTPDADIRQEAMNQFPVEGCLRIVPDRNEQHTFKSRMRDLGHYCLVDLANLPAEATKIRTNKNFRPDKGEPNQFILYSDTVHELPAHSFYEVISAPADDAAVVAETAITPLFYLRADNVLYGPVCKNDPEKPQKSSGMAGMLFTLPCPDGVERTILCLKDAPTAVRPAPIQRQMRPKPVRFDRPLDAAAVPAAAPSAAASPSDPIAPAGPVVPADPATPAAPVAPEAPAAEKPAEKADAADESLPIGETLNILDETKDFEETLQSLNTGVSDSANLLHQQQTRPVKMPPSMMKTGPLTGTPLVRTPLRTSPQPSKNRVQETVSSQWYVGKYEPPAQNLPNGTSMRPIDNPVADAVNAFRAAWRMPEAREQLMDFMLSLDGLRSKLEPRICKDRNITALQRVLRDRLQDLEAERLTALCQLDKARRDMDGFKQEIIAGMANRLQKETGKLESDRDACEAQLASLKTELNSLTVQRDSLLKHIDTLQNDALPATISKLLGDLQLNIPLTGQPLRMSPVSGQQATLDELLARLTAVCGKCGLTLTKNQGIALLLLLAMSDRIGIVSSTPAPAATLIRNIAAAMGWERSFAHQISAEQRPMVALRPVDATPVLLLTSLPNYAPICWRWSGSAFVGMSRFVMRNSPPAGLYTHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I802</accession>
    <name>R7I802_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NLP/P60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000055">
        <property type="protein sequence ID" value="CDE47631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47631">
        <property type="protein sequence ID" value="CDE47631"/>
        <property type="gene ID" value="BN770_01318"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435578" evidence="4">
        <location>
            <begin position="25"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="5">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="5">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="311"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="5">
        <location>
            <begin position="494"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="580" mass="63108" checksum="FDE4BA24A5425CB7" modified="2013-07-24" version="1">MPLWKRTLAALLLAVMMILPFASAEDAGEAVPDDSVEWTEGAANITRDLTLNDEGDDVSALQTALTDLCYYSGDVTGRYGEATKTAVEDFQRDFALAVTGMADKATQEAIYAADYRPLRLGCVGEDVRQAQIRLMALGYYTGKISGRYLPATQEAIRLFQTANALPITGEADVQTLERLFSGDAISRDSSAAATPTPSPTPGMHLSDETTTPTPAPTVAFVKKLQYNKSKGEEVKLVQTRLTELGYYSGNISGNFLGHTRNAVKAFQQQNALSVDGIVGENTWNALFNDPDVRAATDDPKPTPEPTPVPFAITVDVNNQVTTVYGRDENGDYTVVVRQMLCSTGTRKNPSDIGTFTLNGRTARWCYFPEWGSHAQYWTRINSSIAFHSVIYNTVNTMDLSVKSYKNLGKRASHGCIRLTVADAKWIYNNCGAGTVVTIRDDMPADPELRAALKLPSLNTKNMLPYVTPQPTAEPDYRAGTMPPQPFRTLKVNSSGEDVYWMQRKLTDLGYYSGKCSGTFLAGTQNAVKAFQKANSLSATGTADVKTLKLLYAEELSATPTPEVTADDRTPEPLPTPAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I892</accession>
    <name>R7I892_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47810">
        <property type="protein sequence ID" value="CDE47810"/>
        <property type="gene ID" value="BN770_01371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010719">
        <property type="entry name" value="rRNA_methylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35276">
        <property type="entry name" value="PTHR35276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06962">
        <property type="entry name" value="rRNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="188" mass="20510" checksum="965455F900DE0642" modified="2013-07-24" version="1">MSYELRSARWIAADVLRQVVQPGDTVVDATLGNGHDTLILCELVGETGRVIGFDIQPDAVERTRERLADAGMLSRCTLYAEGHEHLSERVTVPIRTATFNLGWLPGGDKRITTHWETTRAAISAALSLLVKGGVCTICAYPGHAAGDEERAALMAYLSALRPQEYNVLHHRFLNAGAGAPECFVVQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I897</accession>
    <name>R7I897_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6273 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47815">
        <property type="protein sequence ID" value="CDE47815"/>
        <property type="gene ID" value="BN770_01376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046240">
        <property type="entry name" value="DUF6273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19789">
        <property type="entry name" value="DUF6273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6273" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="542" mass="60023" checksum="E99A8ECCC4BF3550" modified="2013-07-24" version="1">MCRAAIAPVTLADTAADGNPEWQNTDAEPAETHVFLLSYAQVMQYLPEQEQRKVSGTEYARSRGAKFLGFTTIGIGETDWWLRSPGKESYDACFLDVRGAVGTKCVTEKLGVRPALWMDLSADRNAFPYEQQVQAKQFAEQGDYAEATALLDTLGDYAGSAALAKEYRYQQAQAEAASGNYDAAIALYTELAGYADSDALCRASRYEKAVAAQEAGDYAGAMALFADAGQYADSMARLRECCKQQGISIYYFSEDAVNAGVDTGYAKQDTISGDDKHFGWRLGRFFLTGFTRVTADENQQPVFIKTLGDSVTLWFDLEQDIDALNGNAQLSLAADANGYDQQFGIPKTNFGRGTLIVRHTDYQNAKNEPVVYTDYLLAKGTTGANTRIVLHEEGDYEVALDYEVQDSELTHITSKFGNYRIFLRFSIRNGNCMVYPFDLLTGAELQNTSVAEAGFSLDLARSRYLDINVRRAVLVETANGVIEDERFNRPAKDGDRYTQEGIYTISVSNRYTGESTTKTIFVGSQELLETYVRNGFSLERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8F6</accession>
    <name>R7I8F6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000082">
        <property type="protein sequence ID" value="CDE48164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48164">
        <property type="protein sequence ID" value="CDE48164"/>
        <property type="gene ID" value="BN770_01567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="456" mass="50958" checksum="A7265FE1F472E251" modified="2013-07-24" version="1">MLDQRLATRVENFVSRLKRESVCMHGFILDVRGEVKATAYYPPFEEGKAHRMYSVSKSMTALAIGLLLDEGKISLDDRIADCFRDFLPEKPDARLMRLKIRDMLRMATCYRATVYRETDDDWTKPFFTAASTHEPGTVFHYDTGCSQVLAALVARLTGQQVMDYLTERVFTPLGANDEKHWLRDPAGTCQGGTGLCMSLRDLHKVTRLVMDGGRGILPEWFCREMTKKHIDNCLCTNEEERYGYGWQVWMTRAGWAMYGLGGQLAVVCPEKDVCLCTIADTRLDPIGVQRIYNAFFDEIYPYCGMEDMSPVRLSPEIQPLGNNPACALDASPVYHFAAPNLLGLACVELRGNTLIWENARGRHPLQFGLGENLASEFPGWPGRTMLSSGGWVSADENGNLLRVRCQIIDDAPCGVDMLLHFTGTCLTVQARKSSDPATNAYEGVATGYVEGYADES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8G2</accession>
    <name>R7I8G2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sensor histidine kinase VirS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47766">
        <property type="protein sequence ID" value="CDE47766"/>
        <property type="gene ID" value="BN770_01348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="3">
        <location>
            <begin position="342"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="457" mass="52080" checksum="6D6321FB8C40AA81" modified="2013-07-24" version="1">MIAFLARWLGERYSYQMGLSVIAFLEALSGVAVFIFPLKHKPQYVVRAAAGLALMAAIMIIRAILRTHLETLLWSRFISNMLEYLSMLPLLFLAHEGTWCERLKAWCAGCAAVQIAGSLYALVLSFTGADDTQTMALFPQITNADVTLLIWFVFHLAVCYLLRLLFIHPSVQYHEDRKSQIQTTWLCILFLLASVLINAVMSEYRADSRPLYEMLRCCLVFMCISVLALHHDIVLFSQNRAEIEVMDQVLAENRRQYETMKANIDLVNLRCHDLRHQLDKLQSRLTESEISALREAIDLYDSNVKTGNEVLDVVLYSTMLKCMDNGISFTSMADGECLSFMRTRHIYALFSNALDNAVEAVMRVSNPEKRVISLHVRRLSGAVEIAVMNYYEGEIKFKNDLPQTRKPDGRRHGFGTSSMQYIVSQYGGTMKISAKDSVYLLEIRLNIPEKAEKTKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8X9</accession>
    <name>R7I8X9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48319">
        <property type="protein sequence ID" value="CDE48319"/>
        <property type="gene ID" value="BN770_01644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE48319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="225" mass="25838" checksum="649E9CCE7AE99AAF" modified="2013-07-24" version="1">MTLLIVDDEARIRDLIRKYAAFEGYNVEEASNGMEAIEKCRQKNYDLIIMDVMMPELDGFSACREIRRKSQVPVIMLSARGEEYDRIHGFELGIDDYVVKPFSPRELMMRVSAVLKRTAANVPAASDGERVTIGDMVVDFAARQVTIKGEKLNLSPKEYDLLFYMVRNRGIALTREKLISDVWGYDFFGDDRTLDTHIKLLRKSLGEYADKITTLRGVGYRFEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I933</accession>
    <name>R7I933_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48384">
        <property type="protein sequence ID" value="CDE48384"/>
        <property type="gene ID" value="BN770_01675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="33166" checksum="BE280C249DD49CA5" modified="2013-07-24" version="1">MEKMTINQLPSRTWNRLGVNEASIDWDESATVVLPEESAEKADMLIASDAAYARKRVTIQAEKGAKKLLFQTIRTAGKLYVQTELTAEDGAEMELTQLVAPGENALVYDEVIGHCHGSGRIVLRQVTLGHGDVYAQTGIGLDGENASFAANIGYLARKNQTLDMNLVVNHWGKKTKCEINASGALNDAAKKIFRGTIDFKRGSSGSVGSEQETVLMLGEDAVNKTVPVILCAEENVEGTHGATIGEMDDDTRFYFGSRGIDRETAEKLLSRAAIARMAQQVKSETARAAILNELDGEMDENDGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9I5</accession>
    <name>R7I9I5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47953">
        <property type="protein sequence ID" value="CDE47953"/>
        <property type="gene ID" value="BN770_01453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="145" mass="15898" checksum="F02462DA3DB6E38E" modified="2013-07-24" version="1">MKKYVQCPRCELNYITTPGDKYCKVCMREMKGEGGQDDVEMCSVCNENPALPGRDICLFCLKEMNAQAAESVGAASDDSGDSDGEQVTPRSLTDMDDVGSMDEIQMLPEETDGEYTKMAGEMTSLEGMQEDEANEDDDADADDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA27</accession>
    <name>R7IA27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Holin phage phi LC3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48326">
        <property type="protein sequence ID" value="CDE48326"/>
        <property type="gene ID" value="BN770_01651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006485">
        <property type="entry name" value="Phage_holin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04531">
        <property type="entry name" value="Phage_holin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01598">
        <property type="entry name" value="holin_phiLC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="79" mass="8733" checksum="714DE38805D907EC" modified="2013-07-24" version="1">MKINWSLRFHNKVWLTTLLAVVCTFVFNLLDLFGIETTVAQEQVMQLGAALLSLLSTLGVVIDPTTPGVSDSQTVIERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAA2</accession>
    <name>R7IAA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000105">
        <property type="protein sequence ID" value="CDE48416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48416">
        <property type="protein sequence ID" value="CDE48416"/>
        <property type="gene ID" value="BN770_01692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436315" evidence="1">
        <location>
            <begin position="27"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="520" mass="59697" checksum="0EEF91D800F0C06E" modified="2013-07-24" version="1">MKRFLSLVLSLAMILPIMLAATPALAEENPYAEHLTFKVFTIDGSDDMFNWPLVKQAMEKFNFDFEIQLVAWDSWDESTRTLAYTQSLPEVIAWYNLNKDEYLEWVEEGVFKALPDDMSAYPNLEKLINSYTCFDQFRVDGKLYTFPKIKNSNPVNLYTTYMFAYRRDWAKAMGYDWAPVQTLTYDEFVAYLRDVKEKDPGHMGDKLVPLDLDNGGKHWAMLAQLWNQRIGSFDIVDGQYRWSAEDPSSLEAIKQIKTLYDDGLLAMDSYNDSNNAGRERFLAGRSAVLYGNLGATILQTTARTLATNVEGFTEKDLGIICLEAPDGTFHVSQIDEWWAAFAFSANCRDEVMDRWLAVGNWLLEQEQIETYAYGVKGEDWDYDADGNVVLNYTDADIAATGSKYYIVQERAFQKYFVLEGLDVYLPGNPAYSSYIINDLFTTNMKTWESNATFAPTDYNLTNTKNEAYYSFRSAVINNIRDIIIQAVISDDPETVWNDFVNEHREEGDKLAAELTEEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAI9</accession>
    <name>R7IAI9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-oxoacid_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48605">
        <property type="protein sequence ID" value="CDE48605"/>
        <property type="gene ID" value="BN770_01746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="1">
        <location>
            <begin position="189"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="310" mass="34964" checksum="A7F9FBD56FE62A3E" modified="2013-07-24" version="1">MFGFRPDGRRVSSIDPIVGITPYLMPMRCDAQVFLQHRVDYELLTRYIAAQAAKGEKITFMQIITAAFVRTVSQHPEINRFILNKQFFARNMCAVSFTMLKNPQNAEMGETAVKVKYDLTDTIYDVRDRMEKVINANRGEDKKNFADKLAKAVLVVPGLATGIVALVRLLDRYGLCPGALLDELPFHTSMYITNNASIGLHHVNHHIYNFGSVTLFFGMGTVEKVAVVEKGEARMKRFLPIGITADERVCSGAHYAAFFGTMSYLLNHPEELEKPPESVRFDEKCEYHVPKVGEQPAKKQKKQQKATVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAJ3</accession>
    <name>R7IAJ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium uptake protein TrkA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48288">
        <property type="protein sequence ID" value="CDE48288"/>
        <property type="gene ID" value="BN770_01621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="91"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="170" mass="18160" checksum="F9AE1871E46ED71B" modified="2013-07-24" version="1">MTQAVQANAVDEDALAELGVQNFDAAIVAIGTDIRASILATVLLKEAGVPKVLAKAVDDLHARVLYKVGADRVIFPERDMGQRVARSLVAPNILDLMALSDDDQIAELTLPTDWADKTIVELNIRRNFGVSVLGIHRGGKFLTSPGAETMLMAGDLLLVMGKKEAISAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAK7</accession>
    <name>R7IAK7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisC</name>
        <name evidence="6" type="ORF">BN770_01631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000094">
        <property type="protein sequence ID" value="CDE48303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48303">
        <property type="protein sequence ID" value="CDE48303"/>
        <property type="gene ID" value="BN770_01631"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="351" mass="38559" checksum="46AFA71552C27612" modified="2013-07-24" version="1">MYESELALRLTPYVAGEQPKNRKFIKLNTNENPYPPSPRVAEVLRSFDASSLRLYPDMDATALREAISAVEGVPADWVFCGNGSDEVLAFAFAAFFAGKTVAIPAVTYSFYPVYANLYGAKVASVPMKPDFSVDVDGLRLACPIALANPNAPTGMALPLDVLRDLAAYTRDCGEVLLIDEAYAAFAEEVAVPLLREFDNVIITRTFSKSHALAGMRVGYALGHPRLMAAMKRIRDSFNSYPVDRLAQAAAREAELDTAYTARIVATICHDRDICRQALADAGIPVLKSRTNFLFVKASENDAAPIQQLLRDDGILVRHFSTPNLQSYLRVTIGTTEDMRIVTERLISRIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAK9</accession>
    <name>R7IAK9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000126">
        <property type="protein sequence ID" value="CDE48934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48934">
        <property type="protein sequence ID" value="CDE48934"/>
        <property type="gene ID" value="BN770_01872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25674" checksum="464D0062613A1E89" modified="2013-07-24" version="1">MENLQANLTLIQQRLAAASDGKYPVPKLIAVTKTHPAEDILPLQNLGVTDIGENKVQEIMEKLPALEKNFQIHLIGRLQSNKVKYIIDHVCLIHSVDRLSLAQEIDRQAQKHNRVMPVLIQVSPCGEAQKGGLPPEELIPFLHTVSQLPGLSVQGLMAVMPNTPDTALLDKLFADMRTLFERARAEAIPGIDMKELSMGMSHDYELAARHGATMVRIGSALMGARDYGPQGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAL1</accession>
    <name>R7IAL1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HisKA_7TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000095">
        <property type="protein sequence ID" value="CDE48308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48308">
        <property type="protein sequence ID" value="CDE48308"/>
        <property type="gene ID" value="BN770_01635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_7TM" evidence="3">
        <location>
            <begin position="55"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="547" mass="61519" checksum="EB0CE2E8A0FB2480" modified="2013-07-24" version="1">MAAAKRKSIAKLCLSLGLFVLAGFFRQADRVGAPLPSAAFFLLTNLIYIGLAMGWGFSISRRILHRCDRRWLLLGCAMAVLWLFLRTVKYRFFNDDTVTRYLWYLYYVPQILAPLFSLFAALQLGRREGDTFSLRWYLLFLPAICLIGGVLTNDLHQMAFRAAPGAATLSADYIHGWVYYLAMAWIVVLLLATGAVIYCKCRVSESRRYAWVPLCVFVGGFALCALSFANIYTFHKIPECCCLTFAAFWESCLQVGLLPTNDHYRYFFSESTVAAQIVDEQGIPIYRAKNAPELTACQLNAAAREAILLNADTRLQSAPVQDGRVYWVEDISKINRIQAQLAEINTRLSEENELIQAENELKRQRAQIEEKNRLMDEMIALVQPQLLQINQLLGEESVQKLDIQKLKQICLLGAYVKRRVNLALICDKKAVVRADELTHCLRESLTYLTQYGAVCALHQEGTDSVCSCHAQSAYDFFEDCLEAALPSLSALMVRVECGKRFSIRLMTEDAAGLPNVDKYKALGKITIDDADGALCATLAFDWGGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAS7</accession>
    <name>R7IAS7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48393">
        <property type="protein sequence ID" value="CDE48393"/>
        <property type="gene ID" value="BN770_01681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042573">
        <property type="entry name" value="GNAT_acetyltra_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027365">
        <property type="entry name" value="GNAT_acetyltra_YdfB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12746">
        <property type="entry name" value="GNAT_acetyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="243" mass="25661" checksum="7E6C9D4DE014520B" modified="2013-07-24" version="1">MSSADIRGMFAGLPGAHGIIEAALNGQGRVMTDDSARPSSAAVLAGDFLFFGGEPSEELVRRALNAENRAWIVQGSSAFLALVQAQRSGTWSERIAFDPHRQPEDAHLTALLANLPQGVALVPIGAAEMAFCRKTPWAADFVNQFTEDEYARNGLGVLVCADGAFVSGASSYAAYPGGIEVEVDTAPAYRGHGYATLAAAKLILTAHQQGKIATWDAANETSAHIAQKLGYRVTCAYQVFTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAT9</accession>
    <name>R7IAT9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000104">
        <property type="protein sequence ID" value="CDE48408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48408">
        <property type="protein sequence ID" value="CDE48408"/>
        <property type="gene ID" value="BN770_01689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="262"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="367" mass="40961" checksum="71A5AB85F2F1354A" modified="2013-07-24" version="1">MYRILIADDEPMALYSTAHAFPWADWGFDPPVLMTEAPAALDKLRTERFDAAIVDIRMPQMTGIDLIRLSGEAGLQTVFIVLSGYSDFSYVQTALRLSAFDYCLKPILPDAAQTALERLSGRIHDIRVGSDPAFLATLSSTAPLKPLFTQRGLPVPEGMLSMVLLSAEKPETLPPLLNGFQASLSFWADANEVLLFTPMTEQSLLSTLPKSPDVRVCYTVPVSQDILNPVRQLQLLRQTMAEVQPGQAPVSIYVNDCSPTFFDMLNYVDEHLSDDLSLQRLSAQFHLNYTYCSELFRAITGATFTKYLSSHRMERARTLIITTPMSISEIARQTGYSNYNHFSATFKTYFGQTPGAYRTAHQEGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB89</accession>
    <name>R7IB89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47752">
        <property type="protein sequence ID" value="CDE47752"/>
        <property type="gene ID" value="BN770_01339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8117" checksum="0E53D89F96FD7DCA" modified="2013-07-24" version="1">MNCAEIAHYLKVIGDGKEAVGLVKLYRTGQLVGAGKVGIAILGAAGIYGLGCWGYKKLVTYMEEHNHLPIEAAGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBE2</accession>
    <name>R7IBE2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48628">
        <property type="protein sequence ID" value="CDE48628"/>
        <property type="gene ID" value="BN770_01754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="225" mass="24601" checksum="77378ED5D1E1805F" modified="2013-07-24" version="1">MIDLRRITRTFPAQERKSPPLPVLSDITLRIPPGQYAAMVGASGSGKSTLMNILGCLDCPTSGVYRLHGRDVSALPPDELAKVRGEEIGFVFQGFQLIPRLTAIENVMLPLMLQGVSEPERRTRAEQLLLRVGLHSRMHHLPAALSGGQQQRVAIARALIRRPALILADEPTGSLDPDATQEILSLLEDLHRAGQTILLITHNPAVAARAERRLALQSGKIVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBG1</accession>
    <name>R7IBG1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsM</name>
        <name evidence="11" type="ORF">BN770_01864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48925">
        <property type="protein sequence ID" value="CDE48925"/>
        <property type="gene ID" value="BN770_01864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE48925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="125" mass="14189" checksum="FDCF5E100B4BD310" modified="2013-07-24" version="1">MARIAGVDLPREKRVEIGLTYIYGIGLTTSQKMLAEVGINPDTRVKDLSENDISKLRDYIEHHLKVEGDLRREVSLNIKRLVEIGCYRGVRHRRGLPVRGQNTKQNARTRKGPKKTIAGKKKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBW4</accession>
    <name>R7IBW4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ORF">BN770_01484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48002">
        <property type="protein sequence ID" value="CDE48002"/>
        <property type="gene ID" value="BN770_01484"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="68"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="362" mass="39474" checksum="E8D0EEA0ED2B2C3C" modified="2013-07-24" version="1">MQTITVPLGERSYPIHIERGLLAKTGEMIREKLGDIAVAVVSDDHVAPLYMEEVVSSMEKVGLRVCSIVLPHGEQTKCLKSLETLYAFLCEHHLTRKDAIVALGGGVIGDLAGLAAATYLRGVHFVQLPTTLLAQVDSSVGGKVAVDLPQGKNLVGAFYQPELVLVDPDSLRTLTDDFWRDGLGEVVKYGCIGDEALFRLMEENAGGGRIALMGVIGEILTHCIQYKANIVAQDEHDTGLRMTLNFGHTIAHAVETCQHYTGMRHGEAVALGMRVITAMTEEKGMTEQGTSARLNRLLDALEMPRRLPAIPEKDLLNAMTLDKKSAGKQLRVITLDKIGVCRIVPTDVDFFQGMTAQKFVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBY1</accession>
    <name>R7IBY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000135">
        <property type="protein sequence ID" value="CDE49100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49100">
        <property type="protein sequence ID" value="CDE49100"/>
        <property type="gene ID" value="BN770_00147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435691" evidence="1">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="222" mass="24458" checksum="1A85511485494418" modified="2013-07-24" version="1">MKKILSLVMALAMVLGCFAMAETTSILDADMDELLVLDRESSLNDWEGEWVLVAAYITADFAEEYDVEQSGLLAVPENAATLTITALKDATANDKVLGTMVDVASYIHDHTYDLSGELTFSDEDSYTVKSAWDEWANNVIAKVDYDPEASYNRGPAKTHVKGDDDTVRFADMTGVEIEDMETMKYIGMTTSGYLVLCYSDDNLAKKDGDMGVGYIFARVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC66</accession>
    <name>R7IC66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48097">
        <property type="protein sequence ID" value="CDE48097"/>
        <property type="gene ID" value="BN770_00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="343" mass="35748" checksum="ED880B8D83857ECE" modified="2013-07-24" version="1">MKETTFHLRDHLLFALLTVLTLILCIGVGSVSVPFRDTAEIIFRAIAGWEQPSGSAVAIILYTRLPRVLCVALVGAMLALGGCAMQGLLRNPLADGSTLGVSSGASLGAALAILSGVSIPFLPFGGTAGAAMLSAFLSLVVLLALAFALDHSLATNTLILLGVVFSMFVSALLSLLITFSGDKLRAITFWTMGNLSSASYQNALTLLATLLLCGGIILTQARALNAMSMGEEYALHVGVSVRRVKLTVMICVSAMIGMSVSVGGGIGFVGLVTPHMIRLIVGANHRRTLPACLYGGAIFLLLADLISRTILAPAVLPVGVVTSIIGAAAFLVIFLRTKRRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC74</accession>
    <name>R7IC74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000134">
        <property type="protein sequence ID" value="CDE49096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49096">
        <property type="protein sequence ID" value="CDE49096"/>
        <property type="gene ID" value="BN770_01919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="52" mass="5952" checksum="25AE109CD867F0A0" modified="2013-07-24" version="1">MTEFEHMMLLVCFSATIGTFIGTFLGLLINLIGDLVSKHRAKKRRLKENNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICD7</accession>
    <name>R7ICD7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ThrE_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000138">
        <property type="protein sequence ID" value="CDE49166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49166">
        <property type="protein sequence ID" value="CDE49166"/>
        <property type="gene ID" value="BN770_01926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="158" mass="17132" checksum="609F806B30EF73C8" modified="2013-07-24" version="1">MSYEPLGQGLWYFLTSFVGTLGFAILLHAPKRAWLPASLIGAMTYTLYWSLKQLSLDEAASMFLAALFGSLLAQFCARKMRMIATIFLLLSVVALVPGLGLYRCMEQLGHQQYALGAQTGILTMAGILMMALGIGVGSFLFKLVVSGTKKIMPGGKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICG9</accession>
    <name>R7ICG9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000087">
        <property type="protein sequence ID" value="CDE48192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48192">
        <property type="protein sequence ID" value="CDE48192"/>
        <property type="gene ID" value="BN770_01572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="165" mass="18111" checksum="957EB471D3175AF0" modified="2013-07-24" version="1">MFLGKSSENIGMTRRYGRAIGKARVHGSAPLNVPTSQTVLASVRLNGQITYTMYPGGTSGERFLDYLKNVLIPTLHKGGIVVMDNMRSHHVKGVEEVLRAAGIIPLYLPPYSPDLNPIEMLWSKMKAILRKLGCNIAVLLPQMVAHALALVSPEDCFGWFTADGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICU1</accession>
    <name>R7ICU1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carb-bd_dom_fam9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49704">
        <property type="protein sequence ID" value="CDE49704"/>
        <property type="gene ID" value="BN770_02090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447831" description="Carb-bd_dom_fam9 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="2">
        <location>
            <begin position="70"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="31107" checksum="094095110A79EF58" modified="2013-07-24" version="1">MKHFGWLRKAAASVLALAMFAAAPAALAYSDANLEAPRAKNVVIDGDLSEWDTSRCLRIDSEKQIVDQIEHWDGEADCSMEIYAMWDEENLYIAAKVWDDTPFVYREGFPLDELDAIILFFSTNPNADPNRTAYEATDWRIVQSTDEYDFFNYIDRDMIADNLGWETQGEYGDELVFDDYEAVTVRDKEMGGYILESKIPLHNLSNDKIAQLVPAAGTTVGFDFSILDVDLPCPGIHSLRMQYSAQLDGRDRKPTMHNVDENPSLWATMTFVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICV4</accession>
    <name>R7ICV4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000100">
        <property type="protein sequence ID" value="CDE48357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48357">
        <property type="protein sequence ID" value="CDE48357"/>
        <property type="gene ID" value="BN770_01671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="426"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="671"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE48357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="800" mass="89364" checksum="9930188B0DA477DA" modified="2013-07-24" version="1">MDETLDFAVARLEQYFNAMSNERAKSEIRLLDKTAELAARIAEAGVITNEQLDQYAYAQRLTGIVILDADMNAVAQTTIDGDTAAVLQSILKKPTVREIVDYPVKAYMTRTQAGDRTVDFAAVAREDAPGLVVAYAEREEEDASDMKLETLFSGFTFAMDGTVTVSDGKTIIASSSAEIVGRNVKKIEEDSIPHAQWDESGRLHIVDGMTAWSGKRTAFENYSVYAMFPDHAVYNSRNTILLYGTLIYMAIWLCFAWLRAQQSRRALERNSEQARIISAISEIYCFTFLVNVQRGTVRIIKHPVEKLMKMDSTWSMNEVVQMQAAQNVAPDFREAFISYCDLTTLAQRLKENPNLTLEFRDPKEKVYLMTTLPQNYDRRGRLESVLMVTQDVTAEKERERDYQLQLKKTAEDAERANIVKTDFLRRMSHDIRTPINGIRGMVEISRRYAGDEAKQEECREKIMTTSGFLLDLVNDVLNMNKLESGAVTLEEKPFNLRQMVSEIVTMVEGQAWHENVQVSCKTLAWNHENLIGSPMHLHQVLQNVVGNAVKYNCPGGSVTISCEEKGFDGTTATFLFTCADTGRGMSAAFQQHAFEAFAQEESGARTAYKGTGLGLPIAKELVEQMGGKIHFESELGVGTTFYITLPFRVDPNPPKAESAKPEQAASIKGAHILLVEDNELNMEISQYILEGAGAIVAQAWNGKEAVRRFSESEPGTFDCILMDVMMPLMDGLEATRTIRAMQRPDAATIPIVAMTANTFSEDEQRSREAGMNLFLNKPVDSGKMLQTVLECLKMGGENAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICX9</accession>
    <name>R7ICX9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name evidence="2" type="ORF">BN770_01927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000138">
        <property type="protein sequence ID" value="CDE49168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49168">
        <property type="protein sequence ID" value="CDE49168"/>
        <property type="gene ID" value="BN770_01927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00246">
        <property type="entry name" value="tRNA_RlmH_YbeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="159" mass="18231" checksum="599E8548E0139DDD" modified="2013-07-24" version="1">MSISVMAMGRMKEKPYRQMADEYLKRLSRYGKFEEIELPDLPEPANTSEAIERQIRDKEGEMMLSRLKPSDYVIALTIPGKMHDSPGLSRHLDELLTRGESSIVFVIGGSLGLGDAVIRRANEEMSMSKMTFPHQLARVMLLEQLYRAMKIRAGERYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDF7</accession>
    <name>R7IDF7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">BN770_01752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48612">
        <property type="protein sequence ID" value="CDE48612"/>
        <property type="gene ID" value="BN770_01752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="81"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="199" mass="21879" checksum="B46DE89054E99631" modified="2013-07-24" version="1">MPGQIEPIERMVSELSRLPGIGHKTAARLAYHIVGMPLEDVHALAAALWQGRKAIRYCDVCGNFSSAEKCAVCADESRHNGQICVVRDPRDVAAMERMHDYHGLYHVLHGTLSPMDGIGPDDIHIKELMTRLQTEPVSEVILATNPDIEGEATATYIARLIKPMGIKCTRIAHGVPVGSDLEYADEVTLSKAMEGRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDI3</accession>
    <name>R7IDI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48637">
        <property type="protein sequence ID" value="CDE48637"/>
        <property type="gene ID" value="BN770_01759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447861" evidence="1">
        <location>
            <begin position="22"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="433" mass="46340" checksum="97F53D87FFB0C0C0" modified="2013-07-24" version="1">MNAKCKKFLTMLLLVCVSIGAAGCSAYSNQRYYERAQLMMGSGEYAEAAELFHQLGEYEDSAEYALYAAALDALQRGKIELARANLLEIAPFKSADRYLRYLDALDAENEGELDSALDIYVSLGSFEDCAERAQTLEAAIPEQAIRQGRQMMSQGDYEGARDLFLSLNGYGQSRALSDACTAAIARKAYLAAEDLLGAGDYLGAMNAFAAMGDTLDAAHRAEECRSLLLKQAEEAFQAVTLETADALDEQLESLSADAAFAEIRQALAEKFGVNLSLLRAARSEHPYVLLGTYPMGESGAESDVLWQVLRVDGNQLVLLCCSVIDASSVATTSDLPMADTPDAAEISLPSAADLATLTDLTCAATPYAAAQGASAVYWLRDTLESGIHPVISETGALTLPADTEVPGIRPLALLDLTGYVFTAGDGTEENPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDP4</accession>
    <name>R7IDP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49944">
        <property type="protein sequence ID" value="CDE49944"/>
        <property type="gene ID" value="BN770_02205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="202" mass="22098" checksum="723B5CA3B4446C07" modified="2013-07-24" version="1">MKRIGKWLLGLITSALTLVLVIVLLPYAAKWIARIMPDESAAAIRASVVLSQKLEQSAKLETLHVTEESALNYEVKAAFLGTVASINADYTYEGSFGIDLQQVTMARDGSVLTLTLPAPELLLDSLTPADITRDSALYPYLDDNDLQRVLEDERVSCRERYLSGERAAELWDATVAAMEATVAQWMADAGGFTVRCERAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IED0</accession>
    <name>R7IED0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xylosidase/arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000150">
        <property type="protein sequence ID" value="CDE49683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49683">
        <property type="protein sequence ID" value="CDE49683"/>
        <property type="gene ID" value="BN770_02088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447882" evidence="2">
        <location>
            <begin position="31"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="86"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="4">
        <location>
            <begin position="454"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="660" mass="72009" checksum="F274E35E9A0144E0" modified="2013-07-24" version="1">MLTKKWMRRSLAMLGALTLTAGLWAAPAMAEEKTYTQPTLNPHVKSIIEVDGYQFIDLNSNGTLDPYEDWRLDADTRTADLVGQMTVREKIAQMQHPTYLPRADGKIPSYLNKWCNKEGIGMLLIRELNSVEAAAVSMNTIQEYAEGSRLGVPVLVSMDSVHGLSYVSGATVTGHNLALAATRDEDLVTRLAEIARDEHIAIGVRMTLSPEADIASEPRWGRVMETFGEDPDLVTKMVTAQVVAFQNGRDGLNTGAIVACMKHFPGAGPQMEGKDTSPIISSAETLQIHLKPYYAALEVNIASIMPYYSVPLELDMENSAIGSKATLQDLLRDEMGFEGIIQTDWGMIWAIQEGRGTMMGEEVSDEEAILIGITESRVDGIGGESIRLIDQMEELTNAGKIDEDILTAAATRIVKAKFELGVFENPYCDVEYAVQFVGNEEHQAVNLEAARKAMTLLKNDGILPLKQNEKQTILVCGPRAGDMDSLVGGWSSAQEGLTIADAVAAYAGENATVIYESDNVERIAELAKDADIIIVSVGEPSYQHDPPWGYDTLEITGSQQEILEAAKASGKPMVTVVTGGRPYILTWCDENTNAILEAYYPGSQGGIAIAETLFGLNNPTGKTPLQFPRDMDSVRNQEGDVSFDLENPLYDYGWGLSYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEL2</accession>
    <name>R7IEL2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purN</name>
        <name evidence="4" type="ORF">BN770_02177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000154">
        <property type="protein sequence ID" value="CDE49871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49871">
        <property type="protein sequence ID" value="CDE49871"/>
        <property type="gene ID" value="BN770_02177"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="204" mass="21967" checksum="E1E9E47E9CB694B7" modified="2013-07-24" version="1">MVRAAVLVSGGGTNLQAIIDAKRAGKIPSAELALVVASNASAYALTRAETAGIAHTVLRKEKGEAPENYGERLLTLLRENAIDVVVLAGFLTILPENVIHAYDHRILNIHPSLIPSFCGDGFYGLHVHEAALKRGVKVTGATVHFVNEITDGGDIIAQKAVEVLPGDTPETLQRRVMEQAEWILLPQALEQVAGEIAKKREEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF13</accession>
    <name>R7IF13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein LpqB GerMN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50041">
        <property type="protein sequence ID" value="CDE50041"/>
        <property type="gene ID" value="BN770_02242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448221" evidence="1">
        <location>
            <begin position="26"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="84"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="395"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="496" mass="52831" checksum="E751749A66CD7FF8" modified="2013-07-24" version="1">MKKSKFRLMALMMALLLTLTSCSRESSLIPAETLPPPSAPYAAPTDDTGLDYEQDVALYLPAKNGQTMLCFWRTAALRYDQMPAEAVLQLLLQEEGDGSAVPLKDYGSVSLAQGSAVTTAGHVCTVNLSSAALQMGIHELYMVCLSIATTLCALPDVRFVNILVAGNPVAMDVQNLLPLGALSSAEGENLVTRWEQLVAQRTGAGGIAAQTPLSSAAVLYFPLKSGSGITCEVRQLSFDGQNAQQLVYGLLDALSAGATDAANVPDMPDLRTMLLMAPEVTTLSSGRPSAAINLVPDALQRISSAGIDPVCFFAALTMTLTSYIPSLEQVVYRVGDSALTSLYSTIHGTIVLPGGMMTRANFGGLLTDEAVCYLSNGEKLRQGRLNLPASAACSPRALLTAVLATEGFPAGLTEDDVLGVAIADDTVLVNFSAHMADAIRTSRLNQRMMAYQLTGALVQRYPVRRVRFFFDGEAKNTLDGDVMWAGEFLMDYVLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF27</accession>
    <name>R7IF27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49933">
        <property type="protein sequence ID" value="CDE49933"/>
        <property type="gene ID" value="BN770_02194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="102" mass="11595" checksum="D63C1377DA1DD834" modified="2013-07-24" version="1">MSIQSKVHFWRFTLRRRWILMRMIFCGNGVARAKILKKSGVFGAMGDNCWYEPHKLPSEPQLVFMGNNVNIAADVAILNHDIMAAMINRMDGMPKCNIRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF38</accession>
    <name>R7IF38_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000165">
        <property type="protein sequence ID" value="CDE50220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50220">
        <property type="protein sequence ID" value="CDE50220"/>
        <property type="gene ID" value="BN770_02323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="168" mass="18408" checksum="BBD373D148984D26" modified="2013-07-24" version="1">MPTESPEPTETPEPTLSPEPTSTPTPAPTGKLYERVPGIEMPGEKVNGHEYIGTLSIPSLGLKVPVQRNWSYENLSVSPCRYSGSAYAGNLAIIAHTYHFGKLSSLALDATVTFTDMENNVFRYVVREKNTISPNDANEIAHSDYDLTLVTCTLSGTKRVAVYCERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF89</accession>
    <name>R7IF89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50250">
        <property type="protein sequence ID" value="CDE50250"/>
        <property type="gene ID" value="BN770_02334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19620" checksum="500E5504C9E0AAB3" modified="2013-07-24" version="1">METMQNILTRRSVRKFADKPIEPDKLHTILEAAMSGPCAVNAREWAFIVVTDREKLAQMAEANGRVARMLNQAAAAILVCGDLDRAFPPAPDFWVIDAAIAAQNMTLAANDLGIGSVWLGTWPDETRVKRQAAIFQLPETIVPHSILALGYPAEDIDMRAVRPSRYEENRVHVNQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFG5</accession>
    <name>R7IFG5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 1 CUT1 family (TC 3.A.1.1.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50345">
        <property type="protein sequence ID" value="CDE50345"/>
        <property type="gene ID" value="BN770_00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="263"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="491" mass="54223" checksum="7395E37E00FCF7A4" modified="2013-07-24" version="1">MQATISAKSGGQATCVREKTNWALIIIRILTAFAGLMIFFPEVNPGRLMSDINANTSLFTAAISYSTLTDSFARPLRMGWVQPWHFYLIMGGCALLMLGIILSAIGACMSLGNHRMKRAAVKLPLIGSVLMLGGIGTLVYLNSILPALEKAERLKLMTPTGAIVFWAMLGGLLLVFSIVSMVTIPKDMEEKMEMEEKYRLFLMFLPVLILTVIFCYLPLYGWRYAFFDYKVGDALSSENFVGIKWFSYLFSNGATRSDLVRVLRNTLIMSGLGIATSWLPIAFAVLLAELRSTKFQRVVQTLTTIPNFISWVLVYAIAFAIFSTDGFINSFLRNVMGQTATTDYLASADFIWLKMLLWGTWKGLGWSAIVYIAGIAGIDQQLYEAAKVDGANRFQCIRHITIPGLMPTYMVMLLMAIAGMLSNGMEQYLVFENPQNSATIEVLDLYVYHSGIKSGLIPLSTVVGVFKSLIGVLLLFGANGISKGVRGESII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFL1</accession>
    <name>R7IFL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell Wall Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50400">
        <property type="protein sequence ID" value="CDE50400"/>
        <property type="gene ID" value="BN770_02366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011105">
        <property type="entry name" value="Cell_wall_hydrolase_SleB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042047">
        <property type="entry name" value="SleB_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07486">
        <property type="entry name" value="Hydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="142" mass="15966" checksum="413F645586A532C8" modified="2013-07-24" version="1">MTDLELFARLIQCEAGGEGDNGMKAVASVVMNRVRTSVGEYGRYNTIPAVIYQDGQFNCVRTRLSGRTNLQNVYNMNPTNVHYEIAEWAMAGGRLANLWEALWFFNPYSSTCPNNFPSSVGYFQIRIGNHCFYNPAPSYANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFM4</accession>
    <name>R7IFM4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_01986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49372">
        <property type="protein sequence ID" value="CDE49372"/>
        <property type="gene ID" value="BN770_01986"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="302"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="533" mass="57436" checksum="771261DF0FAD6835" modified="2013-07-24" version="1">MMKYVFVTGGVVSSLGKGTTAASLGRLLKARGYKVAMQKCDTYYNFNPALLSPLQHGENFITEDGVAADLDLGHYERFIDESLKGEASITTGKIHTALVERELRGEYHGATITVVPHVTNEIKHRIITAAENSGADIAIIEIGGVAGDIESSPYLEAIRQLKWELGAGNTCFIHVALMPYLSVAGEMKTKPTQHSVKALRAIGIQPDVIVCRTEVNISQSAKDKIALFCNVPVGNVVQNRDASTLFEVPLNLEKEGLAGMVLKTLKLPNPPADLTEWTNMVARYDAPTQEVHIALVGKYVAVHDAYLSVHEALVHAGIANLAAVYVDYISSDELTAANAAERLGSYHGIILPGGFGHRGAEGMMAAANFARTKGIPCLMIGYGMQLGVVEAVRSLLSLPDANSTEVNRLANPAVVAIPRDRVDENDGRQNARMGGMDVVLTEGSRTAAIYGLTMVHERHGNRYEVDDAFLAPLHEVGVDFVGFSADGNYPEVFEIPAHPFYIGTIYHPEFLSRPNKAHPLFAAFIGAAAAHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG45</accession>
    <name>R7IG45_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Shikimate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50436">
        <property type="protein sequence ID" value="CDE50436"/>
        <property type="gene ID" value="BN770_02391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="183" mass="21349" checksum="24DD4C6DB8383BF6" modified="2013-07-24" version="1">MKLLFIIGDAAVGKMTVGQELMKITDLRLFHNHMTIEPVIEIFGRYEGKTIAEIRDVIFKNYAASDNDGMIFTMMMDFNLPSEWAYLEHVKGIFEPYGTDFYYVELIAPQEIRLKRNISENRLKNKASKRDIEASNQRLINDDKNHRCVSYEGEIPFDNYLRIDNSDIEPDEVAKLIKKTFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG55</accession>
    <name>R7IG55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50446">
        <property type="protein sequence ID" value="CDE50446"/>
        <property type="gene ID" value="BN770_02396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435858" evidence="2">
        <location>
            <begin position="22"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="693" mass="77570" checksum="D2A54EC2AA3D5D7A" modified="2013-07-24" version="1">MKKVLCACLAMLVLLCGAAMAEHFRCELPEGAWLGDTTPLREGDALLLTGGKALYRVSLADGSAEKLADMPDNVMHSVLRRDAEGQLTLTGIGYDADWNELLVTYTLNADNAWELTSRWDVREALDDENAGVGDLLVSDKAIYLTLRVEGKPQQLIYENLETSEVRQIGSFSDEEWSEVKLFLRGDTLCNPEGDYDKQMLTLHTFDPATGKVGKETYTSDTVPLWTADDLRYVNGRYYALMYDDNVRGLYSGETLETMTCITSPLTTMDSILLVTDDDVLLANGTLLMSSRIVSETSVTLVLSQTEAHNAADYMLQNGVTFRSVYDLTTADILNTKNSDVDILCITPFDTVSLKLLKTKGYFTDLSSSAILSKQVSRLYPGLQKGLTTDDGQIVGWYETVETYLPDAAMDVLEQNGMTFANTLLEMFQQITQLADEGVFADEGMAPLGYPGYSRLNMLNMSIERYLNEQQLLGNRITLNNAELQELLTYIVANVPEDEDAFPQNEDGYSLYEMDVSMPITTDCHMPMKVGESSPAAIPASVYVLVVNPYSQHKEEAIRYLEYCAQNVYDETQYRIFADMTEPLVNTYQEQRIAELAAQIASLETQEQTAEVKEQLSELRASKAEAEKYRYTIDAEDIAAWKQVAGNIVVPEENYFTADLKKLVERLSTGNLTVEAFTQEGNRYFEMVYQERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGF6</accession>
    <name>R7IGF6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate synthase (NADPH)</fullName>
            <ecNumber evidence="4">1.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_02368</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50403">
        <property type="protein sequence ID" value="CDE50403"/>
        <property type="gene ID" value="BN770_02368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043578">
        <property type="entry name" value="GltB_archl_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500061">
        <property type="entry name" value="GOGAT_lg2_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE50403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="501" mass="54377" checksum="803611F5B6E95C7D" modified="2013-07-24" version="1">MAVDFFYPAYEVVRNQDRCITCRVCERQCANKVHQYDAELGLMISDESACVNCQRCVSLCPTRALKIVKTDNTFKDNVNYTAQAMTEIYRQAQSGGVLLSAMGNPAPLPVYWDKLLINASQVTNPSIDPLREPMETRVYLGSRPEGIRRGKDGKLIDDTPPQLKLEVPIMFSAMSYGSISYNAHESLARAAEKLGTYYNTGEGGLHQDFYKYGEHTIVQVASGRFGVNHDYLNAGAAIEIKMGQGAKPGIGGHLPGRKIVADIAKTRMIPEGSDAISPAPHHDIYSIEDLRQLVFSLKEASRYTKPVIVKIAAVHNVAAIASGIARSGADIIAIDGFRGGTGAAPTRIRDNVGIPIELALAAVDTRLRQEGIRDRVSLVVGGSIRSSADVVKAIALGADAVYIATSALMALGCHLCRSCQTGRCNWGIATQIPELTQRLNPDMGCQRLVNLITAWNHEIKEMMGGMGINSIEALRGNRLMLRGVGLNEKELEILGVKHAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGG2</accession>
    <name>R7IGG2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferases including N-acetylases of ribosomal proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000181">
        <property type="protein sequence ID" value="CDE50879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50879">
        <property type="protein sequence ID" value="CDE50879"/>
        <property type="gene ID" value="BN770_00234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="149" mass="16962" checksum="834F580ED7AAC608" modified="2013-07-24" version="1">MNITLKPIDENNFLDAFHLQLRDDQTQYVSHPIRSLAQAYVYRDQCQPFGIYADARMVGYVMVIYDYDVPEYDIWHMMIDAAEQGKGYGTAAMKAVLDYIATKPFGDSGRVVLTCHQANIPAIRLYESLGFQHTGNVDEDGEEEMVKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGH4</accession>
    <name>R7IGH4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50423">
        <property type="protein sequence ID" value="CDE50423"/>
        <property type="gene ID" value="BN770_02380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="484" mass="52744" checksum="4D8FE86AD6045CA8" modified="2013-07-24" version="1">MLLTRGLTPDFDSVCALYARVTSAMHEKGIAQWNWGTYPNADQIHKSIDAGTLYVVREGNTVVAAVTLDSTFESAYDAVNWLFGGKPGTFHRLCIAPEKQRQGLGRGMMGEMLAILRSQGCTALRCDTLVNNSAALTLYQKIGMRIAGHIRYASLPDLRFAALEMRLTDDCPLLPLKMHPAFRGGKLTPWGGEKLRTVYSKDIREVPTGESLEVSCIPGLESTDDAGVKLPDLIAAYGEAFAGEYAKKPFPLLLKLIDAAEPLSVQVHPNDDYAARVENGKLGKTEAWLILDAPEGSQLVYGIKPGTTLDTLRTACEQGAAVEPLLRRVTVHPGDVCFIPAGCVHAIGAGIMLYEIQQSSDITYRFYDWDRVDKNGNRRELHLQKALDVTDLTFSLDPIPAPNKPVARVLDEKYFTLDLVNVQGEAVLPAVTAFGLLTALDGDLNVRFAGGQLTLRKGESAYIPHTAPVLTLHGKGRAALSMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGM9</accession>
    <name>R7IGM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosomal protein L7AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50493">
        <property type="protein sequence ID" value="CDE50493"/>
        <property type="gene ID" value="BN770_02418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="122" mass="12710" checksum="192125B3FED7C159" modified="2013-07-24" version="1">MDRETKLRGLMGLCVRARQATFGEDGCLKSIRGGGCAVLLLDSGASKATQDKYRGVCDNAGVQMALLPRGLLQDATGRSGVAMAVAPGGLAEQIRQNLPVEGKEEHGQQMKSENHGGGASVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGT0</accession>
    <name>R7IGT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49762">
        <property type="protein sequence ID" value="CDE49762"/>
        <property type="gene ID" value="BN770_02122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="225" mass="24769" checksum="ED83CD232EDB70FC" modified="2013-07-24" version="1">MRKGDETKREILRAAEQLFCQKGYEAASMQEIVRAAGVSKGGIYHHFASKEEIMTLLSHQHAQESAERAEAQLADAPDDLARLNLLLSACLPMRDEDAAFTAMLLPMATSPEGRAMALTYLDALSDRFHPLLEQTIAQGVQSGTLFTEIRGVAGIVLHLLGDCFFDLAGQLMQAKNDKQPCDLPALVDLLTRYRRAVEVLLNAPFGSITLLTLEDVESMAQRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGU1</accession>
    <name>R7IGU1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HPr kinase/phosphorylase</fullName>
            <shortName evidence="10">HPrK/P</shortName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
            <ecNumber evidence="10">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hprK</name>
        <name evidence="13" type="ORF">BN770_02129</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the HPrK/P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EC" id="2.7.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49777">
        <property type="protein sequence ID" value="CDE49777"/>
        <property type="gene ID" value="BN770_02129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hpr_kinase_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Hpr_kinase_C" evidence="12">
        <location>
            <begin position="129"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="10">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="10">
        <location>
            <begin position="262"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE49777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="311" mass="35159" checksum="36892F66ABA088EB" modified="2013-07-24" version="1">MVQAADFAKTLQLTVLSPSTQTEWDIRTTDLNRPGMQFCGFYEYFPFERPQVIGKVEMTYLENLEPEVRRQMLKKYFSFDIPCVIICRGMHPPEELLEAAAARNIAVYQTGMVTTKFFFTAINYLNRCLAPRVTRHGVLVSVYGMGVLITGDSGVGKSEAALELIRRGHQLVADDVVDICRVSDNRLTGECPEMVRHFMEIRGIGIIDIRAMYGIGAVAQSKSIDLVIHMEKWVEGKEYDRLGLNDEYITILGVKVPSQTMPVRPGRNLAIIIEVAARNLSMKKLGFSAARELDRRMNEMIMKRSNPDAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGW1</accession>
    <name>R7IGW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000188">
        <property type="protein sequence ID" value="CDE51049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51049">
        <property type="protein sequence ID" value="CDE51049"/>
        <property type="gene ID" value="BN770_00279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008801">
        <property type="term" value="F:beta-phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02598">
        <property type="entry name" value="HAD_BPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010972">
        <property type="entry name" value="Beta-phosphoglucomutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01990">
        <property type="entry name" value="bPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups" evidence="4">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="212" mass="23322" checksum="2AF12396643977A1" modified="2013-07-24" version="1">MQYQGIIFDLDGVLCSTDEYHYRAWKALADRLGIPFDRERNGLLRGVSRMDSLNIILEKSDKAYSQDEKNAMAEEKNTRYRQLLNQMSPADLSGDVKRTLDTLRARGLKLAIGSSSKNTPFILERMGLDGFFDAVADGNCITHSKPNPEVFLKAAEMLGLKPEQCVVVEDAHAGVEAAKAGGFACAAMGDAKEDARATYHLGKLSDLLEYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH15</accession>
    <name>R7IH15_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="12" type="ORF">BN770_00244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000183">
        <property type="protein sequence ID" value="CDE50900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50900">
        <property type="protein sequence ID" value="CDE50900"/>
        <property type="gene ID" value="BN770_00244"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="10">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="11">
        <location>
            <begin position="186"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE50900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="457" mass="49360" checksum="8B90DD32E60F8DE8" modified="2013-07-24" version="1">MNNQTTIGILGSGTWGIALARLLHRNGHDVTVWSKFPKEIENLSATRTHPALPGLVIPETVHFTCDLQTVASGKDILLFAVPSIAIRQTAESARPFIPDGQIIVDVAKGIEPDTLMTMTEVIRDELSKDGQHDHVKLVALSGPTHAEEVALDMPTSIVSACTDMQVAETVQDVFMNTCMRTYTNTDVLGVELCGAMKNIEALAVGISSGLGNGDNARAALITRGIAEISRLGLKMGCAEYTFGGLAGIGDLIVTATSMHSRNNRCGILIGQGVPPQEAVRQVGTVEGINALPAAMQLMERYQVEMPIAKAVNAVVKGEISAKDMALALMTRDKTSEVRQSELAVRFESALMRHISGGIMRRVMVIGEFADLSHEAIAFLTRAKDEGGHLTVALTGCTQDMRKSSLLALRCVDRVLELETEKLTLPELMRLYRIEVLVLAKGQDVPEMLPPTVKVKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH49</accession>
    <name>R7IH49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000178">
        <property type="protein sequence ID" value="CDE50751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50751">
        <property type="protein sequence ID" value="CDE50751"/>
        <property type="gene ID" value="BN770_00194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="140" mass="15773" checksum="773A4D05643F1353" modified="2013-07-24" version="1">MGKQISKYEYQKHGSCGLMKPIIFCGHNKELEKNAIALNVGIAGKLINAEPSRRSFKLPSIINTIIAEIPENSAIKDFDVLFNPDYQIDVLQLLIAACKKKEFAILWPGTYSDGKLMYAETGYSDFKIYDLDKYDVTCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHC5</accession>
    <name>R7IHC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49992">
        <property type="protein sequence ID" value="CDE49992"/>
        <property type="gene ID" value="BN770_02223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="387" mass="42887" checksum="55A0BE99C2975CF2" modified="2013-07-24" version="1">MLRLGIIGAGGIASLHTHNILSGKCPEVQLTAMADRKESRREWIRATVPDAAVFCEGSDLIASDTCDAVLIATPHYQHPTLAIEAFRHGKHVLCEKPAGVYTLQVRDMIAEADKHPELTFGMMFNQRTNCVYRKAKALIDSGALGEIKRMIWVVTDWYRTQSYYDAGAWRATWDGEGGGVLLNQCPHQLDLLQWLCGLPVRVRAACHEGKWHDIEVEDDVTAYLEFANGATGTFIASTGDALGENRLEIIGTRARIRIENDQLTLDTLSVDERDWCPVCKEPFGVPDIQHEIVQTDGENPQHAGVLNAFAAHILHGTPLVADGREGIRGLMLSNAMHLSSWTNQTVSLPIDEELFLKLLNEKRRTSRHKDEVDAAIDVSGSFGSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHR6</accession>
    <name>R7IHR6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000198">
        <property type="protein sequence ID" value="CDE51165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51165">
        <property type="protein sequence ID" value="CDE51165"/>
        <property type="gene ID" value="BN770_00308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="140" mass="16383" checksum="8A9F426F5D6B126C" modified="2013-07-24" version="1">MKNKNVWQAVKFTLFSASAGLIQLISFALLHDVFKIPDYNACYLPSLILSVLWNFTFNRRYTFRSDGNVKRAMLLVALYYVVFITLSRWWSTELVAVGVHDWLIEVINMLVNFVTEFLFQKFVVYRGTIDTNELARKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7II99</accession>
    <name>R7II99_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">BN770_00046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000213">
        <property type="protein sequence ID" value="CDE51335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51335">
        <property type="protein sequence ID" value="CDE51335"/>
        <property type="gene ID" value="BN770_00046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="148"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="261" mass="29248" checksum="999BE1290C60C66E" modified="2013-07-24" version="1">MARRILLTIEYDGTAYSGWQRQYNGLAVQQLIEEALTRATGEQIAITGASRTDAGVHALGQCAHFDTSSRIPPEKYPFVLNTMLPRDIRVQAGREVPDGFHARFMTCGKRYTYRILNSRHGSAIRRNTFAHIPVPLDVDAMRQALPTLLATHDFAAYQASGGTAKTTIRTIRMAEMTVQGDEIILLVEGDAFLYNMVRIIAGTLIEIGLHRRSADAFTEAFRTLDRLSLGVTAPPHGLELTKVYYPEEAFRMPEAVRWHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIB6</accession>
    <name>R7IIB6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XPRTase</shortName>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xpt</name>
        <name evidence="3" type="ORF">BN770_00037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000202">
        <property type="protein sequence ID" value="CDE51206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51206">
        <property type="protein sequence ID" value="CDE51206"/>
        <property type="gene ID" value="BN770_00037"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01184">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="33"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="1">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="193" mass="21108" checksum="2BB08CF48B1EB6AA" modified="2013-07-24" version="1">MQELQQRILQDGDILPGGVVRVERFLNHRVDTALARHIGQAFADAFRNDQIDCILTVEASGIIFAMTTALAMGDLPVIIAKKGQRRNLGDDVYTADVFSFTHQTTSTIHVGKRCLEKGQRVLLIDDFLANGEALKGLMDICRQAECHPVGAGICIEKCFQPGGETLRGMGLKVVSLAAVEKTENGKIRFLGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIF0</accession>
    <name>R7IIF0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LSU ribosomal protein L7AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51093">
        <property type="protein sequence ID" value="CDE51093"/>
        <property type="gene ID" value="BN770_00022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="80" mass="8482" checksum="DA4EE32768CB8ADF" modified="2013-07-24" version="1">MEDLKNSVSKAVGTKAVMRALKAGSAQRVYVARDIDTFLYQKVTRACEDAGVPIRRVDETKALGAACGLDIPCAAAAILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIF7</accession>
    <name>R7IIF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50367">
        <property type="protein sequence ID" value="CDE50367"/>
        <property type="gene ID" value="BN770_00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="242" mass="26275" checksum="D3425CDDACA3A8BE" modified="2013-07-24" version="1">MTMNRKLFAKGFRHGIPIGLGYLSVAFTFGMKAVADCLSPLEALLISMTNVTSAGQFAGLPLILAQASYLEVALTQLIINLRYALMSLSISQKMDSDMNTPRRLFFSFMNTDEIFAVASSQPGKVSHWYLYGLMTAPYLGWSVGTILGAVAGTLLPVFLRNALGIAIFGMFLAIILPPARKEKPVRIVVLMAIAMSLCFRYVPMLSQVSSGFVIIICAIAASALGAWFFPVREEETKAGDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIJ6</accession>
    <name>R7IIJ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000193">
        <property type="protein sequence ID" value="CDE51133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51133">
        <property type="protein sequence ID" value="CDE51133"/>
        <property type="gene ID" value="BN770_00294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435968" description="Peptidylprolyl isomerase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="6">
        <location>
            <begin position="217"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="372" mass="41568" checksum="5CAD3F48B3A1FE04" modified="2013-07-24" version="1">MKIHRLTALLLSLLLLFSCALSESTDDKLMATVNGEELRYSTYVTYLTQYQQLLSGAYDETDETQAAYIEDLALTTAIQDMLIEQDMRAKGCYDFDEETENWIQAQGQTAYETALTNVGETLRAELGYSDEEDMSSFALSYAKALGVTVEDYIAVYRKQRAMVNYYTVLLGDNPVTEDAIQSAYETNVAASKERFEGDAAAFETALYSGEEVWYKPEGYRSILQILLPAEGDTDEARLESVQATVDAIDERLNAGESFQTLMAEYNTDVAFYDADFLTVGYQVHRDSVVWDEKFVAAAFSERMAQPGCWSDPIVSDAGVHILYYLSDSKSGAIEMTDAIHDALSYTLYQDMCSEALSARLNELSDSAEVVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIM3</accession>
    <name>R7IIM3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">BN770_00051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000224">
        <property type="protein sequence ID" value="CDE51480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51480">
        <property type="protein sequence ID" value="CDE51480"/>
        <property type="gene ID" value="BN770_00051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="133" mass="15018" checksum="ADB797B09654C640" modified="2013-07-24" version="1">MKYMLDTNICIFAIKHKPPALIRNFLQHDPDDLCISAITYAELMHGVEKSQSTAQNRAAITLFLSAMAILSFDDRAAEEYGQIRVDLERKGTPIGPLDTLIAAHARSRGLTLVTNNTREFFRVENLPVEDWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIM5</accession>
    <name>R7IIM5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51634">
        <property type="protein sequence ID" value="CDE51634"/>
        <property type="gene ID" value="BN770_00536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="200"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="422" mass="46481" checksum="AAD15D8BEAD20BCA" modified="2013-07-24" version="1">MNVSAHRAFSFLRTYGYERVSCSKEERTVAEALLNECTLLGVSAQLEEFTVPCGCVSHALLRITSPYVKEYEVTGYERAASTPEGGLDTEFLYVENADEVLLEQAKGKIVLVNGYLNRATYEKLRKAEAAAILTFTGRTIDRESESDLNRCKLRETLTEPFGAIPVLNMRAASAAEIVRRGAKTVHIELIGECFDGTSQNVCATIPGTDKAEEVITLGGHYDSVYFSSGVHDNLSGSVIVLELLRYFAAHPPRRTLRFCWFGSEEQGLLGSKAYVKAHADELKDCVAMLNFDVAAPTLGSNHLVTLATDDALHYVAGVLREAGYGVRAKQDTYSSDCIPFADNGVPAINLARFGANGADYMHNRHDSLKSGYLDEHALDITLQQGFVLLDRLANAASFPLKREIAPEIRQKVDEYLFKAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIQ2</accession>
    <name>R7IIQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51510">
        <property type="protein sequence ID" value="CDE51510"/>
        <property type="gene ID" value="BN770_00467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="124" mass="14630" checksum="80D6DB844429F46F" modified="2013-07-24" version="1">MAYRGTAREYLHYLYCTLTRRKMEIDLYKVDFAKYDRIVLMIPVICGMMSAPMRSFILQEEGNLKNVEYIIIHKGLKARQPGLVRWLDRHIGQKHLACSSIWQQGKRELHITYVDGDSVLKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIU3</accession>
    <name>R7IIU3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000203">
        <property type="protein sequence ID" value="CDE51213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51213">
        <property type="protein sequence ID" value="CDE51213"/>
        <property type="gene ID" value="BN770_00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="91"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="345" mass="40504" checksum="2BB253EA616560DA" modified="2013-07-24" version="1">MAVGLFWNDRVSFEKHEWAKRFFFLGNNTGNLVFIRALKDIFHPVMIPLWDVTSDTFRDRADITHYITTELIWLTPNQTYPHVWTMLKRIGDKPLVPISVGVQSMARNVDITLHPDTVKLLRTMAERAVLGVRGEYTAAVLEKNGIVNFRIIGCPSLYQGMNEKFRVEKKPFDPKMRACCNFRTFYGTLSDPERQFLTFCANRDLGFVEQNAFPLTLENCCGDEYQFRYLQDWLKRQMHVFFHIEDWLAWVRQYDFSLGSRFHGNVIAITSGIPALTMVVDSRMDEMTRLFRLPTLPMEDFRLERPLEYYYDLADYTDFNKAYPERMRVFRDFLQRNGLAEAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIU7</accession>
    <name>R7IIU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51694">
        <property type="protein sequence ID" value="CDE51694"/>
        <property type="gene ID" value="BN770_00571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="56" mass="6293" checksum="73515D26BB13FB78" modified="2013-07-24" version="1">MKYRSAVMQAYPAANFPIFADFNHIQYQIRDPKGFADMLISIMDAGKLPGLPFITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIX7</accession>
    <name>R7IIX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51228">
        <property type="protein sequence ID" value="CDE51228"/>
        <property type="gene ID" value="BN770_00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="473" mass="51037" checksum="B18A2C3912E27CB2" modified="2013-07-24" version="1">MSPMKQSFWQSPLTRSSVPKDKVTTPETLLGYLIGPFGALLSSGIFTSYLQVYLGEALGLSSAYLSILQLVSTFLIVAANLIVGQLIERTRTMAGKARPWLLLSALTLSVASVLMFIMPFEGTARYVWIAIAYNLYYAVAYPIYNTANATMVPVSTRDSEKRSVLASMSNFAGLGVMGAGSMVFPILVQTFLSTKDEATGADVYTGFGTQWFIVMLAVAIFTALTVILQFKFTRERVTEELMESNAKEEKKQSVSMGQQLKAVTSEKWWWVIIVFYLLFQWAGAVKNGSMAYFCSNVLGGNWYMSILSILGAVPMAIAAAFVVPLANKFSKQKLTLAGLALGVVGGVIAGLGGNNLVVVGIGIALKCLGSSPACYLILAMLADVIDHVEYKHGIRTDGLTMSIYSSLMVAATPIGGAIIQALNGMLDAGTAASVNYIWIETIAYAVCAVLMIFFGVERNLKAEQQEIANRVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ07</accession>
    <name>R7IJ07_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="13" type="ORF">BN770_02449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50592">
        <property type="protein sequence ID" value="CDE50592"/>
        <property type="gene ID" value="BN770_02449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE50592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="129" mass="14156" checksum="E225DC5CE64FA3A3" modified="2013-07-24" version="1">MATRSKTKTQARQASADKRPKAIAKYVRISPRKVKIVIDLIRGKNVDEAAAILTYTPKAASPVVLKVLNSAIANAVNNQELDRKELYVAEVYANPGPTLKRYVARSRGSASPMLKRTSHISVVLDQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ79</accession>
    <name>R7IJ79_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potA</name>
        <name evidence="10" type="ORF">BN770_00625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51814">
        <property type="protein sequence ID" value="CDE51814"/>
        <property type="gene ID" value="BN770_00625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="360" mass="40114" checksum="4BAA411D965BBF39" modified="2013-07-24" version="1">MVEKEHLIDLVGISKEFDGVQVLKNINLYIRKKEFITLLGPSGCGKTTTLRIIGGFETPSEGQVLFGGQDISALPPYKRRVNTVFQKYALFPHLNVYDNIAFGLKLKKLPKKQIAEKVGQMLELVNLKGYEKRHVDALSGGQQQRVAIARSLVNEPEVLLLDEPLGALDLKLRKEMQLELKSMQQRLGITFIFVTHDQEEALTMSDTIVVMKDGTIQQIGDPKTIYDEPANAFVADFIGESNLLRGTMIHDELVEFAGTEFPCVDFGFGENTPVDVVVRPEDIMLVGEDVGQMVGTIKSVLFKGVHYEMMIDTGAYTFKVHSTTMQPQGSRVGLNIVPFNIHIMKRLEDTTPAAEVDAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJE9</accession>
    <name>R7IJE9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51899">
        <property type="protein sequence ID" value="CDE51899"/>
        <property type="gene ID" value="BN770_00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435951" description="Peptidase C51 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="79"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="268" mass="29844" checksum="42AE6A34A536F1C5" modified="2013-07-24" version="1">MKRLLRGLCALLLMTLLLPTALAAKATPTPPPVAISTEAPVQPPEQIQQVLDIAYNEWKELDGKTLKNVNKYTEWRGKGIGFGWCGGYITWCMMQANVEMEELEAVKKAAKESEDGVFVQVEGVHHVKEASVGKLLRGYQLMNRTTNVPQPGFLLVYGCSFNKTIHVALVYDVKDLGDGKYRITTLEGNMASRVKMYIHDYDMNAEVNTNKKTSTNLSEVPEDEREIPASDCVDYTVVTAKPSNSTSGKYAYYVNCFLMPYVPGEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJI1</accession>
    <name>R7IJI1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00706</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51939">
        <property type="protein sequence ID" value="CDE51939"/>
        <property type="gene ID" value="BN770_00706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="231" mass="26055" checksum="66FE862D7BC31FDE" modified="2013-07-24" version="1">MSRILIVEDEKKIARFLELELTHEGYEVQTAGDGRSGLEQAQSWQPDLLILDLMLPELSGIEVCRRLRHDSDVPIIMLTAKDDVSDKVMGLDMGADDYMTKPFAIEELLARIRVGLKKHRSSAAETPAPASNVLRAGGLVLEPSSYTVTMNNQPINLTKKEFDLLKYLMSHKGEAVTRDALLTDVWGYDYAGDTNVVDVYIRYLRHKIDEPFGVKTLHTIRAVGYMFRVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKD1</accession>
    <name>R7IKD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000190">
        <property type="protein sequence ID" value="CDE51077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51077">
        <property type="protein sequence ID" value="CDE51077"/>
        <property type="gene ID" value="BN770_00286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="5">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="4">
        <location>
            <begin position="160"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="392" mass="41869" checksum="6077B86B071C2154" modified="2013-07-24" version="1">MDYNQAALQMHEEHHGKVAVQSKVKVENRDDLSTAYTPGVAEPCRRIHADPRDVYRYTAKGNLVAVVSDGTAVLGLGDIGPLAAMPVMEGKAILFKEFADVDAFPICLDTKDVDEIVRTVKAIAPTFGGINLEDISAPRCFEIESRLHKELDIPVFHDDQHGTAIVVSAGLLNALRLVGKKMEDVNIVINGAGSAGISIAKLLLQFGAGNIVLVDRAGAVSVDEDWLNPAQRKMAEITNRHNERGSLADVMKGKDVFIGVSAPKIVTAEMVSTMAKDAIVFAMANPTPEIMPEEAAKGGARVIATGRSDYPNQINNVLVFPGIFRGALDAQATDITEEMKLSAARAIASIVSDDELKEDYIIPGAFDKRVAPAVAKAVMDCAKASGISKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKF9</accession>
    <name>R7IKF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione transport system permease protein GsiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51107">
        <property type="protein sequence ID" value="CDE51107"/>
        <property type="gene ID" value="BN770_00033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="103"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="304" mass="33199" checksum="3D080D10EC72E529" modified="2013-07-24" version="1">MMKTESISAQNRESLRQLRRRLVREQRAVSIRKFFRNKLSVVGMVLVMLMLICAVFAPLITGLLGVDPYTATMQERFQAPSAAHLFGTDNLGRDIFARVLYGAQISMTVGFTVGLLSALIGTALGLYASVNKVLDNVLMRLCDGLKAIPNILLAITLMAVLGANMKNVIISLTIVSIPGVARIARSQALLAREQTYAEAMTAVGASRTRILWRHILPNILSPIIVQMTFTFATAIISEASLSFLGAGIPSPYPSWGGMLNEARGYVYMGWWMIVFPAIFTALSVLGFNLFGDGLRDLIDPLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKM9</accession>
    <name>R7IKM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51858">
        <property type="protein sequence ID" value="CDE51858"/>
        <property type="gene ID" value="BN770_00657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435989" evidence="4">
        <location>
            <begin position="33"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1110" mass="119103" checksum="4EBC6C97C5C3A9EA" modified="2013-07-24" version="1">MKDKKWMRKALSFLLAVFMVTGSMGTVLTAAAEEPETLPTETVDVVPTEATDVPEVTEIPEATDVPEATEIPEATDVPETTEAPEATDVPEATEIPEATDVPEVTEAPEIVDEAAVDYSRSVLDNEFFDSGFAATFSSAQLYLNPTGDELVGRVTGVVYVTHRPQKGQLNERISVCVYDQTAGVAYGYLAADAVHPVPEEGIENQRHTGVFASGVEMPSALLVLAAATEEPVPTPAPTPVPTEEPVVVPTEEPVVVPTEEPAVEPTEEPVVEPTEEPAVEPTEEPAVVPTEEPVVVPTEEPVVEPTEEPAVVPTEEPAVVPTEEPAVEPTEEPVVVPTEEPASTPAPTDVPDDLENIDRADVIIPGKPTFEMDKATAELGENITFTIHTKNATKILMYIDGSVNRYIYDVPTDTSTLTMSFSSMGSKGGKRTIAFQAYNGNTPGEKSAEQTITLTKPSVKPQVTVKNIDKTTVGLGENITFTLRIKNATKVLMYIDGSVNRRFEDITPDMTEYTFTMSFSSLGNNGGKRAIAFQAYNGTTAGEKTSERVVTVANESPNKPTVTSWSLNKSTVDLNETITFTINTKNATKMRVYIDGKLNRYIYDVKDGATTFQMSFSTLGSNGGVRTVAFQPYNGNTPGAMSDTKTITISVANKPRVELLKISNPNATLGENITFTLRIKNATKVLMYIDGSVNRRFENITPDMTEYTFTMAFSSLGNNGGKRTIAFQAYNGAVGGDKTSATTISLTSGSSAAPVIANVKIDKTTAVLGEQIKFTVYLDNATKLLMYVDGQVNRRFEDVTTSMSKYEFTMSFSSLGNNGGVRTIQFQPYNGTTAGEKFKAYTITLTTTVVNKPEVVNFTMNPSRVKLNVPVTFTVNTKNATKVVLYVDGKANTSYPTTGDVTVIERAFASLGSGNGVRTIQFRPYYGTTAGELSPAQSLTLYVTDDPLTVTVPAAKQGEDLTVTWTAAGGATKYQLLLTTSDGTAALLGETAALNYTVPGLKLLQPGDYTITIKALSGNTELESVNKAFTVTGDFVFAVRDDSTSIVVVKYNGTASTLTVPSTVAGLPVVEIGAQAFEGNTKLKSVTLPATIEIIGRRAFAECKNLLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKR8</accession>
    <name>R7IKR8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000201">
        <property type="protein sequence ID" value="CDE51202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51202">
        <property type="protein sequence ID" value="CDE51202"/>
        <property type="gene ID" value="BN770_00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436729" evidence="1">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="232" mass="26020" checksum="9C17DC896377E1EB" modified="2013-07-24" version="1">MKRFIAMLLMLCSALLMTAAFAEEAAPEAKITVVEQRFINMEDDGRGFCFAKVQNTGDAAGYADYKGNIVLFDADGNIILTENYVHTKPSDVYLEPGEYAYVCESIYDDALDTAEVADCQFSIKAVDDGEEYEKLASEAKIHFEPDEEDDNYVDVTFTNTTDEILYDYEIVAALYDQNGELLFINTEMVSGIGVHPGSTITVRLYIYEDILMYFCREGLTPTTVDALVYCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKS3</accession>
    <name>R7IKS3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51908">
        <property type="protein sequence ID" value="CDE51908"/>
        <property type="gene ID" value="BN770_00688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="126" mass="13748" checksum="821FFD182C2F0440" modified="2013-07-24" version="1">MLLVEDNQLNAEIAAELLRMSGLTVDCAWDGIEAVDCLANCPDGYYDMVFMDIQMPRMNGYDATRAIRSSARNYCKRVPIVAMTANAFAEDVQAAKTVGMNEHIAKPLELATLAAVLRRYLGGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKX7</accession>
    <name>R7IKX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000205">
        <property type="protein sequence ID" value="CDE51247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51247">
        <property type="protein sequence ID" value="CDE51247"/>
        <property type="gene ID" value="BN770_00344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="284" mass="32925" checksum="8C59E9E6268F6CFD" modified="2013-07-24" version="1">MDKHFVLSKIKDYEAHLDNVAPLMESDDQLIMNELIREINNTCHVKIRGFSDLCDSYIKGAGSIIAKHINCFHSHLIRSALVFHLVGSKKHECGRVNGCEQIIWNLYNEYRNSVPFVDNSIMMEFDSAFAQLKSKKLLDQLVSLAQDPYLFSFFPQTMKMLARWRDPSMEKVIMGYFANPGLVKTQIAMSLGRSADDASILQREYSRWDSHGQYTVIICLRYYPSIQVLDKLTQFEALTVEDMEKSLSKCCTRNDRIWIKDVYSDRLFTIRKSIAEIKKQLNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL85</accession>
    <name>R7IL85_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+ transport system protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51382">
        <property type="protein sequence ID" value="CDE51382"/>
        <property type="gene ID" value="BN770_00403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="73" mass="8103" checksum="56BC1E6614BB613D" modified="2013-07-24" version="1">MKTLKDVKVGETAVVVRLHGEGAVKRRIMDMGLTRGTEVHVRKVAPLGDPMELTVRGYELSVRKADAEMIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3L8</accession>
    <name>R7I3L8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46499">
        <property type="protein sequence ID" value="CDE46499"/>
        <property type="gene ID" value="BN770_00908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022118">
        <property type="entry name" value="Peptidase_C70_AvrRpt2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12385">
        <property type="entry name" value="Peptidase_C70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435398" evidence="1">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28750" checksum="6BF68519EEA71B78" modified="2013-07-24" version="1">MKKFLSLLLSLAMLLSVAALADETRGNYSDEMKIPYAVDLSPEDGADSVERAGDHVDSPYFSRLDFYNMTSTDTLTILQHFQTMQQTSEWSCGVVSALMVMNWYGKLGDYNEQTLAQLRGTIGDKPGATSMSQMVDIFNGVGGFNCYSAIDAGEDVADIFTFEYIQQQLAAGNPIMIGWNDWGGHWQVIIGYDTMGTETTQDDVIIVADPYDTTDHNQDGYGVYGAERFLYNFTFYNFFSEESGELNDYCFLVATPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3R2</accession>
    <name>R7I3R2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xylosidase/arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46240">
        <property type="protein sequence ID" value="CDE46240"/>
        <property type="gene ID" value="BN770_00796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="7">
        <location>
            <begin position="342"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="540" mass="59322" checksum="61E05FBEBB81F992" modified="2013-07-24" version="1">MSEILWCADNGDGTYRNPVLYCDYSDPDAICVNGTYYLTASTFNYVPGLPILTSRDLVNWKLVNYAVKNIPEARYAAPQHAQGIWAPAIRFQNGRFYIYYGMPDEGIYMVSTENPLGDWDTPVLVKPGKGLIDPCPFWDDDGRAYIIHGYAKSRIGFKSWLGIFPLSPDGRTALGDDHLLYDGTKKHPTIEGPKVHKRGGWYYIFAPAGGVATGWQVCLRSRSISGPYETQVVLKQGSSETNGPHQGAWVETPEGEHWFLHFQSRGLYGRVTHLQPMTWQADGWPYIGIPDETPVPPDAIAVGEECAQAAPIANAADCGIAVETYRKPKAPECEPSGEIGDDDFSGALGLQWQFMGNWQPDFYEVGGGKLRLYARKLPDGGNRLWQCPQTLTQKIACPAFFATTTLDAAHLQAGEQAGVGFVGGQYAYTAVRRMERGVSLVFVTSEGKEHTESATETVPIQDAPVTFRVTLLPTSSSTAVVSFEYAQGGEFHPIGQPFEPARHTWVGARLALFCMPMNGGDDHGGWAEFGAVRVEAIETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4A8</accession>
    <name>R7I4A8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ppx/GppA phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46714">
        <property type="protein sequence ID" value="CDE46714"/>
        <property type="gene ID" value="BN770_01013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="301" mass="32574" checksum="14043F3E5B03B81B" modified="2013-07-24" version="1">MRAAVIGIGSNSVRMLVAEAADGEIRRISRDRAGTRLFAGLDEAGNLSREAMASSCAAVKRMADSARSQGAEKVHLFATSATRDAANNADFAALLKAETGLTLEICSGDEEAALSFFGATDGGDSGVIDIGGGSTEIIIGQGMNIRCSFSCQMGAVRLFQRIPIRDHGDLDAVEQIAADILTDKLLDYPVLSMPGSWRGTGGTFTTLAAMVKGIYWTDRTYMHGTVLTEADVARFERQLADMTLEQRKQLPGLQPNRADIVVHGICILRAIMRRMHIGQITVSEYGNLDGYFKREYLMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4I6</accession>
    <name>R7I4I6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46560">
        <property type="protein sequence ID" value="CDE46560"/>
        <property type="gene ID" value="BN770_00934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025868">
        <property type="entry name" value="Zn_ribbon_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12674">
        <property type="entry name" value="Zn_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="146" mass="16657" checksum="B9056860E47ABB81" modified="2013-07-24" version="1">MEAKDVLLKLRTEHGLSQETLAEKLFVTRQAVSRWERGDTLPNTETLKLLSKLYDVSINTLLGSPRTLICQCCGMPLDDTTISREPGGAFNEDYCKWCYTDGKFAYSSLEELLAFLVPHMSNDAWQPEQVRAYLADMLPKLKHWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4J1</accession>
    <name>R7I4J1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdR</name>
        <name evidence="10" type="ORF">BN770_00936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46565">
        <property type="protein sequence ID" value="CDE46565"/>
        <property type="gene ID" value="BN770_00936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE46565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="153" mass="17623" checksum="E16284B69BF3738F" modified="2013-07-24" version="1">MRCQYCNCAESKVIDSRPTEEGNSIRRRRECMGCGRRFTTYEKIEMLPLMVVKRDGRRETFDAQKIKAGILHACEKLPVSMQQIDAMTTSIEQRAYASMEGEISSQRIGDMVMEELKATNDVAYVRFAAVYRLFTDIGTFMQELQKLLDEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4W7</accession>
    <name>R7I4W7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ORF">BN770_00817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46268">
        <property type="protein sequence ID" value="CDE46268"/>
        <property type="gene ID" value="BN770_00817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09721">
        <property type="entry name" value="Cas1_I-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019856">
        <property type="entry name" value="CRISPR-assoc_Cas1_DVULG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03640">
        <property type="entry name" value="cas1_DVULG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="343" mass="38849" checksum="D374351669028B3F" modified="2013-07-24" version="1">MRKMLNTLFVTTEDAYLSLENENIVVHVGEEKRAQYPLLMLEGILTFSYKGASPALMGACAERGIGLTFLTPRGRFLARVCGSERGNVLLRREQYRRADSLSASCLIARNFIFGKVYNQRWVLERTIRDHALRVNVQALKDVSAALDAKLPQIESAVDLDVLRGLEGDASADYFSVFDEMILTQKADFLLNGRNRRPPQDNMNALLSFAYVLLANDCAAALESVGLDAYVGFMHRDRPGRTSLALDLMEELRAPMADRLCITLANNRVLQDKHFDRQESGAVFLNDAGRKQFLTAWQNRKREEITHPFLKEKIMWGLVPYVQALLLARTLRGDTDGYPPFLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I509</accession>
    <name>R7I509_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose synthase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46964">
        <property type="protein sequence ID" value="CDE46964"/>
        <property type="gene ID" value="BN770_01090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018513">
        <property type="entry name" value="Cell_synthase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39083">
        <property type="entry name" value="PTHR39083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03170">
        <property type="entry name" value="BcsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435391" evidence="2">
        <location>
            <begin position="27"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="735" mass="79559" checksum="687A54009547E8FD" modified="2013-07-24" version="1">MNTRYFTSRLLALMLAALLVFSCAAAEETEIPSGVVDNFVQSEIEKQQSAGDATAFEAGAAAGEYYADFTFGGVQTLSGITTTLSLYANLPKYAKPVSAVLRLSYTASDLILTDISSLTYYMNGTPFGSSKIVARSDGAQTVLYVSVPVELLTTGYNLLEILSYVRLTDDEGCRDDYNGANWVKIADTTCLRIYYEISDDADELYMYPYPFISLMNPDGAESVVAVSDAADEAELTAAMMLMAGMGNSLSAENAMTLCRLSDAKSENVLYVGLKKNTPEYLLSLLTQSVPATGALVQRATDGDTSYLLIVAEEEAALSEAAALLSDTSRVAQLHTSQTYVSVGEAQQYALASETSGLTLAGQYTIKDISGNGISFSGPFTQKMTIYLPVAKDYVLSSESRFSFDIRYSENLDFDRSLVTFYWGTSIPLYSHKLTKEGATGETLTFSVPADAIGEAGSSITVVFDLEIKDLDCTVRSMNTPWAYIAANSSLYLPAGENTTLNLANLPAPFQRASRMNNVMMILSDDATQTELTLAGRIMAMLGAGSTPYGLLKVIRAENFQAAAHGNSNLIVVGLSDRNSVLKQINPYLHFQYTDDMTSLAESTKLVMTTDYAHEASVLQLMKSPYNEAMALLTASAATEAGLQNLMARLSTEKNRWSLGKEALVVDGYGGASSYQFTVSTALTQNAEKPSFADVIVQNREPMTLLLVGMGCMLVLLLAAVLLLVRIHHRRKYDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I525</accession>
    <name>R7I525_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46343">
        <property type="protein sequence ID" value="CDE46343"/>
        <property type="gene ID" value="BN770_00827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="552" mass="58329" checksum="2EF63413EA2DC143" modified="2013-07-24" version="1">MELPSSFTMTAHVDHADLNWMMTIATAQPVKVLTDALSDHAADAHTLVSDLTAGLNALADGSDIPESNEDIHELLTALNTLFDGAAQLKDGSITLLDGVKALKDGLDTLSSNSTALNDGAAQLFAAVLDTANTQLAAAGLDALSIEVPTLTASNYAAVLDDLIAQLDPAVIDKTIEDLAKAQVREAVMAQEDKVREAVTEVVRGQVRDAVVAQEETIRAAVTDVVKEQVRQAVAAQEDTIRAAVTQAVQAQVQDAVQAQEDTIRAGVTQAVQAQVLEGVLAQAGLNMTAQQYQDAVAAGQVPDAQQKQISAAVDQMMASDDIKAKIEAAVTEQKNQLVAQNMATDGIKAKIESAVAEQENQLIAQSMASGDIKAKIESVVAEQEDKLVEENFASADVQAKLEAAVTEQIDKLVEENYASEDVQNTVAEKKATIAAAVDSLKRLKEQLASVETFVNGLKAYTDGVAQAGNGASQLYDGANTLSDGMTELSDGLAELKAKLTEEGLDLLSGDVQKALNLFDNLESQMANVPSFDLVADGMEHDMLLIIRTDLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Y2</accession>
    <name>R7I5Y2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000040">
        <property type="protein sequence ID" value="CDE47239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47239">
        <property type="protein sequence ID" value="CDE47239"/>
        <property type="gene ID" value="BN770_01177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="6">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="204"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="379" mass="41214" checksum="E625193944D80FD8" modified="2013-07-24" version="1">MKALILSTATGGGHNTAAHAVMEALTERGVECRFEDCVAFGGQKLSATVSNVYVKFVQAAPDAFGRLYRFAKAISTPRIKSPVYLFNAAYARKMEQLLTDYAPDLIVCTHMFGGQSVTYLRRHDLWNGLFAMVMTDYTIHPFVEDIECDVMFTCKAAMPSAKRLALPKSAYEFTGIPVSLSCRPCTDKRAAKEAVGLDPERPEVVLVGGSMGAGNLPEMIARILPVLGENGHLTVVCGSNVDALRRATEAYGSDPRVSLRAQVTPLTPLIAAADVLVTKSGGLTSTEAMTIGTAIVVAHPIAGCETENARYMEDNKLALWAHTDDELTAKVADLLRHPEKRAEMIAKQHEKIDPDCARKIADILIRRTNEMMGRKTPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Z3</accession>
    <name>R7I5Z3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rod shape-determining protein RodA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47075">
        <property type="protein sequence ID" value="CDE47075"/>
        <property type="gene ID" value="BN770_01131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="400" mass="44678" checksum="D0F5535F9E699610" modified="2013-07-24" version="1">MFANASRRSRAHVDVPLILMVFAMCFFGIYAVCVATYSINSTATNLLEHILESSSTLRQCFFVLVLAPLVMTLIILCPYHLIRRFTRAMYIGTTVLVLVVWVFNRAEGVKAWLDIIWDMTIQPSEFIKLALILMLAQRLSQSEHPMSTFRDFIEIMAMLLVPCAIVLFSGETGSAIVVVFAFACMLLFANVRWRLLITMAVVAILLVLALYGFMVATGSDDYRLARIVAFLNPDLSPQGDAYQMRQSQMTIGAGGLTGIGTFVDGSMSQLNYVPADWTDFIFATIGEAFGFVGCSIIMLWYLAIILRMLYLARYTYDRQGMLIIIGVIGMLLFHVFENIGMTLGRLPITGIPLPFLSYGGSNMVTNIGGIALVLNVTKNRQLTQIDSSRRFYSSYAKYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I669</accession>
    <name>R7I669_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47344">
        <property type="protein sequence ID" value="CDE47344"/>
        <property type="gene ID" value="BN770_01217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="319" mass="34508" checksum="4E2BDC8C152B6F7B" modified="2013-07-24" version="1">MGLEMVTRKPPLVLLTAYNGAAYLPAQLSSLCAQAVAFTAILRDDGSADDTPALLAAQCHQDARFRLSPTSGVHLGAVGGFFALMREAADSGAPVALCDQDDIWHPDKLTRLHAALSDAEARFGANTPILVHSDARIVDADGRPLHASLWRHQGWNPAAQSLPELLVQNNVTGCLLMMNAPLCRLCAAHQPTGDLHMHDWFIALTAAAFGRIVPIPAALADYRQHGTNAMGASTSGLFRRSLTALRTPDRIRARIALSYRNAAQFQQAYGDLLPEDAQKLLADFAQIPQLRKMARLRALRKGGFRMQSKAARAGMMLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I685</accession>
    <name>R7I685_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine nucleoside phosphorylase DeoD-type</fullName>
            <shortName evidence="1">PNP</shortName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoD</name>
        <name evidence="3" type="ORF">BN770_01161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer; trimer of homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000037">
        <property type="protein sequence ID" value="CDE47165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47165">
        <property type="protein sequence ID" value="CDE47165"/>
        <property type="gene ID" value="BN770_01161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01627">
        <property type="entry name" value="Pur_nucleosid_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Purine nucleoside binding" evidence="1">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Purine nucleoside binding" evidence="1">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="25314" checksum="FFC81A32B171D245" modified="2013-07-24" version="1">MIPTPHITAKEGDFARTVLMPGDPLRSKFIADNYLENAVLVNNTRGVQGYTGTYKGKRVSVMASGMGMPSIGIYSYELFKFYGVENIIRVGTAGMLSQQLKVRDIVLGMSAYTNSNFGQQYGFRGNVAPCCSYALLSAAMEAGKKLGVTPVPGALYSSDIFYDESQPSPGQVLQGLGVLAVEMEAAALYLNAARLGKNALTICTISDNPFTGEELDAEARQNTFTQMMEIALEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6G7</accession>
    <name>R7I6G7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47459">
        <property type="protein sequence ID" value="CDE47459"/>
        <property type="gene ID" value="BN770_01260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="59" mass="6662" checksum="8140AD4D7BE08EDC" modified="2013-07-24" version="1">MQCHRALQSVEIALTKKLINRGATRFLCLNCLGKKFGVSEETLLQKAKEFREMGCTLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6I7</accession>
    <name>R7I6I7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46858">
        <property type="protein sequence ID" value="CDE46858"/>
        <property type="gene ID" value="BN770_01057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="3">
        <location>
            <begin position="328"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="452" mass="50778" checksum="C000A4E5B0E5D369" modified="2013-07-24" version="1">MHVDLSHTPGLLYALAYWLSSTFYIQLYGSPFSKGRKFGISAGFLALIAGFMTLTDGVSAIGFFPCMGVTVALIFFYIRIATHMPWANAGYYCARAFILGEFSASLAWYLFYFFVTVPGLPLTVWTTILVFAAVHAIILYTMFLLERKYRDGSKLIKITARELFTAAVLAIAVFSVSNISFAFTGTPFSSQFTAEVFIIRTTVDLGGVAMLFAYHVVILEISTEREMEHLQALLHMQYESYRISEESIALVNQKYHDLKHHIQLLRAASAAERTEYLDQMEQQIRTYEAQNKTGNRVLDTILTAKTIQCQSEGISLTCVADGQALDFMNPMDISALFGNALDNAIESVKKLPNPEQRLIHVSAMRQKDFLRIRVENCYSGELRFVDGMPTTTKRDARYHGYGLKSIQSIANSYGGSATIDTKDGWFELRLLLPVPKEKKGEAAEKRDERTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Q0</accession>
    <name>R7I6Q0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000042">
        <property type="protein sequence ID" value="CDE47300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47300">
        <property type="protein sequence ID" value="CDE47300"/>
        <property type="gene ID" value="BN770_01201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="91" mass="10254" checksum="B324F8DEAEDC9D8B" modified="2013-07-24" version="1">MPDEYTLDVELHLDANNVVTELKLTLENEIEGLTQEMLDAFAEQFVGKQLPVVLHADADETTAEEQIVEGMENQLENSRNIIDVLNMLLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6W3</accession>
    <name>R7I6W3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47013">
        <property type="protein sequence ID" value="CDE47013"/>
        <property type="gene ID" value="BN770_01108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="29125" checksum="CE02631D9F883811" modified="2013-07-24" version="1">MMALFDSHCHVDEPKFDDDRENVLTRMAEAGVTRYAVIGSDMATSRHSADFAAAHPGCYAAIGIHPHEAKGFVEDDLQRLADWSKEEKVVAIGEIGLDYYYDLSPRETQMAVCEAQMELAWELSLPVAYHIRDAHQDMLDIMKRHRKHLTGGIIHCFSGSWEIAKEYLKLGYFISFAGPVTFKKAPKLQEAAVNVPLDRILIETDSPYLSPEPVRGRRNEPTNVRYVAEKIAALREIPLEAFAQITMQNALNAYCIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Z4</accession>
    <name>R7I6Z4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000046">
        <property type="protein sequence ID" value="CDE47420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47420">
        <property type="protein sequence ID" value="CDE47420"/>
        <property type="gene ID" value="BN770_00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="386"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="419"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="625" mass="68912" checksum="8B1CF92C66E95D10" modified="2013-07-24" version="1">MPRMSIKGQGHILKRLMKIVFENYLWQFIAVIVCIVVTAYATIQSSTFTRDLVDVYIVGIQKGTKTMGDLANAMIPLGCVLALGVAASYIRQRLMVSVGQGTMLKIRTDLFTHMESLPIRYFDTHSHGDIMSIYTNDVDTLRQLISQSIPEVINSAISVVMVFFAMLNNSWIMTILSLILLTFQMLASAKLAKLSGKHFVAQQANLGRVNGFVEEMMTGQKVVKVFCHEEKAIEQFGDLNEQLRTSAHEANRWANTLGPINNNLGHISYVICAMVGSALSIATGGTLMSTGRLVAFLTLNRNFSQPISQITQQLNSIIMALAGAERVFNLLDEAPEADNGYVELVNAKEAPDGTITETTERTGLWAWKHPHTADGSVSYRKLSGGVTFDHVDFGYTPEKTVLHDITMYAMPGQKIAFVGGTGAGKTTITNLINRFYDIQDGKIRYDDININKIRKADLRRSLGMVLQDTHLFTGTVLDNIRYGRLDATDAACMEAAKLANADEFIRKLPDGYNTMLTGDGANLSQGQRQLLSIARAAVADPPALILDEATSSIDTRTETLVQRGMDALMKGRTTFVIAHRLSTVKNSDCIMVLEQGRIIERGTHDQLIAQKGRYYTLYTGNAIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7E9</accession>
    <name>R7I7E9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47754">
        <property type="protein sequence ID" value="CDE47754"/>
        <property type="gene ID" value="BN770_01341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="45" mass="5215" checksum="87586619979D92D4" modified="2013-07-24" version="1">MTREELKGQMDELMQQYANEEIDGPTYAERMMALTTSAQTEIDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7I9</accession>
    <name>R7I7I9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ORF">BN770_01375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47814">
        <property type="protein sequence ID" value="CDE47814"/>
        <property type="gene ID" value="BN770_01375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="155" mass="18139" checksum="FFB8618CBDFCC8EC" modified="2013-07-24" version="1">MPHQKGIKSVAQNRKAWHDYFVEEKYECGLALFGTEVKSIRQGRVNLKESWAQIRGGEIWVEGMHISPYDQGNIFNRDPMRPKKLLMHKSEIRKLDGLVSRQGYTLVPLEIYLKDGRMKLQLGLCRGKAEHDKRDTIAKRDADRDIRRALREHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7N1</accession>
    <name>R7I7N1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">BN770_01399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47864">
        <property type="protein sequence ID" value="CDE47864"/>
        <property type="gene ID" value="BN770_01399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="345" mass="37121" checksum="A0760742487F850D" modified="2013-07-24" version="1">MAQLNDLGIDLGTSNVLIYQQGKGLVLRRPAVVAIERSTKKVLAIGDDAQRMVGRTPSNIMAIRPLKQGTVADFELTNTMLRFFLNGVLSKRLFSGPRVVMSVPSGVTETEKHSLINILLDAGVKRTYLLDRPLAAALGVGMDLRQRYGRMIVDMGAGITDIAVISEGEIVQSSSVYYAGDYFDDAIVRYIRKKYSLLIGERTAEQIKINIGTAMKPETDEANLAMPVVGRNQLSGLPRTQEIHAAEIYEALKDPVAALIGSIQDVLVRTPPQLASDIFDDGIVLSGGAAGLARLPEAIYTALHIPCGVADDPQTSVVLGCGIAVEDPGAYASLLDDGRKGFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7R7</accession>
    <name>R7I7R7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)</fullName>
            <ecNumber evidence="5">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BN770_00935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46562">
        <property type="protein sequence ID" value="CDE46562"/>
        <property type="gene ID" value="BN770_00935"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="13">
        <location>
            <begin position="3"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="14">
        <location>
            <begin position="82"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="10">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE46562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="525" mass="57538" checksum="99D0B05C5D14739B" modified="2013-07-24" version="1">MKKPVVLVVMDGVGETPEELGNMVKKATTPTLNELKETCPWQIIKAHGTAVGLPSDDDMGNSEVGHNALGCGQIYSQGAKLVNESIESGKIYTSDAWKNLVSDLKDNGATLHFIGLLSDGNVHSNISHLIAMLKEAKKEGVKHVRCHILLDGRDVPATSALEYVQELEDVLASLNDADFDGKIASGGGRMTITMDRYQANWPMVKAGWDTHVHGIGRQFATAKEAIEAFRAETGVIDQDLPAFVIAENGKPVGKMEDGDSVILFNFRGDRAQEISMAFDGDSSFDKFDRGEMPKVKYAGMLQYDGDLCIPKSFLVNPPEIRNTLTELLVANGVNEFACSETQKFGHVTYFWNGNRSEKFSKELETWVEVPSDVRSFDECPWMKATEITDLVVDAIKSGKYGFIRCNYPNGDMVGHTGNLLATEIAVESVDLCLARVKKACDEYGAILCVTADHGNADQMLEKNKKGKISVRTAHSLNPVPFIVYDKDERHELKDGHGFGLANVAPTVAGLLGIKPFDSWEESMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7W1</accession>
    <name>R7I7W1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ORF">BN770_01449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47949">
        <property type="protein sequence ID" value="CDE47949"/>
        <property type="gene ID" value="BN770_01449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="590"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="720"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE47949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="777" mass="86862" checksum="159F9202A4551850" modified="2013-07-24" version="1">MPRKKTNLTMPVLALRGLMVFPHMVLHFDVGRPKSVAALQEAMMNDQKIFLVAQKDVDDPDPTPENLCTVGTIANIRQVMNLPGDSLRVLVEGETRGELTTVTQEDPFLLGRIHLPKVTAPADEMELAALVRTAKDYFDAYARASQRVSQETIASIRDVDDAEQIADLIAANILTKLEDRQQILEEFDIQRRLERLCTILSREIELTGVEKQVQERVKKQIDKNQKDYYLREHMKAIQTELGDTDATDVEELRERAKNTPLNDEARQRVDKELERLSRMTPGTPEVGMSRTYIEWILDLPWGKQTTDNLDLKRARKVLAQDHYGLEKVKERIVEYLAVLKLKQDMRGPILCFVGPPGVGKTSIVRAIAKAVGRQFVQVSLGGVRDEAEIRGHRRTYIGAIPGRIISGMKQAGTMNPVFLFDEIDKMSHDFRGDPASAMLEVLDGEQNGAFRDHYLELPFDLSRVMFITTANSIDTIPTPLLDRMEVIEVPSYTEEEKLQIAKRHLLPKQVKEHGLDAGTVKISDRVMRSLIEGYTREAGVRTLERTIAKVIRKAAVTMLDEGETEVTVTEKVLHQYLGAPRFTRELPEKEPRVGIVNGLAYTTVGGETLEVECLTMPGKGGLRLTGQLGDVMKESAEAAFSYVRAHCADLGLTDDFYKDVDIHIHVPEGAVPKDGPSAGVTMATALVSVLTGIPVRNDVAMTGEITLRGRVLPIGGLKEKTLAAYRAGITTLIIPKENQKDLEEIPPHVLSQFKIVCVEQIEQVLENALTRMPERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I844</accession>
    <name>R7I844_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible L-rhamnose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47458">
        <property type="protein sequence ID" value="CDE47458"/>
        <property type="gene ID" value="BN770_01259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="32" mass="3950" checksum="5F3E2306B0E6CB81" modified="2013-07-24" version="1">MERFAWMGKIKPGMQAEYKRRHDAIWPEMKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8F5</accession>
    <name>R7I8F5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000070">
        <property type="protein sequence ID" value="CDE47890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47890">
        <property type="protein sequence ID" value="CDE47890"/>
        <property type="gene ID" value="BN770_01418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="64" mass="6855" checksum="B7C67F59FF9E208B" modified="2013-07-24" version="1">MNYFEQIAERLLQPGTFLLVLGAILVYTSGIVARKLFSGSEKANIITKIVGCVVALVGAILIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8J2</accession>
    <name>R7I8J2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BH1295 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000064">
        <property type="protein sequence ID" value="CDE47801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47801">
        <property type="protein sequence ID" value="CDE47801"/>
        <property type="gene ID" value="BN770_01363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448076" evidence="2">
        <location>
            <begin position="25"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="125"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="221"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="304"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="392"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="484"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="572"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="658"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="891" mass="94109" checksum="15B9C91EA9AFE7C9" modified="2013-07-24" version="1">MKKSIVRVLALVLMLTLVITSSAAALKLQKNDKSDNVRRLQQALTQLGYYSGTVDGSFGSGTKAAVSAFQQANSLTVDGIAGSATIALLEKQTGIDIDGNSSSSSSTATGLFKGDYSKLQYTSSGSRVRVLQQALKDLGFTISKVDGVFGQSTFEAVMAFQKATGLTVDGKAGRNTLVKLESYFDSNGNVTQPMITPKPTADLDNIAYGIPTRTLREGMGGQDVLYTQDRLAALGYLTGISDGQYGAATKAAVLAFQKKNGLSADGVLGTNTRKRLFSEGAIGAKETSQPDGVGERKLTLGMKGDDVKSVQTKLIALGYLTGKADGVYGTATESAIRRFQTRNGLTSDGICGEDTVKALYSSTAIDAGSSVTPSPKPVDESAPTRILRPGMSGDDVKSVQSRLDKFGYYSGALDGIYGAATVAAVQAFQARNGLTADGKVGANTVKILYSSNAVAADPSAATPTPTPTQSFGIVPTRTLREGSSGDDVKSVQSRLKALGYYTGTVDGNYGTGTMAAVASFQLRNNLSADGVAGTRTYKKLYSSDALSAISTPTSTPTTGVTRPTRLLYSGCTGDDVKSVQQRLKDLGYLTDKVDGKYGANTVAAMRAFQLRNGLTGSGNGDTATYTILYSVNAITAEGKQVDSTTPTVYTNLKVGATGDAVLRLQQALSNLRYTVTINGTYDETTRAAVLAFQKRNGLAPDGIAGVNTQTKLYTGDCVTGDTALPDENQNGGTGNNGASFGNGPAKSQIKLQMWYTEIKPTIKSGQTVLVYEPSSGSSFRLRFYSLGRHADSEPLTAQDTAIMKAAWGGKFSWDEKPVYVLLPSGTWVLASMHCMPHLSGSIKDNDFDGHLCVHFPRTMEETAKLDPKNGVRHQKDIRKAWKALTGEDITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8M6</accession>
    <name>R7I8M6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000090">
        <property type="protein sequence ID" value="CDE48224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48224">
        <property type="protein sequence ID" value="CDE48224"/>
        <property type="gene ID" value="BN770_00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="74" mass="8314" checksum="6806FB713E7CD794" modified="2013-07-24" version="1">MCYVVAKNANKIGSVAIRMKLGKPVVQLKAEMNSRYLNKGIQFVTISRPSAYGEYAPYRFVDTIPEFKAEVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8P7</accession>
    <name>R7I8P7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47990">
        <property type="protein sequence ID" value="CDE47990"/>
        <property type="gene ID" value="BN770_01475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="105"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="209" mass="21415" checksum="CB8C10A5FA7F9B91" modified="2013-07-24" version="1">MATILVTHGIPAEGFSLLSGEKIVIPKPLMQFSTDELAALIPAADAVVACGALPGEIIRKGTKLRIIAGYGAGYDGVDVRAAAECGIPVTNLPDTVTDSTAELAIGLMLAVSRRIGENSLRAREEAPENLFGMGKNMGRSLRGQTLGLLGCGRIGKRTAEIAAALGMRCIGYSRHGVNHPQGESVTVQPARGESSAGGKRDPAGAAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8U2</accession>
    <name>R7I8U2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">BN770_01429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47916">
        <property type="protein sequence ID" value="CDE47916"/>
        <property type="gene ID" value="BN770_01429"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="7"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="350"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="410" mass="44463" checksum="4CC276CAE659D771" modified="2013-07-24" version="1">MELNVIRQADPQVADAIEAELNRQRSHIELIASENFVSPAVMAAMGSCLTNKYAEGYPAHRYYGGCECVDVVENLARDRAKQLFGCEYVNVQPHSGAQANTAVYFAMLQPGDTVMGMSLSNGGHLTHGSPVNLSGKYFHFVPYGVDAQGYIDYDAMRALALECKPKMIVSGASAYPRTIDFEKIRAICDEVGALMMVDIAHIAGLVAAGQHPSPVPYADFVTTTTHKTLRGPRGGMIMCREQYGKAIDKAIFPGTQGGPLMHVIAGKAVCFGEALKPEFKDYQAQIIKNAKALEAAFRAEGIKMVSDGTDNHLLLLDFSDTEMTGKLLETLLEEANITVNKNTVPNETRSPFVTSGVRVGTPAVTSRGFKEADMAKVAKWIARVVREGENAVPSVKAEVEAFMKGFPLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8U6</accession>
    <name>R7I8U6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 8 (cellulase D) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46942">
        <property type="protein sequence ID" value="CDE46942"/>
        <property type="gene ID" value="BN770_01085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002037">
        <property type="entry name" value="Glyco_hydro_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01270">
        <property type="entry name" value="Glyco_hydro_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="533" mass="57152" checksum="9862E91992D19A8E" modified="2013-07-24" version="1">MKKQSYQRILAVLISLMILLTAGMAIVGAGLLQTREDSPDILPEATATADSGDLLMSSDLVPDPTKWFLPYDGDLTDADGNPVRLSALRGKTTILLFWSSWCPDCQVYLAGDFGAAVQAAQAAGAQVVLVCREGIRGDTHEKAEAELTECGITGIPLYMDADAALFHTLGLRSVPSLAVFDSQGQLLRATADMPNADEMAQLLDAAQRPAQQTLAFLKRLMQADGAIPSTYTLSGGEVHPGDTVLSETMGQTMLYAAQTEDAALFSDAWRYVRDKMTVGGLTVWRIQAGEKAAANASLDDLRILRALMEADAVWGGYEREIRERAAALYAACVVDDALVSFANVDGSGRGDRVTLCYLDVETMRALSAYDVRWTAVANRSEAILTDSRALMSSELPLYRASYTPAKDMFSNAAAQMTEAALTILHAAQISAAREQTLDWLDAQLGAGAIYAQYASNGQVGYGFRYEAIGSYAVLAQVGAVSGHTELARLSLAKLENRRTATGTFAGAYGSVKGETSYTFDELEALFALMAMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8W0</accession>
    <name>R7I8W0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48050">
        <property type="protein sequence ID" value="CDE48050"/>
        <property type="gene ID" value="BN770_01509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="4"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="359"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="766" mass="83042" checksum="B2ECD729A6BDF545" modified="2013-07-24" version="1">MMKVAEPIGVVAAVIPTTNPTSTAIFKTLICLKTRNGIIISPHPRAKKSTIAAAKVVLEAAVAAGAPEDIISWVDVPSLELTNMAMKEADIILATGGPGMVKAAYSSGKPALGVGAGNTPAIIDESADVKVAVNSILHSKTFDNGMICASEQSTIVLDSIYDAVKAEFAKRGAYFLEGEELDKVRKTIIINGALNAKIVGQKAHTIAKLAGVDVPETAKVLIGEVESVDISEEFAHEKLSPVLAMYRAKDIDDAFDKAEHLIADGGYGHTSSIYLNAVTRKDLIDRFAARMKTCRILVNTPSSQGGIGDLYNFMLRPSLTLGCGSWGGNSVSENVGVKHLLNVKTVAIRRENMLWFRAPEKVYLKKGCLPVALNELKAVMGKKRCFIVTDAFLFKSGFTKAITDKLDELGIVHTTFYDVAPDPSLACAKEGAKAMTSFQPDCIIAIGGGSAMDAGKIMWVMYEHPEVDFLDMAMRFMDIRKRVYTFPKMGEKAYFIAIPTSAGTGSEVTPFAVITDQDTGVKYPLADYELLPKMAIVDADMMMSAPKGLTSASGIDALTHALEAYASMLATDFTDGLAKQAAQLIFEYLPACYDNGQNEPVAREKMGNAATMAGMAFANAFLGVCHSMAHKLGAFHHLPHGIANALLIELVIRYNSAEVPTKMGTFPQYAYPHTKRRYAEFGEFLGFKGANDDETVENLIRNIHALKERVGIKNTIRDYGVDEEKFLATLDEMSEQAFDDQCTGANPRYPLISEIKEMYLKAYYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I955</accession>
    <name>R7I955_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000104">
        <property type="protein sequence ID" value="CDE48409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48409">
        <property type="protein sequence ID" value="CDE48409"/>
        <property type="gene ID" value="BN770_01690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="315" mass="35324" checksum="B83201372392ADBA" modified="2013-07-24" version="1">MAKEHAMIESGRRQSLGKRIWKNRWVYLFLLPGIAFVLLFCYGPMYGLVVAFKDYKISKGILGSPWANPWYNNFAMMFKDKKFNAAFFNTIRMGLAYIITGFPGPIILALLLNELRSRHYKNTLQVIYTFPNFLSWVIVGGLMTTIFAGEGVINSLIRASGGQTYGFLTDKSLIRPLLYATSIWKGTGWSAILYLAGIAGISPELYEAAEVDGANRFHKMWYITWPEIRSTAVILLILAFGGIMSKGYDQILNMTNAVVRDAAETIDTYIYRITFQEKPKYGFSTAIGLSKSVINFAFLLLANKLAKALGEGGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9G7</accession>
    <name>R7I9G7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48136">
        <property type="protein sequence ID" value="CDE48136"/>
        <property type="gene ID" value="BN770_01551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="357" mass="41904" checksum="7404EA95D1C5CF04" modified="2013-07-24" version="1">MSDILRKFRRGATLLGELIKYEAAALCANVLKVTNPRYRHVWLVSERGREARDNGYHYFAYLRREHPEINAVYVADPKLPDYDRVAQLGSVVPYRSWRHYLLCAASEMKVSTHVSGYTPDIERYYMLDKLHIVRGKKVFLQHGIMIDDMKWYHYPNVVMDLFVTTLQKERDFVESAFGYPKGVVRRLGLCRYDALLHPHETKRQVLFMPTWRTYAVEGKTQAEFEQTDYFQHWQAVISDPELEKLLTKYGYDAVFYPHFEVQRFLSAFHTEHPHVKIGALGQMDVQTLLMESALLITDFSSIQFDFAYMLKPEIYYQFDEARYWGTHHDRGYFDYRVDGFGAGVATQEALLQAIGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9J5</accession>
    <name>R7I9J5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48240">
        <property type="protein sequence ID" value="CDE48240"/>
        <property type="gene ID" value="BN770_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="396" mass="45935" checksum="2CB18499AE2FE121" modified="2013-07-24" version="1">MPAYTSVLQKPLETIFWEDDNFMEELLQVVRLFRPFSAAITEFISEHGYQGDTSDIDAKVAFIRTAFAKADMDAPREVREWFTLQQPIKRDTVFQICFAFGLDGGETDEFFRRIFTRERSFNCHQMPEAIYYFCLNNGLTWTDAMDIQSSVSLSGKEKTNGDIVYTGSIIAELNNLQDKDDLIHWLNDNIDKFTGSNVTAYDTIRRLWEEVSGPDGLLIQERKSLPSIHDDAATGEKSKLRSNASGVRSYDAYLAILQLDKKEVKRLATDRSIKPILERLHDNAQDSFPDRQGIELILRGEIVSYERVRKWLVLLTFYTYWVRKALRKGNYEADSGDADRCITSMNQHLINSGYPELYVGNPYDWIFFYAAKCEEPLYVFRYIWNELLTGVLERHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9K1</accession>
    <name>R7I9K1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polypeptide-transport-associated domain protein FtsQ-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47973">
        <property type="protein sequence ID" value="CDE47973"/>
        <property type="gene ID" value="BN770_01463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="9">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="343" mass="38237" checksum="8499D4969DA25898" modified="2013-07-24" version="1">MTQDNWQPGTPPGGRRRTQHPTAENPFEEPEQSPELRQERSPDLYRATNPFWNQPFRDAESASAPPDLGEPPQNPPPEASVWSHPPVLDTDSYSEETQKRHHRTRRVWKAIVPLALAILFVAFLFGGVLIVRNIKVTGNVRISAEEIIRLSKLKLGQSSLINEKEISNRIEQNPYLICRMVSLESFDTICIEVKERQEVTFLTTSGIGVITDAHGYVLRTVQNANESHPELVRVQGLSVKKTIIGQKLIANQQKQLDAVTEVLLQLTVMGGLDQIAVLDVSSLDRIRMQTMDGMEIVLGDSSLLHEKLRAFLIVRTELSAMGKTGGTLTLTDAVNPVYAPPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9M9</accession>
    <name>R7I9M9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ORF">BN770_01571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000086">
        <property type="protein sequence ID" value="CDE48191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48191">
        <property type="protein sequence ID" value="CDE48191"/>
        <property type="gene ID" value="BN770_01571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with target base in tRNA" evidence="7">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="304"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="365" mass="40567" checksum="F9474657F7A02811" modified="2013-07-24" version="1">MSERIVVGMSGGVDSSVAALLLKQQGYDVVGVFMKNWEETDESGVCTAENDWNDVREVCEIIGIPYYAVNFSREYWDRVFSYFLKEYRAGRTPNPDVLCNREIKFKAFLDFAMQLGASKMATGHFVRTNENGDLLRGIDPNKDQSYFLYMLHQEQLRKAIFPVGGMTKTEVRRIAEENGLPVCKKKDSTGVCFIGERNFRQFLSTYLPAQPGDMVAPDGSVVGHHDGLMYYTLGQRRGLGIGGCGDGRSWFVIGKDLESNRLLVAQGEDHPMLYSTMSIGAEATWIGADPLAGGEPLHCTCKFRYRQGDQPVEVRRDGEKLLIHALTPQRAVTPGQSAVFYQGEKCLGGAIVEQILDAGQGKMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9P8</accession>
    <name>R7I9P8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000095">
        <property type="protein sequence ID" value="CDE48310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48310">
        <property type="protein sequence ID" value="CDE48310"/>
        <property type="gene ID" value="BN770_01637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="225" mass="25562" checksum="7DBD4DA436AB6549" modified="2013-07-24" version="1">MRILIVEDERALCDTLVKSLKQKGYEVDACYDGDSALDWLLTEKYDLLLLDLNLPGRDGMDLLKTLREQDQETRVLILSARSRISDKVEGLDCGANDYLVKPFHLEELEARVRSLTRRSFVQHDAVLRCGELSFDTVKRTAQVRGEVVALTRKENGILEYLLLNQGRPVSQEELMEHVWDGSVNSFSNSIRVHISSLRKKLKAALGYDPILNRIGEGYLMGGREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9Q3</accession>
    <name>R7I9Q3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48028">
        <property type="protein sequence ID" value="CDE48028"/>
        <property type="gene ID" value="BN770_01504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435665" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="88"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="598" mass="66364" checksum="50D09F0294E61C90" modified="2013-07-24" version="1">MKKLTALLLAIAMMVTCTLCAVAEDGKTYMAVCIASEPDTLDPALNSAVDGATMVAHLFAGLSTWAQTDDGKLEILPDCAVELPDPVVNDDGTVTYTYTLVDGLKWSDGKDLTAKDFEFAWKRAASSELGADYGYMFEVIKGYTADGSDPKAENLAVTAVDNKTLTVTLNNPVAYWNELLAFPAYMPVREDVVANEAWATDPSTYIGNGPYTMTAWEHNSKITLTKNPYYHAVDKVTMDELDFYLSDDANNMLANFQKGDWQLIDDVPTSEIASLKEQYPTEFVIAGQIGTYYVCWNINEEILPADVLANMTPEEAEAARAEVRRAIGLLFDRNYIVEEIGQAGQVPASSFVPMGMTDADGSEFYKNAGHVEGITGYYDVTDDEDVYMANFDKAVETLKKYYTYDEANAVFTNFPSLTYLYNTSEAHKAIGEYLQSAVSAVGITMNLTNQEWNTFLNTRKSGDYSIARNGWIADYNDPICFLDMWVTGSGNNDVQFGKGANADLKIYNLDLTPYGYDVKVENGTWAETYDVLISAIKSCTDSANRYAMMHIAEDMLMDTGCIVPLYYYTDIYMIDDSVQGFFSNPLGYKYFMHCTIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9S3</accession>
    <name>R7I9S3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000097">
        <property type="protein sequence ID" value="CDE48340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48340">
        <property type="protein sequence ID" value="CDE48340"/>
        <property type="gene ID" value="BN770_01662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="141" mass="15827" checksum="8E40C0DDF36F43B0" modified="2013-07-24" version="1">MTVTVQDVMRQMRNYFIASTLTGTFTVADGIIDLDPPLAPGAWVAIEGSGSLDGVHQLDENGKLPDAADGSWRGLLHLLSPTADFLRLCRDIRDWADKHPDETLLTEKFGSYSRSQSSSAWEKVFERRLRPYLRMFPEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9T0</accession>
    <name>R7I9T0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48058">
        <property type="protein sequence ID" value="CDE48058"/>
        <property type="gene ID" value="BN770_01517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="51"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="284" mass="31444" checksum="55050CBF628354B7" modified="2013-07-24" version="1">MRQTRTVSLDTLEYLYVPDVAYATYGETQRKMQLIIPYRPHWPDGETVPLIVFLPGSAWYRQEMYNCIPALAKLAERGFAVASVQYRESKIAPFPAQVEDVHRAIHYIAEQLAKLFHIDMARTFLMGNSSGGHIALLTALRQAAGIADVSELLNFPICGVIAESAPSDLFLCAKEGVPANMPATFRPTADLLGVSCLQEHPEKLAEASAQTYLAPDRAVPPILLLHGDRDTQVSAAHSRTLYERLTQNGAEADYIELAGVNHGGAPFWTEDVLQIIADFIHKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9T8</accession>
    <name>R7I9T8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48068">
        <property type="protein sequence ID" value="CDE48068"/>
        <property type="gene ID" value="BN770_01525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435669" evidence="1">
        <location>
            <begin position="26"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="535" mass="59622" checksum="B5385B47BFDEC3AA" modified="2013-07-24" version="1">MKRIVSLVLALAMVLSLCIFTTASADNGFVDGKFTETRHITVEVYNRYNDGGSDPTSSVYAQYIKQGMLDKYNVDVELVSVGRWTEVDDLNNLLATGDAPDVCVTYSYPTIQTFAGMDGIIDLNPLLTEYKDLLPDLWALLGDYNIYYDQDPETGSVWAIEAVLAESARINTFIRKDWLDKLGLKLPTTEEEFHNCLIAFRDNAELLLGADAAKMVPFSISTDIGWRADLLNVSKVPEDVSDETLYVYGYDDRHLLYPNYKEGIRVLNQWYNEGLIWKDFALYTDASVEDDMMKSGFVGAFIHNWDYPYRNGEDSIQANLTRANGADAGFIAVDCFQNDAGITRKYLADRIDRKVFFPATNDEPLASLLYLNFISSEETIKFLQTGKEGVTYKMTDNGAYEMLNATGEWIMNSGMNIDHTITVNGLYLGDATAATKALSYPGVNPDFIITANTYGKLNGRIVKKFSCGAISAEEDVGTSLNSKRDAMLTQAVVAPVDQFDSVYDKGMADYLASGGQNIIDERREKLEAIYGVHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9Z7</accession>
    <name>R7I9Z7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48123">
        <property type="protein sequence ID" value="CDE48123"/>
        <property type="gene ID" value="BN770_01543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="295" mass="32360" checksum="D4640F38CA7E25D2" modified="2013-07-24" version="1">MKPDLHTHTTSSDGLLTPAELLALADKHRVTLLAVTDHDTFDGAAQLLGKPAPMPILQGVELSLRDMPGLHLLGYGRGTDTPLHRKVRALSQMRLGRARQMVEKLNALGYPLDYDEIAREAKGSVGRPHIARAMVSHGYVVDTREAFDRFLADGAPAYVAGERLSMAEALPLMRESGFVPVLAHPMELEKTGALLRHLLGVWQEQGLRGVEVYHPSAGRATPLLDLTARRMGFLVTGGSDFHGDGGRHGKVGGTAARWPPATAWSAAPRRCGRGRQMMWRNCCRQWKMLKSCDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA30</accession>
    <name>R7IA30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48331">
        <property type="protein sequence ID" value="CDE48331"/>
        <property type="gene ID" value="BN770_01655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="227" mass="24301" checksum="F6640A81A6B085DC" modified="2013-07-24" version="1">MLNLEQLISDFEACIGFPYASPGTNDARGIDCSGMFVRAFRRQGASIYHGSNTIFRKYLARSGTIASAAGLRPGMAVFKWKPVTPARFSDGLGDFCHIGLVTSVSPLRIVHASTEGMAVKADSKIGKWRYWGWLKDVAETSSFNSAGDSAVSTSSSVSRPTLRTGSRGDSVRLLQTLLNRAGYELAVDGIFGTMTRCSVKGFQSERGLQVDGIVGKQTWAALEGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA43</accession>
    <name>R7IA43_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48470">
        <property type="protein sequence ID" value="CDE48470"/>
        <property type="gene ID" value="BN770_01708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014975">
        <property type="entry name" value="DUF1836"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40056">
        <property type="entry name" value="PTHR40056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08876">
        <property type="entry name" value="DUF1836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="176" mass="20265" checksum="9D128EFB3C9CC22B" modified="2013-07-24" version="1">MIAQISEFRMPRYREIPDVGLYLDQTVKYMNRYLAPLGCMEITTSMVSNYVKKGYISNPVRKQYSAEQIAYLLFIAVAKSALSMDNITRLFQMQRKTYTVQQAYDYFCDSLESTLQYTFGLTDTMERFNPADMPERMMLRATIIAVTHIIYLSSQFDAMQGQGTLPANGHLALPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA90</accession>
    <name>R7IA90_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_01576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000088">
        <property type="protein sequence ID" value="CDE48208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48208">
        <property type="protein sequence ID" value="CDE48208"/>
        <property type="gene ID" value="BN770_01576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="432"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE48208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="727" mass="80969" checksum="EAA2692375D6271D" modified="2013-07-24" version="1">MGRTVVIAEKPSVGRDIARVLGCQSSGRGCLTGGDWVVTWAVGHLVTLVEPDELDEKYKRWSFDTLPILPAEIPLKVIASSRDQFAVVRNLINAPETDRLICATDAGREGELIFRYIYEKAACKKPFDRLWISSMTDEAIQEGFRAIRSGSDYDGLYRSAQCRSQADWLVGMNASRAFTLRYDALLSVGRVQTPTLAILVKRRKEIEDFKPEEYATVTADFGDYRGMYFREGLEPDTHIPKIDDAKALAAQIKNQSATVISAETTRRRDLPPQLYDLTSLQRDANRLLGFTADKTLKLAQSLYETHKALTYPRTDSRYLPPDMIPRVVQTMKVLPESYQALVPGALPDGKLPVSKRTIDETKVTDHHAILPTPKRINLDSLPEDERQLYDMVVRRMLTAFYPACEYDATKVITGVGEHQFRTNGRVVLQNGWRDVPPLANPPKAGRAKKKSADAEEETALPPLSPGDTRTVRAAEVKSDQTKPPAQHNDASLLSAMENAGRESTDEEIARQMKGSGIGTPATRAAIIERLIQVGYAIRKGKTILATDKGVQLIQIVPQELSSPEMTGRWELALDQITDGRQDADRFMDSIRKFSTFLVNFARNNRADVVFPDDGRRKKRTQSMVTRGTKIDGCVCPVCRKGGVLESPQAFFCSRAADGCHFTLWKDCLTRGGGPMLTEKLLRLLLEKQVVRGSTGAITMLDGAISFFPNGSDRASACRPLTYEKKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA96</accession>
    <name>R7IA96_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000089">
        <property type="protein sequence ID" value="CDE48213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48213">
        <property type="protein sequence ID" value="CDE48213"/>
        <property type="gene ID" value="BN770_01579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12645" checksum="38BCDB98AA73CABC" modified="2013-07-24" version="1">MMQGYDKDAAVAFITRCIRKADHPELAEDIPALVPQMIDADMAYMHEAGVLDDDGYAGDAYYEDDEAIEYIVETLAAKNALDPEQAVKLAALVDDYLDAQQMFLESQGMVEYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAE7</accession>
    <name>R7IAE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000122">
        <property type="protein sequence ID" value="CDE48864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48864">
        <property type="protein sequence ID" value="CDE48864"/>
        <property type="gene ID" value="BN770_01846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="164" mass="19041" checksum="CDB8771A7A4662C9" modified="2013-07-24" version="1">MERKIYLYDRGFWVLFRMLGIFAAALSLFLTLCFIMWIREWAFLLAILAGIVATVALLMHSRCTKRQYVVLADGRLTVGEVFGQAEKTFPLDAFPYAYLYTNMKHWETVVLSRKPLTAGRIRGLFQLNLANRRNDIVRIPCSFTKQGREIRAYFAGVYALEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAH5</accession>
    <name>R7IAH5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48263">
        <property type="protein sequence ID" value="CDE48263"/>
        <property type="gene ID" value="BN770_01609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="38"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28492" checksum="09F92D50E29F8BE8" modified="2013-07-24" version="1">MLFSSSPIRRRTFSCMRGDLTIRGTEYRPNSEKLPIAIVCHGFMANQQTVRQYTRLLAKIGYCAYCFDFCGGSVPPLGRSDGATTDMSVLTEVQDLEAVIRYAQSLPYTSDTLLLMGCSQGGMVSALTAAKHPDAVDRLVLFYPAFCIPDDARAGHMMMAHFDPQNLPEKIHCGPMPLGRCYPEAVMHMDVFREITPYTGRVMIVHGTADGIVKPDYAKKAAEAYANAELHLIDGGAHGFNRRHDTEAIRYLTAFAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAK4</accession>
    <name>R7IAK4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD_2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48929">
        <property type="protein sequence ID" value="CDE48929"/>
        <property type="gene ID" value="BN770_01868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="180"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="753" mass="84680" checksum="DA9C6F29928A5F5F" modified="2013-07-24" version="1">MEELRVSVRELVEFTLHGADIRLISGRMQDMLDGTLGHQARQKLLGDGWQAEVPLNLPILVEDEELTLVLGGRMDAFRDAADVPCVEEIKLWQGEHPPEAPIPAHRMQAVCYGHMLCVTRGLPAVDVRVVYVTRRGKVQGEFPERLTAEECRAEFQSVLLPYLRRIRAVRRHTQARNASLAALKFPYANYRPGQREMAVQVYTAIKRKKRLFACMPTGTGKSSATLFPALKALGEGLTGQVYYLTARTTQRQGALDALTRLHQQTLHLWALVIDAKDKQCPTHTLCHPDYCERAKGHFLRDTDAIEEMMNIDDWSAENVRAVADKYCLCPFEFAMSLCEIADVVICDYNYALDPAVHIRRIFDATRDVTLLIDEAHHLPERIRDMLSGSVDSAGLRKLRTVVGKAAGKKHPLYKAMTDVIRAVDNLLLPEDGSMEGTLPKLPDDFDRVCLSLADAFMDARQEHFPWEDAGGRLGDTLMPLLSFNRARQRDSADYAILWEGRRHPKITAFALDSAGYFQQATQGLSGVTCFSATLHPLPEMRLLLGGAEDDACFAMPSPFPPEHLQIRQVDVNTRYAHRPSACVEIARQITALVTRKPGKYLVFFPSFAFLRMTAERLMLPCQVQEKQMDEAARRAFLDAYRQEGGNVLSLCVLGGVFSEGIDLPGRQLDGVVVVGVGLPQVNLYQEVLRAHFERTLGDGFLYAYMLPGMQKVTQAVGRVIRTETDTGVALLLDDRYSYPAYRRLMPEHWRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAN3</accession>
    <name>R7IAN3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BN770_01761</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-C family. DnaE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48640">
        <property type="protein sequence ID" value="CDE48640"/>
        <property type="gene ID" value="BN770_01761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="13">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1084"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE48640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1194" mass="133755" checksum="56EC273C2ACBDD9F" modified="2013-07-24" version="1">MSFTHLHLHTEYSLLDGACRIPKLVERIKALGMTACAITDHGVMYGCIDFYSAMKDAGIKPIIGCEVYVCRDRLDKSAANREYSHLILLCENNTGYQNLMKLVSEGFLTGYYYRPRIDYNLIRQHSEGLICLSACLSGDLPKLLLQGRYDDAEAYVREMQDIFGEKNFYVEIMDHGIREEKIVMPRLISLAREMNVPLVATNDCHYLEEKDADAQEVLLCIQTGKTLDDANRMRMDTRQLYVKSEDEMRTLFAACPDAVDRTQEIADRCNVEFEFGVTRLPHYPVPEGETALSMLTRLTHAGLRERYPDAKETDEPWQRLNYELNVISSMGYVDYFLIVWDFIRYAKSQGIMVGPGRGSGAGSIVAYSLGITMLDPLKYQLLFERFLNPERVTMPDIDVDFCYERRQEVIDYVARKYGADHVSQIITFGTLQAKGCIRDVGRVLGMSYQDTDAVAKAIPFDLGMTLEKALTLSPLLKTMYDEQPEVHRLIDTAMTLEGMPRHASTHAAGVLITGKPVMEYVPLQRNDEVITTQYPMGTIERLGLLKMDFLGLRTLTVIRDTLDMLREQGIDMKPEDIPRDDPAVYEMISAGDTDGVFQLEGGGMRTFLTNMKPTCFEDIIAAISLYRPGPMESIPRYIQGKQNPSSIHYETEKLRPILDVTYGCMVYQEQVMQIVRDLAGYSYGRSDLVRRAMAKKKHKVMAQEREYFIHGKLNDDGTIDVPGCVRNGVPEEVASHLYDEMTAFASYAFNKSHAAAYAVVCIETAWLKRYHPVPFMAAILNSVYGNPAKIAAYIQYCRSRGIAILPPDVNRSQWKFTVAKAPDGQLGILFGLGAVKTVGQGAVDAIIRERKNGAYRDIFDFCRRIDTSECNKRVVESLIKAGAFDGMGGNRPQLLAVFESAMDANSSLRKQTVDGQISLFDMAFGGAPLVQENHTLPNLPDYPLRQRLALEKEIAGVYITGHPLDDYRDVLGKLPFSTADLDGLEEREDHGLSLDGQIVDMGGILTEVKGKATKKGAYMGFITLEDLTGQIECLVFPKVYERYQGMMAVDDLVVLHGRLSIREEEAPKLLVEKLIPLEAWHPEESAPAAPMGQSTARPVPPPKRHTSEAPKLTDAQAAAKAPRKLYLRLNRPQMDAASSTLSLYPGSVPVYLHLPAEKMTLLAPKTGWCDASDGCLNRLNALLGAENVKLLESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAX8</accession>
    <name>R7IAX8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dolichyl-phosphate beta-D-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48646">
        <property type="protein sequence ID" value="CDE48646"/>
        <property type="gene ID" value="BN770_01767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="372" mass="41535" checksum="7130E5C7463BEC85" modified="2013-07-24" version="1">MAQPPLRPQDAVMLIPSLEPDDRLPAYVRRLLDKGFQHVVIVDDGSSAAYQPIFAELDAMDGVSVTHHELNRGKGCALKTGYAYIQAHFPAASGVITADADGQHTVEDCWHLAEVLTEGKRALYLGSRNFNLDHVPPKSRHGNKITSAVFRLLYGVYLPDTQTGLRAFRMADLPFMLDVPGERFEYEMQVLIACARAKLPMIPIEIETVYENENAGTHFHPIRDSYRIYKVILGNFFLYAGSSIICFLVDNGVANLLRFALLPLLGLRGDTAIQVSGYLARLVSSPLNFVLNRNFVFKFKQDTGKTALKYALLCIVTITVSNLGVSLLDHLHVFIGGFAFIPKILMDTLLYLVNYRIQNKWIFAKSAENQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBF1</accession>
    <name>R7IBF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48801">
        <property type="protein sequence ID" value="CDE48801"/>
        <property type="gene ID" value="BN770_01820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="342" mass="38590" checksum="96908D4428D33C3B" modified="2013-07-24" version="1">MAVKMLNVPSLPNIPWQEKPADYKLSSPVWRYSENPVMGRNPTPEIARIFNSAVVPWEDGYIAVLRGEQVNGIPYVYLGHSKDGIHWDVEREKVPFVDDNGNPKMPHYAYDPRLVKVDDTYYIIWCTDFYGAAIGMAKTKDFKTFTRIENPFIPFNRNAVLFPRKVNGKFKLLSRPSDSGHTPFGDIFISESPDMEYWGHHRHVMGRGSNWWESVKIGGGAAPIETTEGWLLFYHGVATTCNGFVYSMGGAILDINEPSKVLYRCENHLLTPEEPYETTGFVPNVVFPCATLQDGDTGRIAIYYGAADTNVGLAFTTVDEVVTYIKAHSKLQWGDDIAQDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBI6</accession>
    <name>R7IBI6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="8">2.4.1.129</ecNumber>
            <ecNumber evidence="7">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BN770_01885</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="8"/>
    <dbReference type="EC" id="3.4.16.4" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48955">
        <property type="protein sequence ID" value="CDE48955"/>
        <property type="gene ID" value="BN770_01885"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="21">
        <location>
            <begin position="152"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="20">
        <location>
            <begin position="466"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDE48955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="960" mass="104409" checksum="E92AACA0CE768080" modified="2013-07-24" version="1">MKKRNDSPDFVPENDDFAYQDGHPDDPQGDDPDEYDPNWADDDDPVEVAGQADMFAHEDFWNASADDSEALPEEEKVYKHSIFKPEMKKPNFVLSIAVNVIRIFAVLVLVAGLAAVGAVVGIAKGYMETAPTLDLAAIDDQAQTSFIYDANGNLITEYKGSENRVMVSIQAMPTYLQHAFIAVEDARFYTHNGVDIKRIVGAFVSNLSSSSTQGGSTITQQLIKNTLLSSEQSYKRKIQEAYLAMQLETRYTKDQILESYLNTIYLGENYYGVYTAAQGYFGKSLGELTLRECAMLAGTCNSPYYYNPRRNFYTRQKEGVDYPAITNDRTNYVLRCMYENQYITYEQYQEALDPATAHVLEKDPNTATGMYAYAHYVEYAVDEVIDILLQLNNLEDTSANRNAMENKLRTGGYHVQLAIDTSIQSTVEDTLENWTNYPTLRDPADKVYRTRNSDGTYDETVEPQAAAVVVDYHTGEIKAIVGSRTRPTAMKTFNRAVDMTMPVGSSIKPIAVYAPAIELGASPASIVMNMPLPISGWRGSNGQDSWPRNYGGSSYAGPETLRKALVNSHNTAAAQALMTLVGVDNSVAFLHAMGIDDAHIDATPFGLSLGSSGITPMQMAVAFGVLANGGVYQQPISVLGISDSTGKVIWDGHQQQERHRVFSESTAYMVVDMLKQAVSSGTGTNAKIKGQTVAGKTGTNSDQKGVFFAGMTGYYSSALWVGHDNYKALSSKSTGSRSAAPLWQSYMSKIHQGLSNRDILEGSASDYGLVKVTTCAVSGQLATDACRSDAMGYGVVTDYWKAGTEPTVSCQMHTTQTICSVSGLLASPYCPDTVTRGVLTIPSGHPLASFIGTEYEDVLIEYLGSYAVLGASGTCPYHTSASSSGSNTMVENTLIPDAKILLSQAYAQLQSMDIVNDAQRYSAIQSAITNLEYVISLPAPTTAEVASAMGQLTQAMAGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBP3</accession>
    <name>R7IBP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49010">
        <property type="protein sequence ID" value="CDE49010"/>
        <property type="gene ID" value="BN770_01889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16707" checksum="690EF9504EB050DB" modified="2013-07-24" version="1">MDELLKECRAAEAERLLDAPKLLCGIPELLLALHERGVRHYVVTHRDLRCRDMLAQCGVLPLISGFLTHEDGYPRKPAPEMVQGCLQRYALAADDCVMIGDRPLDTRAGKAAGVRGILLDADGRFAGEKSCEARAENVAEIAEMLLPDWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBZ7</accession>
    <name>R7IBZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49021">
        <property type="protein sequence ID" value="CDE49021"/>
        <property type="gene ID" value="BN770_01897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="79"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="322" mass="36092" checksum="8A3A74FD6E42B072" modified="2013-07-24" version="1">MQGAKKKVRSVSYAKWGYVFIAPFFIVFALFQLYPLVSTIYYSFFEYFFKQGGLIQVGPKFVGWTNYLYVFSKDLPRYFGNTIIMWLMGFIPQIVFSLLLAAWFTDNRLKLKCQGFFKTVIYMPNLIMASAFAMLFFALFADQGPVNNMIQALGGEPIRFLSNIWGTRSLVALMNFLMWFGNTTIILMAAMMGISPSMFEAAQIDGATPNQTFWKITLPLIRPILVYTLVTSLIGGLQMFDVPQILTNGKGDPVRSSMTVVMYLNNFIGTSKNYGRAGAVSAIMFVICAVLCVVIMRTTRGDDERKPKPVKAAKAVKGGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC49</accession>
    <name>R7IC49_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="12" type="ORF">BN770_01910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49071">
        <property type="protein sequence ID" value="CDE49071"/>
        <property type="gene ID" value="BN770_01910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="11">
        <location>
            <begin position="11"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="805"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="525"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="839"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="875" mass="97724" checksum="7D479CEA844DE2EC" modified="2013-07-24" version="1">MSSIQDKLIPVNLEKEMKRSFISYAMAVIIDRALPDVRDGLKPVHRRILYDMEELGMTPDKPYRKSARLVGDVLGKFHPHGDSSVYDAMVRLAQPFNIRYTLVDGQGNYGSVDGDGAAAMRYTEARMTKLTPYLLEGIEKDTVDFYPNFDETLMQPAVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEVIDGVICMIDNPDCTIDDLMQHIKGPDFPTGGIILGRRGIREAYYTGHGRIEVRAKTNIEEMPNGRSRIVVTEIPYQVNKAKLVEKIAELVHDKRIEGISDIRDESDRQGMRIVIELKKDVYPQVILNTLYKHTSMQETFGANMLALVNGQPKILSLRDMVYYYLEHQKDVVTRRTRFDLNKALARAHILEGLLKALDHIDEIVSIIRASKDPNTAKTTLMERFDFSDKQAQAILDMRLARLTGLERDRLQQEYDDLEKEIARFQAILADEHLLMEVIKTEISAIRDKFADPRRTELTTIDGEIDVEDLIQEEDMVVTLTRQGYVKRTPKSIYRAQNRGGRGVTGMTTKEEDFAVQMRVVSTHDEIMFFTNMGRVYMLKCYQIPEAGRTARGTAIINLIQIASDEKVTCMVPVPGATGEHNLVMATRDGMIKKTPYSEFANLRKNGLIAINLKEGDELIGVDLTSGDDEILLGSRKGMAIRFSERHIRPMGRASMGVKSMRLDDDDIIIDMVPLEQGADVLAITTLGYGKRTNPDEYREQGRNGKGIIATKLTDKTGDLAALLMVKPDEDLMLITDDGTIIRTRAEDIRVCGRNTQGVIVMKLQEGSHVIAVARAERDEEPDAPANAADADAAEARAEGFDTSDAAESKAVQELLRRAEEDANGSDLDMDLGGEDEKDSPADDSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICJ3</accession>
    <name>R7ICJ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49216">
        <property type="protein sequence ID" value="CDE49216"/>
        <property type="gene ID" value="BN770_01941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="26462" checksum="04A16654DBF82106" modified="2013-07-24" version="1">MEQFSRTISLVGQSAFDRVHQARVAVFGVGGVGGYVCEALVRSGIAEIDLFDRDDVSISNLNRQIIALHSTIGQDKVDAMAARLKDINPHVRVNCRKMFYLPTNADEIDLSVYDFVVDAVDTVAAKLELARRCEQGGIRFISAMGAGNKLDPSCLRIADITKTSVCPLARAMRVSCKKKGIRHMTVAYSLEPMHPPVQPIAEESGRRKDIPGSTAFVPGAMGLLIASHVVRTLMAGDEPARPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICM4</accession>
    <name>R7ICM4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49231">
        <property type="protein sequence ID" value="CDE49231"/>
        <property type="gene ID" value="BN770_01949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000398-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="279" mass="31586" checksum="32B3196D5293A696" modified="2013-07-24" version="1">MWVLVNKMTPVLKWAGGKTQLLGQIASNMPSEYKHYYEPFIGGGAVLLGIVPEQAYVNDVNEQLINLYIQLKIAVEAVLEKVKELDAVPCDKERYYVIRECYNTKIAAKELDAECAALMIWINKHCFNGLYRVNSKGLFNVPYNNKVNGVSADPENLRAISNYLRKFDISITCSDFEQACAGVSEGDFVYFDSPYVPQSVTASFTDYTTDGFTEADHRRLAALYRKLDKIGAKIMLSNNDVPLVRELYAGYRIQSLDVKRMINRNANQRTGKEVLVTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICT3</accession>
    <name>R7ICT3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vitamin B12 dependent methionine synthase activation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48322">
        <property type="protein sequence ID" value="CDE48322"/>
        <property type="gene ID" value="BN770_01647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoMet activation" evidence="2">
        <location>
            <begin position="136"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="224" mass="24011" checksum="C9C64E65A14E486A" modified="2013-07-24" version="1">MDASPITPDLDEALRYAGVRADESGDMHRKMAKIAAQCMKTVTPRCTYRVSEIAWENGMPSLFGGQLVLPGRTAAVMLRSCSHAALLVCTLGTTFDALARQVQARDFADALLLDGFGGAYVEAGCNAAEREIAAKLPGKYLTDRFSPGYGDLPLDVQSPLLALTDATRRLGVTLSESNLMNPLKSVTAVIGLSDTTQQARIRGCDFCAMRTRCNLRKAGKTCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICZ0</accession>
    <name>R7ICZ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000105">
        <property type="protein sequence ID" value="CDE48417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48417">
        <property type="protein sequence ID" value="CDE48417"/>
        <property type="gene ID" value="BN770_01693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024778">
        <property type="entry name" value="Put_cellulase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12876">
        <property type="entry name" value="Cellulase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="380" mass="44191" checksum="C8E84D35AC1E4848" modified="2013-07-24" version="1">MIHPLAITMWDFSWIERRWDGAGFEDWNAALDGVKERGYDAVRIDAFPHLLSQAPEKEWLLLPVWYSNDWGSPYKVRVQLFPALINFLKACRARRVRVALSSWFREDADNVRMALSTPQAMAKCWIDTLRLIADAGLMDTILYVDLCNEFPGDFWAPYFRNDLPWMTWSCWHTDAAMDYMRTAIALVRQEYPDLPYCFSFDGENTHFYRERDLSFFDLAEHHIWMTKLNKQQFYHEVGQAKDGRFTEEAYHLLADHALDVYHGKEAYWKQLLVDGIQTLAADAKAAGLPLATTECWGITDYKDFPMLPWGWVKDLCALGVETACQTGQWALMATSNFAAPQFCGMWRDVAWHQRLTTMIHKATLPPEAEKTALGRTMRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID80</accession>
    <name>R7ID80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP synthase (C/AC39) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49401">
        <property type="protein sequence ID" value="CDE49401"/>
        <property type="gene ID" value="BN770_02000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_suC/d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="324" mass="35874" checksum="BA41F88C68DE95CA" modified="2013-07-24" version="1">MAQPSVYFSAGRLTMLQRNVLDAAGMERLLSTTSLPEARKTLSELGWTGADITDPEQLAADRVNQAAQDARALSPDPALVDCFLYAYDAANLKMLLKARLLGLSAPALSDCGTIPADTLRHAVTDHRYSTLPAAFRDAMNRLEQNIVTGIDPMSIDVAIDRAMYQLIFNRLKGTHSPVTLQYFRGHVDLLNAVALLRVRQMKKDESFFMSVLLSGGTIRAQSWRLCFAQPDMLSAMLAPYGASVTEAAKNAVMDGKRLPALEKAMDDALLELYRPFRFQICPERAAAYFLAVQRETAAVRLILAGKQNGFDAENIRERLRDLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDD6</accession>
    <name>R7IDD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48592">
        <property type="protein sequence ID" value="CDE48592"/>
        <property type="gene ID" value="BN770_01735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="88" mass="9719" checksum="801C838374DE5C70" modified="2013-07-24" version="1">MYQKNQNQTQVPNLNNASVQHPSTSQPGGMVPEARQALEDMKYEIAGELGINLKQGYNGDLPSRQAGSIGGYMVKRLIEQAERQMANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDE6</accession>
    <name>R7IDE6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Positive regulator of sigma E RseC/MucC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49829">
        <property type="protein sequence ID" value="CDE49829"/>
        <property type="gene ID" value="BN770_02153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026268">
        <property type="entry name" value="RseC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007359">
        <property type="entry name" value="SigmaE_reg_RseC_MucC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35867">
        <property type="entry name" value="PTHR35867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004923">
        <property type="entry name" value="RseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="139" mass="14126" checksum="85715FB5C2EFE5C2" modified="2013-07-24" version="1">MERTGTITAVSGDTLEVTFCRPGDCEKCHACIGGEKKHVLLVKGEGHVGDAAVVSLPEQTVVKASALAYLLPLAGLFIGMLLGALVAPQSETAGSAIGGVIGLAAALIGLTATEKKRSQSGEYAPKLLRVISAADALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDL9</accession>
    <name>R7IDL9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49914">
        <property type="protein sequence ID" value="CDE49914"/>
        <property type="gene ID" value="BN770_02185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="4"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="339" mass="38763" checksum="DAFE6B78FCAE80BA" modified="2013-07-24" version="1">MTIIVTGGAGFIGSNFIFHMLKKYPDDRIICLDKLTYAGNLSTLAPIMDNPNFRFVKADICDREAVCKLFEEEHPDIVVNFAAESHVDRSIENPEIFLKTNIIGTATLMDACRKYGIQRYHQVSTDEVYGDLPLDRPDLFFTEETPIHTSSPYSSSKAGADLLVQSYYRTYGLPASISRCSNNYGPYHFPEKLIPLMIVNALADKPLPVYGEGLNVRDWLYVEDHCKAIDLIIHSGRVGEVYNVGGHNEKQNIEIVKIICKELGKPESLITHVGDRKGHDMRYAIDPTKIHNELGWLPETKFEDGIKKTIQWYLDNREWWETIISGEYQHYYAKMYGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDM6</accession>
    <name>R7IDM6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49413">
        <property type="protein sequence ID" value="CDE49413"/>
        <property type="gene ID" value="BN770_02005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="289" mass="31526" checksum="E1104534217498ED" modified="2013-07-24" version="1">MEALLDSGFHRVVVLDGAECGLDAEQSLILAPWCYAAEKQPASDGAWIHPYYFASQKAYTAASSLVKSGAFPGLALRDEIRVKPIFARLPDFSQGTNTISYIRGIGSRFHVQILTYTPRLPATEHLLAENKPLHCGECRKCVEACPTNALEGGVFHRERCIRNWMMVGGEVPEEIRAKMGNRLIGCDVCQRVCPHNPPPQGEAHPAVPLADLLRQPKETALVLRPLIGVNLTLPNRVLSQSCLLAGCSGDTSLIPLLMPLLHHPSPAVSTHAAWALSRLQEGISFLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE52</accession>
    <name>R7IE52_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BN770_02278</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50104">
        <property type="protein sequence ID" value="CDE50104"/>
        <property type="gene ID" value="BN770_02278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="13">
        <location>
            <begin position="357"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="446"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE50104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="632" mass="69474" checksum="BDA175BCDB66CD4C" modified="2013-07-24" version="1">MSDENRQGSGNFRANNGGQKRPAGGNRMSGNRTGGKNFGGKKPLSGEKRSFGGSKPAFGGEKRSFGGDKPAYNGEKRSFGGNKPAYNGEKRSFGGDKPAYNGEKRAFGGDKPAYNGEKRAFRGDKHNDGDKRPTKSGFGGEKRPYGDKKPPFGGKPGFRSGEKRPYGGGNGERRPYPAKPAAPKVEGSDGLPARRLALEVIRAVTENDAYASLVLDEKLNKCTLPLVDRRLAARLVYDTLEHLLTLDYALNSLMAKPDTDIKLRNVLRLGACQILLEDRIPESAACNTSVALCKELGMEGLAGVCNGILRNLVRQKNEIKYPDMETEPVKALSIRYSVPEWLVERLLADWGEDAEKLMGFHQPNAAITIRPNLMKMDEAAFEQFLGSKVWEKEKGMLPFSWRIRNMAEIAHDAGFVGGKFSIQSESSMMVCLAAAPKNGMQILDACAAPGGKSCLMAEMMQGTGRVQAWELHPHRADLIAAQVQRLGLENVRPMTRDALKHREELDGTMDIVLLDAPCSGLGVMSEKPDVKYRVTAQSVDELVQLQSNLLDAVCPYVKKGGTLVYSTCSVLKDENVRQAEKFLARHPEFELLPLPETIPASVRQYETTGLQLLPQRDGIEGFYMCRMRRKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IED2</accession>
    <name>R7IED2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49990">
        <property type="protein sequence ID" value="CDE49990"/>
        <property type="gene ID" value="BN770_02222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435832" evidence="1">
        <location>
            <begin position="25"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="528" mass="59650" checksum="BFFA4367AA74C38A" modified="2013-07-24" version="1">MKKILALVCTLCLLLTALPLTALAADDDWVTLNVEMYDRSIAGFNVEDCWQLHYIQENFGDPNHIKINWIPVSRWEEGTILSTRLAGGTAPDICMTYGTDLVQQYIDMGGIMPLDDLLAEYGQELTAFLGDEVLQYGQYDVGDGKEQYYLPARRIVVATQSMFIRKDWLEKLNMEVPTNVEELYAYLKAAKEQKLGGDNTIPYSSDLYAADPFYGWIYQMDAFLDYSQITEEDWVANFKFHYMLPGAKEALRWMNKFFNEGLVSDYFGIENSKQTDSDRVNGYDGFWVGNWDAPWRMEKSYAQDLAKNVPGASWIACDPFKPEDGTTPHETYTAAGQAIFIPASVDEKVAVAAIKYLNWMCKPESLYALQNGEKGYNYTTVNENNIPTDLKNINDTDDAHKMHATDGAPICNGFYYGSDELNYAATAMGFPGYEDVVADSLVISNDGAYEPVSFTRTIQSRIDYGTTIVSKEAELLVQVVTCKPEDFDATWDKYINEILSAGGQQIIDEQREAYQEGAYRGFYPMAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEJ6</accession>
    <name>R7IEJ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49728">
        <property type="protein sequence ID" value="CDE49728"/>
        <property type="gene ID" value="BN770_02107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="230" mass="25356" checksum="4A7B868DFF65BCFD" modified="2013-07-24" version="1">MAENILTMENIVKTYKMGDEQQTVLKGIDLQVDKGEFVAILGPSGSGKSTLMNIIGCLDTATSGTYHLHGRDVSALSESELARVRSKEIGFIFQSFQLLQRQDALQNVELPLIYAGMSGHERAARAQQMLERVGLKDKMHHFPNQLSGGQQQRVAIARALANNPTILLADEPTGALDRATGRQVMSLFHDLNDEGRTIIMITHDIEIARHARRIVRILDGEISEGVVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEN2</accession>
    <name>R7IEN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50095">
        <property type="protein sequence ID" value="CDE50095"/>
        <property type="gene ID" value="BN770_02272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF853" evidence="2">
        <location>
            <begin position="12"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="664" mass="72734" checksum="DB4A0F21DEF85298" modified="2013-07-24" version="1">MLYEGKIWLGTGEHPVCLLPQMANRHGLIAGATGTGKTVSLKVLAEGFSDMGVPVFLADIKGDLAGMVQPGTHSDNIANRLTQCGVPTFEYRTFPTVFWDVFGKEGHPVRTTVSEMGPTLLARLMNLNDTQAGVLSILFRVADDENMLLLDLKDLKAMLAYVGEHAKEYTLDYGNVSMASVGAIQRAVAMLEDEGGNAFFGEPALNIADWMQLDENGRGVINILAADVLYRKPRLYSTFLLWMLSELYELLPECGDLDKPRMVFFFDEAHLLFDDCPKALLETLEQVVRLIRSKGVGVYFVTQNPCDIPMSILGQLGNRVQHALRAYTPLDQKAVRTAAMTFRANPAFDTAEAITTLKTGEALVSFLDADGAPSIVERATILPPQSAMNAIDGDVRQECIESSPFRGVYDTPVDRVSAYEMLASAFQKEQMPAPEAAAPQISTAAPTVSRPDAFLVFDLQTGHYVQREAAQPMGQAQPMGQAQPVQQPAAQGSTPRPAWMAADEPARPAWQNQQEQQPIGQAQPVPVLTVQQPQVQNMLVMVYDPASGQYVQKMMPMQLDPTTGNYVPAQAQTAAAPTTTKAQEREAEKQRKAAEKAEKERQAEERRKHADELREERAARARKNDSLLGRVQNTAISTATREVTRQVTRGILGGITGLFGGNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IES6</accession>
    <name>R7IES6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49823">
        <property type="protein sequence ID" value="CDE49823"/>
        <property type="gene ID" value="BN770_02150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="92" mass="9720" checksum="BA44103ABF48CF79" modified="2013-07-24" version="1">MEALTGFAVLSLLSSLLLSLLPETRLKSTVHLVASLLLLLSWLTALQTLCTRFSQPESSASAASPLSETADFSFADAVDALSRQPSAQEDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEV7</accession>
    <name>R7IEV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49981">
        <property type="protein sequence ID" value="CDE49981"/>
        <property type="gene ID" value="BN770_02213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="196" mass="21722" checksum="596B03F818380100" modified="2013-07-24" version="1">MSLGEVGPLRLSDVDWKRGTIDISHALKYTPQTGSFEGPPKSEAGERIIALPVGMMAVLDQTRAYQEDCKRAAPHLWVGEGWIVHAWNGAQLHHDTPSRWFRHFADAHGFEGVRFHDLRHTHASTLLANGIDAVAVASRMGHEDASTTLRVYAHALRRRDDDAARVWQSFLDAAFAQPKTPEPVENDGFAPSPDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF16</accession>
    <name>R7IF16_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Maltose/maltodextrin transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_02360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50394">
        <property type="protein sequence ID" value="CDE50394"/>
        <property type="gene ID" value="BN770_02360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030156">
        <property type="entry name" value="MalF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47314:SF1">
        <property type="entry name" value="PTHR47314:SF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="235"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE50394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="485" mass="54810" checksum="2C2CDDC3DDC87B60" modified="2013-07-24" version="1">MSQTKARKKPGVVRFFEGIAEFFISTVKAFVEGDIFVKLSALLCGTSCFARKQYLKGFFICLIQAAIMLVFPTFFFPYMSKLSTLGTVQQKRVFNPETMKNEFNDYDNSFLILLFGVLGVVLLIAAVILWMRNLRNAREVELTAKSGKHVNTFRDDLNDALDRKFHRTLLTLPVLGVVLFTIIPLIVMILIGFTNYDRNHLPPSKLFTWVGLDNFTRLTALTADSSFGYAFTRVLVWTLVWAVLATFTCYIGGILMAMFINNRNTKGKKFWRTCFMVAMAVPQFVSLLLVRNFFADLGIVNTICKNIGLTDWLYSIGAIPTANFIPFLTHPAWARPMIILINIWVGIPYQMLIATGILMNIPTELIEAAKIDGANAWQSFKSITMPYILFITGPSLVNSLVANINNFNVIWLLSRDVYTTSDQLMANANANEVDLLVTWLYRLTQDQSNYKMASVIGILVFVVCAILTLVAFSRMIKGDKEESFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFE2</accession>
    <name>R7IFE2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50058">
        <property type="protein sequence ID" value="CDE50058"/>
        <property type="gene ID" value="BN770_02259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="95" mass="11055" checksum="BF0CC427093784B4" modified="2013-07-24" version="1">METCCEYTDSVMWVSTDERRMITRMMKLIAEHPDETEIIKRPEENDGCLYCKVPSTWLKIAPPVKREMSDEQKAAASQRMQKLNEQARLSKTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFI3</accession>
    <name>R7IFI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49322">
        <property type="protein sequence ID" value="CDE49322"/>
        <property type="gene ID" value="BN770_01971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="270" mass="29028" checksum="C5B773F32A496D38" modified="2013-07-24" version="1">MSETKKKTAAPKPVSKKPYLTGKPLDSSCIGGAMRFFLYLLMMAIAFLFLGAVLSFDSFTLRLIINLAVVLLLLTVMFQSGAAAGSVAVNAGELAYQRKESNRMLNDAEIRACYHPLKGFLTALIGSLPLLIAATVLACTTQRQMTSIGALPTWVSSMMDNVDNGAALAVYAQDGGVAGMTILRIVIRTCILPAVNIVGATNSDAMLRLEQFSPLLCCLPMIAYGLGYPQGVRIRTQVQADIAAGKRKARKKANKERKQRAAQNGPEQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFT6</accession>
    <name>R7IFT6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truB</name>
        <name evidence="7" type="ORF">BN770_02415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50485">
        <property type="protein sequence ID" value="CDE50485"/>
        <property type="gene ID" value="BN770_02415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="172"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="33728" checksum="31DC5EF0400CC8DB" modified="2013-07-24" version="1">MNGFLNILKPPGMTSAAVVGYVRRMTGEKRVGHAGTLDPEAAGVLPIMIGRAARLFDYLVDKEKTYVAECAFGAATDTQDATGRIIATGENYPDFSAVQEAAEHLVGDIEQRPSIFSAIKQDGKPLYERARDGEDVEAPVRIVHVESIELHEETPDHGVRMTIRCGRGTYIRSICDDLGKLTGCPAHMRFLLRAQSGVFTLDSAMTMEEAAAYQAQGTLQSHLLPLDYGIQHMPRADAPEWLRKQVCNGVKLPAKKLPGVLALPEGQVTRVYLRDEFWGMAAREGEFLVWKCLLPPEKEENNANHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGB6</accession>
    <name>R7IGB6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50358">
        <property type="protein sequence ID" value="CDE50358"/>
        <property type="gene ID" value="BN770_00173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="299" mass="33027" checksum="E03BD316F5285514" modified="2013-07-24" version="1">MTLIYPATADAFRCIADACRHTCCKGWEIDIDPDTRAKYAAMTGEIGQRLRDAIADTPDGASFRLREDERCPMLNDSGLCDIITACGEGALCQICADHPRYRNEFSTFTEVGFGLCCEAAADLTLHWSQPMTWHTQGGGTRPQGSPEEEALLQARAALIRIMQDRTRGIPARLNALCEAAGTVMPTRTAAEWADFLRTLERLDPTWDAVLTRLTNVPDDLPDFSPLAVEQFTVYLLHRHVPGALLDGDLPGRVLFCAVSGMLFLRLSALLGENEAARMYSSEIEYSEENLCSFLDELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGL9</accession>
    <name>R7IGL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized proteins involved in stress response homologs of TerZ and putative cAMP-binding protein CABP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAPAB/TerDEXZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50611">
        <property type="protein sequence ID" value="CDE50611"/>
        <property type="gene ID" value="BN770_02458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="3">
        <location>
            <begin position="114"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="297" mass="33360" checksum="D49C908EA72D67E0" modified="2013-07-24" version="1">MAYAERIHPPLSRNMLTEELNRIRPALSRDSQPDMRESVMPALSDRLLNAPEATSAPQHHQAQTIPPRPPMPEHPTMRMVQPPMPNRTPAPTLQVPSQPMRPTVQPTPRRMPPMLMPVARGQKTALRLQERGCTRIRFGFGWHTNDSRCDVDASAFLLGESGRVLSDEGFVFYGQQTSSDGSVRFQPNGADDRETITVDTARIDPRIRKIVFVLTIDEALTQKLHFGMLQNVYLRILDDRDGREILSYPLGNAFENVTSMTLGELYLHQGQWKFNPVGNGVHMDLAGQCALYGVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGR5</accession>
    <name>R7IGR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein LplC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50780">
        <property type="protein sequence ID" value="CDE50780"/>
        <property type="gene ID" value="BN770_00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="311" mass="34877" checksum="77B14833F272B08A" modified="2013-07-24" version="1">MAKKEAEVHGIRIKETRADRTFNVLNLIFWMIVLFITLYPLWLVLIASVSDPDAVLAGEVLFWPKGFSLMGYEAVFQHSELWQSYLNSIIYTVLGSALSVIVSLAAAYALSRKFAGKAFVNFLITFTMFFSGGLIPIFLNVRDLGLYDTRLVMILMNTVSVWNLMVARTYIQSSIPNELYEAAVMDGADHFTYFFRCVLPLSGTIIAVLSVYYGVARWNDYFTGLVFIRNRAYLPLQTVLREILASLSISGSSDTFFAAYADNLGGLQEAMRKAEVAKYCCIVVSTVPAIVLYIFMQKYFVKGVMIGSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGS8</accession>
    <name>R7IGS8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">BN770_02432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50543">
        <property type="protein sequence ID" value="CDE50543"/>
        <property type="gene ID" value="BN770_02432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="257" mass="28495" checksum="12072BB7FF4B51FE" modified="2013-07-24" version="1">MISLKNPEQIGKMRDAGALLYEVLCRLREAVQPGMSTAALDVYAEQLIRKNHAIPSFLHYEGYPASICASIDDAVVHGIPSEKQILREGQILSIDCGLVLDGWQADSAFTMGIGEISLEAQRLIDVTEQCFFAGARQAIAGKRLGDVGHAVQQVAESNGYGVIRDLTGHGIGHEMHEDPPVFNYGTPDRGLRLRKGMTIAIEPMISAGDWHITCDADQWCYRTRDRSLTSHYEHTIAINEDGLPEILTYPDFKWEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHM4</accession>
    <name>R7IHM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase family 28 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50803">
        <property type="protein sequence ID" value="CDE50803"/>
        <property type="gene ID" value="BN770_00206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="757" mass="84035" checksum="BF1E3BEB665CE97E" modified="2013-07-24" version="1">MKREEINIRDPFVLTRNGQYYLYGTRGATCWGPADGFDVYVSRDLENWDGPFECFHNDGTFWADRNYWAPEVHEYHGKLYMLASFKREDLCRGTAILTADDPLGPFVPHSDGRVTPSNWECLDGTLYVSPDDKPYLVFAHEWVQVGDGEICAMPLSSDLSRAIGEPKLLFHASEAEWARLVHHRSSGRDGYVTDGPSMWRTEDGTLLFLWASFSDEGYTEGVAVSDNGDITGHFTQVEPLFRRDGGHGMVFRALDGQLYLTLHSPNEHLKEHPCFIPLEEVAGRLTPKYTLPDWFAPLQSRLHKMADELSASLTGWHGSDATFRPEDFGRIPGEKATCAIQSAIDKAGEHGGTVRLSGGDYVSGTLILRSNVRLMVDSGSRLLASTDLADYPEQIARRLTVQDTNMGMNQSLIFAEGCENICICGGGELDGQGTRTNFPGDETCHGTPGRPFLMRIIDCRDVHVHDITLRSAACWMENYLNCDRVLLERVTVRNQTNYNNDGIDIDGCRDVIIRNCDVESGDDACCFKGASERNTERVLIENCRLYSCCNALKVGTDTQGDFRDVLVRNCQIGGVEYDPSGLKHRCSDSGVSLEMVDGGTLENFLIENITIDRAWSPFFLRLEDRGRVKPGDPKPPVGTLRRIAISHVRGGDNGARGSYFIGIPEKAIEDVLLHDVVIAQHASEKAVLDEGAISELRGVYPDAHMIDDLGDAPARGLWARHVHGLSLAGYDVIPDKKDARPYLVAKTDVTMDKNACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHP4</accession>
    <name>R7IHP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51284">
        <property type="protein sequence ID" value="CDE51284"/>
        <property type="gene ID" value="BN770_00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06325">
        <property type="entry name" value="PBP1_ABC_unchar_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436629" evidence="1">
        <location>
            <begin position="24"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="315" mass="33231" checksum="2D3A58D8B94069BD" modified="2013-07-24" version="1">MKKMFAVLLALCMALTCLTMASAEEKTYHVGILQLVQHEALDAATKGFRDALTEKLGDKVVFDEQNASGDTASCAMIANGFVAAEVDLIMANATPALQAAVSATADIPILGTSISHYGTALEISDWKGYTEINVSGTSDLAPLDGQANMIVELFPEAKTVALLYCSAEANSAYQIGVVKAELEAKGITCKEYAFTDSNDVASMAQQATECDVLYIPTDNTAAAYSETIANVVVPAKVPVIAGEEGICRGCGAATLTISYYDLGYKTGEMAYEILVNGADVSTMPIAFAPQFTKKYNAAICEALGITVPDDYIPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7II51</accession>
    <name>R7II51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type uncharacterized transport system ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000207">
        <property type="protein sequence ID" value="CDE51275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51275">
        <property type="protein sequence ID" value="CDE51275"/>
        <property type="gene ID" value="BN770_00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="2"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="208" mass="23344" checksum="B792A197CA0EB2C0" modified="2013-07-24" version="1">MVDRGSIVIDGVDVTHLPEYKRAKYLGRVFQDPMNGTAATMNIEENLALAYRRGQGRTLRWGITAKERDEYREKLATLGLGLEERMSSKVGLLSGGQRQALTLLMATIKQPKLLLLDEHTAALDPKTAKNVLTLTQKIIAENHLTAMMVTHNMKDALEYGNRTIMMHEGKIILDIDAETKKRIHVEDLLVMFEKASGSEINNDRMLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIQ3</accession>
    <name>R7IIQ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
            <shortName evidence="9">ECF transporter T component EcfT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ecfT</name>
        <name evidence="10" type="ORF">BN770_00047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the energy-coupling factor EcfT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000213">
        <property type="protein sequence ID" value="CDE51336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51336">
        <property type="protein sequence ID" value="CDE51336"/>
        <property type="gene ID" value="BN770_00047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01461">
        <property type="entry name" value="EcfT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024919">
        <property type="entry name" value="EcfT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="30709" checksum="39B3DBC4BE9B0B7F" modified="2013-07-24" version="1">MNLNITMGQYYPVDSFVHRLDPRTKILLTILMIVAVFMVHSLVGYALVLAFLYWAAKCSNVPFKMLMKGIKPLRIILILTFVLNLFFSNGTTPLIDWWIIHITREGLTQAVHYSLRLVFLVLGTSLMTLTTSPIALSDGIELLLSPLKRFHFPAHELAMMMSIALRFIPTLMEEADKIMKAQMARGADFETGNLFARAKAMIPLLVPLFVSAFRRAGELAMAMEARCYHGGENRTRLRKLEITKNDYIAGGAVLTLMLLIVLEGVVVSHIGGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIS8</accession>
    <name>R7IIS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51366">
        <property type="protein sequence ID" value="CDE51366"/>
        <property type="gene ID" value="BN770_00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="428" mass="48684" checksum="9D72DEFB27768041" modified="2013-07-24" version="1">MDAAEQPRRFARLTGRKLAAVDGGSQRVLVQPGFNQLLHGVADHLAQLLLTAIGNVAQGQHHVRLRHRVVQRHAYILTLARRQQRLLQRRVVAARQHIKEDFRRRDAHRIRPRRNNLRQRQHGLVGSILLGADFIRLFRFSGEGLLHGNFVLLVQTVEAAQVLLRQRQHLVQRHSTIQINARIRRVIIAAVHAQELLVGQVGDVLRVAAGIPAVAVVREEDIQRLLVNLLVHIAHGALHLVEHNALVQRRAVFVQLNVPAFLIEDVRVLQDARREHSIQIHFRQVQEVLLVAAGDGVNRLVGEGHRVQERRHAALHQLDERFTDGILGATAEDRMFQNVEYTGRILRQGLKRDAERLVHLAVIHPNQLCAGLFVVHFHHLSVQLFAFTHTVNAKAVTRRSFVQIHHGDSFPCDPRRVIHFLYHSTTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIU5</accession>
    <name>R7IIU5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51386">
        <property type="protein sequence ID" value="CDE51386"/>
        <property type="gene ID" value="BN770_00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043723">
        <property type="entry name" value="DUF5665"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18910">
        <property type="entry name" value="DUF5665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="96" mass="10850" checksum="6583DF189FED2B07" modified="2013-07-24" version="1">MKEWAVWMANKMEEQLLRMEQLRLSEFVAYEKNWKKRLLMQFVGGIARGLGTAVGFTLLGALVVWLLQGLVQRNLPIIGDFLTQLLNLVEGKGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ09</accession>
    <name>R7IJ09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000223">
        <property type="protein sequence ID" value="CDE51471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51471">
        <property type="protein sequence ID" value="CDE51471"/>
        <property type="gene ID" value="BN770_00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="43" mass="5149" checksum="26021FF4435A99C3" modified="2013-07-24" version="1">MTNQRFDELLKQIKDYAEECNDAQKIIQYLDKLMEDVRSGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ61</accession>
    <name>R7IJ61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000213">
        <property type="protein sequence ID" value="CDE51333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51333">
        <property type="protein sequence ID" value="CDE51333"/>
        <property type="gene ID" value="BN770_00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42842">
        <property type="entry name" value="PTHR42842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="97"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="532" mass="57281" checksum="6744F9FA863C8F6B" modified="2013-07-24" version="1">MLRLDSLSLPLDFTPETLNALILRKLKCAPEQLKSVVPLKKAVDARDKADVHFVLSVAVTLKNEAKVLARLKPGSAAPFTFPKAPTLPKARFEHPPVVVGAGPAGLFAALTLARAGVQPILIERGKPVEERTKSVQMMQEQGILDPESNVQFGEGGAGAFSDGKLTTGTKSPLIRTVLQTFVDHGAPEDILYIAKPHVGTDLLKGVVRSMRQEIIQLGGQVRFDTRLTGLMMRGESMEGITVLCGGETQEIRTDTVILAIGHSARDTMQTLFRQGVRMEQKPFAMGVRIEHPQALISQSQYGKCWTHPALKAADYKLAVHTPDGRGTYTFCMCPGGEVIAAASQPDGLCVNGMSYHARAGENANSALLVGVRPEDFGDDHPLAGFVWQRSIEQAAFRLGGGGYKAPVQRVEDLLHDRATTRLGDVQPTYRPGVVPADLRACLPDFIIEDLKFGIRRMDGQLHGFAHPDALLTGVETRSSSPVRLPRSRETLMAERVDGLYPAGEGAGFAGGIVSAAVDGIQTAIAALHHHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ70</accession>
    <name>R7IJ70_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000226">
        <property type="protein sequence ID" value="CDE51531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51531">
        <property type="protein sequence ID" value="CDE51531"/>
        <property type="gene ID" value="BN770_00480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="232" mass="25210" checksum="A9A0930F9613D792" modified="2013-07-24" version="1">MPYYYYWDWTYLLIIPGLILGLIAQAKVKSAYAQCSRIPAKCGLTASQMVADLLRRNGNTRVRVGHVSGELTDHYDPSKEVLNLSDGVYSSNSIAAMGIAAHEAGHAMQKLENYAPLNLRSAIVPAVNICSSLSTPMFILGLIFAWQPLVYIGIGLFAASTVFALVTLPVEFDASKRAIQMLSEGGYISGAEEERNVRKVLSAAALTYVAAAVTSLLSLLRLILIAKRNDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJE8</accession>
    <name>R7IJE8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">F-type ATPase subunit c</fullName>
            <shortName evidence="12">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">atpE</name>
        <name evidence="15" type="ORF">BN770_00438</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51438">
        <property type="protein sequence ID" value="CDE51438"/>
        <property type="gene ID" value="BN770_00438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448340" description="ATP synthase subunit c" evidence="13">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="12">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE51438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="110" mass="10940" checksum="F9DB64DB8B9EA120" modified="2013-07-24" version="1">MKKFASVLVLALMAVLMLSVFAPALAEEAAAAATDSAIPAKAIAAAIAIAAAAGAGAIAMGISIGKATEAISRQPEATDSIRGSLMIGLVFIETAIIYALIVAILVVFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJN1</accession>
    <name>R7IJN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC-type sugar transport system periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50782">
        <property type="protein sequence ID" value="CDE50782"/>
        <property type="gene ID" value="BN770_00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436691" evidence="1">
        <location>
            <begin position="24"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="501" mass="56583" checksum="2B1F9E79F4260B8F" modified="2013-07-24" version="1">MKKIVSVLLALAMLLTLVGSAVAEDKVNLTAFQYTLENQSTDFNNLWFFQQIEEKTNTHVDFTMVKDADFQTQLNLMFISGKYMDMILRGSTDIEDYGVNQSLLMPLDEYITEEIMPNYVSRLNLNNAGDSIPASDGHSYYIGYLIAQNVNHNGTWYINTTLLDQLGLEVPTTIDEYTNVLRKFKEAGIKYPLSTSTFGYGPETIWNEFASFGVPENYAFYHITDDDKVEFTGTMPGWRACVEWLHMLYEEGLLDPECLTQDSNLWANKVNAGEVASFPYLRLINTALTPDVYKDFKSILPPADPTYGAAVSAILEVPEQGAILTSTNANPVASLKWIDAQLETETMMVAANGKVGEQIQLNDEGKYEVINVPENNGLYSFVPVTMGQFFAPGEYYTQIYQMAPHRVERYLDSEMYAAAGVLEHKSYQYVSKLSKMDNEDAVEAANIYTELKKFMEESVTDFIKNGVTDESYNTFVETAKAIGVERYIELYQNAYDAYLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJN8</accession>
    <name>R7IJN8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51686">
        <property type="protein sequence ID" value="CDE51686"/>
        <property type="gene ID" value="BN770_00567"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045330">
        <property type="term" value="F:aspartyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35951" checksum="B8042B9231A39660" modified="2013-07-24" version="1">MMLIQVAPGQSLQTVIDALPADDQPVTIHLAPGVYEEKIALRRPHTRIEGESAETTRITWHDGAAEILPDGKKRGTFRTATLLINARDCALRNVTVENSAYPREQVGQALALYVDGDGFHCEDCTLKSCQDTLFTAPLPPREIQKDGFIGPTQFLPRIPQRQVYRHCRIEGDVDFIFGGAAAWFEDCDIVSIDGLRDHGDRKEPALGFCTAASTPEGQEFGYVFMKCRFQGEGVPDGAIYLGRPWREFAKTVLLHCELGAHIRPEGWHDWNKPCFPATGYYAEFASTGAGSQGQRAAYVHRLTAEEAEKYTFERFWASISPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKG3</accession>
    <name>R7IKG3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000192">
        <property type="protein sequence ID" value="CDE51112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51112">
        <property type="protein sequence ID" value="CDE51112"/>
        <property type="gene ID" value="BN770_00288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="9">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="7">
        <location>
            <begin position="166"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="8">
        <location>
            <begin position="250"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="10">
        <location>
            <begin position="558"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="642" mass="73252" checksum="A64C27EB2FC5AEE3" modified="2013-07-24" version="1">MRHIIELKDGWQFTNLDGQTSEVSIPHTWNAIDGQDGGDDYKRGTCTYTLTLPKPAFDPDTQEVWIEFDGVNASAQVSLNGQDVCSHDGGYSTFRANLTGLLADENELVVKADNSKNDRVYPQMADFTFYGGIYRMVRLLVVNKAHFALDYLGSSGIRVTATPEGAGAKVRVQSRVTTGDVTVTVIDRKGRVVGTGTGLDTTIEMAKARRWHGVEDPYLYTARCEVTVDGSVTDRLEIPFGVRSFRVDEKHGFILNDEPYDLHGVSRHQDRKGIGNAITREMHDEDMALIREIGATTLRLAHYQHDQYFYDLCDRNGLIVWAEIPYISKHMPNGRANTISQMEELIEQNYNHASIVCWGVSNEITIATKDKQDMLDNHRLLNDMIHQTDPTRFTTLACYAMCGPFNKVAHITDVVSWNLYLGWYVPGLFLNDLWIGFWHLCYPKRLLGYSEYGAEGMPNLHSDHPRRNDHTEEYQAVYHEYMLRCFRRHPWMWANHVWNMFDFAADARDQGGEPGMNHKGLVTFDRKTKKDSFYLYKAWWSSDRFVHICSKRFVDRCGKKTTIKVYSTDDTVTLMVNGKTVGKKTSSDHVFTFTVPLDGDLDVEAFSGLKKDTAHFHKVDKPNPAYKLVKNKNAQKSNWVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKM6</accession>
    <name>R7IKM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000198">
        <property type="protein sequence ID" value="CDE51167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51167">
        <property type="protein sequence ID" value="CDE51167"/>
        <property type="gene ID" value="BN770_00310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010178">
        <property type="entry name" value="Integral_membrane_1906"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07314">
        <property type="entry name" value="DUF1461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01906">
        <property type="entry name" value="integ_TIGR01906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="217" mass="24592" checksum="F1AE5F4B6EF2F3DB" modified="2013-07-24" version="1">MRYQLVSILSALLLCLTMLAAIVYGVGTQPALMQTLMLRTAPPEATGFPAEQYGAAAKLITDYLKGEGDFQLVFSMNGIAYNAFNEREQTHMADVRTLFSLCRRFSLGSILLTLVGWLYSRKQRFFWRIVRRAACCMLAFVAILALLAAMDFDRLFILFHQIAFTNNLWLLNPQTDLLIRLMPTQLFIDYAQIIGIVWAALMGILLIIATVKLRNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKN7</accession>
    <name>R7IKN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000199">
        <property type="protein sequence ID" value="CDE51177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51177">
        <property type="protein sequence ID" value="CDE51177"/>
        <property type="gene ID" value="BN770_00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="133"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="276" mass="29036" checksum="E2FF7A4E46C66B90" modified="2013-07-24" version="1">MDGKYGAATTAAVVAFQSAQGLRVDGKAGPATQRALFTTSSSTDTSKYTTLRPGDSGAAIRQLQTTLKQKGYYTGTIDGDYGSGTTAAVKAFQKKMNITPVDGIAGDKTLTLLYSSDAVDSDEYATLRPGDTGAAVRTMQATLYELGYYDGSRDGVYGATTQDAVRAFQIRNKVTPVDGIAGNKTLTKLYSGTAVAAAAKTTEYKTLRKGDRGDEVVQMQDSLQQLGYLATVTGYYDDATVAAVRSFQSRNGLSVDGSAGQETLAVLYGSNPRAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKU5</accession>
    <name>R7IKU5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">BN770_00700</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51933">
        <property type="protein sequence ID" value="CDE51933"/>
        <property type="gene ID" value="BN770_00700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE51933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="288" mass="31204" checksum="DA9BC8F881D51D1F" modified="2013-07-24" version="1">MNILQAAILGLVQGLGEFLPISSSGHLLLSRILMGFTIDETGAYHMLDILLHVGTLIPVLIVFWKDWWAILKNPFKSKTLLLLFIASLPTLLFKVVFDDFITSCETGWFLGASFLQTGFFLLLAETLSAHRKQYADQPNFKHAIIMGCMQGVALLPGVSRSGSTLAGGLLSGLNRKSAAKFSFMMSAPAIVGALIIDGKTAIEEGWVQDLALVPTLVGILVAAISGYIAIRFMLSLISRVSLNWFALYVAILGVLILVLQLIGYPGTVPFAIPDMSGAVTSTLRFWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL05</accession>
    <name>R7IL05_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proton_antipo_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000254">
        <property type="protein sequence ID" value="CDE52003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52003">
        <property type="protein sequence ID" value="CDE52003"/>
        <property type="gene ID" value="BN770_00741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="48"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE52003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="414" mass="44130" checksum="3942EB3EAB8BB8F1" modified="2013-07-24" version="1">MCFCVLMAFVWTAAGFYSFDYMAHEGHEKRFYCLYLLTLGVLMGLCMSGSLVTFYMFYEAMTLLTMPLVMHSGSKEAVAAGIKYLIYSVIGASLVLLGIFAIAPYAQSLSFAPGGVLDMAKVAGHEGFVLAIGGVMLLGFGAKAGLYPLHGWLPTAHPAAPSPASAVLSGVITKAGVLGLLRVIYCFLGAQNLRGTWVQTVLMALSLLTVFIGSLLAYREHHLKKRLAWSTVSQVSYVVFGLSTLHPLGLLGAMLHVVCHSLVKDVLFMGAGAVILKTGETQVDALRGIGKRMPVTMWCFAIGSLGLIGIPPCLGFFSKWELAQGSLAMTGVASWLNWFGPVVLLLSALLTAGYLMPIVLRGFFPGKDAQVGEKCEASASMLIPMLVLTVLSVALGMFPSLLTDLLSPILTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL19</accession>
    <name>R7IL19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-glucosidase-related glycosidases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51302">
        <property type="protein sequence ID" value="CDE51302"/>
        <property type="gene ID" value="BN770_00369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="75" mass="8469" checksum="99C33394F68146C7" modified="2013-07-24" version="1">MFRSKRPVSPQIAWYVVAFCIVTVIVNSINCIWVDVAGQWVAPWLYNIGTTVLNGGVSMVVFFFVNKIIFRSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILT6</accession>
    <name>R7ILT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FtsK/SpoIIIE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51597">
        <property type="protein sequence ID" value="CDE51597"/>
        <property type="gene ID" value="BN770_00512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="712"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="729"/>
            <end position="736"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116561" checksum="7F1F8FFE420D5F47" modified="2013-07-24" version="1">MAQSKKNGKTNRTGRTAKQKRMPRYEADSLAACLMVGILLLATGILTLLGAGFGLQHEVFRYLRQFSSSMFGSMTLLMTFALIAAGVAMLISTTRKVSRRYVASYAILVVLLSGFVSLMTFVTSSEGQFPLLDYIAQKTGSDAFSGMMSRSMTYGMKGYGGGMVGMLLAWPLWKFFGAGLGAVILGLLMAVDVLVGGWSLFRRLYGWTGEKLVQLREKQAKRAEEAAAEEARRQEQERQRQLAEEQERIRQGNAANAAYTQNTPSPYARPGTEKGRVVSPYTQYPNAPVQPVMPQNPPVRKQPMPQGKPVQPVTSRKNNKIGFAPSAEELGQTGFADDWTTPRRKSAWSDSQPFTQPTYPMGQAAAEPPQIPTYEQPKQPAPSGVGDPATYSWNDMPAQPAPMQQTADAVPETEQNPPMMQWTQPTMPTKPTMAVDAPQETQEMQGEILPEAPEETPADLPEAMSADEVFDDDADFPAELDDRPPWEEPEDAPKKVVAPVLTQERPAGAWQPDLNLPAQPVSSGTTNVPVALQQPENIPAAVQPGIQVAKATTEAPSGGPSATGASATSTFNPEVPYTYPPMMLLRDPLGQQGVNAEEDELRTQRLEETLKSFRIPAKVRHITHGPAISRFELEIAPGIKVNKVTNLNHNIAMNMAVKSVRIEAPIPGKALVGVEVPNSTRTTVTLKEVLQSDVMHKAKGPLTVALGKDIAGAPILCNLAKMPHLLIAGATGSGKSVCINTIINSLLYRCSPKEVRMILVDPKVVELQCYNGIPHLLIPVVSDPHKASGALAWAVGEMMDRYNKFQEKGVRAIDGYNEALDEDEEPMPRIVIVIDELADLMMTCKKEVEERICRLAQLARAAGIHLVVATQRPSVDVITGLIKANIPSRIAFKVSSNVDSRTILDRNGAEQLLGYGDMLYMPMGEFTPIRVQGCFLTDDEVNGITDFIRQYSPANYDSGVLDELDRLANMGNDGDEDDPDANSTVDEYSSADRDLFSQCVEMAVRDREVSTSLIQRRLKLGYARAGRLVDEMEQRGIISAKDGAKPRRCLISMEQYEAMKASGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IML0</accession>
    <name>R7IML0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51857">
        <property type="protein sequence ID" value="CDE51857"/>
        <property type="gene ID" value="BN770_00656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025364">
        <property type="entry name" value="DUF4268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14088">
        <property type="entry name" value="DUF4268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4268" evidence="1">
        <location>
            <begin position="173"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="308" mass="35742" checksum="922EE73B3130B46D" modified="2013-07-24" version="1">MEQLEVLTEVQDLRKVWPHEALDFTPWLAKDENIAILGNEIGMEIAVDGTESAVGDFSVDIIATDIATGQKVIIENQLEDTNHDHLGKLITYAAGKDAQTIIWVVKHAREEHRAAIEWLNNHTDDDIGFFLCEIHLYKVGSSNPAVKFSVIEKPNDWIKSVKKNQQQTESQQFRLDYWTAFNEYAYANAQFARQFGKRKASNKMWMNLSIGSSVYDICLRAVKTENLLVVELYIRGDKDLYHQLFEKQNAIEQELGVALDWRELPEKKASRIMLTRQVDFDNRSAWNAQFDWMMEMSLKFKKVFKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IN13</accession>
    <name>R7IN13_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000255">
        <property type="protein sequence ID" value="CDE52022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52022">
        <property type="protein sequence ID" value="CDE52022"/>
        <property type="gene ID" value="BN770_00753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448447" description="TPM_phosphatase domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE52022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="30103" checksum="4E3A6788EE1A23B9" modified="2013-07-24" version="1">MVKKLTLFLLLMMLTLTVALADTQVQDDAGLFTADEIAEISAICDRIESAYQVDMFVLTSQDVPSGQTTAYADDYFDYNGLGMGDDRAGMLYLIDMHNRQCWISTRGVMIDYITDEREEGILDAGWDEMLDKEYGQSVIKVLKQTEKYLKQGRTSGQFRYDEVTGSRLTEFYEPENTLTGMEILIAVIAGLAVMGIFIASVSGKYNLKGSTYSYDLNGLASVKLSRNDSHFVREHVTRVKHPDPPSSSHGGSSHGSGTHVSSSGATHGGGGRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I324</accession>
    <name>R7I324_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ORF">BN770_00818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46269">
        <property type="protein sequence ID" value="CDE46269"/>
        <property type="gene ID" value="BN770_00818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="96" mass="11023" checksum="120A5799D4A687C6" modified="2013-07-24" version="1">MLVLITYDVSTVDADGKRRLRQVAKRCVVHGQRVQNSVFECSLDAAQYKLLQAELRQLIDPEKDSLRFYNLGNHYESRIEHIGVKTSYAPEGLLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3A5</accession>
    <name>R7I3A5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46369">
        <property type="protein sequence ID" value="CDE46369"/>
        <property type="gene ID" value="BN770_00850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="82" mass="9249" checksum="FCA4EEBEF8F8EEEC" modified="2013-07-24" version="1">MTDASPYWADFRKGTEAIRRDEENGSDPAKLGRRVAELLTREKLPFRKKIGSPAQMLAPALHKVLPGRAMNRILRQYTLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3H0</accession>
    <name>R7I3H0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46449">
        <property type="protein sequence ID" value="CDE46449"/>
        <property type="gene ID" value="BN770_00867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="194" mass="21460" checksum="5677E5813656C86F" modified="2013-07-24" version="1">MQWLVGLPCKVQGFCHEGKWHNIEVEDDVTAYFEYPNGATGVFITTTADAPGTNRLEITGTKATLICQDGKLIMKKLEMDEREWCATCREGFRAPSYETMEVETDGQNGQHPAVLNAFAAHILRGEPLVADGREGINGLMLSNAIHLSSWLGHPVTLPIDEELFLEKLNERRATSRVKTGESVFSDTNGTYGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3S4</accession>
    <name>R7I3S4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000002">
        <property type="protein sequence ID" value="CDE46136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46136">
        <property type="protein sequence ID" value="CDE46136"/>
        <property type="gene ID" value="BN770_00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="2">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="122" mass="14126" checksum="B6C893D23E8AD06A" modified="2013-07-24" version="1">MDATVNWPNLDFKFKNDTEWPIYIVANYSKQKCTVEIYGMLLPDGVSIDLESTVTRTIDPPSDTKYVQNTKLAAGTQETTIKKRTGYVVETYQIWYQNGKEVDRKLLCTSTYKAYQETVEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I412</accession>
    <name>R7I412_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000021">
        <property type="protein sequence ID" value="CDE46634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46634">
        <property type="protein sequence ID" value="CDE46634"/>
        <property type="gene ID" value="BN770_00967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_EFTU_D2" evidence="7">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="GTP_EFTU_D3" evidence="6">
        <location>
            <begin position="120"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="216" mass="23834" checksum="5F92AAEFD6005EAA" modified="2013-07-24" version="1">MDNAPECKCIWELMDAVDHYIPEPKRATDQPFLMPVEDVFSISGRGTVATGRVERGTVKVSDTVEIVGLMDKPKSTVVTGVEMFHKLLDQAEAGDNIGALLRGIQRNEIERGQVLAKPGTIHPHTHFIGQVYVLTKEEGGRHTPFFNGYRPQFYFRTTDVTGNIKLPEGTEMVMPGDNIDMEITLITPIALEQGLRFAIREGGRTVGSGVVAKVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4B0</accession>
    <name>R7I4B0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Germination protease</fullName>
            <ecNumber evidence="1">3.4.24.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GPR endopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Germination proteinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Spore protease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpr</name>
        <name evidence="2" type="ORF">BN770_00820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Initiates the rapid degradation of small, acid-soluble proteins during spore germination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase action with P4 Glu or Asp, P1 preferably Glu &gt; Asp, P1' hydrophobic and P2' Ala.</text>
            <dbReference type="EC" id="3.4.24.78"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.78" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000006">
        <property type="protein sequence ID" value="CDE46291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46291">
        <property type="protein sequence ID" value="CDE46291"/>
        <property type="gene ID" value="BN770_00820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00626">
        <property type="entry name" value="Germination_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005080">
        <property type="entry name" value="Peptidase_A25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03418">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023300974" description="Germination protease" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_5009019667" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="292" mass="31432" checksum="FFA4FB8E2049B59F" modified="2013-07-24" version="1">MDYRTDLAMERTVRPGGMGEGVSVHTQQQAGAEVTWVRVSSEKAAERLGKAQGLYWTLTHPKLPHMLPEERMDIAREVAQMLRMMLPPQGDVLVLGLGNRRMTADALGDRVVSGILVTRHMQEERLRSVCAVAPGVLGITGVETAELALGLAERVKPSAVIVVDALAAMETNHIGTTIQLTDTGIRPGSGVGNHRKGITAETMHVPVIAVGIPLVVYASTIVRDALADMMQRESGDAQALAEQLTSGYPRDFVVTPRNIDELVAGLADLLALAINSALQTNLEMEELSHCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4F8</accession>
    <name>R7I4F8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46535">
        <property type="protein sequence ID" value="CDE46535"/>
        <property type="gene ID" value="BN770_00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="180"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="243" mass="26432" checksum="C0F7E8C3302C4E00" modified="2013-07-24" version="1">MRLLRFFAPQTAFSHRLNRGENMTIDEFLTNVRRIQAADPRYRLGRDGSDGYCDCIGLVIGAIRRSGGQWRGIHGTNWTARNAMHDLNPLRGAGQLRRGELVFRAHEPGAKGYALPSRYASSADRRDYYHVGVVMQTNPLRILHCSGGGVKADTSATRWQFHGMLTMFAGRMGLMQIGDSGDAVKGLQSALMAAGFPLPLHGADGNFGAETEQALRQFQQKSGLSASGAADAETLAALRLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4H4</accession>
    <name>R7I4H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46749">
        <property type="protein sequence ID" value="CDE46749"/>
        <property type="gene ID" value="BN770_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447964" evidence="2">
        <location>
            <begin position="23"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="807" mass="90666" checksum="2D935F31C9FE668E" modified="2013-07-24" version="1">MKFRKMASVLLAASLLIGCAAAENRTIFKRMSEEESMANEALPVEERAESFSPAGLLSLNDRVAILMQEQTSRLYSLYTWQPGQQEMALVASNMYRAGDYGQLKDLQERLENLKEDALAGTELPDAAHCFSMLVTDGEKVYGINHLTGGIFTISGENGKAVYTDVATVQDTKFFIQEEEDYSYALLPDTVAASGNTVLMLMNTWDDKGRVTNLYALSLTDGSVRKASVENVRNFCAYKDGKFLVIALQKREDWDENGNRIPQMAMVYDPATDTTTMLSSSIGVRDDFSYQQLVYSEALDAVLYCDSTQIMGTTNFQKATLYAYLPVEGYYVAIVGDTIVSAGYSSGIFARTLTENYQPNHVIHLSGTSVWGGIHDYAVDYPEVAVVGDSDIDSASAEEVARAFASGDDAPDIVSAYVNSYTSCDAAGGLAIERLNQKGYCKDLSVYPAVKAYVESLNPVFRDFVTDANGKIFALPISVGGAYAFTINPKVFEEMGLTMDDIPTNFIDLCAFVTRWNDEFVEDYPNFAPLDSTEKYKDRMFRLALREWKGYCQATNQDLHFDDPIFREMVAAIDAMRCDRIEESNKKTSDEESDYKQPLIFTGTWMLNSYYDGDVTFGKDKMPKLIQMTLTKDTAFYLGQGIEIELMFVNPRTTDSDEIGTLLEYVIKNIRDEQKVELVAGCTTPIENPWYEEQRKQDEAELVMYQKAYDEASAEEKNAYKEQLDEFKLYMEQSAESDRYTVSPAYIQRYQDVILPALYIGKPTVLDSTDNTSGLKTLVQRYIDGQITIDQFIREADGKLRMIQLENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4K7</accession>
    <name>R7I4K7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fumarate hydratase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000014">
        <property type="protein sequence ID" value="CDE46416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46416">
        <property type="protein sequence ID" value="CDE46416"/>
        <property type="gene ID" value="BN770_00856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="279" mass="29457" checksum="824A7983FC182454" modified="2013-07-24" version="1">MKTVNAQTITETIAHLCIDANRNLPRDVATALHQAEETEPFAPAKDLLSLLTKNEQIARTTQMPICQDTGMAVVFADVGQDVHIAGDFAEAVNEGVRRGYVEGLLRKSVVGDPLRRVNTGDNTPAVLHTRLVPGDTLTLTVAPKGFGSENMSQLRMLTPASGIDGVKRFVLDTVRAAGANPCPPMVLGIGIGGDFEQVAENAKRALMLPLGTPNPDPFYAQLEAELLEAINQTGIGVQGLGGRTTCLGLHIIAAPTHIAGLPVAVNVSCHVTRHATAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4P0</accession>
    <name>R7I4P0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46451">
        <property type="protein sequence ID" value="CDE46451"/>
        <property type="gene ID" value="BN770_00869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="12"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="393" mass="45019" checksum="DD18605375EC7B40" modified="2013-07-24" version="1">MTAYRPNCRRIPELNGLRVLLVFIVSWYHFWQQSWLTPSIGRYSLDYLLRAGYMPVDGTILLSGFLLFLPYARTMMLGERVPDTKAFYQRRIMRIVPSYYFLTLLMLVAVAIPYNLYGRTSEAVRDVLMHLTFTQTFNYATYIATPIGVASWTIAIEMQAYLIFPLLAKGAMKNPLGTLMSMAAVAFAFRGWCLWRLDEYNMVVNQLANFLDVYAMGMGASILYVRLTQLYPAESRRKWLWQGAATLVFCVSLYGMLRVIRAQAYTSGQAAMQAAQMMRRPLLCLTITGLMLSLPFAVRPLRFLMGNRVMGWLAAISMNYYLLHQNLAVHLKRLHIPPSVSNEPNRVGEQPWQNQYMALCFGLSLLGAILITLLIEKPCAWALKKLFTRKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4T1</accession>
    <name>R7I4T1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma-24 subunit ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46501">
        <property type="protein sequence ID" value="CDE46501"/>
        <property type="gene ID" value="BN770_00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="163" mass="19384" checksum="B88632A0992E16B9" modified="2013-07-24" version="1">MTQTEFTQRVLTMQDRLYRVSCTLLRCEADREDAVQSALEKAWRGRFLLRQEQYMETWLTRILINECYAIMRRSRRIIPMAEVGENQPAQWEAQNADEMLCRALTALPDTLRLPIVLHYMEGMDIRTIARTLRIRESAVKSRLHRGREKLRQSDELKELVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Y8</accession>
    <name>R7I4Y8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000006">
        <property type="protein sequence ID" value="CDE46293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46293">
        <property type="protein sequence ID" value="CDE46293"/>
        <property type="gene ID" value="BN770_00821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="185" mass="20213" checksum="7F635346F9D57640" modified="2013-07-24" version="1">MLTHEMTIAGLKRALPICRVNDNLYIGAFVIFGDCELTMACATELLKKAPEYDYLITAESKGIPLAYEMARQHGDKKWLLARKGAKLYMQNVVGVEVKSITTAAVQKLYLDGEDAALMKGKRVLIVDDVISTGESLHALEALVNQAGGEIVGRMAILAEGDAQERTDLIYLEKLPVFNAKGEIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7I558</accession>
    <name>R7I558_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">BN770_01113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47019">
        <property type="protein sequence ID" value="CDE47019"/>
        <property type="gene ID" value="BN770_01113"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="156"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="404" mass="44390" checksum="54F855C3DE413D85" modified="2013-07-24" version="1">MAKVQLGVIFGSRSCEREVSIISAVQLMNHVDSEKYDVIPVYIGENGVWYTGNALRRIETYTPFDPNKAGIEAVALDVTAGSGALLANRPGKGLFSHPTQVMVARLEVCVIVMHGLNGEDGTLQGMLELANLPYTSTGVAGSAIGMDKIMMKQFFRGAGTLPCLPDCWFTRAMYQQDKNAVLDKVEKELGYPVFVKPANLGSSIGVSRADDREGLTDSLELAFEYDRRVLVEKGLDHPIELNCSVLGYDGDVEASPIEMPLSGQQFLDFKEKYLANGGSKGMASLHRVLPAPIEDSLRDKIQAMSCDIFRMLDCKGVVRIDYMFDRASEQVYITEINTIPGSLAFYLWENKGVKYSQLIDRMVDCARKAHEDRNMRNYAYSSDILKGVSLGGAKGAKGSKGSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5C2</accession>
    <name>R7I5C2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46820">
        <property type="protein sequence ID" value="CDE46820"/>
        <property type="gene ID" value="BN770_01036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="72" mass="8146" checksum="BCBB76C7571108FE" modified="2013-07-24" version="1">MVLRNRLKVYRAMLNVNQQEMGRLCGVSRQTISLIERGDYSPSVTLALTIAKVCGASVEEIFYLQEGTEHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5C5</accession>
    <name>R7I5C5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46691">
        <property type="protein sequence ID" value="CDE46691"/>
        <property type="gene ID" value="BN770_00995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="309" mass="33364" checksum="1951CADBADF3EF74" modified="2013-07-24" version="1">MSEKITAVQRRLLEEVADLHGVPEGAYNIRANGHLASRQTTANISIESKTDVSGIDIRIKPGTVNESVHIPVVLSESGLKEMVYNDFYIGEGSDVLIVAGCGIDNCGSQDSQHDGLHRFFVEKNAHVRYVEKHYGSGDGAGKRLLNPGTEVHLAQGSSMEMEMVQIRGVDSTIRTTTAELEAGARLVVRERLMTHGDQKAESIYVVTMKGAGSSADVVSRSVAKDNSWQKFDSRLVGQAACSGHTECDAIIMDHAKILAVPQLEADDLDAALIHEAAIGKIAGEQIIKLMTLGLTEQEAEEQIISGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5E2</accession>
    <name>R7I5E2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46478">
        <property type="protein sequence ID" value="CDE46478"/>
        <property type="gene ID" value="BN770_00890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="55" mass="6053" checksum="0F531643A8E4DC9D" modified="2013-07-24" version="1">MLIACEDKKMELEQGMTVEQCLIKLGVSREGVLAVQQGGRVLNIYAVSRQMGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5I9</accession>
    <name>R7I5I9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="7" type="ORF">BN770_00082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47144">
        <property type="protein sequence ID" value="CDE47144"/>
        <property type="gene ID" value="BN770_00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="44" mass="5330" checksum="43645853E203C427" modified="2013-07-24" version="1">MFRTYQPKKRQRSKVHGFRARMATKNGRRVLSARRRRGRKSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5K0</accession>
    <name>R7I5K0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="7" type="ORF">BN770_01074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46925">
        <property type="protein sequence ID" value="CDE46925"/>
        <property type="gene ID" value="BN770_01074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="277" mass="30371" checksum="8EBF61B38844E451" modified="2013-07-24" version="1">MKQKQTTPAEETEDKRPNETPDGDSSDGESSDGESSDGLKEAGESMLSHLMALRKVLLISAAAVLIGFVLVFYLAIDPLMAQILAPIQARGIQVIFTTMSEALVTKFKVALLAGMMIASPVVIWEIWGFIKPALYPQEKRKFRLLFVLALLLFLTGVVFCYFAVYSLAVDFFLVAGDSLATPMLSIDKYVSFLFGFLVPFGVAFQLPVVLYLTTRVGLTTPDMLRSKRKYVILAIFVLAAILTPPDVVSQVALGLPMCGLYEIGILVSRCTKARERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5R8</accession>
    <name>R7I5R8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000020">
        <property type="protein sequence ID" value="CDE46598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46598">
        <property type="protein sequence ID" value="CDE46598"/>
        <property type="gene ID" value="BN770_00958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="168" mass="18649" checksum="A910EC1AFEB6DB55" modified="2013-07-24" version="1">MPQKSIKAVMDELTAMAQDKNTSPRAFADSFQAHSAELRAVFFPDTPMKMPETHDDTEESSQECVTCFCEFLAKCTSADDQNCPVTIVVSAHELPTVSVQTISGAKVIFDDLYACRSMDEDTRGRFRELEALWGENSEDGCFVAKFCEKLKASLPAIFASTIEIKRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I638</accession>
    <name>R7I638_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000042">
        <property type="protein sequence ID" value="CDE47304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47304">
        <property type="protein sequence ID" value="CDE47304"/>
        <property type="gene ID" value="BN770_01205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="208" mass="22676" checksum="7AF4C45E64CFFEE4" modified="2013-07-24" version="1">MNILYILLALGIIGHAINMYCDRILSIFPNGTLKLANYSKLKEGDYAAKLMEGVSPSVPMRSGVLGVFAIVLEFCGYAALAAYAYQKAPVYGAILFAGTTFACIVSSAYHLKCGLAEYMFLKYGRDERAKGMMLDLMGSGASLRLCSLGMITFYITLMVAIITGAIGFPIWALVFTILPIFIVMFPLQIVGTLHIAAMMSMLGWMFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I649</accession>
    <name>R7I649_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M78 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000034">
        <property type="protein sequence ID" value="CDE47125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47125">
        <property type="protein sequence ID" value="CDE47125"/>
        <property type="gene ID" value="BN770_01151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="65"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="211" mass="23692" checksum="BEC5EDCA27AEC7C5" modified="2013-07-24" version="1">MQQNNGMSRAAAMAYRVLIRRGVSALPVHPLEILSACRNTVVWADVTAAEQLKIPREVLLRQLANAEAITFRQTIQGETRFIVVYREGGNPARLRFTLAHELGHRLLHRGDEPNMEREADCFASHLLCPRPTMGRLCTRENTFSVEQAAVLAYVSASALQRLSRVEELTVSPEILSAADDLLADWAQRVPLPPQRPGQHRLQIRTKFLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6F6</accession>
    <name>R7I6F6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clostripain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47071">
        <property type="protein sequence ID" value="CDE47071"/>
        <property type="gene ID" value="BN770_01127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005077">
        <property type="entry name" value="Peptidase_C11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37835">
        <property type="entry name" value="PTHR37835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03415">
        <property type="entry name" value="Peptidase_C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435520" evidence="1">
        <location>
            <begin position="24"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="674" mass="74547" checksum="84AE9FD08AFDEE30" modified="2013-07-24" version="1">MKHQLLALLLGSLLLLGLPAACADTPTITVLMYMCGTDLQSDCVNDLYEMCAADIPDNVTVVVQAGGASQWDDSRLRANHINRFTIADYDFSDVEVCAWQSMGAQNTLEDYLTWATSTYPADRYMLIFWNHGGGSTSGVCFDETADYDGLTIHEINDALYNFTEANPDFHLDLIGFDACLMATYEAAAHMQYYADFMVASEELEPSLGWNYAWLNALGENPALDAQGIGVAIADAYMEACMDENPDDYLSMSVLYLPAMDYLVSTMETYASYLSQALDAGQLSTFSRARQRMYAFGDFDSATSDMVDMMALIDGTRTIAPQTADVLQTAYERVVRYNVGTRKFDYLTGMSVYFPSGSYEGDGCQETIPRMTEFTRGYAELRSGGNYVFSAQVPQQVTTSSVFTGNLTDAFFSPASTFTTSETPLAVEADAVDLPDVVPTFTSMNDAFFTGSLIPDDSAMDDWLDMDDDSAYMCSMMLSQDELNNLSMVEGLLYLDGSDDEDTFYIEMGAMQNAAIDWESGEIISQFDGTWPMLDDQIVMMYDQLVNGGMRRSVIPVRCNDVEGYLLVIRRSYSSGWTIVGFTQGYDDAGLPVRGSTPLTEGDVVTPIYNVLYEDEDGELQEMTMDGDPIVAGKDGSIDFGFYSLEGSDATYLYCFCLTDIYGEIQLSDFINFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6G3</accession>
    <name>R7I6G3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">nnrE</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="18" type="ORF">BN770_01256</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47454">
        <property type="protein sequence ID" value="CDE47454"/>
        <property type="gene ID" value="BN770_01256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="9"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="413"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDE47454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="507" mass="52918" checksum="19B394C76D9BFA1E" modified="2013-07-24" version="1">MTTITPDEMKSLETLFMSETGTPSILLMEHAAQGVAAAVSRHAPKSARVLFLCGPGNNGGDGYAAARLWCSGGGQADVWEVTSAVRGDALTNRTLALLHGVRVLPSVDAVDVAEYAAVVDALYGTGLNHAIEGDAAILIHRLNDHPQIPVIAVDIPSGLDGTTGRALGADVVRAAETVTFHRIKQGLLLRQGVEYTGKITVQPILIRPGDDIDLGFDGLETLSPAALAPLFARTPALHKGDCGRAVIFCGSRGMVGAAAFCANACIRAGAGLTTLLCRESLLPMLQVLAPGATCVPLPETNGLLTPQAARITRETLDKADAACIGCGCGLTPDVTMLLRVFAEADCPIVWDADALTLLATHDGILPLKEEDIITPHPGEAARLLEQHVEFILDEPLDALSRLHDLCGCCVLLKGARTLVSDGDATYISLYGTPALAKGGSGDVLSGILTALLCQRNRLSTSLSTSALAAYGVLIHALAGLRAEKRFGANCSTPQALIDAIRLDDKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6L6</accession>
    <name>R7I6L6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47255">
        <property type="protein sequence ID" value="CDE47255"/>
        <property type="gene ID" value="BN770_01183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="4"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="384" mass="41140" checksum="A7137B3189DE914B" modified="2013-07-24" version="1">MKTIYLDNSATTKPSAAVIAAMTDALENGWYNPSALYRPAMDAEKAVENAREICLKAAGAANQRMVFTSGGTEADNIAILGHLRTKHKPGRVLMLSVEHPAVLNCAQEAERMGHKVVPIPVDRRGVVDLPALEGLLGEDVHLITLMQVNNEVGAVQPIAEVAALRDRFAPNAAIHVDGVQGFLRVPLNFNALKIQSYAFSGHKIHASKGIGGLIFRKDHKLSPIVFGGGQEDNLRSGTENVPGIIGLGEAVRTYPQGAAEKMMALKTRLLTDLQEAIPTAKRNGPALDDPLCAPHILSVSLSPVRSQTMLFALEGDGIYVSAGSACAAHKQKVSGVLTAMGLSPAEADCTLRFSLCPDNTEAEMDDVARCVKKHYDLLKAYVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6P1</accession>
    <name>R7I6P1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="8" type="ORF">BN770_00087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47151">
        <property type="protein sequence ID" value="CDE47151"/>
        <property type="gene ID" value="BN770_00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="87" mass="9393" checksum="59BCFA46C4CEED9D" modified="2013-07-24" version="1">MPNIKSAKKRVKVSEKKNLRNRMIKSAVRTSVKKLEAAIAADPQTANAQLVVTTSAIDKAASKGVMHKNAANRKKARLAKQLAKATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6P8</accession>
    <name>R7I6P8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46933">
        <property type="protein sequence ID" value="CDE46933"/>
        <property type="gene ID" value="BN770_01080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="331"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="461" mass="50464" checksum="22003BE754550169" modified="2013-07-24" version="1">MRNETVERIVNLLFQDVEMTDEVQALYDETMSNCQERYQDMTSRGLSDDDAIAAVVESLKGMEDVISQYPKKSEAPEAEEAPKSADVPGDDDGDGEQTDFTFHPADIGRIEMTMVCDDVHLEESPDDDLHVLFEDAEGAKASICRIEDGVLRVCRDPDAPKRNRSSFTVSGSFANGRLYVKKPNGEYFFFGDKKSDKQVEAEAERHAKEFEQHAKEFSDNMSKMGFKQESTGDGKNPNSIESMIDSFASTASRFGQELGKLFSSIKPNITVSRSIGDVTLCIPRSFDKPISVLTTSGDIEARDIHVTDLNFTSTSGDISVELFAPLNRGAFTTTSGDINIEADANDVQISTVSGDVEIHGDYDHLKFASTSGDVELEAKVRQCDFSSVSGDLDLRFTGALSLINGSTTSGDIDVELPDDTGMNNIDVHSRSGDISMRRSGRRGSRTVTGSIRSVSGDIEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6X9</accession>
    <name>R7I6X9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argB</name>
        <name evidence="9" type="ORF">BN770_01245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47400">
        <property type="protein sequence ID" value="CDE47400"/>
        <property type="gene ID" value="BN770_01245"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="298" mass="32197" checksum="049F5AF94BE6375D" modified="2013-07-24" version="1">MQMYNGMTNRQRAQVLVEALPYIQKYNGKIVVVKYGGNAMINEELKHDVMRDMVLMSLIGVKMVLVHGGGPEISSMLKRVGKETEFVNGLRVTDEETSEIVQMVLAGKINKSLVAKLDNLGGRAMGICGMDGGLIKAQMIDPKLGYVGKINSVNPQPILDLLEKGYIPVVSTIGCDETGHVYNINADTAAASIAAAMHAEALISMTDTVGLLRDPKDPTSLIRRVDLKGVEELKAEGIISGGMIPKVECCTNAIRAGVRKVFIIDGRVPHALLIETLTDEGAGTMFKKEIEGNYVPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7U4</accession>
    <name>R7I7U4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47571">
        <property type="protein sequence ID" value="CDE47571"/>
        <property type="gene ID" value="BN770_01287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="99" mass="11007" checksum="05362CDC4022C8AA" modified="2013-07-24" version="1">MVEHAYQELHTRGSFDPEVMSVVYLINAIGKPNGFQASLLAWIVTFSRHLLPRGPREQVYLVRNGEHTTMLTPVVGNEDGSAFAGSIFRRSVEVLAHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Y2</accession>
    <name>R7I7Y2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS</name>
        <name evidence="10" type="ORF">BN770_01228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47383">
        <property type="protein sequence ID" value="CDE47383"/>
        <property type="gene ID" value="BN770_01228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="9">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="617"/>
            <end position="624"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="868" mass="97769" checksum="50D3C4E612B3FD08" modified="2013-07-24" version="1">MASVTPMMQQYLDTKAEYKDCILFFRLGDFYEMFFDDARTASRELELTLTGKDCGLSERAPMCGVPYHAVDTYVEKLIERGYKVAICEQMEDPALAKGLVKRAVTRIITPGTVIEPAMLDEKANNFLLSICFVADRAGLAFADVSTGEFYVHEITQPETTLSDEVARISPMEIICNDQVKLRACLQREMQNASEQPSAWFQLANATEALCRHFALNDLSPLGLSDEYKAGASAAGALMRYLSETQKNALEHMTSLRIYQGSETMLLDRNTRRNLELTESIRGRSRKGSLLWLLDKTSTAMGGRLLRSWIEQPLVDEEKINRRLDAVGEFAQEHVLTMTLAEELQGVYDIERLLSKVAYKSMNARDCLSLCASLQKVPKIRELLREAKSQAVEEIRDSLDTLPELTDLLTRAIHPDAPILITEGGIIRDGYSQMLDEYRAASTSGKQWILELEQKEREETGIRNLRIQYNRVFGYYIEVSKSYYEMVPARYIRKQTLANCERYMTPELKEIEQKIVGAQEQSTRLELQLFTEVREKIAEQIARIQKTAMALKSLDALLSLAKSAIEYHYVRPEMTQDGTLDIVEGRHPVVEQTMSEGGFVPNDTHMNADDCRMCIITGPNMAGKSTYMRQVALIALMAHIGSFVPAKEAKIPVTDRIFTRVGASDDLASGQSTFMVEMSETAYILRNATAKSLVILDEIGRGTSTFDGLAIAWAVVEYLCDKQKSGAKTLFATHYHELSELEGHIDGVQNYCISVKEHGEDVIFLRKIIRGGADKSFGIHVARLAGVPHPVLVRAHEIQARLEVSDINQHGIGQNILGDAEKRKDEQVNLFDYRKTEIINELQTLDVMALTPMDAINKLFLLREKARKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I835</accession>
    <name>R7I835_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 8 (cellulase D) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46677">
        <property type="protein sequence ID" value="CDE46677"/>
        <property type="gene ID" value="BN770_00989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002037">
        <property type="entry name" value="Glyco_hydro_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01270">
        <property type="entry name" value="Glyco_hydro_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00735">
        <property type="entry name" value="GLHYDRLASE8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="388" mass="44075" checksum="0005D109C8A5C9DB" modified="2013-07-24" version="1">MSTYPNQFARIGISDAAVLSRLSDCFSTIFFSPENNFYHPHPTDPDAACMVDTGNNDARTEGMSYGMMMCVQMNRKDLFDKLWTFSMRYMHLSSGVHQGYFAWSVQLDGKHNAEGPAPDGEEYFAMALLMASARWGDGEGIFAYRHWAQDILRHCVHQAEMVEGGQPMWNPENHYIKFVPGMEISDPSYHLPHFYHLFAKFSDERDHAFWAEAEAASRRYIALCAHPVTGLSPEYAAYDGTPVLMFGKNYAYYSDAYRVIMNIALDTLWNGRTQSLCDIATHVQDFFAKELPEENYRAYDLDGTRWDEPAMHPVAITAVNAAGSIASDSETADMWLKRFWELPMRTGKRRYYDNRKAAVLRQLPVFLLAADAVGTVSEMGGIRNTISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I879</accession>
    <name>R7I879_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48084">
        <property type="protein sequence ID" value="CDE48084"/>
        <property type="gene ID" value="BN770_01533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="179" mass="19305" checksum="EB2C63E639ACC5A0" modified="2013-07-24" version="1">MNITVYLGANEGNDPSFRQAVEELGRWIGESGNALVYGGSKSGLMGALAASALAAGAEVTGVEPEFFISESFQMEGLTELIVTKDIPERRTKMIELGDAFIAFPGGTGTLEEVSEVMSKLALKQIDAPCVLYNLNGYYEGLKAQLRHMVEMGLSTEEKQEKVYFAENLGDIKAILGAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8A2</accession>
    <name>R7I8A2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48109">
        <property type="protein sequence ID" value="CDE48109"/>
        <property type="gene ID" value="BN770_00118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="213" mass="24005" checksum="81257FFB395C07DB" modified="2013-07-24" version="1">MKTNCVITIGRQFGSGGRYVGRMLAEKLGIPFYDKELLSEAAKQSGICEEIFEDHDEKPTRSLLFNLVTGMQVHGDAGSYYMDMPLNHKIFLAQFDAIRSIADKGPCVIVGRCADYVLKDRPNTISVFLKAEMQSKVERAVKYYGVDPQKAEDRIRKADKQRASYYNYYATATWGDVNNYDLCVDTGKLGVEGTAELIARFVELRQAMLEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8D8</accession>
    <name>R7I8D8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47741">
        <property type="protein sequence ID" value="CDE47741"/>
        <property type="gene ID" value="BN770_01328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447650" evidence="1">
        <location>
            <begin position="27"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="527" mass="59310" checksum="62DFF282E74A2B4E" modified="2013-07-24" version="1">MKKFLSYLLMLILVASCLSIPAAANAEDWITLRVECFDRSVSGLSVESNLQHDYIQKNFGDPNHIKVELVPVSRWSETDILNTWLAGGTAPDICYTYDTALVQQYVNMGGLTPLNDLLAEYGPNVSEFLGQGVLEYGQFDENGTKVQYYIPARRINVAKLGLFIRKDWLDKLNMAEPTTTEEWVAYLRAAKEAKLGGEQTVPYAMKLYENSPLFSTSVIVDSFLDFSKITKEDWYSLYHEQMPGAKEAYRLLNTLYNEGLISENFAIDNGDIRDRDLNQGYAGFYIEGPTQVWPDYSDEMKKNVGEDAEWIPVNPFVNPDGYTLHENYAANGICIFIPSWVNKETAVAAMKYMDWMAQPENMFYLQNGIEGVHYDHLNEDGLPVGRVTNDNLPDDQKWLSAVDLVFLSNGNSFGNDELNNKYSALAFTGYEDVVARSYEYMAKDSYAPIGFTVSIKAEADYGQMVLAKQAELLTNALTCDPAEFDAVYDRCVQAILDVGGQQIVDERKAAYEAGLIRGDFPMEVLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8R1</accession>
    <name>R7I8R1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48239">
        <property type="protein sequence ID" value="CDE48239"/>
        <property type="gene ID" value="BN770_01589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="395" mass="46222" checksum="766C035169CF8936" modified="2013-07-24" version="1">MPEWSEFWWTSITGPRNLCDAVSRALHNKSSVCLVVPDDLPWRDEMRASIETGMHQMPDMESFYVEFIDVEDECPDIADIGRYLMERYALPEIAAGYRGREKLQKYILDKQVLDNRVLWIKGMNASQEKRWLQFCRDYVPVKDSDGRFVLEARWTDKENERRNLAVIRYGDTIKRYDLTLFNSIYLNREKGTYSAIWQQYAAVMCALLCNTDAETSQAFMDTCDFTAEEPIIGMRKIAADGAYLRRAESSNLHILSLVRKESISAIDAQIWKAQLQVLFPLLEIERVSFIKRYRKQVQEALGEKYHDFRTGRSQYIYQFGETVSDPDNAELGTIYRMTKLRRDADAYQYLLYIPDEQSRSRIELLHDLRNSLAHGNTCAIDKVIEFINGHPFDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I944</accession>
    <name>R7I944_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal large subunit pseudouridine synthase d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000062">
        <property type="protein sequence ID" value="CDE47778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47778">
        <property type="protein sequence ID" value="CDE47778"/>
        <property type="gene ID" value="BN770_01356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="29044" checksum="B6B30057F23C32ED" modified="2013-07-24" version="1">MNEFPLHQLANIDVQYEDNHVIVAVKPPNMLSQADKTGDTDILSQLKEYIKIKYNKPGAVYLGLVHRLDRPVGGLMVFARTSKAAARLSAQMREHEMGREYLCVVEGRVKDRFTCIDYLKKNEYLNKVEICDADEKGAQLAMLSGECLARKNGTALCAIRLQTGRNHQIRVQMANMGAPLWGDNKYGRGIAGQQIALWGYRLVFEHPTRKEIMTFQNLPCGSIWNCYAEELTDMAIRFNNSAEAILNPDIPDNGGIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I974</accession>
    <name>R7I974_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">BN770_01374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47813">
        <property type="protein sequence ID" value="CDE47813"/>
        <property type="gene ID" value="BN770_01374"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="3"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="432" mass="46902" checksum="E2596C5B56B118AF" modified="2013-07-24" version="1">MNDLHEMAAKSREAAWTLAASSLKTRNAALLRMAEVLENHQADIFAANASDIHQAEADGLAAPLLGRLKFREEKLRAVTDGLRALAALPDPIGATTMTHEITPGLKMYRVTCPIGVIGVIFESRPDALVQIASLALKSGNAVLLKGGREAERTNAALCDALREATADVGLPADFAQLLHSREDVAAMLKEDALIDLIIPRGSKEFVRYIMDNSRIPVLGHSDGICHVYVDKSADVEMAVKIAVDSKAQNVAVCNACETLLVHRDIAADFLPKLLPAMREKHVRLLGDEATRAIIPVEAATEEDWRTEYLDYVLSIRVVDSLEAAIAHINRYGSHHTDCIVTRDDAAAKAFLTRVDSAGVYRNVSTRFADGFVYGFGAEVGIATGKLHARGPMGLDGLTTYKYKLLGDGQLMAEMKSGQRAYTHLVLHEDCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9D8</accession>
    <name>R7I9D8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48111">
        <property type="protein sequence ID" value="CDE48111"/>
        <property type="gene ID" value="BN770_00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="425" mass="45682" checksum="E16679F3E51E1FE1" modified="2013-07-24" version="1">MGMSVPERRVIVVGGGAAGMMASIFAGKVGARVTLLERGEKLGKKVYITGKGRCNVTNDCTLDEFLHEVARNPRFLYSALSFFSPQDMMQLLEDAGCPVVVQRGRRVFPATEKASDVTRTLARLMQQSGVEVRYGSRVQALMTETTEDGALHATGVRLMDGTALPAERVILATGGLSCPLTGSTGDGYRLAESVGHTTTPRMGVLSAIETDCDWCGRLQGLALKNVALTLKKGKKVLYSDLGEMLFTHFGISGPLTLTMSCHLPENLAEANVTLDLKPGLTAQQLDTRLQRELAEDSRRQLRNVLPHLLPASFAEIFPELCGVDGSKVCAQVTKEEREKLVSALKALPIPLKKLAPIEEAIVTRGGVNVREIDPATMESRKVSGLYFAGEVIDVDAHTGGYNLQIAWATGALAGQSAGEEEIEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9L1</accession>
    <name>R7I9L1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48260">
        <property type="protein sequence ID" value="CDE48260"/>
        <property type="gene ID" value="BN770_01607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="297"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="800" mass="94032" checksum="B89EBEF27038200B" modified="2013-07-24" version="1">MTKDVSKKNDKKDATQKIEGIICRLKSKRLQMPDVPEEFRMHPDILRAERKLEIRKSGHRGFDVIRQLFFVEETWRYKNRAGEYVSREHTEEFDSFQEYYAFVDGDIYEDACYYQCLFDDELIAAFQLDLEKLMARKCFETQTIDEFIAREKPESGDCPEKSEIMKAYFCRAFHIGVFWYNQAGEKIKQAEREFKYFFDFAAFLKGDLSDADLLFCDGIKHLSDTQGLNLTDARLTSELCEKFGIAYLTYEADEELLQTFPQTEANEKETALILKESRELAENSEEECWSNENRIRYISDLHLNQRIQNAKCKSIDDVCYTMQKIVDTIVRESYGLTLIAGDVASDFRLFKLFVRILNRSAYTSCQQYVFVLGNHELWSFAGKTVRQIVNTYRKLLEEHGMYLLQNDLFYKNDKDDMGMIPYTKLMRMNQEELCAKLRRARWVILGGIGFSGYNEEFNADTGIYRNTIDRKTEIKETQKFEKLYNRLTGMLKGKNTIILTHMPKENWCADKEYHESFVYVSGHTHRNAFYDDGAIRVYAENQIGYHNDNVHLRSFLLDGKYDYFTDYKDGIYEITKEEYQDFMHGKNITMQFNREVEAIYMLKKIGYYCFLCREKTGRVVLLNGGRATTTCIDQLEYYYDHMDRMVAEIQKPLRLFTAYQEQIAKAVRQIGGSGRIHGCIIDIDYYNHLYINLNDISVTPYWASDMVNKRVYPSIPALLKKECPHLYENYKKLISSDEKNALSIRNAKAISEKPTVYLETDIYKTSQKISELQKVNSNILVKWYAHVLAGEQDTVEKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA10</accession>
    <name>R7IA10_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisH</name>
        <name evidence="11" type="ORF">BN770_01629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000094">
        <property type="protein sequence ID" value="CDE48301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48301">
        <property type="protein sequence ID" value="CDE48301"/>
        <property type="gene ID" value="BN770_01629"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE48301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="204" mass="22272" checksum="8CB71B0F47DEB9A8" modified="2013-07-24" version="1">MIAILDYGMGNLRSVQKALEFLAVPCFITDTPSALSTADHIILPGVGAFSDAMTRIRALHLDRAILSAADAGVPILGICLGMQMLFQHSEENGFYDGLGLFPGTITKFRDAGLKIPHMGWNTLDTHPCVLFDGGQSPFVYFVHSYCMADVSPEWTTATCTYGQTFTAAIQRGNVMATQFHPEKSGEVGLNMLRRFAQWKGDKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAN7</accession>
    <name>R7IAN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage portal protein SPP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000097">
        <property type="protein sequence ID" value="CDE48343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48343">
        <property type="protein sequence ID" value="CDE48343"/>
        <property type="gene ID" value="BN770_01665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="452" mass="50697" checksum="00BD037E149CE8D4" modified="2013-07-24" version="1">MFTTYTYQDYLAAEDKIALLCKAIEKFKASAEFVRALNASSYFRGENPTIARKTILRARKIETRGTDGRRHVRAGTEDVVGNRIGSSFLFRFVTQQNQFLLSEGVSLPEETKKRLGADFDHLLSRLGECALLHGVSYGYWNADHLEIIEMARAAGSGFFPLLDEMTGELMLGVQFWQLGAKRPMFLRLFEQDGVTILRVSGKQVDVVREKTAYVRTLRRDALGDTLDVERQGYGRLPLIPLYANQEGKSELTPAIQAKIDAYDNILSDFADNLARANDVYWVLNNFSGTTEDIAEMLEEISRIKAVANLSDGSGSGATAEPHTIEVPYAARQAALNLLERALYNDYMALDMASLTGGSLTNVAIRAAMANLNLKADRYEWQVRHFMQELLTLLHLETEEIHFKRQAIANESELVADIQNMRQDIDQRTALRLNPYIADEEIGGLVKGARNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB69</accession>
    <name>R7IB69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48815">
        <property type="protein sequence ID" value="CDE48815"/>
        <property type="gene ID" value="BN770_01834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="147" mass="16433" checksum="DB3151ADAC1DA88F" modified="2013-07-24" version="1">MSRIETVRAAMMQAMKEHDKERKEALSLLLSALKNKAIDKRADLTEDEENAVVLREIKQCQESIEQANGREDIIAENTLRMKVYQEFAPKMMSEDEVEAEVTAVLAELGLDAPTAKQKGLIMKTLMPRVKGKADGALVQNVLARHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBD4</accession>
    <name>R7IBD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47807">
        <property type="protein sequence ID" value="CDE47807"/>
        <property type="gene ID" value="BN770_01368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="221" mass="25609" checksum="1D1B5C7EFE302EDD" modified="2013-07-24" version="1">MKTPVTHERLQNHLTYSWWKYVLMMVLVIFFWSILFTTTRYRPPEEKKVIVGVYGAGNQTALDAYMEDVRQLLLPDMEEMNTQFIMSDETWGSSVLMTRMTARECDIYLLPKDLFQTYAQQGVFVALEETMPELVSELESRSISLSRGWRTDSDTGEKHLFGIPCADLPYLDTFLYPTADSYYACIFRANGNEENVQAFFDYFIRDMLNEPPAEASEEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBF9</accession>
    <name>R7IBF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">16S rRNA m(2)G 1207 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48811">
        <property type="protein sequence ID" value="CDE48811"/>
        <property type="gene ID" value="BN770_01830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="213" mass="23468" checksum="740D6AD302948B70" modified="2013-07-24" version="1">MAEQYFTADPTCESKQVPCSFVYRGHGLNFMTDAGVFSKGELDTGTRLLLDALPDVYGDVLDLGCGWGAIGVAVKKKYPAAHVTMVDVNRRALELCRFNAVRNGITAECLESDGMAEVMERTFDFIITNPPIRASKPVIYRMFADAASRLNPGGALYLVIRKQQGAESCMKYLKTLYAKVDKVDKSGGFWVLRATEPLKKENEAQEEAADAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBL1</accession>
    <name>R7IBL1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ORF">BN770_01888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000129">
        <property type="protein sequence ID" value="CDE48980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48980">
        <property type="protein sequence ID" value="CDE48980"/>
        <property type="gene ID" value="BN770_01888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="276" mass="30352" checksum="B34291283E0D35BA" modified="2013-07-24" version="1">MLTLGCHLSASAGYLHMGQEAISIGANTFQFFTRNPRGGTAKPLDLSDVAAYLDFASAHGIGQIVAHAPYTLNGCSADPAIRDFARRTMLDDLQRLDHLPGNLYNFHPGSHVKQGVEVATEQICDMLNAILWQDMKTTVLLETMAGKGSEVGRTFEELRAIIDRTELNDKLGVCLDTCHVSDAGYDIVNHLEDVLADFDRVIGLNRLKAIHLNDSKNPCGAHKDRHEQIGKGYIGLEALMRVVNHPSLKHLPFELETPNDLAGYAAEIKQIRELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBQ7</accession>
    <name>R7IBQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48921">
        <property type="protein sequence ID" value="CDE48921"/>
        <property type="gene ID" value="BN770_01860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="182" mass="20760" checksum="F20D427FA4DB5EDF" modified="2013-07-24" version="1">MAHQRKLGRTAGQRKALLRGLVTNLFQNGKIVTTEAKAKEVRRIAEHYITLAVNECDNTVTTTKITHNDKDQKVELQVVNDAPSKLHARRQMTAYLYNVPQQKLADENKKEYKERTKDVKYPVVEKLFREYGPMFKKRNAEKNVAGGYTRMYKLGPRRGDAAELVMLEIINIPGTDATAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBV2</accession>
    <name>R7IBV2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49374">
        <property type="protein sequence ID" value="CDE49374"/>
        <property type="gene ID" value="BN770_01987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="9">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="7">
        <location>
            <begin position="172"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="8">
        <location>
            <begin position="276"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="581" mass="65856" checksum="825692A601E30D2F" modified="2013-07-24" version="1">MIPFPEYPRPALRRDSFLNLNGSWSYAIAADEALPHAWDGEILVPYSPETAASGVRRTLQPNQWLHYQRMFTPPDGDGGRVLLHFGAVDNDCVILVNHREVGRHSGGYWPFSLDITDYLQDGENTLHVAVQDASDCGIQARGKQKLTPGGMFYPAQSGIWQTVWLERVPDCYVQELTITPDVPTRTVRFAVSVSSDCLVSFRVTADGREVALARNTAVHHQASVALKLPEDALHCWSPDDPFLYDVEISLPEETVTSYFAMRQWTCQPDANGIPRFCLNGQPILLNGLLDQGYWVDGLYTPPSDEAMVTELQRVKALGFNLLRKHAKIEPQRWYYHCDRLGLIVWQDFVSGGAPMKSWYVTYLANVLLPVLRHFPDVGLFRHLLSRPNEAGRTLFLREMSDTVNTLYHHPCIALWVPFNEGWGQFNARQVTGILRRMDATRLIDQASGWFDQGGGDVYSMHNYFYPLKVRKHRRVTALTEYGGIAYPMPGHCTHEKSYGYGTAESREDLTARYRQLQLETVLPQLQKGLSALVYTQVSDVEEEINGIFTYDREAVKPDETAVREINVALAAEFARCTRKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBW6</accession>
    <name>R7IBW6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000133">
        <property type="protein sequence ID" value="CDE49085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49085">
        <property type="protein sequence ID" value="CDE49085"/>
        <property type="gene ID" value="BN770_01918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase_6" evidence="1">
        <location>
            <begin position="81"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="264" mass="29444" checksum="6826336C0CF4B197" modified="2013-07-24" version="1">MSTWIDGTVGGGKLYCRKSPSTSAAAWGRFENGTKIKVRDVEGHPDWYETYWNNDVSKVGYVIRNYVDAIVMPEDVKLTFSRENAVIYAEKHSETTDPGKLCSNRNKTFGSATTNDCANFVSQCLCAGGMPMFKGWSYPVSGIPSGWKKASKWSLTESGMNQLQSKGWISQIEHTEVKRGDIIYTYKSSNADGKKYTHVTLAVSDYKNGHCEVCGHTYNQNHVKKDLTASTCRCYHPADNLIVNRTERRVLLPLEGNGATVIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBW8</accession>
    <name>R7IBW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polar amino acid ABC transporter inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48007">
        <property type="protein sequence ID" value="CDE48007"/>
        <property type="gene ID" value="BN770_01488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="224" mass="25003" checksum="72CD8A63E2BB5C37" modified="2013-07-24" version="1">MSERIVKLLIESFPKILLPGLKMTIPLTVIAFSIAMVIAVIAAMIQYARVPVLRQIMRFYVWVVRGTPLLVQLFVVFYGLPSLGIILDPFPAAVIVFSINEGAYCAETMRAALESVPVGQMEAGYCVGMSYLQVMRRIVLPQALRTAFPPLSNSLIAMVKDTSLAANITVTEMFMATQKLVAYYYEPMALYIEVGVIYLIFSTVLTWVQRWGEKKLSAYGAQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICJ9</accession>
    <name>R7ICJ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49315">
        <property type="protein sequence ID" value="CDE49315"/>
        <property type="gene ID" value="BN770_01965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="269" mass="29339" checksum="B135397832E3E438" modified="2013-07-24" version="1">MEMIFCPLYSGSSGNCLFVQYGATRLLIDAGKSGKMIDEALDMIGVDGNTIDAILITHEHIDHISGAGVLCRKHKIPVYATEMTWNAMDAKVGKIPPELRRTFDTFSDFYIGDVGVVPFSIPHDAADPVGYRLWGGGLSIATATDLGHFPRSVRDAVAGSSLVLLESNHDPDMLRHNDHYNERLKQRILGNRGHLSNAACADALLQIVESGTKNVILGHLSGENNTPSLAYHISEDRMTREGIRLGQDLTLDVALRDRVGNIYTLGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICK2</accession>
    <name>R7ICK2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49320">
        <property type="protein sequence ID" value="CDE49320"/>
        <property type="gene ID" value="BN770_01970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="512" mass="59229" checksum="85AE222C4CE9FF55" modified="2013-07-24" version="1">MNEHLAFAQCLQRVLNETELTATEVARRLEMRSRNSIFRILKGKTSPQLNRRFLESFHKHMGEQLTEAQWAALNRALEMDAVGAVEYKSRQALMQLVGAFSEPISPAKVCYLDASGAEKEDSFLHYLQVLFCGALKVNALLFGCCDLGLFRQLQEAIHPVAQRVIVRIDHFIYAGEDEIVSNLVGIQPMVDQPCYHAYLVDAENCPQERLAHYRTGQMTFHVMHQDGSESTVALFLLGKNEFTATVMSTQDLWMSRKVLCDRERFSPIRLLWQLNDENSDFIVYTQQYCKMEHGAAIYYIRPDVPFQYIPLEVLYPVVREGFARMGMTREEYEPNVTALAEIHQARMTNMMRRRRPTYIVLNKAAMEEFVRTGRQSDHLHFLRNFTPKERKQILDVLVQQARENPFFHLYFAQEKLPYTMGEVALYDGRALITMSSGSGYDLRTDHRESCITHPFVLRAYKQFYMNTVVARLADTQTESLNQLEELVRRCEKMIREGQKGNAGNEQEKISGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICT0</accession>
    <name>R7ICT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48317">
        <property type="protein sequence ID" value="CDE48317"/>
        <property type="gene ID" value="BN770_01642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="320"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="533" mass="60090" checksum="63C91C000B42A7DF" modified="2013-07-24" version="1">MITVSNVSLTFGGQKLFSGADLKFMPGNCYGVIGANGAGKSTFLRILSGELEPTTGTVTIPAGQRLSTLKQDQFKYDAYPVLDTVIMGNQRLYDIMKEKDELYAKPDFSDADGERAAELEGEFAEMDGWNAESDAATLLTGLGLPVEMHTMLMGDLKGGEKFKVLLAQALFGNPDILLLDEPTNNLDNRSVAWLEDFLMNFPGTLIVVSHDRWFLNNICTHIVDIDFNQVKLYVGNYDFWYESSKMMQSLMNDQKKRREDKIKELQAFIQRFSSNKSKAKQATSRRKLLDQLTIEQMPASSRRYPWVCFTPEREAGKDILQVSNLNYTQDGVQLLKDVSFIVTKGQKIALVGSNEQAQTALFRILAEEIKPDSGSFKWGVTISTNYFPKDNSKYFDGCNLNMMQWFAQYSPEQLETYMRGFLGRMLFSGDDVYKPVSVLSGGEKVRVMLSRMMLSGANFLMLDQPTNHLDLESITAVNNALINFPGNVLFTSQDHQFITTIADRIIEIKPDGTIADYYCGYEDYLEKIRAQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID05</accession>
    <name>R7ID05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000108">
        <property type="protein sequence ID" value="CDE48437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48437">
        <property type="protein sequence ID" value="CDE48437"/>
        <property type="gene ID" value="BN770_01700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435786" evidence="1">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="476" mass="55092" checksum="FCFB60B028C229ED" modified="2013-07-24" version="1">MRRLLTLLLCLTMLIPALPATAEETEQRLVIAITSEEDALYLPIEEAFFKANPGVTIEYRLYSSNQLNSLLMTNQADFDIIISGYTRMIDMAEKDYLLTLDQIGLEAYPAELLDMSELLMYNEKLFALPISIGQEAWFIHYELSEQNNIEYPAKDGAWTWEEYLEFSKRFPILFGKNREKSLYMMTGASLLDYPALQNVQVDMFLNYLALYPNEINRFFTDYFPTFRQVLKSDALMPRKLDESGILRENRTNDVLMVITSADNPIGMMQSFMAREGYLDTLALMHDPNLTFSGGPTEEEIVNEILPSLNSWMLLPVPVFDKNDVRYLGYMTACGIMKNAEHKELAAKFIEAMYSEEALDMGVVMGETAFIGRECPSQLILDKYAYYPVFMDENGTQVYTVEAGRSFEYIPFTSMYAEHMYYEAQEYRSHLAVTRFHAQRDFYNAVWSYLQEWYLGHISDAELQESVTYLVEMALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID32</accession>
    <name>R7ID32_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GGDEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49218">
        <property type="protein sequence ID" value="CDE49218"/>
        <property type="gene ID" value="BN770_01942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="253"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="383" mass="42682" checksum="0962EEFCE2C5A185" modified="2013-07-24" version="1">MEIYLRQRSGIVCLITIALLLVFSHLYNPSSASRRFRRMCIYALCHVVLTILTEVTANLLDTTPLLVNRLPHLLCCATAIAFLGEMCWYIASITPLQGRSLQVVRIVTILIPPLFLFAAPLFPMHFTQGLVINYPDGAFMHLYFFIGIALCLVSAVLLFRARFQLDRLVCVLMTLVLVLMAAMTCLQMAFPELMLSAVKLTVITLMMYFIVENPVGTYHDRAMIDLPTGLRNHNALQEDAVNLANNWQLSSNGSIGVVACDLNDLKRINDTHGHQAGDEAIALIGRVLRTELVSAYGVYRTGGDEFTAIYVNQHEDVMIAEMQAARDNLRSRHLDCGWAVHAALGSAYATSQSELSIRDIMQRADEAMYADKARQKGAGNVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDA9</accession>
    <name>R7IDA9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S4 RNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49431">
        <property type="protein sequence ID" value="CDE49431"/>
        <property type="gene ID" value="BN770_02011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025490">
        <property type="entry name" value="RNAbp_HP1423"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038881">
        <property type="entry name" value="RNAbp_HP1423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10188" checksum="652206870B4AA7A3" modified="2013-07-24" version="1">MRLDKYLKVSRIIKRRTVANEACSGGRVTLNGKVAKPGAEVKPGDIMTIRFGDHLGRYEILAVPGTVRKEGAAEIYRVLEEDAAMASERGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDK4</accession>
    <name>R7IDK4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombination protein MgsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48657">
        <property type="protein sequence ID" value="CDE48657"/>
        <property type="gene ID" value="BN770_01774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="45"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="431" mass="47080" checksum="5AC825DB352AF147" modified="2013-07-24" version="1">MTDLFSGQEAPLADRMRPRTLAEFIGQRHLLGEGRLLRRAIEADRLTSSIFFGPPGCGKTTLASIIANSTKSAFVQLNAVTSGVADVRKVIADAQERRAYGQSTYLLLDECHRWSKAQSDSILPAIERGIIRFIGSTTENPMVSMTPAIVSRCRVFQFEPLTERDVLTAMHRAIDDPERGYGQMNIIADDDALRHIARIAGGDTRAALGAVELAVLTTPADAQGIIHITLAVAEESIQKPMIRCDESLYYDMLSAFCKSLRGSDSDAALSWFARLIYAGVDPKLIARRIIAHASEDVGLANPIAMLQAEAAARAVEFVGMPEARLPLAQAIIAICESPKSNSVCAAVDAAMADAEKGGYGAVPVHLRDTHYAGHDRIGSGDGYKYPHDYPGHYVRQNYMPVELQGKKYYFPSDMGHEATIRKNQEIREGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDP0</accession>
    <name>R7IDP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49939">
        <property type="protein sequence ID" value="CDE49939"/>
        <property type="gene ID" value="BN770_02200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="334" mass="37177" checksum="2E86F844D8C85F37" modified="2013-07-24" version="1">MNCLIFGGSGFIGTHLIHRLKDACVKPGDCIYDLDLVMPGEEGVVPGVVEKNEGVVYRRVDVRKPIALDFTPTPDDVIFNLAAVHRTPGHPDYAYFETNIRGAENVTAFAEQHGIRKILFTSSIAPYGAAEELKTEDTLPTPNTPYGISKLVAEKIHQIWQAKEAKRELTIVRPGIVYGKGEHGNMTRLYNSQKKHYFFYAGRKDTVKACIYVKELVRFFQYRMIDHDFPGVDVYNCTFEPAYTIEQICSAMQAATGMKRHIPLIPGGLLMTAATILGPIGGKKVGIHPARVKKLMVSTNISGQKLAESGYAFHAGLEDTFRDWFEDCGKQGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE76</accession>
    <name>R7IE76_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49925">
        <property type="protein sequence ID" value="CDE49925"/>
        <property type="gene ID" value="BN770_02189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="187"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="366" mass="41556" checksum="B245E6553D19C35B" modified="2013-07-24" version="1">MKILHITYGFNGGGVGFVIANYCANQPMPGITFDIVGESIGKPHLLQERFEKAGFHTFYVTPKKQSLLKNIKEMRRVIQQGHYDAVHVHFEEWSFLYLWIAKLCGVKVRVCHAHMAYMTGASAKPHYRLFRVLLNRFATLRLACSKDAGDHLYGKHPYTVLKNAIEAEKYVYHPETRRHIRTQMGLTDKFVVGVVGRLTYQKNPQFTVEIFAKVKEKRPNAVLMFIGQGELEEEIRRMVQAKGLTDSVLFLGLRTDVPDLMQAMDAFVLPSRFEGLGIVYIEAQAAGLKTFATAEVVPQEACVDESLFTYLPREATAQQWADAMLAADTTQRENKLEVIQSHGYDIHQEAEKLRALYLKGKAEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEC4</accession>
    <name>R7IEC4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000126">
        <property type="protein sequence ID" value="CDE48932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48932">
        <property type="protein sequence ID" value="CDE48932"/>
        <property type="gene ID" value="BN770_01870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="83" mass="9562" checksum="D62264A7BBB3C9E8" modified="2013-07-24" version="1">MIALKILDMLLRLYMLVVLAVVIIRVLQVTPNKWTNLLDRMTEPLLSPIRAQLNKHLPESWNAVDLSPLVLLLLVWLVRAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEE9</accession>
    <name>R7IEE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE50005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50005">
        <property type="protein sequence ID" value="CDE50005"/>
        <property type="gene ID" value="BN770_02230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435835" evidence="2">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="161" mass="17209" checksum="5E192E32685D5B99" modified="2013-07-24" version="1">MRKLFALILILGVLACALGFYAADTFETSDYYRVLNPVFRTAVGHDIDPDTVKDMMAIHVDGNLPGVGEFNFSLNALIDGGVDLPGLGHVSLSDLLGKELNFAQRLQAKAVIAGYGWSHEIKLYGGIAAGVMAFLLXXDGGIGAGVMASLLVGTHRPKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEJ9</accession>
    <name>R7IEJ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49733">
        <property type="protein sequence ID" value="CDE49733"/>
        <property type="gene ID" value="BN770_02110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="170"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="231"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="459" mass="51247" checksum="583FCF24E44E4D97" modified="2013-07-24" version="1">MDKRRIIRKPYSFRGRMIAALMIGSLLATVISLFLAFCVTHINLLQELKVRERAVAIYLMELEQRTELRTDELARLVEQNGIEVAVLSDEDVAALSAGTQRELKRAGIAYESTTWKSQRNPVTYVQMRTGVLAITAGGDGSSYGIAFARIIFGSTSFLAVFALMVTLASSWISKPVHEITNATRKVKEGDFTVKLDAAHAPGEIEELMRSFNAMTDALSRTSYLQKDFISSISHEFKTPIASIRGFARLLQMPGLTEAQRQEYVDLIAQESDRLSRLSQTLLRLSALEQQSAPASLKEFSLDEQLRQVILRLEPTWSARGISWQLDLNSVTVVSDEELLSHVWMNIIQNAIKFSPENAVIEVRVFATDTATVEITDHGIGMDDATVKRIFDRFYQADRSRKQEGVGLGLCLVKRILDMLGGTVSVDSRPGEGSTFRIHVPFRPKYDEAAHTGEREGKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEP8</accession>
    <name>R7IEP8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="8">Glu-ADT subunit A</shortName>
            <ecNumber evidence="8">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gatA</name>
        <name evidence="11" type="ORF">BN770_02141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49793">
        <property type="protein sequence ID" value="CDE49793"/>
        <property type="gene ID" value="BN770_02141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="486" mass="52069" checksum="BFE6BACF6B8FFB87" modified="2013-07-24" version="1">MKITRMTLLALSDAMQRGDLTSREVTQAYLDRIHQVEGKVQAYISLNEEEALRQADECDKKRQQGEKVSPLCGIPVAVKDNICVKGGKTTCASKMLADFVSPYSATVWEKLQAAGCVLLGKTNLDEFAMGSSTENSAFHPTHNPRDLSRVPGGSSGGSAACVAADEAPFSLGSDTGGSIRQPAAFCGVVGMKPTYGMVSRYGLVAFASSLDQIGPMTKTVADNALVLDAIAGYDCRDTTSIKRGYTPMNREMKAGVKGLRIGLPKEMFGEGLSADVRKAVMNAAKTLERLGATVKEVSIPSLKVALPAYYVLSSAEASSNLARFDGVRYGHRAAEYADLEELYLKSRSEGFGAEVKRRILLGTYTLSAGYFDAYYKKALQVRTLVIRELNAVLKDVDCLLSPVAPTTAYKIGEKTMSPLEMYLGDIDTVPVNIAGIPGLSLPCGLDRAGLPVGVQLMGATFSEPLLYRVGYALEEALGEICKEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEW4</accession>
    <name>R7IEW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine or other phosphorylase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000153">
        <property type="protein sequence ID" value="CDE49863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49863">
        <property type="protein sequence ID" value="CDE49863"/>
        <property type="gene ID" value="BN770_02172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="256" mass="28522" checksum="16148DCE6027DBB6" modified="2013-07-24" version="1">MLLTDFDASRQAVINPDMLFSPVPDLPETAVSCFSHVTFERMLDMAADVRVLAELGDANAKYPIYRGLWQGTLLTFALAMVGAPSCVAMLEELHALGAKRFVVFGNCGVLNQQIRDCGIIIPTAAVRDEGTSFHYAPPSDEIPANPKYRGAFEAILRETGVDFTEGKVWTTDAFYRETRAKFEKRKAQGCVCVDMECSALMALAQFRGIDVFEFFYAGDNLDREQWDPRSLSTHAKLDEKDRAAYLALELARKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF29</accession>
    <name>R7IF29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50056">
        <property type="protein sequence ID" value="CDE50056"/>
        <property type="gene ID" value="BN770_02257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="100"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="206"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="402" mass="45367" checksum="9F4F625A3B68E5F8" modified="2013-07-24" version="1">MEQTVSVSVDALTQAFSAAFRQEFQPLKQELQTLAANSMSQHLDNGTGTSRIACEGDSMANIKRKYTINGEGVWIQGKSEQEILEKACALMGAQTRPAPAAKHNFRAYALDWFKNFSLPNVEQVTAITYKRELDLHIFPAFGKMNIEDITLSDVQALFNRKGAKKESLMKTRTVLNQIFRKAIDDDLMRKNPLQAFSFRLTGEASDTTQPYSVEEMRLMVERIGRLTNPNDIAYLAVATMQPLRLEETLGLQWQDVDCQAMALHIRRAVTHPDRNAPIVKETKTQEKRDVALTKTTLHYLDSILQGAPTDFVVGGKVPFSYTQVRRMCQRIARQIDFPGKITPQRFRTTVLTDIYDQTRDIKLTQAAAGHKTADMTLKHYVKCRQINQASASAIDAIYGNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF40</accession>
    <name>R7IF40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49187">
        <property type="protein sequence ID" value="CDE49187"/>
        <property type="gene ID" value="BN770_01931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="89" mass="9675" checksum="118693A0F275FF1F" modified="2013-07-24" version="1">MCDISSCRSPVDVPMAARAAKYCAVKEQSSPMSAISTSRPQRVQMYVVSPPAIPTLMMSATTIGTSRSNVASSILNRGARMLSLRKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF74</accession>
    <name>R7IF74_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">BN770_02285</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50111">
        <property type="protein sequence ID" value="CDE50111"/>
        <property type="gene ID" value="BN770_02285"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE50111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="211" mass="22661" checksum="8022D16800FA7121" modified="2013-07-24" version="1">MIVSPSILAADVLNLESATARMIAAGADWIHVDVMDGHFVPNLSFSPSVVGALHERFTIPLDVHLMLDQPEKYVEAFCRAGASSITIHEEIAADRAEILRCIRAQGVKTAVSIKPNTPVDAIIPLLPLCDMVLLMSVEPGFGGQKFNPVVLDKLRQLRAIGYTGLTEVDGGVSLSNLPLLHECGLDAAVMGTALFKSANLAEDIAKIHQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFA0</accession>
    <name>R7IFA0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaA</name>
        <name evidence="14" type="ORF">BN770_02233</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50018">
        <property type="protein sequence ID" value="CDE50018"/>
        <property type="gene ID" value="BN770_02233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="141"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="13">
        <location>
            <begin position="353"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE50018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="447" mass="50568" checksum="2804A0CF07933653" modified="2013-07-24" version="1">MDMEELWSKTREVLRAEVNAVVYNSLLGSNNLVPALLDGDTLVLRVVMDNLKLLITNQWYSTIVRALSQVAGHQMDVEILTQEEIEARPQLKQKAVEEQETVLESSVALNPKYTFETFVVGSGNRFAHAAALSVATDPAHSYNPLFIYGGVGLGKTHLMHAVGNFIREHDPSKRILYIPGETFTNELISAIQQGRNIQFRNRFRSVDVLMVDDIQFIAGKESTQEEFFHTFNTLHTAGKQIILTSDRPPQEIARLEDRLKSRFAWGLTCDIKKPDVETRIAILREKARQENITMDEDVYEAIATRVESNIRELEGSLTRLVAYAQLTNRPITVQLCEEALHDIFAKKVRKEVTAQVIMQAVANYYSITVDDLIRPTRRREIAVPRQIAMYITRDLTNLSLPQIGQVFGNRDHTTVLHGCNQIANAIKNDPSMASVVNDLKEIIVDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFA4</accession>
    <name>R7IFA4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="10" type="ORF">BN770_02236</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50023">
        <property type="protein sequence ID" value="CDE50023"/>
        <property type="gene ID" value="BN770_02236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="rADc" evidence="9">
        <location>
            <begin position="29"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="282" mass="31347" checksum="6DAE3B1DD6FC9EC9" modified="2013-07-24" version="1">MSKTKERIHDSNLRYKQGLGQNFIYDEDLLAALVASSEITKDDDVLEIGPGAGSMTKYLCDAAHHVLSIELDERLIPLLTAFLAERDNFTLVQGDVMTLNLADMTKDLRKPLSVVANIPYYITTPLLTMLLASPIPIRRMALMVQKEVADKVLAQPGDDGWGMLSVRSQFYCDPYLAMDVPAKCFTPVPKVDSAFIVLPWRETPAVQVQDEADFFRVAQAAFALRRKTMTNGLCAAFHMERADAASLMQTAGLDERIRGEKLTLAEFARLADAFTAWKAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFB2</accession>
    <name>R7IFB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Signal peptidase I</fullName>
            <ecNumber evidence="4 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 6"/>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49237">
        <property type="protein sequence ID" value="CDE49237"/>
        <property type="gene ID" value="BN770_01952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="175" mass="19920" checksum="86F5062A88FAF9E6" modified="2013-07-24" version="1">MSDALLFFVCLAAALGIRQFIGCAAVVKGRSMLSTLHPRDVMLAVRPPLLYRHIRRGDIVLCRYPGRYWRNLRFVPQTFVKRVVGLPGETIEIADGVVLIDGEPLSEPYLDPAHCRFRRSMPPRTLGADEYFVMGDNRDNSNDSRSVGALKRTAIRARVAKVLFRLPSRKRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFE3</accession>
    <name>R7IFE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50176">
        <property type="protein sequence ID" value="CDE50176"/>
        <property type="gene ID" value="BN770_02315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="280" mass="31848" checksum="24F482BAC58EBC30" modified="2013-07-24" version="1">MRVHLHRVRIELAFQVAAHHLVAGIIMRVCAFALKQTASRFFRRRIAGIRMVMRALAFRQAAGVRPGHFVAAVIMDMRHVGVRRNVLGANQRARFRRAIRRVLMAFTLKQTASRFFRPVARIRVDVPLAFRQRAGQLLLPVVAGIRVLVHRMLLQRADKNAVAVVALLVMLVDVAIPVAAAEFTLRIIAIGGMVVRLKAASHNIGKDRRRLALGNQAGQLIHIAVRRVGMLLQPAVRFRRHCQTRHHQHIRRADGDNECQRRDRLEQTHPALPLRNVFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFN7</accession>
    <name>R7IFN7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flotillin-like protein FloA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">floA</name>
        <name evidence="7" type="ORF">BN770_02298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane raft</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flotillin-like FloA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50148">
        <property type="protein sequence ID" value="CDE50148"/>
        <property type="gene ID" value="BN770_02298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01562">
        <property type="entry name" value="FloA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022853">
        <property type="entry name" value="FloA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12127">
        <property type="entry name" value="YdfA_immunity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="334" mass="35695" checksum="5EEF9830F5B6B10C" modified="2013-07-24" version="1">MDGNMAMILGIIAVVFVVVCVFLSFVPLGLWISALSSGVHVSMGALIGMKIRHIKPHRLVQPLIKANKAGLGLNISQLETHFLAGGNVDRVINALIAAQRANIPMAFEKACAIDLAGRDVFEAVQMSVTPKVIETPVVAAIAKDGIELRAKARVTVRTNIDRLVGGAGEETVIARVGEGIVTTVGSAETHKQVLENPDLISRTVLSKGLDAGTAYEILSIDIADVDVGRNIGAQLMMDQAESDRRVAQAKAEERRAMAVAHEQEMKAAVQEMRAKVVEAEAEVPKAMAAALREGKLGVMDYYQMQNTIADTSMRDSIAKASAPQSTPTHSLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFZ2</accession>
    <name>R7IFZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50371">
        <property type="protein sequence ID" value="CDE50371"/>
        <property type="gene ID" value="BN770_00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025957">
        <property type="entry name" value="Cys_rich_KTR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14205">
        <property type="entry name" value="Cys_rich_KTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="58" mass="6874" checksum="2CE5E00A2333B2AA" modified="2013-07-24" version="1">MQKQAEWILCPVCGNKTRDRTRYDTVLKNYPLYCPKCKQETLIEAENLKVTVIKKQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGB3</accession>
    <name>R7IGB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50501">
        <property type="protein sequence ID" value="CDE50501"/>
        <property type="gene ID" value="BN770_02422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="53"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="292" mass="32780" checksum="47C4086700E3C7D1" modified="2013-07-24" version="1">MQCTLCPRACRAERNESTGNGFCQLPTTMRIARIAPHLWEEPPISGKNGTGAVFFSGCTLRCAYCQNADISHRNAGRPFTPRELADSLRRLEDMGMHTISFITATPYVPQILETLDIYRPHVPLVWNTSGYETVETLRMLDGVMDVYLPDLKHRSEKMGQLCAKASNYFAATSAAITEMVRQTGTPVYDENGIMTRGTLIRHLILPGLTSESCQLLDWVKENLPEGVPVSLMRQYIPCNNVSIPGLTRTITNREYIRVRDHMLDLGLPGYLQEPESASEDFVPVFCKDESFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGP0</accession>
    <name>R7IGP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000178">
        <property type="protein sequence ID" value="CDE50755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50755">
        <property type="protein sequence ID" value="CDE50755"/>
        <property type="gene ID" value="BN770_00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="171"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="334" mass="38415" checksum="A4A95FD160E676C6" modified="2013-07-24" version="1">MLMNSSEYLSIVDSIKREITDAQYRAAVHVNADLLLLYYDIGCIINEHKSWGNKFIDNLASDIHMAFPESKGYSVRNLKYMSKFAARFSDREFVQAALAQITWYHHIALMDKVKNADEHVWYAKEAAKNGWSRNVLVHQIESGLYQRQVLVDKVSNFERRLPSPQSELAVQTMKDPYVFDFIPFRKNMIERDIEQALVRDVTKLLLELGTGFAFLGNQYHLNVGGDDFYIDLLFYNLNLRCYVVIELKTGDFKPEYAGQLNFYLSAVDGILKKEQDNPSIGLLLCKSKNNLVAEYSLKDISKPIGVSEYKVTSSLPDDLEKQLPSVEDIQKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHB7</accession>
    <name>R7IHB7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49982">
        <property type="protein sequence ID" value="CDE49982"/>
        <property type="gene ID" value="BN770_02214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="435" mass="50431" checksum="2A3AB591163387C4" modified="2013-07-24" version="1">MELFSTNKLFKEEKYEEILALWQNDESRNRMTDWDKWYVLLSLNKQKRYQETLDAYKLLRAKRDESTETELWQRIEDTVCRALYYAHVKTFDFRQGDSSKLFKQVDYILAHSSDSPYSVKGKAALFVVSAAEEGKLAVDNASELIIRYLDAMNPSTLGREEFEYIDQQGNRRAKAPDREIWYAARAKALLKLQRYGECMACCDEALRELRGFHYSNDSWLRYRKAKCLLALGKPDDAKRCISEAQARGAHHWCLSQVLFEIERNGGEHQAALALGAECALADPSHEMRVSFYEDFADYLEQSGLTHEAALHRRLVILIRQENNWGLKQKHLGWTNLDDVSAMDKAEILKTLKPLWKEWRSAAKSYLTGVVIRVLPEGGSGFIQDERGGQYYFNAKDYTHGKQKPIVDQRVRFTLVDKLDRKKNEVKKNAVDISII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHC2</accession>
    <name>R7IHC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC-type sugar metabolism regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49987">
        <property type="protein sequence ID" value="CDE49987"/>
        <property type="gene ID" value="BN770_02219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="188"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="290" mass="33402" checksum="B08187976394524F" modified="2013-07-24" version="1">MKFAETINGYNAMGREDAEYEACYAIAEHHTVGGLHCHDFYEFYIHYQGGKVYYVDGSVFPLQNNQLIIMPPFRMHGLVGGSSLQNYERGFLYLRPETLRKLGFGQIDLQRYFDSRLQSGKFYYELPQADALACKQLLIDISAQQDMPDEMVQFRNYGRIIDFMVMVCQAVQGTTAPIQPSVVNDVIFDVLQYINDHFTEPLKLEDIARRFAISVSYLSHEFTSYAGRSVYEYILYRRVQLAKENLLTDMSLSEVADRSGFGDYSGFLRSFRRMTGMAPNAYRKQRSGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHC6</accession>
    <name>R7IHC6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000200">
        <property type="protein sequence ID" value="CDE51194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51194">
        <property type="protein sequence ID" value="CDE51194"/>
        <property type="gene ID" value="BN770_00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="148"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="315" mass="34688" checksum="C45857E60840E1E7" modified="2013-07-24" version="1">MNTNRWMQEVNARFPVRKSKVQKAQFRQYVLQKAQEMGYTARMEENKAICTNRNIVVGDVDKAKVLVTAHYDTPATVGLPNVMLPMNRPMFYLVQALIALVMVVFIFIPTGIVKKLTGSIFCTEATLIGLYCLMMYLLLAGVPNPHNVNDNTSGVCGVLALMESFAAEKPGKIAFVLFDNEEKGLLGASGLAKAHKQVAKETLVLNMDCIGVGEAMLMLVPKAAREKYPALGETARKSSGIPVVLGNMEKCNFSSDQKHFKLGVGICACRKKKHVGWYCSKIHTKHDTTYDEITLQGVADTVEAVLRQVVGKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHC7</accession>
    <name>R7IHC7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="15" type="ORF">BN770_00267</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51025">
        <property type="protein sequence ID" value="CDE51025"/>
        <property type="gene ID" value="BN770_00267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="42"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="222"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="419"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="657"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="583"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE51025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="805" mass="91623" checksum="0000B61F79987BFF" modified="2013-07-24" version="1">MEFKPYDPKTIEPKWQKRWADSHVFEAKNDYTMPKFYGLIEFPYPSGQGLHVGHPRSNTAMDIIARKRRMEGCNVLFPIGWDAFGLPTENYAIKNKVHPAIVTKKNIDHFREQLQKIGFSFDYSREVNTTDPSYYRWTQWIFLQLFKHGLAYKSEMPINWCPSCKCGLANEEVVGGVCERCGTQVIRKVKKQWMLKITAYAQKLLDGLDTVDFIDKVKVQQRNWIGRSVGAEVDFSLTVPGEKVRVFTTRPDTLFGATYMVLSPEHPLIDKLKDQITNYDACMAYRAEAAKKSDFERAELAKDKTGVQIEGVRAVNPVNGKEIPIWLSDYVLMTYGTGAIMAVPAHDTRDWEFAHKFGIPMIEVVAGGNIEEAAYTDIQDGVMVNSGFLDGMKVAQAKEAIIEYLEKNGLGEKKVNYKLRDWVFSRQRYWGEPIPIVHCDKCGMVAVPEDQLPVTLPMVDNYEPTDSGESPLSVMHDWVNTTCPCCGGPATRETDTMPQWAGSSWYFMRYCDPHCETAIASPEALRYWLPVDWYNGGMEHTTLHLLYSRFWHLFLHDIGVIPAPEPYQKRTSHGMILGENGEKMSKSRGNVVNPDDIIDEIGADAFRVYEMFMGAFDQAIPWSTQSAKGCRRFLDRVWRLQENVTPDEGYSEKLNALMHETIKKVSLDYEAMKYNTAIAQMMTLVNEMVSAGSVTRGELKTLLLLLNPVAPHITEEMWENQGFGGTMTYQKWPTWDEDALVKSEIEIAVQVCGKVRGRVMIPADMTKERAETELQQLPEIQKILAGKNVTKVIFVPGRLVNFIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHE3</accession>
    <name>R7IHE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000202">
        <property type="protein sequence ID" value="CDE51209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51209">
        <property type="protein sequence ID" value="CDE51209"/>
        <property type="gene ID" value="BN770_00039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447974" evidence="2">
        <location>
            <begin position="25"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="592" mass="67059" checksum="1C14877628EDBA2F" modified="2013-07-24" version="1">MKQMGKWLVTAVLALLMMIPAVLAEETASFMTLTVPTTAQEIDLGQNVVTDYDALCRFLDELPDVRKVDMFATKISRKDIEMLAARYPQVKFGWTMRVGDHLVRTDATAFSTLHNNQSATHTSAELSVLKYCTEMLALDIGHNQATDISFLAEMPQLRVLIIACNKVEDISPLANLTNLEYLEVFKNKIRDISPLSGLTNLIDLNICFNYVKDWTPLENLTQLERLWVYNSNNYMENDPIPKEVVRSLKEHLPNTYVDSKSYSTSGGWREHDRYQIVYKMFKSGEYIPFAQSPATLAPGETPAPTGVPTPTPVPTATPEPTATPAPTVRYANMTFDRDAEAIDLGKTVVSDFKKLTAFLDELPNLKKCDMYGTKMKRADMEMLSERYPQVEFGWTMYVGDHLVRTDVTAFSTQHTYQSKFHTSKTFSVLKYCHNLVALDIGHNEVSDLSFLEDLPQLKVLILAANNITDITPLAKLENLEYLELFLNHISDLTPLEGLTHLRDLNLCYNSITDWSPLENMPWLERLWLNYSGKYARINPVPAEVIAQLKEKLPNTEINTTAAHSTADGWRSHARSTLVGDMFRKGIYVPFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHG1</accession>
    <name>R7IHG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Teichoic acid translocation ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51224">
        <property type="protein sequence ID" value="CDE51224"/>
        <property type="gene ID" value="BN770_00329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="286" mass="32301" checksum="D5BF5164AC6C4AD8" modified="2013-07-24" version="1">MRLADVIVRCRELTKVYDLYGEEKDRLKALLGLRANVKKFPALCGVTQDFHRGEIVGLAGLNGSGKSTLARIIAGITQPDSGVCEVSGTVSMLAANIGMNDQLTGRENIAYKCMLMGMEKREIAQIQQQIIDFADVGVYIDQPLRTYSSGMRSRLGFAISAHMNPEILIVDEALSVGDASFAEKCMARMRHFRAEGKTIFFVTHAPWQMLNFCDRVMWLHQGRVVGYDTAERMIPAYVAFTREWTQLDHLQRTQLSPDYETYRAQVENQQRAVWQQRAKETAQKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHY9</accession>
    <name>R7IHY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51225">
        <property type="protein sequence ID" value="CDE51225"/>
        <property type="gene ID" value="BN770_00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447993" evidence="2">
        <location>
            <begin position="22"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="89"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="4">
        <location>
            <begin position="860"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="921" mass="99667" checksum="A6FD4E9EB1F6ABBE" modified="2013-07-24" version="1">MKRLVSVFLVLCMMLSCVAFGETLDGAQGEIMNEVSDVASDEVQTPDEPTQAPVNEDDIVLPDMDDDISILPSDDVNGPDPYRELVLLQPTDLIGTTLSETSVRIGWGSVAFATQYDVYRKRGGEESYTLLGSVPNNRLYYEDTNVTPGQAVYYRVRAVNVSYDGEQAKYVYSPDSQTLSYMTLAKPKLEDPRGLGADTIRLNWSSVSGAQTYEVQMSTNATSGFTTVRTDLTGTLCNATGLKKATGYYFRVRAVRVFSSGEKFYSEYSNVGCGTPMDRPELTVVQSGNNALLSWPASSGATGYIIYRKTGASGSYTLLAKTGAVTSFVDASINLGEVYYYFIYSMRPVGSYNCFSLSSERVYFTALGSVNLCAVRNTGKQEQTIDWDTTVLGANKYYVYSSTTMDGLYTKIGETEGTTYVAKNLVAGTTYYYKVRPVRVFSNGTICYGPWSNVMSQPESGSLTLEGLSAVNLSAGQDISGGYVGDVFSWSAIVSGGSGSYTFKYSLVSLSGGSPIVLKDFSDGYTSLPAGKTSMTTTFTLTLTENYINLINSQKYAMQMEVRDSLGATTAMYAAPATLNEMNFVAPAPVSKVVNKTIRVGENFTLDHGIYTEAGDVANIEIANTNSAISLRDNVITGVNNGYATLLITSKRYPDILIVYNITVGYAPLTIASVQPSASKLNNYETLAWDITFAGGRPNYNVNFKVYRGTTVVVNSNRTETATGRISVNYQPTVAGTYLLEVTITSADGQSITQRSSATVVSNYTPVTVVPSTTASVTNRNLTWTTAYKGTSSVIRRDYTLFRDGSVVATEVGLNNLTFNYTPTVAGSYILRVIVYEANGNKIEVTAPTITVTQGGSGTSGTGTVTGVRVALRRGASTKYGIILRVDKGETVTILERSGSWYYVSYKGTTGWMMAQYVKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHZ8</accession>
    <name>R7IHZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="9">RNAP subunit beta'</shortName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpoC</name>
        <name evidence="12" type="ORF">BN770_00025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51096">
        <property type="protein sequence ID" value="CDE51096"/>
        <property type="gene ID" value="BN770_00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="11">
        <location>
            <begin position="239"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="888"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="895"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="898"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1310" mass="144683" checksum="0B811344A13844E6" modified="2013-07-24" version="1">MFELTNLDAIQIGMASPEQIRQWSHGEVTKPETINYRTLKPEKDGLYCERIFGPTKDWECACGKHKRIRPKDKNLVCDKCGVSVTRAKVRRERMGHIELAAPVSHIWYYKGIPSRMGMLLELSPRVLDKVLYFANFIVLDPGNTAVTNVALHDLINDDQYRAIMEKPDRGSFKAMMGAEAVQTMLRELDLDKLSAELKAEIETLTSKERNRDTEGQKRAHAVKRLEVVESFRASGNKPEWMVLTVLPVIPPDLRPMVQLDGGRFAASDLNDLYRRVINRNNRLKRLLELGAPEIIVRNEKRMLQESVDALIDNGRRGRAVTGPGGRALRSLSHTLSGKQGRFRQNLLGKRVDYSGRSVIVVGPEMKLHQCGLPKEMALELFKPFVMQQLQLRNKGMNVKSAKRAVEKMKPEVWDILEDVIKDHPVLLNRAPTLHRLGIQAFEPILVDGKAIKLHPLACTAFNADFDGDQMAVHVPLSLEAQAEARFLMLAHNNILKPQDGKPVISPSQDMVIGCYYLTIENPNGKGAGRVFRNPDEAHMAYALEQITLQSPIKVRIEREFNGEKGSKIIDTTLGRLIFNDALPQNLGFKKRECLDDMFALEVDQLVGKKQLSNIVDMCFRSQGEHKCALVLDAIKALGYKYATVGSLTVSVADIKIPPVKQQLLDETDKKVAHVNEKFAEGLLSEDERYSRVINLWNTCTNTLRDQILPNLDPFNPIRMFTDSGARGSAAQVSQLAGMRGLMASPTGKTVELPIRANFREGLNVQEFFLSSHGSRKALSDTAMKTADSGYLTRRLVDISQEVIVREEDCFLQRGLPIRGVHVTELLSGKQSIESLEERLRGRTAAADITDPATGEVLVHQNELIDHAKAKTICDAGIKSVFVRSVLTCCTRNGVCARCYGQNMAHGGKVDVGEAVGVIAAQAIGEPGTQLTMRTFHTGGIASGEDITQGLPRVEELFEARKPKREAVLSDISGTVSIHQTNRNKNELVITADAGNYARHTHKAASGTVAVQVGQVVRQGDVLISGATKAKVAKDGTKSTKTTDIKSTLAGTVTMINTKGVGVVEVEVTSSVAEFEQKTYPVTYGSRLRVQEGDHVEAGDILIEGSINPHDLLRILGQSAVQDYLLKEVLSVYRLQGVAVADKHIEIIVRQMLRKVRVEDNGDTELLPGSLVDRSHLEEANMKVLESTKLRVEDGGDTGLAIGSLVEADELEEINQRIRVSGGSPAIARDLKPASVKRVLLGITRASLATDSFLSAASFQETNRVLTEAAIKGKIDPLIGLKENVILGKMIPAGTGMHRYKDIDIRENYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7II69</accession>
    <name>R7II69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51300">
        <property type="protein sequence ID" value="CDE51300"/>
        <property type="gene ID" value="BN770_00367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="269"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="519" mass="57928" checksum="EFD4C4404E2465E3" modified="2013-07-24" version="1">MEKQRVQTPDESTPYAIEMLHITKRFPGIIANDDITLQLRHGEIHALLGENGAGKSTLMSVLFGLYQPEKGEIRKDGETVSIRNPNDATALGIGMVHQHFKLVECFTVLDNIILGVEPTKFGFLQKKEARQKVLALSERYGLHVDPDAKVEDITVGMQQRTEILKMLYRDNEILIFDEPTAVLTPQEIDELMQIMRNLAAEGKSILFISHKLAEIMAVSDRCTVLRKGKYIGTVNTKDTTPEELSAMMVGRNVNFHVEKKPAQPGEVVLKVENMTVASHVHKNNAVKNVSLEVHAGEIVCLAGIDGNGQTEFVYGLTGLEPLVSGKIYLDGQNITRASIRRRSLDGMSHIPEDRHKHGLVLDYSLEDNIVLQRYFDPEFTRAGFLRRKNIRAYANRLIDQYDIRSGQGATTIARSMSGGNQQKAIVAREIDRSPHLLIAMQPTRGLDVGAIEYIHKQIIAARDEGKAVLLVSLEMDEVLDVSDRILVMYEGEIVGELDPKTTTAEEIGLYMAGAKREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIG7</accession>
    <name>R7IIG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein ComEA helix-hairpin-helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51420">
        <property type="protein sequence ID" value="CDE51420"/>
        <property type="gene ID" value="BN770_00427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435929" evidence="1">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="130" mass="14092" checksum="D4FA19DB0117B227" modified="2013-07-24" version="1">MREWRQGVRKLLLLLYTAALLISLSCFLWNASAPVRVHSAPKCYPSKGDEFSLAPVPTLPADSILNTGDAAALDALPGIGTVLSERIVAYREEHGAFVYPEELRNVKGIGEKRLQAILDALAGESAEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIH1</accession>
    <name>R7IIH1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51589">
        <property type="protein sequence ID" value="CDE51589"/>
        <property type="gene ID" value="BN770_00504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005970642" description="FAD:protein FMN transferase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="364" mass="38265" checksum="7F880D522A821C0B" modified="2013-07-24" version="1">MKKTAVLSGLMALTLLLGGCSAQQAGGETPTTPPAAAATVDPAEKTTGVGFYFDTVVTITLYGADDTLMDDIWAACKRYENMLSKTVEGSDVSRINNAHGQTVTVDAETWNVLSEAKKLNRLTGGAFAITIAPLTAQWDFTGGTNRMPTDEERLAALPLVDDEQLTLGENNTVTLPAGMQIDLGGIAKGYIADQVAALVRGRCSGAMLNFGGNVYAVGTKPDGSAYRVGVQDPDDPNNSSPIGAFSVIDPSAVTSGPIGVVSVIDRSVVTSGIYERGFTIDGVRYHHILSPWTGLPSDSDLASATIIAESSMDADALATACIVLGSEKALQLTQENGYPALMILRDGTVMMNDLMKQWGYTSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIR0</accession>
    <name>R7IIR0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51520">
        <property type="protein sequence ID" value="CDE51520"/>
        <property type="gene ID" value="BN770_00475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="172" mass="18749" checksum="4E43B24A8E1E346A" modified="2013-07-24" version="1">MAQNPTFVITMADGREMKGELYPETAPQSVGNFIALANSGFYDGLIFHRVIPGFMIQGGDPKGTGIGGPGYHIKGEFAMNGVNNPLKHTYGVLSMARSMMPDSAGSQFFIMTSDSPHLDGQYAAFGKVLEGMDVADAIVSVKRDMRDKPLEPQVMKSIRVETFGQTYPFEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIZ1</accession>
    <name>R7IIZ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">BN770_02444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50577">
        <property type="protein sequence ID" value="CDE50577"/>
        <property type="gene ID" value="BN770_02444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="122" mass="13336" checksum="BA4CE7FC8E8D6637" modified="2013-07-24" version="1">MIQPQTRLKVADNSGAKEIMCIRVLGGSFRRDGSIGDVIVASVKTATPGGTVKKGDVVKAVIVRMRKNKRRPDGSYIKFDDNAAVIINDAKLPRGTRIFGPVARELREKDFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ37</accession>
    <name>R7IJ37_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51650">
        <property type="protein sequence ID" value="CDE51650"/>
        <property type="gene ID" value="BN770_00552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="43"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="209"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="325"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="495"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="572" mass="62616" checksum="64949B30E1CC3677" modified="2013-07-24" version="1">MDVKTAYEQWLHDFAADADTIADLKAIANDPAEIEDRFYTELSFGTAGMRGVLGAGMNRMNRYNVRRATKGLAKYLLQNPQEAQRGVVIAYDSRRFSAEFARDTALVLAQEGVPAYLFDALRPVPILSYAVRHLHAIAGIVITASHNPPQYNGYKVYAEDGAQVGPEAADGITAFIRSTPYTDCKLMDEEEAKAKGLLKIIGNKEVDDDYIAQVKTLCIQPELLAEEGSKLSIVYTPIHGSGNVPVRRILREVGISNVSVVKEQELPDPNFSTVKVPNPEDPGAFVLAIKLADEVGAKVIFATDPDCDRLGVAVKTGNGDWQLLTGNQIGCVLLHYILSTKQKQGTLPKNGAAVKSIVSTSLANKIAASFGVEMFETLTGFKFIGEKIQQFQDTGSHTFLFGFEESYGFLSSMFVRDKDGVNASLLIAEVACACAAQGITLYDYVQSIFREYGYFVEKVVSKTLPGKDGLTRMKEIMKDLRENPPKELCGMKVTAVRDYLKGTRTADGKVEPTGLPKSDVLYFELEKGNWVCVRPSGTEPKIKLYVNTNASDKADAEKLNADLRVASEALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJK3</accession>
    <name>R7IJK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51661">
        <property type="protein sequence ID" value="CDE51661"/>
        <property type="gene ID" value="BN770_00561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="652" mass="72587" checksum="686B5C668D47279C" modified="2013-07-24" version="1">MLCPNCHAYVPSDAVRCPRCGMPVNLPDDGEKQEDSDLLSFRQGRHLAAHQQAPQPPKPQQRRRRNASRAMEEDMPDAPQEAAPHDAEKRVYGEDEPFYDSEILNPSHAPEEEIAYGKRAPRVHEKGPKRSAKYLQRGTNWMVVLVCAVVAMIGLAFGAYMFLTKTDPGQVLMARMGREANSAALWQVGEERMNNGDLSGAIDYFVKANEQDGKENANASGLLMLGNAYEANGELDKAEEVYAYLYTDIVPSASDAYRNQVRIYLAQGREKEAAELLAVAYKATGVTSFNTQRTSILPPTPGASVTAGYYTAKQTITFAVAEDYDVYYTFNDLNQLPEEGTLYTGPIELGEGDWSLRAVSVNGDLVSDVMKGSYQIYMPTPLQPDVSLAPNTYDKRISITLRPGTLTKDQLEKNPGYAATLTDEVAQTITIYYTIDGSTPDEDSPLYTTGEKIKMPGGNVTLKAISVNGYGKSSTIKEVGYKFNKKPWMKTMMTVDDTLGDWKLGTTTKEAFTQKCGEGSATETVYNYTIGMDMEKVTYDWGYACFARLRTANVLVELYMTRNEFTAPRKTQIGSTEDEVVSVYKDFGQVESPSGNRGLYESEFNKGKIYKQEDGTKIIRYRVETGDSHIWQLDYELNTSGTVDAIRWSYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJN4</accession>
    <name>R7IJN4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter MnhD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000253">
        <property type="protein sequence ID" value="CDE51994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51994">
        <property type="protein sequence ID" value="CDE51994"/>
        <property type="gene ID" value="BN770_00740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="134"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="501" mass="53911" checksum="262E120A84E933C5" modified="2013-07-24" version="1">MSQPLWHSIPYLCILLPLGSAAVTSVLKPRWARYWTMFALLVVTSLSGVISAIFASGAESYTYMMGHFPAPWGNEIRAGQLEAATALFFSLIMLLSLLGGLKKIDEHIDQNKVSLYYVVLLLLTSALMAQVYTNDIFTAYVFLEIMTLAACALIAIRKRGRTLVAATRYMIMNLIGSGLFLLGIILLYDLTGHLLMSNMKEAVAALAKSGQYQVPLTVVVALISIGLSIKSALFPFHTWVPDAYAYSTPTSAAVLSSLVSKGYIFLLMKIMYRVIGLDVIVSTGIQDVLFVFALVGIVMGSISAIRQTDIRRMIAFSSVAQIGYVFMGIGLGTDEGMMAATFHIFSHAVCKSMLFLAAGGLADASNNSKKFRDLRGAGFRSPIAGVAFTIGALSMVGFPFLGGFASKLNFALAAMDVGGARTMLVLITLAISTWLNTLYFLRTVITLYRKPVPGAVYSVARGQRGFCFNASLVAFSIVNVALGLFAQTFVSAITAGLATFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJR5</accession>
    <name>R7IJR5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aconitate hydratase A</fullName>
            <ecNumber evidence="3">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BN770_00654</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51855">
        <property type="protein sequence ID" value="CDE51855"/>
        <property type="gene ID" value="BN770_00654"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006250">
        <property type="entry name" value="Aconitase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01342">
        <property type="entry name" value="acon_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="13">
        <location>
            <begin position="516"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE51855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="647" mass="69236" checksum="ADB3C498F42B79DA" modified="2013-07-24" version="1">MAMNLTQKILSAHLLSGELVPGSEISIRIDQTLTQDSTGTMAYLQFEAMGVKRVKTKKSVAYIDHNTLQTGFENADDHYYIQTVTKKHGIYCSKPGNGICHQVQLERFGVPGYTLLGSDSHTPTGGGIGMLAIGAGGLDVAVAMGGGAYYLACPRVVGVRLHGKLSYGVAAKDIILEVLRRLTVKGGVGKVMEYIGDGVKTLSVPERATITNMGAELGATTSIFPSDEVTHAFLKAQQREQDFVPLSADPDAAYDEILDIDLTALEPLVAKPHMPDIVETVKQCGPIKVDQVFIGSCTNSSYTDMMRVARILKGKTVHPDVSLVIGPGSKQVLTMLARNGALADMIAAGARILESACGPCIGMGQSPRTNAVSVRTNNRNFYGRSGTKSAGIYLVSCETAAVTALTGVLTDPRCLDIDLDIPMPETYTVNDNLVIPPVAPGEEDTVEVVRGPNIQPFPLGKPLADAISGKVLLKMEDNITTDHIAPSDAKLLPFRSNVPYLSDFCLTPVDATFPARAKKEGGGILVAGMNYGQGSSREHAALVPLYLGIRAVVAKSFARIHQANLINNGILPLTFQNEADYDRIAQGDTLSLPNVRETVESGSDTFVLHNDTKDEDYIVLMPLTARQQGCILYGGLLNYTRESAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJU9</accession>
    <name>R7IJU9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51895">
        <property type="protein sequence ID" value="CDE51895"/>
        <property type="gene ID" value="BN770_00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04076">
        <property type="entry name" value="TIGR04076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="87" mass="9831" checksum="27AE81AE3103802E" modified="2013-07-24" version="1">MKRPRLRITLIDRKGSCPCHHGHKIGDSWDFDTERGQLCPMAMHVAFLYADILRYGGSIPGQPDGTAVFSCPDADTLNIFRVERIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJV8</accession>
    <name>R7IJV8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000181">
        <property type="protein sequence ID" value="CDE50882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50882">
        <property type="protein sequence ID" value="CDE50882"/>
        <property type="gene ID" value="BN770_00237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11754">
        <property type="entry name" value="GH94N_CBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037825">
        <property type="entry name" value="GH94N_CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_X" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="814" mass="91342" checksum="39AED112420ED9F9" modified="2013-07-24" version="1">MKYGHFDDKAREYVIDTPRTPYPWINYLGCEQFFGIISNTAGGYCFYRDARLRRVTRYRYNNMPVDNGGRYFYIKDGDTVWNPGWKPVKTELDSYSCRHGMGYTIITGQKNGLTASQLSFVPMGVNAEVHQVTLRNDSDAPKDVILTSFVEFCLWNAQDDMTNFQRNFSTGEVEVEGSVIYHKTEYRERRNHYAFYAVNTPVDGFDTDMETFLGLYNGFENPQAVFTGKMGNSIASGWQPMAAHQVKLSLAPGEERRFNFVLGYVEVPQAEKFVAPGVINKAPAKALLEKLTTDEQIAEAFNALKKHWDNLLSAYVLTTPDEKLGRMVNIWNPYQCMVTFNMSRSTSMFESGIGRGMGFRDSSQDLLGFVHQIPERARERILDIAATQFRDGGCYHQYQPLTKKGNNDIGGGFNDDPLWLIAGTAAYIKETGDFGILDAATPYDCNPDDCGTLLEHLEASFYHVVNNKGPHGLPLIGRADWNDCLNLNCFSDEPSESFQTFSNPNAPDDRVAESVLIAGMFVAIGPELIAILRRRGLDDKADACQKEIDAMNEAILRDGWDGEWFVRAYDAFGRKIGSKECEDGKIYIESQGYCVMGGVGVKDGKAEKALESVHKYLETKHGIVLLQPAYKEYHLELGEVSSYPPGYKENAGIFCHNNPWIIAAETVVGHGDRAFDLYSRIAPAYREEISDLHKMEPYVYSQMIAGKDAKNFGQAKNSWLTGTAAWNFYVISNYILGIKPDWEGLKVDPCIPHTWDGYQVSRRFRGATYAIAIENPSHVCRGVKQVTVDGQAIEGNVLPVFADGKTHQVTVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK53</accession>
    <name>R7IK53_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase/N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000186">
        <property type="protein sequence ID" value="CDE50987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50987">
        <property type="protein sequence ID" value="CDE50987"/>
        <property type="gene ID" value="BN770_00259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="297" mass="32472" checksum="F9F14718236BFC56" modified="2013-07-24" version="1">MAFKPHGIVVPIVTPVTQDGKFNEKAYRDLIEYLASSGIHGVFPFGTTGEFYAHDMGFYREVLAVTKDAVRGRMDIYAGANNITTRGAVEIAKAVEQVGGIDALSVLTPMFVSQTQYEVSEYYREIASETNLPIIIYNNRPKTNVTVEPATVAKLAEIDNIIGVKDSTGDMTNTEEYLRLTRGMDNFHVMMGRDTLIYAALCYGASGAIASCANVAPRIAVDIYEKFRAGDAAGALDAQFRFSALRIATNMGTFPVVLKEALKLIGHDCGDCVKPIQPLNDEQRARLKKVLVDMGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKG5</accession>
    <name>R7IKG5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase NAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51981">
        <property type="protein sequence ID" value="CDE51981"/>
        <property type="gene ID" value="BN770_00733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="281" mass="30431" checksum="3F43F723A523EC9D" modified="2013-07-24" version="1">MFPIVKKRVLNETVTLMEIEAPLVARKALPGQFIIFRIDEEGERIPLTIAGYDREKGTVTIIFQKVGYTTMKLDTLNEGDALLDFVGPLGEPSHTEGVKRAAVIGGGLGVAIAYPQAKALHEAGCEVDLIVGFRNEHLIILKDELAAACTDLTIMTDDGSNGNKGFVTQALQAKLDAGKVYDEVIAIGPLPMMKAVCDLTKPKDIKTIVSMNPIMIDGTGMCGGCRVTVGGVTKFACVDGPDFDGHQVDWAEAISRSRMFRPEEQRAMEKLHKCRLTGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKY4</accession>
    <name>R7IKY4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51983">
        <property type="protein sequence ID" value="CDE51983"/>
        <property type="gene ID" value="BN770_00735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18768" checksum="BBA81279025261CD" modified="2013-07-24" version="1">MFFLLFGFWVLLNGSWTLEIALIGLVVSAALYAFIVKFMGYSPKKEWAIVRRLPRIIGYFLYLVKEVFLSAWATIKLVWSPKLVVEPEITSFHTHVRTLPGKVVLANSITMTPGTITVDMHDDLFLIHCLDTSFDVGKEGFEMERRVMAVEGTPKAKKSKKGAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILB4</accession>
    <name>R7ILB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type uncharacterized transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51417">
        <property type="protein sequence ID" value="CDE51417"/>
        <property type="gene ID" value="BN770_00425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="54"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="489" mass="53530" checksum="5468A39C8B88921C" modified="2013-07-24" version="1">MRNKKQSAHRKFTISPRLRYGAISTAIVALVIVALILINLATTNLETRYGWRGDFSFNAVTTQSETTKQILHDLKRPVKIYALFERGEEDQPLLELLNRYSAASDMVTWEQTPPSLNPLLLTRFSSSTTNVSAQNLIVYCEETDRYRVLTATDFVTLSVDTDSGSYNVSGLAYEQQITSAIAYVTRDTVPTLHIATGHGELGEDSLSAFTTLLMNNHYDVAFEKLSDMTFASGDVLCILSPVKDYTDAEMDIIRAYVQGGGAVLFSCDYTDPIENMPNVLSLLRSYGFLPESGLVMASPDETDTFYNNNRLALLPEMQATDVTLEMMLNGRTAMLMVASRGFDPSPESDNSLLVDAVLTTSAKSYLVDTTASRLSITQSDSDKTGPFALALQAKRFTDTGDVSRAFIIGSSALLTEEQLFTMTDGEEFLVRAVSFLTGDDSIDTSIMVKTALRPGLSVNALSLGSVVLVGLPILVLLAAVIILLPRRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILD2</accession>
    <name>R7ILD2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpF</name>
        <name evidence="14" type="ORF">BN770_00437</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51437">
        <property type="protein sequence ID" value="CDE51437"/>
        <property type="gene ID" value="BN770_00437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE51437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18749" checksum="2F468230BD424DAD" modified="2013-07-24" version="1">MPLNINFQQILLHMFNFVILAFGLYTLLYKPVVAFMKKREDHFADLEKQAQEAKSQAEATLAEYNAKLAGADEEIRQKNAAAAQEADRQRQERMQRAQADADKLLKNARGAAEQERNAMLEGAKKDIAQMVVSATGKLMDKENDPAFDKALYDSFLKAAQEENDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILN9</accession>
    <name>R7ILN9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BN770_00487</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000227">
        <property type="protein sequence ID" value="CDE51542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51542">
        <property type="protein sequence ID" value="CDE51542"/>
        <property type="gene ID" value="BN770_00487"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="PTHR42825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE51542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="341" mass="37819" checksum="274754314F2D8D65" modified="2013-07-24" version="1">MSKQNIDWSNLGFGYIKTDYRYVCRYKDGQWDEGGLETDANITLNECACVFQYCQACFEGMKAYYTKDGHIVCFRPDMNAKRMEDSAARLEMPPFPVDKFVDAVKQVVAANADFVPPYGTGASLYIRPFMIGTNSVIGVKPATEFEFRIFCTPVGPYFKGGAKPIAIKVSDYDRAAPHGTGNIKAGLNYAMSLHAIMEAHREGFAENMYLDAATRTKVEETGGANFIFVTKDGKLVTPKSDSILPSVTRRSLLVVAEKYLHMPVEEREVYFSEVPDFAECGLCGTAAVISPVGLINDHGKEIRIPSGMDEMGPVLTKLYTTLRGIQQCEIEAPEGWILKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I2T5</accession>
    <name>R7I2T5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46209">
        <property type="protein sequence ID" value="CDE46209"/>
        <property type="gene ID" value="BN770_00784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="464" mass="51119" checksum="0D0723575C13A02F" modified="2013-07-24" version="1">MYRKNAWENLAEDEKEQLSAFAKDYMAFLNNGKTERECVAEGVRQAEAKGFKNLMDVVKNGETLKAGDRVYRAWMNKDIMLFIIGEKPMECGMNILGAHIDSPRIDIKQNPLYEDEHLAYLDTHYYGGIKKYQWVALPLALHGVVVKKDGTTVTLNIGDKPGDPVFYISDLLIHLAADQMGKTAAKVIEGDSLNIIIGSEPKKDTDKDPVKTAILDILKEQYGIDEEDFISAELEAVPAGHARDLGFDRSMIMGYGHDDRVCAYPSMAAVLNYEGTPEYTLAAVLTDKEEIGSVGATGMGAMYFENTMAELIACVTGEDKPLTLRRCLQNSRMLSSDVSAGFDPNFAGVFEKRNASIVGNGVTFNKFTGSRGKSGSNDANAEFVAQVRRICDEANVCWQTAELGKVDVGGGGTIAYICAKYGMNVIDCGIPVLSMHAPWEVISKVDLWEEYKCYCAFLKGAREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3H9</accession>
    <name>R7I3H9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46459">
        <property type="protein sequence ID" value="CDE46459"/>
        <property type="gene ID" value="BN770_00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436119" description="NAGPA domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="2">
        <location>
            <begin position="120"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="33498" checksum="C7CA7EA96790489C" modified="2013-07-24" version="1">MKKRLLALLSAIVLMGSVSLAENTEESAETPATAEPMVSLPIDFSPGMPADPDGFTLGDGTWSYEDPTISVQVTQKRKAECDYWVAHIKIADASQLRTMSAGGFDSTRTVKGTIMAKRSNAILAIDGDYFCYTGIGYIVRQGTEYLDHLRGDRDVLLIDEDGDFHYVLRPKRNSLDGTVDGKKVINSFFFGPVLVREGKAVLNPMAEGMAFDEPRQRMAIAQIGPLEYMAICCASQARGSMGMTLQQFARLCADEGAYIAYNLDGGDSTMMIFNGEKINDVLNENTRAISDIVYFASAWTGEEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4H8</accession>
    <name>R7I4H8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46754">
        <property type="protein sequence ID" value="CDE46754"/>
        <property type="gene ID" value="BN770_00068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435379" evidence="2">
        <location>
            <begin position="26"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="457" mass="51175" checksum="46705A4D4A214F52" modified="2013-07-24" version="1">MKLKRFALRGLIVLFVAVALCMFFARTVQTITTPKVQLVQSTSGRFEDKMTFRAQVYFAETEEFTVEEAKDMNITVDKLYVRAGNYVKKGDIIFTAKTPSYEEEIKKVREDYDAKNKELLELDVQNRKLSKESYQNTMYQQLLDAQDTLSEATYEARYAAAKESVVLTGDVSTWQSQLALSGEVSDDIKAAVNKARTAQAAYEEARAAYFAVLDNKKLKVSDDVFQYITKRNGLMEEIEDLNQKMVTLTVLETSLKAVVAPRDGYIIELKVAEGDTYDGTKVAYVMNKEDCVPVLRAPLDSNSTRTIADGTRAEISSDNYGSERTSVEKTTIASDGTKYLQMPMPETYLSSDSTAIRRFMQDGGVDVKITYRAKSATTLLAPSCVRSDGESNYVYVVEYSGGGFLSENTMKVKKTSVTVIERSDSTVSIQEDLSYRSIADREDRALEDGATVMEYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4K8</accession>
    <name>R7I4K8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46580">
        <property type="protein sequence ID" value="CDE46580"/>
        <property type="gene ID" value="BN770_00947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447485" evidence="1">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="381" mass="42807" checksum="A32BD69D4F04AA63" modified="2013-07-24" version="1">MKRILALLLLLLMSTACAESAQLPYAIESGFLIFPAEDGKQPVPIAVKDGFAAKAQELAAENAYLGTPMNLPETLLPYVSDELTGGEELVEIYATEAVIVMHTRSAADGDVLRWAELDGGQYAVYRKIIGTDFWLQTSNAAGNLAEIFIEGEHYAEYRVTLKDGKMLLHSVWGEQVYFIIEPHAICNDGTLTTCTSDGYVYGNHPYSDVTDLPFAEFPTTYEEAVQHLDRTNWAVVNNPNPTDRLHLREKPDRKSVSLGKFYNRTPVYVDEIRGEWAHVTIGCDLSGWMLTDYLAFGADMDKVACAFPQLIVKDEHQEYGADEFVYEYRVFDAPDLSADTMRWNSMESYYLIGVSGEFYIIMNSEEAIGYIPQDWLWEGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4K9</accession>
    <name>R7I4K9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46789">
        <property type="protein sequence ID" value="CDE46789"/>
        <property type="gene ID" value="BN770_01018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32749" checksum="7A501A9092D19BD6" modified="2013-07-24" version="1">MQNYVFMTDSDSDLPLELKQQYDIPVVYMPYSMDGKEYFDDLGQSLNHKSFYDKMRAGSQPTTSALNETVYMEYFEPILSSGRDLLFVAFSSQLSATIQAIYAAREELLKQYPERKFIVVDTLSISAPQTILVLKAHEMYRAGKPMEEVAQWLEDNKLRAQAWFTVDDLKYLQRGGRISATAAALGTLLDLKPILTETLEGKLAAAGKVRGRRKAMSYILEKAVENVADQKEAMGIILHADAMDDAQKLRQMLVEKLPEMDIRIYPVGPVIGTHAGPGTIAFCFLGKKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I564</accession>
    <name>R7I564_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000012">
        <property type="protein sequence ID" value="CDE46393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46393">
        <property type="protein sequence ID" value="CDE46393"/>
        <property type="gene ID" value="BN770_00854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP5_C" evidence="3">
        <location>
            <begin position="66"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="181" mass="19526" checksum="ACF5F275F1815418" modified="2013-07-24" version="1">MLSSKNKLLATYEGATGIKTGYTRKAGRCLVFGAERNGMRIIGVVLNCPDWFDEAARLMDRAFQRYESVTMLNAGESLRTLPVAHSGGASVHAVLAADLRGVVMQGAIPSIEIDLGSEELDAPVIRGTPLGVARLISGGEVIAEVPLVADADVPRDDFPAHWRRIWENWLMVENAPVTNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I592</accession>
    <name>R7I592_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Capsule synthesis protein CapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000025">
        <property type="protein sequence ID" value="CDE46780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46780">
        <property type="protein sequence ID" value="CDE46780"/>
        <property type="gene ID" value="BN770_01014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="4">
        <location>
            <begin position="105"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="443" mass="47006" checksum="09B7B72743AFE2F1" modified="2013-07-24" version="1">MKKDHRGISLGTYVMLGVTGAVLLGCFLILPGLLGQARGTVDVRQVLSIFQTDGMPSLTLSDIPITRGDSTGNLPAPEPTQPPAETAALAIPSATQAPKQGGTVTLTLGGTVDMDDAVRKAGYYSDSQKYDFTEMLSLLRSEMTGDITFLTLENLIQPEVKVSALNAPDAAAELLRTTGVNLVAIGFPKVYDKGADGVRTTLEALHDRNLLTIGAYNTQEKASAICIRTLDNVPVAFLHYTEALSSTGKKAMKSSGASYAVPLANAETISADIRRAREQGAAVVVVSLNWGTSGTSKPTNAQRKLAQAIADAGADVIVGAGTRVVQPVTWLTHKNADGTAAQTLCAWSLGSLLNESRKDGNVAGMLLQLQISWDGQNISFGQVSYTPTYIWRQKVDGAYQYRVVASDQSAPNGMSEEQQGYMAKALRTIQNALADSPITIRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5E1</accession>
    <name>R7I5E1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">BN770_01052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46845">
        <property type="protein sequence ID" value="CDE46845"/>
        <property type="gene ID" value="BN770_01052"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="47"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="124"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="214" mass="23305" checksum="F5BCE427EBA30887" modified="2013-07-24" version="1">MNQNVEKMIAKDLLSISAVFLRPDEPFTWASGIKSPIYCDNRLTLTAPAVRTDVETALKAVIEEYYPDVEVLMGTSTAGIAHAAITAHLMNLPMGYVRSGHKDHGRGNQIEGKLEKGQKVVVVEDLISTGGSVLEVVDVLREAGAEVLGVASIFTYGMQKGLDRLAAANVINHSLSNFDTLCEVAAEEGYIKPEDIARLKKFRQNPSDESWMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5L4</accession>
    <name>R7I5L4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000037">
        <property type="protein sequence ID" value="CDE47164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47164">
        <property type="protein sequence ID" value="CDE47164"/>
        <property type="gene ID" value="BN770_01160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="261" mass="29119" checksum="93496B3EDDA47074" modified="2013-07-24" version="1">MNELDSLLRAAGRMMLDYQSPKVFSKGHHADFVTEADIAVQSYLVDALQKAYPHAKFLAEEEERHVLTDALTFIIDPIDGTTNYFRRRRCSMISIGAVENKLPVFGGLYDPYLDEMYLAERGKGATCNGERIRVSDTSLDKALIGFGSAPYYEELFLLTGRTVSTLLPKIADVRRTGSACRELCDVARGISDGHFEWRLQPWDYCAGTLLIEEAGGRCGDIRGGSVVYDRPMAHMAANARIFDNLREVLQSADCENPDCMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Z9</accession>
    <name>R7I5Z9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">BN770_01136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47080">
        <property type="protein sequence ID" value="CDE47080"/>
        <property type="gene ID" value="BN770_01136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="339" mass="36341" checksum="085AB94E40C04342" modified="2013-07-24" version="1">MHFKAPDIGLDLGTCNTVVYVKNEGIVISEPTLVISRRGDKKPIAVGEDAQRMYGRTSDAEIAIHPIRNGMIANYDATVLLLRAFISKAVGESNLVKPRLVMSIPSEIDEVNRKALTAAVRACGLKKVYLIEKPLAAAIGAGLSVFEPEGCMVVDVGGGTTEVAVVSLGGLVVSQSIPVGGVKMDEAIVNHIKHEFKMLIGAKTAEDVKLDLASALPQENGSSVRIRGRDLLSPSALEIDYTAQQAYGAVREPCRAILTAIKWVLERTPPELASDIMKNGIYLTGRAAQLYALDQYIANELNIQVILAKDPGDCTVLGLGYIVENLALLAQQGRMPQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6B2</accession>
    <name>R7I6B2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47399">
        <property type="protein sequence ID" value="CDE47399"/>
        <property type="gene ID" value="BN770_01244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="386" mass="41020" checksum="D9228ECE764D72CC" modified="2013-07-24" version="1">MCQKVKQADSAYIAGTYGRFDAVMLKGEGAHYEGPDGKRYIDFGTGIGVTLFGACDPDWVAAVTHQLTTLGHTSNLYYTEPQTQLAKLLCERTGMKKVFFGNSGAEANECALKVARKYGEKDSRDVIVTLVNSFHGRTIATLAATGQDRFHEHFGPFPAGFRYTPANDIPALEAILSTGKVCGLLMEMVQGEGGVIPLDPAFVKKAEELCRANDILLMVDEVQTGNGRTGTLYAYEQFGIHPDVVTTAKGLAGGLPMGACLLGERCEHVLGKGDHGSTFGGNPICAAAALNVISRLNEDVFAGVKECAAYIRKELTGAPGVKSITGLGLMIGILPENKTAAEVASACLQDGLMVLTAHEKVRLLPPLNISYEDLAAGLAILKKHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6F0</accession>
    <name>R7I6F0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46803">
        <property type="protein sequence ID" value="CDE46803"/>
        <property type="gene ID" value="BN770_01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="143" mass="15872" checksum="6BD97C8011DB8938" modified="2013-07-24" version="1">MLIRNATLQMSATERTCMDVRVMNGCVWEMGVALVKGLYESEIDLCGDVLMPGRMLETPISAADEKALRLLCRRLYREGVRYFVADCPADALLRVQNRPERRGALPVTALPNPEPLRSGTGMPLTRWTAAGEFVGMMDEHSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I784</accession>
    <name>R7I784_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SpoIIIJ-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47138">
        <property type="protein sequence ID" value="CDE47138"/>
        <property type="gene ID" value="BN770_00078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="7">
        <location>
            <begin position="295"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="361" mass="39600" checksum="6D6B063725A90E3A" modified="2013-07-24" version="1">MKTYEATGKNYEEALQNGLNALHATISDVTVETLEEGSKGLFGLFGSKPCKLRLTLHEVEEEVEEDDPLADLLSSVKVEAPKPAAQPQPQPKPVQPKPQPKPQPKPAQPKPVQEKPAEVKVEAKVEAPMEAPAVEAAPAATDAAPAADAAERPAPVQRKRNDRPKKDKPRQPKAEGESAPKPERKPLPPKAPAAPLEKPVVTMIPDEQIDPASPVGQAQSFLKELTHLMGVDVTVAMGTDAENNIFAQMTGDTLGILIGRRGETLDALQYLTSLRINKGQDHYTRVTLDTENYRAKREDTLIRLANRMANRAVKTGRKVSLEPMNPYERRVIHSALQPNELVDTHSEGEEPKRHIVITLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I795</accession>
    <name>R7I795_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47346">
        <property type="protein sequence ID" value="CDE47346"/>
        <property type="gene ID" value="BN770_01218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="260" mass="30021" checksum="195719F99CE361A4" modified="2013-07-24" version="1">MQDLTQRNRLSATVVLYHSGVEMLSCIQSFVDSDVYLDLYVVNNSPGDASLFTARWNCPGVHYYPVRRNIGYGRANNLIFPKLKSTYHVICNPDVTFAPDVLRRMIEVMDETGATILTPRVLNSDGTEQFLPRREPTIRRLLARRLNFSGARWQQLRSDYTLEGQNINERMNVAFATGCFMMVRTHVIAQQLGGFDPHYFLYHEDSDLSRRVLANGGSILYTPDICVTHAWKRDSAHTFPATLHHLKSTIRYFNKWGWKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7M7</accession>
    <name>R7I7M7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46527">
        <property type="protein sequence ID" value="CDE46527"/>
        <property type="gene ID" value="BN770_00921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="259" mass="27275" checksum="94BFCA2DE58BC682" modified="2013-07-24" version="1">MTLSPLSAAILATLLMYLLTALGAALVFPLRRFHPSVMNLLMALGAGIMLAASYFSLLAPALMSAQSLRQSPLLMCSGGFLLGGLLVLLADALLSRRMRRTPLSDVRRRTVLLIGSITLHNIPEGLAVGCAFGALASPGGAAWRSAWMLAIGIALQNFPEGAAVSLPLRRDGYSCRRSFFFGQLSGAVEPLAGILGVLLAIRVRAALPLLLSLSGGAMVTVILAELLPECQKCPRQRLMVLATLAGFVLMMALDTMGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7X3</accession>
    <name>R7I7X3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease Rne/Rng family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000044">
        <property type="protein sequence ID" value="CDE47373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47373">
        <property type="protein sequence ID" value="CDE47373"/>
        <property type="gene ID" value="BN770_01225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="377" mass="41840" checksum="F6DACF6C77161F59" modified="2013-07-24" version="1">MRTLLVHQGEKPLIGILEDGQLAEVFFPQEGDTAEAVLLGRVERIVPGMKAAFVDIGQEKNGFLPLEEKNTGLSYPKTGDAVIVQIRKEAQGVKGAFLTRDISLCGEHMLLTPMSRMIGVSSKITEDGKRKALKETGRAIAQERFGLVMRTAAENAPEEELAAEAERLFQQWEQIRRAAPTAHVPSVLMQPRSTLEAVLDDYRPRGIDQIVTDDPAVAEKAAGIAPVQVIPENLLTIYKIESQLKKAQERRVWLSSGGTLVIDPCEAMTVIDVNTAKFTGKRELEDTVLRLNLEACGEIARQVRLRNLSGIIIIDMIDMKTPEHRQMVLDALEEAFASDRVKTVIHGLTSLGLVEMTRKRSRPPLREMLAKQEEAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7X7</accession>
    <name>R7I7X7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47606">
        <property type="protein sequence ID" value="CDE47606"/>
        <property type="gene ID" value="BN770_01312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448063" evidence="1">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="116" mass="13260" checksum="3482CFE49BC36430" modified="2013-07-24" version="1">MKKLLSLLLMVLMLLGGAAFAEENEEDTAPVVAPIVTFKSGFYVGYLDREIKITVSCKNKNSATVPEKYLELRNHRGEVLERAFWRNPRYDLTFSVYVTEDMLGGNKLSVWRTARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I808</accession>
    <name>R7I808_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48004">
        <property type="protein sequence ID" value="CDE48004"/>
        <property type="gene ID" value="BN770_01486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018775">
        <property type="entry name" value="RlaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34817">
        <property type="entry name" value="PTHR34817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10127">
        <property type="entry name" value="RlaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="266" mass="30325" checksum="EA166BFFC292BD9A" modified="2013-07-24" version="1">MNQADTIRRKLREIEAANQVKILYAVESGSRAWGFASPDSDYDVRYVFIRPIKDYLRIDPLPDHIDGPLDEVQDYSGWDIKKALGLLGKSNPSLIEWLYSPVVYAQTAAWRHFADCADAYFSVERNLHHQYASAHSTWRNFLQGEQVRLKKYLYALRPLLCFRYVEQYGNVAPVPFDKLCAAVLPDSMRGAVDDLLAQKKQAREKETAPRIPELDAYLLAEFAHAEQVLEALPNPAAPDLGRLNVVFQTMLAETSDDFQNFPNSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I851</accession>
    <name>R7I851_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative periplasmic beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47755">
        <property type="protein sequence ID" value="CDE47755"/>
        <property type="gene ID" value="BN770_01342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435585" evidence="2">
        <location>
            <begin position="27"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="166"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="807" mass="88701" checksum="42D53A12B66B1A91" modified="2013-07-24" version="1">MKINTKRVVSVIITAVMMVVMLPSFAMGESGKKYTETLQPEGWTLVENEGGATLSYTKGGGVDLIEVDGYAFKDLDRDGELDVFEDWRVDYKERSRDLVTNGGLSLEFQLGLKMNPFSVGTPAKTLADTTKTALDLGYRHIRFSSVGAELITTWNNEIQKHIEANTDVVAIPATFIADPLEGSGVTDWPGNLALAATFDPELAHEYGRTLSKEWHSMNLTMNVGPQVDLATEPRWSRNDMTFGEDPQLSIDMTRAMINAWQSTYDDDGNDLGWGKDSVNIQVKHIMSEGAGEGGREAHTLDGAYAVYPGGQFYTSILPYFAAQDLPGKTGMVSSAMTSFSIGVDENGDSVLGERVSTSYNAEKINGLWRAANGWDGYILTDFNTHVDKCFGMEEYTVPQRLWLELEAGIDAWGNMGGKYEEDIAVAMEAYNYGVERLGKEAADQIIFDSTRHILDTLFNVGVVDNPYVSEAVAASVPNNEEHTAMAREALLKSIVMLKNTDNSVIKPAGDEKLTVYIPYKYSPATTSRRGTTPASFAPSMDIAVASQYFNVITDTVGTPSGEGNTYLPGDVIRASAEDIAKADLVIVRVASPKSNAPTTGYDENMKVPADYEYIPRSLQYRPYTADNMYVRFESIGGQITLEAFEGVYGTEYDYVKENRSYFGKTGTVSNEADLDFVLEIDELTGDVPLVLVMNLNSSMVWSEIEPSADAILVSFGGGRTHSARDEILFEIIAGSYEPSALLPMQQPLDMETVEAQYEDVPRDMDCYVDADGNTYDFTFGLNWSGVIDDERVAKYNVPPIVGTNPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8A8</accession>
    <name>R7I8A8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000066">
        <property type="protein sequence ID" value="CDE47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47835">
        <property type="protein sequence ID" value="CDE47835"/>
        <property type="gene ID" value="BN770_01384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="128" mass="14863" checksum="DC70CCFB0B57E921" modified="2013-07-24" version="1">MKKKREENVELADIQAVRERMTQWAIRLCLLLIPVIVGIILSTQGESTTRAGNFVVRIAFLLILMGAGYVAYLRNLERKYWAKYQQIHRMDNLPIDDVHKYLAQAGTKVDLGKMTDEEFQQFLDAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8D7</accession>
    <name>R7I8D7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46762">
        <property type="protein sequence ID" value="CDE46762"/>
        <property type="gene ID" value="BN770_00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436252" evidence="1">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="182" mass="20347" checksum="4F75C85B4BA058FF" modified="2013-07-24" version="1">MKRILMMLAAMVLMTGMAGSAETVYQEIPLPVSAQPTFYTCTDASGNTYDLFEIVKWQEDENHCVTAVTGRFERVVTDDDCETGEYANNGQTVTFPLAADFSAMMLSSMTDADMRMIPVTDLRAWYISAYLDGTAPESGEIVFAYDVSQEDAAFDFWFITVRIALNDAGEVAYMEYEYVPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8N0</accession>
    <name>R7I8N0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46867">
        <property type="protein sequence ID" value="CDE46867"/>
        <property type="gene ID" value="BN770_01066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="183" mass="19096" checksum="04ECCA631D21A0E7" modified="2013-07-24" version="1">MYSLLVTAILLAVGIVLPFLTGNVQVLGQAISPLHIPVLICGLTCGWCWGMGLGIVLPLLRSVLFGMPPLVPVAIPMAFEMAAYGALCGLLYPMLCKKMSKTCWAMLIAMVIAMLAGRLVGGAAKAVVMGIQGNAYTFPAFVTAYFVNTAVGAVIHLIVVPLVVTALEKARLSPLGLKAKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8T1</accession>
    <name>R7I8T1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48259">
        <property type="protein sequence ID" value="CDE48259"/>
        <property type="gene ID" value="BN770_01606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436270" evidence="1">
        <location>
            <begin position="27"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="475" mass="52605" checksum="B903A217D43DBA8B" modified="2013-07-24" version="1">MRGSKKLVSMLLVLCLTLGALPLAMAEEVVDADLTCTITLGNWPADTAAEAEKALFESYRETMKKQYPNVTLVPDYYSYTLSSYVPMAKGGTAPSIFQPPFTDPQLLISQHLVGDVTDALERAGVLDEFSPSYLEMLSDENGRIYGLPRDGYVLGMHINVALFREAGLMDEEGLPIYPKTLQEVAEYGQIIREKTGKAGLVFPASETYGGWLFTNIAWNFGCVGENALEYQDEDGRWVCNFTSDECVAAMEYIRDLRWKYNILNADATTTDWAGAHSLLGTGEAAMNFAADDSVDQPTSNKGLPVEDFALIPFPAGNAGRYALAGGTCYMFAPNITDDQATALMAYLTVLGKMPYLNDQIIEGMRADYAAKRDRGAPVLPAISAWNDADYNAAKQAIIDEYCNVDMRLYNDFFDSITQGTITLRSEEPVFAQQLYRELTAVIQRVITREGADVRKALQKAQDSFQEYLDDEINDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Z8</accession>
    <name>R7I8Z8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47976">
        <property type="protein sequence ID" value="CDE47976"/>
        <property type="gene ID" value="BN770_01466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435567" evidence="1">
        <location>
            <begin position="25"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="662" mass="73875" checksum="D3FFDCE20732699C" modified="2013-07-24" version="1">MKRWISMLLALMLLMLGMATAEDAADDAWEYELVGRAIELVRQMDAQKRGRLFEDTLNITEVACTETPQPIDRGMPRQAFISVNGTDKSASVLFFALMMMDASADTDATDEAENAYLRIVERTFAVSPEFGMDAQETSAAANLLYAGDAPEMGLLLLSYGENGAVLVRWFAENGCVCLTAIPAAHQATELTTDKLSEFYAGEFEEVDLSRAAVLAESELHQPDEDTIRQLALQSAQEMQHWAALSGEQEGIVPWNTAETAVQISILDYDASQMTAFEAQMQQCGKTETKFLDILAIALYPCDAHDASGLLYLRPRVGTPIVVAWQAMNGAVVMRSVYAPQDEEDDTWEQTAVINGIMTARKLVDMVSNDAFVDWQQWRKEDTISDIDRLRSADVSRPTEVWICPDTLSNEWGAVTLRNDEMLTVANQPHTLSLLLCFAPDALICVEISGGAEENDYSAHVPRYTKEDILHKWGDKAYLWDTANLPDMLDWIRSEVIFGDTAEKILRNYIVYDGDGGDLLNGKEYLLQVRLKPEVCESLVIPPEYADAGIQASWLYYPAEMAMNQLAIIDPEEEKSQQWISAHIMEYMRRHGTAEGVTTEEEGWGMTVLIPETGAPVQMLWRVQNGMMRAHVVWMPSEQLRACETNEDLAVLLNAQVAGIVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I932</accession>
    <name>R7I932_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47763">
        <property type="protein sequence ID" value="CDE47763"/>
        <property type="gene ID" value="BN770_01345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="237" mass="27490" checksum="6E8AD3D6EC8C20B9" modified="2013-07-24" version="1">MKIALVEDNGLHQAQIRQEIQNYFDELNEVCELHVFDNGSDMLDHYYSVGGYDLLLLDIQLPGMDGISVARQVRQKDDKVLIAFITSMTAYAVQGYSVYAMDYILKPINRISFRSTLDRARELFRQRTEHYISVTTGDGMFKVDISQIYYIETERHAVRLYYTKGSFHINDTLKSIEEKLKNAPFCRCNNCYLVNLAHVEQVKKDVVIVAGHELAFSRLRYKPFMEALTNYMGGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I947</accession>
    <name>R7I947_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PTS_EIIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48130">
        <property type="protein sequence ID" value="CDE48130"/>
        <property type="gene ID" value="BN770_01547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13303">
        <property type="entry name" value="PTS_EIIC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PTS_EIIC" evidence="9">
        <location>
            <begin position="22"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="352" mass="36042" checksum="AE364E72D48BB7B8" modified="2013-07-24" version="1">MGKVSAFLKRKNVLFSAKRYGIDAMGAMAQGLFASLLIGTIIKTLGQQLNVQFLIDAGNFAQQVAGPAMAVSIGAALSAPQLVLYSLIAVGMAANKLGGAGGPLAVYFITIVASECGKIVSKETKVDILVTPAVTILVGVGLSVLCAPTVGAAASSVGDFIKWATNLQPLLMGILVSVVVGMALTLPISSAAICAALSLTGLAGGAAVAGCCAQMVGFAVMSFRENGVGGLVSQGLGTSMLQMPNIIRNPRTWIPPTLASAITGPIATCLFHLEMNGPAVSSGMGTCGLVGQIGVYTGWLNDIAAGTKAAILPMDWVGLILICFVLPAVLTLLFAFFLRKWGWIKDGDLKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I964</accession>
    <name>R7I964_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48145">
        <property type="protein sequence ID" value="CDE48145"/>
        <property type="gene ID" value="BN770_01558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="321" mass="37407" checksum="E7268A9F21189BA6" modified="2013-07-24" version="1">MREPDKLVSVIIPVYKVEKYLPMCVDSVLNQTYQNLEVILVDDGSPDNCPAICDDYAQKDKRIRVIHQKNAGLSMARNAGLDICTGDYITFVDSDDALHVAFVARLLAACEENGAEIAVGDFMKATPAEYLPKIAAPLANKPVRVVDGREANMMLYRRSEWVRMVTAWGKLFRREMLETERFPDVKLHEDEALIYKLLYRSRQVVMVDGALYLYTANQAGLMANRFTPERMTMLDILDERLAFYRENGETGDLIRFTQNRQFMFAAEYYLHTADNKPFRRKARKKQWALYWPLMRSSYWLRRKLVYTYAMLLPGHFKKLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I990</accession>
    <name>R7I990_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000066">
        <property type="protein sequence ID" value="CDE47833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47833">
        <property type="protein sequence ID" value="CDE47833"/>
        <property type="gene ID" value="BN770_01382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="187" mass="21576" checksum="1071465DBF274839" modified="2013-07-24" version="1">MPKVESNAAIEALEKKKMNAAHWCVASLAIGLVGGMAPVFLMPWDDPWSTVVLGIFVITMMIGLIGNAVRIVKYDLQQKMCRVDMAKGASRRNAAPNEMVLTDGFLRYRIRRQGEVCFLRVEAYDMAADDWREEEPEQRFASRLKLRDYMREKDYVPAEADWDKMSDAAFLQWWREYEKTSARAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9G3</accession>
    <name>R7I9G3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000111">
        <property type="protein sequence ID" value="CDE48524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48524">
        <property type="protein sequence ID" value="CDE48524"/>
        <property type="gene ID" value="BN770_01720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447715" evidence="1">
        <location>
            <begin position="25"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="469" mass="52046" checksum="19D8771C875FD4E5" modified="2013-07-24" version="1">MKKFAALLLALTMVLGMATITASAEGSERVITIGTTWDLYWDSFDGSIEDNPYYSGTTADEMMFAKVKQIEEKWNVKFEYINLTYAGAKESINTSVLAGTPDVDVYMLDLALAAPAAANGYVTDLRDVLPANNAVIQGTDAVLSYIDTGSGAVQLLCANNAENMVGSTMPLGFNLQMIEDANLEDPRDLVERGEWTWEKFREYCKVLTKDTDGDGNIDVYGFGGWPGDYFMNFVMSNGTNVAATATENLSSPEVGEVLQFIQDLNLVDKVMYPIPEENGWDVCRGLYRDGKVAFTPIAAWIMDSNKDYAFQSPDSPTLDFDMVFIPWPVGPHGNAETNAQKVTANSCYVIPVGVEDPELVYNVLYDLLNWYNYDPNSEDGGAAALAIRDDPETLGWWYGVTAKDIDLQDYNFEIMMEMGRHQMLDNYSNLGSDAELPLREFINGDYTTAQLQEKYRQTIQDAIDGILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9J7</accession>
    <name>R7I9J7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000113">
        <property type="protein sequence ID" value="CDE48564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48564">
        <property type="protein sequence ID" value="CDE48564"/>
        <property type="gene ID" value="BN770_00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="45" mass="5011" checksum="5F0336688BB7F499" modified="2013-07-24" version="1">MNQEKIGKFIASCRKEQGFTQTVLAEKLGITDRAVSKWETGVSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9N0</accession>
    <name>R7I9N0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YibE/F family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48285">
        <property type="protein sequence ID" value="CDE48285"/>
        <property type="gene ID" value="BN770_01618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="200" mass="21245" checksum="D0A58C5D39D6AA07" modified="2013-07-24" version="1">MASFVTVIVLTVLIDVLVAGFSRRCLTAILGSVAGTVVTCLSAWGLTILLKLDGGDLPYVVPLLSQSAMQVDTRSLYIGMMLLANSGALMDLSMEEVHRHKPDISRRALMKSGLLVGRSVLGTMTTTLMLAYSGNYLSMLMYFAGQGTPLMDIINLKYVASQLLNTLVGSFGLAAAAPLTALIATGMYLQKPKPAELRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9U5</accession>
    <name>R7I9U5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000091">
        <property type="protein sequence ID" value="CDE48231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48231">
        <property type="protein sequence ID" value="CDE48231"/>
        <property type="gene ID" value="BN770_01586"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="63" mass="6391" checksum="02313851D2389264" modified="2013-07-24" version="1">MPGNILDVKVKVGDTVKAGTVLCVLEAMKMENEIPAPKDGKVAQVVVTKGATVGAGDTLVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9X2</accession>
    <name>R7I9X2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kojibiose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48256">
        <property type="protein sequence ID" value="CDE48256"/>
        <property type="gene ID" value="BN770_01603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="6">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="322"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="5">
        <location>
            <begin position="704"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="357"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="596"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="764" mass="86482" checksum="EFE1EACD93766144" modified="2013-07-24" version="1">MAKAADVYFQVDPWKVIEQGFDPAYARVSESIFSLGNESIGVRGCFDEGGHVDSLRGAYTNGIYDMEKLSRSYKGIIDKTHFMIPSAEWLMTTISVDGETLDLGQSQFSDFTRELDLRAGTLTRRFLWTTKSGKQIRLTFLRFLDMVHRERAYQRITLEALTFTGSATVTSGVSFDVVHEGRQKCFWQETRINATPDCLMAQSHTTLSNQEEFCGAWLTLPGESTTSAEGKTVTATADVLLAPGQTVQIDKRAVVLFNGQQGDDLWQSGQDAMAQSKAVSLDDAQAAQRAYWDAYWHTSDICIEPKDESMAEAVAAEQQGIRFCSFQLAQTYNGGSMRHNIGAKGLTGEAYNGHAFWDTESCCLPFYLFTNPEAAKSLLLFRYNTLPMALERAKMLDCKGACYPIATLNGDEACPLWQHASLQLQPSTAVSYGIWHYVHLTDDKTFLYRYGAEMLLQIARFQATRVGFSEKIGKYGFFGVMGPDEFHMMVNNNAYTNYMGMRALRYAADVLDAMRADAPEAYAALCEKVELAPDEPAQWRHIADNMYIPETSDHLFEQHDGFFELPHTDINSIPVSEFPLYDHWAYDRIYRTDMIKQPDVLMFLYLYNSSFDTETKRINYDFYQPRTIHESSLSPAIHSILAAELDKMDEAVSFFGYATRLDLDNYNRNTREGLHITSIAMAWANIVYGFAGLRSDDTMLRFAPRLPERWKRLTFSVMYRGRVIAISMGADKTVFQLMQGDKLAVQVYGETVELTDEPISVQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9Z1</accession>
    <name>R7I9Z1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48118">
        <property type="protein sequence ID" value="CDE48118"/>
        <property type="gene ID" value="BN770_01538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="508" mass="55582" checksum="4A93408D9EE1BF91" modified="2013-07-24" version="1">MQRIALDENVLQFVLHRLFGGHANRVERGFRRVQVKVVVAVNAGDFLDDIRLDGYVLRRAPGGDVRGEGIAVPRHAEAQRGQRVHDFVGGNVDAGIAVNKRLVKGQLHLRIVEGVLVGQAGGDAHFRIVFLQKLDEAGDGDGRHFRVKALFVAGGGVGAVGEADAALADGRRVERGGFQRQARRVIDDFAVQTAHDARDGNRLVAVADHQRVRVDGALHLVQRLEREALREAADADFLHLAAVEGVHRLPHFQHQVVRQVGEEVDVAHTAVVQADTHRHRADVAVDVLHPQAGVALAQRVFNLHVDGGQIVVRRQIRHGQGFQRTAGQGGEFARHAVVPPQVGAVRQGLVVHLEDNIVNGVERLQIRAAGNILREDHDAGIVVADADFLLRAAHAVGRVPGELARADGDVAQLRAHLRERGFHAQLHVRRAADHVGQLPVARVHLQQVQLVGFGVIFYADDLRGDNAGQIRALVENFILNFRRGQGELANQRHFVKTRQVNEVGNPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA48</accession>
    <name>R7IA48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48475">
        <property type="protein sequence ID" value="CDE48475"/>
        <property type="gene ID" value="BN770_01713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="108"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="310" mass="35228" checksum="D9E40F060D536DE1" modified="2013-07-24" version="1">MAERRGQVAVKDLPPKLQKKLRRQKIMPKKARKLNRSMAGNALLFTLMFICGIFMALPLVMIINNALKPLDELYQFPPKIFVRNPNLRNFSDLFILMNDSWVPFSRYIMNTIIITVAGMVGHVIVASWAAYPLAKDKFPGKALLFGMVVLSMMFNWTVTQIPQYAIISWLHINNTYLALILPAWSFGMGLYLMKQFMEQLPDSLMESARVQGANEWQIFWKIVMPNVKPAWLTLAIFQFQQMWGNTGSLFLRDEQLKPMQYALQQITAGGVSRAGAAAAVTFIIMAVPVLFFLLCQSSILETMTTSGMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAH7</accession>
    <name>R7IAH7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48595">
        <property type="protein sequence ID" value="CDE48595"/>
        <property type="gene ID" value="BN770_01738"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="277" mass="30407" checksum="984D9919F5A5E4B8" modified="2013-07-24" version="1">MTNTTLMQRFQAAAETIRQRVGEAEIGVILGSGLGDYVDALQDAKYIDYKDIPGFPVSTAPGHAGRWWTGTLHGQRVCMMQGRFHYYEGYDLQDVTMPVRVMALLGVKTLVVTNAAGGVNLNFAQGCLMMLTDFINMSGHNPLTGRNLAEFGTRFPDMTHAYDVQLMEKCRQAAKALGIPLQEGVYMWMNGPTYETPAEIRMARILGADAVGMSTVPETIVARHCGIRVLGVSCITNMAAGIIDQPLDEQEVIETAARVKGTFRALLDETIRRIGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAM3</accession>
    <name>R7IAM3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine synthase</fullName>
            <ecNumber evidence="6">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BN770_01648</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48323">
        <property type="protein sequence ID" value="CDE48323"/>
        <property type="gene ID" value="BN770_01648"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017215">
        <property type="entry name" value="MetH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037472">
        <property type="entry name" value="DHPS_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14 19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="20">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="21">
        <location>
            <begin position="304"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="23">
        <location>
            <begin position="580"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="22">
        <location>
            <begin position="675"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDE48323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="794" mass="84192" checksum="D2B9AD42F6A103D8" modified="2013-07-24" version="1">MEHKLTFLDGAMGTMLQRHGLKLGEIPELLAITNPDLLTNIHRQYIEACTEIVYANTFGANRRKMQKTPYTVADVVSAAISAAKKACIGTSARVALDIGPLGELLEPMGTLPFETAVDMFAEIVDAGVNAGADLICIETMTDLYEAKAALLAAKEHSTLPVWVTMSFDATGRTFTGCTIPSMARTLEGLGADAIGLNCSQGPKQLLPLFQELCRVTTLPVIAKPNAGLPDPVDGHYDLPPEEFARTMVDVVGAGVSIVGGCCGTNPDYIRALHDAVHTMTPGARDIHHGSFLCTPTMPLEISGVRVIGERINPTGKKRFQQALLAGDLDYIVDVAIAQVDAGAQILDVNVGYPGVDEVAMLPRVVKKLQEAVDVPLQLDSTNAAALEAALRVYNGKAAVNSVNGEEKALQTLLPVVKKYGAAVVGLALDEKGLPKTAAERVAIAKRIVAAAESFGIPREDVFIDCLTLTVSAQQDQAEETLAAVRTVHRDMGLQTVLGVSNISFGLPNRLLMTQTFLVRAMNEGLTLPIINPNQKEIMDAVAAFRVLSGEDEACAAYVERFGSEAALAAEKQRAAAVSSAPTAKAAAAAVTNLDDAIIRGLKADAARLAKEALATENELSLVEKHLIPALDKVGTDYERGVAFLPQLLGAAQAAQAVFSVIRDSLAAKGGEPVKKGRIVIATVKGDIHDIGKNIVRTVLENYGYDVLDLGRDVPPETVVDAVVKENIRLVGLSALMTTTLPSMEETVRQLHTLPNPPSIMVGGAVVTPEYAQKMGAFYAKDARASVEIAKKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB80</accession>
    <name>R7IB80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47742">
        <property type="protein sequence ID" value="CDE47742"/>
        <property type="gene ID" value="BN770_01329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="302" mass="33113" checksum="1BB00D4B101D0EA2" modified="2013-07-24" version="1">MTTVQTKVLMPEKKKKVTLAQVILVTIIMLFVLICVLPIINVASVSLSSKSAILRGDVAFLPVEPTINAYKAIVRDASMIRSLFYTIELTVIYTAMAMVMTILLAYPMTKKRLRGRRLLSLFVIFTMYFNGGAIPTYLTIKNYGLINSMWSLILPGLISTYNMIILRSFISALPGELEEAAIIDGATDFQVLLKVILPLTLPAIATLSLFYAVGKWNSFSDALYYISSASLQPLQLKLYNLIKGSTTLDISAVEGNSADLGHSISESIESASIIFATLPILVVYPFLQRYFVSGVTVGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBB8</accession>
    <name>R7IBB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48761">
        <property type="protein sequence ID" value="CDE48761"/>
        <property type="gene ID" value="BN770_01814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="848" mass="93559" checksum="9E1A772C78D7BD38" modified="2013-07-24" version="1">MSDKLKRVLDTNLAGLHVTDAQVNAVLRRVSQDEQRPRVIRWQAIAAVLLVLVLGAGVLLQTGILSDDSPQLTADVTRQGDFLTAAQVKKLLASAADLQFSVDEEAISALMTQVEKDGGCSLSTLLEILCPAGSSLGQWDIRAQVALSQTLERIGYQGILPGMTREPLSTEITAQDALARAVAYIRTNDDPQADFTNLDFYRVGIRFLSGVYDGTCEGAYYCANFDALDAFGTTYEVAVNAEDGSICRMRRERGAGSNHTADEVTRGFRRIFGYDMRTWTPMQLRVYILALSRADHSSMQTVHELFLSVGRDGFPDVPAEALNREEAIDAALAIQGGSSSDVLAAEYLAGASGDFWKIAIRQPNAPSGQSIVYLELNGLTGTLLTTTYSGNLYGLPQEFFPSQLLSTLDRTDFSHGVPAVDAETAQSAASDAIQRQYQRNMAEEGYTCFIESDFEDTAGGFSYYTGGGVVIFSKDAQNTSQGDIYWAALNWYGEVLDVGWNRNPLDAARFTLLMQGYLPPIYQRETVQQLQALLTGSQTDEAGLRQMETDGTLPLFNALLALEVVPDASTKSTADDVTAAALKSLNAHLCYENSSFLVYREDGELIWHFWLSTDMGYFLLDVRDSDLSVVGSVQIPSFSALRASILLPVRVWNTLAENLRVTSFYRDANTQPGIVYGMYANHIVQRYVDLYGANILRWDQATLRSFQSAISISGSYVGDWSVACLCQTIYPDVPDYAISQEVAAEYAARALGDDDYSLRGGVLIDPGEGDPIWKVTLDYPDGRSFNAEVDCRTGAIRTLRQQDTRLMPFYTDYLDFPDDGEYWFRNFVLDEVIEQVRTQMTGRYGNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBC7</accession>
    <name>R7IBC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000064">
        <property type="protein sequence ID" value="CDE47797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47797">
        <property type="protein sequence ID" value="CDE47797"/>
        <property type="gene ID" value="BN770_01361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="192" mass="21079" checksum="EC9B5EDB708DDFE8" modified="2013-07-24" version="1">MDKKRKDSVIRATVDRAALLRGVLMLTALALLLCFGLKPSRAAAPDAEDGALTASDASARLSAECELLQRVTFSPCGHEMTRRQRLPAELAGMTKDELAAKYDQWVITSFSPAQVSMERALALYCPEHVVLMPDESGQLCIFRNRYGDALALVHELGVPLSDLPDDVQEDVRAGMGFDDEVTLEKWLESVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBF8</accession>
    <name>R7IBF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48643">
        <property type="protein sequence ID" value="CDE48643"/>
        <property type="gene ID" value="BN770_01764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435726" evidence="1">
        <location>
            <begin position="22"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="43"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="34155" checksum="400D7B4C8BC5BBA6" modified="2013-07-24" version="1">MKKQLLAALLLLTLLLPFASAEEKTEAEQALPMLELHQVNLGCADGYLIRFGNTTVLIDGGEAWPNKPERLFPQYLEAVGVTHVDAYIVTHWHLDHCMNVNYILERWGGGSTVVYGASAEVNPDYAPLANGTIYQQMKEGDELTIGGWLTVNCVGPETVKNNGNQNMDSLNFVLIYGQKRMLFTGDYAASGNINRKYQDLVRNIDVLKFPHHGILDDKTNTYEIGVVLMRVLSPTYVLIPGAASVWEIWNFIAAYSAEQNLTRDHVYNNRFGNIVLLTDGETIEVCTNVDPADFNPYQPSREVTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBJ6</accession>
    <name>R7IBJ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000068">
        <property type="protein sequence ID" value="CDE47877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47877">
        <property type="protein sequence ID" value="CDE47877"/>
        <property type="gene ID" value="BN770_00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="73" mass="8612" checksum="A564EBD50E609CD4" modified="2013-07-24" version="1">MRRLIYTTNASEGFNRQLRKVTKAKSVFPTDDSLLKMLYLAMTDITKKWTGRRQDWSMIHAQLAVFFADRMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBQ6</accession>
    <name>R7IBQ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49319">
        <property type="protein sequence ID" value="CDE49319"/>
        <property type="gene ID" value="BN770_01969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435683" evidence="2">
        <location>
            <begin position="35"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="338" mass="37318" checksum="9E6637510D85F08D" modified="2013-07-24" version="1">MQKKHMERCLFTLLVLLIFTLTILGLYRVTKHSAAPASTTIPVVSPAASPADDPTATSSPTPNPVPSPTPAPPDRVDSYAVQGIEVASHQSDTMHWRIERIEQEGAVCYLTKIYLLDPGTQIRKATANWERDIQYPVDMAAKIPDATLFINGSGYVSPTFPEIPSNYPGSSPDYYYTPLGSVTVTDGQVFRCLTGVPYYGLSLTRDGLHMHVGDDPADVLAANPTQTWSFYIECPVIRDHQSILDPNWRFTTAPAMRTIISCIDEHNFILLTVTRDSSSALTMRQCVDYLQSAFDPLWTYNLDGGPSIALYYRLSPDDDWVRVAGGTSKDADIMAFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBR9</accession>
    <name>R7IBR9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage V sporulation protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47957">
        <property type="protein sequence ID" value="CDE47957"/>
        <property type="gene ID" value="BN770_01457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="577"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="642"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="705" mass="76520" checksum="9F8087A476AA7638" modified="2013-07-24" version="1">MHPELLVRKRIWLMTLMLTGLFLLAAARIAVLTTSEAASLTERGIRQWTKAGIVTARRGTITDRKGRTLAISATAYIVTADPRLVSNTEKFLDSIEPVLNINKEAARKRLQDKTKGSIILKRQVSRETVDALRQLRSDAPEDSGLKALSFDEDICRYYPYGALLSQVLGLTTVDSEGQSGLESRYEDVLRGTEGSYLRQVDARNRQLDGTEGWYIPSQQGCGLVLTIDAEIQEMVEKAMRECIEVNQAQSVICLVSDVKTGAILAMCMNPCYDPNDPPRNDAETLTELMRLTAISDVYEPGSTFKILTAASALDSGVTTPQDSFYCSAKITVDGDTIRCWGRPHGAETMADGLKNSCNPVFVELALRMGTDTFYRYLTAFGLGKKTGIDLPGESPGILITSRNVKRVDLARIGFGQSVALTPIQMMMAANSVINGGKLMKPYIVSEIQTPDGETLERFHPTVMAAPIRPETSDTMRLLLERVVSEGGGKNAAIAGYRIGGKTGTAQVYKNGRVVRDTHIGSFYGFAPVNDPQVSILVIVKEADVPIDYGGTTAAPFARQIMQEMLPYLGIDPENDEKDEEIEVPALKGLTIGDAKRKLSQVGLESVTDGANTVVLDQLPPAGAKLVKGGHVMLYTAGSEELTPEELVCVPDLTGLGDVDCARLVRQRGLMMSMTGQGLCIEQSPAAGEYVQPGTTIFLLMAGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBS8</accession>
    <name>R7IBS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48733">
        <property type="protein sequence ID" value="CDE48733"/>
        <property type="gene ID" value="BN770_01795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="347" mass="40413" checksum="81EE3592253CA368" modified="2013-07-24" version="1">MSVKMPKPVSKTELSRLYTRLAIDTHHRLDNSTAEGQARLDLLHRFFDACANLYGTMTLWHAWELFQHVEPELTAKKKILRKDFFSFAEIVRVEKHAYAIMLLPDLYEEETSISIQDAELVHRMLIYPNIWGLNEYYKLLSYQDDKPCVVPAHDVFYAYADPNYFWETPEARSLRFFLANLHVAPDAKTTAPDGTPLRGKALSEVVFWTKDDHWDYDDYKAAWRKKAVSEEANRPYLQRIMEKIQRGILLSFVCDQFSYYVELLEEAGIQFTKPQFETFANRLCELNNHSHLWSTCGGQPVEMYDGLDNAELDAAALMKTMQLDPDGYYRNPVLSRITPKKNEDGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC56</accession>
    <name>R7IC56_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48087">
        <property type="protein sequence ID" value="CDE48087"/>
        <property type="gene ID" value="BN770_01535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="336"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="583" mass="66093" checksum="0779C2A0D6EC7EC5" modified="2013-07-24" version="1">MENIKWLWGVMDKRYHKWHILGLIISAITSLMLLINPYLTMRLMDDVIVAQNPEPLVGLLLTMLIVKVTREGLRYLMVVLLEHSSQNTLMNLRMRLFTRLQYQDMRFFDIHRTGDLMTRLSADTDWCRHFLAYIDYVAVDSIVMFVSSSIYLFSVNWKLALAMVCVTPLLMIITKVYSRGARRMFVDMRDKMSDMNAKAQENIAANRVVKAFAREEYEENRFDERSRAFRDANLDINKRWLSFYPFIEILANAMTLLTVFFGGYLMITDGMTAGELTIFTQLAWTLSVPMRQLGNLLNDWQRFITCSNKVMEIEVSRPEIVDSSCAVNHDHIEGAISFDHVSFAYGSQPVLSDVTFSAKPGQTVAIMGPTGSGKTTLIQLLARCYDVTSGSISVDGCNVRKWKLQQLRDGIGTATQDVFLFSDTVEGNIAFGDQTLTEDEVHDFARRAAADDFIKGLSEGYDTIIGERGVGLSGGQKQRIALARALAVKPGILVMDDTTSAVDMETEKYIQAQLRQLPYDCTKLIIAQRISSVKDADLILILKDGVVTERGTHQELLRQRGYYYETYCLQNGITPDTAPQEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICN8</accession>
    <name>R7ICN8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49375">
        <property type="protein sequence ID" value="CDE49375"/>
        <property type="gene ID" value="BN770_01988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="193" mass="21011" checksum="D50EF5E877F45221" modified="2013-07-24" version="1">MENQESIYEEKQGNLLTGILGALLGALIGTALWVLVGVWGYIAGIVAWLTAFLAGKGYDLLHGRPGKAKAITIIVMLILSICVGTVGTATVIMVQSYNQQISEMNTFEQARIQKYGPTVEEYVQSMFMEQDVQTEIVKNLAVGMLFGALGAYPIVLGNRRKKQRQDTVQPYEAADGAPKSTENADDTDKHLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDB3</accession>
    <name>R7IDB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium and cobalt transport protein corA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49635">
        <property type="protein sequence ID" value="CDE49635"/>
        <property type="gene ID" value="BN770_02063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="36170" checksum="675501E2E7E2B158" modified="2013-07-24" version="1">MRRIFKTIEDHLTECTTLEKGVWVHLQSPTKEEVDGLTTRFNLDPTFLPAALDEEESARIDYDSDKQQTLIIVDIPYVDTEGTGYVYSTIPLGIVLCDEVIITVCTRDTPIINDFTEERIRNFWTFKRTRFILQILQRNAGRFLSYLKQIDKTSQHIQEKLEHTSRNQELLQMMKLEKSLVYFNTSLKGNALVMERLMRQDILKRYPEDTDLLEDVIIENKQAMEMCSIYRDIMSNTTDAFASIINNNLNITMKVLTALTVLFAVPTLVMTIWGINVPVPFERQAWGFAAVCGISIILTLFAFVIMRRKNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDB8</accession>
    <name>R7IDB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49640">
        <property type="protein sequence ID" value="CDE49640"/>
        <property type="gene ID" value="BN770_02068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436425" evidence="1">
        <location>
            <begin position="27"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="479" mass="52327" checksum="3C9966288F443F57" modified="2013-07-24" version="1">MKKFLSLLMALTMLMACTACFGSAESASDPAAYDGSEVNITFYNTMGSNLTPVLDTYIEEFNKLYPNIHVSYTSVGGYDDVRDQISKEITVGGQPNIAYCYPDHVALYNLARAVQPLDAYIDSTATITRADGTTETFGLTQEQKDDFISAYYEEGRQFGDGKMYTLPMSKSTEVLYYNKTFFDANGLTPPTTWDEMEALCNKIVEIDPYSIPLGYDSENNWFITMTEQLKTPYTSATGEHFLFSTPENRAFVKRFATWYNQGLVTTQTIYGSYTSGLFVSDSGIKSYMSIGSSAGATHQRPTKGADGNYPFEVGITTIPQVDASNAKVISQGPSLCIFKKSNAQEVAASWLFVKYLTTTVDFQAEFSMASGYVPVIKSVANNEVYAEFVAGADGGDNVAALAAKVCLEQVDAYYTSPAFPGSSEARSRVGELMAGCMTDAAALGDLTKPENDAKLDELIQKRFDEAITKCEQSIAGFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDH6</accession>
    <name>R7IDH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoribosylformylglycinamidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000153">
        <property type="protein sequence ID" value="CDE49864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49864">
        <property type="protein sequence ID" value="CDE49864"/>
        <property type="gene ID" value="BN770_02173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010141">
        <property type="entry name" value="FGAM_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01857">
        <property type="entry name" value="FGAM-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="5">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="375"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1168" mass="127065" checksum="FAFFA661AC584366" modified="2013-07-24" version="1">MFSEPQVDVMYTELPHGAKAVFAVEYLPGQYDQRAASCEECIQLVGQCARPTVRSARVYLLDGDFTADELARVKKHVINPVEAREADLGEKTTLQQQYDTPDHVETLTGFTAMNADEVDAFVKKYGLAMDDDDLAFCRDYFASEHRDPTLTEIRMIDTYWSDHCRHTTFLTTLDAVDVRKAAVEKAFQRYLAARKTVYGDRERPMNLMDIATIGGKYLKKIGQTPNIDVSEEINACSIKIDVDVDGVKEPWLLMFKNETHNHPTEIEPFGGAATCIGGAIRDPLSGRTYVYQAMRVTGAADPLVPVSQTMPGKLPQRKLVTTAAAGYSSYGNQIGLATGLVDEMYHPGYAAKRLEIGAVVGAAPEKNVRREVPAPGDKIVLLGGRTGRDGCGGATGSSKSHKLESIETCGAEVQKGNAPTERKLQRLFRDGEVTRLIKRCNDFGAGGVSVAIGELADGLMIDLDKVPKKYDGLDGTELAISESQERMAVVLAPEDVDAFLAAANRENLEATVVAEVTAEPRLRMTWKGVTIVDLSREFLNSNGAEKHTTASVPDDDVKPYEFAGDTVTEKLADMLGNLNICSKQGLSERFDSTIGAATVLMPFGGKYQLTPNQTMVAKLPVLHGTTDTVSGMAYGMHPEILSQSPYEGSYLAVIESVTKLVCAGFDYKQAYLTFQEYFERMGTDPTRWGKPFAALLGALDAQLDLNIAAIGGKDSMSGTFEKMDVPPTLCSFAIAPGKASEVISPEFKEAGHAIRLVSCDPHDTAALTADYDAVLSAIRAGKVVSAWALGLGGVAEGLFKMGIGNQIGTRIDDDYDGNLFAQQIGAMLLECTEDIDLGVKVGDTVPEWVLEYEGERIDLTAMQEIYEGKLDKVFSYRGHTGETTEKFSYSAETYPVPAVKTVKPLAFIPVFPGTNCEYDTARAVERAGGAAEILVINNLTPEAITQSIAEASRMIARSQMIVLPGGFSGGDEPDGSAKFITAFFRNPAMKDAVHDLLQRRDGLMLGICNGFQALIKLGLVPYGEIIDTSDQCPTLTFNEIGRHQSMLVRTRIASNKSPWLFRCKVEDIHTVAISHGEGRFVGPEALIRQLAANGQIATQYVDLSGAPSMDMRFNPNASYFAIEGITSPDGRVLGKMGHTERSGENLYKNVPGDKYQPLFESGVDYFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDN4</accession>
    <name>R7IDN4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49929">
        <property type="protein sequence ID" value="CDE49929"/>
        <property type="gene ID" value="BN770_02191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="230"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="411" mass="45927" checksum="269147A89FB1F6C8" modified="2013-07-24" version="1">MKILLVNKYFNMHGGSETYFFGLADLLRQAGHEVIFFAMQDEKNLPCEQSAYFVSNVEFNGELTAAQKLKAAFRMVYSFEAKKKISALIEKEKPDIIHINLFHRVLTASIVDAAKKHGIPVVLTMHDLNCVCPNHVMLDHGKICEACLHGNYWNCVKRVCFKDSRAKCLMAAIESDFNKRSGLYRKIDLFITPSECYKNKLEASGLTKSPIVHMKNFLPADTKYAVQGKRGDYVLYYGRLSAEKGILTLVRAMEKLENVPLIIVGTGPEEDAIRAEIEAHHLNQRVTMVGFQSGENLWQYVRNCACVVVPSEWYEASGYTACEAQAMGKPVVATNAGGLPENIVDGETGFISPMKDEAALANAIGRVMRLSDEEYQRMAEKSVANAKKLFDASGYVAKLLVLYANLKRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDT9</accession>
    <name>R7IDT9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG nucleotide pyrophosphohydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49765">
        <property type="protein sequence ID" value="CDE49765"/>
        <property type="gene ID" value="BN770_02123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11541">
        <property type="entry name" value="NTP-PPase_u4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011379">
        <property type="entry name" value="MazG-related_GP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006639">
        <property type="entry name" value="UCP006639_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="110" mass="12301" checksum="8E4D0CA1E83C0F61" modified="2013-07-24" version="1">MNVDDYQQEAMSLLNPALNPQDVLENALMGLCGESGEAIDLLKKHRFQGHPLDKEKLKKELGDVAWYLAEAAQGLNVPLSEILQGNLNKLHGRYPNGFSSERSMHRENAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDX9</accession>
    <name>R7IDX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48757">
        <property type="protein sequence ID" value="CDE48757"/>
        <property type="gene ID" value="BN770_01811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32322" checksum="9056C58ACE0D3521" modified="2013-07-24" version="1">MNTDRIAYFLAVVREGSFSAAAKNMYVSQTAISQQIASLEKEMGCALFHRLSTGAVLTDQGEQFLPYAERLMGIQLELQDAFADAHRVSAIHIGYNGPLEKELIVDAYLSLHPHLPNLVIHPLYLSLTAMSDALYRGQCDMVLTLPGEIDQRNTYQEVLYDVPMIAAVSEASPLAEKSIVSLSDLRAYPLILLAPDQSRSGRGAIHDWAQNLGFPNQSIIYADSADMQILMVSLNLGISFFPARKPAYFKGVKLIPLTEDIGHHRSVLVCRRLTPAIRMIRDCMIEEMKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEB9</accession>
    <name>R7IEB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48927">
        <property type="protein sequence ID" value="CDE48927"/>
        <property type="gene ID" value="BN770_01866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="8">
        <location>
            <begin position="231"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="389" mass="42128" checksum="3B826A43C0BBD2AB" modified="2013-07-24" version="1">MMRLAQRLIRPGESPSDQPVRKRLGTFASAVGIGTNILLSLTKVIIGTLTGSLAVTADAVNNLSDAAGSIVSLISVRVAQKPIDREHPFGHGRIEYLGALGVGALILVMGLELLKSGVSGIITPQAMRFAWVPFLILLFSIAVKGALFFFYRDAGRLIDADSLKAASRDSLSDVLATSAVALSMVIGQFTAFPVDGVMSIIVALLVLKTGFDVVRDQMDTLMGAKTNPELGRQIIAMLNQYDEILGTHDLMIHDYGPGRCVASIHAEVPADANLVAIHEVIDRAESDISRALHIPICIHIDPIVVGDPIFDSITAHFNHILTQQYPGTHIHDLRMVPGENVVNLVFDVAVPPECKDTAPLTEQLSRAAKALDPRYRCVIHYDLDFYNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEI7</accession>
    <name>R7IEI7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tex-like protein N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000165">
        <property type="protein sequence ID" value="CDE50224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50224">
        <property type="protein sequence ID" value="CDE50224"/>
        <property type="gene ID" value="BN770_02327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="643"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="733" mass="80533" checksum="A62DF0533720DF79" modified="2013-07-24" version="1">MTITQTLCQEFQTAPWQIDAVIRLLDEGCTLPFIARYRKEQHGSLDDQKLREISERLTALRALEARRQEISESLQKLDVWTEKLQSDLDAAATLAQLEDIYRPYRPKRRTRASIAKEKGLEPLANALMLQQRNMMAPETIALRYVNAEKGVETAEDALQGAMDIIAEVVSDDAAVRTKLKTYYHQTAMVATVAAKDEDSTYRMYYDHREPLRLMPSHRVLAMNRGEKEGFLKVALDVDKEKAQQLVRYGFVQQTGSPACKYVAQACDDAYTRLIAPSLDTELRAELTDKASAAAIRVFALNLRPLLMQPPVRGKVAMGLDPGIRTGCKVAVVDETGRVLDTGVIFPLPSHGKVAQAKETVKRMIQKHHVGIVAIGNGTAGRETEQFFVEVMKELALGDALKYMVVSEAGASVYSASKLAAEEFPQFDVSLRSAVSIARRLQDPLAELVKIDPKAIGVGQYQHDLKAAELDAALGGVVEDCVNSVGVDVNTASVSLLSYVAGINTTVAKNIVAYREENGAFTTRAQLKKVPRLGPKAFEQCAGFLRIPGGKDLIENTGVHPESYDAARALLKHFSLTPAEAVGKLLTLADAEGFAALAKQLNVGEPTLRDIAAELSRPGRDPRDELPQVLMRSDVMDLKDLQPGMELRGTVRNVTDFGAFVDIGVHRDGLVHISQMAQRRVNHPSEVVRVGDIVTVWVLEADAKTNRISLTMRPPAKGEGNFSTTKSTQTKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEP9</accession>
    <name>R7IEP9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49916">
        <property type="protein sequence ID" value="CDE49916"/>
        <property type="gene ID" value="BN770_02186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="298" mass="33436" checksum="79AB1A84BA7B2DE5" modified="2013-07-24" version="1">MKGIILAGGSGTRLYPLTKVTSKQLLPVYDKPMIYYPMSVLMNAGIRDILIISTPQDTPRFENLLGDGRQFGVHLTYAVQPSPDGLAQAFIIGEDFIGSDSVAMVLGDNIFSGHGLNKRLHAAVRNAENGRGATVFGYYVDDPERFGVVEFDKAGKAISIEEKPAHPKSNYCVTGLYFYDNRVVEFAKNLKPSARGELEITDLNRIYLEDGSLNVELLGQGFTWLDTGTHESLVDATNFVKTVEQHQHRKIGCLEEIAYLNGWISKEELMEVYEVMKKNQYGQYLKDVMDGKYQERLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF19</accession>
    <name>R7IF19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49923">
        <property type="protein sequence ID" value="CDE49923"/>
        <property type="gene ID" value="BN770_02188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="413" mass="45759" checksum="A6F702EDB2278E4B" modified="2013-07-24" version="1">MRYFRNPNFISFCFLILIKPGCISGIPALGILDTLLNMIRIMLVLFTLIVLFKNAQLLPVNRLFGVTMLVVASILWEPISTLTGGGSIADFGALMNDLGIALVCYIGLRAGYDSFIEGVAKVSGAYVLINCLTVILFPAGMYATTKYSQNFFLSYRTAWFVIYLLALTTTLLWNANVGSRFTKRFAIAVAVAATLSMILQWTATGLFCFSIGGLVLLYCTWKKRNPFKISTVMLTEAAAFWAIVIARLMDMFSFLLVNILHKDVTLTFRTRIWDNALAAIQQNLLTGVGRLDAAQMEAILGYGVSHPHNRYLYVTLCFGIIGLALFLLIVYYANKGTINPHRVREGRIMMAAFIALLSAAQVESLSATGGYAIPLYLIAAALHCREGRRKEMGEIPQHMLTARGKTTIYSRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF52</accession>
    <name>R7IF52_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Argininosuccinate lyase</fullName>
            <shortName evidence="7">ASAL</shortName>
            <ecNumber evidence="3 7">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argH</name>
        <name evidence="10" type="ORF">BN770_02389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50434">
        <property type="protein sequence ID" value="CDE50434"/>
        <property type="gene ID" value="BN770_02389"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="9">
        <location>
            <begin position="363"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="459" mass="51164" checksum="305FDF37E47600EC" modified="2013-07-24" version="1">MKLWGGRFSKATDGLVDDFHSSISFDQRLAEQDITGSIAHATMLGEQGIIPQEDADKIVEGLRGILADVKAGKVHWMVDAEDIHMNVEALLTERIGEAGKRLHTGRSRNDQVALDCRMYAKLACQETQEMLRELLGVLLDIAQDNLHTIMPGYTHLQKAQPITLAHHMMAYFQMFRRDLDRFAHAYDAADVMPLGSGALAGTTYPLNRERVAELLGFSRISMNSLDGVSDRDFLLEYLSAASICMMHLSRFCEELILWNTNEFRFVEMDDAFATGSSIMPQKKNPDVAELIRGKTGRVYGDLMGLLTTMKGLPLAYNKDMQEDKEAFFDARDTLVKGLTVFTAMLRTVTFRKDVMEKGASGGFTNATDCADYLVKRGVPFRDAHAVVGRLVAHCLNENKALLDLSLEELKQFHPAFEADVFDDLSMLSCVEKRRIPGAPAPDMVQAAIDEGRKSLEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFC0</accession>
    <name>R7IFC0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_02240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50038">
        <property type="protein sequence ID" value="CDE50038"/>
        <property type="gene ID" value="BN770_02240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="190"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="250"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE50038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="473" mass="50932" checksum="679696D1378603DF" modified="2013-07-24" version="1">MSLRWKLMLTFLVVIGASFAIMASILTGMVSSTLYQQRTRQATRSLEQLASSAAPFLASAQMDSLSELLTAQAGELGGRLLAVDMDGKVQADTFGARSGQRLSIPETVAVLLHGEKSAFGIHRVDSESGVSYVAVASAVMEVSGKTRGALVLSLPVDELQSALETVKRQLMTVFLIVAGAAMAAALMLSGMLTRPVKALTQTIRRMGKGDLSARVNVRTSGELKELAESYNAMAEQIEHLDRSRSQFVANASHELKTPLATMKLLLENMLYQPDMPQELRTEFMQDINHEIDRLSGIITDLLTLTQMDSHSSPLRVTKVDLSALTEETVHTLQIAAEQKGQTLAADIAPGITLEGDSGKLMQVFYNLTDNAIKYTPENGHIAVRLAQSGANVLFAVTDDGIGIPEEDQKHIFERFYRVDKARSRATGGTGLGLSIVRQLAAMHGGTVSVSSQPGQGATFTVTLPMDAKRGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFK5</accession>
    <name>R7IFK5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="12" type="ORF">BN770_02448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50589">
        <property type="protein sequence ID" value="CDE50589"/>
        <property type="gene ID" value="BN770_02448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE50589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="222" mass="24702" checksum="D5C9BBBE3F813336" modified="2013-07-24" version="1">MGQKVNPHGARVGVIFGWSTRWYADKKDFANNLVEDFKLRKMIKEKYYAAGISRIDIERTAKDVTVNIMTSKPGMIIGPKGATIEQLKAEVTKQLGRPAQINVMEIKQPDADAQLVAENIAQQLEKRISFRRALKQAQQRAMKLPGVKGIKTSVSGRLGGADIARTEHYHDGSIPLQTLRANIDYGFAEAKTTYGRLGVKVWIYKGQILPKAKKAPVAKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFP5</accession>
    <name>R7IFP5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49397">
        <property type="protein sequence ID" value="CDE49397"/>
        <property type="gene ID" value="BN770_01998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="157" mass="15786" checksum="3B0AE3C1D096CE08" modified="2013-07-24" version="1">MEWGLAIGLFAAAIAAILPGMGSAKAVGLAGETAAGVSAETPEASSKLTLLQLLPATQGIYGFVIAIVIMAKIGIMGGSGAVVPVDKALMLLAAALPIALVGYFSAIAQGKCAAGSMLMVGRRPEMQGKGMMMTAMVETYAVLALLISFLCVNAIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFY4</accession>
    <name>R7IFY4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50356">
        <property type="protein sequence ID" value="CDE50356"/>
        <property type="gene ID" value="BN770_00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="185" mass="21284" checksum="9CEE1A48653E657C" modified="2013-07-24" version="1">MSQTTKRALAQSLKKLLQTKPLSKITINDIAEDCGVSRMTFYYHFADIYDLVEWTCQEDASVALAGNKTYSTWQQGFLNIFHLVLENKTFVLNVYHSISREHLERYLYQLTYDLLIGVVEEKAVGLSVSDRDKAFIANFYKYAFVGLMLNWIREGMKEDPTAIIDRLSVLIHGDITRALHKYSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFY6</accession>
    <name>R7IFY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EDD domain protein DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50535">
        <property type="protein sequence ID" value="CDE50535"/>
        <property type="gene ID" value="BN770_02428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="291" mass="30910" checksum="BA983B33AF7530E3" modified="2013-07-24" version="1">MMKNVAIATDSHSSITPEMAQTLGVAVLPMPFTIDGICYLEEETLTRAEFYAHQRRGAKIATSQPAPADVTALWDNLLTDHDEVVYIPISSGLSGSCQAAMALAADAPYAGRVFVVDNGRVATALHVTVLDALRLRDAGDDAAAIKRKLEAVREDMCIYVAVETLEHLKRGGRISTATALIGTLLHIKPILHFTTGTLSAYKKARGMNRAQDVMIEAIRAELAGRFAEPLAQGRVTLLAASSASPEATAAWKARLKADFPGMKLLSDQLSLGVSCHIGEGGMGVGLSVSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG17</accession>
    <name>R7IG17_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GXGXG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50406">
        <property type="protein sequence ID" value="CDE50406"/>
        <property type="gene ID" value="BN770_02371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXGXG" evidence="1">
        <location>
            <begin position="10"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="241" mass="25837" checksum="0D8031FF6D8DC633" modified="2013-07-24" version="1">MRIVAGDKHFRELNEEINTCPDAEIELDNVCGQRYICSGLSGKKVTIHGIPGNALCCYLDGCDVEVLGNAQDATGDTMNSGTLTIHGHCGDATGYAMRGGTILIEGNVGYRAGIHMKAYQTHIPVLVVGGEAGSFLGEYQAGGYIIVLGLNTRDHAPVGRFPAAGMHGGKIFLRTDCDMPFDIPAQVLSHEADDAEKAEIAPFVRQFAEKFGKDAEAILADRFVVLVPDSANPYRSMYVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG22</accession>
    <name>R7IG22_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50248">
        <property type="protein sequence ID" value="CDE50248"/>
        <property type="gene ID" value="BN770_02333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="153"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="299"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="6">
        <location>
            <begin position="436"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="663" mass="75362" checksum="4F6E485376C7E36E" modified="2013-07-24" version="1">MITMQEMEKELAIYRKNFTAVRLISEADILRTIEARKHNPASRACPCRDGRMTSQGCRNCIVLRAYMEKCKKIKLEYDDPNVYQVTARYLHVEGGRYVLELVQKLDDDMMIDAESGEKLANRLSSYEDKLYHDALTGTLNRRYYEEHMCKTVYEAGIAMIDVDNFKLYNDVFGHRAGDVVLETMAQSVKLHTASGDLLVRLGGDEFLLVMPGIPADRLYSRLLQVSEAVHNTPVPGYTNLQISISIGGVMGNGRLLETAVEQADQLMYQAKTRTNMVMTEMMLAQSSEQENELHARKERILIVDDSELNRALLTEMLEDDYEILEAANGQECMDILNAGSDKISLMLLDLLMPVMDGFEVLASMNRSHMLENLPVIMISSEDSDAFIRRAYEQGVSDYISRPFDAKVVYRRVYNTIKLYAKQRRLVSMVTSQILEKEKNNMLLINILSHVVEFRNGQNGSHVQHMRQLSERLLEMLCAKTDRYRLTPQDCNLIALASSMHDIGKIAIDAKILNKPGKLTPEEFEQMKQHTILGAKMLDDLAAHHNEKLVRTACDICRWHHERYDGHGYPDGLVGDEIPISAQVVSLADVYDALISERVYKPAYSHEQAMAMILNGECGVFNPLLIECLKELQETLRRELEVAPFDAKREKAPGDGKKTVESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG93</accession>
    <name>R7IG93_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyroglutamyl-peptidase I</fullName>
            <ecNumber evidence="6">3.4.19.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50481">
        <property type="protein sequence ID" value="CDE50481"/>
        <property type="gene ID" value="BN770_02413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="189" mass="20083" checksum="35E2BE0F0C47DAEF" modified="2013-07-24" version="1">MSILVTGFEPFGGSSSNASWEAVSLLPETIAGHAVYRMRLPVCYGQAGDLLVEMMRRIRPAVTLCCGVAGGRKAITPELIAVNYRRAAIADNADVLYAGEKIDPKRPDAHMTRLNVLRMVDAMKSAGLPADLSLTAGAYVCNDLYFALLDRGLTVGGEGVFVHVPTEDVVSAVDAAKGLEICLQTTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG96</accession>
    <name>R7IG96_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0297 protein Clo1100_2684</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0297 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000175">
        <property type="protein sequence ID" value="CDE50645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50645">
        <property type="protein sequence ID" value="CDE50645"/>
        <property type="gene ID" value="BN770_02463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009309">
        <property type="entry name" value="IreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40067">
        <property type="entry name" value="PTHR40067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06135">
        <property type="entry name" value="IreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="88" mass="10045" checksum="7DF68C3E57D4DAE9" modified="2013-07-24" version="1">MSQFETTKLHPIQESGNEAQDILLYVYNALQAKGYDPITQLVGYIISGDPTYITSYNSARSMICRLERDEILEELVRFYLAGHTPKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGC9</accession>
    <name>R7IGC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49637">
        <property type="protein sequence ID" value="CDE49637"/>
        <property type="gene ID" value="BN770_02065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="369" mass="41186" checksum="303F05CB5C381591" modified="2013-07-24" version="1">MKIVLQNLTKIFPSRNKKSGEEVVAVNNFDFTIPDGKLIGLLGPSGCGKSTTLYMISGLQKPSSGKIFFGEDDVTDLSTENRGIGLVFQNYALYPHLTVKQNILFPLQNLRGKDKMTKEAMLERAHEAARLVQIEELLERKPSELSGGQQQRVAIARALVKMPRVLLLDEPLSNLDARLRLQTREEIRRIQKETKITTVFVTHDQEEAMSISDMIVVMKSGVVQQIGKPQDVYDNPANLFVANFLGTPPINIFTGHVKGERLFIGVDNVMDVPGVKDQDVFVGIRPEGFILDMANGTLCCKPQNVEVMGRDVSVVSTHEASQKPTVRSIIDADNKVDASADVVRYRIKPHKIFLFTRDDEGVRIPFEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGG3</accession>
    <name>R7IGG3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xylan 1 4-beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49667">
        <property type="protein sequence ID" value="CDE49667"/>
        <property type="gene ID" value="BN770_02085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435870" evidence="2">
        <location>
            <begin position="26"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="114"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="4">
        <location>
            <begin position="438"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="649" mass="70169" checksum="D500584FD5E3FDA8" modified="2013-07-24" version="1">MKKLLKSVAALSLSAMMLLSPGVLAEEDEEESNVVELTTVVQEYEGKQIVLKTAGLDILEQDGYKFKDLNKNGELDPYEDWRLTPEERTEDLLSRMSDKNKAAQMAHMTLVTLKESWFSDLDIGFALTYTYFAESKESAGEKMNYVQSLCEESELGIPVVFSMDSVIGASWINDTTILPDAITLGATGDAELVQELADIQRQEMKALGVRMSLSPNADLATDPRWGRNQETYGEDADTAKAMVVAAITGLQNGTDGIGVDSVMSCVKHFPGSGPQTGGVDGSPLVFDDETFALHLSIFEAALTVHPASIMPYGYSTVPYLGGDAVENYAHESSVVMNDVLRGRLGYDGIIQTDWGLNHIVAMQAGADVMGGMGQRDVTRMVDQVDPSLLTDRCRRLLLAKFRLGVFENPYTDADEIAQVVGSEEHYQKAMEAAEKAVTLVKYENQQPLEGQQILVVGALAKNVDALSSGWKISSETGLKTEGKSIYDAICKRAGADNVTYIGDDETLIADSYPAGTTAIVVVGEASGTHEPAWGTATLEFPAEQQNLLQKLDASGVNVVSVVLMNRAYVMTPVDAASDAVMIVYRPGVTAGAEAVAHALFGDCAIAGKLPWQIPATMDQVMLQREDLPKDIENPLYDYGFGIEVAAFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGH8</accession>
    <name>R7IGH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50428">
        <property type="protein sequence ID" value="CDE50428"/>
        <property type="gene ID" value="BN770_02383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010380">
        <property type="entry name" value="DUF975"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40076">
        <property type="entry name" value="PTHR40076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06161">
        <property type="entry name" value="DUF975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="287" mass="31762" checksum="822191F811E44B85" modified="2013-07-24" version="1">MHTSKEYRQTAWSAIKPVLPIMLLIFLVASLPQLIFMFIQTAFGLMPPMDTDLLLSDPDAFVAAYSAFMSSSKGITYSLLNLLFTLMTIPLTLGTIGAAQRILRGEDVLVRHSLAYIPYTFRAIWLQICTAFYAFWPMLLAYVVAIPVLLTVSSPDIMLLTAILFFIAVIATLVFAIMRTYLMVASDYLLARNPNTSVSEIMRTSRTIMKGNRMNFFLLELSFIGWSLLIAVLDSAVLTMAGYTLANICSMLLSLFLGVYMTTAKAAFVNDLTDAAPSDNASGKMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH10</accession>
    <name>R7IH10_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_02171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CBJB010000153">
        <property type="protein sequence ID" value="CDE49862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49862">
        <property type="protein sequence ID" value="CDE49862"/>
        <property type="gene ID" value="BN770_02171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="370"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="477" mass="53815" checksum="472E301786A5D799" modified="2013-07-24" version="1">MPHDSYISPFSTRYASKEMQFIFSEDNKFRTWRKLWIALAKAEKKQGLDITDEQIAELEAHAENINYDDAQRREKECRHDVMSHVYAYGLQCPKAAGIIHLGATSCYVGDNTDVIIMREGLQVVRRKLLNVMNLLANFADKYKAMPALAYTHLQPAQLTTVGKRATLWLNELYMDYCELEHRLSSLALLGSKGTTGTQASFMELFGGDSAKIKAVEQDIATAMGFDKVVPVSGQTYSRKMDYQVVSVLSGIAQSASKFAYDLRLLANFKEMEEPFEKSQIGSSAMPYKRNPMRCERINALARYVCVDTLNTAMTSSLQFFERTLDDSANKRIAVAEAFLGVDAILNIMMNVCDGLVVYDKVVRARVMNELPFMATENIMMDAVKKGGNRQELHEKLRVHSQAAARVVKEEGGKNDLIDRICADPAFMITREEVEAILRPEQFTGRSCEQVEEYLRDVIRPLLAENADLLGEKQELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH12</accession>
    <name>R7IH12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000183">
        <property type="protein sequence ID" value="CDE50895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50895">
        <property type="protein sequence ID" value="CDE50895"/>
        <property type="gene ID" value="BN770_00240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435930" evidence="2">
        <location>
            <begin position="26"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="254" mass="27841" checksum="DA9D7E7785A0CA03" modified="2013-07-24" version="1">MEKKWFVALLMVVVMVCACWTGAGADEEHKIYTSRDYWYSLLDDGTVEIARYYGNAEKLTIPDTLGGKKVTSIGSGAFLWCDSLTSVIIPDSVTTIGNWAFQKCHSLNNIIIPDSVTTIGNWAFSECDSLTNVTIPDSVTTIGNWAFSECNSLTNVTISDSVSTIGYSTFSNCSALTSITIPDSVITIGDSAFYECDSLTSITIPDSVATIGYHSFDNCPNLTLTVYRNSYALEYAKTNNIPYTYPDANDWLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHE7</accession>
    <name>R7IHE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coagulation factor 5/8 type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000188">
        <property type="protein sequence ID" value="CDE51050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51050">
        <property type="protein sequence ID" value="CDE51050"/>
        <property type="gene ID" value="BN770_00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448283" evidence="1">
        <location>
            <begin position="25"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="52"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="198" mass="21549" checksum="A9AB30060C3904D0" modified="2013-07-24" version="1">MKMRSVVSAMLALSLACLPLLTQAEEEIPTIVTVVPAPDQTKAERPACFPDPADQYIALPETENFALNKEVISGAHTDVYVSRNVNDGKTDTYWESKGFPAEMLIVLGETHTISTVAVCLNPSAIWEARIQEITVLVSKDGENFTEVAPATQYQFDPATGNRIRIDFDSVAASFVKVVFTMNSASRTDGAQAAEICVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHK3</accession>
    <name>R7IHK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein LplB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50778">
        <property type="protein sequence ID" value="CDE50778"/>
        <property type="gene ID" value="BN770_00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="205" mass="22674" checksum="AB2318888844BD53" modified="2013-07-24" version="1">MLNQLNSKRFKGFTQTAIYVPHFISTVVLAGMLYLFFSPTNGIVNKVIEACGGKSIYFMVEENWFRPLFIGSDIWQNAGWNTILYIATLTSIDPQLYEAATIDGATRWQKIRNIDIPHLIPIAVMMLILSCGSLLSSNTDKALLLQTSGNIKTSDIIGVYVYNTGIGKAQYSYTSAIGLCLNVINFVIIISVNAISRKASDISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHL1</accession>
    <name>R7IHL1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50092">
        <property type="protein sequence ID" value="CDE50092"/>
        <property type="gene ID" value="BN770_02269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447987" description="NAGPA domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="2">
        <location>
            <begin position="119"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="324" mass="35949" checksum="764F324218FB7305" modified="2013-07-24" version="1">MKRLISLLLCALLIVPALAEDAPDFEPIPWDIKVSPNLPNPDCYLPNNGGYHDDSIDIQINVTYWTQDLQQVDAPGEGTTTVMSARVKLTDVSQFRTGFANKYPSKQARHVNDMTKRFKAVMGIDGDYCLYHEQGIVVRNGQTLRMRPHKGRDELIVDENGDFHLITCTTQAKWDEYIAGGGTVLHAFCFGPALVVDGVPLTNLDDVTIDNGKAKKAQRMVIGQTGKLEYLILTNEGPESTAPKSVGFDLVQMANLCVQFGLDNAYNLDGGSSSTIALNNQKINSPSSHKNRMVGDCIWFATLVKEETWREKESVRTVKVEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHT8</accession>
    <name>R7IHT8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50157">
        <property type="protein sequence ID" value="CDE50157"/>
        <property type="gene ID" value="BN770_02303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435946" evidence="1">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="183" mass="21503" checksum="B130BD10A209EBD1" modified="2013-07-24" version="1">MKKLLSLMFVLCLLPMFSLAEHSIAANYIYQMILKQVDGTDFTRYDDDYEVMFFYPLSKHTYGDAVVRITAYEDGCTINVSYELPIDEAMMPDVLTFFNYLNNSLYVGKMMLLDIDGDWYPAYEVFMSINPEDIDAWDRGCVMDYTFNAFYVMQEMTDYLPELEKDETPKNVYAMWLSDVWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHV3</accession>
    <name>R7IHV3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000200">
        <property type="protein sequence ID" value="CDE51195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51195">
        <property type="protein sequence ID" value="CDE51195"/>
        <property type="gene ID" value="BN770_00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="147"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34824" checksum="5628D9FE90016267" modified="2013-07-24" version="1">MTIREEIDAQFPIRKTTAQKRAFEKWVMAKMREMGYRPYVDGMNRKDKLRHRNIVAGDPQNAELLISAHYDTAATIGVPDLRIPRNFPVYILAQGAVLLGMLLISLLIGTVVGLATKSGDWLILTFFFAYLALMLLMMFGAANKHNVNDNTSGIAALLETMQRLSPEAREKTAFILFDHQETGSRGAKSYGAQHVEVQTMKLLVDLNCVGEGDTFVISAPKMAQDKPEYAVVRESLEENAMASGVSTQFFGRAGVQGAGDYRRFACGVGVSAYHHSAGVGLITGRIHTSRDTVCRQENLDYLAKSLADAAQKMNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHV8</accession>
    <name>R7IHV8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000201">
        <property type="protein sequence ID" value="CDE51200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51200">
        <property type="protein sequence ID" value="CDE51200"/>
        <property type="gene ID" value="BN770_00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="455" mass="48864" checksum="1FAADA7A466C2EBE" modified="2013-07-24" version="1">MSTAPRRPDLANEPVGRLMLRLSIPTITAQLVNMLYNIVDRIYISYIPDVGTLALTGLGVCLPIILLVSAFAALCASSGAPLASIAMGQRNHEKAEGILGSCTALLLCVSAVLTVVLSCFYTPILLAFGATEDALPYAQRYIAIYSLGTVFVQLSLGLNPFITAQGFSKAGMLTVLIGAVLNTLLDPLFIFVFHMDVQGAALATVISQAVSAAFVLRFLTGRQTILHLKRRLLRLNWKLLAPCVALGLAPFIMQSTESLVSVCFNTSLRAAGGTLAVGTMTICSTLMQFALLPLQGLSQGAQPIISFNYGAKRPERVKAAFRILLISCLAFSAVLGLTCIFAPQIFVYLLTPDAALREYAIPCVRLYMAGVTIFGAQIACQQTFVALGNAKCSLFLACLRKLILLIPLVYLLPLFIPDTVFAIFLAEPIADVLAVLCTVTLFMHVFRKTMRGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7II78</accession>
    <name>R7II78_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000199">
        <property type="protein sequence ID" value="CDE51176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51176">
        <property type="protein sequence ID" value="CDE51176"/>
        <property type="gene ID" value="BN770_00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436654" description="TGc domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="144"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="357" mass="39824" checksum="10108DA1FFDE5BF4" modified="2013-07-24" version="1">MQKIRFLPLLCVVLMLFTAPTLLAQQEPDTPYPAESMLSVRMMPPGERSLRNFLYPKLMAQEASIQLPAGTSYNLLVQTLDNMRNDYPELFHIDSYRVHYQRNQPDVAQSISPRYLCSAEEASALRKQLLETAQSWVDENPDPLALYERLVLNATYSPDSMWQHTAVGALLYGEATCAGYAQAISLLYRLAGIPCATIIGEASDTSGETGLHAWNVTNFGFLDATWGAAFDGHVFHSNYAMGEADMSIDHTPNRGYTFPDLSGVPNYYQAHGLYVSTEQELLTQLMRLVDGEAVEIQLSPDLYARYTAAMKDKPSDIVTFCAEAAGVEIPFYDPCRILSDKAHRVLLLIPHPELAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7II81</accession>
    <name>R7II81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000211">
        <property type="protein sequence ID" value="CDE51315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51315">
        <property type="protein sequence ID" value="CDE51315"/>
        <property type="gene ID" value="BN770_00377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="310"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="466" mass="53162" checksum="9B485E9A40709C51" modified="2013-07-24" version="1">MFIGRERELASLNRLYNSGKFEFVVLYGRRRVGKTALINHFIDGKPAIYFMGVESNAKQNLENFSKSIMEYASGYEGDMSFLSFQAALEMVFRLSEKERLILAIDEYPYVARASKSLASTLQLLIDKYKDHSKLMLILCGSSMSYMEDHVLAYKAPLYGRRTAQIKLLPFNFAETCGYFKNFSAEDKALAYGIMGGTPQYLLQMSDKLSIEENIKNTFLDATSSIYEEPINLLKQEVREPAIYTAIITAIATGSSRMSEISGKVGEDTNVCSTYLKNLITLGIVQKELPYGEKASKKAIYFIDDNMFRFWYRFVPENASLISRGAADLVYQRIEPYLSDYMGKVFEEICKQYLWKLLLSGKSPVEFTSLGRWWGNDPVHKRQAEIDIMGEQNKNTALFAECKWTNEKVDLGVLETLIERSNLFAYQKKHFFLFSKSGFTKGCIEKAKQLGNATLKTYADMIHDKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIB5</accession>
    <name>R7IIB5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000215">
        <property type="protein sequence ID" value="CDE51355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51355">
        <property type="protein sequence ID" value="CDE51355"/>
        <property type="gene ID" value="BN770_00395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1748" mass="198327" checksum="934EA10AA3BA79F6" modified="2013-07-24" version="1">MQNGANSVHKLLRTELEDYIKSQYFGKSPLLLSALSNHIDDEGLLYQKPFIESSPAYVTVPNGINTASIEPWMKEYFLQLAQAGIGVFPSPFAHQISALEAATKGENLFVSTGTGSGKTECFMWPLLAKMATEARNSKESWAKRGIRTIIMYPMNALVSDQVSRLRRMIGDPDKKFIKIFRSTCGDSVRRPQFGMYTGRTPYPGAQPSTEQDRKLEKTLARMSFPQSDSEKEFFNQLLKEGKIPAKADMNQFLQGLHESRHIPNDEDAELITRFEMQQFCPDILITNYSMLEYMLLRPRERKIWDDTREWLASCKENKLLFVIDEAHMYRGSSGGEVALLIRRLFHKLGISRDRVQFILTTASMPNKNQQDYDSVMKFANELTASDTETQFRYLTGEREVIDGQLKYGIPSELLLNADPGEFEDKDELKLSALLSFWRQLDGFDRTLNSLEAVCNWMYGNLVYYRPFHELIKYCRGNAVSLGELATGIFPDLDQENALKAVSVLLAIAPLAKNAKGSVLFPARMHMLFKGISGVYACANADCNCSHTEGGLTLGEIYLSDGNLICPHCGSVVYELYNDRRCGALFFKGYVLEDDAELHGNVYLWRYPGQLMDHRMKEVHLFIPTEDFELPVKQGKNAIKPCYLDVKSGFINFTDDSSAGKPWVRKLYYCNYSAKGRPQIITFPTCPHCRHQLSTSQLTSFSTRGNQSFFNLIKSQFQLQPAVPGKNEDPDRFPNEGRKVLLFSDSRQRAAKLARDMSDASDISAARQLFAIAIKTMEEQTVEQPMNSLYDFFCLAAGQHHVQMFHSDERIKFAEDCTSALNNYSRCVKRGREYTPRFTIANAPVQMQEYLLRLFAGGYNTLYDSATSWIEPTDQALFDAVDALDENHIKVTEKEFIDVFNAWMLSICDMYTALGHTISDTVRLKVRPNYGGYGLEKNWEFSKVIREIMGWSDGNEAEMAWKRVLKEAFLDAAQPDNGKLYVDLSRIKTRFDTMHAWYKCEQCSELTPFVLKHKCPSCGSTRIHKMEPEEYEALSFWRKPVEDAIQGEPIHVIDTEEHTAQLSHKDQRDDLWSKTEQYELRFQDLIQEGETPVDILSSTTTMEVGIDIGSLVAVGLRNIPPMRENYQQRAGRAGRRGSSLSTIVTFCEDGPHDTLYFNDPVPMFRGDPRKPWIDIRSEKLIQRHLAMVILQGFLAKQNMSLDAIPAAAFLQDYLDDFKNYLSSYNPDSDKLLVPIGAAFHYSTFEKELKEAFETLKEKCQAHPELFGVDEGAKEGEAKVLLDALYEEGIIPTYSFPKNVVGTYIPDMYGKILYEVDRGLDVAIGEYAPGRAIVVDKQTYQIGGFYYPGSERRHGQALTPARAYTEDPNYVKQVISCAECGWFGLMEEKTKHCPFCGNKDLRISREMMRPWGFAPRNAEAIPDVQLSEEYTAVQQPLYSTLPDAEEMKLAPGCKNIRIASRTNQRIIMLNKGSDDKGFMVCKDCGASMPGDNISVLNDINRPYKSKFARNRCRHGNSFNVNLGYDFITDMLVLEFTIDDKIIDARRYDNPWLSRAAQSLAEALRLVASKKLDVEFTELVTGYRLRKGAEASYVDIYLYDSLSSGAGYAVSVADVIDELLSDMKELLSSCDCGSACSKCLKHYRNQYVHGMLDRFAALQLLEWGIEGIKASPINPEKQISMIKPLTSILKQSGCEIFTDSEITAIGHRSKKKIVIYPAMWVEPHASNTVFVSDAYIKYAKPYAVQRILDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIF8</accession>
    <name>R7IIF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase and inactivated derivatives IS30 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000218">
        <property type="protein sequence ID" value="CDE51410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51410">
        <property type="protein sequence ID" value="CDE51410"/>
        <property type="gene ID" value="BN770_00421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="155"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="36223" checksum="69A4814D0DC8576E" modified="2013-07-24" version="1">MSYHQFTSDERKCLWELHRKNLSIRKIADALGRAPSSVSRELRRNRSEKGTWHPFPAHKKAKARRRHLRNSSLQTDLELRAYVIDGLNHFWTPEEIAGRWSLAHPDRPVSFATIYRHIKRKLLPGIEPKTHLRRRGKRKVNRNANFNTIHPDRIIPDWPDEIKNRLRIGDWEGDSIVGAKGKGAAVTLVDRCSGFITGHLVATRSAAETRQAILDALEGLPVCSLSLDNGSEFAEFRQLEEALEAPIFFAEPHKPWQRGCNENGNGLLRFFFPKGCDFLAVSPEYFAAVIDLLNHRPRKRLGWRTPFEVFFGVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIG4</accession>
    <name>R7IIG4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51231">
        <property type="protein sequence ID" value="CDE51231"/>
        <property type="gene ID" value="BN770_00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="27103" checksum="414BAD2070F8DE7F" modified="2013-07-24" version="1">MRLAIVEDDDKVRQQLQTYVLQYFQGRENDVEIRLFADGDEILEDYAADYDLIFLDIQMKRLDGLATAERIRERDEDVYLVFITNLANYAIRGYAVHALDFILKPVNFLMLRQVLMSVERLLDQKPKRYITLPTDTGLTRLDVSQITYVETDGHAVSIYTEKGAYRLRQSMRGMEELLGKYGFFRCNSCYLVNLRHVERVENGGAIVGGQALTISRPRHKAFMEALTKYLGGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIJ2</accession>
    <name>R7IIJ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotran_1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000221">
        <property type="protein sequence ID" value="CDE51450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51450">
        <property type="protein sequence ID" value="CDE51450"/>
        <property type="gene ID" value="BN770_00448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="118"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="327" mass="35729" checksum="CBAFB4616EF8A1AB" modified="2013-07-24" version="1">MRHGGNVWEGQPADWLDFSANLRPEGTPAWVMDTMRAALSQACYYPDRAMRAARAGLALYLGVDESCVLPTAGGAAAIDLTLGVRRGAVHVQPPTFGEYAERAKAHGRRVAANQAIQADDTVVICNPNNPTGTLLSPNDVLRMHRDVRNSGGELIVDEAFIDYCPDATIRHHVQDGLTVVGSLTKILCIPGVRLGYICAAPEQIARLQERAVTWSLNVLASAIAAELPRHQAEIAADAQANQARAERFARCLQEMGVRVTAGRVPFLLADFGHDMTKTVQHLRGQHILVRTCDSFGLPANYLRLAVKTDAENDLLMKVLYRENFDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIP5</accession>
    <name>R7IIP5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000199">
        <property type="protein sequence ID" value="CDE51173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51173">
        <property type="protein sequence ID" value="CDE51173"/>
        <property type="gene ID" value="BN770_00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="190" mass="21315" checksum="B107B9601727A2AA" modified="2013-07-24" version="1">MVAADLEGYGFDAGFVAVQQIQQLDGEAHLLAVAGIHAVEHGSPVLRFRSARARVEGQHRVIVVIVAAHEGFQLQRVGMLFERRQLIHRFGDGIFVLLFFRHFEHDLDIIGGRKQLFVVFEFAFEVGNLLVDLRGVIRVIPEFGLIHFLGQLIQLFADMVNMEGIARGEQGFTNLCQFAAILGNINERHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIS4</accession>
    <name>R7IIS4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0597 protein Desti_3490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000226">
        <property type="protein sequence ID" value="CDE51535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51535">
        <property type="protein sequence ID" value="CDE51535"/>
        <property type="gene ID" value="BN770_00484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021144">
        <property type="entry name" value="UPF0597"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30501">
        <property type="entry name" value="PTHR30501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006054">
        <property type="entry name" value="UCP006054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="1">
        <location>
            <begin position="85"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="420" mass="43164" checksum="87B5FCF87E7DBBAB" modified="2013-07-24" version="1">MDETQCLRMIRASLAPSTGCTEPAAIALNAATARKAAQGTVTQVTARLDAYLFKNAMGVGIPGADERGVDLCVALGITAGDADAGMNALHTVTAEQLAAAKALRGCVKVEIVDGVSGLYIETILRTDCDAVRVVTVGAHDHIALVEHAPFTEAPTEQESVEEGGAHCGSLAEFIAFADTVALDKLAFLRDALTMNRTIYDRAMSDELAHCVLPKITLDDPSLCASAKRMAGAASYARMHGVPLPVMTATGSGNQGITLFLTVDAAARYFSIPEEKELRAIALAALANVYIKSFIGPLSSVCACGVASGLSASLGVVYLLGGGEGEMVQAARNILGSVSGMICDGAKEGCASKVALSAGLAVEAACLALEGGGIHAQDGILDDSFDRLIAHLGELVCVGMGSTNSTIVHIMKDEKGYAASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIY2</accession>
    <name>R7IIY2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpA</name>
        <name evidence="15" type="ORF">BN770_00436</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51436">
        <property type="protein sequence ID" value="CDE51436"/>
        <property type="gene ID" value="BN770_00436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="14">
        <location>
            <begin position="106"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="12">
        <location>
            <begin position="230"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="13">
        <location>
            <begin position="452"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="250"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="11">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE51436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="588" mass="64674" checksum="CBDD3DFF8DE5DF8F" modified="2013-07-24" version="1">MTDTKQSRLTATLLCVTPPDEHQEQGIRTFLQKKYGEDVALTIQQDASLKSGFQLHVGSEVYDWSAKGRMEQFRQQVEQLVAKNTRKDIIPLLRSSIDEFRLLAKSSEVGTVKSIGDGIAVVEGLEHAAYGEILMFDNGIKGMVQDLRRNETGCILFDNADDISAGSKVARTGKTAGVPVGDAFLGRVVDALGRPIDGGDAIPADGYRPVEEPAPGIIDRQSVDTPMETGLLSIDAMFPIGRGQRELIIGDRQTGKTAIALDAMLNQKGKNVICVYVAIGQKVSSVAQLVENLRKRDAMDYCVVVSATAGEADTMQYIAPYAGCAMAEYYMHKGRDVLIVYDDLSKHAIAYRAMSLLLERAPGREAYPGDVFYLHSRLLERSAHLSDKLGGGSMTALPIVETQAGDVSAYIPTNIISITDGQIFLESDLFFAGQRPAVNVGLSVSRVGGAAQTKATKKATGSLRLDLAQYREMEVFTQFSSDLDDSTKEQLHYGQGLMRILRQKQYHPLSMHQQVIVLVCAMGHVLSKVAVKDVTDFRDALLDHFEQEHSDLCRSLEDEKVLTDDMKQEILRIAEEYLAANAERFRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ53</accession>
    <name>R7IJ53_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51516">
        <property type="protein sequence ID" value="CDE51516"/>
        <property type="gene ID" value="BN770_00471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="27097" checksum="1F4DF09BEB28CE97" modified="2013-07-24" version="1">MKEKPYILVVDDDPNIAKLEQLYLEKAGYEVKTVGRGDDAMTEFRKMPPDLMLLDVMMPGMDGWQVLKAVRKSSNIPIIMVTARDETFDKVLGLELGADDYITKPFDSKEMAARVKAVLRRTMGQTEEEEETADDTLSFPGLTVSLSRYEVFYEGKKLEMPPKELEVLYFLASHVNQLFTRGQLLDQVWGFQVEVESRTVDVHVKRLRDKLVGCEKYGWRIQTIWGRGYKFEVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJK2</accession>
    <name>R7IJK2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Mannonate dehydratase</fullName>
            <ecNumber evidence="5 6">4.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-mannonate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxuA</name>
        <name evidence="7" type="ORF">BN770_00721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="5 6"/>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51964">
        <property type="protein sequence ID" value="CDE51964"/>
        <property type="gene ID" value="BN770_00721"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00106">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="360" mass="41007" checksum="6EE6FA29386C8B44" modified="2013-07-24" version="1">MKMTFRWYGRESDPIPLKYVKQIPGMSGLMGLLDKPAGVDWPEEEVKALVEEVHAAGLELEVVESVNVHEDIKMGLPTRDEYIANYISTIRTLAKYGVKVIIYNFMPVFDWLRTDLARVIPEDGSNSLYFDEKDLGEMGPMEIVRRTAADSQGFTLPGWEPERLALLETTLRQYEKLTPDDLRANYKYFLDAVIPVCEEVGIRMACHPDDPAWPIFGLPRIAHSQEDFDKIIKLHDSPANTVCLCTGSLGCSPDNDIPSIIRHFGEMNRIGAMHVRNIKFLGYHHFREAAHLSEAGDLNMFDIMEAIYDTCPDTYIRPDHGRMIWDEKGRPGYGLYDRALGATYLNGLWEAICRMKGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJL5</accession>
    <name>R7IJL5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000246">
        <property type="protein sequence ID" value="CDE51800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51800">
        <property type="protein sequence ID" value="CDE51800"/>
        <property type="gene ID" value="BN770_00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="PTHR37417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="590" mass="67551" checksum="D8656FFA08C9B6D0" modified="2013-07-24" version="1">MYYSSGNYEAFAHPKKPEGVDHKSAYIVGAGLASLTAACYLVRDGQMKGEHIHIFEKDPVSGGACDGRKYDVGYMMRGGREMDNHFEVMWDLLRSIPSIETEGASVLDEYYWLNKEDPNFSLCRATEKQGQDAHTDGKFAISDKGAMEIMHLFFTPDEQLYDKRITDVFDDEVFSSNFWMYWRTMFAFENWHSALEMKLYIKRFIHHIGGLPDFKALRFTRYNQYESIILPMEKYLKEHGVQFHYATKVTDVRFDVTATRKQASSITVEHDGQTDVIDLTENDLLFITNGGCVESSTYGSQNTPAPFDPELKPGNGWDLWKKIAAQDASFGRPEKFCYDPEQSNWMSATVTTLDDKIPQYIQKICKRDPFSGHTVTGGIVTVKDSSWLMSWTLNRQQQFRDQPKDQLCVWVYGLFSDKPGDYVKKPMRDCTGKEICMEWLYHMGVPESEIEELAEHSANTVPVMMPYITAFFMPRAAGDRPDVVPEGAVNFAFLGQFAEVPRDTIFTTEYSMRTAMVAVYTLLNVDRGVPEVWGSTYDIRDLLNATVQLRDGKKITDLDLPLMERLALKEVLKKISGTDIEKLLKEYHCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK22</accession>
    <name>R7IK22_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSP1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51975">
        <property type="protein sequence ID" value="CDE51975"/>
        <property type="gene ID" value="BN770_00727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="438" mass="48448" checksum="06BB537D4AD21C82" modified="2013-07-24" version="1">MVNVIGVRFENAGKLYFFTPGALWPTPGDFVIVETTRGIEFGEVVTEVREIDDTKLTAPLKQVVRIATEEDILHDKENKAAEKEAFTICQKKIADHKLDMKLVSVEYTFDNKTILFYFTANGRVDFRSLVKDLAGVFKTRIELRQIGVRDEAKMLGGLGPCGRPICCGTFLGDFQPVSIKMAKEQNLSLNPIKISGVCGRLMCCLKYEQDTYEEIRKSMPKEGKEVMTPDGVGVVCELKIITESVKVRIKKGDSFEIKEYPATDVQRLTPQNAPRPEAQRAEKPEQKQDTPEAAEIKECPACPERPPRAERPMRPEKPMKVEKQPEAPKPEKPAEAPKPAVSPWKMAVEQALRAAQNSADTADEVIEQPVQEAPVSEETIAMPEAAPAAACEAVETVVEEFAAGAETPLSASTEAVEEAVEDAMEMPLIPLDEDDDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK23</accession>
    <name>R7IK23_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_00562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8 9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51663">
        <property type="protein sequence ID" value="CDE51663"/>
        <property type="gene ID" value="BN770_00562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012052">
        <property type="entry name" value="Spore_0_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002937">
        <property type="entry name" value="Res_reg_Spo0A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02875">
        <property type="entry name" value="spore_0_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 8" id="KW-0749">Sporulation</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28568" checksum="8E06F1F720D0CC0A" modified="2013-07-24" version="1">MSDMRIMLVDDNGDLRRGMRDYLVRQEGMKVVAECPSGAEALEALGKVRVDVMVLDLIMPQMDGFALMEEVRRQQLANPPQIIVVSALGRDDFIMRAVQLGARFYMVKPFDMASLAARIRESCGQGVVPLGTALNASARSLSIDEKLASLFLTIGIPAHIKGYQFLRTAVKMVVDNPDMINRITKELYPSIGKCYNTSASKVERAIRHAIEVAWSRGRIDTLNKAFGCRVATKEDKPTNGEFIAMLADKLSLEQRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK40</accession>
    <name>R7IK40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51816">
        <property type="protein sequence ID" value="CDE51816"/>
        <property type="gene ID" value="BN770_00626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="179" mass="20132" checksum="3D91029D49AA7BBD" modified="2013-07-24" version="1">MDIGEKLRLLRIRRGLTQEDMADRCELSKGFISQVERNLASPSIATLTDMLECLGSSLSQFFSEDKDEKTVFTPQDMFVKEDEQLCGSITWLVPDAQKNTMEPILVDLGEDGRTYELLPHQGEEFGYVLSGSIFLVDGETKTRVRAGSSFCLHPHETHYLMNAGKSHAKVLWISTPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKS8</accession>
    <name>R7IKS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein radA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51913">
        <property type="protein sequence ID" value="CDE51913"/>
        <property type="gene ID" value="BN770_00693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="1">
        <location>
            <begin position="74"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="183" mass="19388" checksum="6A31CC70A5C1671A" modified="2013-07-24" version="1">MQIVPNPSEQLLSHRAKGASGSVVFCGLEGSRPLLCDVQALASTSYFGTPRRTVGGADTGRVALLLAVLEKRANQKTYNQDVYINVAGGLELSEPAADLALCMAVVSSLKDAAIGAEVAVMGEVGLAGEVRAIPQCDRRISECQRLGFTTILLPKENMRRLKAPEGMKLVGVDTVMQAISVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKW8</accession>
    <name>R7IKW8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51232">
        <property type="protein sequence ID" value="CDE51232"/>
        <property type="gene ID" value="BN770_00337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="3">
        <location>
            <begin position="332"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="442" mass="49906" checksum="02716A04E9CF94D8" modified="2013-07-24" version="1">MVAFLEVGFFPRIHTAIAEWLACMLFILPQKKRFGESSWQQIGCCIGFLALLLGLNLLNQQQSGLTWMLLMAACMGTMLAMIVCCCKLKLMKAGYIWAHAFITAEFAASLEWQINYYLLMADSVDSRGTWLVMAGTYIIVFSAIYLLNQKHHILRSGTSVTRQELISGSAIALAAFCLSNFNFAFTNNVFTETLGTGIIYSRTLVDFGGVVMLFAYDMARSELYLSHELEAMENLLNRQYEQYRQFDANNKAMHQIYHDLKHQIDFIRNEKSASKRESYLAEMEKVVTLRDAEMNTGNAILDTVLTSKSLRCAEEGIVMTCFADAHDMGFIDMMDICSIFGNAIDNAIECVEKIADKNMRLIKLTVRTQNRFLLIRVENCTDKAIDLNGGQPATTKENKESHGYGIKSIRKAAEKYGGCMTLEQQDGWFIMTVLIPLAEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL36</accession>
    <name>R7IL36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000212">
        <property type="protein sequence ID" value="CDE51322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51322">
        <property type="protein sequence ID" value="CDE51322"/>
        <property type="gene ID" value="BN770_00384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436758" evidence="1">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="242" mass="27393" checksum="0019849ACBFCAB54" modified="2013-07-24" version="1">MKRAFLLLVLLCLLPIHALAQFITVPDEIYEALLADEVISSYASTKEELLPLITTLEGCDENNQAECAVIVTPPDGNPELLMLGKIDGHWQITTRSSSVLLNIDIEPFLYEERYAEIQLYYSSEEDERNGVPHAVLTFQREWDDKAGLHWYLTLLTFTDANGWWVHIEAPLRSIYVDVATNYNGGISQRVFYRESTDITCFNLDTILNDVLTEAAKTNATFLDISIPDWLVAYPASALQNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILD8</accession>
    <name>R7ILD8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51442">
        <property type="protein sequence ID" value="CDE51442"/>
        <property type="gene ID" value="BN770_00442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="295"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="436" mass="48693" checksum="98939F92F1F758F8" modified="2013-07-24" version="1">MNIILLSGGSGKRLWPLSNDIRSKQFIKIFKKEDGAYESMLQRVYSQIKQVDTDATVTIATSKTQVSAIHNQLGEHVGVSIEPCRRDTFPAIALATAYLVDVLHIDPSESVVVCPVDPYVEDAYFEALKELSAQADKGEANLILMGIEPTYPSEKYGYIIPQNGEHISSVDTFKEKPTADVAAEYIARGALWNGGVFAYKLSYMINKAHELIDFIDYQDLFSKYAAIKKISFDYAVAEHEKQIQVVRFAGMWKDLGTWNTLTEAMEETIIGKGELNDKCSGVHIINELDVPVLAMGLHDVVISASAEGILVSDKEQSSYIKPFVDKYEQQIMFAEKSWGSFRVVDVEMNSLTIKVTLNPGHNMNYHSHQYRDEVWVVISGAGRTIVEGVERPVKTGDVITMTAGQRHTVIADTELKMIEVQLGKDISVHDKKKFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILP3</accession>
    <name>R7ILP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000228">
        <property type="protein sequence ID" value="CDE51547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51547">
        <property type="protein sequence ID" value="CDE51547"/>
        <property type="gene ID" value="BN770_00490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="449" mass="50621" checksum="22B6DFC46FE49694" modified="2013-07-24" version="1">MPNPYLPLWEYIPDGEPRVFGNRVYVYGSHDRVGHDQFCDYVLKCWSAPVDDLGHWTDHGVIFRTRDTFDHPADTDWTKENNELYAPDVVEKDGKYYLFAYIIGAKGCVAVSDRPEGPFTLLGRYKYTIPDSVCVNGWFIDPGVLVDDDGQVYIACGFERSFIAKIDPQDMTHVLDGTYLEHIIPCEVTENGGFTDPDSRFYEAASLRKIGDTYYFIYSPKRGSRLAYATSDKPMGPYTYRGYIVDNGVDYPAGNNHGSICRIGNQWYIFYHRMTNGSVMSRRACVEKIEILPDGTIPPVEMTSLGFSDALNPYEETPAELACVLKGGALIAERTPFERVITNIQDGCVMGYKYFDFGADYGSKTMQLFADVMGFGCACDVHVRLDAEDGEEIGCFHVGRGAECIKTRVKAVTGRHALYFAVTTHYSGWTGDFFAGRCLMEFKKFVFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IM49</accession>
    <name>R7IM49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51697">
        <property type="protein sequence ID" value="CDE51697"/>
        <property type="gene ID" value="BN770_00573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="202" mass="22336" checksum="0D9FEF6061C19233" modified="2013-07-24" version="1">MAFFENTRKPTGFGGRLMVVMMNIGHRALADWGLRFLPLAENADVLDCGCGGGANLRLMLKKCPTGKVCGIDYSPVSVEKSRKLNQTAVSAGRCEVLQASVQALPFDDAQFDVATAFETVYFWGDLPACFREVGRVLKPGGTFFLCNESDGDHAQDEKWTEKIPGMTIYKDTQLKTMLEQVGFRQVETHKNGKGWLCVTARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMT5</accession>
    <name>R7IMT5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51942">
        <property type="protein sequence ID" value="CDE51942"/>
        <property type="gene ID" value="BN770_00709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="70" mass="7519" checksum="C2F031EF4B6A5DC9" modified="2013-07-24" version="1">MMEKTMQINGMMCNHCKMTVEKALKAVSGVENVEVDLAAKCAKITLNADVADDVLMDAVAKKGFTPVKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3W6</accession>
    <name>R7I3W6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000003">
        <property type="protein sequence ID" value="CDE46171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46171">
        <property type="protein sequence ID" value="CDE46171"/>
        <property type="gene ID" value="BN770_00764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="383" mass="43868" checksum="C2EB50A9B2A6040A" modified="2013-07-24" version="1">MYSKDDINKLYREIAASIDISDDMFTAAVDEYESLGKWIDENTPQYQISIYPQGSFGLGTVVKPITDEDDYDLDIVCQFKEQYGLTAKQLKVDVVKPLLLGYKKTSRDIENKRRCWHVEYAEIPNFHMDVIPAYANAKLKRINITDHDEDHDTYDYIGSNPSGYITWFFERCARQQKRLLDSYMKEHGLVVASADAEEIKRRKIKTPLQRVVQLLKRHRDIMFADDDSGNKPISIIITTIAATLYQEEDNIVDAMTNILLEAPKWINRNKKNGLYYIENPSYPGENFADKWNTHPERATAFFNWVKQATADLTGNQLYQMSRIDMGENVKMCFGEKTGKTVFSKAAEECRAGVENGSLKVDRSSGNLSTKGTVSVPTTRHYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I453</accession>
    <name>R7I453_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46669">
        <property type="protein sequence ID" value="CDE46669"/>
        <property type="gene ID" value="BN770_00981"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="270" mass="30665" checksum="745C7403B8592BB6" modified="2013-07-24" version="1">MEHRRMDYHLHTNHSMDGRQTMPELCETMLARGVQEIALTEHIEPGHPEEEMDVPPVWADWFAEIAHCRAAYPALIIRSGIEIGDNPLCRAETKALLDTLPLDFRLLSLHLVNGVDCYDSEKYFAGKTRAQAYREYAEAKAESILDWEDFDSVAHIGYVAKFSIYTGKERALVYEDAPDAFDAIFRHVIALGKCIEVNTSGYATTGDTFAHSSLIRRYIELGGENFTFGSDSHDTVRDYADVERAKEMVRALGGKYQVSFEGRKAIYWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I467</accession>
    <name>R7I467_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L1 and related esterases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46241">
        <property type="protein sequence ID" value="CDE46241"/>
        <property type="gene ID" value="BN770_00797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="250" mass="28041" checksum="0F33D7871762A060" modified="2013-07-24" version="1">MTTIFWAGDSTVKQNSIATYPQTGIGQVFDRYVKRYQVQIENYAENGRSTKQFIDEGRLATIYDRIHAGDFLFVQFGHNDEKASDPARYTDPETDFPANLERFVNVAWNKGATPVFITPLTRYDRNAPGAQFHHDRWAESMRRTAEKLHVALIDLTAMSEKLVDEQGEAAQTTYYMNLPAGIYPHFPLGQHDNTHLQPAGALAFGGLIAKSLHDLGGEYAALLCDEYDQWEKEAAQFGQIATSAAEDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I489</accession>
    <name>R7I489_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46266">
        <property type="protein sequence ID" value="CDE46266"/>
        <property type="gene ID" value="BN770_00815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013418">
        <property type="entry name" value="CRISPR-assoc_prot_Csd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02589">
        <property type="entry name" value="cas_Csd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01595">
        <property type="entry name" value="cas_CT1132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="300" mass="33830" checksum="FBF3104205363744" modified="2013-07-24" version="1">MSDVIRNRYDFVVLFDVQNGNPNGDPDAGNMPRTDPETGLGLVTDVCLKRKIRDYVATVKEGDPHYGIYIQDGVPLNRCDREGLEACGYGDIKEDDLKKKLKSNDPEIDRKLRDYMCSHYYDIRTFGAVMTTFVKASLNCGQVRGPVQLGFARSVDPIVPQEITITRVAITTEKDAEKKGTEMGRKYIVPYGLYRVEGFVSANLARKTTGFSEEDLALLWDAILNMFENDHSAARGMMAVRKLIIFRHEKELGNAPAWKLFERVRVARKADVTVPRSFTDYEWTVDDANLPDGVTCEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4H9</accession>
    <name>R7I4H9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000003">
        <property type="protein sequence ID" value="CDE46168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46168">
        <property type="protein sequence ID" value="CDE46168"/>
        <property type="gene ID" value="BN770_00763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="459"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="890" mass="102724" checksum="7A1F2600FA89CF9D" modified="2013-07-24" version="1">MFNIGDFVFDTIAGANVQIMERIELWGYTSYKVFNPANGSVYKATGEQLKRGGGEAQLDENYLRYVTLLSKIRNETSAGILSAFSSGVIPLPHQLHVLERALETRNIRYILADEVGLGKTIEAGMIIKELKARGLITRILVVCPTGLVSQWSVEMQEKFHEKFQVILPSDFDTIRRLTDNDDVYGQFDQVISPMDSIKPVEKHAGWSDKRVEKYNQERIEAIINSGWDLIIIDEAHRVAGSSSYVARYKLGYLLSQASPYLLLLTATPHNGKTEPFLRLVRLLDEQAFPNYKSIVKEQVAPYLIRSEKREAIDNNGNLLFKKRYTHLVELHWDERHSLQRQLYELVSSYVSKIYDKARWNRKKNMCLIFLMIIMQRMVTSSTAAVRQSLEHRLRVLLEEETRVNTMSESDWDERDIEDGDADAMEAMSLDRSAEIEELKMIISVAKQAEFQHHDVKVDALFDTIDELQSEDPAQKIILFTEFVGTQVYLKELLESRGYSVSVLNGSMDIEERNNALNEFKMSTGIFISTDAGGEGLNLQFANIIINYDLPWNPMKIEQRCGRADRIGQQRDVHIYNMIIGDTVESRVREVLEEKLSVIMKELGIDKYSDVLDNEVAECDFTDAYMSSIGHASRIEQNIYSVEMEMRQQVGNALKYKDILHEEKDLTQLVGKESNFDVDTALRQMLVYYESWKGNDPTIIDRISINDEMITKHLCGSIVQDHTKQLMSVVIRNFPNEAGYFMLWELSVSEDTQDKRIIPIFVNESYVLRPMAGSKIMEVFLDGSSRLDCRMVHNLSEENYQRLQEICMNFAYNTFVELKEKQTKRSTEQYEKYNYALSLRREAAGHIGIENIRRSRIAKLEREEREIEEEHKRSGTVLPDFRLMILIQLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4R2</accession>
    <name>R7I4R2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46854">
        <property type="protein sequence ID" value="CDE46854"/>
        <property type="gene ID" value="BN770_01053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="683" mass="76661" checksum="F45827C06F3DF285" modified="2013-07-24" version="1">MKKPLLYPKLAWQGIRKNAETYLPYLLMGILMVGVSYIMNYLTRPALMSALSMGGTTLMVLQMGKIVISVFSVIFLYYCNSFLIRRRMKEFGLYNILGMGKGNIARVMLWETLLTALLVFAGGLLLGLSLSRLVEMALINLLHADYTVPMELFYPDGVTWVLLLFGGIYVLILLANLLRMRLSNPVALLKSENTGEKPPKANWFFGLIGLLILLSAYYVAAVSQSPLEALIFFFIAVLMVIVATYLLLVSGSVTLCRMLRRNKRYYYQTRHFISVSAMAYRMKRNGAGMATICILCTMVLVILTSTVCLYGGTDSMVDAICPQDINLTIGLEARDGEENWKRLDAMQQMALDVTEEMGLTPENITSQRALVATGKVQNGDYGIITDADSLKANVLELTVYPLSVYEQATGETVTLADRELLYASFKTNETFSSMSFYGSAPYRMIRAEKELPKRLLSADYRSAWGCLVVFTNDAEAFRSEITALVGKNSGKAMMMDRLALHFDLDSEADTDTQEKLVKTLRSRSWEAMKSTGKDFYGMSSLNVDTRALCRRDYLSFFGGLFFLGMVLGPLFSIAAVLIMYYKQICEGYEDAERFAVMRKVGLTDAEIRRSVNSQVLTVFFAPLLMAGLHMLFAMPMIRLILGAFGLHNDSLFYGIGIGCYVVFAVIYALMYLLTSRRYYRIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4V5</accession>
    <name>R7I4V5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46526">
        <property type="protein sequence ID" value="CDE46526"/>
        <property type="gene ID" value="BN770_00920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013663">
        <property type="entry name" value="Helicase_SWF/SNF/SWI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08455">
        <property type="entry name" value="SNF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="613"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="890"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118461" checksum="8386AD6526E81592" modified="2013-07-24" version="1">MTQVPYTLRVLAGETETRYGERLYHSGAVHIVEKSAKRLSCKVADGEMYDVVFTDDGESRCSCPIYEEAGACRHVVAAMIKCQDEGAMGDMVRRKAEAAGPKLMAAMDRALPEEGTIHMEVRLTLEPVREQITPRIRICLLIGEERLYVVKSIPQMIDAIDTQTPVEYGKGFVFHPEWMRFGTVQERILKILRALCLAQKEAGALLRGAEQRDLALPEPFAEEILRELMNTPFRLKVGEKTVAVKPVRARKIPLQFRVSSDLHGLTVVAMFPKEFRPLLPSCSFALVGENVVAVEEQQRGVLRVLYQEQLGGQCSFDYPVREAARVMGELVPFLKLTGLVEISDELRRQLIQLPLVARVYLDRSANGRDVVARAQFRYGDRTIDPFDETPLPENLPRGEKLLLRDAAAERKVLDALGAAGFIVSKGHVYLTGQEAIFNFVSEGLQHLQELAEVYLSNDFKRMTPRKPKFAGKMRLNGSALELKFTQDDEPAQEILAIMEALARRRRYFRLKDGSFLDLSAMDEWLPLADSIFEAAQAEGAESVAMGDDTIRLQAYRACYLQSLLESLGLPIEVDEKTQETVRLLTDPGKVQDVKLPDGLSLRPYQERGFQWLLALDRLHMGGVLADDMGLGKTVQVIALLMATRQEGQVSLVVAPTTLTYNWLSELGRFAPDLSVMVLGGSAAQRASQIRHVKEAHDVDVLITSYPLIRQDIEQLTTIEFRFAILDEAQHIKNAGSKGAQAVRQLQAQTRFALTGTPLENGVGELWSIFNFVLPGYLLSYSAFLRRYQDGTDAEDLRRRISPFLMRRLKKEVLTELPDKIESVFTAQMSPEQAKVYEATMMRLRQRVDSIVKEKGFERGRTEVLAAITQLREICCHPSLVLDDYTGTSGKLDMLLDMLPEAIAKGRRVLLFSAFTSMLKILRRELDDAGYETMYLDGDTPAQRRVEMAEQFNAGQGQIFLISLKAGGTGLNLTGADMVIHYDPWWNPAAEDQATDRAYRIGQTRKVEVIRLVTHASIEEQVVALGQRKKALFDQLIKPGESMVGGLSPQEIMSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5D2</accession>
    <name>R7I5D2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46468">
        <property type="protein sequence ID" value="CDE46468"/>
        <property type="gene ID" value="BN770_00880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435427" evidence="2">
        <location>
            <begin position="25"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="3">
        <location>
            <begin position="163"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="390" mass="44254" checksum="4FBB95CDEC7E42E7" modified="2013-07-24" version="1">MKKSSGKKRVSSLTFLIATTAVLAAVAVLCLFGSNLLYAMRVRNVNEQRAEVEKRNTERYEAYRQEVQELQDRLTANNNISADWPQPDTQEGISIVDLTNYPLDNPGTVTVSRQDVMLGGLLLVNEWHSRPSDFDESSLVSIMTYARSMGVTKSIWRNSDQRLFPVAANALLDALNAAKEAGLEGYVVREAYRSISDQQTLWDAEYNRLKGRHSAWTDDELIAATKKSINLPGTSEYNSGLAFTLYLYENGNDELNKMVFSESEQGKWMYENSWKYGLVFRFPLQDFPTKGTVSRAYKTGVNVEMNLFRFVGIPNATVMHHLDMCLEEYIEYLMAHPHIAVFEDGQLKYEIVRQQVGDDSSTFSVSISRKTSNYTMSLDNMGGLITIYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5K2</accession>
    <name>R7I5K2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46746">
        <property type="protein sequence ID" value="CDE46746"/>
        <property type="gene ID" value="BN770_00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08182">
        <property type="entry name" value="HEPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035873">
        <property type="entry name" value="PhpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="374" mass="40108" checksum="B47606CB0E78E086" modified="2013-07-24" version="1">MPSWLKEGRGSLCGANVSLLLREMGITKPLLVAGERTKNVFFARTGMRLPVFDAFHPNPDLQDCVAGAALYQEKECDGLISVGGGSAMDTAKGIKALLMTDIAHVRANQLPPEGKVSHLAIPGTAGTGAETTAVAVLYENGQKLSVDHPALLPDGVLLDGSLLDTLPEYHRKSCAMDALAQGIESWWAKKATPGSRIHAERAIRGVLDNLTAYLQGDRKAQDEMLHAAYESGVAILTTRTTAAHAMSYQITKKLGAAHGHACMLTLPHLWAHLAAQAEYQPMLTELSRLLGGEKPMDGAILLKGLLAVLELDKIPMPDDATLDMLAASVNPERLGNHPEALTTAQLRAIYVQAFTPMTDPERAEAIAAWEQYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5K7</accession>
    <name>R7I5K7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46751">
        <property type="protein sequence ID" value="CDE46751"/>
        <property type="gene ID" value="BN770_00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="63"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="283" mass="32139" checksum="084DE7FAD7C55A48" modified="2013-07-24" version="1">MFRKKKVVWLLLLPGLAGLMLFYVVPFFGGIYSSLMDGSFENQFVGLANYERTLQNSMFQLGLKNTWELSLLCAPVIWLLAFLLAAMLKTLKDRSTAFRNILLLPYLMPSSAMLLIWTLMFDYGGVINRMVTALGMERVLWLEGDALRVPIVLLYIWKNVGFSVVLFASALSAVHPSLYEYAALEGAGWWTQSFRITLPQIMPTAFLVFVLAWVNAFKIFKEVYFIGGAYPSNAIYTLQHFMNNKFARLEYQDVTTAAYIFAVGVMVLFALMYLSKAVRSPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7I672</accession>
    <name>R7I672_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cadmium-exporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47150">
        <property type="protein sequence ID" value="CDE47150"/>
        <property type="gene ID" value="BN770_00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="865"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="891"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="171"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="916" mass="99042" checksum="0D6C2D8E0D6CEB9C" modified="2013-07-24" version="1">MKKTWRIDIDCPNCAAKVERALQKLPGVVGASVNYVQKKITLEAADDRFEEVRKAAYAKMKEIEPDAEIFFDEAPAEAQGNIKQSWKLDIDCPNCAAKVERALQKLPGVVSVSLNYVQKKITLEAPADRFEEVRKAAYAKMKEIEPDAEIFFDEAPAEVQGNIKQSWKLDIDCPNCAAKVERALQKLPGVVSVSLNYVQKKITLEAPADRFEEVRKAAYAKMKEIEPDAEIFFDEAEQPSGTSCPCGGHHHEDDDDDEHEHHHHHDGKCGCGHEHHHHDDDDDDDDHEHREHSHEHGHEHGGANKGKKLMIRVATAVALLALGLVSKANLGETHWATIVVFIAAYLVAGYDVLWRAICNIRHGEVFDENFLMTVASVGAMCVAEYAEGVAVMVLYQIGEYFQDKAVDKSRESITKLMDIRPDYANLVDGNDSRRVSPEQVRVGDIILVKPGEKIPLDGVVIEGNSSLNTTALTGESLPRDVKEGDQVLSGCVNLSGVMKVKVTVGYGESTVAKILALVESSGDAKAKTERFITKFSRIYTPAVCFFALALAIIPSLFDGNWTKWIYTALTFLVISCPCALVISVPLTFFSGIGGASKKGILIKGATYLETLAGLDTVVFDKTGTLTKGTFSVTVAHPAKGVTRDELLDAAAHAEAFSDHPIAISIKEALGCAVDMNRVSDASEAAGHGVQAKVDGQQVYAGNARLMESIGVKAAEPAEIGTVVHVARGGQYLGALVISDVIKENSASAMEALKSAGVKRLVMLTGDRKEVAADIAKKVGLTDYRAELLPEDKVSALEGLLGDGHTVAFTGDGINDAPVLRRADIGIAMGGVGADAAIEAADIVLMDDDPAKIAQGVRHARRTMRIVHQNIIFALAVKLLVMVLGICGFANMWLAVFADVGVAMLAILNAMRAMKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6E2</accession>
    <name>R7I6E2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46793">
        <property type="protein sequence ID" value="CDE46793"/>
        <property type="gene ID" value="BN770_01021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="29"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="329" mass="37252" checksum="007691E5CC144DB8" modified="2013-07-24" version="1">MEQQGINPPFIVTDGLTKTYIRREKPEHGGITRLWRRETREVQALRDVSFRIGRGELVGLIGPNGAGKSTLVKLMTGILTPTSGSCTVNGHTPWAERKAHVRSLGAVFGQRMQLWWDVPIRDSFDLLRDIYSIDEGRYRHRLDELTTALDLGDIMQSPLRQLSLGQRMRAELCGSLLHEPELLFLDEPTIGLDAVSKLKLREFLRVENETRRTTILLTTHDMEDMRALCSRVMVLGHGQLLYDGTLTNLLHRYDTAHTLTVTYDGAADASKLPQGAVKDGDTWRITLQKDGDLSETMRQVMAAGKMHEMAIEEQNVDELIARMYREMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6U7</accession>
    <name>R7I6U7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000030">
        <property type="protein sequence ID" value="CDE46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46993">
        <property type="protein sequence ID" value="CDE46993"/>
        <property type="gene ID" value="BN770_01094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="665" mass="74040" checksum="190DCC05F343C5AE" modified="2013-07-24" version="1">MMDKNESALRNADSWYLADDAGNAVSSRSPLHTVLETIFGRDHHAISRWCLICAALLVLLLPIVRRQSASVMLCAFLLMVLLGTIGYLPLTLVLTGGIDLLTVKPLAFLLGGLAVLMSFASGAVLLRRLMAWLSVKDAKLALPPCSAGASGGLLAYLRKIRVTQKGTVAIVALVCVALCCWQLLPTEHIGGVNNGDFGRMMEQIDLYWAQPQLDDESTQFEWGVVENYSYREPFHPARLTSIDPTYSLIFPSMLVRFITLLTGGNYSTQVQAFILLALVMAALLLLVHDLYPLLGKLTLPAGLIVACMLLGENYLAWYNSLFGETMIPVGLMLTIACTVHLALMPRGSRKSWLWMILLAISVRFLCTAKAQMALALPAALVLLIVFTVYHHPQAKKPLIAFSLMGALLCGLVSYDTLGVYRKNQGVSEKQTIWQSMFYGALMIADDPDAAMEELGIPAEMKADIGKHAYYPNSEYVYPIESDELQEKFYDHVTTMTLVRYYLRHPKDMLTMMNRAAQESVTLSTSFMTYTGALYSDNRPMHRMNLWCNLRSIFAARAFWVYVLLYGTAGVFCLTLICRKKTQKQTKLLAMLFLCVMFVGVMQYPLSVIGNGFADNNKQMYTFMLCHDLLVVAAGVVLVRRLISARRTAENAFREEADHEPQEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I735</accession>
    <name>R7I735_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47460">
        <property type="protein sequence ID" value="CDE47460"/>
        <property type="gene ID" value="BN770_01261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="395" mass="44336" checksum="4A8C494E863FA7FB" modified="2013-07-24" version="1">MPLAQLPPMGWNSWNTFGWQINEKLIFEMADLMASQGYREAGYEYLVIDDCWSLRERGKDGRIVPDPEKFPNGMKAVADYVHSKGLKFGMYSCAGVRTCAGYPGSYDHEFVDAQTFADWGVDFLKYDFCNFPQSGNCKARYLTMSMALKATGREILFSACNWGMEEPGEWMRAIGAHMYRSTGDIMDNFVSFTDIVKSQLNKLCMSGNHCFNDMDMLTVGMEGKGNVGLGKVCSYEEYRLQFVLWCLCGVPLMMGADLRSLAPEYRALMLNPALLRINQDAECRPPYIVRRDSVCIPNPDDAQAPWAHPADTAFVLLRHLTDNEFALFYANLSDADAEVHCEMADMGLPVTGGVALDITDVFSGEHLGPQKDSFNPHIKAHDCRLFLCHLVKDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7A3</accession>
    <name>R7I7A3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000036">
        <property type="protein sequence ID" value="CDE47158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47158">
        <property type="protein sequence ID" value="CDE47158"/>
        <property type="gene ID" value="BN770_01155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="97" mass="11088" checksum="66D938EC7DB7AA2A" modified="2013-07-24" version="1">MLCEPVYCETNGDKGYLAREIAQRGFLVRRYSERMNKHVKIATYLRKWWGNVTILAGTDRAYVDQILDYSETAAHDDAPDSASCVMRILDKGSRLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7B8</accession>
    <name>R7I7B8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ORF">BN770_00857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000014">
        <property type="protein sequence ID" value="CDE46417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46417">
        <property type="protein sequence ID" value="CDE46417"/>
        <property type="gene ID" value="BN770_00857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="289" mass="31763" checksum="1AEB92F86D7BA0BB" modified="2013-07-24" version="1">MPTLYVVGTPIGNLQDMTPRAIDTLRRVALIAAEDTRVTKKLLTVFDIDTPLTACHQHNEDTKGAYLADKMLADNIDIALTTDAGTPCISDPGYALVKACVDRGIEVLAIPGCCASISALSVSGFDTREFAFYGFLPREKKDLREKLLQMARQVPIAAVHESPFRVVELVEVVCDTLPGCRISASCDLTKLHEKTIRGDAADVLRQLRENPKAEKGEYCLILDFHDVRLPEEKSPAADVSLEARLIDEMVRNGLTLRDAQSELVLDGEKKNAVKAAALRLKKLFEEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7F1</accession>
    <name>R7I7F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000046">
        <property type="protein sequence ID" value="CDE47416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47416">
        <property type="protein sequence ID" value="CDE47416"/>
        <property type="gene ID" value="BN770_00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448046" evidence="1">
        <location>
            <begin position="27"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="371" mass="42945" checksum="9F8ED50435CCEA8A" modified="2013-07-24" version="1">MTNRWKRLTALMLILLTLLNAGSALAAEEFWKWGDEFQQWEAWEGQVRVLSTQVYKDELYFVYGRQLLKCHDPESKPEEVMQLKKLLPEEEQPYYAEDNYYGHIVLTAYLFTDGDALYIFAQGMHKVFRIDFVDGEATPVLCAELDFDDVEGVNRESTDGSERVFKPYYSYGRIAKIGEKIYMRGIYGTSQNTKAGFFCFSLENGKGKLLGNVLATTQIVSWQENPEWASTLLIMRNDGHWEWKGDTSYYLDERAVLVYNPETFEPEQTVFAFANLGLENQKEYDLDLGVYHYNPSCTALAVDAESGRFFFLHDDIAWYTDGTTTARGFDRLPEEAYHAAYGFFWKGNYYYMTHGDTLYVCDMSRVPQSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7K9</accession>
    <name>R7I7K9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000040">
        <property type="protein sequence ID" value="CDE47243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47243">
        <property type="protein sequence ID" value="CDE47243"/>
        <property type="gene ID" value="BN770_01178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="165" mass="18372" checksum="4B457C8DE02F7D94" modified="2013-07-24" version="1">MREKLELRTKKSAVILTACAPVALSVLPVLAISLLLLPPSFTLMILGLMIAACSLTMAFYIPSYLGSYAFQPATNLHGARIVANLGRANTYEVSGVSAQDILVKQSRLEKRLRVCHIRVKGTAYYFRGVPEMEKVQAWVTANFPEKSKVEQRMESKGSKQKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7P6</accession>
    <name>R7I7P6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000055">
        <property type="protein sequence ID" value="CDE47645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47645">
        <property type="protein sequence ID" value="CDE47645"/>
        <property type="gene ID" value="BN770_01323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="128" mass="14410" checksum="95C591648678AAE1" modified="2013-07-24" version="1">MRSIVVSMQNMLLSEAVARTLAETGEFRVEQVLPGKTSDTFSLCRAMQADILLMEVSRLPAYTLENRLKLIACVRKVMPSCKFVLLCDENVDPEFAHRVMIVRQDRLIDAFLYASVTHAYLTAALDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7T7</accession>
    <name>R7I7T7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative stage V sporulation protein AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000057">
        <property type="protein sequence ID" value="CDE47680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47680">
        <property type="protein sequence ID" value="CDE47680"/>
        <property type="gene ID" value="BN770_00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014204">
        <property type="entry name" value="Spore_V_AE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005562">
        <property type="entry name" value="SpoVA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38450">
        <property type="entry name" value="PTHR38450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03862">
        <property type="entry name" value="SpoVAC_SpoVAEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02839">
        <property type="entry name" value="spore_V_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="122" mass="12482" checksum="27DA461D15AA20B1" modified="2013-07-24" version="1">MTIVWNLIKAFLVGGALCMIGEILLLKTKLTPARILVGYIVAGVFLSAIGVYAPLAQFAGAGASVPLTGFGHALVTGVKRAVQEIGFLGAFTGGLTSTAAGISAAVFFGVLMALIFQPRAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I816</accession>
    <name>R7I816_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48014">
        <property type="protein sequence ID" value="CDE48014"/>
        <property type="gene ID" value="BN770_01492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="36" mass="4337" checksum="9A64D3E3151FACAD" modified="2013-07-24" version="1">MLARKIEKQFRCFHEADDSFDQIFETYSPSTVRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I824</accession>
    <name>R7I824_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48024">
        <property type="protein sequence ID" value="CDE48024"/>
        <property type="gene ID" value="BN770_01500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33323" checksum="58864F6F6BB6D305" modified="2013-07-24" version="1">MLFYILKRVLLALLTIWIVITVTFFVMHSIPGGPFASEKAISAEAQAALEAKYGLDKPLGEQYVTYLRDVVTKLDFGPSLKQRGRQVIDIILDGMKTSAKLGLIAAFSAAIVGIVLGALAALRRNTVLDKIIMVITTAFVSMPSFIMGSFLLIVFSVKLGWVPANGATAEGLILPIITLALYPMSYITRLTRSSMLDVLGQDYIRTARAKGVSGKKIIFGHALKNSLIPVITYFGPMLAFIVTGSMVVEQIFAVPGIGRQFVSSITNRDYTMIMGTTIFLASLIVIMNLISDLLYKVVDPRIDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8C7</accession>
    <name>R7I8C7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47860">
        <property type="protein sequence ID" value="CDE47860"/>
        <property type="gene ID" value="BN770_01395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="226" mass="24597" checksum="61C546BAD7119C7D" modified="2013-07-24" version="1">MPKNNKSTAKSPFTPKPVVYTAWGLLAAALVAHFVPALEAVALILYAVGLIALCLPALTAPKKGTIAVPRVFLPMLAAAFLIVGCQIGMRPDESPLVWRSILLALILLIPLMISEKQAAADINRGRFATRVFIVVGVLWMSCAFWLIATNSVFDADVGMSHISTVSQTRATSRYCYMDVVWDGRTLDFPVSKEDSSAISAGDEVLVTEYDGFWGAPYYTWEIPQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8D1</accession>
    <name>R7I8D1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YabP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47865">
        <property type="protein sequence ID" value="CDE47865"/>
        <property type="gene ID" value="BN770_01400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022476">
        <property type="entry name" value="Spore_YabP/YqfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07873">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9060" checksum="5B94BD0E6A78457A" modified="2013-07-24" version="1">MEKEPFFPPEVTGGAFKVTLTGRGRAWVEQHQGLLGYTAEEALFRTKEGTLRISGANLRFLRYSSSDAIVTGQIDAISVLGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8M3</accession>
    <name>R7I8M3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000066">
        <property type="protein sequence ID" value="CDE47836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47836">
        <property type="protein sequence ID" value="CDE47836"/>
        <property type="gene ID" value="BN770_01385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="78" mass="8640" checksum="C2D41C6FA65A0274" modified="2013-07-24" version="1">MTSILIKDTTREERQQIVDDAIGNISASCDGCAEGIIEMYQAYIDGEMELREVNAAFNARYVSGEQGAARRSCFGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8P2</accession>
    <name>R7I8P2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47861">
        <property type="protein sequence ID" value="CDE47861"/>
        <property type="gene ID" value="BN770_01396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030949">
        <property type="entry name" value="ECF_S_folate_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04518">
        <property type="entry name" value="ECF_S_folT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="209" mass="22833" checksum="7AB2B7DE956864C5" modified="2013-07-24" version="1">MSQSVFHAHYWRDCARLTTQKLCVMGVLMALQIILSRITAINLGNWLRISFGFLPNAIAGYLLGPIGGTLVAWGSDALGTILTGQAINPGLSVAAALGGFFYGLMLHKRPVTIWRTMACLLVVSLVCHFLLNTYFLAMAGFTAVSDGADYPAFVRELVRPIYGEGATMPAWISVCNRFIKQVVVYPVNVAMLLLMLRGVQRMPNAVTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I907</accession>
    <name>R7I907_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inactive homologs of metal-dependent proteases putative molecular chaperones</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47986">
        <property type="protein sequence ID" value="CDE47986"/>
        <property type="gene ID" value="BN770_01473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="233" mass="24668" checksum="ECD40B13B04ED9F5" modified="2013-07-24" version="1">MKLLAVDTSGPVCGVAILTEDGIRHECAVMNHKTHSVNLLPMIDNAFQSTGLTIQDMDRLAVVVGPGSFTGVRLGVSTVKGLAHGAGKPCVAVNALEAMAAGISGFSGVVCPIQDARAGQVYGAAFSAGENRPNRLMADTPMKVEDYVAEISRFGDRFLFLGDGMSVHRQKLQTLLGDAATFAQPHQAFLRPASVAYLASLETETVDYLTLMPLYLRAPNAALNKKLTEGLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I934</accession>
    <name>R7I934_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48120">
        <property type="protein sequence ID" value="CDE48120"/>
        <property type="gene ID" value="BN770_01540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="532" mass="58869" checksum="797526AEB533FF33" modified="2013-07-24" version="1">MSNSRPPYDGAGDAGQNPQQPGFSQGNYPPAQGYAPNGGYAPNDAYGQGYAPQNGYGQPQYGQQGYADYQQPYGQQGYQQPYGQQGYEQQGYQQPYGQQGYQQPYGQGYEQQGYQQPYAQQPYQQQPYDQQGFVQPGGYQQPYEQQGYQQPNPAYNQQGYSQQNPQETDLPPEQQYAQYTPDGQRVYPTSGRSGFRVQPAAHREIPWDTIAKVLMFGVLPILFILSMVFAWTAVKWIVLVGAVASIAAMWLRELVTPNARLVLSLLLASAAVVCLVSALATNAADNQNPAQPNQSGQMQQGSTSGNNLDVNLTATDTPNPAPTPTATPVDDSEECYAQLHSFFTLWKNNAISQMVNLTAPSWRSSIKGGTDAVTQKLFGEVLTNRTPVSWDFTAITGTSNDIARMVTVRAVINKNNTLGESVYLWKVRMVKEDGVWYVDPATLQSNEQESTATPTNALATQPVLNTSHPDLILYYNQNGGTYYHIDPNCASINQRHRPLTASFKWTQIDDEPYKNLEQCKVCGAPLREDKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I943</accession>
    <name>R7I943_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48021">
        <property type="protein sequence ID" value="CDE48021"/>
        <property type="gene ID" value="BN770_01497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435652" evidence="1">
        <location>
            <begin position="23"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="490" mass="52472" checksum="DF6D4ABD8BAABE3F" modified="2013-07-24" version="1">MKKLLAVLLSIMMLAMPLTSMAENSVWDNAARQETTITIHDLNADLVAALGGDDTAMAAINDLLAALSLTGYQQGDEAGFDLNLSGKSVLGMASLTTAAEENQLMYVSSALLGGVIAVNSKDVEAIKEKALRATMKMSGQSDEEIDKAIEESKEQLSGNAEYTALMEASANLGSMTEEQLMEELTQADTTAFMTMMNEILSGAEMAEVTEQPGDCDAAKNYVKVTVPPEKIAEMTKALLEMIHSVPSIGAYMDALFSAADTSWDDLLKELDEADLYADDIVYEYWMTEAGELVRMTASVKINNGGEEPLPMSFTMTRNTADGVATWLVTIKSAEDTAATLTFAGDLENFTANLTAYAGEDSVEINVSGKGVGTDSSVVDVEIKETVDGVEQGFGVVVTTATTMDGEQGVRKVDVLVRFMGLDVVTITAETRTCDAKDALDVSKAQDLGAMTDSEFQTWFVKVMNNLQNLPMTLLMSLPESMLTLLMGGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I949</accession>
    <name>R7I949_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48026">
        <property type="protein sequence ID" value="CDE48026"/>
        <property type="gene ID" value="BN770_01502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="337" mass="37202" checksum="EB0128E88E8417B0" modified="2013-07-24" version="1">MALLEVNDLHTSFFTDAGEVKAVDGVSFRLDHGKVLGIVGESGSGKSVTAYSVMQILAPTGKIVSGSVKFDGQELVGADEKMLRTVRGNRISIIFQDPMTSLNPTYTIGRQLMEAILLHTDRNRHQARERAVEMLKLVNVNEPEKRMKQYPFELSGGMRQRVMIAMALACEPDILIADEPTTALDVTIQAQILDLMRDLQKKMGMAIIMITHDLGVVAQMCDEVIVMYAGSICEQGTADEIFYNPRHEYTKGLMRSIPTAENNGQRLEPITGTPIDLLNMPKGCPFAPRCEAAMKICLKEKPVRMLINDDHMATCWMNVKKGVEDGSITEEGGVPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I962</accession>
    <name>R7I962_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000064">
        <property type="protein sequence ID" value="CDE47798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47798">
        <property type="protein sequence ID" value="CDE47798"/>
        <property type="gene ID" value="BN770_01362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="214" mass="23421" checksum="EBAFCD7FCAD69EDD" modified="2013-07-24" version="1">MIQAVLFDLDGTLTNTIDDIATAMNRALRLHGLPGWETKEYCYLVGNGAKILAQRAVRDRQDLADAVQAEYQAYYEKHTQVKTQPYDGIPELLHALAERGLKLAVLSNKPDADTKNVISHFFPDVPFSVVRGQVEGVPVKPDKAGALLVAEQLGIAPADFLYLGDTKVDMTCACSAGMNPVGVLWGFRTAQELLDNGAKVLIAHPMELLEKFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I966</accession>
    <name>R7I966_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000064">
        <property type="protein sequence ID" value="CDE47803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47803">
        <property type="protein sequence ID" value="CDE47803"/>
        <property type="gene ID" value="BN770_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="321" mass="36381" checksum="D2FA7FA3FF68B1CB" modified="2013-07-24" version="1">MRWTVYTPEKALKLLSFCTLDAPESELRHQAEAAGFPWQSPFQEKTRWESFLRFFRDKLYDGCRHQAAYSAARAYYEEKLPEGAACFDMGYSGRLQAAICQLTQRAVPVYYVHADGRNSERLSAAYDFPVHCFYPMPPAMSGAFREFLLSSDEAPCVGFERQNARVVPVYAQEGRNEAAHFLSTCVQHHALQFVRDFRDTFAGTGVMQSLDNPGVQLAMSLPFEGALRQLPEADAELLRNIPFEDMVFAGENALDLRTLVRDQSAEAALAAHEMGAADAPSRMIGFIPEQTGLVKRTIGFLLFDRETFRKKLRKRMHRSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9N7</accession>
    <name>R7I9N7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48604">
        <property type="protein sequence ID" value="CDE48604"/>
        <property type="gene ID" value="BN770_01745"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="278" mass="31366" checksum="BC626203DB0395E0" modified="2013-07-24" version="1">MQNVGVVGLGLIGGSLAKTIKLHTPYTVYGTDKNADTMRRAFLMEAIDGELTAETLPQCDVVLVCLYPQGIIDYVTAHAADFKPDSLVIDCGGVKQVICDALFPVSQRYAWHFIGGHPMAGREYSGFKYARDDLFDHASMILCGHGDDDPAVLQRARDFFMKLGFLRVQFTTPKTHDEMIAYTSQLAHVVSSAYVKCPLADKHRGFSAGSFADMTRVARLNEDMWTELFFDNREALLPVVEDLVQRVTEYRDALRDENREEMRKLLREGRETKERLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9Y7</accession>
    <name>R7I9Y7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48113">
        <property type="protein sequence ID" value="CDE48113"/>
        <property type="gene ID" value="BN770_00122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="53" mass="5848" checksum="670CE76BDE4F483F" modified="2013-07-24" version="1">MSNEKSHTDEARKSVHRNCVSADASAFDLFSIIAPNGRDQTHRLLTSTSRTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA11</accession>
    <name>R7IA11_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fructose-1,6-bisphosphatase class 3</fullName>
            <shortName evidence="2">FBPase class 3</shortName>
            <ecNumber evidence="2">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fbp</name>
        <name evidence="3" type="ORF">BN770_01703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FBPase class 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000108">
        <property type="protein sequence ID" value="CDE48440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48440">
        <property type="protein sequence ID" value="CDE48440"/>
        <property type="gene ID" value="BN770_01703"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01854">
        <property type="entry name" value="FBPase_class3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009164">
        <property type="entry name" value="FBPtase_class3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06874">
        <property type="entry name" value="FBPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="658" mass="75322" checksum="BF033A97565BCF1D" modified="2013-07-24" version="1">MREYTPERLRHLTLLAEKYPTALSAYSEIIRLEALLRLPKGTEHFMSDLHGEHEAFIHILNSASGVIREKIDRLLGDTTPPEERADLATLIYYPREKLPELKARQNDLDGWYQRVLLQLIDLCRLVSSKHTRRHVRAVMPKECGHILDELLHAHFEDHDKEQYYGEIIASMLRYGLADQYIIALCEVVKRLAVDRLHIVGDLFDRGPRPDMILERLYQYHDVDFQWGNHDVVWMGAAAGSPLCILTVLKTTLAYNNVDTLERGYGIPLRCLEHYAEEYYAQSDLTRWMPHADPNATDVRPANLARVARMHKAVTVLMLKLEAEVIARNPDFEMQGRDYLRQIDYDAGTVRCGGKVYPLLDCDFPTVDPTAPERLLPREEDIIARLVRDFKGSEKLQKHVEFLFSQGSVYSCVNGNLLYHGAVPMDEDGQFTAVRFWDAEYSGKRWFDCCDRCARMGYFAPEGSWQRQVGQDFLWYLWCGAVSPIYGRSAMTTFERLYIADPATHAEIKNPYYRLINDPANVERILAEFGLTAPNSHIVNGHVPVRAIEGEKPVKGGGKLIVIDGGFCSAYHQKTGIAGYTLVYNSHGMTLRTHQPFESIEKAIHEDEDIESSSERIYTAPRRILIGDTDEGQRKRTEIDDLEALTEAYGNGLIREKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA44</accession>
    <name>R7IA44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47392">
        <property type="protein sequence ID" value="CDE47392"/>
        <property type="gene ID" value="BN770_01237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="304" mass="32479" checksum="3B3662D2DAAB5829" modified="2013-07-24" version="1">MEKKAIRVAYGEAIVKLGAENDKVVVLDADLAAATMTNGFKKAYPDRFIDCGIAEANMVDMAAGMSTMGLIPFCSTFAVFAGRSYDQIRNGVCYPKFNVKFGFSHAGITLGEDGGSHQAIEDIALMRVLPNMTVFVPSDATECEQCVRAAAEINGSVYIRTARLPSPVYDARPFTVGKGNVIKDGKDCVIFTCGIMLEHCLEAVQLLAEQGIDAALVSFHTLKPFDDELARTYAAKCGKVFTVEEHSIIGGLGDAVASAICGMGLKHFEKIGINDVFGQSGKPAALLEEYGLTGKQIADRIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAA7</accession>
    <name>R7IAA7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal-type GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000105">
        <property type="protein sequence ID" value="CDE48421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48421">
        <property type="protein sequence ID" value="CDE48421"/>
        <property type="gene ID" value="BN770_01695"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010551">
        <property type="entry name" value="G6P_isomerase_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06560">
        <property type="entry name" value="GPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPI" evidence="7">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="185" mass="20123" checksum="438A55561837AB46" modified="2013-07-24" version="1">MNGTMVDLLSGYLIGDNISESKRTLGDLKNVFQNEAVRAQMNPATIVYEVQSHMAVKDGTPGGLFFGTSNVMPGQVGGEYFMTKGHYHARRECGEYYWCIQGTGALILMDESGKCWFEPMQPGSLHYIPGYIAHRLANTGDTPLRVGACWPSDAGHDYASIAEHGFTARLMNVGGVPTLVQEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAH9</accession>
    <name>R7IAH9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48268">
        <property type="protein sequence ID" value="CDE48268"/>
        <property type="gene ID" value="BN770_01612"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="499" mass="53816" checksum="0AE33CC54FB8478F" modified="2013-07-24" version="1">MSFISTRGGACVTASQAILRGLAPDGGLYVPAVFPQMTLADIAALTKLDYRARALTILRGYLDDFNAQELADAIASAYEAAKFDDAAIAPTKKLDSNTHVLELFHGPTLAFKDMALQLLPHLTTLSAKKNGENREVAILVATSGDTGKAALEGFKDVPGTSCTVFYPTDGVSDVQKLQMTTTGGENTHVIALNGNFDDAQSGVKALFSSEDFHQQVNARGKVLSSANSINFGRLVPQIVYYFSAYADLLNAGAIALGDEVNFVVPTGNFGNILAGYYARSMGLPVKKLICASNRNNVLTDFFLGGVYDTRRQFFKTTSPSMDILISSNLERLLFECADRDGALIARWMQQLRTSQSYAVGQQRQEWLLSVFAAGYADDRDCAEEIARVFEQHHYLMDTHTAVASRVLRQYRETSGDLTPTVIVSTASPYKFAADVLTAVAGKNAVAGLDAFACSDELEARSGMPVPQQVKALRSLPIRHTAHCEKGGMAQAVLDAFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAL7</accession>
    <name>R7IAL7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Leucine Rich Repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47557">
        <property type="protein sequence ID" value="CDE47557"/>
        <property type="gene ID" value="BN770_01282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="PTHR23019"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435642" evidence="6">
        <location>
            <begin position="26"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="216"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="300"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="384"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="7">
        <location>
            <begin position="468"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="680" mass="72321" checksum="CC09C50032CA99E7" modified="2013-07-24" version="1">MKNFWKIVMLTVLCVSLLCGVTAMAEADRFQFEKTNLTVFEGNTLELSLIRQGNCAADGELTFVSGRENIATVDENGVVTGLTKGQSTITATLKTEKRTWKASVTVTVARAVTDIAVNETSLTLYDAADPLISHLTGGADGRVLLLRKGKQVSIRATLSPNDANNRRYTVASSDTDVVRASGSTLTARGAGECIVTVASESNPEVSVDYRVIVITPVTGVTVTADTKTLFIGTTAQLTATVKPADASITGVKWESTNEKVAVVDEYGVVTGVGRGQATIRATAADGGGQRASVNVTVKQQPESITLSGLSGNIRVGGGVTLKATVLPNTTSDKAVVWSTSDASVATVSANGYVKGVRAGSCTITCQSKTFPEVYAQIDVTVYAPVTSITFNEKKPSVAVGRSIALSWTVKPQDATDSSVSFSTNKPDVVSVSDDGIVTGLKRGECYVYATANDGSGKKATIRVTVTQPVTGVTMKYTSQNVGLNKYTTNTAILEPANADNKKMQWTSQDERIATVSGNGLNPKVTGRAWGTTTIIGTTDDGSYVVTYTINVGSRKDALRITNLWAENNAAKIVVYNASNLTITKFYYTIYLYNAFGEPLVCNTDGRSFSFTGTYNFTLAPGEATRHGQFSFGREYIKPYGVGQVVMRINGYDIEGGEHYDIPANDQPEFTWKATIDDGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAP0</accession>
    <name>R7IAP0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48645">
        <property type="protein sequence ID" value="CDE48645"/>
        <property type="gene ID" value="BN770_01766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="160" mass="17307" checksum="E604A435BC5E66E9" modified="2013-07-24" version="1">MAKATKTNVLRHLDALKIPYETREYTVDDDNFDGKLVAEKVDLPAEMIYKTLVLVGDTLPHLVCVIPVELELDLKAVARAAGCKSVHMLPQKDLLPLTGYLRGGCSPIGMKKAFPTFVDSAAQHLERVSVSAGVRGCQVILAVDALVACTKAKFADLCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAR5</accession>
    <name>R7IAR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000101">
        <property type="protein sequence ID" value="CDE48378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48378">
        <property type="protein sequence ID" value="CDE48378"/>
        <property type="gene ID" value="BN770_00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="239"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="302" mass="35019" checksum="C5E60D3CEA6B666F" modified="2013-07-24" version="1">MNRVREASTMSVPTMRQMLGLKKTASYWLIKKQWFDVLIIHGEMRVVISSFETWYANQTHYRKVNGPPPGEELRKKSYSVKDISNLLGIGIDTVYDLIHREKIPYSVYQYGQWRVDAAVFQFWYNSQCTYHLVTAEHPNELHKANLMKLTEFGRLLGLERDETYKLVRQLKYVLEIVSINRQLYVTMSSYQRWRETETRTDAEIAASVAKRSRKELPQILPAVSSVEQESPSIPAQKFFTVPEAASFLHLSERTVYRLCSDGRIPAKRVASQWRIARADLEALSNQNSINQQGEEANGDNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB67</accession>
    <name>R7IB67_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48810">
        <property type="protein sequence ID" value="CDE48810"/>
        <property type="gene ID" value="BN770_01829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="59"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="396" mass="44301" checksum="C631CAE5FFB2DF05" modified="2013-07-24" version="1">MHTFDESYFDAGLDRRGTRCEKWDGTEKESVLPLWVADMDFPSPPEVAEAIAVRALHPTYGYTLVLPDDTRALTGFWQRRHNLTIQDEWVMMIPCVVTGIRLALLALTKPGDGVMIQSPVYGPFRFSVEATERRLMDAPLKRDDTGRYSMDLDAVEKQLQAGAKALVLCNPHNPVSRAWKREELQALIDLLARYGAYLIADEIHADFVYAPEQFVPVLSLAQKNVLSLCAASKTFNLAGLEQAAMLVPDEAVRAKINTEMERAGVRSGNLFALEGTRAAYEYGDAWLDGLMHYLDGNRKHLTALVKQELPQAVLTPMEATYLGWLDLRAYGMNCEELMARTLKHGVQFTEGTFFGEGGEGFLRVNIGCPRRNIIEGIHRLKEALDEAVEEKAHGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB96</accession>
    <name>R7IB96_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47762">
        <property type="protein sequence ID" value="CDE47762"/>
        <property type="gene ID" value="BN770_01344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="135" mass="14014" checksum="FA56AFF8514E9020" modified="2013-07-24" version="1">MKSLLTNRKAGVYVLIVSILLQLVSAVNYLVWAPGAGGIDTLVALGLGIGCLVGIAAFLFSSDLLLVADTALCSCGMLQLAVSSAGSFADWYQGIVMFGDPSQVPRILTICILALTAVVLLIITGFMGFGKQETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBD9</accession>
    <name>R7IBD9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase family IB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47812">
        <property type="protein sequence ID" value="CDE47812"/>
        <property type="gene ID" value="BN770_01373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24590" checksum="9CD32B3BEBFCD880" modified="2013-07-24" version="1">MTQGIAFFDFDDTLARGDSILPFLLYCIRRGIAPRRQLIKAAGAFLYWKLRPSQASRAKSATLSFLKGRSADEMLDVARAFFRDEYLPRFYQDGLTELWSLRSQGMKLVVVSASPDVYMRALPEFMPIDAVLSTRCEVGGDGRYTGQVGENCKGEEKVRRIEQYLKENGFVLDMKCSSAYGDSPSDADMMALVNRAVLVNPKKALLRRRPDGIVVHWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBH3</accession>
    <name>R7IBH3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47852">
        <property type="protein sequence ID" value="CDE47852"/>
        <property type="gene ID" value="BN770_01389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="361" mass="40174" checksum="0FA1E207F52D1E3C" modified="2013-07-24" version="1">MEKYRVGIVGATGMVGQRFISLLKDHPWFEVNCVAASARSAGKTYREAVGERWAFSWEIPEKVAGMTVVDAADIDEVSKHVDFVFCAVDMKKDEIRALEEAYAKHEIPVVSNNSACRGIEDVPMVVPEINADHLAVIEAQKKRLGTKNGFIAVKPNCSIQSYVPALTPLLDFEPEKVSVCTYQAISGAGKTFKTWPEMVDNVIPYIGGEDEKSENEPLKLWGHVEDGKIVNATLPVISAQCLRVACPDGHMAAVSVSFKKKPTIEQIKERWANYETEAQRLELPSAPKPFLQYFEDPSRPQTRLDRDFQNGFGVSIGRLREDKLFDYRFVCLSHNTVRGAAGGGILTAELLCRKGYIPHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBI4</accession>
    <name>R7IBI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48668">
        <property type="protein sequence ID" value="CDE48668"/>
        <property type="gene ID" value="BN770_01779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="345" mass="37501" checksum="3892575855B052BF" modified="2013-07-24" version="1">MDVKKLLADVTALPGVSGHEAQVSAYFAEQFRPLVDEVTVDAMYSVIAHKKGNGPKIMLCAHLDEIALMVTHIEDDGSLRLGNVGGVDPRILPASRVWVHGREKLFGTIGALPPHLMSAADRANNYTLDNLHVDIGMSAERAKELVRIGDLVTFDGPARELLNGQFASKTLDDRSCVAILLRAAEMLQKLVCDADVYFVCSSQEEVGGRGAMTSAFAIDPDLSVVLDVDFAETPTCPPRSALPIDAMIVTHGPFVQPKLNQRLIDCAKKHHVKLNANVARRSTGTDADEIGLSRAGVPSVLLSLPEKYMHTSVETIDLNTLEEGARLLANFVAELDESWEDDLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBR0</accession>
    <name>R7IBR0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Site-specific DNA-methyltransferase (Adenine-specific)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49324">
        <property type="protein sequence ID" value="CDE49324"/>
        <property type="gene ID" value="BN770_01972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="118" mass="13515" checksum="CB276F262943BC54" modified="2013-07-24" version="1">MLVDVDKKAHQVEEANCRKLRMDDRCRLLLMDWQAAVSQLQCADDRFNLVFLDPPYAMHDLCGVMNALKPLLAEDAIILVEHEAKTFPSTPDGFDLYDSRKYGIAGVSFFRLIHTEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC96</accession>
    <name>R7IC96_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000144">
        <property type="protein sequence ID" value="CDE49504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49504">
        <property type="protein sequence ID" value="CDE49504"/>
        <property type="gene ID" value="BN770_02032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="236"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="656" mass="74126" checksum="88F71A721372C0AA" modified="2013-07-24" version="1">MIYYVNQAMLHDGDGSLGTPFRRISEAAKIAKPGDEVLVFPGVYREYVNPERGGTEDAPILYRSIEPLGAVICGAERIKGWTPYQGTVWTVRVKNSTFGAYNPYTTEVFGDWYFAPTVRHTGAVYLNDQMLYEAESLEECIAGEIYKPSWDPQGSTFKWFSEQDGDETVLYANFHTQDPNREKVEINVRRRCFFPEKTGCGYITVHGFKIEKAATTWAPPAAFQDGMIGPHWSKGWIIEDCEITNSKCCGISLGKYYDPENDHYFTKKHLKSPTQMERDAVCRGQYHGWLKENIGSHIIRRCNIHNCEQTGIVGRMGAVYSVIENNHIHHINNMQELGGAEISGIKLHAAIDVVIRRNHIHDCTMGVWCDWEAQGTRITQNLLHHNERPAYCTWAVGGMESQDIFVEVGHGPTLIDNNIMMSKVSLRFATQGVALVHNLMLGTFTCVGGGTSWRYTPYHIRHRTEVAGFMTILHGDDRFYNNIFVQAHPVDAPAKQGDPGENERVVGTWCFDDYPTKQEWLDQFDLDVARPDMGKLEEYHFGHLPVWADGNAYFAGAKPWKKEKDCCVKSEKPYFMLVEREGQIFLDTDVAELIGAFRGGLVDSDTLGRAFEPDQRFEAADGSTIVFDSDFYGNHRGARVLPGPFATLDASMQPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICI4</accession>
    <name>R7ICI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49295">
        <property type="protein sequence ID" value="CDE49295"/>
        <property type="gene ID" value="BN770_01962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="292" mass="32101" checksum="A506150162AFD630" modified="2013-07-24" version="1">MSTSYTEKTHSAFHGAPIDTSDPKTLAWLIRRHGLEMTHISRGSHIGAIFSVAEIMAVLYTRILRVDPKNPQWENRDRLILSKGHAGASVYAALAERGFFPVEELSTHYANGSRLSGHVSHKGVPGVEFSTGSLGHGLSVAAGMALGGKKDNADWRVYCVLGDGECDEGSVWEAALQAHQYKLDNLVAIIDHNRMQSLDFCENTLALEPFGDKWRAFGWNVIETDGNDVDAVEKALRQAQENRGSGRPTVVIAVTTKGKGVSFMENDILWHYRTPQGEEYDAALAELEAQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICK0</accession>
    <name>R7ICK0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycosyl transferase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_01943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49221">
        <property type="protein sequence ID" value="CDE49221"/>
        <property type="gene ID" value="BN770_01943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436382" evidence="9">
        <location>
            <begin position="30"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1212"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1305"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1352"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1379"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1410"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="11">
        <location>
            <begin position="1251"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1451" mass="162102" checksum="1850731CF6201F82" modified="2013-07-24" version="1">MKRNRLARRPLLLLLSLLMLLGIFSTASAEESTNLLQNPGFEEIGADGLPVGWKTDAYLNLEGVTFYTVSDNAMSGAHSVQIENLDYNDARFCQTVAVEPSSFYRLSGYVKAWDTLDEGLGGNLSIKDVYVFSESVYDSPDEWQYVELYGVTDTDQHEVTVYARLGGYSGESFGTAMFDDLSLVKVDAPPEGIVASRWYQPTAAVQDDPSDDLADTAAASPAWPWMTAVGIAYVALGVYLLRFLQKKDAVPLDAKKREAMPLFAIIGLIIAAAARLIVANSVSGYQVDVNCFLAWGNTLLSVGPANFYQTTNFCDYPPAYVYIMGLNAALMRVLPLSAAAVHKLIPMACDLVAAVLTYRIVRKKNASANQAGILMLLMAFNPAIFLNSAAWCQIDSVLSLLLMLVAYFAVCGNWMAVMPIYMLAVLVKPQALMLGFLGLAAIVMALIRDRKCWKPMLIGVGLAVVTAVIVVLPFSVNQGGISWLIDKYAQTLSSYPYATVNTANFYYLFGCNWTSIVMEAPRAVPLLLMALSLVWTGWLIYRAQKSGWQPDVLTGLMTILLIIGGFGLGGFFATQSGWTRTMIFHLGGSMVLSRTALLVVGLVGLAGAIALGVMLFKCKKADWNSAEIAAGLTFALIFLGLATFNASFTMVGLVAMALPFVMVLPMFIRSGKLENLALCGSVLFVLLYVFGIKMHERYLFPALFLLGMAYAGRRDRRTLVLLLGLSATAFINEGIVLDNSLRLGSSLGHLNNDTVVLAMLLSAANVALAFLGVWTCRDLCLPVSAADETLEHPAYLPVKQLDKKPGDPRTFKQDVSLHWRKRDWLLMLGVTLVYAVVALTNLGSMKAPQNPWVSSTRNEQVIIDLGEHHDDVTMLYFCQVSYSNFSVAVSEDGESWSDDYIADMAEGECFQWKYLTPSYMGKDKYGNDKRFFYSQPIKFSARYVRITSQQIGLKMNEVIFHDTNGDRIPATVIAQLNVMEESTLYSDANNIFDEQDTLEGLPSWWNSTYFDEIYHARTAYEHLHGTVPYETSHPPLGKVIMSLGIAIFGMVPFGWRVMGALAGILMLPAMYLLGKQLTKKSSFAFAAALMLALDCQHFTQTRIATIDSYPVLFILFSWLFMLRFMQRDIVRLPVKNLLPDLALSGLFMGLGIASKWIGVYSGAGLAVAFFWTIFRHMRMAATSAHLLKTDKSLSDEDRKILTLRDQTTMKRVLVICLWCLLFFVAIPLAIYLLAYIPYFAYAHFDNLKDYLTAVWNAQLSMFSYHSKPGLGMDHPFYSPWYEWLFNQRPMYYASPTYVNTPGWSYAIWCFGNPAIWSAALVGFAYTVFMWAKRHRYTLRKDGETLHWTAADWDVTMPFLLLSALSQFLPWVLVPRGTYIYHYFATTPFLMLSITVLFRDITRRFPKTGKWLLGIFLGVCLVMFVAYFPYASGALTPTWWLDFMEQFLRIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICP4</accession>
    <name>R7ICP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48257">
        <property type="protein sequence ID" value="CDE48257"/>
        <property type="gene ID" value="BN770_01604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="289" mass="31998" checksum="57B971DE54EF6DD2" modified="2013-07-24" version="1">MAKAQRTGVIRDYDMHSASVRVGYGFIIFFCLIMTVIAVFPIIWVVLAGFKDLKEFMSSVKLLPEVFDFSLFAKTWSQLGIAQNYLNSLISVAGSVVCAIVFNGLLGYGLAILKPKGYGIVKKLVMLSLLLPTTISIVPLFMNIQKLNLGGSFVPLWLSYGANAMYVILFVQFFESLPTSIIEAGRIDGCTQLETFFYIVLPLSKPICSVIAIFAINAAWSDFLLPYLVLRGSALQTVMVRLFVFSTEQTVNADTMMRSVVFSMIPPIILFFIFQKQLTENAVSVGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICS2</accession>
    <name>R7ICS2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000150">
        <property type="protein sequence ID" value="CDE49684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49684">
        <property type="protein sequence ID" value="CDE49684"/>
        <property type="gene ID" value="BN770_02089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="42" mass="4727" checksum="82F4889443723D3A" modified="2013-07-24" version="1">MSLQTQVQEFATSSDHDAEYFANKIVNILKEAGVKGEWNLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICS4</accession>
    <name>R7ICS4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49420">
        <property type="protein sequence ID" value="CDE49420"/>
        <property type="gene ID" value="BN770_02009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="169" mass="19315" checksum="528C217E9AF9EB8A" modified="2013-07-24" version="1">MKMTSAYANKLLRQLNEEKEFLLNQEENSCTYVYAADEEPLIPQYSYPQTEAQLRALDAKIVKIKHAVNCSNVSTSLMLSSGRVLTVDQALVVMAQLSQRKQQLDTLRKRQPKARNNDHYGRSGATEYTCINYDLADVRKAYEAISAEIMEIQMKLDQLNQTVTFDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICW5</accession>
    <name>R7ICW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000101">
        <property type="protein sequence ID" value="CDE48377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48377">
        <property type="protein sequence ID" value="CDE48377"/>
        <property type="gene ID" value="BN770_00137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="59"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="172"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="466" mass="53129" checksum="B73C5C35F6A0B767" modified="2013-07-24" version="1">MATIICKNNKFNVVYSYYDEAGKRHQKWEAFPTMPEAKQRKSEIEYKQQLGSFTIPTCNTLNELLKEYVSLYGKTKWAINGYSSNTGLIRHYIAPKLGELRLKEITPRVLEMFYQGLLKTPAVPLMTDKKYRQTGKFVQPPTIRKIHNLLHSAFKQAQKWELIEKNPAEFATLPKYEMKERNIWDSQTLFHAIDCCEDERLKLCLNLAFSCSLRIGELLGLTWDCVDISEESIAAGTAHIVVNKQLQRVNKRSMEATDSKDVLTTFPEIGLQNNTVLILKKPKTRASIRKIFLPKTVAENLTKWKMEQDLLIEQLGAEYHDYNLVIAGSRGQPVESNIIRKSMRQLIEANELPQVCFHSLRHSSITYKLKLNGGDIKAVQGDSGHAQATMVTDQYSHILDESRRNNVQLFEQAFYGGKGVKIVPEAQDKAVEEQVQQAGLNSEVLLKIFSNPDMVAMLKMLAKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID04</accession>
    <name>R7ID04_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lexA</name>
        <name evidence="16" type="ORF">BN770_02038</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="CBJB010000145">
        <property type="protein sequence ID" value="CDE49520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49520">
        <property type="protein sequence ID" value="CDE49520"/>
        <property type="gene ID" value="BN770_02038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="84"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDE49520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="203" mass="22824" checksum="37C89D7333C08C44" modified="2013-07-24" version="1">MQRPRGDNQQRILDFIKSEIQTKGYPPSVREIAQAVGLKSTSTVHGHLQRLEKRGLLHRDAMKPRAMEVTGDPNFIRNNSTAVPVVGRVTAGQPIFAEENLEEYVPIPDIMLGEGEHFILHVKGDSMIEAGILDGDYIIVRKTSEALNGEIVVAMIDDSATVKRYFKEDGHFRLQPENRTMEPIYADEVTILGKVTSLYRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID91</accession>
    <name>R7ID91_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpD</name>
        <name evidence="5" type="ORF">BN770_02004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49411">
        <property type="protein sequence ID" value="CDE49411"/>
        <property type="gene ID" value="BN770_02004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="213" mass="24308" checksum="E12CD8227A67E413" modified="2013-07-24" version="1">MPTALRVNPTRMEMTRIKKRLVTATRGHKLLKDKRDEMVRQFILLIRENYTLRREVEAELSGALRDFAMARAVMSPQSLEAAVLYPARQAELHVSERNILSVHVPTIEADQASLETTVQSYGFAETSAELDGSIATLASVLPKLVRLAEIEKTCDMLADEIEKTRRRVNALEYVMIPQFEMTIREISMKLEENERGATTRLMKVKDMMAKRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDB4</accession>
    <name>R7IDB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49436">
        <property type="protein sequence ID" value="CDE49436"/>
        <property type="gene ID" value="BN770_02016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448184" evidence="1">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="135" mass="14750" checksum="E965E43D14E90442" modified="2013-07-24" version="1">MMHMLRRVFAVLLVLAALLSCAFADDSVEPCADVTFLSATCSLGMDKVATFTLMTDILAGRIVVTNAWLEQQSNGRWVYVKPLAVPATIATNTISYSATLSYSSAITTRGTFRIGFTADADGHQITRYSNSRRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDC0</accession>
    <name>R7IDC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49799">
        <property type="protein sequence ID" value="CDE49799"/>
        <property type="gene ID" value="BN770_02147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009570">
        <property type="entry name" value="Spore_III_AC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025664">
        <property type="entry name" value="Spore_III_AC/AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06686">
        <property type="entry name" value="SpoIIIAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02848">
        <property type="entry name" value="spore_III_AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="65" mass="6802" checksum="DDA25E8AB21711E9" modified="2013-07-24" version="1">MQLDLLFQIAGVGILTTVVASVLNSSGRSELANLATVAGLAIVLLMVVSLLSQLFTNVRTIFQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDQ2</accession>
    <name>R7IDQ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="5 10 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisA</name>
        <name evidence="13" type="ORF">BN770_02207</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="5 10 12"/>
    <dbReference type="EMBL" id="CBJB010000158">
        <property type="protein sequence ID" value="CDE49954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49954">
        <property type="protein sequence ID" value="CDE49954"/>
        <property type="gene ID" value="BN770_02207"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE49954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="242" mass="25936" checksum="52D325438AED8BF8" modified="2013-07-24" version="1">MQLYPAIDMLDGNAVRLRQGRRDDVTIFGNPVDLAAKWREQGATYLHLVDLTAAFDGQTKHLPLIREVIRAFGGNVELGGGLRTMADIALRIEAGVTRCIIGTAAIEHPELVKEACRAFPGQIAVGLDAKDGFVATRGWVETSTLTAAEVALRMRDMGVSTLIYTDISRDGMMQGPNFAATKRLIDKTQMDIIGSGGVSSISDLLKLQEIGCAGAILGRAMYEGAFTVPDALEAIQTADKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDY8</accession>
    <name>R7IDY8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ORF">BN770_01817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48767">
        <property type="protein sequence ID" value="CDE48767"/>
        <property type="gene ID" value="BN770_01817"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="196"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="224"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE48767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="513" mass="56301" checksum="AB1A995E679157F2" modified="2013-07-24" version="1">MAETQKIVILNFGGQYTQLIARRVRECHVYSCVLPYDASLETIRAQNPVGVILSGGPASVLEQDAPRCDEGVYQLGVPVLGICYGMQLTAYLLGGTVEKAAQREYGRITVTMDDKTSLLSGMSDASSCWLSHTYQVKKCPAGFHPIAHSTNCPVAAMANDDRRIYGVQFHPEVTHSDEGRAVIENFLNICGCVGDWSMETYAQTAIANIREIVGDKGTVLLGLSGGVDSSVAAALIYKAIGDRLTCVYVDHGFMRKGETEQVVNVFTHTFPVRLVASDASKIFYEDLKGVSDPETKRKIIGRDFLKVFKAESEKLGKLDYFAQGTIYPDVIESGQATGAAVIKSHHNVGGLPKELGFTQLIEPLRMLFKDEVRALGETLGLPHDLVWRQPFPGPGLAIRVIGDLTPEKVEIVRESDAVLREEIAKAGLDADIHQYFTVLTGIRSVGVMGDERTYDYTVAIRAVTTDDFMTADWARIPYDVVRTISARIVNEVPHVNRVVLDVTTKPPASIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDZ8</accession>
    <name>R7IDZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50054">
        <property type="protein sequence ID" value="CDE50054"/>
        <property type="gene ID" value="BN770_02255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448196" description="NAGPA domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="2">
        <location>
            <begin position="126"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35101" checksum="A24FB34E59F15D61" modified="2013-07-24" version="1">MKYLRKLIAACALLAMLCPALAEETTYEPLPWLDSTGRKLLAAPYLPNPDCYLPDQGGYHDDSLDIRVETSYWTQDIERVDEPGEGTTTVMAVYVKITDPTQIRTALAFPYPSKNTVRVERMAKQNNAVLAINGDYFIYHSEGIVYRNTHRLRELPREYRDTMIIDTEGGMHIIQGTTHQKWQDYLENGGTVAHTFCFGPGLVIDGVVRDEFDSRMDNGPKTLAQRMIFGQITPMEFVILCTEGPESQSPKSIGFDLWGAAKLAGAFGLQNAYNLDGGSSCTVVLNNEKINSPSNPKRREVGDCIYFATLIPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE72</accession>
    <name>R7IE72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YigZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49721">
        <property type="protein sequence ID" value="CDE49721"/>
        <property type="gene ID" value="BN770_02103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="142"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="215" mass="23683" checksum="6BD6C63F39A0DA4C" modified="2013-07-24" version="1">MSALNPYRTLRQFASDEFIINKSRFIGYAAPCETEAEALAFLQSIRTKHKDATHNCYAYIIGQNAGIMRYSDDGEPGGTAGLPMMEVLKHQGVVNCCCVVTRYFGGVLLGAGGLVRAYTQGAVVALKAAQVVEMLPSCQYLCEVAYPLWDKVQYALKSLPVQLLSSEFTTAVGFTLLIRQTDAQSVLDTLTRVTDGRIETLLEEESYRAWDSESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE78</accession>
    <name>R7IE78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin-requiring enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49726">
        <property type="protein sequence ID" value="CDE49726"/>
        <property type="gene ID" value="BN770_02106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="279" mass="30313" checksum="94C8D68B7E6839EA" modified="2013-07-24" version="1">MKKTGKIIAIIVVLALVVSGVFLFAGGRKNAAYSEEIARTQDISTYYTFSGNLSTKDSQIVTSTAKTTVKECLFSEGDAVKKNDIILKFSSGGTARAPMDGTLSNLYVEEGDEVTMGQQLLRVADYSNPQIVFNVDEYDRPALSVGQAADVTVLSTGKMLTGTITRIAQEATVSGDLAYYEVTMTVPQDGTLAMGLSCEIRVLYQSVKNVTTVSIDAIQYDSDGKPFVYCYDRKDDIVQQRVTLGINNGSIVEIVDGIRTGEAVLIPVKNTMEMPMMHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEB0</accession>
    <name>R7IEB0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_02304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50159">
        <property type="protein sequence ID" value="CDE50159"/>
        <property type="gene ID" value="BN770_02304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="240" mass="25853" checksum="24529D3CD8159C73" modified="2013-07-24" version="1">MLTIFLRSVILYAASLLAMRAMGKRQVGQLQPFELVVVIMIAELAATPMGGVGIPILYGLLPMAALVVCHGLLTALCMKSERVRVWLCGQPTVLVRNGVICEKQMRACAVDLNDLMEAIRAGGILDPLEVGTAVLEPGGNISVFPKADSRPLMPSDLGKMPPKEGLPLPLILDGEVQTENLQRGQLSLSWLMGQIRALGFEGAQDVLLLCLNTQGMLLAQGKGRTQVQTHQALPPQKVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEB2</accession>
    <name>R7IEB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Anti-sigma F factor antagonist</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Stage II sporulation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49741">
        <property type="protein sequence ID" value="CDE49741"/>
        <property type="gene ID" value="BN770_02114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045152">
        <property type="term" value="F:antisigma factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014237">
        <property type="entry name" value="Anti-sigma_F_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02886">
        <property type="entry name" value="spore_II_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="108" mass="12193" checksum="5931AB697ABC1A93" modified="2013-07-24" version="1">MLQSIRDGDRLIVRIGGELDHFCAQSVRRDLDALLLDRSVRTLILDFSSLTFMDSSGIGVVLGRYRLLRDRGGHVAIVGMNPHIARLFHMSGLDRIIRQLDKHQEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEQ0</accession>
    <name>R7IEQ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50110">
        <property type="protein sequence ID" value="CDE50110"/>
        <property type="gene ID" value="BN770_02284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="31" mass="3649" checksum="D48D94734C68CFF4" modified="2013-07-24" version="1">MKKSKAKKHGKKPLFAPIKVKRRMSRERPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF71</accession>
    <name>R7IF71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49983">
        <property type="protein sequence ID" value="CDE49983"/>
        <property type="gene ID" value="BN770_02215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="139"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="471"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1209" mass="136976" checksum="9A01A1100C5A4581" modified="2013-07-24" version="1">MSRKCSDQFYYAVRIGRKPGIYRGWYGEYGAEKQITGIRNYDYSTGYLKTSSWEDADAYMRTHELFVVESDFTIKEATSFKEDMSVVYGEAHVAAKETPAQPPAAPATENVFFSPSAPSVPYHRDEKLESFLHAYYPDRRFTDDQKAAIQALSGAHLLYAIPGSGKTAVLTARAGWMIHCGIPAENILIMTFGKKAAEHMADVFRERFPSFSVPFFCTIHSFCYRIIRQAEAEGLIKKYSLIVDEEDDPVPEAMDGETANAWIVDESPDEVPSGRTKREDKKKGNRYANPRSPIYLLEKILTKLEYCKKQSEARTFAEQAATVIGCLKNRMMTDEEILRPLPINMGADKRVSIWPVYEAYQKELAEHQPPEMDFDDMLIHALEVLDNPNMQAFWQRKYPYVCVDEAQDTSLLQHAIVQKLHRTGDSLFMVGDDDQSIYAFRGAMPEAMLAFDRRYEDAAVHRMGVNFRSDQQIVLSGDGLIQRNKARAKKTMEAFSKQPGEIRIIDISAAMQGQFLLDQARRFCKKQEGGENPESLAILYRNNVSALLPLAYFFKNDVPFVGNKVFDVLTLLYSRTAINILAFLCFVLEPDSFQAYSSAYPVWNHYHGLFLNRETAVENLRKQMGEENSGGPILPKLQALLRSLGEMDKARHIGEIWTILQRIQAEDKPDFAIMAMLKELEYNKNGSIKQKNVQLLVMALIRIASLYDSILSFVEAMLALRTKRKWDEHNADKHPVVTLSTMHSAKGQEYDHVIIIDAVEDLMPGDPSKPLPFWHASWQDHVEEERRLFYVAATRARHDLRIVVNGLNSSSPKAPSPFIHEMLRDNPNIPVEKLAADDALEEQIEEAMGIPYFAVRRGKTPGIHREYEKAGVEGYSCPVYRRCTTWRKANRFLNKAVSCPVPETETAPDLPLPVEKALLRLFSVQQLKELDANRLKKIRQKTGYLFSKEAIAAKAVDYAACAPEYALIYLPVNLHKVWQPLIELLRDEMLPLLDEFKYPDGAHPIRILEMGAGPGTATIGLLSFYAKIAEANPSLEIHLEYLPVEYERAFRPIFEALTAAMLSTLPANLHICMKPMQISDAFAFLHTCQADSFDLILESNMLNHNEHVESRLLNGLLHDMNRTLVYSGKVIAIEPADEETAAFLVQLAGLAEKSCGFGVMEPKSESAACDVSGIRLYQEAVACGLRHPLEKDCHRFRYTVLTKKQEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFN3</accession>
    <name>R7IFN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50430">
        <property type="protein sequence ID" value="CDE50430"/>
        <property type="gene ID" value="BN770_02385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="464" mass="52957" checksum="43C6EC9693BC128A" modified="2013-07-24" version="1">MLEFDKKSNLLMTNRYQYSLQDVAEPNLYRELYDYESIPKVAFNMRHVPENMPDEIWMTDTTFRDGQQSVSPFTVEQIVHLYSLMHRLGGPKGLIRQSEFFLYTDKDKKALHACQDLGYDFPEITTWIRANEKDFELVKQAGVKETGILVSCSDYHIFKKMHLTRKQAMDKYLGIVKAALDRGIRPRCHFEDITRADFYGFVLPFAEELMYLSEESGLPIKIRACDTMGYGVHYYGAALPRSVPGIIYGLHHYARVPSEQLEWHGHNDFYKVVSNAGTAWMYGCSSVNCSLLGIGERTGNCPLEAMAIEYASLRGTLDGMDLTAVTEIAEYMEREIGIEISPRQPFVGRHFNVTRAGIHADGLLKDEEIYNIFDTAKILNRPALVAVDATSGTAGVAHWLNSYFRLKGDEVIPKTDPLVTTLRDLVAELYAQGRNTVMGDEELEIMVRTIDTERYEHLLFHKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFZ0</accession>
    <name>R7IFZ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system ATPase and permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000144">
        <property type="protein sequence ID" value="CDE49502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49502">
        <property type="protein sequence ID" value="CDE49502"/>
        <property type="gene ID" value="BN770_02030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="577" mass="63763" checksum="EEB0FE572C5229FB" modified="2013-07-24" version="1">MQDKQNFCPNKISSYFRAEWLSLTFVTLSGLFYNVGLLATPWFEGRLAQCLTDILGGYQTADAMAMLVLAYLVITLVVQGARFIKRFYVRRFANNINRRMKGILYANLVRESRTSLEKEGAGELMTKAISDVDDCVEGMRKFTTEVFDTGVVMVSYAVMLLIYDWHLALLSLLFTPISYFCAAKMKKPVQRAGAAYKKAASALSSATLDRAENAVTYRIYGCEEARAERYEGALKNYEKAAVRSNVWQSALPPLYLAASGAGVLFILWFGAKNVLGTGWRAWDIGAFTTFLSCFTKLTVKSSKVAKLFNSVQKAEVSWKRIKPLMKSPEVLDDLRIPQPADVTLDNLSFTYGDAPIFSGLSLTAHPGDIIGVTGPVACGKSTFGRVFLCEMPYGGSVRFGGKELSSFSPREISGMVGYLGHDPELSMDTIQNNVLFGSRQDVLPQLNAVVLTDEVLAMENGADTVVGSSGTRLSGGQAQRLALARTLAHPRPLMILDDPFSALDRKTEDAVFANLQAYAKDKVIFLISHRLYHFPQMQQVIFMEDGKTTVGTHDELMPSVPTYRWLYESQTGGEAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH40</accession>
    <name>R7IH40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000175">
        <property type="protein sequence ID" value="CDE50648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50648">
        <property type="protein sequence ID" value="CDE50648"/>
        <property type="gene ID" value="BN770_02464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="73" mass="8300" checksum="9CC8813D0698ED7F" modified="2013-07-24" version="1">MIRIELDVMLARRKMTLTELSKRLDIALPNLSILKNGHAKAIRMALLDALCRELDCQPGELLVWEPDDAAEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH50</accession>
    <name>R7IH50_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49912">
        <property type="protein sequence ID" value="CDE49912"/>
        <property type="gene ID" value="BN770_02184"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="304" mass="33839" checksum="F89CA91ECC7097B0" modified="2013-07-24" version="1">MKFFVTGVGGQLGHDVMNELLKRGHEGVGSDIQTAYSGIIDNSPVSKAPYIPLDITDADAVERVITAVNPDAVIHCAAWTAVDLAENTENQEKVRAINAGGTQNIANVCKKLNCKMTYISTDYVFDGQGTAPWKPDCKDYKPLNVYGQTKLEGELAVSRTLEKYFIVRIAWVFGLNGKNFIKTMLNVGKTHDTVRVVNDQIGTPTYTLDLARLLIDMNETDKYGYYHATNEGGYISWYDFTKEIYRQAGYTTQVVPVTTAEYGLSKAARPFNSRLDKSKLEEAGFAPLPTWQDALHRYLQEIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH75</accession>
    <name>R7IH75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-glucose 4 6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49937">
        <property type="protein sequence ID" value="CDE49937"/>
        <property type="gene ID" value="BN770_02198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05252">
        <property type="entry name" value="CDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013445">
        <property type="entry name" value="CDP_4_6_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02622">
        <property type="entry name" value="CDP_4_6_dhtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="354" mass="39514" checksum="1707D0979130EECC" modified="2013-07-24" version="1">MKQFDLSFYQGKKVFVTGHTGFKGSWLCKVLANAGAIVTGYSLNPPTSPSLFEIADIAQDAHSVIGDIRDYATLKAAFDAAQPEIVLHLAAQPIVRDSYKNPAYTYETNVMGTVNILECVRNSNCVKSFLNVTTDKVYLNKEWAWGYRENEELDGFDPYSNSKSCSELVTHSYKNSFFADGRVAISTARAGNVIGGGDFANDRIIPDCIRAAMKQEDIVVRNPFSTRPYQHVLEPLYAYLMIAAMQYEDGKYAGYYNVGPDDVDCFQTGALVDLFVRKWGEGMKWVNRYDGGPHEANFLKLDCAKLKTTFGWKPHWNLDTAIEKVAEWSKCYLSGGDVRACMDEEITAFLSAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHD8</accession>
    <name>R7IHD8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE50007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50007">
        <property type="protein sequence ID" value="CDE50007"/>
        <property type="gene ID" value="BN770_02231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="189" mass="20108" checksum="BACB3A21EE481726" modified="2013-07-24" version="1">MHFLIVNDDGINSPFLPILTQAVKRAGHRVTVCVPATQQSAKAHAFSIEQPILAEKREVPDADEAWAIFGTPVDSCRIGAMNLAPDADAVISGINLGYNVGMSVYVSGTVGAAREATFLHKPGIAVSAEKQTPHDTLAYLSDWAVEMAEKLVTRGAPELTVCNLNAPPIPRAELKSQVLCPAPRGGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHL7</accession>
    <name>R7IHL7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50097">
        <property type="protein sequence ID" value="CDE50097"/>
        <property type="gene ID" value="BN770_02274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="159" mass="17285" checksum="E5EEB8738196CD71" modified="2013-07-24" version="1">MNQAAIGQYIAGKRTAQGMTQEQLAQKIGVSQKSLMRWETGKRLPDADAVEALCTALGITLPELLNGKDSPQKEEMQLTHDAQMLDLLRRMQRTVYEQHILYGVLLILLGIASNALSALVGGSHVKEFFSGVLMGMSVAEMLAGVVIVAIHVIHGKCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHN0</accession>
    <name>R7IHN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000194">
        <property type="protein sequence ID" value="CDE51135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51135">
        <property type="protein sequence ID" value="CDE51135"/>
        <property type="gene ID" value="BN770_00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="140" mass="15029" checksum="23E1FC8C9132369F" modified="2013-07-24" version="1">MLNSAIACLCYSAVYALLEPFAPMFPLLISSQLIASLVGSLFVGFGAGICVRYGGAPGGDDALSMSLSRITRLPIQWVYLLSDLIVLSLSLCYIPLGKIAYSLLTVILSGQLIGIVERFDFRLMKREGLRPALVNAAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHP6</accession>
    <name>R7IHP6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51289">
        <property type="protein sequence ID" value="CDE51289"/>
        <property type="gene ID" value="BN770_00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="169"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="373" mass="41555" checksum="6D532E4D492061AB" modified="2013-07-24" version="1">MQKWVSVWGNAVSIAENRPERYAKAITLRYPIVSPFSGSGVRLTFDNYCGTEPVTLEKVTIFCGGAFHPVTFEGERRVTLPAEGNAISDTLETSVTAGEKLLVSFYLRDFTLMRSVVFTCGALSGGLYANGDETENLNISMDTSRKTQLTYFLSNVSVRTAPENRAIICYGDSITAQDWPDDLQLRCRKDGLEHTAIIRRATSGSRILREYHCLTYESYGLMGAKRFAHEVPTDGADAVIIQQGINDIIHPVGTQVNPFRPMSDLPTADELISGLKTYITQARGMGLRVYVGTLLPMGGWRTDAPFRQDLRHAYNDFIRMTELIDGCIDFDRALRDPANPDFFLPEYDSGDHLHPSKAGYQRMAAEIPAELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHQ6</accession>
    <name>R7IHQ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51299">
        <property type="protein sequence ID" value="CDE51299"/>
        <property type="gene ID" value="BN770_00366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="388" mass="41672" checksum="3A880BF84A481D50" modified="2013-07-24" version="1">MANEPKKVRQRRSMLQIPGVQTILSSLLCIVLGLLVGFVVLLLIDHGVSEKTGNLNAIDAILVIIKNFWKYGSSTAQMKYLGNTLVKTAPLLMCGLSVLFAYKVGLFNIGAAGQYVVGAGAALYCALAWNMPWYVCLLAAALAGALLACISGALKAFCNVNEVISCILLNWISLYAVNSLLSLVKDSNTPYTVKLSVGNPSALMPSLGLEKLFSNNRYVTIAIPLVIVIAVLIWVLLSKTKLGYELKATGLNKNAAKYCGMREKQNLILTMGIAGALAGIGAGFMFLSGFEEWAVAQSAVPAMGFNGIAAAFLGGLHPIGTIFASFFIQHITFGGAYVDRAIYSSQISDLISAVIIYMCGFVLFFRQVMTRLAERKAEANLRKEANLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHW1</accession>
    <name>R7IHW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M16C associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000216">
        <property type="protein sequence ID" value="CDE51364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51364">
        <property type="protein sequence ID" value="CDE51364"/>
        <property type="gene ID" value="BN770_00398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M16C_associated" evidence="1">
        <location>
            <begin position="41"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="554" mass="60571" checksum="52BC9AD959A87329" modified="2013-07-24" version="1">MQPLLSEERYQKLREMAAGADFDRLMAELLLDESTMSIIRTVPSHTQGDELRAEETERLQAIQAAWTDADKEALRVQNEKLTAWQQTPDTAEQLATLPVLSLSEISADPLLIPAAEAQCGAAKVITHDLPMNGVTIMHWYISLTDFTLDELKRLSILPELLGKLPTKRHDSLSLFQAIKRDIGKLTFQLRVMSRCAEMATPVLDVSCSVLDANVDKAAALVREILTETCFDDRARVQTLILQLSEMAKQKVISDGHRMAMYAASATMSAASAAREALNGLSACMVQKALAENFDAQYPDFLALCERVSKDSAAQPXXXRFSKDSAVQSRVTFSLSTNKALDPAAILSAYPVGMPIPDAAPYVSDLPAKCAYRIPSQISFASLGYDYRRAGKVYSGIARVMSNILSLSYLWNEVRVQGGAYGAGLNTSETGRMVTYSYRDPSPARTLGINRSMSKGLRDFVAGDERIDKYIISTVGESEPPLGSENQILVSDENLLCGITPEDLCRERAEMLSTTKDALLKWCGVLDQMAKDGGVCVVGHDGAIAACEKEDLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7II04</accession>
    <name>R7II04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000164">
        <property type="protein sequence ID" value="CDE50212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50212">
        <property type="protein sequence ID" value="CDE50212"/>
        <property type="gene ID" value="BN770_02322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00222">
        <property type="entry name" value="CollagenBindB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008454">
        <property type="entry name" value="Collagen-bd_Cna-like_B-typ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05738">
        <property type="entry name" value="Cna_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436642" evidence="3">
        <location>
            <begin position="30"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="5">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CNA-B" evidence="4">
        <location>
            <begin position="186"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="315" mass="35212" checksum="3B151D9ECC7AF124" modified="2013-07-24" version="1">MMSRKPSRLLALVLLTALCCLLLAPCALAFERVDLTHPLTFAIQADDNEDDAHLPGVTFQLYQVADMDADARFALRSPYSTLNIDINALKNAADWAAASEAMKALTASETPDFTGTTDENGRVAFAGLNPGLYLVSGTPVIIGGWAYSFQSFLTSVPTRNVDDEWQYDVLSTIKLERSPALIDLECVKVWDDDNRGTYRPVQIEIHLMQDGQHIDTVILNSENNWHHIFKDLPADHVYTLNEILGADVYYEPEYSIENGVYVITNRRTVTPTPTAPIPETGQLWWPVPILAGAGMILFVIGWILHRKWSQEHEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIB2</accession>
    <name>R7IIB2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000189">
        <property type="protein sequence ID" value="CDE51058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51058">
        <property type="protein sequence ID" value="CDE51058"/>
        <property type="gene ID" value="BN770_00284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="171"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="214"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="403" mass="44714" checksum="93E91776FE21F41E" modified="2013-07-24" version="1">MMLLTYAFRKILKRLHKRIQETDGALRVFLQERLESLVIVRTFAKEEQMAQQADALMDAHKAARMKRSNFSNLCNIGFAGAMDGAYLLGIGFCGYGILTGTMSYGNLIAIMQLVGQVQSPFANLTGYLPRYYSMLASAERLMEAEAFASDSTETVPEEQTLNFYQTELQSLQLEHVCFTYQPPVQTEGEPPAMPVVLQDVSLTVRKGEYVVFTGPSGCGKSTLLKLLMCLYPLDSGQRFLSTKTGNQPLTSAWKSLFAYVPQGNQLLSGSIRSIVAFGDEDRAQDENAIYNALKIACADDFVRRLESGLDTVLGEHGAGLSEGQMQRIAIARAVYSNHPILLLDEATSALDEATALRLLNNLRKMTDKTVILVTHRMNQADFFDKELTFSKDGICVSERKTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIF6</accession>
    <name>R7IIF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase family 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000218">
        <property type="protein sequence ID" value="CDE51405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51405">
        <property type="protein sequence ID" value="CDE51405"/>
        <property type="gene ID" value="BN770_00417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="361" mass="40343" checksum="E47F68EE28310F74" modified="2013-07-24" version="1">MRQAADKFRWSAKLAADAGIIPYKSEKGAWVTSPYDGNSWWTGGFWPGLMWQLRCATGDEQFQTEARRVEKLLTDEFRTFRCLNHDVGFMYLLSCGADAKLTGDEQAKTDTLHAASLLMGRFNPAGFIRAWNHPDQRGFAIIDCMMNLSLLWWATRETGDPRFAKVAQIHAQTTLREFLRPDGSVSHIIEFDPETGKRVKEYGGQGYCLGSQWSRGQAWGLYGFTLAHLNGGNAEYLDAAEKIAANFIRHIRPDGLTDCDFCQPKDEERIDNIAGAVAACGLLELAKITGKAEYRAAAVRLVDGLLEHCIDWTQNSCGLLTKCTASYHDDGAGRHTNITYGDYFFVEALAKLTGSDPMLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7III0</accession>
    <name>R7III0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="11" type="ORF">BN770_02363</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50397">
        <property type="protein sequence ID" value="CDE50397"/>
        <property type="gene ID" value="BN770_02363"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="262" mass="28561" checksum="9258F636D283CFDF" modified="2013-07-24" version="1">MRFTKMQGIGNDYVYVNCFEEHVENPSELAKQMSRRHYGVGSDGLILICPSDVADFEMKMYNADGSNGGMCGNGARCIGKYVYDRGLTDKTTVSLMTDSGLKILNLNVKDGKVQTVRVDMGMPELFPPKIPVDLPGEVVMGHRLNVGSATYEIHCVSMGNPHCVIFVRDPDYVDLEQIGPLLENNAIFPQRANVEFVQVVSRDHLRMRVWERGAGETLACGTGACASIVAAVMTGRADLHVVVGFLGGLLAVGWGWICSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIL9</accession>
    <name>R7IIL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51629">
        <property type="protein sequence ID" value="CDE51629"/>
        <property type="gene ID" value="BN770_00532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="127" mass="14391" checksum="007ED12EE652261E" modified="2013-07-24" version="1">MPIIPKLECRVETFREDDAVFMRIGIHQEEMLLAYYAFDTLLTGFADKIALHDHENGTDCEIVLAPAKLMTDAQISLTVNDIECIKKLLHDCIEQPYYVSWLHDDLTAATKAGEMDLAVYVVGKTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIX3</accession>
    <name>R7IIX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000239">
        <property type="protein sequence ID" value="CDE51719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51719">
        <property type="protein sequence ID" value="CDE51719"/>
        <property type="gene ID" value="BN770_00583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="346" mass="37703" checksum="4755449BF783D867" modified="2013-07-24" version="1">MNHNEFVQALKAGKVSGAYLFEGVEENIKSVTLAALRKAVLADGLAELNESVMENPSAGEIIAACETLPFASDKRLVVVRELNGTTGRSEAEERLATSIPGRPGXXRLVSYIPKVPDSCVLVIYVRGKADGRKKLYSAVKKKGGIVSFEPLGDAELNGWIVRVFQQNGKKCAPDVASLLSFTVGNDTALLRAEIEKLTALAGDRDTITENDVHAVATRSIECTVFEMVDAVVAGQRARALMLLRDMLTAGQERLGILAMLLRQYRLMQHVKIMQYEKLSRQELVKNLGIAPFAAERTMRQAQGYTGAQVRRGVEICLDTEYKVKAGQYNEDGALETAVLALLGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ92</accession>
    <name>R7IJ92_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prmA</name>
        <name evidence="3" type="ORF">BN770_00639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51829">
        <property type="protein sequence ID" value="CDE51829"/>
        <property type="gene ID" value="BN770_00639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="315" mass="34506" checksum="5FB2D4FC3D851D54" modified="2013-07-24" version="1">MDWIELTIHTTTAGADIVSEALMAEGATGTMVEDRADIPDPDKPNGYWEIIDPNLIASMPEDVLVHAWFTPDSSFADRMQALRSRCDELHHMDLGLDLGTLEISTLNVRDEDWAEVWKKFYKPFKAGRSLVVKPTWEHYDPQPGDRIIEIDPGMAFGSGTHETTSMCLELLEDAMHGGESVIDVGTGSGILAIGAAMLGAKDVLAIDIDPVAVRVAKENIEHNHLSDRVRAVEGNLLASSDGVCDLCVANIIADVICMFAQPLVDHIVPGGLFICSGIIKEREQDVVNALTAADYTILETKRKGEWVAMLSRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ94</accession>
    <name>R7IJ94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51695">
        <property type="protein sequence ID" value="CDE51695"/>
        <property type="gene ID" value="BN770_00572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="308" mass="34397" checksum="1AE8BC0B1A21449F" modified="2013-07-24" version="1">MKILVFGAGVLGCNLARNLCRAGKDVTLLARGKWAEEIKQNGLRIKNQLLPFPSVTHIPVVTELSPDSPYDVIFVVVRYTQLENLLEPLRKSRAENIVFVGNNLRTDALVAQLPEKNVMFAFSLSAGHRESSRVVSIDLKKITIGQLRTSPSNKALIDEIFAGTRYKVVYQPNMGDYLLCHAAFVTPAAFACYKTDGNLKKLKGNTAYLRKMVDANIEAYRAIRDAGHEILPDADKAFESDKYHKACLRFFKLMAATSLGKVCASDHAMRATDEMSALNRDLKQFFDANGADYPVWRALEKECGKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJK1</accession>
    <name>R7IJK1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51785">
        <property type="protein sequence ID" value="CDE51785"/>
        <property type="gene ID" value="BN770_00612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="33635" checksum="CC489B3EF2F29100" modified="2013-07-24" version="1">MGKYIVKRILQVIPMLFILSLIVFMMVRLIPGDPVDMMLGMDIPKDTKEYERERLGLNDPLYIQYFRFVGNALHGDLGTSIFSGKPVVEELAKRFPKTLTLAVGGTLFGAAVGVLLGIIAAIHRNKFADNLIMVLSLLTVSTPSFFLALILMLIFCLNLRWLPSIGMDTWQGAVLPIATLGLQAIGSIARTTRSAMLDVIHQDYIRTSRSRGVPERVITYRHAFKNALIPVLTTIGLRFGGLLAGATLVETVFSIPGIGRFVVDSVSNRDYPAIQGAVLVLAVTFVLVNTLVDLLYAAVDPRVKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJL8</accession>
    <name>R7IJL8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51979">
        <property type="protein sequence ID" value="CDE51979"/>
        <property type="gene ID" value="BN770_00731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435999" evidence="1">
        <location>
            <begin position="24"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="330" mass="37893" checksum="42F4C91B5D770959" modified="2013-07-24" version="1">MSKGKRLVLALVLLVTFCTVAIAASPKVDSILQEHDVLVPFFLPRTLFTITPQGDDVTWSISRKNGDEWEDATVSWDQSTPLQGEIGADDGQQRIWWNFKNYGDNTGHDGGVTHRLDVKVNGETVTQVDFDVTYVPELGLDYISLRDWKTEEDLKAAKYAWYNKAEVCSFGPQFKEACDELTDEWYRFSVVDLSQQGTQVFDMIANDTWHLGYVTVTVDGDWAQVDYFCSEDLDPDSQWDQVHVYREFFTFFRSTEEVHRLTPRRIESPFAFGKPFRISDYFGDDRVALLYVNNLMSFSTANPYVTRFGMNKPENQDTLNAMKALMNHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJQ2</accession>
    <name>R7IJQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50807">
        <property type="protein sequence ID" value="CDE50807"/>
        <property type="gene ID" value="BN770_00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="136" mass="15053" checksum="2C2A4841A923C5AB" modified="2013-07-24" version="1">MLKCFNLETKPNDVINLTDDIKQFVAESGIQSGECIVFNPHTTAGLTITSFWDPAGFEDLQDEICRLIPTRIDFKHQHDTPTDAAGHVKCSLLGVSIPLIIDGGKLVLGGSQGIFFLEFDGPRKRKYYVKLISDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJR2</accession>
    <name>R7IJR2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC-type DNA-binding domain-containing proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50822">
        <property type="protein sequence ID" value="CDE50822"/>
        <property type="gene ID" value="BN770_00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="184"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="292" mass="32934" checksum="DCA6B00183AC99B9" modified="2013-07-24" version="1">MLTYTMDVLPESIWLRTTPGASAMGQPYVCTEAGQYLAQEHFSTARTHKESYLLFYTLRGAGLIEQGDDRVLLRAGQALLMDCRKPQRYATAPGQHCWHHDWVHLDGAGVAAMAEWLIPEGKLTPITLTDQKVEEQFKTIFAELESGTVDSMLQVSLALHQLLTLCAQGLLNQEQTESNQQVIQQAAQTIREKYNQPLSLNDLLRQAHMSRSYFLRLFRRYMGTTPYNYLISTRITQAKALLALTDRSVSEIGREVGFGDASNFSARFSAAVGQSPMQYRRSALHQAEKEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK54</accession>
    <name>R7IK54_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51688">
        <property type="protein sequence ID" value="CDE51688"/>
        <property type="gene ID" value="BN770_00568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="199" mass="22212" checksum="714A79D46A76BDEE" modified="2013-07-24" version="1">MRLTTLDEASIQAIGHAFGYYDYGKETGMGAACSSPDKTALYICGFVRAMLAAGLLYTTSERGEAFIAYRLPGERVKLTAFLPLLKGVFQAMTFRELCRFARLMKRAGASLNDRYDKEKKPHIYVGLVCVTEKYQGQGYMRKVLEMAFADGNRLQVPVILETDAKSKCDKYVHLGMELAGTRDAGELGTLYDLIKYPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK69</accession>
    <name>R7IK69_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000255">
        <property type="protein sequence ID" value="CDE52020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52020">
        <property type="protein sequence ID" value="CDE52020"/>
        <property type="gene ID" value="BN770_00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="5">
        <location>
            <begin position="210"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE52020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="318" mass="34150" checksum="CA3EEED39BD5C33C" modified="2013-07-24" version="1">MEFLEKLSLAGLVPVIAVNDADDAVPLCKALSDGGLPVAEITFRTAAAEEAIRRVHEAMPDVLLCAGTVLTTEQVDRAVNAGAAAIVSPGLSPDVVKYCVEKDIPVCPGTANPSDVQIAIQYGLKAVKLFPAEAVGGLKLIKSMAPVYPDMKFMPTGGINENNMLDYLAFDKILCCGGSWMVPKDAVAAKDWQRITDLTRSAVDKMLGFEVRHIGLNCPDAESSMETAKKISALMGWPIKEGNSSNFVGTGYELMKKQGRGTNGHIAIGTNSVPRAKWHLEQRGFKFIEDSAVVKNGKLIAIYLEDEIGGFAFHLVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK89</accession>
    <name>R7IK89_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NusG_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51881">
        <property type="protein sequence ID" value="CDE51881"/>
        <property type="gene ID" value="BN770_00668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="NusG_II" evidence="2">
        <location>
            <begin position="104"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="210" mass="22717" checksum="B23DDF976EF84CFC" modified="2013-07-24" version="1">MKKETNPKAKRNGLWCNVLIVAALLLIVAVLMVVLRRNAPASVDANAPLLPLTATDALTEAPTELATSTPEAAATPEITAAPEAAAAPEVTDVPEATATPDLSQVKAFLVVTVGDKTYQPIPLTEEGYYRLRHGDCINIVHVTPTSIDMHEANCDNQDCVEQGEVTLENKDTRILGNMIICLPNQVTLQLYSRDELMDWLTTVQEDAANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKD4</accession>
    <name>R7IKD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000241">
        <property type="protein sequence ID" value="CDE51738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51738">
        <property type="protein sequence ID" value="CDE51738"/>
        <property type="gene ID" value="BN770_00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1068" mass="115865" checksum="CA0D1DB4AE711DB7" modified="2013-07-24" version="1">MSKLLFLPDRNGREKESEGAGLVRLSADTSEMAALAKRMVIRQETDEITPDAAYQGAMALALLLDSWQGTDVRLAVRTIDAQKSRFAAWVMAARPMEQRNQPIRLLMLVKDQQEALLGLVDAENGLTLAAQIGDIWDMLPERATWVNREDKCFGSPLPLLNEADCDLLLRRLHRMNLPGDRAKSFRAALNQRLTQEREMLSHSEEETLARLAIRAQAALGMMKVPSFAVLEENSLTDTENPLMQCFTSETVGASEALKRQQVLLWHGKAFGRSSKVLGWTDANWPDEAETLNGVEQEIALMADGSVWWNKKLADALNAYLRERSDKALLPAAREYLTLVKGQAEQNARQVQGTVTLQFPWRADSGAVQSLLQEALGDGWQEAAKQPFSQRLTCLTGVQLGDQALRTCCILENATMLPPLSMEMAKTVAENPNALALDAFRYQVEEDGSVTASYLLRARGEVRFVRTYAPDEQLYLENPPMVAVYPCAPMVFWHQYQVLVKGGDAKVYALSDGQWQGVENRENWTALLTAQYPSCLTLEKDGESLGALPNILDKEPDAGGNQPAIASIDLGTAVTAVTLTIGGREIPATHRPLLRMLLTLSDTPMDDMMTSLTMAANLIPTAVVLTGAGDVPGRDGYVYRPADMAALAAKEENRLLTSFKWRSDAAGVRARTLLIQQLMLDTALSAVLQGAGSLSWRIAVEDDMGDGGRRAVLDAVESGAAAATIASGLAPVPGTERVSWTPETAALGAYLRGEGGIHGGCAALDIGAGSIRAAIYLQNRTTPERSANIPYGTQLTLYETYANHPERIEYDFGGCSMGSLSLAKDALTAAFSVASDTQAHVGKTCMMLDLLLTENAAPLAMHLNARANAGQVTFLQSVVAEYLAGALFVAGLLTANVQADSMQNHYLPASLPVALTGGGALLVNLLPSGMVGNLNQFVSVATGRTYAAGNIQVQLMREGKWALSRGLSALKTLEIPPETPDLTRHQSFSEQMLHLMQTLCTVCPAHMWLLHPGLFDSMGRMTPAGIDTVRRVSARTYGEDDDMPASVMQFLSELRRSPIVADQLTPPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKE4</accession>
    <name>R7IKE4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsL</name>
        <name evidence="8" type="ORF">BN770_00021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51092">
        <property type="protein sequence ID" value="CDE51092"/>
        <property type="gene ID" value="BN770_00021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="124" mass="13694" checksum="6244A9C66CE54CAB" modified="2013-07-24" version="1">MPTINQLVRKGREKTTNKSTAPILQGCPQKRGVCLSVKTMTPKKPNSALRKIARIRLTNSIEGTCYIPGIGHNLQEHSVVLIRGGRVRDLPGVRYHIIRGALDTAGVAKRMQARSLYGAKRPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKE6</accession>
    <name>R7IKE6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3048_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000242">
        <property type="protein sequence ID" value="CDE51753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51753">
        <property type="protein sequence ID" value="CDE51753"/>
        <property type="gene ID" value="BN770_00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3048_C" evidence="1">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="172" mass="19602" checksum="FA00C2CABDB7A143" modified="2013-07-24" version="1">MSRLVPEDHAAPNHAFRFTDDAPDGDSATRVYINWGDSAKLYNSRLVYRKEWNGYLRYMGTSKTNWYADRDSDDSAIAFQNVIVQFTRVDYNHNNKNEPIMYVIGENGEAAEGNADFFLGGKHISGYWKRDGMTSRTVYYDASGEEIALLRGRTLIVIFPDDAASKRSVSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKF0</accession>
    <name>R7IKF0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000243">
        <property type="protein sequence ID" value="CDE51758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51758">
        <property type="protein sequence ID" value="CDE51758"/>
        <property type="gene ID" value="BN770_00598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="107" mass="11896" checksum="B1766C0D94F3EFE2" modified="2013-07-24" version="1">MTNNDESSKLEEMGEPLIELTAPDGTVMRFRFGAVIPLDDIEYAVLLEMEDNPDGEEQVLVTRIEPTDDGGMTFVVEENPQKVEQVFNSYVNLRTQEGLTGLTDAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKJ7</accession>
    <name>R7IKJ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplA</name>
        <name evidence="10" type="ORF">BN770_00300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000195">
        <property type="protein sequence ID" value="CDE51142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51142">
        <property type="protein sequence ID" value="CDE51142"/>
        <property type="gene ID" value="BN770_00300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="229" mass="24787" checksum="9825FAE56975623F" modified="2013-07-24" version="1">MKHGKKYQDSVKLIDHLNQYDPDQAAQLVVSTGKAKFDETVEVSIRLGVDPRHADQQVRGAVVLPHGTGRSIRVLVIAKGAKADEARAAGADYVGDQDMITKIQTENWFDFDVCVATPDMMGLVGRIGRVLGPKGLMPNPKSGTVTMDVTKAITEIKAGKVEYRLDKTAIIHCPVGKVSFGAQKIQENLTALMEAINKAKPAAAKGVYVRSLYISSTMGPSVRVNPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKK5</accession>
    <name>R7IKK5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000255">
        <property type="protein sequence ID" value="CDE52021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52021">
        <property type="protein sequence ID" value="CDE52021"/>
        <property type="gene ID" value="BN770_00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE52021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="350" mass="39234" checksum="63A00AC27B4568DE" modified="2013-07-24" version="1">MSQVISFKCPSCGGYLVFDPVKQRFQCPYCGGSFAENELKEQSEQRQQAAEQARSAEPNSELRSYHCQMCGAEIVTDATTAATRCYYCHSPVVLNDRLTDEFRPDGVIPFKLDKKAAEAEFKSFISKKRFVQPDFFSQAQMEDFSGVYYPYWACDISGEGSFDGEGTNVSIRNGAKETVTITRIFAVHREGRLTFRQMIRKALTKADGKLSDGIHPYQMEDVKPYESGYLSGFLAEKRDIEQDAAKQSMVTEAKGYAERMFTSVENPYNTLTGHAKFEPDSVKTKYLLLPAWVLTYKHRADGEPYYYMMNGQTGRICGKLPINKGKLYAVGALIGGVVFGLLCLGGAILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL45</accession>
    <name>R7IL45_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tripeptide aminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of the N-terminal residue from a tripeptide.</text>
            <dbReference type="EC" id="3.4.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.4" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000213">
        <property type="protein sequence ID" value="CDE51332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51332">
        <property type="protein sequence ID" value="CDE51332"/>
        <property type="gene ID" value="BN770_00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="10">
        <location>
            <begin position="201"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="399" mass="43463" checksum="2F8E0655FD3DDF1C" modified="2013-07-24" version="1">MSNVKENFLRYVQIETTSSETSGTCPSTPNQWVLAKMLVDELHAMGIENARVDDHCYVYATIPAKGNHPAKVGLISHMDTSDGVKGPTHPVIIEHYDGSAITLKNGVVIDGFPFLKDLQGQELIVTSGDSVLGADDKAGVAEIMALCKRLTAPDAPEHCTVCIGFTPDEEIGSGADHFDVAGFGADYAYTVDGGALGELEYENFNAASCAIKVHGVNIHPGSAKNQMRNALLMAIEWNSMLPPAETPAHTCGYEGFYHLMHMEGDEELATLQYIIRDHDAQKFDARKATVQQITDYLNQKWGAGTFECVIRDSYRNMREIMEQHMDVVEKAKAAFEANGVTPVISPIRGGTDGARLSYMGLPCPNLSTGGYNFHGRKEMITVEAMEAMVNVLESIVRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I2M9</accession>
    <name>R7I2M9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_Tnp_ISL3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000003">
        <property type="protein sequence ID" value="CDE46164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46164">
        <property type="protein sequence ID" value="CDE46164"/>
        <property type="gene ID" value="BN770_00760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032877">
        <property type="entry name" value="Transposase_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13542">
        <property type="entry name" value="HTH_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_ISL3" evidence="1">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="147" mass="17155" checksum="890AB7865B3962B2" modified="2013-07-24" version="1">MFESRQRTADVACPYCRGKVEICELANKQLKDIPVWQGISQELCFLCHRYRCTKCGRKHTEEIPLQHPGTRITERAATWIQTLLLNQMTIRGVQQITGIHWETIRRIHVQLMTQMLQAHRKELKARKYQRALTSFCCEESGTLNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3I4</accession>
    <name>R7I3I4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46464">
        <property type="protein sequence ID" value="CDE46464"/>
        <property type="gene ID" value="BN770_00877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="955" mass="105251" checksum="46BBFEB7089EA7E9" modified="2013-07-24" version="1">MKIDLNSPVEVWRIDAPNTGFPSCELTLFNLSGQQVVSVEVTLTLLDPDGQEITRITHRAHGLTGAPMRTFSMTVPVEEPANVGGCEAIIEKVWYDNSSIWRRGKEPLTEYTPNNLHRSTALSELREVAGNMAAGYPEMQGDLWLCVCGRPNPVSVATCARCGRDKRDVFTHFSKEAVDAVIAAREKATDDQNRVAVEETSKLQAQREQEVTKRRRHRRVARKVPSRRRHRRVVAGAVALIVLILGGGYGIMFHLLPQMKYNDAQTALTNGEYTAAAEKFAEISSYKDAADMVEESNYRHAKALLDSDNVTAEDIAQARTLLDTLTDQTRTDDLRKSADYQEGLLLLNEGKLDDAEKLFTALGDYENSRTQLQEIAYRRLSAEMETASDYDAIREGLTALNGYQDSAALIEKTWYLEAKSLLEGDNPDPVSAIACLEEIPDYEGAAELARKAHYAYGKQLQAAGETATAAEQFYLAKGYEDADEQANVSYYAPAVKALDAGKFKEAARLLQNIRDYSDADDLWKKAIYQQALVEMKALDFDAATALLNQLPADYNDVATLLKDCVYQPAQIAYSRGEYEAAIVGFTAVSDYSEAADMIRLCNYDWAAKKAQDGDYDGAIALYEALGDYKDSAQKISEVRTMKAQALASTGALDNLQSAAVIYAELGDEANLAATQYQQAALLLQNQQYTDAREIFAALGTYKDAATQLKACDYAIALQKKDAGQLDEAAALLEGISGYSDADEQLKIVRYAQGEKAVADSLSLAAAQFFTQAGDYSDAADRAAAQYAAYYGPIADSARAQYNQQEYTAVADLLMNLNMENLPADYADLRDIFRESCYQAGESYYAAGQVYQAYPYYQEISDERRVKERLKEACYLVLGTWQDTAGNAYTFNLDGTCTLAGESLYFAVDGLTIRTGTSADALTATHQLTGISATSAWLFDQRNGANTRIRLTKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3S6</accession>
    <name>R7I3S6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Chorismate synthase</fullName>
            <shortName evidence="10">CS</shortName>
            <ecNumber evidence="4 10">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroC</name>
        <name evidence="11" type="ORF">BN770_00805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="10">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 10"/>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46255">
        <property type="protein sequence ID" value="CDE46255"/>
        <property type="gene ID" value="BN770_00805"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="366" mass="38974" checksum="FDC31CFBF10E398D" modified="2013-07-24" version="1">MSSAFGQYLKLSIFGQSHGEALGVTLDGFPAGMTIDMEQLLAEMARRAPGQSLMTTARKEPDAPEFLSGVLNGRTTGQPICAIIRNTNQRSKDYGDGVDLVRPGHADYTGHVRYFGFEDWRGGGSFSGRLTAGIVLAGTLCSQYLVHQGVKIACHIQQLGNVRDASFLAADAAADYAFLKGMHLPVLTAGLNQQMEETVLAARDKQDSVGGVLECMVTGLPAGLGAPFFDSVESVLSHLLFAIPAVKGVEFGEGFGFASMRGSQANDPFRMENGEVTTESNHSGGINGGITNGMPVIFRCAVRPTPSIGQKQRTVSLRTGENADLEIHGRHDPCILPRAVPVVEAMAAIGMMELWKERAACLDGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I402</accession>
    <name>R7I402_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-trcl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000021">
        <property type="protein sequence ID" value="CDE46624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46624">
        <property type="protein sequence ID" value="CDE46624"/>
        <property type="gene ID" value="BN770_00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026363">
        <property type="entry name" value="CxxC-x17-CxxC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04272">
        <property type="entry name" value="cxxc_cxxc_Mbark"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10461" checksum="EFCD3FE46A82B6E8" modified="2013-07-24" version="1">MYTDKTLVCKDCGNEFVFTAGEQEFYAEKGFQNEPTRCKACRQARKASRPAAGGTREMFDAVCAECGKPTKVPFQPREDRPVYCSECYAARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I404</accession>
    <name>R7I404_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46206">
        <property type="protein sequence ID" value="CDE46206"/>
        <property type="gene ID" value="BN770_00781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014225">
        <property type="entry name" value="Spore_II_D_firmicutes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02870">
        <property type="entry name" value="spore_II_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435367" evidence="1">
        <location>
            <begin position="27"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="2">
        <location>
            <begin position="41"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="321" mass="33898" checksum="1D3569893A3482A8" modified="2013-07-24" version="1">MKQKQLLSFLVCILMLSSCAAPTDSALDSGLTLRVYFADAEEIRLLPLEDYVFGALAAEMPANYAPEALKCQAVAARTRAVAQSHVFGGNGCVRHPDCDICTDSACCQAYQTDAQLQARWGSEYVVLRARIDRAVRATDGLLLTSGGLPIEVLYHACSGGKTEDAAAVFASAKPYLVSVDSPGEEGYAGFRADTSFSCEEAADLLLRAFPGCGVTADTLPSAIRLQSTTASGRVATLLVGSQTVRGADFRKALSLRSTYFTWEANGGSIVFHTVGYGHGVGLSQAGAQAMAADGADFAEILVHYYPGTQLTRMDKTGFSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I459</accession>
    <name>R7I459_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000016">
        <property type="protein sequence ID" value="CDE46435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46435">
        <property type="protein sequence ID" value="CDE46435"/>
        <property type="gene ID" value="BN770_00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435372" evidence="1">
        <location>
            <begin position="25"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="586" mass="61935" checksum="D3CDC16662931BF3" modified="2013-07-24" version="1">MKRFLSLVLAMLIAITMLIIPASAENYATAVVKGGWLRLRAEASASSETISAYFTGTQVTIIGTSGEWYYVLTPDGHYGFMNSNYLTVTGSSSGSTTTESTAYIYAANGKPVRMRSGPSTDYGVVASYSVGTQVKVLISGADWSKIRVGTRTGYIMSKFLSVTNITPSTPSSSYTAYVTASNGKPVRMRTGAGTNYSVISTYSVGTQVTVLEYGKTWCRIRVNGYTGYMMTKFLTTTQPTIISSAALNKNTVWPGETLTVTTNPANISVSYEWLNDVGARLGTGSTYTVKTSDTGRRIRVRVTGKNGTTGSVVSGWAAVQGNGTVGTVYQLKALTLNTTNAVVGTTLTATIAPSGATANIYWYLDNGTYLGYGSSYTVQPNALGRRIFAYAEGTNSTTGTATSAYTDTVTAGATPSIVLSSVTLYNYSPTVGTVLTATIAPANATATILWYRDDNVYLGTGMAYTVTATDVGHRIYAWAQGTGSTSGNVTSPYTQQVTAGTSYRIDSVTLNNLNPIVGQTLVASVAPYGATATITWYRDDSKILSYGATYTVQADDIGYSIYVWAEGTGNTTGSATSKITSEVKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I520</accession>
    <name>R7I520_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46586">
        <property type="protein sequence ID" value="CDE46586"/>
        <property type="gene ID" value="BN770_00953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436169" evidence="1">
        <location>
            <begin position="24"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="402" mass="44411" checksum="3F2896E7F638E99E" modified="2013-07-24" version="1">MKKLVSMLLALAMVLTLAGGALAETKDYSGYTIRIYSNSNSTERVNWLLNAAKEAGFSISIDDNSVISGDNAAIQKANESKDGDIIFGLNETRWSQLVNGTYENLKVMDWTPSWADEVGKYVYPGKAYGLVVQNVLMLYRNDDKGTNGEALHFQHWSDIVDCGYHWYRQGKVGGTTNSNINSAMLYAFTDPTSPAGGISVDGWKMLWKYCANGSYTGDSYGFDPLNRGDVQVSTFYSSSLYGKIDSAADSSSAPLTGTTTPENWGVVDIDDGTYYIAEYIGILDRADRTPEQTEAVKAFAEWFGSAETQTEWSDEFDSFPCNEVAVKNVYGDEIPAIYQLKNCALEKVEGTDMTYAEYVAAHSKEWTNIMTNLGFYWADASQAPAEPDWDNVNWAVMTQAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5C0</accession>
    <name>R7I5C0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ORF">BN770_00870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46453">
        <property type="protein sequence ID" value="CDE46453"/>
        <property type="gene ID" value="BN770_00870"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="148" mass="16107" checksum="FC8BF94D88CBB1C9" modified="2013-07-24" version="1">MSEPKKILILNGPNINLTGLREKAVYGAKTYDDLLALCRAEAEKLGVEVRCVQSNHEGDLIDALQKAYFDGFCGAVFNPGGYTHTSVALHDAIASVPMPVIECHMSNVHAREEFRHKSVTASACRGQIVGFGFYGYVMGMRALLEADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5J5</accession>
    <name>R7I5J5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47149">
        <property type="protein sequence ID" value="CDE47149"/>
        <property type="gene ID" value="BN770_00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="426" mass="44422" checksum="C4752228DCFF9044" modified="2013-07-24" version="1">MTNQKLSPAKFTLLGFQHMFAMFGATVLVPTLTGLSVSATLLFAGLGTLLFHLITGGKVPAFLGSSFAFLGGYAAVKAMPQFADGTMNWIPYAGVGVAVAGLIYVVVAGLFKIFGAQKVMRFFPPIVTGPIIICIGMILANSAINNCSNNWLIAILAVVIVVAFNIWGKGMFKIIPILLGVVGSYAVAAVTGQVDFTPVKEAAWLGLPFQWKDTAFSLFGGCDGTLLLNCIITVAPIALATMMEHIGDMSAISSTVGKNFIEDPGLHRSLLGDGLATTMAALFGAPANTTYGENTGVLALTRVYNPAVVRMAAVLAVVFSFCPKFAELIHCMPAATIGGVSLILYGMISAVGVRNVVENQVDFAKSRNVIIAAVIMSLALGINFSNAGAIVFTVGQVTISLSGLAVGCLVCALLYARVARAWSASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5M2</accession>
    <name>R7I5M2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative alpha-dextrin endo-1 6-alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46558">
        <property type="protein sequence ID" value="CDE46558"/>
        <property type="gene ID" value="BN770_00933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="255" mass="29339" checksum="2E4E07D471E2215F" modified="2013-07-24" version="1">MIEKWTTPIPKLSGREGRTVYVYVPDEAQENPEARYPVLYMFDGHNVFFDSDATYGKCWGMKEYLESTNTPLIVVAVDCNHSPNNGRLSEYSPFTFEDPKLGYIRGRGRTTMDWFAHTLKGMIDEKYPTLPGRETTWIAGSSMGGLMSLYAVTAFNDVYSRAACLSPSIWFATRSLDRLIRDAQFAPDTVIYMDYGSREMAHHDNMRKQYAAVTSRLLEKQVLLTSRIVPNGDHCEACWEEQIPFFMHVLFYNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5N9</accession>
    <name>R7I5N9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylglycerophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BN770_00940</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46573">
        <property type="protein sequence ID" value="CDE46573"/>
        <property type="gene ID" value="BN770_00940"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDE46573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="193" mass="21137" checksum="08EA8C12A67C5589" modified="2013-07-24" version="1">MGSFSSKYLKDIWNLPNILTMLRLVLIPVFAGLFLAGYEKWALAVFIIASITDYLDGYLARKNNQITAFGKLMDPLADKLMVCTALLGQGLSGVFPWPAILIVMTKEVVMIIGGIYMLQNGIVVYSNILGKAAQFSFIAALILSFWHKEFVAASLPLDRIILWIAVALALVALVDYALDAAKKLKAHKAGKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5T0</accession>
    <name>R7I5T0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47005">
        <property type="protein sequence ID" value="CDE47005"/>
        <property type="gene ID" value="BN770_01101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447540" evidence="2">
        <location>
            <begin position="30"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="392" mass="43637" checksum="58D7A267F08D5BE6" modified="2013-07-24" version="1">MRNARALQRIAIILAVLFALSLLPVVAVAFYNHPRADDYTYGAVLRKVIDAGQGLPEAVAAIAAYVRSTYARWQGSFSAVMLFTLQPGVFSDNAYWLTTALTLLPLLLGTGMLLRQLGKMLHAPRATAVLIFLALMTLSIQLVPDLNQTFYWFNGGCYYTFYYALSLMLLTGTLRICTDGKCRAGRTVLCMALAFFIGGGNYTTILVTLILLMLLLLALLVRKNPAWRQILLVMTALLIAFAINAAAPGNRVRAATIPRSMDAVPAILYSFDRAWVRVSGWFGWPQGIAIALFALLMWDFVGQCGLKFRFPLLKSALAYAIFSAQMTPSLFAMANVGPGRQIDIYYYAYGWLLLCWTFLWIGWLRNSRIGTKIDAGLSYLTRHSPATRRFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5U0</accession>
    <name>R7I5U0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tagatose-6-phosphate kinase</fullName>
            <ecNumber evidence="4">2.7.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12420"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58694"/>
            <dbReference type="ChEBI" id="CHEBI:58695"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.144"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbohydrate kinase PfkB family. LacC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.144" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47015">
        <property type="protein sequence ID" value="CDE47015"/>
        <property type="gene ID" value="BN770_01109"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00704">
        <property type="reaction ID" value="UER00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001059">
        <property type="term" value="P:D-tagatose 6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005988">
        <property type="term" value="P:lactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0423">Lactose metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="11"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="307" mass="32308" checksum="C8C824C80BAB8680" modified="2013-07-24" version="1">MLACVCLNPSFDRTVSLRSFTVGDMNRVLSARQDVGGKGINVAITARRLGIASCVLGCAGKNGIDAVRRKLDGEQVTHVFLPVDGDVRTNMKIVPQDGTGVTELNEPGAPVNAANQRAFSDLLAEKTVAGQYVVLTGSLPPECLPEYYRDLMLLLPERLFVLDVSGAALMAGLAARPFLVKPNRSELQAAMNRPLPTMADVHQAALELLEMGAQNVLVSLGSEGALWVSERGAMVAPAIPVRVQSTVGAGDAMVGGVMTGLEKTGDVRRALAYGAAAGCASVMTEGTQLIRPDDFAALLPQVQIQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I605</accession>
    <name>R7I605_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47085">
        <property type="protein sequence ID" value="CDE47085"/>
        <property type="gene ID" value="BN770_01141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="350" mass="37674" checksum="357824CE7A45E3F3" modified="2013-07-24" version="1">MQRIQKRRAGQRQTQNALIGLLSAVSMTRIGLTQLLPLCGSAAWWLSAACMLPGLCVYGALRLLLRHTHTRTLTDCARKLLGNFGIILIMLTLTLPLLLDGIASLTALITFFTEGIGARGSQFTLTLLTTSVMLIALNRDGLPRGVYLLRHVLLVAAGIIAINALLDAHPDGIVPLLGEGVPPLLSGIRSTWGMSWVLLLLLEFPAEEGARRTPAMLAGLLPCPAILLLLSLAIPPELTVPGRSLASGLVLPTLFLQPAVRTLAQCLLMMTLFLSIAGSAQLAARFLTSSCQKPKKWVPYVLIGLLMLTQLLDISSLWQILTALTAWSLVPAVLLLLLLTIARLCRRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I610</accession>
    <name>R7I610_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0210 protein BN770_01146</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0210 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47090">
        <property type="protein sequence ID" value="CDE47090"/>
        <property type="gene ID" value="BN770_01146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08025">
        <property type="entry name" value="RNR_PFL_like_DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01221">
        <property type="entry name" value="UPF0210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="448" mass="46573" checksum="DB12E390B2C25EDA" modified="2013-07-24" version="1">MIETGEILQTMAMIQEQNFDIRTITLGINLLDCSHPSPEACAQRVYDKICRVAKDLVRTGEAIERELGIPIVNKRISVTPVSLICQGDPRPIAKALDRAAKEMGVNFLGGYSALMHKGATLADERLLVSIPEVLSTTERLCSSVNVGSTRAGINMNAVREMGEIIKKTAALTADTDGLGCAKLVVFCNAVEDNPFMAGAFCGVGEPECAINVGVSGPGVVKRALESVKGQPFDVVAETIKKTAFKITRVGQLVAQEASQRLNIPFGIVDLSLAPTPARGDSVAHVLTEMGLEMAGAPGTTAALALLNDAVKKGGVMASNHVGGLSGAFIPVSEDIGMIEAASAGALTLEKLEAMTCVCSVGLDMIAIPGDTSAAAISGIIADEAAIGMVNNKTTAVRVIPAVGKKAGDTVEFGGLLGFAPVMPVNPYGNEEFVARGGRIPAPLHSLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I686</accession>
    <name>R7I686_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47006">
        <property type="protein sequence ID" value="CDE47006"/>
        <property type="gene ID" value="BN770_01102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="97" mass="10394" checksum="265CE67701871BB7" modified="2013-07-24" version="1">MLTLPSAHPTAGASPTSVAAAKALISGEAQTYHQQYTEILQTLRQPGEICEIPDIAVCPAFLNPLGLADEGQSGYWVNQALANYFGHQKVVKTEEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6G9</accession>
    <name>R7I6G9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Germination protein Ger(X)C family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47086">
        <property type="protein sequence ID" value="CDE47086"/>
        <property type="gene ID" value="BN770_01142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435521" evidence="4">
        <location>
            <begin position="26"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="329" mass="35778" checksum="3DBC9F2A6221EB64" modified="2013-07-24" version="1">MKRALCLLMICLFCTGCSALPPEERAFCVVLLIDGGAQECTVRVRIPTYQQNGGYQTLSATGATLTDALRTLESAAPMRLHWGQLRLIVLSRAWAAEIPIVRTLSDLSGVENLRLHASVAVTGEDTAALAEKLVPENGTRLSKSIDVMVQARHEQGVIPTCAASVLLRFGSRQSPVLCGAESTAEGLLLSGAWLTDADGLVRDFLTPEETQILLLMQGELTRTQLLLPEHAIHLTEASTSIRLMEDTAVCRVNLRYDRADLTPQGVSAETAQACLDVLNRLQAAGCDALGLGRKAIWSAWSMSDWRDSDFPARLQNLRWTVEVRSEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6H1</accession>
    <name>R7I6H1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000002">
        <property type="protein sequence ID" value="CDE46137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46137">
        <property type="protein sequence ID" value="CDE46137"/>
        <property type="gene ID" value="BN770_00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="81"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="352" mass="36823" checksum="5422B2BDEF3F6FAF" modified="2013-07-24" version="1">MDFLKTLLAYVALTVAFSVQEGPLPQDVPTPTPLPPNVTASPIPNAPAATDVPTATPTASPIPEPTITPNMGYRTVQWQDRGSGVLKVQKKLIELGYLAEGEDDGAYGSKTTAAVRRFQKANGLSVDGIAGQATQTRLFEDPNVVPYSPPTVPPTATPTPAPETPAPSAAPTASPADDLPLPGASGDFPVDTVTTEAPVYTPDGLTLLPNGSIFLGSGGNGQALTMTVTQDGVGYTRRPSLWVNTVGSPVMSLRELAACIDDWQLDVSESGVWVLSAAGYTVVIRETDSGLSVMVDGSAIAMESGAVRLDNGEVYISDMFLRTALRATTIYDSDEQSLILFVRNKSVSTSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6T0</accession>
    <name>R7I6T0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47340">
        <property type="protein sequence ID" value="CDE47340"/>
        <property type="gene ID" value="BN770_01215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="394" mass="43637" checksum="E2B9F62C7319486B" modified="2013-07-24" version="1">MNYDRYINQAIAAVPPSGIRRFFDIAATMKDAISLGVGEPDFVTPYHIRNAAINSIIDGGTQYTGNRGLPELCREISEYLSERFHTDYDPKTEIMVTVGASEAIDIALRALVGPGDEVLVPQPSYVSYSPSVIFAGGTPVGVETTADTEFRLTPEALRAAITPRTKCLILPYPNNPTGGIMEKADLEKIAQVVRETGILVISDEIYGELTYGDRTHISFASLPDMWQYTITLNGFSKAFAMTGWRVGYACGPKEILSVMLKIHQYSILCAPRMGQVAALEALQAGRANDYEDVRRMRDSYDRRRRLMVDSFRKMGLDCFEPLGAFYVFPSIKKTGLDSETFCERLLNEYKIATVPGTAFGECGEGHIRCSYATGVEKLNIALERMSEFVDKCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I733</accession>
    <name>R7I733_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47266">
        <property type="protein sequence ID" value="CDE47266"/>
        <property type="gene ID" value="BN770_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="275" mass="31126" checksum="89C156864D9A615F" modified="2013-07-24" version="1">MKKFVSTLLIVCCLLYYIPVLADETTMTGGELLAMHFIKEFYAEDKGDGEAYFVTFDAANKHFIVRGHYPLLESLIADDPENYQQMVDKLETLFASIDDLIRVCLEEPDAYYMTLSFGLSRLSLESSTGKYLCFSSKGGTVHRVNDEFVTTPQVAFYVAYEDSDPDDVHALLDFYAEKGAEFSVVEYLPGEDKQNIGYIIKISGEYCDAFEKNYAGKSQNFVNVPYVYLQNAREIAKQLDIGFISILFCNFDGKAFGRFDFRHSSSSGSYFAIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7W7</accession>
    <name>R7I7W7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47596">
        <property type="protein sequence ID" value="CDE47596"/>
        <property type="gene ID" value="BN770_01306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="82"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="297" mass="32119" checksum="46A2B19CCF469CC1" modified="2013-07-24" version="1">MMTVPAYRAHPIRNFFRNESNRWRRHPASALLRLLCRLSVLITIFALLAIVIDLLVKGLPHLTPELFSLKYTTENQSMLPAIINTLLIALVALLVAIPIGVGGAIYLAEYAKRNSPLVRTIRLTAETLQGIPSIIYGLFGMVFFTALRINLTLLSGALTLSLMVLPLILRTTEEALLSIPDSYREGSFGLGAGKLRTVIKIVLPPAMPGILSGVVLAIGRIVGETAALLFTAGTVADMPKHFLLSSGRTLAVHMYQLSLEGLHYDQAYATGVVLLLLVLGLNSLSSLISRKIGGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I829</accession>
    <name>R7I829_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BN770_00984</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46672">
        <property type="protein sequence ID" value="CDE46672"/>
        <property type="gene ID" value="BN770_00984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="12">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="13">
        <location>
            <begin position="129"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="14">
        <location>
            <begin position="248"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE46672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="371" mass="40648" checksum="04B4DD4129809401" modified="2013-07-24" version="1">MQFTTNVQLLLDGLNTVTRALSARPTKQILEGVHLSAVGEHVKLTCSDGNLSIEMSILADVKEEGTAVLPGRLFTELSRKLPGGEVTIRVGENHAASIRCLSSKSNLAGMNPTDYPEMARVAEGTTVRIPQDKLKEMISRVVFAIATEDNRQILTGCLLEVEPTEARLVALDGFRLAIQKAVMPFELPGGKENVRVVIPGRVLNEMSKVLGDTDEYCTLVFDQSRMTASFGTTTLSTVLLTGEYIDYRKILPASFRTTALADRVGVQNAIDRASLMAREGKNNLIRMSFSGDTLAISSNAELGDVLEELETELTGDPIEIAFNAKYITDVIRNITDEKLCMRFNSNVSPCVIAPQEGEDYLYLILPVRVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I880</accession>
    <name>R7I880_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000064">
        <property type="protein sequence ID" value="CDE47795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47795">
        <property type="protein sequence ID" value="CDE47795"/>
        <property type="gene ID" value="BN770_01360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="14"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="362" mass="39928" checksum="9B8026B64D48DB84" modified="2013-07-24" version="1">MARIGIMTFLHNDNYGSILQAWALQNAVRSLGYDAEHIDYVPSQTEKMKNLLCSGNSPRLILDGMKKRSAARGLNEGFDEFRQTQMILSPVCRDQSALAHQALSYDTLICGSDQIWSPTWLNPAYFLNFTKKPKVAYAPSLGVSTMTDSAKGRKIAALIRGFAAISVREEEGAALLQSLIGKKPAVMPDPVMLLPREKWLELIGGDIPMGNDILCFFLADNPAYWTQVEQIRQKTGLGVRVIPRTESALQSAYPLAKGVTPAQWLSLIAGASMVLTDSFHAAAFSLLLHTPCTILRRYREDDPESRNSRVDQLLRTLQVANPTHPDFSVVDAQLAIQRQRGLDFLQSAISQAVSQATPAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8K6</accession>
    <name>R7I8K6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LHH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47816">
        <property type="protein sequence ID" value="CDE47816"/>
        <property type="gene ID" value="BN770_01377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026834">
        <property type="entry name" value="LHH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14411">
        <property type="entry name" value="LHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447658" description="LHH domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="LHH" evidence="2">
        <location>
            <begin position="294"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="404" mass="44241" checksum="B4D98BA36857B051" modified="2013-07-24" version="1">MKKLCSLLLALVLLAGCALGESTPEFRRMGDAALLPYLENSLYEQLVSDLDSSDYFVENVQAVYISQEYLDELAFNSQENVYFGYTLSELNAQFQGEKYIFTLGENNETVVVPWTDYDDAYDRVIRNVAIGTGVILVCVTVSVVSAGVGAPAVSMIFAMAAKDGAVGGLLGAAKSGVPAFIATAVRTGDMQQAAREAALAGSEGFKWGAIGGSISGGVTEAVGLKGAMLNGLSMNEAAQIQRESGYPLDVIKGFRTMEQYEACQKAGLVPKIVDGKMALIRQIDLDFVDEMGNTNLTRMQQGLAALDPATGEEYQLYYIVESRQSTIAILTKTEYMQSDSSEIWHTAAEMPQNDRWFFENQREDFWENMANIVKETFPTDELLERLFAPQVPDSEEKPENIAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8N5</accession>
    <name>R7I8N5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">BN770_01465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47975">
        <property type="protein sequence ID" value="CDE47975"/>
        <property type="gene ID" value="BN770_01465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="209"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="23"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="482" mass="50380" checksum="E5502FDD6B79C2F5" modified="2013-07-24" version="1">MIEIQNDQLTSNYASIKVVGCGGGGGNAVNRMVESGLRGVEFIAINTDMQALQMSGAQTKIQIGEKVTKGLGAGAVPEVGRRSAEESREEIAGALKGADLVFVTAGMGGGTGTGCAPVVAEIAREQGALTIAVVTKPFAFEGKQRMRNAEAGISDLKQRVDTLVVIPNDRLLQVVSKGTSMVEAFGIADEVLHQGIQGISDLIAVPALINLDFADVKTVMESGGMAHMGIGYGEGENKMIDAAKNAISSPMLETSISGARAVLINITGGKDISIIDINEAANLVMEEADPDANIIFGAGIDESMGDKVRITVIATGFEKTPFPPREPVKSARDINRDRLYGSNYGATGATGATGATGSYTPGNYGATGGYTPSYTSSDSYSSHPTMGVPQAPMTQQPAQPAYYAPQQPAQPQQPAYGQPQLFGNQPQQLDYAQQGYTGNMQPVQQQYAGGATGPMPSVQPQQPKRPTTDANGVPSFMKRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8S5</accession>
    <name>R7I8S5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000057">
        <property type="protein sequence ID" value="CDE47683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47683">
        <property type="protein sequence ID" value="CDE47683"/>
        <property type="gene ID" value="BN770_00101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="43" mass="5211" checksum="2B7F67F72A22CF9E" modified="2013-07-24" version="1">MQRYSSQQFILLKTPRPAEREVRFRPAPDKSVHRPYKEDESHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8T3</accession>
    <name>R7I8T3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sec-independent protein translocase protein TatB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46927">
        <property type="protein sequence ID" value="CDE46927"/>
        <property type="gene ID" value="BN770_01076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018448">
        <property type="entry name" value="TatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01410">
        <property type="entry name" value="tatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="100" mass="11395" checksum="F0070BCD1D2D5758" modified="2013-07-24" version="1">MFNIGFSELLLVLLVAFLVVGPKDLPKVARWLGRTVKKSRRLLNEIKKESGWDELEKEVRDVQHDVKDAVKQGDVSAELREAKKSVQDSAEKFDKDTKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8V4</accession>
    <name>R7I8V4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48284">
        <property type="protein sequence ID" value="CDE48284"/>
        <property type="gene ID" value="BN770_01617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="170" mass="19705" checksum="7F041CCE016370D3" modified="2013-07-24" version="1">MLTFRDATADQAGLISHIYATSWRKTYRGHIAQHYLDRLPDEYWVPSIRSWLSSGQLYGLMVYDDDKPVGCCIYGRGRDEDYGDWCEIVSLYLLPDTMRQGIGGKLLEEVIRLMKLDGYEKFYLWAIDGNEIADGFYRKHGFLRTDDVVDYKIGGEPVRDVRYTRVLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Z1</accession>
    <name>R7I8Z1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48334">
        <property type="protein sequence ID" value="CDE48334"/>
        <property type="gene ID" value="BN770_01658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="49" mass="5370" checksum="42C1BA897F63AAE9" modified="2013-07-24" version="1">MTQPDVLADAPQNPESTETPAIDYDALAEALTPIISAIIARQVNQRRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I925</accession>
    <name>R7I925_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47753">
        <property type="protein sequence ID" value="CDE47753"/>
        <property type="gene ID" value="BN770_01340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435587" evidence="1">
        <location>
            <begin position="24"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="250" mass="27590" checksum="7C66AB5C7A5A5201" modified="2013-07-24" version="1">MKKILAVLIALMLTALCCFAAVAEGTIDFSGYTLEELLTIRDDLTDEIASRPGGEKMVLGTGQYKIGEDLAAGVYTFKFVQNGDKDVTRSDYYVYENESMYKYDIDRLWLGDMPRVEGSLKGDGETRISLYPGEYLSLRYNGAEVARVGNVSERGNGYVPPEGTTIPKGNYTIGEEIPAGTYKIFFSGTATSRVRVFQDAKEASNTFNKGKETILDFTNTEGTVTLVEGNILRVEYNPIIMKKGGGFNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I956</accession>
    <name>R7I956_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000064">
        <property type="protein sequence ID" value="CDE47793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47793">
        <property type="protein sequence ID" value="CDE47793"/>
        <property type="gene ID" value="BN770_01359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="86"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="290" mass="31950" checksum="7449E287B365C373" modified="2013-07-24" version="1">MEYMVLPEQDGMRLRDVLRRVMGVSYTAMKSAKWNGGITVDGDVTPVDAFVRAGQVVAIRFRENAPAYAVKPYDLPLTIAHEDDWLFVIDKPAPLASQSSALHPDDTLENALYAHLRCPTDFVYRPVNRLDKGTSGLMIVAKDAHIQHRLQALLHTPEFIRTYQAVVEGCPDDDCGVIDAPIGKEDAASIRRIVTASGKPSVTHYRVLKRGKTRTLVELVLETGRTHQIRVHMASIGCPVVGDFLYGTEIPQLPGRFALHASALTLHHPMTGDWLSLTSPLPASLATLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I992</accession>
    <name>R7I992_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47087">
        <property type="protein sequence ID" value="CDE47087"/>
        <property type="gene ID" value="BN770_01143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026353">
        <property type="entry name" value="Hypoxan-DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04274">
        <property type="entry name" value="hypoxanDNAglyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18395" checksum="D2EF3721FD53439E" modified="2013-07-24" version="1">MVTHPFAPVVDENCRTLILGSFPSVKSRENGFYYGHPQNRFWRMLAAVYADEVPESIAEKTSLLLRHQLALWDVIANCEIDGSADASVREAVPVDITRITDRAHITRVLCNGKLAGTLYARHLQPMVGIPAHVLPSTSPANAIWTLPKLTDAWRKALTGENATFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9D3</accession>
    <name>R7I9D3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IstB domain protein ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000088">
        <property type="protein sequence ID" value="CDE48205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48205">
        <property type="protein sequence ID" value="CDE48205"/>
        <property type="gene ID" value="BN770_01574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="184"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="323" mass="37577" checksum="66CEFB6B2717C7DC" modified="2013-07-24" version="1">MRKEIMQALQQEYEQQRLKNSQEELRRRQEVITRCPEIGQYLAERQNLIFGGVRGILNGKAAADDLPARMDVMNRRIADLLRQSGFPADYLDPVYRCKQCRDTGYVGEPIREMCPCLRSAFYARLYREVGLGEKAEQSFAAFDPNVFSDQPLPGKKYSQRQLMDMLRHQCEQYAEKYPNAATMDLLLMGQSGLGKTYLMHAIAKRLLERGFNVMMISAYRFLDVARRAYFSGKQEEMDTLMDTDVLMIDDMGVEPLMENITIVQWFNLINERQLRGKGTVISTNLNVEELRRRYTERITSRLMDGKQCMLLQFLGDDVRRNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9D6</accession>
    <name>R7I9D6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000070">
        <property type="protein sequence ID" value="CDE47888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47888">
        <property type="protein sequence ID" value="CDE47888"/>
        <property type="gene ID" value="BN770_01416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="169" mass="18606" checksum="908BE67BAFF0AEC2" modified="2013-07-24" version="1">MKLDVLHALRDPGTAYAFAVEQTIAPQDVSGEEVTFDPVQLSGHLTANEDGSVVVEGSLTTTAHAHCAKCLSPASCPVTGDFRETFLHGGDPEDDEIFAYEGGQLDFAKLTLTHVLLNLPMRFLCKEDCKGFEEYEEVNQHKHCRDDANVQRPFAALQQLLAEKSDNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA39</accession>
    <name>R7IA39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p22 coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000097">
        <property type="protein sequence ID" value="CDE48341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48341">
        <property type="protein sequence ID" value="CDE48341"/>
        <property type="gene ID" value="BN770_01663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="270" mass="29166" checksum="FC0C8A47B9676D01" modified="2013-07-24" version="1">MAISSFIPKVWSARLQENFHKALVFGSLCSRNYEGEISQWGDTVHISNLSDITVRPYDPTKDLAEPEALSGTDIVLTIDHGAYYNFLIGDVDAAQARVDLMDGAMRNAAYQLAEDAEKYILATIRKGAGTKVSGAIPTADKGGLYGLLISIKNALDLKHVPRFERKLIVPIAIEGQLLMDERFVNGSAAAEARLAEGAIGRAAGFDIYVSADLTNEIIAMIPDAVTFANQIARTDAYRPEKGFCDGVKGLNLCGCKVVQPDGVYIHTITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAA6</accession>
    <name>R7IAA6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase GNAT family/NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48809">
        <property type="protein sequence ID" value="CDE48809"/>
        <property type="gene ID" value="BN770_01828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="143" mass="15983" checksum="37FE50301AFCD17D" modified="2013-07-24" version="1">MALIESAGAVLYTEDGGVRQYVLVMEKNGSFGLPKGHVEPGETLAETALREVWEETGICAILHTMQPVMVDEYPIAGGDVKRVSWFVAHYHDQTPLADPTQVLDVRVLPLREALRLLTYGSTRAILREVDRRLGDVRPRPKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAB3</accession>
    <name>R7IAB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47457">
        <property type="protein sequence ID" value="CDE47457"/>
        <property type="gene ID" value="BN770_01258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="480" mass="53877" checksum="5DC378DD95B8D3CA" modified="2013-07-24" version="1">MKQVFNPYLPAGEYIPDGEPHVFGNRVYVYGSHDRFNAAIFCVNDYVCYSAPVDDLSAWRYEGVIYKKKQDPLNKLGIRLLFAPDVVQGVDGRYYLYYAYDFLGRMGVAVSDKPQGPYEYYGHVRYADGREWGSRSGDEFPFDPGALVDDDGRVYLYSGFATKVPFIMSRFHNLRNSGGVGMELEQDMLTIKDKIQLIFPQKDNNPPKEFAGHAFFEASSIRKIDGKYVFVYSSENNHELCYAVSEHPLSGYRYGGTLVDLGDLYMEDGTTDEAHGTNYLGNTHGGMAELNGQWYIFYHRQTNQHSYSRQACAEPLKRTSDGGFQQAEVTSCGLNGGPLDGIGEYEARIACNLWSKHGVARYDKRFNKKEHPYFTQSGRDGDPAAVQYIANMRDGSVCGFKYFQMHGAKAIRCAVSGVCRGNIEVSDTPEFATLAASIPVEAGKTVMNVTAPFRMADGVKALYFRFRGEGAMNFFTFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAC1</accession>
    <name>R7IAC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein Hsp90-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47467">
        <property type="protein sequence ID" value="CDE47467"/>
        <property type="gene ID" value="BN770_01268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="631" mass="72295" checksum="85F7F483AB76FB48" modified="2013-07-24" version="1">MAIEMEKGSVSIDAQNIMPVIKRWLYSDKDIFLREVVSNGCDAITKYRMTNPDDESEMSVMVTVDKENKTLTISDTGIGMTEDEVKRYINQVAFSGASEFMKKFEGDEKKGDIIGHFGLGFYSVFMVSENVEIETLSCQEGAEPVHWESKDGMDFAISEGHRTAHGTSIILHISDEEKEFLELYRVREVLTRYCGYMAYPIYLMDANAKPVEREEEIPGETNEDGTPKKRKVVDEPKPSLINDTKPLWLKKPSECEDKEYIDFYHKMFGWEDPLFWVHLNVDYPFNLKGILYFPKLRNDFGKYEGQVKLFAGQVFVADNVKEVIPEFLTLLKGVIDCPDLPLNVSRSFLQNDGTVKKLSAHITKKVADKLCGLFNTERETYQKYWDDIAPFVKFGAMRDQKFYEQVKKAILYKTTDGRYLTLEEYKTANADKADKKVYYTNDPKRQAASVALYTNRGIDVVVMDHIIDGNFQSFMEYSGGEEGLTFARVDADVSGLLEDSEEGKELNQETIQAMFRKALGKDDLPVNLQSLSDAELPAMVTEDEQIRRMKEMSRLYGQSFDMPDRFTLVLNRRNKAIQELAARDPENETTQLLCQQIYDLARMSAQPLEADEITAFLKRSQKLVAMAVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAE4</accession>
    <name>R7IAE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000049">
        <property type="protein sequence ID" value="CDE47492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47492">
        <property type="protein sequence ID" value="CDE47492"/>
        <property type="gene ID" value="BN770_01271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="44"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="211"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="318"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="493"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="557" mass="61735" checksum="255057890B0FDF24" modified="2013-07-24" version="1">MGERSIQEKYQAWQKCPGMNEELLNQLKAMSPDELNDSFYRSLAFGTGGLRGVLGAGENRMNLYTVSKATRGLGRYLLETCEKPSCAVSCDSRIHSRDFAELTAATLAEMGIRVYLYRTLMPTPMLSYAVRHLHTSAGVMVTASHNPAKFNGYKVYGADGCQITIEAADRIYSFISAEQTLQPSLPSFQKYLDNGMISYIDDETIESYYQMIDGLRIAPTDERLHIVYSPLNGTGNVPVREMLKRMGNIDVDVVAEQEMPDGHFPTCPYPNPEIREAMKLAIEKTIATGADMCVATDPDCDRIGAGVRQGDTVTLISGNDMGVLLLDYVCSHRKAQEGELPPVAVKTIVTTEMAVPICKKYGVELRNVLTGFKFIGEQIGLLEKEGHTERYIFGFEESYGYLSGTSVRDKDAVNAAVLVCEMAANYKAQGLTLLDKLEQLREEFGFYAQRLLTFQYEGESGAAKMADIMRKLRAPLDTFQDAHFPTATRIDYQNDETGLPKSDVLSFALADGSKIIVRPSGTEPKLKAYLFARGENQAAAEKVLDELETLMNGYCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAJ2</accession>
    <name>R7IAJ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48914">
        <property type="protein sequence ID" value="CDE48914"/>
        <property type="gene ID" value="BN770_01855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="706" mass="80326" checksum="F5E6D1DB40E918DB" modified="2013-07-24" version="1">MALRKKPPTTLLLTDMSSLYGYIYCMLISEGLSGMPLYGGALYMIGRVTTVFAQTFSPEEAIYLPKALRWMRVPLMILLLLLSLCLVVLYPMSFGSTQMWLIFSVVLSMQLRDSLCQRMGRLCLDGRMEQTTFLCLSGALHGCMMALQALILAVNLPVQLSVPMMIGYLLCGMAAFYSTYAAYEERAVLPRPNLEEAHFTLETIHRANALSAFERLSMVLLTAMEMTLIVMYTFLATTAEQMLIRMAIAVLTTLLCEELATLLLKKREKKNKNEPISLLLMGMFLWLYGLWIFSRMLRHHTTDISITYFCLALCSVGCAVCKVCLSKMESPMGAVAKFTSGQEIPGYRLMRRVSREVASLLGQMLALVALTVLCFLAGQRLPHTAEEIAASFQPVMVVPALITAFIALLCVLRFPLSNRYMQKVLRFLHIRESGEENKALEQQLEEVVIKRHVQPLGIRFLMAVMRPFFRHTVKGAENIHPDDSNPLVFLCNHGEIYGPVAGMLFCPVPVRPWTISDISIDPDEVAQYVYKYTFSQMKWLGPLRWPISKLCGPLSVWAMKSVECVPVYRHKPRELTTTFRKSVEAMQAGDNLLIFPENPDADPNRPGYEHGRPGELFRGFTMLAQVYYARTGKCCRFVPMLAHKGMRTLSFGTEIDYDPEKHPIEERDRVVEEAQRQMWEMFDREEKLYQEKKAKEKAKKAPEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAP2</accession>
    <name>R7IAP2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recA</name>
        <name evidence="12" type="ORF">BN770_01291</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47577">
        <property type="protein sequence ID" value="CDE47577"/>
        <property type="gene ID" value="BN770_01291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="52"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="216"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="82"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE47577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="388" mass="41786" checksum="4297F6DCF6B145C2" modified="2013-07-24" version="1">MAAKKPAKTEKAAPVTGAQEEKLKALEHALADLDKQFGKGAVMKLGEHAEQNVQVIPTGCLTLDEALGVGGIPRGRIVEIFGPESSGKTTVALHIVAQAQKMGGIAAFVDAEHALDPVYAKNLGVNIDDLYVSQPDTGEQALEIVEALVRSGALDVIVIDSVAALVPKAEIDGEMGDSFVGLQARLMSQALRKLAGIINKTGCVAVFINQLREKVGVMYGNPETTPGGRALKFYASVRLDVRRGEQLKNGSEVVGNHTKVKVVKNKVAPPFRVAEFDIVYGEGISREGTLLDMAVERDIIHKSGAWFSYKDQRIGQGRENTRLYLRDHPEITDEIDAIIRQEIFADKPAKPIAPEEDPGELPDEDEDDLALLEADLGDDAGVAPLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB10</accession>
    <name>R7IB10_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP_bind_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48735">
        <property type="protein sequence ID" value="CDE48735"/>
        <property type="gene ID" value="BN770_01796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="43"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="290" mass="33433" checksum="F09C657DBAA2DD15" modified="2013-07-24" version="1">MPRTLSPAARIERSILSDFRKPLWRPFVRGIKQYKMIAPGDHIAVCISGGKDSMLLAKMMQLLQRHTDIPFETEFLVMDPGYNAENRQRIIDNAALMEIPIRIFDSSIFETTKIAERNPCYLCARMRRGFLYDRAQEMGCNKIALGHHFNDVVETTVMGMFYGAQLQAMLPKLHSRNFPGMELIRPMYCIHEEDICAWRDFNALHFIACACRLTEERDKSGDGIGNSKRAEIKQLLKTLRETNPDVEKNVFSAIHAVSLDTMPGWKIGEKEYSFLDDYDHWEATHRPADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB85</accession>
    <name>R7IB85_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-galactose-binding periplasmic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-galactose/ D-glucose-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47747">
        <property type="protein sequence ID" value="CDE47747"/>
        <property type="gene ID" value="BN770_01334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01539">
        <property type="entry name" value="PBP1_GGBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044085">
        <property type="entry name" value="MglB-like_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447754" description="D-galactose-binding periplasmic protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="9">
        <location>
            <begin position="25"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="357" mass="38629" checksum="2A6CDF1CE4BFC241" modified="2013-07-24" version="1">MKKLVALLLSVMMCFACVSALADTYVSWYTYGDVYLSSVRSEMEADFAKLNLTINGSDANGNQQVQSDFISTALMNNDCEAIVVNLVESGAISTAQTIMNQIQAAGIPTVWFNRPVSTNNEEAANLFLNNPASAFVGTNFEDAGVMQGELIGQYLVEHYNDIDLNGDGKISYIMFKGDEANQEAIARTALAVEYANKALVAAGKPEIEFYDASNANKYLVDPNGSWSNVFSSEQMQTVLSMYNEGNGNMVELVICNNDDMAYGAVMALQNAGYNHGEGTTAIPVFGVDATDVAKDLINNGYMVGTIKQDNVGMADAVATITANLIAGKENKFEGLNENYVIVDNWFVQIPYAVYTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBA0</accession>
    <name>R7IBA0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47767">
        <property type="protein sequence ID" value="CDE47767"/>
        <property type="gene ID" value="BN770_01349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448129" evidence="1">
        <location>
            <begin position="32"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112378" checksum="A0BB52B5416527B4" modified="2013-07-24" version="1">MLSGKKILSAVLSAALLLPAASALAEDDAFAAEIERRYTAPSIDSRSEVRWWMAEAGHTDETIRAEIQAMYDGGFRGVELCAQGEDEISETDYGYGSAQWDHDLKLAMNTALDLGMTVSLTSGTNWATANVPGLDPHSQGASQIVVDIVEYIKAGASRSGAIPMQKKVGSKVYPIEPTAKLIGVFAVPQTSGNKAKPIVTDGTGIIELTDKLVWEADGTITLDWTPENAESKYRLFYYWQQGAMQESHPAAETAYCINYFDEAGIEALKEYWLAHILDDEALNAKIQAGDVQLFMDSLEISTEYGCAFWCDDMAEEFLARKGYDIRPYLYLTIGLPDLFYWDAVDYGSYDLADKTMREKVLNDLFDVQTQLYRERMLEPLRAWLHEYGIKTRAQISYGQRLEISEPIMSVDYPEAEILNQNNQVDMYRLWTGGAKLQNKVLSSETGAYGGYAYTEQDHLMEAYNLFAAGFNRIVWHIWSAQYGPGTDNRWPHYTASGAVYASFYAFGPHEPSSVDYPSFNAHLGRICQLLREGVSRTDVGMIYMSYQQPMPTSGNHGGENWLLNHTTGFFPSTTLQDNGYTYDYFSPDFLTADGVSYAAETGTLEQAGYQAIVLWQEQLALDGAKALLDLAKQGMKVVVVDGAAVQTPYNDGGEAALADVMAEMKALPNVYSAKDADDAARVLQSAGVKPYAGFAEPNRQLLTQTRRDGDTEYLYVYNYCDGSYVSVWSQGEKQDTHGNTITTEMVVDGTWIPYQLDAWTGETKRLGVYRHENGSTIFPLTLDYGNVALFVFRACEADSELHAVETNAADIFSDGSSLSAKVTASGEYQAQLSSGETRQFAAQVPDAFEITDWDVTVMKHTASGQVNERMETLFGQTITETQVATDITPVTLHLDALKTWNEIPELGERTVGQATYKAVFQWDGTADGAYIDFGKMSESMQVFINGEKTGDLSMTKAVMDITPWLKNGENTIALLYSSSLANAGGGAGGGDWYGYRYGLQAYGPAQAVVHPYCLIPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBF3</accession>
    <name>R7IBF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48915">
        <property type="protein sequence ID" value="CDE48915"/>
        <property type="gene ID" value="BN770_01856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="167" mass="18679" checksum="7836A54BB85C8857" modified="2013-07-24" version="1">MIADEQVTTEPSSLFSAQDQAAIRAQLKKRLILVLIPVLALLGAAIYFAIQRNEVATDVLTIVSLSVLIFCYDLFLKPLRCYQRHLDNVISGRRRAVDLPFLAISDDISLVDGVPYRAMTCTDLDAKGRPYDRLFYFDAEKPFPAIAAGETVRVVHHELDVSDVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBN6</accession>
    <name>R7IBN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000123">
        <property type="protein sequence ID" value="CDE48896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48896">
        <property type="protein sequence ID" value="CDE48896"/>
        <property type="gene ID" value="BN770_01853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="85" mass="9331" checksum="4A257A8CFF1A1EDC" modified="2013-07-24" version="1">MTKQKAYVQFSKRIVLLVTIAVTAISLLAVVLCFFRSDTEALISTVRTYINYATIVFAAYSGNSVFEKWLTQGKSADAAENTAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBX7</accession>
    <name>R7IBX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49389">
        <property type="protein sequence ID" value="CDE49389"/>
        <property type="gene ID" value="BN770_01994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26041" checksum="06ED0ED913D4D4FF" modified="2013-07-24" version="1">MLPVIGVTASVSDDRLSFQQKRMYCEAISACGGLPLILPPQEDVSRASQVLSLLDGLLLAGGDDIDPAYYDEKTLPECGLITPIRDIWEMPLCWEALHRHLPLLGICRGLQVLNVALGGSLVQDLPSQCPDSPVHHQQTQPPEVATHPVRVDAQSRLARIIGAESLMTNSHHHQAVKQLASGLTATAWAQDGIIEGLEKIDEPFCVAVQWHPERLWSQPDGLPHRALFAALVDAAKSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC01</accession>
    <name>R7IC01_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ORF">BN770_01832</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48813">
        <property type="protein sequence ID" value="CDE48813"/>
        <property type="gene ID" value="BN770_01832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="4"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="397"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE48813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="620" mass="68800" checksum="800F20896E2D1174" modified="2013-07-24" version="1">MMKDLVVIGGGHAGCEAALAGARMGLDTLLLTMNMDGIALMACNPVIGGSAKGHLVRELDAMGGEMGRAIDDTFLQSRMLNMSKGPAVHALRAQADKQQYQNRMRTALMTQDNLTVRQGEVAAIDVENGHVTGVTTTTGQHISCKVAVVACGVYLRSQIIIGESITPGGPQGLMSAPNLSGSLTRIGFPLRRFKTGTPARIDVRTIDFDEMTPQPGDEPVTPFSFMTDRALHNTYACYLTWTTPETHDIIRRNLHRAPLYSGKIHGIGPRYCPSIEDKIVKFADKERHQVFLEPEGMQSREWYVQGMSTSLPEDVQWEMYRSVPGLRRCELTRLAYAIEYDCIDSRQLRPTLESLDVRGLFFAGQINGTSGYEEAAAQGLLAGMNAALTAQGKPPIVLTRDQAYIGVLTDDLTTKGTDEPYRMMTSRAEHRLSLRQDNADLRLTRIAYEAGLATRERMERTERKASETAQLLGELRKAKYTPGVTLNDWLEKHHQPEAQNGLSAVELLKRPEITLSALAELSPEIRQFGKPAQEQVEISVKYEGYLERQETLIRHARQMEETLLPEDLPYEEVTGLRIEARQKLMKQRPRSLAAASRIPGVSPADVAVLMVFLEKHKGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC36</accession>
    <name>R7IC36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48067">
        <property type="protein sequence ID" value="CDE48067"/>
        <property type="gene ID" value="BN770_01524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="176"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="276" mass="32143" checksum="7AD4834A4C45721A" modified="2013-07-24" version="1">MDDQNIRLNIAGHAHYEYAEVARSYVPVHWHDALELIYILSGELTVETEQHRWQLHAGQCICISPYVLHATISLSGNNALVLQIPTEKLGDFAPETRSRQFIWDAETTNPTMMAAIERVKQKLLQMQHTASSNSPFRDIRMASLLLEITYLLYEEFSCPVTEGSIFRREKNRQRLSAVIAYTEAHYREDIALSDAAATLHMHPNSFCRFFKENTGVTYLNYLNEYRLSKVYEDLVTTDVALHEILEKHGFTNYKLFRHMFAERFHTTPGRMREELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC45</accession>
    <name>R7IC45_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48077">
        <property type="protein sequence ID" value="CDE48077"/>
        <property type="gene ID" value="BN770_01530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="760" mass="80884" checksum="B71D8442D693DC19" modified="2013-07-24" version="1">MADILQVNTELPADFTPTAPSGLTDEEAASRKPNISHHRPDKSTAQILAENLFTPFNGLNVALAVCLALVGSWRNMLFLGVVVSNTLIGTVQELRARKTIRKLSLLNAPTAHVLRNGQEKTCAPDALVKGDLVILRAGDQVMADAVVTSGQGAANESLLTGESTPMRKQPGDFLLSGSYILEGTFTAQLVYVGDESYAARLTRSAKEIRRPKSVLMTEVNRLIRIVSAALIPIGLLLFCKQFFLQHLPLTTAVPTSVAAMIGMIPEGLILLISVALAVGVIKLGKRNTLVQELYGIETLSRADVLCLDKTGTITTGKMTLGSLLPLSGDEGEMRTQLRRFLSSMDERSGTLDALRAEIPDVQGEKPVAVLPFSSERKKSAVSFADGTTLILGAPTFVLDDAHLAPIRKTLSDCAGRGLRVLVLAEADGCVTETDAPAVTRVIGLCLLTDEIRPAAQETLHYFHTQGVALKIISGDDEKTVAAIARKVGLSGGAVDASTLSDAELVDACERYAVFGRVTPTRKKALVEALKANGHHVAMTGDGVNDIPALKAADCSIAMAGGADATKQAAQLTLLDANFANMPLIVAEGRRVVGNITRAASLFLVKTLYSFALALLTLLFPVEYPFQPIQLTLISSLTIGLPAFLLTLEPNQDRIQGRXXPADARTESGPHTGQFSAHGADAGDSRRGGGVRLRHGGNGRREFRLGYGGLQDAGGAVRGRGRADDALFRLRPADDAARGGVCRDDRRIRAGGMLFQADFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICG4</accession>
    <name>R7ICG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49265">
        <property type="protein sequence ID" value="CDE49265"/>
        <property type="gene ID" value="BN770_01957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="97" mass="11552" checksum="6EC58808E6F6B852" modified="2013-07-24" version="1">MATALWLRTIRHHRIDRQAVEPCTRDNPHDALEEACRKLDISHPIWLDKNEREWEEFGQTRFLPDAFLDSVDFDRMEIEYIDPDAKKKGSNDPRNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICI9</accession>
    <name>R7ICI9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA replication protein DnaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000088">
        <property type="protein sequence ID" value="CDE48207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48207">
        <property type="protein sequence ID" value="CDE48207"/>
        <property type="gene ID" value="BN770_01575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034829">
        <property type="entry name" value="DnaD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158499">
        <property type="entry name" value="SSF158499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01446">
        <property type="entry name" value="DnaD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="2">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="DnaB_2" evidence="2">
        <location>
            <begin position="207"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="499" mass="57854" checksum="C1DB6D70E2626C5A" modified="2013-07-24" version="1">MAMFSFDEQAALFDVTPLPNQFILNYLPEASGDAVRVYLFGLVACYHHEAISDLQQMARELNMTEDDIRAAYRYWERKGLVQRVADNPPQYRYQNIYQVMMTGAQAQIDPAYEQFAEAIYGVFDNDRRLHGKDVSQCYEWVEQMRLPPDVVIAMMRHMVQKHGKNVSMKKAEQMAMRLADEKVQTVEEAQEIFRRDQTVWSGSKKVLEKLGLRRYPTEPEQTMYSKWLVDWQFTPDAILRAVDETIKSSNPSFAYLDGILKRLHEQGNVRTEQDVSGDIEGSRKENEPIKQFLRALGNYSITINDTTKATYKSFQTMYPDPVILLAAQQCAKWGMTTLQDVMQTLMAWQNRSLRTLPEIDAYMRQIDEQNEFLIVLYQAMQLDEKTKPNAADRALVKQWTEEWRFAQMFVLGCAPWAAGKKSPMAYLNKMLKVFREKGITTMEAAKAERERFEQQPSQSTAPAARAPKVVGEQQYTQRTYTPTQDAMDAMMQEWEESHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICK4</accession>
    <name>R7ICK4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000090">
        <property type="protein sequence ID" value="CDE48222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48222">
        <property type="protein sequence ID" value="CDE48222"/>
        <property type="gene ID" value="BN770_00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="356" mass="40091" checksum="627B809960F9D9C6" modified="2013-07-24" version="1">MRRYAYLDHIRWMTVLLVIVYHVCYLFNGVGIFGGVPDARNLPFLDTISGTVYPWFMVLLFVVAGMCARFALVQQGNRAFLRNRARKLLVPSTLGLFVLQWVTGYLNIRMGGAVDTIPKPLLYPISVLSGIGPLWFVQLLFLFSAILVLIRRIDRNDHLFRLGERTPSWLICAFALLIWGAAQVGNMPVITTYRIGIYLTAFLLGYAVFAHETVMERVERMRWGTLAVALIGAAAYGAWTNGQNFTDAAYLQSLWANVYLWAVVLAVLGNARHYLHQETAVSRFFTQRSYALYVVHYPVLLLTALLLTERTTLPAATTYLLTLVIGFGATLGLSEVICRIPGIRYLTLGIRKEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICL2</accession>
    <name>R7ICL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative kanamycin kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49335">
        <property type="protein sequence ID" value="CDE49335"/>
        <property type="gene ID" value="BN770_01982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024165">
        <property type="entry name" value="Kan/Strep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000706">
        <property type="entry name" value="Kanamycin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="6">
        <location>
            <begin position="42"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000706-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000706-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="261" mass="28745" checksum="329F7E6B8F27E430" modified="2013-07-24" version="1">MIPAAIQALLPQYPGEENRIGHSGAQVVMYEDCVLKVQPDTGNAANEGIMLRFLKGRLPVPEVLAEAVQGGMRYLLMTRLRGRMLCDETFLDNQPLLARRMADAAEMLWRVDIDGCPCSYALDDVLRKAEADIAAGRVTIDTANQPETYGAGGFASPEALLAWLKANRPPETLVLSHGDFCLPNILADEKGIVGFLDLGQAGCADRWRDLDQGLWSMWANTTGLFGGRARLFDRNALFSALNLPLDEEKLRYYSLLSELCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICW8</accession>
    <name>R7ICW8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48382">
        <property type="protein sequence ID" value="CDE48382"/>
        <property type="gene ID" value="BN770_01673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="245" mass="26971" checksum="CBE9B0FFA9AE0878" modified="2013-07-24" version="1">MKHAELLSVRDLHVQVGEKEILHGVNLSVGTDETHVLLGPNGTGKSTLGYAITGNPAYQVTRGSITFDGEDITSMPVNERAKKGVFLSFQNPLEVPGVTLSAFIRTALEQKSGSRIRLWDFKKKLKETMALLSMDESYAERDLNVGFSGGEKKKAEILQMLMLEPKLAILDETDSGLDVDAVRTVSEGVRLFREKTHGSLLIITHSTRILEALRVDRTHVMENGVIVREGDAALVEEINEKGFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDI8</accession>
    <name>R7IDI8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase subfamily IA variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48642">
        <property type="protein sequence ID" value="CDE48642"/>
        <property type="gene ID" value="BN770_01763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="211" mass="23572" checksum="EFB8ABFCE264AF26" modified="2013-07-24" version="1">MKPVIFFDWDGTLADSMNLCVAEIRQALITMHLPDLPDDVLRQCNGPTFEQSLDILHIPHDRAQEYMTTRLTAELALVPTVNRLFPGVREMLQTLREYADLCIVSNGEHDYIALCLQVFGLTDVFVRTATSVPGRTKGENLRALLDDLRPERAVMVGDRLGDIRAGQENGLPTIAACYGYGNDAEYNQASLRAESVADLTRQLVDFCRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDK0</accession>
    <name>R7IDK0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0291 protein BN770_01771</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0291 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48652">
        <property type="protein sequence ID" value="CDE48652"/>
        <property type="gene ID" value="BN770_01771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01103">
        <property type="entry name" value="UPF0291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009242">
        <property type="entry name" value="DUF896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37300">
        <property type="entry name" value="PTHR37300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05979">
        <property type="entry name" value="DUF896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="70" mass="8184" checksum="FCC1B9708768F0AF" modified="2013-07-24" version="1">MEKHKIDRINELARKKKSDGLTDEEAAEHAALRQEYIAGFRENMRQVLENTYVQRPDGTKTKLQKKTPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDM0</accession>
    <name>R7IDM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NtpG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49403">
        <property type="protein sequence ID" value="CDE49403"/>
        <property type="gene ID" value="BN770_02001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="107" mass="11434" checksum="5C2FF772DA976148" modified="2013-07-24" version="1">MGVVGERDAVLAFKALGMRVIAVSTPEETTKALHRLYSEGIPVIFLTETCAQQVPETLERYKTDPKCAVIPIPGSSGANGFGLSRVKANVEKAIGADILFNNEKEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDM2</accession>
    <name>R7IDM2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cellulase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48672">
        <property type="protein sequence ID" value="CDE48672"/>
        <property type="gene ID" value="BN770_01781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="326" mass="34446" checksum="BCD3999AA8F900F1" modified="2013-07-24" version="1">MLELLKKVLKPVAPSGLEEPVAAVIREEVAPYVDSIETDALGNLICVKNGTEANPEKIMLSAHMDHIGYIVTGIEKEGFLRVTNVGGISPTMSLTRHVSFPNGVQGVVVSEVSKDTAMKDLFVDIGAQDKADAETMVRVGDVCVYANDCFQLGANRVASPAMDDRAACALLIRFLQTVGATKQTIIAVFSVQEEVGCRGAKVASFAKAPDKGIAIDVTAWGDTPGTKQPDIKLGEGIAVKVMDRGSISNPDLREALLAAGAQAGVKTQREVLPFGGTDASAMQTSRGGIPVCTLSIPCRYVHSACEVVDLRDVEGGVALLKKYFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDV0</accession>
    <name>R7IDV0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_02054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49621">
        <property type="protein sequence ID" value="CDE49621"/>
        <property type="gene ID" value="BN770_02054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="202" mass="22304" checksum="FAA0DE01518E25E1" modified="2013-07-24" version="1">MRDLLYLLLGYLSGCVLYAEVFSRVFHKEIASAAKDKNPGAANAFVHGGFWCGVLTLAGDMLKGMVPVALYMHYLPETLLTPLAPLVLCAPVAGHVFPATRSFKGGKGIATTFGCLLGLLPFWTPVLVLACIFIFYSTILRITPNLSRTRVTYLTLPLGMLLMEVPLWICFGTLCMTGMVLVRLHISTEEREKPAVHLLWWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEA1</accession>
    <name>R7IEA1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">BN770_02208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="CBJB010000158">
        <property type="protein sequence ID" value="CDE49955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49955">
        <property type="protein sequence ID" value="CDE49955"/>
        <property type="gene ID" value="BN770_02208"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="195" mass="21177" checksum="D7D035B1C7BF9313" modified="2013-07-24" version="1">MRTAVITRTTRETDITLTLTLDGSGKTSLSTGIGFFDHMLDALCRFGQLDLALTCRGDLHVDAHHTVEDVGICLGRAIRDALGDRAGIRRTASAYMPMDEALAFAALDISGRPYLVFDAEFAAPMCGQFDTQLAEEFFRAFAVNAGLTLHLKVLYGKNDHHKLEALYKALGLALRDAASIDNRIEGVLSTKGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEP1</accession>
    <name>R7IEP1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="17" type="ORF">BN770_02133</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49783">
        <property type="protein sequence ID" value="CDE49783"/>
        <property type="gene ID" value="BN770_02133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="267"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="555"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDE49783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="595" mass="66815" checksum="67EFEA6EDD4C5BA7" modified="2013-07-24" version="1">MRFPPSWLDELRARADIVQIVGQYVQLKKNGRKYWGLCPFHGEKTASFSVDPEKQLFYCFGCKAGGSVIHFVMEIEHLPFPEAVKHLADQLHMPLPQMEADPDYQRRQTQRERLLACNRDAAHFFYETLFTPAGQPMLDYLKRRGVSDGVIRKFGLGAAPNSWDALTRAMQAKGYTTEELQMAGLIVIKDAEEATADRPARSRRAFDMFRNRAIFPIIDQYGNVLAFGGRAIENVQPKYLNTSDTPIFNKRLGVYAANLLRKERHLERVVLVEGYMDVVSLTQFGVTGVCATLGTALTNEQAKLLKRFAPMVYLSYDGDSAGQHAILRGLDILEAEGIPARVLDFPDGLDPDEFIRRDGKEGFDKLPALTPQAYRMRRLRAEHDLTTQEGRTAYAKACAAILRNLEPVEMENALQELIVQTGFSRDVLIAQIGMTPPKDITSAPPLPARIARPPATPVPEPENADEDVRAEELLLSLIATSRLPEDLAQEDDFRDPLLKELFLQLQSGVSAASLVESQSDEVVRARVSHLLMAQSGESTDQMLQMAHDCLSRMRLKRARAQYDEIMKRIKTLSGAEKMQALDEAKQLTATINRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEQ1</accession>
    <name>R7IEQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily (Subfamily IA) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49062">
        <property type="protein sequence ID" value="CDE49062"/>
        <property type="gene ID" value="BN770_01906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011951">
        <property type="entry name" value="HAD-SF_hydro_IA_YjjG/PynA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02254">
        <property type="entry name" value="YjjG/YfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="227" mass="25050" checksum="BC860582C3FE53A8" modified="2013-07-24" version="1">MKYRYLLIDNDNTLMDFHAAEHAALREALTEAGIEPTDAVCARYSAINDALWKALERGETTHAALKITRFAQLLEEYPAENVCAPRLALRYSHYLGTHADLMPGAEAFLRRLHGQMKIVLVSNGDSVIQRNRLFRCVFTPLLDNIVISSEKGVSKPDPRLIEIALAECGCTDKTEAVMVGDSATADIPAAIKAGIDSIFVDWKDIGCQQATYTAKNLAEVEQILLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEV1</accession>
    <name>R7IEV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49848">
        <property type="protein sequence ID" value="CDE49848"/>
        <property type="gene ID" value="BN770_02163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045706">
        <property type="entry name" value="DUF6062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19538">
        <property type="entry name" value="DUF6062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="29473" checksum="CFA170D7A8821FA9" modified="2013-07-24" version="1">MRYHIDTIPVWDAAKIDGECLLCALQRRVELQQIEYSLGASVMEPDVRIQVNKKGFCQHHQRMLFKGDNRLGHALMLESHLTETRGKLSKAFNDIRKAASGNSSFLDRLSGKAPSPAKAMEAAVQELDALCSTCIVCNAIEDNMNRYLHTFFHLYQNDSEFRKHFAQSKGVCLPHAVQLLKLAPQELPSRELSAFADLICNLETEAFDRIQGDVSWFIKKFDYRFQAEPWKDSRDAVERSVNKLRGWCVGKEPNPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF24</accession>
    <name>R7IF24_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50051">
        <property type="protein sequence ID" value="CDE50051"/>
        <property type="gene ID" value="BN770_02252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27536" checksum="CF180B5F927C5F6E" modified="2013-07-24" version="1">MKKAIIHQHYPLDYAGEEALNSICTNLAFIGTDKRKIVITSNSQSEGKSWMTMHIAENMARRGRHVVLVDADMRRSFMVQRYKLELEGEGLGLAHFLAGQCDLNDVVYESDVYGMCLIPAGRDVVNPINLIDSSYFEQMLEALAQSFDMVIVDAPPVGMVIDAAEIAAFCDGSVLVLEYNHTRLREVAECKRQMEKSGTPVLGCIINKVNFNALSAKRYYNKNYYSHYTKGYYKHDDKDNQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF70</accession>
    <name>R7IF70_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50106">
        <property type="protein sequence ID" value="CDE50106"/>
        <property type="gene ID" value="BN770_02280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="275" mass="30375" checksum="D504A404F5E7D6B6" modified="2013-07-24" version="1">MSRKIRFSKESQSSLNDFFVHRSPEQPKSKAEENLPAGILSAFRTDVGKVRANNQDAPIVSEKLRLYGVADGMGGHKGGEVASTSARDDLLRELEGKTPSVATLSGAIEEVNRQIYHQQEHDDALTGMGTTLSVLWMSDNFVYIGHVGDSRVYLLRDGEFKQMTLDHSLVEQLVREGVLTEEEAQNHPMRNIITRAIGTDESVEVDVVVEERRKGDLWLACSDGLHGLVDDRQMRDALRQYAPEKAADVLLKAALDAGGRDNVTLVIVHDGEEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFB1</accession>
    <name>R7IFB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50280">
        <property type="protein sequence ID" value="CDE50280"/>
        <property type="gene ID" value="BN770_02343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435816" evidence="1">
        <location>
            <begin position="26"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="390" mass="43087" checksum="AA6CB968D2F14F1F" modified="2013-07-24" version="1">MRKYTRIGTFLLALVMCLTMLTAQAESELPLEVADLFTVKAWAHYAIANQPDMPENKAFAVMQEKSGYEAVLLVMRNTKSETNVLVLAEKSSAQAEWKITMRNWGAVEQGDANVPQLAVLADGRFAIYYPNGDSAYFTHEANGWQLTNLSFGYTTQVEVTRSGMTFLTLADNGKWVKTTVSGVVETAMAQFSMDRFPRTVEAAREHLTNPPTIPDSPWSWTYPYGFPQPSQYAKLAAGKQYAVYSAPSDTSFRAANGKALLSTNDWVQVFFEEDGYLLVQYAISRHQYRIGYITADAVKDLSEVNAIGSWANYPAQVLRTSSLTDDPLNSCGAVMTLQQGQQVTYLGQLGLEWAFVETTTAQGKQIRGFVELSNLNVTLPTDTTGDGING</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFF3</accession>
    <name>R7IFF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low molecular weight phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50330">
        <property type="protein sequence ID" value="CDE50330"/>
        <property type="gene ID" value="BN770_00159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="4">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="155" mass="17807" checksum="26E19A697D552058" modified="2013-07-24" version="1">MRVKILFVCHGNICRSPMAAMVFRYLAQQRHVSGEFEVDSAALSNEEIGNGIYPPARRILVKHGVPCTEHRARQITPEDFETADLIIGMEWGHLKKLRALCPKEQQAKLHLLLDFAERQGDIEDPWYTDDFDRAYRDILRGCEGLLRNLTENKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFL7</accession>
    <name>R7IFL7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="11" type="ORF">BN770_02293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50128">
        <property type="protein sequence ID" value="CDE50128"/>
        <property type="gene ID" value="BN770_02293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="10">
        <location>
            <begin position="197"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33621" checksum="2EBBB64ABE03AE37" modified="2013-07-24" version="1">MIDLCTLGTGGTMPLPDRALASLYVRVGGRAVLVDCGEGTQIGIQRLSWGIQCIDAILLTHYHADHCSGLPGMLLAITKAGRTAPLHIYGPIGLERVVAGLRVIAPSLSCPIVLHEIIDDYSPFAAIGLTITPFPLRHEMPCIGYQFHLPRPALFDPIRARAQEIPVKLWRILQRGETVSMDGQTYYPHQVLGQPRRGITFVYATDTRPVPGIVRMGQDSDLMILEGMYGAEEKLPLAHKNCHMLFREAAQLARDAGTKRLLLTHFSTSIETPEEFLPNAQAVFPETTCATDGMTLTLRYPEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFW6</accession>
    <name>R7IFW6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="12">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BN770_00160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50331">
        <property type="protein sequence ID" value="CDE50331"/>
        <property type="gene ID" value="BN770_00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02491">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE50331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="168" mass="18248" checksum="D82AA64F210483B4" modified="2013-07-24" version="1">MEIRIFGLADDSIVDGPGVRYTVFVQGCPHHCPGCHNPASHDFAGGTLMDTDGIIRKIGENPLLDGVTLSGGEPMCQPEACRTIADAAHAKHLNVWCYTGFTLDALLKENNPARMALLHGIDVLVDGRFVQEQKSLSLLYRGSSNQRLIDVPKTLAAGEITLWTPPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG46</accession>
    <name>R7IG46_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">BN770_02452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50600">
        <property type="protein sequence ID" value="CDE50600"/>
        <property type="gene ID" value="BN770_02452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="101" mass="11375" checksum="D821352BF49753F4" modified="2013-07-24" version="1">MKSVHDVIIRPVLTEKAYDGFADKKYVFEVAINATKTEIKQAVEAVFAEDGVKVEKVNTLRTIGKIKRQGRSEGRTPEVKKAYVTLKKDSKPIKFFEGMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG57</accession>
    <name>R7IG57_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50293">
        <property type="protein sequence ID" value="CDE50293"/>
        <property type="gene ID" value="BN770_02352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="75" mass="8454" checksum="45A36CDB615292DD" modified="2013-07-24" version="1">MNDLQVVEQELSDAIMREMRQAMQTKNISLTLLADMSGVPLETVERLESGRLDVKLDEAMRVLGKLELTLKVVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGE4</accession>
    <name>R7IGE4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000180">
        <property type="protein sequence ID" value="CDE50859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50859">
        <property type="protein sequence ID" value="CDE50859"/>
        <property type="gene ID" value="BN770_00016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436568" description="F5/8 type C domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="713" mass="79726" checksum="9470C3486D702E4D" modified="2013-07-24" version="1">MKKWLIALLTLLALSLSVAFAAEANDITEDCKFKVCSSGRKYTLMTDKKYTSYWESNKIKTPWIAITAPEGKPIAGLYVCFGNMPESWEIQTSDDGKDWFTAVPGDTRFLHAYVALPQPAQHVRLAVTSEKKTALRINDLFVLSEGDLPDWVQVWQPTEEKADILFLSTHPDDELIFFGGAIPTYAVEQQRKVVVAYFTRSNTTRSSELLNGLWHMGVRTYPVIGNFKDSYAKNLKAAYKSAGGKGKVNEWIVGLYRQYKPEVVVTQDTNGEYGHKQHMMIADAAQNCIALAANEDEFTASTIAYGTWQVKKLYLHLYPENQITFDWTVPLKSMNGATGIELAEEAYTLHKTQASSGMSVTETGTKYDNRVFGLAFTTVGEDVRKDDFLENIYDAPGSYDAAANNVEATPAPTEVPAYMAHMPALNAKGFLDEGEYIYSSEDEGLWIYVSQTSKVIIQRKYDATQPLTWFEADLYGDLDAGEMLRTVQNDPEKMGKVRVDATETAKKHNVVFAMNTDYYTYRVAVNNNRHTGIVIRDGRILYDDPYTEKQVTNSMFPNLDMLAFMPDGSLKVYHSWEKTAQEFIDEGVQTVYSFGPYLLLDGKVSERAYANNENKNPRCAIGMVEPGHYVAIMCEGRLKRSAGVTISYLAKMMRAKGCQVAFNMDGGQTAVMVFMGKQLNQIGAYDGGKTNSRPTSEVLGFGTSEQVGTYEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGH9</accession>
    <name>R7IGH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000150">
        <property type="protein sequence ID" value="CDE49682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49682">
        <property type="protein sequence ID" value="CDE49682"/>
        <property type="gene ID" value="BN770_02087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="116"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="343" mass="38523" checksum="C54E5C0D4447C6D8" modified="2013-07-24" version="1">MEQFSEFFENLAFMTFSHDRFWVLCAIIVAVILVYQLLLRFAPKTVGPVHHFLQRHPLIWICIPAALLIYFVYVSLGWNLWVSVSDWESGQLEASYGWGGFGNYAKMFSSPDFWPSLRNTLLLFCLIPLCLLLGLGLALIMDQGLRGTALFRTLILLPFALSFVVTGTVWAYMYRPTGGVLNSFLSILGVDVSAAMKAGHLMWASSNSTIMLSIIIAMVWQFSGYVAVIFLAAIKNVPVNVINAAKLDGAYMPRIYFKLIIPQLKGAMGSCITILAMYALRSFDFIVSLVGYTTSAAWTLPIWMYNEAFQNNNFAYSAAISCFLLALVLVLILPLTYWTNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGX2</accession>
    <name>R7IGX2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="7" type="ORF">BN770_02446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50583">
        <property type="protein sequence ID" value="CDE50583"/>
        <property type="gene ID" value="BN770_02446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="63" mass="7241" checksum="C2842256F297C105" modified="2013-07-24" version="1">MKANEFTSMSKEQLTEKVAELKKDLFTLRFQLATGQLQNTMQITAVKRDIARAKTVLRQLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH46</accession>
    <name>R7IH46_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49907">
        <property type="protein sequence ID" value="CDE49907"/>
        <property type="gene ID" value="BN770_02183"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="201" mass="22516" checksum="B7C06B90D3FDA30A" modified="2013-07-24" version="1">MGQIRVEKNVGGITGLCVIEPAVHGDARGYFMETYNERDMKEAGIDVHFVQDNQSMSTKGVLRGLHFQKKYPQCKLVRVVRGTVFDVAVDLRADSETYGKWYGVTLSAENKKQFLIPEGFAHGFLVLSDEAEFCYKVSDFWHPNDEGGLAWNDPAIGIDWHVRGEYRGSASADGCTLADGTPLNLSEKDQQWLGLKDTFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH70</accession>
    <name>R7IH70_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49932">
        <property type="protein sequence ID" value="CDE49932"/>
        <property type="gene ID" value="BN770_02193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="75" mass="7786" checksum="385970175E3BFFB2" modified="2013-07-24" version="1">MQYSGGGVTIGNNVFIGGRSIILYDVNIGDNVIIGAGSVVTRDIPSGSVAVGCPAKVIGKFEDSVERYIAANRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHB5</accession>
    <name>R7IHB5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhamnulose-1-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rhaD</name>
        <name evidence="5" type="ORF">BN770_00224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:19689"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58313"/>
            <dbReference type="EC" id="4.1.2.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldolase class II family. RhaD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.19" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50831">
        <property type="protein sequence ID" value="CDE50831"/>
        <property type="gene ID" value="BN770_00224"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008994">
        <property type="term" value="F:rhamnulose-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00770">
        <property type="entry name" value="RhaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013447">
        <property type="entry name" value="Rhamnulose-1-P_Aldolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="4">
        <location>
            <begin position="10"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="275" mass="30665" checksum="078B7E119DE906B8" modified="2013-07-24" version="1">MSILDLDIIKGYIRMCTDGWNQGWHERNGGNLTYRMKDEEVAQCRPYFRATPGEWVNMGVQADNLAGEYFITTGSGKYFRNVELDPEHNMGIVEINDKGDSWRIVWGLEGGARPTSEFPSHFMNHSVRKAATNGANRVIYHCHATNVIAMTYILPLTDRDFSRALWQSATECPVVFPEGVGVCPWMVPGGAAIAMATSELMKHYQAAVWAQHGLFASGPDFDITFGLAHTIEKSAEIYIKVLSAGQGKIRQTITDDDLRAIAHDFGVTINENFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHC1</accession>
    <name>R7IHC1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fn3_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51020">
        <property type="protein sequence ID" value="CDE51020"/>
        <property type="gene ID" value="BN770_00265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1099"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1160"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="494"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1194" mass="128085" checksum="D25784D91FBC9420" modified="2013-07-24" version="1">MTIYAQKETSFDTNAFRVVFCDRISTSKGALRPHRKGKVSMKRTKLLALLTSISCILLTIVLVGSYFTAAYAMMINKELGIVTTSVVTDDPSKNATYYASSFLKEDGTRDDDALTAWQKALCEQIQGEGSVLLTNNGALPMEKGLGVTVFGRGAVDTIYGGTGSGQVDTSKAATMTSALTAAGLNVNTAMMDWYSAQIAQMKEDKTNRSTPGMFTEYADVPAATRIAEVSADAVASSGVNLDGYKDAAIVVIGRSGGEGADLYTGEFTDGTSYFELQDSERELLKYVASQGFSKTIVLINSSNAMAMDWVNNPEYGVDACLWIGGPGQYGLNAVAQILVGDVNPSGRLVDTYSVSSLSSAAIQNFGSYVYTNADEETGTVGSVTIDGVPGDKTKVRYAIHYLVESEGIYVGYKYYETRYEDAVMEQGNASGNAGIFASKGDSWVYGEEVAYPFGYGMSYTTFEQALESVTYDAATDSFTVLVKVTNTGDVAGKEVVQVYGQQPYTEFDRANAIEKASVQLVGFGKTNVLQPGESETVSVTVDRKELTVYDEHVNKTYILEAGDYYLSVGLDAHDAVNNILAAKGYAPIAQETPAAEGAEEAETATLTANGAAAMDAPGDAAKVYKFTVDSDDNATYSVSGTGYKITNQFGDADLNSYGEKLVTYLSRSDWQGTWPVSYASLTANDAIINGLQFNYTAEAPDETVITGSTATNYTLANLIGKDYDDPMWVDLLNQLTLTDLAELVGHSGYGTRAIDSIGLPATVAADGPQGIKATYAGNNSTVAYTSEPVMAATFNTEILYNVGLSMGEDALRSDNRVVGWYGPAMNIHRTPYSGRNFEYYSEDGFLSGKMAAQEVAAARSKGLVVYIKHFALNDFETYRQSVATFATEQAIREIYLKGFQYAVEEGGANAAMTSFNRIGTRWAGAHSGLCSEVLRKEWGFVGVTLTDAVMANRNWMDVSIGLEAGNDTWLSSGDWLVSKIEGWAAEDGKLLNNLRTSAKNFLYTYANSAAMNGMNETSHVVHTTSWVETDMLIARIVLIVLTALFGLAMLVSYFMDVKKKAASADRKTVSIVAAVIAVLAAIFYIIIDTAATTKMNFDAVVLVLLLVSAVCYLVAGVKKIGLLAAAGLACTLVAWFRYLVTEINFRMDDLVLIFGGTSTIGALGVPFILSFILMLLAVISGAVLMTGAMGPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHE4</accession>
    <name>R7IHE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51045">
        <property type="protein sequence ID" value="CDE51045"/>
        <property type="gene ID" value="BN770_00276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="35"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="360"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="597" mass="67824" checksum="183492A457A78499" modified="2013-07-24" version="1">MRSKFGDNEPQDVSYHGNAFLRLMGYIKPYWKTVALCCVLVGLLTVFDIARPRIIGDAIDKYITQQSAQDLPPETRFQGILIAAGLYVAILLLQFICNRLQYLKIQETGQNIVYTLRNELMAHVESLSMRFFDLTPVGRIVTRITNDTEAVNDLYANTIVRLFRNVVKIIGLAIIMMVMNFRMAMLSFVLVPVMAALTVVFRKLSRKTYQIVKTRITTLNTFLSEHLSGMRVIQIFAREKEKCAEFEEKNESLYRAGVREMMVFAIFRPSIYFLSVIAMAIILGGGSALVLDGVISIGMLYTFTEYISQLFTPVQELAEQFTTLQSAIASAEKIFTLLDEKPMLSDKEDAKKLPAVRGKIEFDHVWFAYDNVNWVLKDVSFTIEPGQKVAFVGATGAGKSSILNLIGRYYDVQKGSIRVDGVDVRDLTRDQLRAAIGQVQQDVFIFTGDIKSNIRLRDEEITDEQVHRAAEYTNASRFIERLPNGYDEHVTERGATFSAGQRQLLSFARTLAHDPKILILDEATANIDTETEQWIQEALERLMQGRTSIMVAHRLSTIQHADRIIVMHHGRIRESGTHQELLKQDGIYKKLYELQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHF7</accession>
    <name>R7IHF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000177">
        <property type="protein sequence ID" value="CDE50728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50728">
        <property type="protein sequence ID" value="CDE50728"/>
        <property type="gene ID" value="BN770_00192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="356" mass="38828" checksum="BC8886CA77CBBF6B" modified="2013-07-24" version="1">MKNQNAAIWCALLLIALPIAVLLLVPSPSARIVDVVQPLMESEEIDYWNPDIFFLTKYGLTAAISVLCGLVLTLLCSRKRLSLDTRAAICTVGGFGALVGARVLYMLARYSYIMVDLGGSSFFWQFWQGGYTLYGGILGGMGAIALYAKLTKQKALPLLDAVTPGALLALCGLRLAEGFTGQGFSKQMDDICWYFLPFQNEDGQMLVWAYEAIVAAVALVIVLVQGRRQKIAGRTLETGLTIISVMQVLLDSWRADELIRFGFVRLNMLMAALTLAVLLATRLTRCIRRDGLKGISIARIVMLLAGAGVCIAVEFALDKSAINNGILYGVMMLALVPMFIAVLLDDGRIQTAEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHQ2</accession>
    <name>R7IHQ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50833">
        <property type="protein sequence ID" value="CDE50833"/>
        <property type="gene ID" value="BN770_00225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="145" mass="16271" checksum="B5CEDA4537B61452" modified="2013-07-24" version="1">MNITIRKMQPGDADALYRLLSDPEVMRHLEPPFDREKAETFLHHAGLTEPPLVYAAEASGDFIGYVIYHAYDADSVEIGWVLLPEYWGRGYASALTDRLIDQALQERKSVVIECAPAQEATKRIASKKGFRDCGICDGLALYRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHY8</accession>
    <name>R7IHY8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51399">
        <property type="protein sequence ID" value="CDE51399"/>
        <property type="gene ID" value="BN770_00413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="345"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="589" mass="64468" checksum="972FB60CFE714525" modified="2013-07-24" version="1">MLRILKHLRWKEWLLVAACVVLIVGQVQLDLALPDYMSEITRLVQTEGSQMSDILLAGGKMLLCALGSMLLTVCTTFFTAQIASRFSARLRGEMYRKVVGFSNEEINRFSTASLITRTTNDISQLQMFFSFGMQSLIKAPIMAFIAVGKISTKSWEWSLLTGGVIAFVCVLLVFIMLYAVPRMKKMQALTDNLNRITRENLTGLQVVRAYNAENYQEGKFAKANEEMTRNSQQANIAMSVMNPGMNLAMNGLTLGIYWIGAALISAIAVTSPAAMMERIGLFSDMVVFMQYAMQVIMAFLMLVMIFVMLPRVTVSASRVNEVLDTKARIVDGKETQGKPGMKGEIEFRDVSFRYPDADGDAIHHISFTAHCGQTVALIGATGCGKSSIINLIPRLYDATSGQVLVDGVDVRDYTQDALRSKIGFVPQKAFLFSGTVSSNVGYGEDNASGAAIRKAVAIAQAAEFVESPEVGYSGTVAQGGSNFSGGQKQRLSIARAVARDPEILVFDDSFSALDYKTDHALRQALREQTSGTTNIIVAQRIGTIRDADCILVIEDGAIVGKGTHRELMESCKVYQEIAYSQLSKEELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHZ9</accession>
    <name>R7IHZ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50943">
        <property type="protein sequence ID" value="CDE50943"/>
        <property type="gene ID" value="BN770_00250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="213"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="315" mass="34837" checksum="8F20D1C318DBBD90" modified="2013-07-24" version="1">MIRKVVVAGGGVLGSQIAFQSAYCGFDVTIWLRSEGSIGRTQPKLDHLHQVYIDTINLMATPDGQTPANWANGIADFDGFDPKKCLEKVEAAYKNTHLELDMAKAVADADLVIESMAENVEDKISFYQKLAPLMPAKTVLVTNSSTLLPSKFAKYTGRPDEYLSLHFANSIWKNNIAEIMAQSKTDPKVFDTVMQFANDIRMIALPVRKEKSGYLLNSMLVPLLFSAMDLYVNGISDPESIDKAWTLGTGAPKGPFHILDTVGLTTAHNIVKMYLKIPSFLAPYNFKGMDKMLKEYIDAGKLGQSSGEGFFKYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7II71</accession>
    <name>R7II71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate--ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Asparagine synthetase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asnA</name>
        <name evidence="5" type="ORF">BN770_00266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine</text>
            <dbReference type="Rhea" id="RHEA:11372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51023">
        <property type="protein sequence ID" value="CDE51023"/>
        <property type="gene ID" value="BN770_00266"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00555">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="PTHR30073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001555">
        <property type="entry name" value="Asp_ammon_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00669">
        <property type="entry name" value="asnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="4">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="334" mass="37732" checksum="A75894A152F3A9A2" modified="2013-07-24" version="1">MHLIIPKNYNPVLNLRDTEIAIKLVKDFFETELARALNLTRVSAPIMVTPGSGLNDNLNGVERPVSFDVLETGETAEIVHSLAKWKRQALKTYGFQPGEGLYTDMNAIRRDETTDNIHSIFVDQWDWEKIITPKQRTMETLQATVRAIYLTLRKTEGFVCAHYPHIKPELPDDITFVSSQELEDLYPDLPPKEREYRAVREYGAVFLTGIGGALRSGQMHDGRAPDYDDWSLNGDILLYDPLLDIALEVSSMGIRVDPDALRRQLAIRGCEERAELPFQKALLNGELPQTMGGGIGQSRMCVYLLRKAHVGEVQASLWPQDVQEACRKANIQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7II96</accession>
    <name>R7II96_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000200">
        <property type="protein sequence ID" value="CDE51191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51191">
        <property type="protein sequence ID" value="CDE51191"/>
        <property type="gene ID" value="BN770_00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="382" mass="43202" checksum="4781F9BB261A474E" modified="2013-07-24" version="1">MSEQTPRRRRADRVYTPEENEAAPCRRRMNADEPPRRRRTREYYSPEEFIPYPAEDSFDTMPPDIPFDVPPDTPSAPPKRKFRLPPLGESLRRTMQLLRSARPDFPFRRPHGVGDLLNMLLDALLWVPKLIVHLTLYACRYLRASVRYAVEGATPLWQAFLLCPYSWAGFYLLLGGLAFSGVHLMSRGSTGASFAGFVLLLAPLAWGIVLGWAAANALHRHCFFSRWTFVALEVLCAIGIAGAALGYPSALLASAPLPLWMLAGALLLRRTTLQSFSPAAIVDFFQRLKPRWELRRIGLHTAATVSYTAPVKRNCFFIELQCTHPSTGNALILFHTSTIEPALGQKAHVILHPTEEDIYEVDLTTSIPRVKIRKNDLWRNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIA0</accession>
    <name>R7IIA0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nigerose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000188">
        <property type="protein sequence ID" value="CDE51048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51048">
        <property type="protein sequence ID" value="CDE51048"/>
        <property type="gene ID" value="BN770_00278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="280"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="314"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="558"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="700" mass="77365" checksum="20472C4A52A59CA5" modified="2013-07-24" version="1">MNTVIERTGFDPAQDADNGNRFLTGNGYMGVRGTIGEAGVQQMTAVNLAGIHHQKGQGWEEPLNAPNPLYVAVKGVSLPENADRLTSHRLALDIADGVFTRESTFKADAGEITIRQERFCAMERVHLLAQRVTITATHDSVVTIAFGVDENVWDIHGPHYETLTLTESDGVVALTGETDDHQRVCTALRCSCTDGEITHGGVRTAQIALRAGQPWQLDEVAAVYTTSDGDEPEASAIEAAENAPAYDALREEQRAAWAALWQKARVTIEGDERAEFAVNYSMYHLMSIAPRHRAALSVAARGLSGQTYKGAIFWDTEMFMLDFYLACMPEVARHCLEYRVQTLPGALDKAKSYGYAGAFYAWESVEGGKDACTDYNVTDVFTGRPMRTFFRDTQVHISAAVVYGLRKYTQYTGDDSLLQSGGARVVLECARFYMSLISKRILSDTYDLLDVMGPDEYHEHVKNNAYTNEMARMTLNYAVEVCQKYLPETDEAELMHFADAAKHLKHQAPDPKTGLIEQFDGYFKLENVLVPEVRSRLIDPREYWGGAYGVAAQTQVIKQADVIALLYMLGQYPADIIAANYDYYEPRTEHGSSLSACMYALCACAIGRPAAAYPLFLKSAEADIVGGGKQWAGLVYIGGTHPAAAGGAYMVLLYGFLGLRFEDGKPTLHPRLPEGWKKVQLQVHWQGKDWLLTAEEGQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIG2</accession>
    <name>R7IIG2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51415">
        <property type="protein sequence ID" value="CDE51415"/>
        <property type="gene ID" value="BN770_00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="317" mass="35141" checksum="B5C6928A34071758" modified="2013-07-24" version="1">MIELRHVTKRYGAVEALHDVSFRAPEGQIVGLLGQNGAGKSTTLNILTGYLPPTSGQVLVDGMDLLQNARECKRLIGYLPEKPPLYDEMTVRSYLRFVCELKEVQKSAIAAHVEDIIRTCGLSEVAHRLIGHLSKGYRQRVGVAQSLCGNPKVLVLDEPTVGLDPRQVVEIRALIADLGKTHTVIFSSHLLSEIQQLCQRVLILNRGHLEYEADMQELAETGETLRLRASIAMREKQLIPALRSLPCVRRVKALPTRTIEVSEVLLECDASAVPDAQTQLFRLLCGLDAPIRMLVEEHDSLETVFLRATDEGTKVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7III8</accession>
    <name>R7III8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine synthetase beta-grasp domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50407">
        <property type="protein sequence ID" value="CDE50407"/>
        <property type="gene ID" value="BN770_02372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="102"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="422" mass="46657" checksum="37C3F7DD8EC34DC1" modified="2013-07-24" version="1">MTEQEVLDFVEENDVKFIRLAFVDLFGTLKNISIMPTQLHRALSGSVSFDASAVKGFCDISHSELFLRPDPKTITLLPWRPQTGRVARMMCDCLLPDGTLFTGYSRSILRQQVEKAKSLGLTFQIGTEYEFYLFQSDDAGDVTLHPQDSAGYMDVSPLDKGENVRRDICLTLENMGIIPESSHHEHGPGQNEIDFQYAGALKAADNAMSFKTTVRTIANQYGLCASFLPKPLRDESGNGLHINLSIERGGINIFEQQDGQLSLDAQHAIAGILSRIREISLFLNPLPSSYQRLGCWEAPKRINWSFGNRSQLVRIPAAHPGAGRMELRSPDPACNPYLAFALVLAAAMEGITEVTPLQAPLDDSGSLPESLEEAISLAEKSAFIREVLPENVIDAYLAEKKKTAARFEADANAVFQQHLRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIL8</accession>
    <name>R7IIL8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50437">
        <property type="protein sequence ID" value="CDE50437"/>
        <property type="gene ID" value="BN770_02392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="434" mass="47019" checksum="EA8EDA82FD96324A" modified="2013-07-24" version="1">MRRLAAAALAAVLLLSTALGERVTFRLSADIDPVQYPAQERKLAQGLKSLFRLLTVEGDVVVSDGSFDARIDLGLTNAPEKTATRIRFFGLDSHWGIQATDLGGETLMVNQLAWLEFAIKAYNHLDLPLQRVFLWLSPYAHTSAWAGLRQEIADLAAQETSGRLENTALITCAEEIARLSEDDRALYYYIEAFGLESGTDANIFDALATLPEYVEANFPDGLSIEHTENGVSWQNGEKTVFSYADADGTQVVSLHLPDLVDFSATLRRDALLFTGALSLQSDVLNADVSFSLPASYPVTLPFYAQIDADGMMTGDDGIHLAFEGEAQGDTVIIRRIQPDHSATMMTLTVKVIQVAEGTVKYAPEDVQGTNVLSVDGPALAELMGRIGKPMVRKVTQWLAALPAELVQGAMDAMEDSGLLGTLTDAILNGEAGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJD9</accession>
    <name>R7IJD9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51596">
        <property type="protein sequence ID" value="CDE51596"/>
        <property type="gene ID" value="BN770_00511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448024" evidence="1">
        <location>
            <begin position="24"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="412" mass="44569" checksum="59CFA1C82267DFF4" modified="2013-07-24" version="1">MKRSARMAAFLLAAALSAAPCMAEFTPVEVPQATNAPAAPEAMENVPQITEKGLTLGNNSVKYPEITGMADENIQQQVNDAILQAGKIENRLSRMAVLMSSPVPLTVTYSAALADDVLSVAILSSGALETERATQEWAAVNIDLRTGQEITFGDLFTDEDEARAKMEETIADEILPDMSAHLAAAELLPLPDVFSLTEFGLTLHYPIRRFETLSERAGTITFLWSELADMLDLSEDSVLTRLGVGKHLMLAADAKETLTAALSGGAFPSIPVALGDNVQGLIDTYQLLNDPDLAGDQRMISLEDGAFRNVYILTDNLTRKLDSSVAQSIRADRLMLLGLVTGSTTQDEWRQALGEPTRTVSVSAESAELRRLCAGQTDYYAWWSNATLCLHADEDGVLRTVMLMQAENGGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJN6</accession>
    <name>R7IJN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51825">
        <property type="protein sequence ID" value="CDE51825"/>
        <property type="gene ID" value="BN770_00635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="224" mass="25742" checksum="5C3875990967F2DE" modified="2013-07-24" version="1">MGRLYRCLRAVVRAVTPRMTTTWEEPFSGNPSVFVCNHVGAFGPIDMVVKFPLRDEVRVWCNEGIMNRKTCPAYVRQDYWWKPGCRLEPLYNATLPYIAAAVLPPILQSAPTIPVYHDARVMTTMRQSMKALKEGKHLVIFPEQPSGFGEHHSWINTGWLNVCTMFYRATGKNLTLYPVHIDQKKHCFEVQKPVMFDGNRTLEEQQDELVKHLAAGLRGQHVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK07</accession>
    <name>R7IK07_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51648">
        <property type="protein sequence ID" value="CDE51648"/>
        <property type="gene ID" value="BN770_00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="415" mass="47194" checksum="DDD6615693E04D25" modified="2013-07-24" version="1">MIAQTPPMGWNSWDCYGAAVDEPTVRQNAAYMAEHLQVFGWEYVVVDIQWYQPTATSHAYEPFAELTMDEYGRLQPAPGRFPSSAGGKGFKPLADYVHSLGLKFGIHIMRGMPRMAAHRHLPILGCGKGCHEVANPNSICAWNPDMYGLRCDMPEARAYYDSIFRMYAEWGVDFVKCDDIAREYPHCKREIEVISDACRACGRNIVLSLSPGPAPLEQAEHLKKYANMWRITDDFWDEWRLLKGMFERAEKWCVHAAPGHWPDADMLPVGALRQCYDPNGWTNFTQAEQRTMMTLWCMMRSPLMMGGELTKNDDFTLKLLTNRDVLAIEKTSACAHPLWTTEDESVWIAPRRDGTGLYVALFNLSEETRTVRVTGEMLEGTYSEASELWTGEKLHLADGVTATLRKHDAAVFWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK14</accession>
    <name>R7IK14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51781">
        <property type="protein sequence ID" value="CDE51781"/>
        <property type="gene ID" value="BN770_00608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436008" evidence="1">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="141" mass="15240" checksum="25E197BA2973406F" modified="2013-07-24" version="1">MRHKGMTFCKLLVLLVLALLLTGCAQQPQAPFDGVIATSDVVFNLDFTALNTTYTSTLIVPEGKEIMADIQCDGGRIDVTITPEDGEPIYTGKRLPTSSFSIVPKTPGRYTVTISGENASGYAHVYVEGAVHYDDEPAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKH1</accession>
    <name>R7IKH1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51793">
        <property type="protein sequence ID" value="CDE51793"/>
        <property type="gene ID" value="BN770_00619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="260" mass="29482" checksum="D5BA03FC8613D7DC" modified="2013-07-24" version="1">MNQAYESASFVRCVVPETADIQAASAAVAANPESGDAWMKKGHALAKVSMMREAEECYAMAISCDPFNWEYYRHRAHRFLSCWRFEDAAADFVIASRLNPNDWNVFYHLGLSYFLLRDYAKAAKAYARCYELTDAEPELIAVTDWYYMTLKRLGNDEEAAKILARITDHMNPGENTAYYARLLMYKGLKKPEELLSTDPEEVTALELITMGFGIANYYLQNGDPDTAYALMERVVKAGDENDCYFAFAYLASKVDLTNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKI2</accession>
    <name>R7IKI2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dak1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000247">
        <property type="protein sequence ID" value="CDE51803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51803">
        <property type="protein sequence ID" value="CDE51803"/>
        <property type="gene ID" value="BN770_00621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dak1_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="86" mass="9945" checksum="C8703A626BA30CDA" modified="2013-07-24" version="1">MAEMLEFKFDTQLLIEGHDLDEDEINDYITEHFKGDCLLAVGDDELIKIHFHTNEPWKVLEYCASLGEIHDIVVENMQLQSEGQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKK2</accession>
    <name>R7IKK2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51828">
        <property type="protein sequence ID" value="CDE51828"/>
        <property type="gene ID" value="BN770_00638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="26533" checksum="42B3EA5BB83BD015" modified="2013-07-24" version="1">MHRFYADGLGEIGSLVTLSEEDARHASRVLRMQPGDAAELFLDGRRFSAEIAEMTAEGVTARLISELPSTEATLRITLYQGLPKAEKMELIVQKAVELGAARVVPVAMSRCVVQLSAKDGAKKQERWQKIAREACKQSGRCQMMAVDAPIAFPALLTALKTHEAAIVPWEDARGHSLTAFHREHPEIRDLAVVIGPEGGMSADEIARMKDCGCQSVTLGARILRTETAGLCALSALFCLYGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKQ7</accession>
    <name>R7IKQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51888">
        <property type="protein sequence ID" value="CDE51888"/>
        <property type="gene ID" value="BN770_00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="302"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="512" mass="57670" checksum="8A34D6E8B6A9A69C" modified="2013-07-24" version="1">MMEKNLYPEIPKEKFAFIHKDERIHDEKLQTKSISYLGDAWLRFRKNKSSVVAFCLIVFLLLFAIITPFVSPYTVQFRDGYYKSVLPKNTLFENAGFWDGARKEKVSEIGYHYYNAIGQETGVPVVKKEYDHYTDSNGVTYYNLRVDSYALVGFAYVNLSETEYNNLMAYQNEKDIQVIYPLQKTHNSQYMMGNGGANFWYQLKDESVNTNGDPALDENGSLIPNYLTSDNPNKANYNSKRIAGDDGADGQWYTYAQKNQTGYRVRVHYLEYFRYVNGYEPTFIFGTNNYGQDIFTCLAVGARLSFLLSIVVASINFILGVLYGSIEGYYGGAVDMVMERISDVLNSVPFMVVATLFQLHLAEKVGVLPSLLFAFVLTGWVGTAARVRTQFYRFKGQEYVLAARTLGASDARLIFKHIFPNSLGTIVTGAVMTIPGVIFSESMLSYLHIINLETSSLTSIGTLLSGGQAYLSTYPHIIMFPAIFIAILEIAFNLFGNGLRDALNPSLRGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMW4</accession>
    <name>R7IMW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC superfamily ATP binding cassette transporter ABC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51972">
        <property type="protein sequence ID" value="CDE51972"/>
        <property type="gene ID" value="BN770_00725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="245" mass="26955" checksum="E133B02429379AF3" modified="2013-07-24" version="1">MIDFDHVVKQYGKSSVRAVDDLTLHVGKGQLFGFIGPNGAGKTTTIRLLTGILQPTSGSVTIGGVSMKDDPIAAKRMIGFVPDSHELYDRLTGMEYLNFMADVYGVGAQERKAHIEKYLALFELENAAGEQIKSYSRGMKQKLTIIGALVHQPPVWVLDEPMVGLDPRAAHILKEEMRKHCEKGNTVFFSTHVLEVAEKLCDEIAIIDKGRLVAQGTLEALRSGEKGASLEQLFLELTESEEKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3V3</accession>
    <name>R7I3V3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000003">
        <property type="protein sequence ID" value="CDE46161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46161">
        <property type="protein sequence ID" value="CDE46161"/>
        <property type="gene ID" value="BN770_00757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12831" checksum="046721680C7126FB" modified="2013-07-24" version="1">MKEILRTTIRLYAEKPADQEALRLLRQVREEQHLRYADAIVAAVNAHYGQARQGCFDHQQREEIRGIVREEMAASSASVFNLLRCAGQTPAETSEDANAPDETDLDNLLDMMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3X5</accession>
    <name>R7I3X5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000020">
        <property type="protein sequence ID" value="CDE46599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46599">
        <property type="protein sequence ID" value="CDE46599"/>
        <property type="gene ID" value="BN770_00959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01046">
        <property type="entry name" value="Rubrerythrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045236">
        <property type="entry name" value="Rubrerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="50"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="180" mass="19869" checksum="BC6D4C00A7886430" modified="2013-07-24" version="1">MKWVCSVCGYVYEGEKAPEQCPVCKAPASKFIKQEAEMAWAAEHVVGVAKGAPEEIIQGLRENFQGECTEVGMYLAMARVAHREGYPEIGLYWEKAAFEEAEHAAKFAEMLGEVVTDSTKKNLQMRVEAENGATMGKTELAKLAKALNLDAIHDTVHEMARDEARHGKAFAGLLKRYFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4H2</accession>
    <name>R7I4H2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000003">
        <property type="protein sequence ID" value="CDE46163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46163">
        <property type="protein sequence ID" value="CDE46163"/>
        <property type="gene ID" value="BN770_00759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="459" mass="53498" checksum="2D45E3381491F627" modified="2013-07-24" version="1">MILDEWKSAQRQRVIRYAHFDRRISLEQCWKYISSPESVAIHAFMPFIHYTITTRKVKNGKKQPPKKREIFYAAHKDAWIYRYYSYLLNEQYNARVQQDGIDSVAVAYRNNFKGRNNIDFANDAFRFIQSCRSCCVMIGDFTSFFDNISHPYLKKELCDLLNVECLPPDYYAIFKSVTRFSYAEMNDLLDYYKLEKNKNGQKQLNQRDKLLDTKTIRAWKKVFKKNPNLPEAKGVPQGSPISAVLANVYMLKADKQIYEYVSALQGFYMRYSDDFMVVIPNTAPVDFRKHYETICGFITEAGGIEIKAEKTRIFSVENGVIRNCIADVILGQENGKNLIDFLGFSFDGKKIRLREKTISKYYNRMHRKAVTIFKCSGVTKKGNRINANELYKKYSYKGSAAYQNRKAAINGGKHIEGNLFDYLKASKRIIGDNFVDSITPRHMARIRRFINGKQGKHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4L4</accession>
    <name>R7I4L4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46585">
        <property type="protein sequence ID" value="CDE46585"/>
        <property type="gene ID" value="BN770_00952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="333" mass="37501" checksum="977FC1541A75FC58" modified="2013-07-24" version="1">MIELKDIVVKFGDFEALHNINVNVKEGEFFTFLGPSGCGKTTTLRTITGFIEPVSGTVSVNEQDITHVPIEKRNIGIVFQSYALFPTMTVYDNIAFGLKLKKLKKPEIDQKVREIARKVDLSDEQLKKAVSQLSGGQQQRVAIARALVTGPSIICMDEPLSNLDAKLRVQLRNELKKMQREFGITTIYVTHDQEEALTLSDRIAVFNKGYIEQIGTPNEIYNHSKTEFVCNFIGDINRVEAPIAAKMKLAAGQNHFIRLERLHVNKPKRDDEILIDGVVENIEYYGLYIKYYIDVGSQILKAIEKNDGINIYAPGEKVTVAMKPTDVMSYDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4R6</accession>
    <name>R7I4R6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Elongation factor Tu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000021">
        <property type="protein sequence ID" value="CDE46635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46635">
        <property type="protein sequence ID" value="CDE46635"/>
        <property type="gene ID" value="BN770_00968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="10"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="237" mass="26155" checksum="6036435C2C380AF8" modified="2013-07-24" version="1">MAKERYERKKPHVNIGTIGHVDHGKTTLTAAITMTLSQKGEAQAMRYDEIDKAPEEKARGITINTAHVEYETATRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAPDGPMPQTREHILLARQVGVPYIVVFMNKTDMMDDEELLELVEMEIRELLSSYDFPGDEIPIIKGSALKALEYVQNGGTDVDHAPECQCIWALMDQGFCPEGAGICPERRHRRGQRAGVQVHLGTDGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Y6</accession>
    <name>R7I4Y6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46556">
        <property type="protein sequence ID" value="CDE46556"/>
        <property type="gene ID" value="BN770_00932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="248" mass="28934" checksum="9D616F26FBCB9BAE" modified="2013-07-24" version="1">MQTYYTKWYSPSVGREMEIKVYGHAGRPVLFIPCQDGRFFDFENYRMTDAWAPWIESGQCMVFSIDTLDKETYSASYDPHDRIRRHEAWMNYIVREVAPFIQSMTNDRNGWDGTPGIIAFGCSLGATHAANLYFRFPETFDGLLALSGIYTSEYGFPGYMDELVYANSPVDYLAGISPDHPFIRLYNDHKAVVVVGQGAWEVPESTFRLRDICAQKDIHVWFDIWGYDVKHDWDWWYQQVAYHVPHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I548</accession>
    <name>R7I548_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47009">
        <property type="protein sequence ID" value="CDE47009"/>
        <property type="gene ID" value="BN770_01105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="261" mass="29417" checksum="D8066F111530DA2E" modified="2013-07-24" version="1">MAFTVHAVMPGVWHIVDCMGVCMTLLEGENAAMLVDTGYGIEDVADFMRHMTDLPLTVFLTHNHHDHAMGARCFPETYMLEADMADWDMFTNDKMRRRVLTQAIGKNLTVDEKTFLAGEIPLPKVMKPGAIDLGGLTAEIIEAPGHTPGSAVVYVPERKLLLSGDDWNPCTWLFFPQALGLREYRSNMRGIQQLPFEKVLCPHREALYDRWMFDDFFNALTDGNLRAAEPVNIAPYEQIDTCQATLPHDQVLVFDWAKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I580</accession>
    <name>R7I580_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46651">
        <property type="protein sequence ID" value="CDE46651"/>
        <property type="gene ID" value="BN770_00971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="447" mass="48760" checksum="E31C3524DC5B06B7" modified="2013-07-24" version="1">MKKNDLLTLTADGLGADLEGVCRADGMAVFVPGMLPGETARVRIVKVQSRFAFGRMEGKPLTASPARKAPDCAAYPRCGGCTGRHMTYETTLEAKRQQVQDCFRRIGHIDIDVPPVLGMADPSHYRNKTALPVGGTVEEPVAGFFAPRSHDIIPIAQCPNAMPPADEICRRVLGWMKRFHVEPYVEETHTGLVRHIVVRVNRKGEAMAVLVINGGEIPHEAELVASLKAAGAVSVILNENRERTNVIMGRHFRTLYGCDTLTDELCGLRFEISPAAFFQVNPAQTEVLYQTALDFAELTGDERLCDVYCGAGTITLMMARHCREALGIEIVPQAIENAKENAVRNGIGNVNFRCGAAEALLPKLVAEGLRPDVIVIDPPRKGVEPAVIDAIAQAAPKRVVYVSCNVATQARDAALFREKGYQVQKVQSVDMFCWTSGVENVMGLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5D4</accession>
    <name>R7I5D4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma factor sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46835">
        <property type="protein sequence ID" value="CDE46835"/>
        <property type="gene ID" value="BN770_01043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="158" mass="18407" checksum="6CE92D0359B9C480" modified="2013-07-24" version="1">MDARTFQTEALKIEKLLYHISYAMLRNESDCEDAVQEALLRAWQKRGTLRDMAAFRSWLCRIVANTCTELLRRKQRTTLTDIPEEMPAPQSDAIDHMAVMDALAELTPQMRVCMTLHYLDGWRVPEIAQMLDIPEGTVKTRLMHARKRMETLLREVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5D5</accession>
    <name>R7I5D5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTPase Obg</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">obg</name>
        <name evidence="11" type="ORF">BN770_01145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47089">
        <property type="protein sequence ID" value="CDE47089"/>
        <property type="gene ID" value="BN770_01145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="161"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="338"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="167"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="313"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="424" mass="45942" checksum="104B66C1168FF2C2" modified="2013-07-24" version="1">MGNFVDHVKITCKAGNGGNGSMSFHREKFVLNGGTDGGDGGNGGNVCFYADLNMHTLLDFRFKSKYTAENGVDGAAGNCTGKRGEDLIIKVPVGTVIREAESGAVVADMDTAGETRTILHGGRGGWGNRHFATPTRQAPNFAKPGIKTEVHTFLLELKTIADVGLVGYPNVGKSTILSVVTSAKPKIGNYHFTTLTPNLGIVRRHGKDIVLADIPGLIEGAADGAGLGHDFLRHVERTRLLLHVLDIAGSEGRDPVEDFDQINHELANYGELAERPQIVVCNKSDLPDSEENVARLKAHLAELGLDYPVFVVSAATHQGFDALLDKTGDMLEALPPIVHFEEEVSYDDSVKPGTFEVVRDGAVFEVVGSSMQRLIDSVNFDDEESMSWFHRTLRKWGVIDALRKAGAQEGDTVRIIDMEFDFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5L0</accession>
    <name>R7I5L0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46935">
        <property type="protein sequence ID" value="CDE46935"/>
        <property type="gene ID" value="BN770_01081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="52" mass="6234" checksum="8A14D1286FDAF0F6" modified="2013-07-24" version="1">MCKEIFAFRRVTPFSDFSLAERLIGDTISWEEISRQRLQNANQENQEEQHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5N6</accession>
    <name>R7I5N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46960">
        <property type="protein sequence ID" value="CDE46960"/>
        <property type="gene ID" value="BN770_01086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="512" mass="57075" checksum="DB813C2B4C6569DF" modified="2013-07-24" version="1">MRAIAWLIVKLSGLFVKLYHLILNAIRRFDRAMRKRYRPKHLALMVVLVIAITASITLFVPPYLGLSNDGSFAAVLADTGLSRLDPSDTSAFFNYYERVYNVGSSALPTGTTPLVQRMLVRTAVVIDELVTHDGLFDMRFLAAIYLLIYILLLIPMLSKLLGRVKVYSEGLFIAVFAVLIFGDTAMITRFASFYTQPIELILMVALANCVLQIPDSLNRFLPQIGLAGTVILMMAVNQYCALMGIVFSVAYWMLMRHKADALHKGLYLLLAVLLCVVSVMQTGDMVNNQTINEKYDQMTRGVLFEATDPEKALAQFGIEARYSVLTDTYSTQSYPVVLPESGALDEGFLDQYTTADVTLYYLRHPIQLLGLFEVGVRNAFFTRTDYSGNYEQSSGMPARAKALFLSIWSTFKERSAPQTAASLLLLVVAFLFFRRKADEKLESGREAASVYTMLSVLLFAAVTVELMTVVILSGDSLLLRQSFLMGCLIDLLAIMACTEGLHRLKIIETDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Y8</accession>
    <name>R7I5Y8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47070">
        <property type="protein sequence ID" value="CDE47070"/>
        <property type="gene ID" value="BN770_01126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435445" evidence="1">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="188" mass="20742" checksum="738A7B108EC42F4B" modified="2013-07-24" version="1">MKRLISLLCALCLLFSFAFAEDYAATNPYTIENIGMTIDLPEALNVTSCEVGETSIDLRLGYNGRNDVSYAVMITYDESLEDYVTITLPEENLQAMIDYYQSMYTGGNPGLVAYDEDDGDAVLTPFCAGGQGEDGNMYCIFVCVLYGYTITVVGGTSADSFDDDTYGAAFDLYWTTITSFVDYMIENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I633</accession>
    <name>R7I633_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46703">
        <property type="protein sequence ID" value="CDE46703"/>
        <property type="gene ID" value="BN770_01003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="263" mass="30290" checksum="A35C8C4664DF514D" modified="2013-07-24" version="1">MANRVSQWFRKLSGHHAHHHHRKMTREDFQKLPRHVAIIMDGNGRWAKQHRLNVAMGHRQGTETLREIIRHTDDLKIEALSIYAFSTENWKRSKEEVGALMQLILDFFASEIDELDEKNVRILILGDKAALPEKQRDTLIEAERRTAKNTGLHLNIALNYGGRAELTRAARLIAEEAAQGRLNPDEISEETVAQRLYTAGQPDVDLMIRTSGEMRLSNFLLWQCAYAEFEFPTVLWPDFTVADYDEALAAFGGRERRFGKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7I640</accession>
    <name>R7I640_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">BN770_01007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46708">
        <property type="protein sequence ID" value="CDE46708"/>
        <property type="gene ID" value="BN770_01007"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="353" mass="37307" checksum="FAA55FD061B594E3" modified="2013-07-24" version="1">MYETRMVRVGNLTLGGHNPVWVQSMTNTDTRDAQATLGQIRALAKAGCDIVRVSVYDEDCARAVRTLVDGSPVPLVADIHFNHRLAIAAAENGIHKLRINPGNIGGEAHVRELAAAAKAHHIPIRIGVNTGSIEKDILAKYGQPCAEGLVESALNHARMLEKVGFEDIVLSMKASDVRLTIAAYELAAKRCDYPLHVGVTEAGLPGQGTIKSAIGIGALLAEGIGNTIRVSLTGDPVPEAKAAWDILRALNLRTHGVQLVSCPTCGRTCIDVAGIAARVEKELSDIQVPLKVAVMGCVVNGPGEAREADIGMAGGKRGGVLFVKGQEPMVVEENLADRLIELARKIAAEKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6C5</accession>
    <name>R7I6C5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma-24 subunit ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000046">
        <property type="protein sequence ID" value="CDE47414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47414">
        <property type="protein sequence ID" value="CDE47414"/>
        <property type="gene ID" value="BN770_00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="224" mass="25888" checksum="1050FFB9C1D44C39" modified="2013-07-24" version="1">MTALYAIPIGFVKHKFAFFSEKICLNLAESDMRMLYWKQMQEKQHPKGGMRVAQADDERQFLAACYQRHRISMIRLAKCYAADSAAVEDIVSDSLVALMEKIDLLRTLTEEQERAYVLAVVRNTAMDELRRKQRQRGRFLRDGDEALALYPDPTALEEKVLMRETMAAVRRAIAELPEKEQQVLRLKVLENRTDAEIAAETGLSPGSIRQYLHRARGRLREKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6V1</accession>
    <name>R7I6V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000030">
        <property type="protein sequence ID" value="CDE46998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46998">
        <property type="protein sequence ID" value="CDE46998"/>
        <property type="gene ID" value="BN770_01099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436213" evidence="1">
        <location>
            <begin position="24"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="469" mass="51343" checksum="EDA7A759B3441813" modified="2013-07-24" version="1">MRKLHSLISLLLVLLMLAPCALADAPLLQAASDWNLADTPLSVTLSISLQAHAPFDETRTAMLDRVLAPLSLNLYAADGESGVSVLMNGNELLTMAQKGDAVQFSCMPNVSYASQEGNALELLLGTSLNSIDLRAVDGTFEKWIDDGWVLSNAILEPFAEYGKRKSVKTSIKDMGLARSCTDYTFSKSKLEEMQQTLLSLCPEGDLHDLIASLTFSGTQKLRVYRTEDEVPLRVEYNGVCGVDGKLRTVKLVWRTKRESGETRDEITLTSPAKSGTDKNTLDFERIMTFSSGKITMQGTCSYKVTASKQTTQTEVTFDLTNRLENDSDNVSGSVAIKQQLPDEDYATKRTITPNVVLSGNAEAPEISGTIGYQEEKRYGTTEECVITLRAARASESLWKDTAATMELSTLSAETLQNLRSQLSGAIATAIVRPLIQVLSAEDAAFFFYEMSDEDVQTIRQAAESAVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7I721</accession>
    <name>R7I721_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 8 11">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pgk</name>
        <name evidence="13" type="ORF">BN770_01179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 11">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 8 11"/>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47251">
        <property type="protein sequence ID" value="CDE47251"/>
        <property type="gene ID" value="BN770_01179"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <begin position="356"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE47251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="400" mass="42192" checksum="728DAD0DE1342E22" modified="2013-07-24" version="1">MAKKTIDDIKVSGKKVLVRCDFNVPMKDGKITNDKRIVAALPTIKKLIADGGKVILCSHLGKPKNGPEEKFSLAPVAVRLSELLGQPVVFANDDTVVGENAKAAVAAMKDGDVVLLQNTRFRKEETKNVEEFSKELASLADCYVDDAFGSCHRAHCSTEGVTKFLSPCVAGYLIGKELAVMGKALENADRPFVAVLGGAKIEDKLNVINNLLEKVDTLIIGGGMAFTFLKAKGYEIGKSLLDETKIDYCKDMMAKAAEKGVQLLLPVDTVCIKDFPNPIDAPVDTVTVDADAIPADMEGCDIGPKSRELFAAAVKSAKTVVWNGPMGVFENPTLAAGTLAVAQAMADSDAVTIIGGGDSAAAVEQMGLGDKMTHISTGGGASLEYLEGKTLPGVACLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7B4</accession>
    <name>R7I7B4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000038">
        <property type="protein sequence ID" value="CDE47173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47173">
        <property type="protein sequence ID" value="CDE47173"/>
        <property type="gene ID" value="BN770_01165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="435"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="555" mass="58295" checksum="EC8F321077B70C74" modified="2013-07-24" version="1">MLKKYITDLKHEFSGYNAGKLLKDILSGITVAAVALPLALAFGVSSGADAAAGLVTAIIGGLVIGLLGGASFQISGPTGAMSAILIGIVAQYGLQGVFVASLAAGVIILLAGIFRLGKLVNFIPTSVVMGFTSGIAIIIALGQVDNFFGTHSVGTSALEKLWSYTSVGFTPNWQAVAIGLMVVLFMVFWPKKLNAKVPGSLLAIILATIVTEIAGFDSLAKVGDIPKSLMLDNRLNLGAVNLDMLQNLVSPIVSIAMLGMIESLLCGASASRMKDEAFDADRELIAQGVGNILLPFFGGVPATAAIARTSVAIKSGEQTRVTGIVHSLVLLLAMVLLGGVMSRLPLSALAGVLMVTAWRMNEWHGIKTIFSRKVWTGVAQFLITMVSTVVFDLTVAIVIGIVTALLMFVWNAARLTIETETVDKVRLERLHRMGKPVDESRAKSILVSYVNGSLFFANCAELKRKLLSVDFTGCEHLILSLRGVSATDISGVQTLMEVCALIAQKGVTVSICGVHENVAGFFQKVGLTDQLGAAAFYPNASEAVIDTLAQEQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7G2</accession>
    <name>R7I7G2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46462">
        <property type="protein sequence ID" value="CDE46462"/>
        <property type="gene ID" value="BN770_00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="178" mass="19480" checksum="75CCF2AC178638C7" modified="2013-07-24" version="1">MEAARTEQRGAIQWVKEHKTVLIAIGVGAIGIFFVAKNWNSIKGLFKASESAPCAIEKAATAVKETVVPTIPKDVLDNLTGNKLTARALGDKMGCTAQEINKRICTAGLAVKHPCGGYIMTEAGRLLGEETVKTTKYDYTFSNIEWDEKILELLFSKEELLEHAAKEEKIRQIIAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7T2</accession>
    <name>R7I7T2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47919">
        <property type="protein sequence ID" value="CDE47919"/>
        <property type="gene ID" value="BN770_01432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010368">
        <property type="entry name" value="Com_YlbF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06133">
        <property type="entry name" value="Com_YlbF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="SSF158622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="128" mass="14433" checksum="52834D6BEC41CB1D" modified="2013-07-24" version="1">MEHATAHRLAQEIRQSEEYQTYHALKEEVMAGEKTAAPLKEEQKAQFKPPAALLKEYKKLQLRLQMAAVSGTQPDNDDMQRFQGISALLFGKLEVSQYLLAEMRLQQEVAGILRIITDAADIDMGMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Z5</accession>
    <name>R7I7Z5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(d)CMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47398">
        <property type="protein sequence ID" value="CDE47398"/>
        <property type="gene ID" value="BN770_01243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="4">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="202" mass="22523" checksum="28C669B1337DCD71" modified="2013-07-24" version="1">MQPDFSRDARIAPILTRIAQLPKKPRLLVTIDGPCGSGKSTLADALSAALNAPIIRMDDFFLPHALKTPQRLAIPGGNVDLERLMQEVIIPFAAGQPVVYRRYLCREDAFSAPIPLPDAPITILEGSYSLLPDIRRHADLTLFLQINPEVQQERLLQRVGAARLKDFNARWIPLENAYFDAYHLPDESCVLVPQDVNAPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I852</accession>
    <name>R7I852_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47468">
        <property type="protein sequence ID" value="CDE47468"/>
        <property type="gene ID" value="BN770_01269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="165"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="427" mass="48057" checksum="8B15EFCC974CC759" modified="2013-07-24" version="1">MSAIHEHVLQNGMTLLCWPQRHLHGLEFGLYLKGGPLYETEETQGISNLLEHLCFRGLGGLNREGLLRELNRFGTNLDAATYAEGLVFRLKCLPRFFDAALEYFLRFFANVPWTPEQIAAEKQVVLRQLEADGDGDLFDRAACDFRKTENGAFPPLGTPESLMALTEADIQLWQEMIFQPQNACLVMTGNFSDGMELAAIEALSELRNTTAQPPFTQSLPIGFCMRDEQSDLLEEVESDFASVQLAFDVDSEQVYPVAAEVLSTITAGNDDSMLFQALREEQALVAEIESQISRVGQFSRLVIRYDVRSEWLKDTLTKVFAYLHRLTMYVRPARLNQLRTQFTTNNAMLTDDTAALNDRLGWAWMSGDTAQADLDAAAAQYNELTAEELLDAAQTVFRPENLSIAVQYDPEAVGDLRPMLQKLREML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8P3</accession>
    <name>R7I8P3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47985">
        <property type="protein sequence ID" value="CDE47985"/>
        <property type="gene ID" value="BN770_01472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="148" mass="16612" checksum="FFA62633C8569836" modified="2013-07-24" version="1">MRTHSPNETRELAKRLAKELRRGDVLLLWGDLGAGKSEFTRGLAQGLGVTATVTSPSFTILNVYDDGRIPLYHFDWYRLNSVEELYEMGMEEFLGGDGVAVVEWPSQCPEAIPETHLAIRLTPVDETTRDVTITPMGGFREISLEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8S9</accession>
    <name>R7I8S9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48020">
        <property type="protein sequence ID" value="CDE48020"/>
        <property type="gene ID" value="BN770_01496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448082" evidence="1">
        <location>
            <begin position="22"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="523" mass="57790" checksum="A991FC07ABE689C2" modified="2013-07-24" version="1">MKKLLAILLTLAMLVPMCGFAEESAPGATRTVIFLKDFNAKVLGADIDEAEEKAVNDFLDALRVIVYQQGTTSAAYEVTLNDQPIVDYAVQFSGADVYVSSDLLGETLYLNLDEDMQHFGELVYRQQLSQRGLTAEVINETVSSGYYAEQIAQVGQMGAMTAKVLKNPLFTENVQAEEVLNSLVAIDFTEMQRRLAEYQPSMTIDPVTEQLEGCDPVIQVCTFTLTNEQLVNRLAILLETAMQVPVVQNFADLAADYDNLMQFMSQTTTEEYVPQEIDWAAQVRQQTMLYSDAQVTLYTDAQGQLVKLIVNYSALPDWAERMSEVEPTEGILKPVTFTLNRNTLADGLQYDWTLEKEENSTTGRLTIGEKNAELVLMPDDQTQTTISLTVEPNRRGGRVDVEVRTTSEANGTDSGIQFGVFTSGSSSSVYRESRIRLLSGGEVGLTIYTTTFSCKPRPLLSDGDVLDLGEISSARFNAYMLTLATSISQILPRILMNLPNSVRQLMDGTTTLPSSTIILDNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Y1</accession>
    <name>R7I8Y1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48070">
        <property type="protein sequence ID" value="CDE48070"/>
        <property type="gene ID" value="BN770_01526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="308" mass="34316" checksum="EA9ED1BF9A920964" modified="2013-07-24" version="1">MATTTTFNGKKVHQGMIKSQKTRVGDFIIAFIIFLTMLICLLPMVNVLASSLSSSEHLIRNDVFLWPKGWNFEAYKTILSDSKYTWSLAWTGILTVVCTVLSLVLTVCTAFPLIYKNLRGGKVINFIILFTMYFSAGTIPGYILLNNLKMLNTPWALILPNCISVFNVIVLRSFFYSVPDSLREAAEIDGAGPIRTLVTVYLPLSLPSLATLALFYAVGRWNGFSDALMYLKSSKAEKYWPIQLLLYNIIKNSTQSSEIATQEGFFSAGVSKTIQMASVMFATVPILLVYPWLQRYFVTGVTIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Y7</accession>
    <name>R7I8Y7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48329">
        <property type="protein sequence ID" value="CDE48329"/>
        <property type="gene ID" value="BN770_01653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="163" mass="18483" checksum="E20944C277FBB00F" modified="2013-07-24" version="1">MSTYWINVPSGQTVHLRSEAETNTSNVITELPRGYPVTRVFSLDPFKYVSVWDCIDTIEGYVHQNYLTGVPSTCASDEMYIPRYSTPAWKRSSHSGKYYLPVKRIQSDLYDLGYTDVGTPDGYYGKNTETAVKAFQKDNNLTVDGIFGKKSKLALWELADRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I915</accession>
    <name>R7I915_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47743">
        <property type="protein sequence ID" value="CDE47743"/>
        <property type="gene ID" value="BN770_01330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="35542" checksum="C059B251C336C43F" modified="2013-07-24" version="1">MTGLAHAKKRQSWLHGLAISLKRDWRLYLMMILPVIFYIMFRYTPMHGIVIAFQNYNLFKGIAGSQFVGMANFEFVFKMRDFSIALQNTLLLNFLDLIVGFPVPIILSITLNEIKSTGIKRVSQTLLYLPHFLSWVIIGGMVLTIFAPTTGVVNSTLMKMNLISNNIPFLTNGVYWRVTYVLVGVWQSMGWGTILYMAAITGINQELFEAAKIDGANKMQQIWHVTLPGIRSTIVVLLILNVGQMMNIGFDRPFVIGNTMVQDYCDVISTFVYRAGIKNAQFARATAIGLFQSVVGLVMITTANFVSRRLGEEGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9F5</accession>
    <name>R7I9F5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47913">
        <property type="protein sequence ID" value="CDE47913"/>
        <property type="gene ID" value="BN770_01426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="229" mass="26888" checksum="47308FCF6B1899EE" modified="2013-07-24" version="1">MAAIPFQPMMESRPIREIAYEVLKHAIITGEIPAGERIVETEYADRLHISRTPLREALRKLERDGLVEYVQRRGVIVRAFTIADVEEIYTIRNALEMLTLPAIIQKATADDIAALRDRLHEMDGVMASRDFETLSPMARAFHRQMTEICGQNRILRVIEGQDQYITRFSSMAISQENRLLQAHEEHYKLVDYIEQRDLEHFQKLMHRHIERSKEKCLEALKTQRYLQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9L3</accession>
    <name>R7I9L3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47983">
        <property type="protein sequence ID" value="CDE47983"/>
        <property type="gene ID" value="BN770_01471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025720">
        <property type="entry name" value="RibU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38438">
        <property type="entry name" value="PTHR38438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037778">
        <property type="entry name" value="UCP037778_transp_RibU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="199" mass="22231" checksum="260D7014F0925B28" modified="2013-07-24" version="1">MTKQKTRSNLSVQYMTRIAILGALSAVLFPMEIPIVAFYKLDFSTLPALLGAFSMGPLPGLAILLIKDLSRLAYSSSMYVGELADFIMSAAFILPASLIYRKHKTRKTALVGMAVGTLCMIVVSVLVNWKMMIPFYMTAFNMDMEAIIGMAQKALPFVDTEWKVLLYVTAPFNLLKGFVLSLLTFVLYKRLSPMLHVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9U8</accession>
    <name>R7I9U8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000101">
        <property type="protein sequence ID" value="CDE48375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48375">
        <property type="protein sequence ID" value="CDE48375"/>
        <property type="gene ID" value="BN770_00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447721" evidence="1">
        <location>
            <begin position="25"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="228" mass="25324" checksum="64C0567BD2C4DFD9" modified="2013-07-24" version="1">MNHCKQTVFLILLMLVLLLPLASAEGRTFITVDDCVPLEIRAGSAVTAEELIVPKWGNVINPQFGDQIHPSLTNGDTVVQGDISSLRVLLLLADADGNKYLQAAVWDADSATYAITRSSNLPENAYLDTYHDGDAIFLSVGYDTPGFAESGDLDDLAWLYITAEWTDTDVWVVTDVTDGFSFFVDYDDGQYVIRDYWDEDVLQTISRDATLDTFDFVNPFAAEIGWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9W6</accession>
    <name>R7I9W6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxaloacetate decarboxylase gamma chain</fullName>
            <ecNumber evidence="5">7.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:57724"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="EC" id="7.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OadG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48395">
        <property type="protein sequence ID" value="CDE48395"/>
        <property type="gene ID" value="BN770_01683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015451">
        <property type="term" value="F:decarboxylation-driven active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005899">
        <property type="entry name" value="Na_pump_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04277">
        <property type="entry name" value="OAD_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01195">
        <property type="entry name" value="oadG_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="129" mass="13599" checksum="FFD607300F6BFE16" modified="2013-07-24" version="1">MDFAAFLSNLGNNLGFGLTVTLIGIAIVFLGLTILIGLIKLMENATANLGKGGKKAKKQAEAPAPAPVAAPVVEEAPVADDSELIAVISAAVAMMMEDGSAFTVRRVRRVQNAPAWQKAGREEQVYSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9X9</accession>
    <name>R7I9X9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48266">
        <property type="protein sequence ID" value="CDE48266"/>
        <property type="gene ID" value="BN770_01611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="136" mass="15231" checksum="09E96734F0E8CD85" modified="2013-07-24" version="1">MIQIIAGKKGSGKTKRLIDMTNNAVKTSSGNVVFLDKNDSYMYEVDRAVRFVNVEEYSVSSAEMFLGFLGGMLASNYDVKTVFIDAFLKLIKIDLADAKWFFDSLEKYAQKHDVTFVLSVSADPEALPDFCKGYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9Y6</accession>
    <name>R7I9Y6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000105">
        <property type="protein sequence ID" value="CDE48415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48415">
        <property type="protein sequence ID" value="CDE48415"/>
        <property type="gene ID" value="BN770_01691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="233" mass="26386" checksum="0A0A96D7FA7806BB" modified="2013-07-24" version="1">MGNYRDIFVGTGLLRSFFNSVLYTVAGTIFSMFLATTLAYGLSKKNYPGRALFQNMIVFTMYFGGGVVPFFLLIKDLGLYGNRFAVVIALAFNAFNMIILRNFFESLPPDLEEAAMLDGASPFRIFWQIDLPLMKPALATVTLYFIVDRWNEWFWSNLLFLDSKMWPMQLELRQILWTSSALAADVPAELGRRTYADGMKAAAVIVTMLPIMCVYPFLQKYFAKGVMIGAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA04</accession>
    <name>R7IA04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000093">
        <property type="protein sequence ID" value="CDE48291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48291">
        <property type="protein sequence ID" value="CDE48291"/>
        <property type="gene ID" value="BN770_01622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435679" evidence="2">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="205" mass="22778" checksum="659AD9192AC7C89F" modified="2013-07-24" version="1">MTKKPIIPVLAMLLTLVVLVHAAVLLVQQETAWWLVMDAACGVIGLGMGAMWLICRKRGATKTAWKILLGLIIVQMLTTVALQFVPIERNRHQLLFWGFMSAIQCALVNDMRENSPASVPLSMSHSMMLLNKIIFGLETAVLIFAVGMLICYGERSFYQAMELMGLCVMVMAQSILGMKQNEAAEALKRNEDVENQQKLTQAGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA40</accession>
    <name>R7IA40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein Q</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47387">
        <property type="protein sequence ID" value="CDE47387"/>
        <property type="gene ID" value="BN770_01232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="135"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="219" mass="23417" checksum="B3024D9E70B48D42" modified="2013-07-24" version="1">MNETKQTELRVRPRRTELAASKTDIEWVKTPKKPWQERLLPNLAIASALMLCAVALKTGAIPPLTDAVQSVMSAATDDSLLNGDLGKLSFVSSIFPEASLVFGESGGKLTMPVEAQSVVHAWSQSEPFISWDAQTKIVTSAMAGEVIGVYHGNEDERLVQVLGADGLSCLYGNLASVTVSTGDMVQTGDPLGTLLDGQPCVMEVRQDGLSVDPAVMMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAF8</accession>
    <name>R7IAF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48248">
        <property type="protein sequence ID" value="CDE48248"/>
        <property type="gene ID" value="BN770_01596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="145" mass="16768" checksum="CB8BEF316991B037" modified="2013-07-24" version="1">MRHPAIVFFQTGSNDYVSLKGTAAEKVAACMDYKKQMFAEIHKQLPVAKLVVMSSLLLPCRSEYRELTEEINRALAALCEKTDYLWFVDASAMTWDGQRYADELFIKDGFHLNHEGQLLWMRNYIRPVIETLISEFDLTQVQKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAH2</accession>
    <name>R7IAH2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type transporter integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48258">
        <property type="protein sequence ID" value="CDE48258"/>
        <property type="gene ID" value="BN770_01605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="302" mass="33766" checksum="84773A724BD1DAEC" modified="2013-07-24" version="1">MSRKKAQVGLRARTVDHLNAWLIMLPSLVLMLFFVWEPLFESVVMSLYKTRNIELVNFIGFKNYISVMGKDDFLQALTNTFSYTFWSLLLGFFLPMVLALLIGETVRSKSFFRTVAYLPNMLPGLAVVILWSAFFSGEKSGVLNILLSHLGIAPQTYLTRSEWVIPIIILIATWKGAGATALIYMAGMSSVSPELYEAAAIDGAGIWQRIIHIMIPAIKKLAGTLLILQIISVFQIMYEPMVLTKGGPDNASLSLMQLMWQYAFGGSMNYGKASAVAVIVTLILLVMTAIYSYFDRKESDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAJ7</accession>
    <name>R7IAJ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48610">
        <property type="protein sequence ID" value="CDE48610"/>
        <property type="gene ID" value="BN770_01750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="12"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="252" mass="26608" checksum="41AE8F00C90C5ECD" modified="2013-07-24" version="1">MNSRNSFSSLTITQLVIHLTGALLELYADDTQEIQVMASGDDHDMKAVSLAQNGDTLTLEQSAAALSPLPLSARWLQVTIRIPRAWKGRVEIRTTSGSVHVRGLQVSDLSVESLSGFVMLSDLSSLSLKVKNGSGDIAGSDLSGQDCSLFTTTGMLCLERLAFLNISLSSVSRGAMLSFAEMFSTFKGGSVAGGISLEIPGAQCDAILRSVSGRLLTDGVSIVDGAPSVRVTTASGNLTIRRISPEKLTENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAZ5</accession>
    <name>R7IAZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48473">
        <property type="protein sequence ID" value="CDE48473"/>
        <property type="gene ID" value="BN770_01711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447751" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1003" mass="112424" checksum="8D12E19E4139B95D" modified="2013-07-24" version="1">MLSGKKSLMSMVLALLLLCGAALAEESTSGATALTNADYQQIVSTYSIDASIPGYADYLERYEDAAHPDVTVTVDADTFVRYEDAGIAAQPQVFEDYEGMAGKSVLTDEESLTEWVVDVPESGLYDLTLLYYPYAGKNSAIQRAFFVDGKLPYSELAMVDFNRVWVNGTYEEYTDENGIVVRKWDKDNQGNDLKPSPLEQPEWCTNGLYDTNGYISGEMSIYLEAGQHTLTLLSMREPMLLRSITLSNRSRPAAYADVKAAGDAAGHQDATGVSVRFEAENAVKTSSQMLYPVQDQSSAVVYPMSARYLLNNSIGSSWKNAGQWIEWAFEVPQDGYYEISMVDKQNFVRGIDVYRKIMIDGEVPFAEFNAQPFSYTQTWRIETLSDEDGNAYRVYLTAGKHTLRMEVVLGDMANIIAQVQDCVQQLNNIYRQVIYITGVAPDQYRDYQLTASLPKLEGELRAVQADIDSAIAALEKTAGNDSDKLTVLRTMSDQLDELIEDQERFTEVLSSFKTNVRACGNWITQVLAQPLQVDRFYIHAADTQPKLDNSSWWESLAHETERLYYSFIIDYNKVGNVAEGDTENVVLTLWIGTGRDQANVIKSLIDEKFTPATGISVNVQLVDMNTLLRATLAGEGPDVAIQVANTNGIAGAVLNTGNDTPVNYGLRNAVLDLTQFEDFPEIAKRFNESAIIPFSFDGATYALPDTQTWLMMFYRKDILAEIGLEVPQTWDEVKVAMSILSKNQMEFGMLPSEQVFAMLLFQNGGRYYTDDNAASALDEDVAINVFKKYCEYYTDYKLDKETSAEERFRTGECPIIISDYTTYNNLQVSAPDILGLWDFTTVPGTVQADGSIDRSTGTTGLADIIMSATKHPDESWEFLKWWTSTETQTLYGREMESLMGASARVATANTEALANLSWPMRDYRALVEQMQYVRGIPQVPGGYYTWRNINNAFYTITTDTATNNTTPREALMDKVYYINAEINYKRTEFGLPLHQTEDTTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAZ9</accession>
    <name>R7IAZ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000133">
        <property type="protein sequence ID" value="CDE49084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49084">
        <property type="protein sequence ID" value="CDE49084"/>
        <property type="gene ID" value="BN770_01917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="33" mass="4073" checksum="4801409F536DE87F" modified="2013-07-24" version="1">MNVVVRETGPPYKSDFYNFRKSIKIRRLYEHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB15</accession>
    <name>R7IB15_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48740">
        <property type="protein sequence ID" value="CDE48740"/>
        <property type="gene ID" value="BN770_01799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436340" evidence="2">
        <location>
            <begin position="24"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="305"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="441" mass="47994" checksum="7BE5C30758444004" modified="2013-07-24" version="1">MKRLLSLLLCAVLALLCATTAQAAGVSITLTASEYALHYAFDAGAQDPFVILEYATPAEKGWMMLYSADGHFEGDVSLAYSGAGGKTTVTLTSARTTGSIGKTSTTLPKAADYQKPTGKSNAKVTDFVLTETPEGFHYAFNAIGTDYMLLYWRSKEQTVTQPVYPDENGHYEGDVVSELTFARTQFTVQVKSGSGSMKKEATVRKGYQAPEAPQRQEGRLSGVTVCIDAGHQENGRFVNEPIGPGLTGSTSGKGGMAQGTKTNRRESIVCLEIGMLLRDELLRQGANVVMTREDQTTFHTNIERCEIAEAGGAQIMLRLHCNNSSNRSKRGIQVYGPLNSDYAKAVADADTYREMGQKLLDAMKTRVGMTLANSTGMVRLNDNYVGNNWAKMMCFLVEMGYLSNPAEEYLLVTPVYQQWLAEGMADGVYEIAVARGWVQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBA2</accession>
    <name>R7IBA2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BN770_01736</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S11.005"/>
    <dbReference type="EnsemblBacteria" id="CDE48593">
        <property type="protein sequence ID" value="CDE48593"/>
        <property type="gene ID" value="BN770_01736"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436345" description="Serine-type D-Ala-D-Ala carboxypeptidase" evidence="15">
        <location>
            <begin position="25"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="16">
        <location>
            <begin position="281"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDE48593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="387" mass="41863" checksum="A251CAC6FAD36967" modified="2013-07-24" version="1">MQTGKRLWALTCCMLMIFLPTAQAAHPLESGTPMTLTTPSAILAETATGTVIFEKNADERREVASITKLMTALLVLEALDRDEIALTDSVQISPRAAAMKGSQALLDASAVYPLEDLLRTTIMASANDSAVALSEYIAGSEENFVDRMNRRAAELGMTNTNYVNCTGYPQSGQYTTARDVCRLCCEIAKHPRYNQYASVWIDKLTHPGGRVTDLTNTNRLVRFYEGCDGYKTGSTDAAKYCLAATAEKNGMRLVAIVLGTPVSQTRFNEARQMLDYGFATYRRVVIANKGDLLGQNVEVRGGSAESVPLALGSGLSMLLKNGQQSGLSLSVQLPESVDAPIAQGDVIGLVDVLLDGQVIAKLNCVAAEDVPRPGFIEGLLRILRNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBD0</accession>
    <name>R7IBD0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000064">
        <property type="protein sequence ID" value="CDE47802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47802">
        <property type="protein sequence ID" value="CDE47802"/>
        <property type="gene ID" value="BN770_01364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="717" mass="80309" checksum="0F11D150DABBF184" modified="2013-07-24" version="1">MAATLSVVVPVYGTKRDLPACLESLRTQSLRDAEFLLVDDASPDGAGAVLAEYARRDSRFRVLTHSQNRGLFAARMTGADAATGKYLAFLDSDDFVSVDFYRAAVALAEENDFDLVMGDTVWQRENGDRFVRPVHADCVLEDELRGNAVRDAFFQQAMTCYSFHTIWNKVIRRDLWLRCAPYYAPLAKKHIVMTEDIAFSVVLYFFAQGFGRHRGDGVFYCEHPSSSTGAAGNPAKFRKNYADIAQVFAFADEFLHQQGANQARQQLQKARKWYARMWAEQARKAANQPEISRLTAALCPDFSPDEDANLPEIFWFDQPMTPWRDGTERIKRAILGLDGIDCPVISLDVFDTLILRPFRTPIDLFHTLEGKWQRAARRNMTSFAQARTEAESCARAWLPETQADVTMWNIYSAMMQNLGVSDDCVGQMTYNEREAEIHFCRPRKTGVQLFHLAKAAGKRVVLTSDMYLDADTIRRMLGKCGVRGWDGFFLSNEQNALKWNGALYRKLTAQLGVKPEDVLHIGDNAKIDVEAAKKAGLHALLLPRPADVFMDVDCTQMANLGHGCLAGFTTADAMQPLALRCAQGLAANRFFDDGYAPATADSAFAAYPSRLGYYAVGTHLLALAKWLLCRCRADGVKRLVFLARDGALLRQAVELLRTDADTVETDYIPASRRCLLPALMANPTDWAALPGRWTGYTPRPTGRRCRCAGRSTRPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBF6</accession>
    <name>R7IBF6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48920">
        <property type="protein sequence ID" value="CDE48920"/>
        <property type="gene ID" value="BN770_01859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE48920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="225" mass="25427" checksum="BFD3E115F14C23FD" modified="2013-07-24" version="1">MTEGTQARPERVMVLEPDAERRQMLAQTLMQSGFRCFMADSVHDALPFYQDRQNSACMLTILNARLPWCESVELLSRAQENDWPVLFLTAEAANVAHLQSLFDLPCDALVHPFSPKQLMNAVENLLLLAQSLLRAGPLRLDTLHHRVTMAGEHLTLTAQEFALLEVLVKTPGAAVSRETLLRTAWGYQDLGETRTVDVHIQRLRRKLGKSCIETVYKNGYKLKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBF7</accession>
    <name>R7IBF7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000066">
        <property type="protein sequence ID" value="CDE47832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47832">
        <property type="protein sequence ID" value="CDE47832"/>
        <property type="gene ID" value="BN770_01381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="294" mass="32398" checksum="6279953A008E623F" modified="2013-07-24" version="1">MKLERFAYFLAVAQTGSITLGAQKSFITQTAMSQQMAALEAELGLTLLKRSKSGTSLTEAGQALVPMAEQLVQCYQAIETFADAQRRQPRTLTIAYTGPMEQQLLLRAIPAFRAHHPEVELRVRQLSMARIGTALEAGDCDIALAIPGEIPLQQMKHVTVMERPICAAVASSHPLAGKDSVTLPELTPYPVILLQAGANRRASSQIARWLMGLGWTKDALRFADTIEDQLLMINLNQGISFMPQGSYPVGIRLIPIVSDAPILHHTEAVMRQMTPLHLQFVEQLRQADMAERHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBJ3</accession>
    <name>R7IBJ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000121">
        <property type="protein sequence ID" value="CDE48851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48851">
        <property type="protein sequence ID" value="CDE48851"/>
        <property type="gene ID" value="BN770_01840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="293" mass="31782" checksum="5572E9AD98DE157B" modified="2013-07-24" version="1">MTREGYCTHFASAMTVLCRMVGLPARYVEGFVADVDASGQTVVSGTSAHAWTEIYFRGVGWVTFDATPWTSTQNASSAPNQPDDLPTPSVSPSPSPSPSPSPTPSPSPEMDDSSASHEPTSTPSPAPSPSPEANLPTNTPEPAPAPPDNPPPDVPWLLLILLALMAAAGGRIWWTLPTTRDKQAKDESARCMVWMQATHDALRMAGLRRGRSETPQQFFQRADEAVHAQGALAVVGEIETLAFYARADLLPSDAQALRQAYQTLWQGMKPLRKVRLTLYRAIVPMKMRNFTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBK3</accession>
    <name>R7IBK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000122">
        <property type="protein sequence ID" value="CDE48861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48861">
        <property type="protein sequence ID" value="CDE48861"/>
        <property type="gene ID" value="BN770_01845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="214" mass="24819" checksum="1A2F9A189D5FC338" modified="2013-07-24" version="1">MFREAIIAVTKAADWYALHPLTVEELREKNIGSSVSIRYSTVGKNMTPMGNYEPSPINEGVGNVRKGQFRREIPEKAAEYFAYYLDEEGELLCAEMREKSCRREKELVTVEAHRVLDWTDNISIYSYSANGGPISELMVYVRDDRKCVTARGVWCFSRGEKMWFYGLLLTCFEYHENGKPAASISYRFILTDKQWDKMRDGTIEEPFGYKVRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC97</accession>
    <name>R7IC97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiol-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48127">
        <property type="protein sequence ID" value="CDE48127"/>
        <property type="gene ID" value="BN770_01546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448150" evidence="4">
        <location>
            <begin position="22"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="597" mass="64732" checksum="FE7982CB9BBD69F4" modified="2013-07-24" version="1">MKKMLALVLALAMCLGCAALAEETALVYALGAPMPDFTFTDINGVSHTLSETLKEKEMVLINLWATWCGPCESEFPFLEEAYEQYKDKVEVFALSIDENDDDAKLTEYVASHGLTFPVGHETFNLFAGFGLNGVPTSIVVDRFGNVAFLATGSQTSTDAFVRLFGLFLGDEYTQTNVLAFLPGEKPSIPPTDEAELNRALNVEGTAAPLSFTNSTDEYTWPMAVAEKDDRTVLVSTNTGKDTSSASVLTTVEAKAGDVFAFDYKTSTEAGCDLFCLSVNGQTVKAFGGVKEWATYGYEFPADGTYEIALSYIKDSFQAANEDMIWLDNARVVDGEEAAAVLANNPVYPEGTKMTTISFVGDNVKQVFFTDPKFALMSTFGMTNYYVIDNTESATVKVTLAKGLDPEMYAFGCEAAPENYALTDYMTEDGYVIPNQPIDTNQASGFPYTTYFVVKAGAENVEASAIAIADEPNANAFVAMLQQYGINVPGWKYADGTLPSTDEVAEAPQLPMAGMASYTIKCVDQDGNPVTGTMINVCTDETCTPMPVDENGVLEFTMPAYPYVLHVLIVPEGYEFDKTVEEIAPEAGGEVVFTFQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICR4</accession>
    <name>R7ICR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium uptake protein TrkH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000093">
        <property type="protein sequence ID" value="CDE48292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48292">
        <property type="protein sequence ID" value="CDE48292"/>
        <property type="gene ID" value="BN770_01623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="450" mass="47913" checksum="8B4746FA59A1967E" modified="2013-07-24" version="1">MWKKNRWMRPERVMALGFLALIVLGGVLLSLPCAAQNGRSIGLGNGLFTATSAVCVTGLVAVDTGTTFSLFGQLTLLLLIQIGGLGFMAFATLTMMLLGRKIGLRDRMLLRESMNTSGMSGLVRLTRWYLTAALVIEGGGAVLLAIRFVPLLGWGKGVYFSIFHAVSAFCNAGFDLFGHFSSLTAFQNEPLVLLTISTLIVLGGTGFAVLGEVTRQRFQWRELSLHSRLVLGMTGVLLLMGMTFFCLTEWRNPATLGGISGAGNKLVNALMQSTTMRTAGFNSVDLASMRQSSKLMSIILMFIGASPASTGGGVKTTTVAVLALTVWSVIRGDADVQLARRRVPPGLIRRALAIVSISLAMALGGTMLLTLLEGDGQPFLDMMFEAFSAMATVGVSSAGTPNLTAGSKTVLALMMFFGRVGPLTMASALASRQNRNASKIRYPEEEITIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID29</accession>
    <name>R7ID29_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">BN770_01973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49326">
        <property type="protein sequence ID" value="CDE49326"/>
        <property type="gene ID" value="BN770_01973"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="163" mass="18280" checksum="EB30422C0C98DE14" modified="2013-07-24" version="1">MERICVYPGSFDPVTLGHEDVIRRAAKLFDRLIVAVMHNPQKTGCFPVQERMALLEKLTRDLPNVTIDCWDGLLVDYVRTHQASVVVRGLRAVSDFESELTMAQINSHLLPGMETIFLMTRPEHSCISSSAVREAAAFGADIRDFVPACIAEDVTTHFHRAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDH1</accession>
    <name>R7IDH1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YbbR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000153">
        <property type="protein sequence ID" value="CDE49859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49859">
        <property type="protein sequence ID" value="CDE49859"/>
        <property type="gene ID" value="BN770_02168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="446" mass="48475" checksum="E8E85658EA3DF4E0" modified="2013-07-24" version="1">MTQTPSAKPQKKRDPRLTMLLDGLKRIFIHNWPTKLLALLLAIILWGGLITQDPTLTREKHFSSVSVSVSGEESVKRNGFIVTSDLTSLLGDVSLTADVPQMQYANAKATNYNVRIDLSRISAAGKQEIRILSTNSSTYGTVSSIQPSTVTIDVEEYITRFRIPVSVQTVGSAPEGYYAGAATLDPPTVTISGPKSMVDKIVRAEVVLELNNLPQREGTIRKALAYTLLDENNNAIESDLLEVTSESVLLDSVIVEQTMYAMKTLELSQTGLIQGTPKEGYEIKKISMTPENITVAGWSSEMAEIDALFTDATIDVSGLSDSVKQRVRLSSVPELKYVSATYVNVTIEIGPVLKSKSFTNLPIQIEGLEAGYNASMSRVNASVMITAPQNWLNALQSRDIRLVCDASGLAPGTYSLPVLCRIDADEDEEISVEVVPGNVSVTITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDV9</accession>
    <name>R7IDV9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5'-nucleotidase C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49795">
        <property type="protein sequence ID" value="CDE49795"/>
        <property type="gene ID" value="BN770_02143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005145701" evidence="2">
        <location>
            <begin position="22"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="34"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="4">
        <location>
            <begin position="345"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="551" mass="59037" checksum="C263915C1E04821A" modified="2013-07-24" version="1">MKKFLAVLLMLAMLLCGVAFAEDTAPALTKDVVVLFTSDVHCGIDQGWGYAGVANMRNSLQADNHVVLVDDGDAIQGETIGTLTKGSAIIELMNAVGYDIAIPGNHEFDYGMENFLELTKQAKFPYISANFTCRDELVFAPYVIKEFDGVKIAFVGMTTPNTITSSTPVYFQDDAGNFIYGFMQDETGDKLYAAVQSAVDAARAEGATYVVAMGHMGIEESCSPYMSTEVITHTTGIDAFLDGHAHETMACNEVKNAEGKTVLRAACGTKLSSVGYLRIAKDGKLTTGLYTWTVDIAAPKLLNLTGDAADAVAAQVAKLDEIRQTVVATSQVPLYVNDPVAVTAEGTPVRIVRNAETNLGDLCADAYRALSNADIAFVNGGGIRKQIEAGDITLDDIYSVHPFGNTMCVIRVTGQQVLDALEWGARAVPSENGGFLQVSGLTYEIHTGVASSAEKDENGMFTRVSGEYRVKNVMVGGQPLELDKTYTLASHNYMLLGHGDGYTMFDGCEVLGEDMMVDNQVLITYITTTLGGVVGEQYANPYGDGRIVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDW0</accession>
    <name>R7IDW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Channel protein hemolysin III family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000145">
        <property type="protein sequence ID" value="CDE49518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49518">
        <property type="protein sequence ID" value="CDE49518"/>
        <property type="gene ID" value="BN770_02037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="226" mass="24528" checksum="38B8ABD54E5E26EC" modified="2013-07-24" version="1">MAQGMDEKALKRQKYGIPTYSLAEELLNSISHGIGAGLGIAALVLCIVKSAHAGDGYKLASSIVFGLTTTLLYLMSCLYHALKVNRAKKVFRVFDHCTIFLLIAGTYTPYTLVTLRGPAGWVMFGIVWAVAITGVVLNAVNLKKFAKISVVCYVALGWVILLATKTLVANLAYPGLVLLVAGGVAYTVGAVLYAIGSKKKYFHSIFHFFCLIGTVLHFFSIYFYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDX4</accession>
    <name>R7IDX4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclease (SNase domain protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49641">
        <property type="protein sequence ID" value="CDE49641"/>
        <property type="gene ID" value="BN770_02069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="402" mass="44198" checksum="5CECDBFEBB320D96" modified="2013-07-24" version="1">MAGTTDDGFVDYVAQLKLNMSSATAKTSATVRTHVDGDTVHFDVPESVCEDGVLKARFLALNAPESTGKIEEYGVAASHFTQEKLASAASIILESDSDRWELDSTGGRMLVWVWYQPSEGAEYRNLNLELLQNGYARAYSTANNQYGSICSSALDQARQFKLNLYSGQPDPDFYYGDAIELTLRELRCHPEAYQNKKVAFNGIVTLAHNNSVYVESLDAESGIVFGISVYYGFNLSGKGLSILTPGNEVRIVGSVQYYAAGDQWQISDVSYRMMKPKDPGNIQLLSEGHEPYYTETTLFQLMAQTVLTDENGEEAAYAHADLAQNTSAELHKLHVLSISRDDENSRAYLTVEQDGQQMTVIAPSSFVTDEMVGQSITVRGFVEHSSGSVAVRVYETGLLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEK7</accession>
    <name>R7IEK7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49022">
        <property type="protein sequence ID" value="CDE49022"/>
        <property type="gene ID" value="BN770_01898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447885" evidence="1">
        <location>
            <begin position="23"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="458" mass="50412" checksum="3F148AFC5CB864B3" modified="2013-07-24" version="1">MKKLVALLLCLMMVVPATLASAETAEGKVLNIWCWNDEFQSRFNAYYPEVKEIAEDKSTTTLNDGTIVKWTINPNEGNNYQNKLDEALRAQESAAADDKIDIFLIEADYALKYVDSPYTLDVKADIGLTDEDLAGQYKYTQEIATSADGKLKAVTWQATPGLFAYRRSIAKDVLGTDDPDAVQEALADWDKFNAVAEQAAAKGYYMLSGYDDAYRTFSNNVSAPWVADDGETVVVDANLMKWVDQTKLYTDKGYNHKSSLWDATWAADQGPTGKVFGFFYSTWGINFTLLGNSLETSVANGGKEEVGNGAYGDYAVCQGPQAYYWGGTWICAAAGTDNVATIKDVMQKLTCDAAIAKKITEDTQDYTNNVAAMNELAQNYSSAFLGGQNHIALFAEAAPKIDMSNISAYDQGLNESFQGAFKNYFDGNATIDEAKAQFESIISEKYPELVNFQWPDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEP5</accession>
    <name>R7IEP5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ArAE_1_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49057">
        <property type="protein sequence ID" value="CDE49057"/>
        <property type="gene ID" value="BN770_01903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021062">
        <property type="entry name" value="ArAE_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038323">
        <property type="entry name" value="ArAE_1_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11728">
        <property type="entry name" value="ArAE_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="ArAE_1_C" evidence="2">
        <location>
            <begin position="155"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="331" mass="36932" checksum="F4B2E56ABEA4D064" modified="2013-07-24" version="1">MWKRTHNDRTRGLLLTGLKAAGSAAVAIAVASAIHLQFSATAGIIAILSLMGTKRETMKVALGRLMAYGAALLIAFVCFSLFGDGLLAFGIYLFVFASLCYACSWGYATAMISVLISHFMGTGGMTWTQVGNESLLFLIGTTCGILTNLHLHPDERRLDALLRQADEQMRTALRALAEAADARNPLILLGETLRQADEWAAKNAENSLTDAPTREIHYINMRRQQRRILLQVTQDAQKVQGHPPQEAEVRALIGRIFAEYDRENDCTSLLSALHGLLAEMQRQPLPATRGEFEDRALLYVLLRRMEDFLLLKREFYEAYGFENSQQLEYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IET6</accession>
    <name>R7IET6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell envelope-related transcriptional attenuator domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49833">
        <property type="protein sequence ID" value="CDE49833"/>
        <property type="gene ID" value="BN770_02155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435847" evidence="2">
        <location>
            <begin position="25"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="62"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35288" checksum="D61E0D5AF433B5FA" modified="2013-07-24" version="1">MKRLMSLLLMLCLLIPCLTAPALADTPKPIPTIDYDSIPEPREGLHHYLLLCSDQWTNKLVNTDGIVIVTLDTVTHRIMLTSIIRDALVERPDGVIGRINYIARNSGPEALCKVISQHLGIKIEKYILLNFQMIANIIDYLGGVDITVNASEAAYLRRYPLDPGQTEPTMAQAGTYRFTGRAAVIYMRIRKAGGGGDFMRTQRARTVMSTLADQCRTFTYDQARDLVDVIMKNNLQTNMTLDDMIAAMEQALKLRTCVIEELRIPQDDAVHPISYAGMAVQEVDWVMSREDMSNFLSSGWLVIDDNDEDDPIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF20</accession>
    <name>R7IF20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50399">
        <property type="protein sequence ID" value="CDE50399"/>
        <property type="gene ID" value="BN770_02365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="458" mass="49488" checksum="196B0403490A3C46" modified="2013-07-24" version="1">MTRARGRDADMTQGNILRQYIDFALPLTVGLLFQQLYSAVDSIVVGNFVGETALGAVGSTGNIINMLIGVCNGLSLGAGAVISQAYGAKNHERISKAVHTTMLMTFLLCIVATAVGVAIVKPSLQLMRTPDSMLVEATEYLTIYFEGIAGLLIYNMGSAILRAVGDSRRPLYFLVFSAVVNTVLDLLFVICFHMGVAGVAYATIIAQAASAVLVLYVLTKENASFGLRWSKLHIDGRTLKEILLIGLPASIQQGLTSFSNVFVQAYINDLGDLSASGWAAYNRIDMFLMVPTTAIGQASTTFVAQNWGAQQPERARKGVRTGILLSLGCMGVCAVGVILLARPLLSIISPSEAVISFGARFLYIITPFYLVISFNQMYAGALRGIGESVVPTVIMLFSFVVFRQIYLYLATTMIADEQLRFVIVALAYPVGWMLCSALEAVAYHRSRLFHPALKKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFB0</accession>
    <name>R7IFB0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50151">
        <property type="protein sequence ID" value="CDE50151"/>
        <property type="gene ID" value="BN770_02300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="251" mass="28919" checksum="45A44A63A014E6E4" modified="2013-07-24" version="1">METPIRVVIADDNADMRRIERMMISRAEGFEIVGEAEDGVQLLTLVEQEKPQLVFLDVEMPGKTGVECARVIQDMNPAIVLIFATAHDEYMGDAFEVYAFDYLLKPFKKERVMQTLERAKKRIRHQTDGETPLPVHPTPHPVSGRLMLHHKDGVSFLNVSDIVLVQREDRTTVFYTASGERYVTSDSLSDTEARLDSSIFFRCHKSYIINLNHIKNITPYGRWTYIVHLQGTEQDALITHEKYEELEKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFG0</accession>
    <name>R7IFG0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose-5-phosphate isomerase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50340">
        <property type="protein sequence ID" value="CDE50340"/>
        <property type="gene ID" value="BN770_00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="148" mass="15986" checksum="34E841FA0C5DEE92" modified="2013-07-24" version="1">MIALACDHTGIELKKEMMKLLDSMGLEWKDFGTDTAVSCDYPVYGYRAAKAVVSGECDRGILICGTGIGIGIAASKVKGTRVCTCSDVYSAELSKRHNNSNILTMGARVVGVDLAKMIATHWLTAEFEGGRHQRRIDMITAIENGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFM7</accession>
    <name>R7IFM7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50138">
        <property type="protein sequence ID" value="CDE50138"/>
        <property type="gene ID" value="BN770_02296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436537" evidence="1">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="270" mass="29695" checksum="693BD9E26FA4D9C1" modified="2013-07-24" version="1">MKRLTSILLALLMLVGMALAEETPDAALGDWYALPSDETVLRLTLREDGTFFFGTEGISGIEGKWRKTTDGEYNLAYTNRSSSLLDVIMSMVDSQAPAPDMTMTARLTESGLDVFYGSTAEGAVVHMARDAEELRTERTPRTDTPLEAFAGTWTMETMFLGTMQLTYTPEMGERQVFCTIDGLTMFPGAGLESFPEGTSFPLTFEDGVLRTTIPLTVQMAASSALVKEIVVDYDLTFFQTADGSLYATLRLSDVPDNPTTMFLLVPMEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFN8</accession>
    <name>R7IFN8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulase (Glycosyl hydrolase family 5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50435">
        <property type="protein sequence ID" value="CDE50435"/>
        <property type="gene ID" value="BN770_02390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448241" evidence="1">
        <location>
            <begin position="27"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="571" mass="62696" checksum="32AF62946E04E465" modified="2013-07-24" version="1">MKRLSRLAALLLTLAMLLSLVSIAHAEEKQSATAWLLYFASNHETDSSKFPWWPQHKSADQPSSETGVEATNAEVTGPGMYTVGLKFNWQKAEGAIQFNLVLDNAESLFPGYYVKITDIRVNGKSIDHKPNLYGTFHDDPNAGFAPIYNNYWDKNFSPDSTGPDGLRAFDSADEATYEIINPDDIVAGDTIEVDFIVAANAGEMPEDIGEKPGKLTSLVAPPPVLEDGAEAWLFYQSGSWWPANTKPEGDSAGHASSTTAKITGDGYYTASLSFDRDGWSSPVNGAKKLLLVVSDGTKKLPNSYLKITDIRVNGKSINFTDVGFGAHYGDQYIQATDDYSIIYDDWMVENNSAPWNHKDWNGNVTDNVSAINPDDIKNGMTIDVDFFITSIAGKEPAKDTSSDPIWFPNNTASLAGLTLKDLGIVDDWHAIVPVDLSKTGWQTFPLLAANFKQVGTAYVAVNNGSVTVTCEYNGFYVFEKSQCIKWFTSLDQITKAELTDVSNGLDCGSVVSIADDLGGAQMAYLSINNKITWRNPVDDFGNSLPDYWKNLPQWKEYRANLMEMINAANAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFY7</accession>
    <name>R7IFY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50361">
        <property type="protein sequence ID" value="CDE50361"/>
        <property type="gene ID" value="BN770_00176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="136" mass="16023" checksum="B05E866EC891C8F2" modified="2013-07-24" version="1">MSFFSKMQNALANWMQGRNGPDNLGFTALIAAIVFSLLSLFRLPLASFLSMLCYVYALWRMLSRNVAKRQEENRQFMDKTGHAQTEIRQFFLRLRGIKTYKYFRCPQCKTRLRLKRGCGEKHVTCPKCQHKFDERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGB1</accession>
    <name>R7IGB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50819">
        <property type="protein sequence ID" value="CDE50819"/>
        <property type="gene ID" value="BN770_00217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="350" mass="37415" checksum="452B0FE8B5F411F1" modified="2013-07-24" version="1">MALTRKERTLGCLWAMACGDALGVPSSFLTPEQIKSKYGWIDTFYPPEKGHIFHDGLLAGEYTDDTEQSMALMNAYIRDKKVVPMSVVKEIIAWADRVKDKYASPLGPSTERALKNIAAGGDITVSGKWGNTNGSSMRIAPLGIIHGLRGSTLQELARDVALTDLATHNTRVCNAAATAIAWGVAQAMRGEENLDKIVDATIEAAAEGAKYGFSIPSPDIGMRIALACDIVRKAKDDQQALHDLYAMFGGGDLSADSIPSAIALFLLGKGDVKKTLEYCVNFGGDCDTNGAMAGAMVGAMAGIDAVPQVWRDKISEMNACNFAKDADEILALIPQWHVASESDVADLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGT9</accession>
    <name>R7IGT9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">BN770_02439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50553">
        <property type="protein sequence ID" value="CDE50553"/>
        <property type="gene ID" value="BN770_02439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="91"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="181" mass="19502" checksum="E66B398B4910238F" modified="2013-07-24" version="1">MSRIGRLPITVPAGVTVTVDSNNLVTVKGPKGTLSQQVNHAITVNQEGNMLHLTRANDSKENRAMHGLYRALVHNMVVGVTDGFSKTLELVGTGYRAAAEGGKKLTINIGFSHPVILDAPETISFETPNANTIVVKGIDKQQVGNLAADIRAIRKPEPYLGKGIKYTGEHIRRKQGKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGZ9</accession>
    <name>R7IGZ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49847">
        <property type="protein sequence ID" value="CDE49847"/>
        <property type="gene ID" value="BN770_02162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="1">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="277" mass="30535" checksum="DD8866499E78C959" modified="2013-07-24" version="1">MGRVEQRLYRQQMARRRLGRMIVLTLLIFAAGALTLSRNAASHLTAETIAQPTATPIAAAYDQTVVSREITLAAETWYAIQTGVFSNEDAAREKAELLTDRGAPGAVVEDGEKWRVFIACYGTETDAASVRQRLGENQRIETYLYRWTCPELQLRLKGMAGQVDVAEAGFTLLLQAARTLRDTASLLDAGELTLTEAQEQITALGGQLTLWRQTAQERFRRNPPSPIKELLALSDAWAQIRGNLENQDSKTALSAQLKLEGIGLFGRMLALRQGMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH04</accession>
    <name>R7IH04_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TerD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAPAB/TerDEXZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50613">
        <property type="protein sequence ID" value="CDE50613"/>
        <property type="gene ID" value="BN770_02460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="201" mass="22242" checksum="3101EBB6D0B59382" modified="2013-07-24" version="1">MSVNLQKGQKISLVKPGEPGLKRIMVGLGWDEVEQKRGWFAPKPQDIDCDASVILCGADGRIISNDIKTCCVYFGNLVHSSGAIVHQGDNLTGAGDGDDEQIMVDLPNIPANIDKLVFVVNIYDANVRHQHFGLIRNAFIRLVDLSTQKEICRFNLSDDYSGRTGLVVGEIYRHNGEWKFNAIGQGVTEASRLAELVRLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH16</accession>
    <name>R7IH16_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51099">
        <property type="protein sequence ID" value="CDE51099"/>
        <property type="gene ID" value="BN770_00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436610" evidence="1">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="218" mass="23757" checksum="DD531109BBD17600" modified="2013-07-24" version="1">MKKIIIMLILLLVCFVPALAENTPEVIVDPSVKNVPNYIIDDIITEHPNAGVIHINKVETATPLDAISTCSGLSVYRYSNIAKNYRVFNGRWRTDFIISVARGAETKLSSTYSASISTSASGSVTSGDDKSVPVPSAYTLGLNLSASVSCTISTERTFKGPSEDSEYNSRSFYVAYYGDIGTWTCTATRTFPASTVQMGGTFIEPVRYAEYSIDEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH81</accession>
    <name>R7IH81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000197">
        <property type="protein sequence ID" value="CDE51159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51159">
        <property type="protein sequence ID" value="CDE51159"/>
        <property type="gene ID" value="BN770_00303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="50"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="320" mass="36138" checksum="778F8B30D304EA3E" modified="2013-07-24" version="1">MISILPESNYAAIMTETVEPYLDSRRQEMDMPLSTGGTLHAEVYEQPDATRAVVILHGYTESAEKFREMTWYFLNEKFNVYAIDHRGHGKSVRKISDTSITHVDAFSDYLRDLEEFMSGVVLPRTEHLPRVLYAHSMGGAIGGMTLMNHPEYFARAVLTAPMIAPSSAPLPRWAGKLAADFMCAIGKREDRAFIGKPFSPENEPFETSCATSRVRFDYYERKRIDNAHLQNCSPTYGWVQEAIGVTKVLLDPAKDKQITTPLLLCQASLDKTVCLPEQKQFVAQVPGAKLSVYPAKHEIYMSTNDVMEKYVPEVIRFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHD5</accession>
    <name>R7IHD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000180">
        <property type="protein sequence ID" value="CDE50856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50856">
        <property type="protein sequence ID" value="CDE50856"/>
        <property type="gene ID" value="BN770_00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="208" mass="23717" checksum="96E2C1229A73B164" modified="2013-07-24" version="1">MWTRPDSGDSPVSYPAPTYSACKGIFESILFGPDVEIIPTRVEICAPVQFHSYATNYKGPLRQKKSIDLGNAYQMYSTVLIDVCYRLYAVVVPNHRKDTLSEKTLEWDRRTTSPGHAYQEIFNRRLQRGQCFAIPSLGLREFTASYFGPFRDGTKVCTDMEDIHIPSTLRQVFPDGHKSKVSYRFDNDVTIHAGTLVFPPKRGVHFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHR1</accession>
    <name>R7IHR1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-glucosidase-related glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51304">
        <property type="protein sequence ID" value="CDE51304"/>
        <property type="gene ID" value="BN770_00371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="58" mass="6707" checksum="72D2AAF6B254C4C0" modified="2013-07-24" version="1">MIDKAIASGKSDLNLLFIYNITFRGMGKMMGGMITMERIQVDPRGRFVRHRQQCRDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHS4</accession>
    <name>R7IHS4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein BN770_00015</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000180">
        <property type="protein sequence ID" value="CDE50858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50858">
        <property type="protein sequence ID" value="CDE50858"/>
        <property type="gene ID" value="BN770_00015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="249" mass="27244" checksum="1FBB7236D2B2E181" modified="2013-07-24" version="1">MSGHSKWHNIQAKKGKADAARGAVFTKIGREIAIAVRDGGANPESNGKLRDIIAKAKANNMPNDNIQRSIKKASGELSNVTYEQITYEGYAPGGVAVIVDTITDNRNRTASDVRHCFAKNGGNLGTTGSVSFMFDEKGVLVVERTPGSDEEEMMMMALDAGAEDMKVDDGAYEIYTAPNDFSTVREALEKQGVTFLTAEVDKIPQNTVALPDEETIQKIQKLLEMLEDNDDVQNVYHNAELPEEEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHU4</accession>
    <name>R7IHU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51041">
        <property type="protein sequence ID" value="CDE51041"/>
        <property type="gene ID" value="BN770_00274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="107"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="313" mass="34042" checksum="831A2F3728FAABD7" modified="2013-07-24" version="1">MKITILDGAVENPGDLSWEALAALGDLTVYDYTAPEEILPRIGDAPIILTNKTLITRQTMDECPNLRYIGVLATGFNVIDIAAAKEKGIVVANVPSYGTQAVAQFVMAQLLEICHRIGHHNDAVQQGRWTACRDFSFWDYPLMELAGKTFGIVGYGRIGQATAELARAFGMNVIYYSRHGSGEGYVPLDELYARSDIVSLHCPQTPENVGMIDKTALAKMKDGVILLNTARGGLINEADLRDALLSGKVYAAASDVVSTEPIRADNPLLGLDNMIITPHIAWASHEARQRLMDTAVENVRNFLNGTPSNNVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7II06</accession>
    <name>R7II06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51106">
        <property type="protein sequence ID" value="CDE51106"/>
        <property type="gene ID" value="BN770_00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="333" mass="37352" checksum="04CEDF6AE222C72E" modified="2013-07-24" version="1">MSEKILEVRQLATSFHTERGWQQAIDGVSFDVYQGEILGIVGESGCGKSVTSQSIMRLYDERRLVRYSGTVKLEGQSLLDIPFHKMQDIRGSRVSMIFQDALSSLNPVLTICDQISEPLRIHQHLSKKAAREKALEMLRLVGIPAPEKRLDQYPHELSGGMRQRVMIAIALACRPHLLIADEPTTALDVTIQAQIMELIVRLNEQLNMGVMLITHDLAVVAQTCSRVIVMYLGQIVEEADVLTLFDHPCHPYTEGLMRSIPRMEGDRTKPLYMIPGTVPLLSQIPTGCRFAPRCAYATERCRQETPQLTPVSDKQSVRCFRAAELAQKEATAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7II20</accession>
    <name>R7II20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitinase A1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51235">
        <property type="protein sequence ID" value="CDE51235"/>
        <property type="gene ID" value="BN770_00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436646" evidence="1">
        <location>
            <begin position="37"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="40"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="372" mass="40279" checksum="0DF4E926A98C48B9" modified="2013-07-24" version="1">MPRTKETKGRRLSRVMLTVLSAAIIAASVFIPAARAENPPMTVVYALDSANLTFRDSDAANINQINYAFALIRDGEAVGSHWAAIDRVRAYLRKHPHIRGVMAVGGWGAEGFSDACATADGRARLADSILRLMDENGFRGVDIDWEYPGTSAGSIKSRAEDVENWYALLTLLRDGLDKRTAETGQKHTLSVAVGAGDSLLKPIDPARLNALADQVVVMAYDLCGFDRETGHHAALYPDDNTRQSGARAVRTLTQGGLSADKILLGIPAYGRMWRQVSGRAVTQTAGISGTKVLNFPDLLALESQGYTRYYDGAAKAAYWVGSENFVSGEDEQSIRDKAQWAVQQGLQGAAVWSYGQDDSGKLLAWLKDALAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7II35</accession>
    <name>R7II35_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">BN770_00454</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CBJB010000222">
        <property type="protein sequence ID" value="CDE51459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51459">
        <property type="protein sequence ID" value="CDE51459"/>
        <property type="gene ID" value="BN770_00454"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDE51459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="253" mass="27472" checksum="2F29AE6E46C1A439" modified="2013-07-24" version="1">MRVIRSLCIAFSTYSRIPVPQVAWTDENRKYSMCFFPLIGAVIGLLLWGWLALCDALGFGALLRGAVGALLPILVTGGIHMDGFMDTSDALASWQSPEKRLEILKDSHVGAFAVLGCAGYLLLDAALLSELPTTLAPMMIGCFMLSRACSAWAMSAFRNARPKGMLDAFAQAAQRRMLTISCTVYTVLCAVLWAIVGGWLAIPCLLAAILCAWYYRRMSYKQFGGITGDLAGWFLQITELTLTAVIVIGGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7II83</accession>
    <name>R7II83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51033">
        <property type="protein sequence ID" value="CDE51033"/>
        <property type="gene ID" value="BN770_00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="154" mass="16910" checksum="9C1F55FB0465F5E9" modified="2013-07-24" version="1">MTCDVHLTRVLGLPAVLRGRSQGHVERAVLENDGHALRGLIVRRGFGGAKWVARDSIALLGDVSVILRACPTHLPRKTDFRLRTVKDTRGLTLGCVTDVLISADNLLVSELEVSLGLIDDFRDGRRRIRHFSASPDGDVLVPEGEILLEGRETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIA3</accession>
    <name>R7IIA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000200">
        <property type="protein sequence ID" value="CDE51196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51196">
        <property type="protein sequence ID" value="CDE51196"/>
        <property type="gene ID" value="BN770_00323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="155" mass="16942" checksum="5FD2821FDBFCC00C" modified="2013-07-24" version="1">MLPKVSKGFRAIFVAVMCVVCVALCVLAVRLAQQGEQLRLTQLQLDASLARLKLQQTQRAQIDVDLPETLAQLQAVQPEADAASAREQELRAQRKALRSENAELAAQAETLTQQLALLRTPDSELIGEVETLQKTLSSLQAQVDAARQLLGQAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIC8</accession>
    <name>R7IIC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51370">
        <property type="protein sequence ID" value="CDE51370"/>
        <property type="gene ID" value="BN770_00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="45" mass="4626" checksum="BCF4C40942F7D59A" modified="2013-07-24" version="1">MATWIVGGVLLVIVGAVIWKMIKDKKSGNSACSCGGDCGKCKGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIT2</accession>
    <name>R7IIT2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="4" type="ORF">BN770_02425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50507">
        <property type="protein sequence ID" value="CDE50507"/>
        <property type="gene ID" value="BN770_02425"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="76" mass="8502" checksum="55374C458ADAF5AA" modified="2013-07-24" version="1">MSTFETLKGMIVKQMKVNPDTVTESSRLVEDLKADSANVMVMIMDVEDTFGITVEDDQIMKLKTVGDVVKYIDANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIZ8</accession>
    <name>R7IIZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BN770_00453</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000222">
        <property type="protein sequence ID" value="CDE51456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51456">
        <property type="protein sequence ID" value="CDE51456"/>
        <property type="gene ID" value="BN770_00453"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDE51456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="171" mass="18532" checksum="92934FD1A0EDB9A9" modified="2013-07-24" version="1">MIVLVTGGSGCGKSTWAEKLVSALPAEKRVYIATMQVYDEESVQRVARHRAQRADKGFTTIECEKDLASADVPEGSVVLLEDLVNLMANEMFGGGDTSRILPALNVLACKCQHLILVTNDVFSDGIHYPDSTREYLRQLAKINAEAAKMADCVVEVVYSIPVCVKGALPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ29</accession>
    <name>R7IJ29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAPAB/TerDEXZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50612">
        <property type="protein sequence ID" value="CDE50612"/>
        <property type="gene ID" value="BN770_02459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="194" mass="21027" checksum="5BBF56F16124A87B" modified="2013-07-24" version="1">MAVNLSKGQKISLDKGMTLALVGLGWDTNRYSGGAEFDLDASAFLLGANGKVRKDEDFIFYGNLKSADGSVTHTGDNRTGEGEGDDEVLYIDFTKVPADVERIAITVTIYEAQERGQNFGQVSNAYVRLARRSSENDSVGTEELRYDLGEDFSVETALVVCELYRSGATWKFNAVGAGYQGGLYALCKAYGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ30</accession>
    <name>R7IJ30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC-type sugar transport system permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51645">
        <property type="protein sequence ID" value="CDE51645"/>
        <property type="gene ID" value="BN770_00547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="35562" checksum="D455EF006CB5E3F6" modified="2013-07-24" version="1">MTAFWKKYFALRQRNACIAWDRAKHMKFCYAFLAPYALLFLTFYILPMLISIYYSFTYNNILEPARFIGMDNYITLILKDDVFLTAVKNTFLLAVITGPVGYIMSFCFAWLINELPRWVRTIAVVIFYAPSIAGNAYYIFSIIFRGDAYGYLNAILMKLGILNAPILWLTTPDYIMPVIIIVTLWMSMSTGFLSFVAGLQGVDRSQYEAGYVDGIRNRWQELYYITLPNMKPMLMFGAVMSITSAFGVCDVPMALAGFPSTDYAAHTVVTHLFDYGFTRFEMGYASAIATLLFLVMILCNKLIQSALRRIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ56</accession>
    <name>R7IJ56_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51784">
        <property type="protein sequence ID" value="CDE51784"/>
        <property type="gene ID" value="BN770_00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436673" evidence="1">
        <location>
            <begin position="23"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="72"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="522" mass="57940" checksum="7A0514437DE122F6" modified="2013-07-24" version="1">MKKLLTALLTLAMAFTMVFATAASAEDGYKDSITWVIGNDQDILDPQNNVSNSKVMPQYYNGLLGYDNDGNVVCKMAESYEASEDKMTWTFHLRQDVYFHSGRHCTAHDFEATFDRLLNTENPQRYTSNASSFIDTAVATDDYTFVITLKEPKAFFLQAIAKQWAFVLNPEYIEKYGADLGKTAESVDGTGPFKCTQWDKGEVMKFEAFENYYEGAPLTHEIVMKIVPEQTSRAIAVETAQADIADGVSPDDAVRLDALDGVTVSKTDGNGCHLFQFNCASDHAPMSIPAVRQAICYAIDRNAICEYLYSGLGEIPIDSIMAPSVAGYSSVGVVPYDPEKAKQLLAEAGYPDGFDLTIMTSAMYNRAVEMAEIIAEELKEIGINAKLEVVERAVFTSAWASFTPDEFNEKFGWDMFIMGSGGDSDADTLLKRIMHSADTNVNNYGFYNNAEVDELLEKGAVTMDETERNAIYARIAQITMYEDPFGAYMNLRKNVYALSDKIEGFAVNSSNTMDLAHVRCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJC1</accession>
    <name>R7IJC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51864">
        <property type="protein sequence ID" value="CDE51864"/>
        <property type="gene ID" value="BN770_00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="322" mass="36217" checksum="4E5A3788421358CA" modified="2013-07-24" version="1">MFSFFIGDLLSLPLPLLHYEVSSVNGFYLTPYFTLGWLNIPVFHRNAGMFNEPGSHQIFLNFALLFLMSDETRMGMSKKKYRWAIALLIVTILSTLSTTGFICLGVVLLTVAFRKKGGKMARSIKMAAFVGLILLFVIESVTGVVERKIVGRNSGGSFYTRWNDTFSGFEIGLESPIAGQGVFSERKAEILLEHRVQNISNGFAAFVMDTGLILPAVWLWLTYRGIRTKFAKARLLYVLGVFLLYFLCINTEGVFLNILFLGLLGKWQPDAEDTPDQQANARSQKKRRWRCTVPPEKLRLTFNPQPEDAAQEQTGETGGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJC9</accession>
    <name>R7IJC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51586">
        <property type="protein sequence ID" value="CDE51586"/>
        <property type="gene ID" value="BN770_00501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="203"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="7">
        <location>
            <begin position="445"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="615" mass="68669" checksum="F1CA620F2D5E3678" modified="2013-07-24" version="1">MQAQETLRKYFGHEAFRPGQEVMVNALTHHRDALGVMPTGAGKSMCYQVPALMMPGVAIVISPLISLMADQVAALKSAGVPAAYLNSSLTPRQMELAMQRARQGAYKIIYVAPERLETPSFQAMAQSMPISLLAVDEAHCVSQWGQDFRPVYLRIADFVDSLPTRPVMGAFTATATERVRQDIIRLLRLQNPETVTTGFDRPNLYFEVIRPKNRDAALMDILRRKRGESGIVYCATRKAVEQVCDKLIRAGIDATRYHAGLSDEERKENQEKFQYDTCPVMVATNAFGMGIDKSNVRFVIHYQMPRSMEAYYQEAGRAGRDGEAAECILLYNGSDIFTAKWMIEHTEPNENMTAAEQSAVRYQDMNRLNRMVDYCTKPGCLRAFILRYFGENTAQDCGHCSACCGARYGEAEEATQKRQRIAADGAHLGQQATAEKVGSIGKIEAPAGGDLFEQLRQVRMALAKLHHVPPYIICNDATLTEMARRKPETLDGMRSVSGMGEIKTARYGEAFLGVIRPYVAQERKMKANVKLLAERAQSAAFRNPVRTTPKPMPPKPLYTPPPAPVIPDIDWDNLSDPEVLSDAYLSGLTIREMSQKSGLSESWLREKLRSMDLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJF7</accession>
    <name>R7IJF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPK2 family polyphosphate:nucleotide phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000233">
        <property type="protein sequence ID" value="CDE51616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51616">
        <property type="protein sequence ID" value="CDE51616"/>
        <property type="gene ID" value="BN770_00521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="290" mass="33753" checksum="1B77930C6CAFCADF" modified="2013-07-24" version="1">MGIVLLKDYRWDGSKKLELKDAETGAPEFVDKKTLKAQTMENLAEAAALQDKLYAQGREGILIAIQARDAAGKDSLIKKVFGQLNPAALEVAAFKAPSKEELSHDYLWRIIRTVPPRGKIGVMNRSHYEDVLVTRVHHMEKGYAMPSRVTEDPDFYPKRYQQIRNWEQYLYENGYRVVKVYLNVSRDEQKRRFLDRLEREDKHWKLSVDDMRERRLWKQYDEAFEDAINATATKESPWYVLPADDKWFTRYLMSEILLDVLMDVNPDYPPLDPAEAAKVPAILAELENGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJF9</accession>
    <name>R7IJF9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">BN770_00450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000222">
        <property type="protein sequence ID" value="CDE51453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51453">
        <property type="protein sequence ID" value="CDE51453"/>
        <property type="gene ID" value="BN770_00450"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="241" mass="26028" checksum="41B00AC05D33744D" modified="2013-07-24" version="1">MLCGLLGRIPVLIAMALLDWMGIAITSMAKEARGVEKALGQGVAAGRTQVARIVGRDTQDLSEEEIIKATVETVSENTTDGVISPLLYAAIGGPILLWGFKAASTLDSMVGYLDEKYRDIGWSSAKLDDVLNYIPARLTALLMVIASYLIGLDGKNAFRIVRRDHANHKSPNCAWSESAAAGALHIQLGGTHNYFGKPVEKPTIGDADRPAERADIRRANRLLYASSLLMMVLIVLIAIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJN3</accession>
    <name>R7IJN3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">BN770_00477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000226">
        <property type="protein sequence ID" value="CDE51528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51528">
        <property type="protein sequence ID" value="CDE51528"/>
        <property type="gene ID" value="BN770_00477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="149" mass="16322" checksum="FF326E1C282C2383" modified="2013-07-24" version="1">MRCVIQRVAQASVSVAGEQIGTIQQGFMVLIGVSTDDTDHDVHYMAEKVPNLRIFEDEAGKMNRSLKDVGGAILAVSQFTLYGDARGGRRPSFIAAARPEEANEHYEQLVAAWRAQGIHVETGRFRADMQVSLVNDGPVTILMDSTKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK08</accession>
    <name>R7IK08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the P(II) protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51960">
        <property type="protein sequence ID" value="CDE51960"/>
        <property type="gene ID" value="BN770_00719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="8">
        <location>
            <begin position="17"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="581" mass="62014" checksum="1B444952C22F1D60" modified="2013-07-24" version="1">MDLSSIMTSVDSEIFGVWFLIGAALVFWMQAGFAMVETGFTRAKNTGNILMKNLMDFCIGTVMFILIGFSLLLGEDLMGFIGKPGFDIFTAYPNFDFSNFVFNLVFCATTATIVSGAMAERTKFLSYCVYSAVISALIYPIEAHWIWGGGWLSQLGFHDYAGSCAIHMVGGLCALIGAKMVGPRIGKFSKDKSGKIVGVNAFPGHNIPLGCLGVFILWLGWYGFNGAAAKSIESLGSIFLTTTVAPSVATVVCMIFTWVHYGKPDVSMCLNASLAGLVGITAGCDVLDCTGAIIVGVVSGLIVNFGVWFLDNKLHVDDPVGAVAVHFLNGIWGTLAVGLLATGTTPDYPEGMLTGLFYGGGFELLGLQLLGVLSVCAWTAVTITLAFLLIKAIFGLRVSREEEIAGLDIMEHGLASGYADFMPATSLLTSVEAVPTVAVETPKVSVDDAVPVVVRSDKAPASDVKMTKVSILCKQSSFEVLKTAMEEIGVTGMTVSQVLGCGMQKGRPEYYRGVAVEMNLLPKVQVDIVVCKIPVRTVIDTAKKVLYSGHIGDGKIFVYDVENVIKVRTGEEGYDALQDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK16</accession>
    <name>R7IK16_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51786">
        <property type="protein sequence ID" value="CDE51786"/>
        <property type="gene ID" value="BN770_00613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="280" mass="29924" checksum="151039344A1A34FD" modified="2013-07-24" version="1">MKNKHPVLRRFMRRKVSVVAAAVLILFVLIAILGPLVWQVDPLKQSVMKKYGPMTVQHPLGTDNLGRDTLARMIYGARVSLAISFAGVLSGALIGVLLGVSAGYFGGWVDAIISRFIDILLAFPGLLLAITIVAVLGPGSVNTVIAITIFTIPGLTRMVRSVVLSLKSSEYVEACKTMGESNLRIIFTHVIPNSMSQIIVNVTLSLGTAILTASSLSFLGLGVTPPEAEWGAMLSQMREVIRTYPTGVLVPGIAITLVVMSFSLVGDGLRDALDPKLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK17</accession>
    <name>R7IK17_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51970">
        <property type="protein sequence ID" value="CDE51970"/>
        <property type="gene ID" value="BN770_00724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031599">
        <property type="entry name" value="ABC_tran_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16949">
        <property type="entry name" value="ABC_tran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="576" mass="62947" checksum="1CA4522EA33FB8A2" modified="2013-07-24" version="1">MKSYLLLLRLNLRNLLAGFRGAMRKPNGKIDISRLILYPLALLGMLTLAGFVIFMEFSMFSAFEMLNAPEMLPGLAILLAMVTALLFSVFQMLAALYFSRDTASMAYLPLTSRTVLAAKWTEVYVSELLFSLLIAAPAVVLYGIHYAADWTYYLRMVPVLLAVNCIPLTISLLLASILGRFTSLTRHKEVWVVLGTVLMLVVVLGLEWSILPKIPEDADAAFFAQMLTGVQPMLRAFIHAFPPVAWAVDGIAGDWLQWLAFLAVSIGGAALVIALVGGSYLDTTLRQNEGSRKARRVRVTDKTFRAHSPFMAIYRREWNEILKVPVYLLNGVLGAMMLPIMLIGMSVGMSSEQDSEVSWNFLLRLMQDSVSPMDVMLILTALLMFISWVNPIIATAISREGGRMPIAKYIPVSPRTQLWAKLSVSLTINGAAILLMGIAVAALLGTHYLGAVLGAVVLANLFSLATGCIALTIDASRPILHWQTEQQVMKQNMNQMICMLVVLLVALIPVAGVVGMMVLSSAAQDMEAPSMLMRFAAEHAVGLRSAVAALLMAAEAGVSILILHKVGEKRFSAIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKA4</accession>
    <name>R7IKA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-L-arabinofuranosidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51901">
        <property type="protein sequence ID" value="CDE51901"/>
        <property type="gene ID" value="BN770_00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="296"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="488" mass="54303" checksum="E2D6AD6F20227695" modified="2013-07-24" version="1">MAAILSINAAGQSGKKINKNIYGHFSEHLGRCIYGGVYVGENSDIPNVNGMRTDVVQALKKIGVPVLRWPGGCFADEYHWEDGIGPKETRKRMVNTNWGGVVEDNSFGTHEFMELCRQIGCEPYVNANVGSGTVREMAEWVEYMNSTGDSTVVQKRWANGHKEPFNLKYLGVGNENWGCGGNMRPEYYADEYRRYQTFCRNYGDNKLYRIACGPSSGDWNWTDKLMERAGRYLDAITLHHYTVPYAWDKKGSATDFDADEYYLTLRNAAYMDTLIRGHLAIMDKYDHEHRVGLIVDEWGTWFDCEPGTNPGFLYQQNTMRDAMVAALTLDILGSHCDRVVMANIAQMVNVLQAVILTDGAKMICTPTYHVFDLYKAHHDANYLPSAITCGECGGVKQLTATASEKDGVITLTATNTSCTDALDVVVHLSGASAKNVTARILTGDMRDKNTFEDAEKVTVKPFDAVRVTETGLKMTLPACSVVEVTIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKM0</accession>
    <name>R7IKM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GTPase (G3E family)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000198">
        <property type="protein sequence ID" value="CDE51162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51162">
        <property type="protein sequence ID" value="CDE51162"/>
        <property type="gene ID" value="BN770_00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="1">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="311" mass="35580" checksum="FA1C17CDADC85675" modified="2013-07-24" version="1">MSEQEFTPVYLITGFLESGKTQLINSMLTDDNFSRGQKTLVICCEEGVEEYETAKNTTVVVLDEADEMNTKKMEALDKEYQPERVIIEYNSIWTIERLGSCMLPRKWEVVQIITTVDANTFDNYFTNMRQMLTDPMKVADLILVNRCQPGANKSPWRRQLKAVNPKTNIIFENTDGTSEDGVADEDLPYDMKSAVIEIKDEDIPTFYLDSLDHADRYDRKTVRLVGQAFADRSLPKGYYMFGRMAMTCCANDIQPIGWITQGIQKPSTKTYFRLTAQCKAVDAQGEKMLMLQEARAEIVPPPEEEYLNFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILT2</accession>
    <name>R7ILT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51592">
        <property type="protein sequence ID" value="CDE51592"/>
        <property type="gene ID" value="BN770_00507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="7">
        <location>
            <begin position="26"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="8">
        <location>
            <begin position="341"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="585" mass="66722" checksum="176AF0DFFE1B6691" modified="2013-07-24" version="1">MEEATTRSNFVWEAVEQDLKDGRYTQVHTRFPPEPNGYMHIGHCKALITDFLTAEKFGGKCNLRFDDTNPAKEDTEFVEAIKNDIHWLGFDWTGGLYYASDYYDKCYEIAEDWIRRGLAYVDELNKEQMREYRGTLTKPGKNSPWRDRPAEESLDLFRRMRAGEFAEGQYTLRAKIDMASPNIVMRDPTMYRILYKEHWRTGKKWCIYPMYDFAHPIGDALEGISHSLCSLEYEIHRPLYDWVVEHSQSMLPARPRQIEFARLNMTRTVMSKRKLRALVMGGYVKGWDDPRMPTLSGLRRRGCTAAAIRDFVSRIGLSKADSTVDTALLDACIRDDLGEKAARVMAVLHPLKVVLTNWDADKTLTLTVENHPKHPEMGSHTVTFGKELYIEQEDFMEVPAKKFQRMYPGFEVRLNGAYIVKCEGCKKDENGNVTEVYCTVDMDSLSGSEGADRKIKGKTLHWVSAADAVPFEARLYDPLLADDSALEDETEPTAEDAVDAEETEEAEEADANLSRADYDFLKKLNQHSLTVVRGVIEPYAKECAPGTALQFLRTGYFCKDPDSTAELPVFNRTVGLRDAFAKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMW8</accession>
    <name>R7IMW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed DNA polymerase III subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51977">
        <property type="protein sequence ID" value="CDE51977"/>
        <property type="gene ID" value="BN770_00729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="321" mass="35505" checksum="30CBC87B3C3CA680" modified="2013-07-24" version="1">MAAQTGNAAPVLSDFQGQGAVYDGLMRTLHDGTFVHAYLITGLEGMGKRTLARLLAQYWLCQAPEGEKRPCGVCRACQQVRDGTHADLVIIAPGKPISPDVRPDMKSIPVDEIRALIAITARHTFEGGRRVVLIEQADKMNPPAQNALLKTLEEPVPGTIFLLMTESPSLLLPTIVSRCRELKLHPWDDRTVLSVLEKHGVTGQRAQEALHVSGGSIGKALAVAGDEQYWQRRSEVMRDFFALERRSDILRISSTWKDRKDDAEELLDDVEDMLRTLLLCHLGQRSESAVTPYPAAWQRFSRAGGLSAMMRGSAARENYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I321</accession>
    <name>R7I321_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pre-crRNA processing endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46264">
        <property type="protein sequence ID" value="CDE46264"/>
        <property type="gene ID" value="BN770_00813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010155">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029950">
        <property type="entry name" value="Cas_CT1134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01876">
        <property type="entry name" value="cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="214" mass="24931" checksum="CED17BE29541DD98" modified="2013-07-24" version="1">MSIKMEVWGEYACFTRPEMKVERVSYDVPTPSAARGMVESVYYHPGLKWHVDKIYVCKPIRFTNILRNEVASKISVRNVLTEANGKKRSYIDRNADIQQRATTMLRNVHYVIEAHFEMTDKANPSDNPGKFQDIVKRRLRSGQAYMQPYLGCRECTAHFRLWEGGDIPTIDETRDLGYMLYDMEYSDPENIQPMFFRAQMVHGVIDLTDCEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3H3</accession>
    <name>R7I3H3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46185">
        <property type="protein sequence ID" value="CDE46185"/>
        <property type="gene ID" value="BN770_00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="290" mass="32326" checksum="13D9359511B56829" modified="2013-07-24" version="1">MELTQLTYFLTVAQMQHMTRAAEALHIAQPALTKSVQRLESELGVPLIARKGRGIALTPYGQRLADELQQPLNQLSHIPEMMRQMANQQARTLHVCVLAASDLVTDAAVRFRQTHPDVHFAMTLLPRISDAAHPPYDLLVDSDGMNGDDGFHERILLAVPQSSPLAARTSLRLNDLRGQEFISVMGNRRFREQCSQLCQQSGFMPQYAYECTEPSTVRNLISLGCGVGFWPEYTWGAPGEGIRLLPIDDARCVRRIVLHCGASGDIRPLAEEFRAALQDELQLLASKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3Q0</accession>
    <name>R7I3Q0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00928</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46534">
        <property type="protein sequence ID" value="CDE46534"/>
        <property type="gene ID" value="BN770_00928"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="353" mass="38410" checksum="B6C675948640CB70" modified="2013-07-24" version="1">MAITTRAFGTTQDGQNVTMYTLTNHSGASVSMLDLGAIVTNILVPDKSGKLADVALGFDTLAHYEGGHGAMGDTIGRFANRIGGGCFTLDGTEYHLYQNDGENTLHGGKAGFQKKVWQATPVAGDTVDSVKFHYVSADMEENFPGNLTADVTISWDDDCNLTFHYQATTDKATVINMTNHTYFNLAGYDHGTVRDHAIYIDSDVVTAVDSGLIPTGGYMPVSQTPLDLREEMLIGDGLDCMNECVPMRYAKGYDCNYVLRKGSAMGLCACVHHEESGRTMEVITDQPGVQFYTACTTDYADGKGGMHYLPYSGLCLETQHYPDAPNHPNFPTTTLRPGEIYDTTTIYAFRVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I400</accession>
    <name>R7I400_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46355">
        <property type="protein sequence ID" value="CDE46355"/>
        <property type="gene ID" value="BN770_00837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="58"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="221" mass="25002" checksum="EB0BBBB4A6051890" modified="2013-07-24" version="1">MSEQNQPEKKKNFQHHMAVPGKKGIIYTIARGIFWIYFHLFCFMHCTGREKLNLDAPYIVIANHTSFADPIIAAMLIRRYEVNFLGKIELAKAPVVGKLLMHLHMIPVDRHHSDMEAMRACLRVTKAGGVLGIFPEGTRHKEGIMEHVESGVALIALRSGVPMIPLYIGGKPRLFRRLDVRVGDPIVMDDLRARGVNRDTCEELLARITETYRALTAHPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4B7</accession>
    <name>R7I4B7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide chain release factor 3</fullName>
            <shortName evidence="6">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prfC</name>
        <name evidence="8" type="ORF">BN770_00899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46490">
        <property type="protein sequence ID" value="CDE46490"/>
        <property type="gene ID" value="BN770_00899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="539" mass="60962" checksum="2F31E0E78BCB5B55" modified="2013-07-24" version="1">MLPAHDTPAFRELLHQQVEKRRTFAIISHPDAGKTTLTEKLLLYGGAIRSAGSVKARKSDKHATSDWMDIEKQRGISVTSSAMQFEFDGFRINILDTPGHQDFSEDTYRVLVAADAAVMLIDAAKGVEAQTIKLFKVCRMRNIPIFTFVNKMDRAAKDPFALMEELEQVLGIRSCPINWPIGTDGDFQGVYHRDTKMVELYAGGDHGKSMVQKTDIAIDDPALEHVLAKHYRERLAEEIDLLDEAGDAFDLDKVRRGELTPMFFGSAVTNFGVEPFLERFLQYTPPPLPRKSDIGDIQPEEPYFSGFIFKIQANMNPAHRDRLAFMRIVSGAFEKGMEVWHSGTNKTVALKQPQQFMADEREAVEEAWAGDIIGLFDPGIYQLGDTLSGGPKLHYENIPVFAPEFFSRVRPADSMKRKQFQKGITQLAEEGAIQTFIRTETGREEFMVGVVGVLQFEVLEHRLKTEYQVDIVMESMPFRFVRWVVSTPKPIDQLKLTSTSGRAKDSRDRDVLLFENEWSIRLACENNAGLELAETANRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4D2</accession>
    <name>R7I4D2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">murB</name>
        <name evidence="18" type="ORF">BN770_00914</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46505">
        <property type="protein sequence ID" value="CDE46505"/>
        <property type="gene ID" value="BN770_00914"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="36"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDE46505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="33812" checksum="D747FCB29714817C" modified="2013-07-24" version="1">MRESTLRELTLRLKNAAPTLQLEENADMARYTTLHLGGPADLMANPDDPAQIPLLIETARALDVPVTVIGNGSNLLVRSGGIRGLVIRICRNLRGVEVNGDRIRAQAGTMMSSLSMAAADCDLGGLTFASGIPGTIGGGVYMNAGAYGGEMSQVVTLVEGYNMAGEPFRYSRPDLHFGYRFSRLMKENKIITHVTVQLPPGQREDLLAEMVDFNRRRAEKQPLTFFSAGSTFKRPEGAFAAQLIDECGLKGARIGGAQVSEKHAGFLINRGGTAEDFLALMAHVQRVVYRQKGIKLEPEIKILGEDAPVEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4M8</accession>
    <name>R7I4M8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ORF">BN770_00783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46208">
        <property type="protein sequence ID" value="CDE46208"/>
        <property type="gene ID" value="BN770_00783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="285"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="459"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="611" mass="66210" checksum="87C1F33CCBB3C480" modified="2013-07-24" version="1">MCGIVGYIGAEQAQDILLDGLSRLEYRGYDSAGIAVMDGGVIRLSKAKGRLANLAARVASNPLPGTIGIGHTRWATHGEPNDINAHPHTDMKGHIAVVHNGIIENYEELRTQLKAKGCVFVSETDTEVIAHLLHTLYDGDMLSTILRAQTMLEGSYALCVLNAEAPDTLYCTRKDSPLVVGLSDGAQYVGSDIPALIRHTRTVELLDEREVAVLTRSGVRVYDHFGNERALKPIHVDWDVEAAEKGGYAHFMLKEIHEEPAALKKTFSAHVDAEKMAIRPGAFPISAEEANSLRTLTIVACGTAYHAGVVGKYVIEKLARLPVVVDVASEFRYRNPILGAGDCFLAISQSGETADTLAAMREAERLGAKVMALTNVVGSSIARTAGDCVMYTYAGPEIAVASTKAYITQVEMMVLLAIDLGVKRGHLTESVASELLRQMADIPALAEQVMALEPAVQRFSSLYHDRQHVFYIGRGLDNALAMEASLKLKEVSYIMSEAYAAGELKHGTIALIEQGTLVCALLTQEHLADKTLSNVREVKSRGAKVLIVCPEALRDRAVKDADELWVIPDAASDLLPLLAIIPVQLFAYYMAVSRGCDVDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Q2</accession>
    <name>R7I4Q2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000021">
        <property type="protein sequence ID" value="CDE46620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46620">
        <property type="protein sequence ID" value="CDE46620"/>
        <property type="gene ID" value="BN770_00960"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="10">
        <location>
            <begin position="189"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="216"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="483" mass="52697" checksum="FFC78B1BC11D6426" modified="2013-07-24" version="1">MQDLVVVVNLNGSACRMMAQKLRAEHFYCRIVSSACAAEDIQRMGARGIVLAAGVSGEAADVPFLMDYLQTGLPMLCVGDSALSLCQTLGGALSEPVPQDGAMQIHLDASDALLDGMEDTDRYQPTARFMSLDGAQATPIATTDGGMLGFHASRRDVWGFSFQLERNDPFSSHLLVSFCQNICGCTAWWTNQALIDRAREEIDRAANGGSALCSLSGGIDSGVCAVLGNLAIGHKLHCIFIDTGLLRKNESEQVMAYYHDNLGLNLRRIDAREEFLTALAGVSDPAEKERIVTERLMSILSREAAAIDDIRLVIQGTNVTDTLYRPHTGSTIDGLPIIEPVRELFKDEIRQVGQELGMPAVLVNRQPFPGSGLASRIMADVTAERLDILREADDIFRHDVEDSNQNKRLWQYFAALALSPFPDGGYVVTLRAVQTAEGAAGNTARFTADLLERVTAHILAQCPKVQRVFYDLTPSKSYKRANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4R7</accession>
    <name>R7I4R7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="5">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BN770_01063</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46864">
        <property type="protein sequence ID" value="CDE46864"/>
        <property type="gene ID" value="BN770_01063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02077">
        <property type="entry name" value="P-type_ATPase_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="15">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDE46864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="901" mass="98399" checksum="8D36EF64A34D1C94" modified="2013-07-24" version="1">MTLNLKKKVTLTASQMLAENNRATADRLTWAAQTDEANLRTALNVPENGLTEEMAEEARDRYGRNVLPTSQRTPLYKRLAAAFINPFTVVLVLLAIFSALTNVAMVDPGDESWATVIIITIMVLISGILRFVQETRSGNVAAKLSEMIHTTVCVTREGEKKEIPLEEIVVGDIVSLSAGDMLPADVRILRAKDLFLSQSSLTGESEPVEKSGAVCQTVGSLTECGNLAFMGSTVVSGSATAVVLAVGHDTMLGAMAKALNVKPPKTTFEKGVNSVSWVLIRFMLLMVPIVLLINGLSDGDWIQAGLFAISIAVGLTPEMLPMIVTTSLAKGAMTMSREKVIIKDLNAIQNLGAMDILCTDKTGTLTQDKVVLEYHLNVDGEPDDRVLRHAFLNSYFQTGLKNLIDIAVIDKQRQIGADELIARFEKVDEIPFDFERRRMSVVVRDRKGKTQLVTKGAVEEMLACCTHAESKGKIVPLTDKVRAYVLRKADELNGGGMRVIAVAQKTNPAPEGQFSTADEKDMVLIGFLAFLDPPKETTRDAIHALREYGVGVKILTGDNEKVTCAICRQVGMNAERVLLGADIDAMDDETLAQAAEEITVFAKLSPAQKARVVTVLRQKGHSVGYMGDGINDAAAMKAADVGISVDTAVDIAKESASVVLLEKDLMVLEKGVIEGRKIYANMMKYIKMTAASNFGNMFSVLAASAFLPFLPMASLHLILLNLIYDISCTAIPWDNVDTEYLKVPRTWDASGISRFMLWMGPVSSLFDIATYLLLYFVIAPMACGGMTFAQLTNPAMQDKFAALFQTGWFIESMWTQTLVMHMIRTKKLPFIQSHASLPVMLLTMLGIAVVTLLPFTPLAAPLGLCALPPVYFAYLALIVLGYMVLATLMKKLYIRKYHELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4W4</accession>
    <name>R7I4W4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46263">
        <property type="protein sequence ID" value="CDE46263"/>
        <property type="gene ID" value="BN770_00812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF539">
        <property type="entry name" value="PTHR24031:SF539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="748" mass="83432" checksum="FF01AC9A0823BEA0" modified="2013-07-24" version="1">MEYVTHLREDGSYQPLKEHLEGTATRSAKFAASFGASSHAERTALLHDIGKYSPNGQRRQRDPEHTAKVDHSTAGAKAAADLDDMHAAFAIAGHHGGLPDLGTRLSLDDGTLCARLNKKLTGGDDPSAWRSEISLPTGVQPTPPWLPRNDVRLTAMYIRMLFSCLVDADFLDTERALSKEEKPRGIGDSMPALLEKLQAHVAKWLEEPKSDLCALRNEVLRRCLRGSEDPQGLYSLTVPTGGGKTVSSLAFALSHAVKHGMKRIIYVIPYTSIIDQNAKVFRDILGDENVVEHHSQVDLPDTDAETPDALRKRLACENWDAPVIVTTAVQFFESFYAAKPGRCRKLHNVANSVVIFDEAQTLPISLMRPCVSVIDQLVQHYGVTAVLCTATQPELLSIFSGFTAGTRIQELVPDPDALFSSLRRVTFQQDGMVSDEELAARIRQENAVLCIVNSRKQARSLYEALPEEGRFHLSTLMNAIDRERTIATIRERLDKKQCCRVISTSLIEAGVDVDFPTVYRELAGLDSILQAAGRCNREGKEAAQDSIVHIYQTEHAVPPIMRPNIESCRTVLRLYAEDIGSRKAIHAYFCDLLFKRGENQQRSRPVSSENDLLDTSKTLSSEARFAFRETAEHFRFIDTDTVTVYIPTPENSEDIKALRDGHYSRELFRRLGRCGVSIYRREYQALCSIGGGTEIADAHCGILRRHGNCRCALRHSKRHQIVHAGMRLAGQLHERTGAIRLTYIMKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4W6</accession>
    <name>R7I4W6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46536">
        <property type="protein sequence ID" value="CDE46536"/>
        <property type="gene ID" value="BN770_00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="132" mass="14134" checksum="2EE575C7068B11FF" modified="2013-07-24" version="1">MSKIAVIYWSGTGNTQQMAEAIANQAHADLFTASEFTADKAANYDAFAFGCSAMGAEQLEEDEFEPMWNAVAPVLGSKKVVLFGSYGWGGGEWMDIWKRDNAGLNIVDTVICQDAPDDDALAACRAAADKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4X0</accession>
    <name>R7I4X0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPIC-type PPIASE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46924">
        <property type="protein sequence ID" value="CDE46924"/>
        <property type="gene ID" value="BN770_01073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="490" mass="53100" checksum="44D6947D40ECFB7B" modified="2013-07-24" version="1">MKCIEMGENKFMQKKALLALLLVLTMILSGCSLIVKDEAVDAARVVIRVGDDTYTKAQVQAQIQNQVNYMTALYSRYGLSFDSTNADVMSSLTDNVLNSLVERSVLLAKAKELGLDQLTDEEKTKIEENTASQLDSLRKSAATEFSLDLETQLEEINAKLDELGYTEEVVRKSVTESLLITKAEDYAVKDVTVTEDEIVADFNSKVEAAKTSYESDLSAYGKAVLNGTTVYYRPAGYRNVKQILIKYSDEDSALVSNIQTALDNVITEQNNAANVMAKLGVANMDELANQVTVTLKPATETPTATVEVESSVSAFEEGLDETVAATAVTIAEAKAKRAFLEQQLADAKAKALANITPEADEVLAALAEGQDWDTLAEAHNDDPGMKAGAVNAATGYPVCEGFTQFDAAFVEGAMALQKVGDYSDKIEGSYGYYIIQYTSDVVEGAVDMETVHDTISSSLLSSKQSTVRDEVVAQWVKDANATINKDILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I508</accession>
    <name>R7I508_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46576">
        <property type="protein sequence ID" value="CDE46576"/>
        <property type="gene ID" value="BN770_00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="389" mass="41773" checksum="135EE9AACC31B447" modified="2013-07-24" version="1">MEKHPVALIPIATYDQAAVDTAVLQGVDLLGGIARFVQPEERVLLKPNLLSRALPQKAITTHPAVFSAVCRLLHESGYTHLSYGDSPGNPTTSPDKAAQASGIAEVAVRYGVEMADFFSGSVVPFPDGHTAKSFYLCKGVQDADAMINICKMKTHALERITGAVKNLYGCITGVNKAAGHAAYPDSWVFADMLTDLHRCVRPRLHIMDGIIAMEGNGPTSGTPIAMNVLLFSADPVALDTVYAALIHLDPATVPTCVRGAKGGIGVMDEGLIDVLTPDGVLTVSQAREKYGNAQFDVFRGTMKKGLLPKLMPLLPFLQHRPKVDLKKCIGCGVCQEACPVPEKAVHSGHGKKAKYDYKKCIRCYCCQEMCPAKAISVYRSPLNKLLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I533</accession>
    <name>R7I533_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46353">
        <property type="protein sequence ID" value="CDE46353"/>
        <property type="gene ID" value="BN770_00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="6">
        <location>
            <begin position="136"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="210" mass="23010" checksum="232A5DE004D250E0" modified="2013-07-24" version="1">MPRCIILTPLYAGEELPWIAPQPGDFLICADGGWACARQFGLTPQLVVGDFDSMPPAMRPDVPTLTLPTEKDDTDLVVCLHEGRKRGYTEFILAGAIGGRFDHTLSCLQCAADCALRGERAWLVDGQNRATILAPGTHHLPKMPGRKLSLLAYSPEVRDVTLTGAKWTLTRATLTYHYPLGCSNEFTADMAEVTFREGLLMVCFSADKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I540</accession>
    <name>R7I540_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46363">
        <property type="protein sequence ID" value="CDE46363"/>
        <property type="gene ID" value="BN770_00844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="59"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="261" mass="29131" checksum="1369D42CF279D99A" modified="2013-07-24" version="1">MTHSTAPAHPKKAAYTSAALCLLLSVLTFCYAGPLHQDATTVLAAKRILPVYSVERDDRVISISFDASWGGDQTMRILDLLDEYNAKATFFLVGIWVDKYPELVKEIHDRGHEIGNHSSKHPHMTKISESRMRQELSDMAEKLEAITGEKPTLFRPPYGDYNNTVVSVARSEGYEVVQWSIDSLDWKNKGAADLIRRATTNVAPGDIVLFHNDSKYILDALPTILKTYHQQGFTLIPVGELLLEGNTTIDVQGRQHPAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5B5</accession>
    <name>R7I5B5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46448">
        <property type="protein sequence ID" value="CDE46448"/>
        <property type="gene ID" value="BN770_00866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="255" mass="29422" checksum="6A977E78A3B78CF6" modified="2013-07-24" version="1">MKMELGAQTFTVRDYMQTTWDFREAMKRIAEIGYTCVQLSAVGNVPVQAQRDICDEFGLKIVLTHTNPDRMISDPEGVIRDHDILGCDYIGIGMMNPKYQRAEWIDQFAKDFTTPAKKMRDAGKLLMYHNHNLEWTRLRDGRRIMDVLLEQMPADLMGVTLDTYWVQAAGADVLEWIDILQDRIPCVHLKDMSVNGFDQRKAVVGEGNLNFPKILEKLQTLGKTKYMLVEQDDCYGESAFDCLKRSYDNVRKMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5N3</accession>
    <name>R7I5N3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="9" type="ORF">BN770_00937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46568">
        <property type="protein sequence ID" value="CDE46568"/>
        <property type="gene ID" value="BN770_00937"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041856">
        <property type="entry name" value="NAD+_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="478"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="647" mass="71862" checksum="DD9D64C8462FC9F5" modified="2013-07-24" version="1">MRGLVRVGAAVPSLALGNVKENMKRHLAMMREAKEKHVSIVTFPELSLTGYTCGDLFFQRRLLDDVTDALLALKDEMPEGILAVVGAPLEIEGALYNCAVVLHKGEIISAVPKTFLPNNGEFYEKRWFQSGDARRDASVAIPKLKTDVCRQAIFETEDGVRFGIELCEDLWAPLPPSTMLSVEGAEIILNLSASNELLSKREYRQQLISQQSARCQCGYVYVSAGMGESSSDLVFSGHSVIASCGTVIRESEGYLADNYLMTADIDIDRIRADRMKQSSFADCAAQVRAMWKQEPNILRTMENALLPDDAAPDYRVSKHPFIPSDKASRQLRCAQILAMQATALARRLAVTGGKVVVGISGGLDSTLALLAACKAVDMLHLPRTNILGITMPCFGTTDRTYHNALDLMTSLGVSQREIPIHNAVRQHFADIGHDESDHSVTYENCQARERTQVLMDVANKIGAIVLGTGDLSEIALGWCTYNADHMSMYGVNSGVPKTLVRWVIQTAAENEAFSSSRECLQSILDTPISPELLPPDEKGNILQQTEDVVGPYALHDFFLYYAIRFGYPPKKVFDLCCIAFQDDFSCETILKWLKNFYRRFWTQQFKRNCMPDGVKIGSIALSPRGDWRMPSDAQYKAWMDECDCIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5P3</accession>
    <name>R7I5P3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound O-acyl transferase MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01091</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46965">
        <property type="protein sequence ID" value="CDE46965"/>
        <property type="gene ID" value="BN770_01091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="502" mass="57394" checksum="ADEDDC57E12DEE62" modified="2013-07-24" version="1">MLFNSIEFLLFFPAVVLLYYAIPGKLRVFWILLTSYLFYMNWNPAYALLLLFSTAVTFLFGLLIGKRRTKEKAAAEAGRPIRQISKVWVGVSFAVNLAILFFYKYFDFTVDNLNVIRGWMGLAPVTPGFDVLLPVGISFYIFQALSYVVDVYRGDVRMETNFIKYAAFVSFFPQLVAGPIERSTNLLTQFDTPHKLEYDNVRDGLLRMVWGFFLKIVIADRAAILVNQVFNYCNYYEGPTVLIAAVLFAFQVYGDFAGYSNIAIGAAQVMGFKLMKNFERPYLAVSVSNFWRRWHISLSTWFRDYLYIPLGGNRKGTVRKYINQMIVMLVSGLWHGAAWNYVIWGGINGLYQVAGGITKPFRRRIQQKTGARTNTLSWRIGQVLTTFVLIDLSWIFFRANSLGDAMHLLSSLFRGWSTSIFFDGSLLKLGLDQTEWLVLLGALLILLAVSLMQEKGVSVLEAVKRQQLWFRWLIYLAAIFVVLLTGIYGPGFAASSFIYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5V1</accession>
    <name>R7I5V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00964</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000021">
        <property type="protein sequence ID" value="CDE46628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46628">
        <property type="protein sequence ID" value="CDE46628"/>
        <property type="gene ID" value="BN770_00964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="40"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="235"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="393" mass="44376" checksum="42AFEE2DBCA8599D" modified="2013-07-24" version="1">MSETNQLPTSFEEMDLSKEVLRAIKDMGFTTPSTVQAKTIPLMMSGADVNAIAPTGTGKTCAFGIPMLEYVQLNEPEVQEVVLAPTRELALQIGDELTKLAKYIKGCRIAVLYGGQPIPKQLAALKRKPQILVATPGRLLDHMNRGNVHLNAVHTMVLDEADEMLNMGFVKDVTHIIEATPDERQMVLFSATTNQDVLTIAWKYQHDPIEVTVEATKQDRPQIAQYVISTEQNKKIDHLLYLLDADVYQRVMIFCNTKFMTDRLTERLKKEGYQAECIHGDVKQSQRNVVMNDFRRGKFPILIATDVAARGIDVDDVEAVINFDLPAENEYYLHRIGRTGRAHKHGVSFSLVTFQESVRMDEILKYMIAKPLPLHFEDGILRNEDGTPFFDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5V2</accession>
    <name>R7I5V2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46866">
        <property type="protein sequence ID" value="CDE46866"/>
        <property type="gene ID" value="BN770_01065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="53" mass="5451" checksum="B1C5D1EAFCABB759" modified="2013-07-24" version="1">MMFIGIMLIIVGILALVASTIGFGDIGLSFAAIGVVAILCGIGFLKINKRLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I677</accession>
    <name>R7I677_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000030">
        <property type="protein sequence ID" value="CDE46996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46996">
        <property type="protein sequence ID" value="CDE46996"/>
        <property type="gene ID" value="BN770_01097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="554" mass="60103" checksum="8836D9DE4AB0B073" modified="2013-07-24" version="1">MPLKPVFDKAPLTMLTSQPLRAGQVRVNLPALTRLYAQVENRREPLLLEGAFRLACLVTADAMQSPAVTAIREAAAAQREDGSFALTIEDSVYVLRAVWALYETEAKKEDLTVLLRWFQWAAKQWDDIAADEYVRAFPADLLELLEKVYRITGIPAMLKLARTLSASTMNWSSVLTATPIQTPVSKAVSAEELDAGLKKENGDLEGYYTRLALTTNAAALADGARAALARGWLNGSATEMNAAKTGWEKISRYHGAISGGLTANPMLAGGNPSTGIFNDTLGAWAEAFVCAGMGAHAVWAWDELERLVFNALPACVEETRVQLVQRVNSLAAQETQQGSFALTLGRLARGYALAIQSAVTAWVDGFAVNMLIPGKYAVCDSKMVLTIDAQGERYAIKMHMKNDQKAFFHMRLPAWASSSEILVNGAPTAEYRLVDGCIGIEHVWHDGDEIVAMLEQPVMRHNSAYHQATYLTRGPQVLALSADGDWAYALCGNGKVTESGVTAPFAPIAWKKGNNAPVDVPVLPELTGDIRALPLTPYADTPVRVALFPRGDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6F3</accession>
    <name>R7I6F3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="11" type="ORF">BN770_01030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46808">
        <property type="protein sequence ID" value="CDE46808"/>
        <property type="gene ID" value="BN770_01030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="100"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="101"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="441" mass="48499" checksum="319375574A625CAB" modified="2013-07-24" version="1">MAFEGLTEKLQGALRKLSSKGKLTEDNVKEGMREVRMALLEADVNYAVAKDFIKKVTARCVGTEITGTLSASQQVIKIVNEEMTQLMGGENARLTWSSGPLTVYMLCGLQGAGKTTMAAKLANYLAKQGKKPMLAACDIYRPAAINQLQVVGKQVNVPVYEHGTQDPVKTALEAVERARYLGRDVLIIDTAGRLHIDQELMDELVRIKENVHPQEILLVVDAMTGQDAVNVAQTFNEKLDIDGVILTKLDGDTRGGAALSVRAVTGKPIKFSGTGEKLSEIEPFHPDRMASRILGMGDVLTLIDKASEAFDQEDAEKLAKKARTADLTLDDFLDQMQSMKKMGGIKSMLEMLPGMSGKDIDVDENAMKKPEAIIRSMTPKERRNPGVLNASRRKRIAAGSGTTVQDVNQLIRQFDQAKQMMKQVTQMKGKGRMRMRFPGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6G1</accession>
    <name>R7I6G1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46818">
        <property type="protein sequence ID" value="CDE46818"/>
        <property type="gene ID" value="BN770_01035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="117" mass="12727" checksum="2F39AC282621D608" modified="2013-07-24" version="1">MFLRKLLVIVVPLVLCGLCVFFLPLLGGFGLWSDLLQGLILGALLALLLPLSGASRRKEPFATLLVVPMIVLIVLLALQLMRALGVALPFQPVNGCTMMIECTFLSFMTVQAIRTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6H2</accession>
    <name>R7I6H2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47464">
        <property type="protein sequence ID" value="CDE47464"/>
        <property type="gene ID" value="BN770_01265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025964">
        <property type="entry name" value="GGGtGRT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14057">
        <property type="entry name" value="GGGtGRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="340" mass="36234" checksum="D8A84619E6F26A9D" modified="2013-07-24" version="1">MALFENYEGRMPQLQPVLEKYGFKDFDELKAYNNSKGVDAYKIVEGIQPICFENAKWAYELGAAIALKKGVKTAAEAATCIGEGLQAFCIPGSVADQRQVGLGHGNLGAMLLDEKTECFAFLAGHESFAAAEGAIGIARNANKVRKNPLRVILNGLGKDAAMIISRINGFTYVQTKYDYLSADVKEDHALTVVKEVAYSNGERSKVKCYGADDVREGVAIMWHEGVGVSITGNSTNPTRFQHPVAGTYKKEMIEAGKKYFSVASGGGTGRTLHPDNMAAGPASYGMTDTMGRMHSDAQFAGSSSVPAHVEMMGLIGMGNNPMVGATVAVAVAVEEAQKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6J6</accession>
    <name>R7I6J6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000040">
        <property type="protein sequence ID" value="CDE47235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47235">
        <property type="protein sequence ID" value="CDE47235"/>
        <property type="gene ID" value="BN770_01175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435468" evidence="2">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="277" mass="29656" checksum="A16AABC4408D3177" modified="2013-07-24" version="1">MKKGFRTLLLLSACLVLLAGCASEPKTQYNVNTQGAANTSSTNTAGSSLPADYDPASEEDDYTGDAASTPEEIQLPTLVTPPPTNTPIPVISGQYSGATPVVIDPIDKPTPTPLPALSFTYQTYTASNLNLTFEGPAGWVVDTSEANSYKLQSPDWATGYAATLVIRANSTSIEYTTDSLTTEVKSMLTNLRNANYPKFSPSNTATRKGLFLGATGVYANYTATLDGNLQIAGRIAAVYKNNVLYTVHLTYPAGYTDTYKTNVYDKLRDTLKVITAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6S4</accession>
    <name>R7I6S4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47330">
        <property type="protein sequence ID" value="CDE47330"/>
        <property type="gene ID" value="BN770_01211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="240" mass="27013" checksum="493E794DADA05801" modified="2013-07-24" version="1">MIALLLNSGLGSRMGDETREHPKCMCRLTEQETIISWQVKLLRRIGVTEAVVTTGHLADTLIAYLESLDSGIRFHFVHNPKYRETNYIYSMYLARNLLRGQDVISLHGDLVLHPTVMDALAAAGRSVMAVDSTQPLPDKDFKALIQDGRIRRVGVDCFDAGSVECQAAYHWQAADFSSWMDEIERFVERGDVKCYAENAFNAVSGEIPLYPLECGGRLCAEIDNQADREVVLTRFRQEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6W4</accession>
    <name>R7I6W4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 2 CUT1 family (TC 3.A.1.1.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46242">
        <property type="protein sequence ID" value="CDE46242"/>
        <property type="gene ID" value="BN770_00798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="294" mass="32785" checksum="1C4204C943AD6D19" modified="2013-07-24" version="1">MQATAKEVKLPPVKKGKKNFSVFPFVNGLFFLLFCLFILVPLWKVLVDSLDLTTGYGMKLWPENFGLAGYQSVFSNPTLLRPLMISVVTTVAGTFLGLFLSTVGAYVLIQWDMPGRNFFAGIMLFTMIFQGGMIPTYLVMKNLHLTNTLWVVILMPAINVYNLVLMRNFFEGIPTSLFESATLDGCSPIQIFYKIVLPLSKAALASIGLMFAVSYWNDYTNYKLYITTDQSLYNFQMKLRSIIMGSDLPAANGGAAENTVTNAAVIVAILPFMILYPFLQKYFVKGINIGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I726</accession>
    <name>R7I726_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47450">
        <property type="protein sequence ID" value="CDE47450"/>
        <property type="gene ID" value="BN770_01252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="241" mass="26841" checksum="174936A65270E0C5" modified="2013-07-24" version="1">MMTVHEVSRRTGVSVRTLQYYDKMGLLPPTARTEAGYRLYDDAALERLQQILLFRALAFSLKEIQAILQSPNFDRNRALDQQIHLLTLKRAHIDNLITFARGLKEMGGTNMDFSAFDTAQMDEYAAQAKAQWQHTPAYQEYAKKSKGRSKEAAAALANGMMLIFADFGKCKSADPASPEAQALVKRLQAYISENYYHCTPEMLNALGAMYRAGGSFTKNIDNAGGEGTAEFAARAIDAYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I758</accession>
    <name>R7I758_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">BN770_00834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46352">
        <property type="protein sequence ID" value="CDE46352"/>
        <property type="gene ID" value="BN770_00834"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE46352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="26819" checksum="ECC7B8BAD1EC7AE5" modified="2013-07-24" version="1">MELGKLLTEGKGKRVYATDDPDQAIVYFKDEAMAFHGLKRGRILGKGEVNNAISEQFFKMLEENGIPTHYLRRLDARQSLVKRCQILPVSVKVRNRVAGSLAKRIGLPTGTKLDTTVIELELKGSEMDYPLINITHVEALHLATREEMNYVIETARKINQILSDFTSEIGVELVDFKLEFGRYHGQLLVADEISPDSARFWDARTHEPMDLDRFRRDLGGVEQAYQDLLHRMMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7C5</accession>
    <name>R7I7C5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aluminum resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47386">
        <property type="protein sequence ID" value="CDE47386"/>
        <property type="gene ID" value="BN770_01231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009651">
        <property type="entry name" value="Met_g_lyase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46658">
        <property type="entry name" value="PTHR46658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06838">
        <property type="entry name" value="Met_gamma_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="416" mass="45123" checksum="C82823B85F6B271E" modified="2013-07-24" version="1">MTIEELIAQAENGLTAQFARIDRMEEIGTRRVLDAFREHQVAYRHFAPTTGYGYDDVGRDTLEKIFAELFGTQAAIVRPQIASGTHAISLCLFGLVLPGDDIVSATGMPYDTLQDIIGWGEGDAPVGSLREMGVSFHPVALRDGKIDLDAVENAITPKTKLVIAQRSRGYDWRPSLMPEEFAPLAKMLHEKHPGVRLMVDNCYGEFVCEKEPSHYGADVCVGSLIKNPGGGLAPTGGYIVGTQDAVERIAYRLTAPGIGLEVGSYAASYQPFYQGLFMAPHTVAQAIKTACLAARVFEILGMTTTPAADEPRADIIQAIQMRTPERLVAFCQGIQMASPIDSMALPEPWDMPGYNDQVVMAAGTFVAGASIELSADAPMREPYTAYMQGGLTYTHGRIALQMALNRMVEQGALTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7P1</accession>
    <name>R7I7P1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4180 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47874">
        <property type="protein sequence ID" value="CDE47874"/>
        <property type="gene ID" value="BN770_01409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025438">
        <property type="entry name" value="DUF4180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13788">
        <property type="entry name" value="DUF4180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4180" evidence="1">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="122" mass="13599" checksum="10FE4C79093F19EF" modified="2013-07-24" version="1">MYIQQVNQDGVSIALIRSEKPLMTDVQSALDLMMTVRAETGCKRIALNREAIMGDFFVLSTGIAGEILQKFVNYGFKLAVYGDFAHETSAALRNFIRESNEGRDIFFQPDANSATEKLARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7X0</accession>
    <name>R7I7X0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="6">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mraY</name>
        <name evidence="7" type="ORF">BN770_01459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47959">
        <property type="protein sequence ID" value="CDE47959"/>
        <property type="gene ID" value="BN770_01459"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="359" mass="38897" checksum="62032326EA19F2DF" modified="2013-07-24" version="1">MLTNVLLALVLSAAIALATGPKLIEWLRGHQMKTSENELGPKEHLKKRGTPIMGGLMIALGCIVSFVLCAAYTGAWVTTILPLLLVSLGSMAVGLADDWTKAVKHRSEGLTPWQKIIGLSVVCLGFSVWCYFTQGSKVLLPFANTEWDLGLWYIPLLALTVLFMTNSANLQDGIDGILSSVTSVGCMGWAVIAGLSAVTVYQHLNGGSFGIPMVKIPDDPDAARALQDNYSAIAIFAAALCGGCLGFLRYNRYPAKVFMGDTGSMFIGGAVVGMAMLLRQPFLLLLIGFTCCMSSVSVILQRYYYKATRKIYGTPRRLFKMSPLHHHFEKCGMKETQIVLMYTVVTLVLTALAVISVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I825</accession>
    <name>R7I825_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46667">
        <property type="protein sequence ID" value="CDE46667"/>
        <property type="gene ID" value="BN770_00980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="282" mass="32603" checksum="9BE846BF4E6E92FA" modified="2013-07-24" version="1">MTVKYYYHSGFSVASGETLLVFDYWMGRQGKKLPAAQRITPETLSHFSEVFVFISHGHEDHFDPVVYTWEQYAPVTYILPETMDASLHGRRMGVGGEITLSRHVKVKAFDSTDEGLSYLVEMDGIRIFHAGDLNNWHWREESTPREIEEAERDFQQVMETMRGEKVDVAFFPVDPRLGMMFDAGPNYFAMVVKPRLMIPMHFWERAEVIREYARRSRSPQTEIIAMTTPGDMILLEFDEQENMTVHMQSVTSAPVARNKKVQLEAYDGENPFNDSDLPVDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I855</accession>
    <name>R7I855_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48059">
        <property type="protein sequence ID" value="CDE48059"/>
        <property type="gene ID" value="BN770_01518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="148" mass="16728" checksum="4889304F74DB6D79" modified="2013-07-24" version="1">MYLTSYFTSPNQPQLLAQLRACEWGAAKFLTELLEKEQFHHTLGAGDCYFLMAGDQIAAFATLTDCDCVDAPELHPWCGFVYTFPAYRHQRIAGKLLHELAKIARQNGQSCVYIATDHANVYEKYGCTYLDSRSDIDGEISRIYTLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8D0</accession>
    <name>R7I8D0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48139">
        <property type="protein sequence ID" value="CDE48139"/>
        <property type="gene ID" value="BN770_01553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="341" mass="39361" checksum="CB5F25BFFBAA2154" modified="2013-07-24" version="1">MKANDGQANLILLDSAPQPEWNFAALMEAETGEKWNIWHIDSYFSDSAWKKKAKFFLFPLKVLRHRKEFGTILSYQQFYGLFFAFYSAIFHLKKHCHLIVTTFIYRPKQGWKGKLYAWFMRKAVNSPALDKIVCFSSSEPAYYQSIFGTDKFTYVPLGLGDLNRGGHIPQGEERFILAAGKSNRDYDFLVDALKDTPYQVRILSDAYNHPNPGSNIRIYHDVFGEKYYQMLSECCCVIVPLADARISAGQLVFLQAMMFAKPIITTESDTVRDYIESGKNGLIIPKQRDALRDAVRRLYEDEALYRGMAKEGRCRFLESYSVASMARRIGSIWRKLDEKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8H5</accession>
    <name>R7I8H5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47593">
        <property type="protein sequence ID" value="CDE47593"/>
        <property type="gene ID" value="BN770_01304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="119"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="216" mass="24221" checksum="4FF8FAFECEF1C4ED" modified="2013-07-24" version="1">MRKHFDDQIAQLGEQMMAMGALVENTIERAIRALQTDDMAEAAAIRDGDHVVDEKEREVEAMCIHMLLQQQPVARDLRTISAALKMITDMERIGDQASDICEIATMGHLRSPRPEHFASMAQAAISMVHRAIDAYVHKDIELAQQVELSDDIVDALFNDVKADLIAGLRGHPDRTEECLDLLMIAKYLERIGDHAVNIAEWVVYAITGLYKGEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8X2</accession>
    <name>R7I8X2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily transporter MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48060">
        <property type="protein sequence ID" value="CDE48060"/>
        <property type="gene ID" value="BN770_01519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="433" mass="47054" checksum="0BE2D1DED524D3F5" modified="2013-07-24" version="1">MKLHSFFESLRELRTFLLLFTTQALSSLGSAMTSYALVIWAYQQSWSALSTALLTVSSYAPYVVFSLFCGALVDRLDTRRTMLVSDALAACTTVAALVLLQTGRLQITHLYLLNALNGLMNTLQQPASEAATTALLPKSQYQRVGGLRYLSSSLSGLLTPVLAMALMMLGGLRAVMFADLATFVVAFTALLCFIRIPKRQTGNQHESFLDSTRQGLRFFRQAPGLLTLVLYLAAINLVSSMYEAALPSLLLSRSWGGETVMGIFSTVTALATLMGSLLAVLLPAPKSRVRVVCGCLLVSMGTENFLLAFGQNLPTWCVGAALGWLLIPVMSANLDALMRLNIPEEMQGRVYAVRNALQFFTIPVGYTLGGALVDAVFRPLMRNPLPWLEMLFGRDEGSGAACFYGVLALMGVLTCLFFQSRKSLKTLEGDKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8X7</accession>
    <name>R7I8X7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48065">
        <property type="protein sequence ID" value="CDE48065"/>
        <property type="gene ID" value="BN770_01523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447684" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="33" mass="3823" checksum="13B7533B01DFFCAD" modified="2013-07-24" version="1">MKFAAAMMNMMMPMCMCNMSMFRRAANSMRHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Y6</accession>
    <name>R7I8Y6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48075">
        <property type="protein sequence ID" value="CDE48075"/>
        <property type="gene ID" value="BN770_01529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436277" evidence="1">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="148" mass="15777" checksum="D68D112CF345061F" modified="2013-07-24" version="1">MKSFVQKHGKLLISVAVALMVAAACMGTLMQNKQTRSLVGAWMIYDGYDGGDLAPNVLVFAADGTGIGYALDSDGLDNGMENILLPRERLSDAQPFHWQQSGKTLTMTYDAGDTRQLEIGISPMGNTRELSLTLGGLGGGWIPVTIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I908</accession>
    <name>R7I908_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GtrA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47007">
        <property type="protein sequence ID" value="CDE47007"/>
        <property type="gene ID" value="BN770_01103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="177" mass="19950" checksum="78815D94D06204A4" modified="2013-07-24" version="1">MADTSQPHSSRCPAWLREGGLYLIVSGVVTVLKYVLLLFLPRAFAFLPMRDFGWPGIEMTLLGETFRWNIFGYDTAHGGLPYLCAYMTAMVLGECVNFPLQRKYVFRAKGHLAQQVLLYALAFIVITCLVNSINCVWVAVAAKFVPDWVYTLGTLFFNGTISAVVFFFVNKRIFPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I917</accession>
    <name>R7I917_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="6" type="ORF">BN770_00114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48105">
        <property type="protein sequence ID" value="CDE48105"/>
        <property type="gene ID" value="BN770_00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="200" mass="22080" checksum="3D57703D7654F86D" modified="2013-07-24" version="1">MKWKKGRKRPMNEQQKTPKQPEEDMTPDVTDQEQPAAEAPQEPAPQADAPDVDALKKAAAKADEYLALAQRVQADFDNFRRRNEGVRADAFAEGQRKVATAMLPVLDNLERALAAAENADADALKTGVEMTRKQMVAAYEKLGVTPIDRLGEKFDPNLEEAIMQGTADDGEPGTVCMVLQKGYMMDKTVLRHAMVKVVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I941</accession>
    <name>R7I941_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48394">
        <property type="protein sequence ID" value="CDE48394"/>
        <property type="gene ID" value="BN770_01682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="239"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="493" mass="50995" checksum="831564C71A6448D5" modified="2013-07-24" version="1">MSEQNLKQVLAKKQSILQGDAERIAKQRAAGKLTARERVAKLLDAGSFVETDALVSRNGDYAGVVTGSGTVQDRPVYVFAQDFTVHGGAMGQMQAQKIVKVLDLAQKTGAPVIALCDSAGVRIDEGAAAMNAYASVFTRLAKLSGVVPVIALVLGPVVGGAAMIAQLADITIEAENVGQLMVYGPQVMSAISGKTVDAKAVGGAKAMAAQGGVALTAKDEDEAISLAVQVLDYLPGCNAEDAAIVDTDDMNRILPVLDAADAESQLAAMADGAAYVELFKDYGKEIRVALTRVGGRPVGLVVGNGKENDGVLTAQSASKAARFIRLCDCYSLPVVSLINSKGVAVPTVDEQAATIKATTQLLYAYAEATTAKVSIVTGNAIGQAYVAMGGKSNADVTYAWPGAVISALTPEAAVQVLYTDDLKADKKPALQSRAELEAKFAADVADGVAAAAAGMVDDVIDPAETRKYVIAALEMLSSKRESNPPKKHGNLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I954</accession>
    <name>R7I954_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48031">
        <property type="protein sequence ID" value="CDE48031"/>
        <property type="gene ID" value="BN770_01507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="235"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="356" mass="39655" checksum="B565DEDBD00F56A7" modified="2013-07-24" version="1">MNELYTANIALSVFAMAIMLFSLRGDISQSKIRNLLCGGLYATIAICALCEWSGVQMDGTPPALIPLHIAVKTIELSLAPLIGLFAGCVIHPCPRKVVHRLLCLAGFHALLVLLSAFTGLIFYVDGQNFYHHGLLYVLYMLAYGGSMVFFLVQIWFACRAYQYTGGTQLMLATLFVLLGLMVQLFLPTVKIDWITISCGALMMSKFSSDMVLQTDGLTQLVNRLGYEHYLARLRVPATILMFDVDRFKDVNDCHGHLMGDACLRTIANCIRRAYGNYGTCFRIGGDEFCVILTRRNAQYNTMTEIFQHLMDAARAENPVLPTVSVGCSHFHPSTDELADSLAQADAQMYQYKEAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9N8</accession>
    <name>R7I9N8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000093">
        <property type="protein sequence ID" value="CDE48295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48295">
        <property type="protein sequence ID" value="CDE48295"/>
        <property type="gene ID" value="BN770_01626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="25580" checksum="BABB860659BB90CD" modified="2013-07-24" version="1">MTGYSPRRRGSILSDMADIAQDLWASVPETVPAEKPTAVRDEPTAPHAPQTAQNPAKSADSAPKATYADEKSLPFTELWKVGDEPIDWTEVLSSPIPTDGLVSAEKWALYRQYAAKVLSGDTAAYLGVLKAVDPMGDLAPYTSSLSVATRDADVMLATFAVRDDLLDSDGEHYLCGLSLRIARDLFATLPVTHVIVTATQKEQPIKRVDFPRSAMQNARFQFVDPVTFVGQLKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAL8</accession>
    <name>R7IAL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48318">
        <property type="protein sequence ID" value="CDE48318"/>
        <property type="gene ID" value="BN770_01643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="276"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="491" mass="55352" checksum="3241EC22DDF81756" modified="2013-07-24" version="1">MRKNPKEKKHPRIRRRVFAYLAAFVAFVLALLWLMQIVWLDDFYRWDKTRQITQAADAVESNIGNAQLSALMDRLAQQNDVCILLLDSDKHVFLSSDDIHYCLIHRMSSRDLSFWCSMIPENGDTLTELFNIAPFGGDQYNSHQFRGNVPKMEDAKKQSLLCARRVTLPDGTDGYLLLNSIITPLDSTVATLRMQLMLITIIVLLGATLLAMLISRKVTRSIVETSEAAHSLSRGQYEIPPHGCEYREMAELNDTLVYAAKELSQVENLQHELIANISHDLRTPLTMIGGYVEMMRDIPGEATPENMQVIIDETQRLTSLVNELLDFSRLQTGALALNPAPYPFTASVQAITDRVSRMVQQNGYQVVFHPAAQVKAIADEQRIAQVVYNLVGNALTYTGEDKTVEIHQEVIGKMVRLTIHDSGKGIVPEELPLIWNRYYRTQETHKRAIIGSGLGLSIVRSILEKHNVPFGVDSKEGEGTSFWFELPLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAM5</accession>
    <name>R7IAM5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000112">
        <property type="protein sequence ID" value="CDE48546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48546">
        <property type="protein sequence ID" value="CDE48546"/>
        <property type="gene ID" value="BN770_00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="241" mass="27133" checksum="3A8DE453A17190A9" modified="2013-07-24" version="1">MSALPAQAESPEMADLLAEFYDGGAELPFGLTEDELTCVDGVLYGRDILLLYPKTRTNSCFVIPDGIGYVWDFAFMGNDSLEKVVVPDSCKILGACAFWECSNLAEVEFGANSELLIVDDFCFSECYALQQIRLPDSVYLIGEAAFSYMPLHQFVFPEKIVFIGDQLFWGTPVTELTFHAWSLPQYIGSEYFSIDDDDAEYRITLPFDADADRYLGNAEYVMQKENVTVLFCEDTDMPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAS6</accession>
    <name>R7IAS6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopentomutase</fullName>
            <ecNumber evidence="4">5.4.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphodeoxyribomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoB</name>
        <name evidence="6" type="ORF">BN770_01739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphotransfer between the C1 and C5 carbon atoms of pentose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27658"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-ribose 1-phosphate = D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:18793"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 or 2 manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphopentomutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48596">
        <property type="protein sequence ID" value="CDE48596"/>
        <property type="gene ID" value="BN770_01739"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16009">
        <property type="entry name" value="PPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00740">
        <property type="entry name" value="Phosphopentomut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024052">
        <property type="entry name" value="Phosphopentomutase_DeoB_cap_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001491">
        <property type="entry name" value="Ppentomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143856">
        <property type="entry name" value="SSF143856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01696">
        <property type="entry name" value="deoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="2"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="387" mass="41960" checksum="B04CF11884FCDDAA" modified="2013-07-24" version="1">MKRIFLTVLDACGVGELPDAADYGDVGACTIGHAVDACHPSLPNMAHMGLGQIAGAHYPADENAVGAFGMCREASKGKDTTTGHWEIAGVTLAKPFPTFPNGFPADFIAAFEQRIGHKVIGNKPASGTAILDELGEEHLAKRTPIVYTSADSVFQIACNEAIFSREELYEMCRIAREMLTGDLCVGRVIARPFVGEKAGAFQRTSGRRDFSVEPFSRTLLDAVKDAGMESYGVGKIEDIFALRGLTGSNHAAGNPACIEAWLDYMRKPFNGLCFTNLVDTDMLYGHRRDPQGFADALAYFDSKLPEIIDLLGDEDLLVITADHGCDPTFKGTDHTREHIPLLVYHKGMKGLTDLGVRKTYADIGATCAEWLGLPDRFGATSFMDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAV9</accession>
    <name>R7IAV9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000118">
        <property type="protein sequence ID" value="CDE48705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48705">
        <property type="protein sequence ID" value="CDE48705"/>
        <property type="gene ID" value="BN770_01791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="32" mass="3531" checksum="ADD011D8289D0B8D" modified="2013-07-24" version="1">MNVVVRETEPPCKATDLELLGLVEVYSPALML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAX7</accession>
    <name>R7IAX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter small conductance mechanosensitive ion channel MscS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49059">
        <property type="protein sequence ID" value="CDE49059"/>
        <property type="gene ID" value="BN770_01904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="348" mass="38394" checksum="9DE603C738195945" modified="2013-07-24" version="1">MTPEVQHYLLAGFLLLAAVFAVPLLKRVLTPVKKRINDRIPALVGHLLRCFLRPAAWLVRVTLAGWALLTIPWSAEIRVVLTRAMPYYQAFVLAMAAWGVWEAIPVIWQMLHRHPHPDQPENYETLSRFFENGCRTVVVVMAVLVGLDGLGVPVTSLIAGAGVVGLAITLAAQSTLSGLIAGITLVAEHPFSLGDYIVLGDVEGTVEDISLRSTRIRTPDQVLITVENSKVCAEYIQNANARTQRLWVFTIGLEYRTSAPQVEQFIRDLTKLLVSDPDVDGQSVQAVLEEFADSSINVNVRMMVNTPGYGDYRALKGRINLAVMNLMAEEGLSFAFPSRSVYVEKNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB29</accession>
    <name>R7IB29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48755">
        <property type="protein sequence ID" value="CDE48755"/>
        <property type="gene ID" value="BN770_01810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="266" mass="28385" checksum="01AFADD6BC71371D" modified="2013-07-24" version="1">MGFLAGKTAIITGAGYAKLSNGRCGSIGYGIATAYAKEGANLVITGRNVKKLTDAKEELERLYGVKVVCVQADVNDSADNEAVVNNVVKQAIDTFGRIDVLINNAQASASGVPLADHTTEQFNLALYSGLYATFYYMKACYPYLKETKGAVINFASGAGLFGNYGQCAYAAAKEGIRGLTRVAATEWGKDGINVNVVCPLAWTTQLENFQKAYPEAFKANVKMPPMGHYGDSEVEIGHVCVQLASPDFKFMSGETITLEGGMGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB63</accession>
    <name>R7IB63_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoU_methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48805">
        <property type="protein sequence ID" value="CDE48805"/>
        <property type="gene ID" value="BN770_01824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26662" checksum="605C2E38EACD1C88" modified="2013-07-24" version="1">MPSLSTYSAELDYAYAPGMFPAMECLLHRPESCRRVLLHSRSAGTEGAQRLREEAEKHHIRVEEADKALSRISGKDNCFAAAVFSKFEDDLNPNKPHIVLHHPSDSGNVGTIFRTALGFDVQDIAVIRPCVDVFDPKTVRASMGSIFQLRLHVYDDFSQYQAQFPEHALYPFMLDGSKSLPDVLGDIPDRWTLIFGNEGSGLPPEFSRLGQPVRIPSSNKVDSLNLSIAAAIGIYAFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB99</accession>
    <name>R7IB99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein dnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48741">
        <property type="protein sequence ID" value="CDE48741"/>
        <property type="gene ID" value="BN770_01800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="182" mass="20846" checksum="3E7EEF62B7EFF955" modified="2013-07-24" version="1">MRNPFGVLGLEASADADQVRAAYRKLVKTCHPDKFQDETERKAAQEKMITLNLAYEEAMKLAVNRTTASAAFNRELDQQDALTLAAKMLRQDNPEAALRQLLRASTRDSAWYAMQGKVLMALEQYESAHQSYREAIRREPNNNLYRQGALDAAVALKKSRTPWGRIQKLIRRWKKEHGGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBA9</accession>
    <name>R7IBA9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ORF">BN770_01741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48598">
        <property type="protein sequence ID" value="CDE48598"/>
        <property type="gene ID" value="BN770_01741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="102" mass="11177" checksum="A5F95FAC1DA65920" modified="2013-07-24" version="1">MYAIISAGNKQYKVSQGETIYIDKVNQADGSAISFDAIMVVNEGDVKVGTPTVAGVTVEGKIVGQVKGEKIKIYKYKSKKNYHRRAGHRQPYTKVEITAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBH0</accession>
    <name>R7IBH0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000126">
        <property type="protein sequence ID" value="CDE48935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48935">
        <property type="protein sequence ID" value="CDE48935"/>
        <property type="gene ID" value="BN770_01873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="139" mass="15682" checksum="47A593A9B1FE6326" modified="2013-07-24" version="1">MQNGSWNVLFLSADKDWNPVNGQTYQLKLGRFDSTQVSATVESFSRSGGELLVRLRVESDVHPVLYMRSTEATLGENMDTFRVPERALYVQNETQGIVVVEGQTESFHPISVLTKADGYIYFQPVQQGLLYEGLTVKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBL3</accession>
    <name>R7IBL3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000122">
        <property type="protein sequence ID" value="CDE48871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48871">
        <property type="protein sequence ID" value="CDE48871"/>
        <property type="gene ID" value="BN770_01849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="176" mass="20253" checksum="00DF6114C00C4B17" modified="2013-07-24" version="1">MKKAASAFLRMEICHADITRMIRWMRNPNVTKYLNEAPDVARSLEELVQSVPEPMYQYHLCRTGHFFMVCHQENESVGFVKLLPTAMEGAYEIVYVIGEDALWGHGLGQQAVRSALSKAFLHLRADRVVAKVMPQNLRSIRCVRACGFQQMAEMPRLVRFEITFDAYCQALREKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBP8</accession>
    <name>R7IBP8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Colicin V production protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49015">
        <property type="protein sequence ID" value="CDE49015"/>
        <property type="gene ID" value="BN770_01891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="25301" checksum="7449B83DBE4D7D80" modified="2013-07-24" version="1">MNIVDYVIIGIIGISVLFGLYRGFIASVLNMGCGLMSFLASFWVSPKLAAAVQSNQSFLNMLLHYTDASSRIGDLETAITNVATLTSQSINSILEKVNLPAPLDTLLRVNLENNVYASSGLSTVSDYVSQTILQASINIICFLVSFLVLYIVLAIVLNLLKAVFRFPILKQLNGLAGGAFGFLRGLLVCLVLFTLVPLVQTVIPLDMVNDLIAQSTLAPIFSNGNLILAIMNGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC06</accession>
    <name>R7IC06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48818">
        <property type="protein sequence ID" value="CDE48818"/>
        <property type="gene ID" value="BN770_01837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="34"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="313" mass="34266" checksum="359B8D19DE9E6EE2" modified="2013-07-24" version="1">MQPRQMIQRLMNNISTVIVGKQEVIEYALIALLCRGHVLIEDVPGVGKTTLASALAKSLDCTFRRIQFTPDLMPSDVTGYTLVNFKTGETEYREGSVMSQVVLADEINRTSPKTQSALLEVMEEQQVTVDGVTHPVPQPFIVLATQNPGEFVGTYPLPEAQMDRFFLRLSIGYPTIEQEMDVLERYSGVVKPMATLSPVCSAADVIAMQEMVTQIYCSPEVRSYVATIAAATRQDAALQLGASTRAAIALIHGAQACALLAGRDYIVPEDVQHMAVQVLAHRLVLSPEARMKGVTPESVVRRIVQNTPVPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICS0</accession>
    <name>R7ICS0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="9">DHOD</shortName>
            <shortName evidence="9">DHODase</shortName>
            <shortName evidence="9">DHOdehase</shortName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrD</name>
        <name evidence="11" type="ORF">BN770_00150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="9">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000135">
        <property type="protein sequence ID" value="CDE49103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49103">
        <property type="protein sequence ID" value="CDE49103"/>
        <property type="gene ID" value="BN770_00150"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="10">
        <location>
            <begin position="6"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="71"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="303" mass="32497" checksum="ABA7726D3E5E3BD9" modified="2013-07-24" version="1">MSSKDLRVTLSGVTLDNPVIPASGTYGFGQEFTPYYDINILGSLSFKGTTAESRFGNPTPRIAECPNGMLNSVGLQNPGVEHVIAHELPALRKIFHKPIIANISGFSVEEYVHCVELLTKEEQVEILEINISCPNVRHGGMAFGTNPDAAAEITRAVKQVATKPVYMKLSPNVTDIVSIAKACEEAGADGLSLINTLLGMRIDLKRRRPVLANVMGGYSGPGVFPVAVRMVYQVTGAVSIPVIGMGGVSSAQDVIEMMMAGAKAVQVGAANLTDPYACKKIIDDLPREMERLGIERLSDIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICW4</accession>
    <name>R7ICW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000101">
        <property type="protein sequence ID" value="CDE48372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48372">
        <property type="protein sequence ID" value="CDE48372"/>
        <property type="gene ID" value="BN770_00132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="131" mass="13986" checksum="6CC85AC65AA6E57F" modified="2013-07-24" version="1">MKKTSIFATVTALAALVIYLLTSLTGFMAGKAMNICPVVLTVAAIVLLFAADKMKKPSALKDIVIVLTGFALIGCISFFAMNRVKLAADVWFIPVNRPATEDVALYCSLAGVALYLISFVTVTVKAFSCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDB5</accession>
    <name>R7IDB5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Aspartate--tRNA ligase</fullName>
                <ecNumber evidence="12">6.1.1.12</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">Aspartyl-tRNA synthetase</fullName>
                <shortName evidence="12">AspRS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
                <shortName evidence="13">Asp/Glu-ADT subunit C</shortName>
                <ecNumber evidence="13">6.3.5.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">gatC</name>
        <name evidence="12" type="synonym">aspS</name>
        <name evidence="15" type="ORF">BN770_02142</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 13">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the GatC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="12"/>
    <dbReference type="EC" id="6.3.5.-" evidence="13"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49794">
        <property type="protein sequence ID" value="CDE49794"/>
        <property type="gene ID" value="BN770_02142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="143"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="12">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="537"/>
            <end position="540"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE49794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="692" mass="78996" checksum="9739C23556DA5D98" modified="2013-07-24" version="1">MKRTHYCGAIRKEHMGQTATLCGWVQNRRDMGGVIFLDVKDREGVAQVVCNMQYLPPEDFHHAETLHMQSVIQVEGEIRHRDEETYNPRLATGEVELLAKRLVVLSEAQPLPYSMDEDAKVREELRLKYRYLDLRRPQLQKALRFRHQVQMAAEKYLNGDGFTCIETPMLCKSTPEGARDYLVPSRVHPGKFYALPQSPQIFKQMLMVGGMDKYYQVARCFRDEDLRADRQPEFTQVDMEMSFVEQEDILQHLERLFKSIFRDVMGREIGYDFPRLTWQESMDRYGCDKPDLRFGMEIRDVTDLAAECSFSVFRRVADEGGKVRALNCKGCAEKFTRTTIETLTDHALGYGAKGMAWILIHDSGEVNSILQKYFTKAQWQALLTALDAQNGDFILFCADKFQTVCRTLCGLRLEVGDMLGLRAKQDYRFCFVTDFPEFEWSDEEQRYMAMHHPFTMPYEEDLPYLMTDPARVRSQAYDVVLNGIELGSGSIRIHRPDVQALMFRALGFTEETARARFGFMIDAFKYGTPPHGGFAFGLDRLVMQLLGADSLRDVIAFPKVRDASDLMTSAPDFVDAEQLEVLQLGVSTAAEAEKHPQKKRPTMAIKTVAELAKLSLTAEEEVTMGEELNTILGFAEALQEVDTTDVPQTAHVIPTENVLREDIPAAPFDRDLLLSNAPTRTEDCVNVPQTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDK6</accession>
    <name>R7IDK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49705">
        <property type="protein sequence ID" value="CDE49705"/>
        <property type="gene ID" value="BN770_02091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436432" evidence="1">
        <location>
            <begin position="22"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="395"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="616" mass="69743" checksum="ECA0BF94D3DC46E1" modified="2013-07-24" version="1">MRKLTCMRISAKMTILFSVIAACMIAVNSVLATLSEIQNILLYEEDNLNAMASKIVAAFEQNITVMGYALDGLKQDNDFMAALNTIYTLGEDMETTSEYHQAQNTLSAALFHEPLNDYFYRINVLTMDGFYLSSRYETIGLLENYSDELRTVMLRLPYLNERNRGLSQKTLVRPHIDPWFVARPISIYTLMSPAVYHGKQIGFVEVNALSTDLFDIFSSNDMAGFRATAYDADGRLFHRNFDDTIDYSAAEYGSMTECSDKNGDTYYVVKEHCSWLGFDIYAAQRTAVFESSIHSVILHHVLVSLLVLFIAEVFIILSSHQLSRSILRLTRKVSQLSDPAAIAERPLLPEEMPKVTNPHDVEMRELEDVFDKQVMELKTAMRNDAELRESNLRSRLNALQAQINPHFIYNTLNIISAKSMEAGNEEVIDICGKFARMLRYSTDLRSKTATLQEEIAHVRNYLALAKARLEDRLEYTIDIPDAFSHLTLPKLSLQPIAENAISHGYQGSSGTIHITISGTVDEDGCLHLLICDDGCGFGEEILSHLREEFSHIEAGELTEPENTSAHIGLVNTYRRLFYFSRGAIRMRVRNDGGAVVELIETRTSEEEDDVHHSDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDM5</accession>
    <name>R7IDM5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="10" type="ORF">BN770_02102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49720">
        <property type="protein sequence ID" value="CDE49720"/>
        <property type="gene ID" value="BN770_02102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="408" mass="45624" checksum="1C3A0B127D7FE89B" modified="2013-07-24" version="1">MHILDVLKERGFIAQTTFEDELYKQLEEPTTFYVGFDPTADSLHIGHYIPIMAMAHMQRAGHRPIALMGGGTAMIGDPSGKTDMRKMMTVETIDHNVECIKQQMSRFLDFSDDKAIIVNNADWLRNLNFIEFMRDIGAMFSVNKMLTADCYKTRMATDNGLSFLEFTYMLMQSYDFLELFHRYGCRLEMGGNDQWSNMLGGADLVRRKDSEKAFACTFQLLLTHDGKKMGKTEKGALWLDPNKTSPFDFYQYWRNVDDADVEKCLGLLTFLPMDEVRRLGALQGSEINEAKKVLAFEVTKLVHGEEEAQKAADAAAALFAGGASAANVPSFTLTKDEFAADSRVTTMLVKSGLCKSQSDARNQVKAGAVLVADKKVDDLNATLAESDVPADGLLIQKGKKNFRRLFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDP3</accession>
    <name>R7IDP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MazG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49433">
        <property type="protein sequence ID" value="CDE49433"/>
        <property type="gene ID" value="BN770_02013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11723">
        <property type="entry name" value="YabN_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035013">
        <property type="entry name" value="YabN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TP_methylase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="252"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="386"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="495" mass="55729" checksum="B45EADC6B15A6ED5" modified="2013-07-24" version="1">MKQNITVVSLGPGDPELLTAQSLNTMKKAKRLIFRTAQHPVYAVLTEAGVQSTSLDDYYDRYEDFDEMHRDMAKALWAEAEHHAVVFAVLDAGTDGAVRELRAQQPQDAVLRILPGVTLADACIAQLPGNLAPIGALRTIPAEDAVTAAADPTTPLLITEIWNRSLACDLKLRLCDIYGDELPTVLFPSTVKTNRKPQNIQLWEMDRLHTYDHTVCLYLPAVPLQQRTRYSFQDLQHIMHQVRRQCPWDREQTHQTLRRYLIEEAYEAVGAVDEGDMDHLADELGDVLLQVAFHADIAESAYEFTMQDITTAIVHKMLYRHAHIFGNVHCDTPEEVADSWEKLKKAEKGLMSQGSVLADVSKSLPALMRAEKVQKKAAQVGFDWDTPQDALPKVHEEADEVLTELQNARDPGEELGDLLFSCVNVARLSGIDPEQALKNAIEKFIKRFSAMENLIKLDEKSLKDLTLSEMDVYWNRVKAAQNRAVEPSSPADWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE27</accession>
    <name>R7IE27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IMP cyclohydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000154">
        <property type="protein sequence ID" value="CDE49870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49870">
        <property type="protein sequence ID" value="CDE49870"/>
        <property type="gene ID" value="BN770_02176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020600">
        <property type="entry name" value="IMP_cyclohydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036795">
        <property type="entry name" value="IMP_cyclohydrolase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07826">
        <property type="entry name" value="IMP_cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75569">
        <property type="entry name" value="SSF75569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP_cyclohyd" evidence="1">
        <location>
            <begin position="15"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27405" checksum="1B49B23F1D835054" modified="2013-07-24" version="1">MKKQELNDVLSNNTYPGRGICLGVDESGEYAVIVYFIMGRSVNSRNRIFEETDDGIITKAHDESLMTDPHLIIYAPVRALPGGEYTIVTNGDQTDTVYDFMQNGQTFEDALRTRTFEDDRPNWTPRISGLVRVADGKASYKLSIIKSDDGDENSVLRYFYEYAQPKAGEGHFIHTYQCDGNPIPSFAGEPEKVALHGDIEQLALDTWMNLNEDNKVSLYVSYISLADGSSDTIIINKHDQEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE69</accession>
    <name>R7IE69_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02052</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49618">
        <property type="protein sequence ID" value="CDE49618"/>
        <property type="gene ID" value="BN770_02052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="72"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="133"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="360" mass="39916" checksum="1D4975A4C2C7F121" modified="2013-07-24" version="1">MKQQEKGRGKLDIRALFTLAAIAEILGTLLIATLLTALLENLLHEAIEVHPLVWLLLFGTTIGLTAATVVNVLLLRPVVRLSRAMKQVASGNFAVRLTTNSVINEIADSYDSFNRMVEALGETETLQTDFVSNVSHEIKTPVSAIEGYTTLLQSTDVSPEQAGYIERILLNTRRLSTLVGNILLLSKVSNHTMPMKQTCYRLDEQIRQAIVLLEAQWSPKQLDFDADLAEVTWRGPETLMLHVWTNLLSNAVKFSPQHGLIAVALKQTDGRFEIAITDQGPGIPPEEQERIYRRFYQVDSSHQQEGNGLGLALCKQILDDCGGTIREENQSPCGCRFIVTLPEKMTGEEAKQEEAHGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE99</accession>
    <name>R7IE99_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Beta-galactosidase</fullName>
            <ecNumber evidence="3 9">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_02076</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 9"/>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49653">
        <property type="protein sequence ID" value="CDE49653"/>
        <property type="gene ID" value="BN770_02076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436461" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="domain" description="Bgal_small_N" evidence="11">
        <location>
            <begin position="1288"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1589" mass="177475" checksum="D2CA05A1898A40DC" modified="2013-07-24" version="1">MRKWLIGLLMILGLCAGFAQAETYVVAVDGTGDFQTLTEAAAASSTGDTILLRAGVYGEQETFPIALDHAVTIESEDGAVLDSPRFKTMLSVTADGVTLRNIRFQVRKWGIVADVNREMTVEDCEFVLGDEECRTSSTAIWLRGMKECAIRRCTFRQVGICIAGDPLSDKSAGKTVLTGMCEAGEDPEYFSTHEIADCTINGRPYYYFVGQDNLTVPTDAGGLIAVECDNLTVRDIDVSDSSMGLEIARSRNVTLENVSADRCGIFGTYLVFVQDAVLRNVHVEQTNHGIDIRGSQNVVVTDSLALNCDQGVFFTHCTDCTLQDSHVQGCGFGYFGAVGNGNRIENCTFSDNADGIYLQNEPNATITACDVRQSRVTGLRILKSSCVCTDTTVADGWTGVIYYDSHDTTIENCDFSDNASANMYLGNGRGATIRNCRFSGETKAHLEVEGTQTDMLVTQCTFTGSRADMLKAASHTLPTFTECAWSTPGVFWTGKEWNGSTDGDAPNRNCDIVQIGREAPRTDSVPYDTPEQAIDGAVNYRKENSGRYLLLSQTNWTFRLFDSPSEFDRGGCVNFYQPDFDASDWANIFVPSVWQTQGYDHPIYTNTTQKFARNFGNKIGYPADLPMAPTTYNPIGLYRRTFTLPESWSGERIFLTFEGVDAAFYLWMNGTQVGYAEDSFTADTFDVTDYIRYGEENTLAVKVYRWCDGSWLEDQDYFDLSGIFRDVYLYATPQTFVRDYSLVTDFDADFADSTFSVTLMLENRGDADGEICVSAQLYDADGQPVAWTADAAHAILSAGEAQSVTLSGVVKTPRKWSAEDPYLYTLVLAETSGEETVYESCQVGFRKMTYKTNASGWFEGSTGDADLIRINGQPISLRGVNRHETHPEYGYAVTREVMEIDIRVMKENNINAVRTSHYPNSPYWYYLCDKYGIYVVDEANLEVHSNMIYENARITEYMSNAIIDREYNMVNRDRNHASVIMWSLGNECKNPEILRTILVQPYVNQMGETHVLHAYDSTRPWHYEQARDNFSTGIDVYSGMYETVEQMIAYAEAGHDTPYIECEYEHAMGNAMGNMDEYQAAFDTYRSLQGGFIWDFIDQSIYQTAEDGTRYFGYGGDFGERVHDDNFCANGLLLPDRTLQPEMAEVRYQYSQLKFDAFDEDHATVRMKNYFLFTDVAEKYEFRWSITADGDVAAEGVLSADVVRVANVDARTNQPGERVVTLNLPTIAKEAGKEYFLNLTVALKAQDGLLNAGHVVAYEQFAMRNDNELTSMLPDTAMTVTQDGNVLSISGEQFHTALNLETAQLRRYEALGADGTFHALIVPGEGPKGSFYRAATDNDRAFGSGLGHMNAAWKEPGMYVVTNRALYTDENPVRVTFDGCYPALENMLVSLEYRFYGDGSIRVQMHLSAPEHQQLIYIPVVGMQMTLPKAYERMTYFGCGPEENYTDRHSGTKVGCYETTVTDNFFPYMEPSETGNRTGVRWIALTDETGEGLLAAADSAPMEASALHYTPEALTQAKHPYQLTATENVILRLNAVQIGLGGDNSWYRIIVHEPYLTPLTRDYDYAYILSPLSAKEDAMEKARTIRNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEB1</accession>
    <name>R7IEB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48917">
        <property type="protein sequence ID" value="CDE48917"/>
        <property type="gene ID" value="BN770_01857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448201" evidence="1">
        <location>
            <begin position="20"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="734" mass="78885" checksum="3D481109334308E1" modified="2013-07-24" version="1">MKKLLCLLLTLLLIHPALAEDALDAPDASSLLPCANGALLAVSPDLRVLRRDTAGNWALVLSAEQISAACPPRFMPDAANALLLPGENGAYALLLLPDTSGQIAVLSLTGATCELTRVFADFLPTDSEMAAQWTLLSAARAGNTLYAAFSSNFATYSTYALSLADGSSFLLSDAPIRFLMPLADGQLLACVNPPISSIDETCFALLDADSGESSRLCALPAHKAYAGFALDGDSLYFTDGETIYCAAPPYDAVESVGYLPSLDTSARLPALMVDNCYCVCNAELGFFAAQLHTAPRCTLRVDTRLSNVNRALVSQYLRAHPDVAVVYAPHNASTAPEYRQHMESGDALDIYAFTLPNESFIPLRDKGDLLDLRPLMGADTPDSLLPQVLAPLEKAGGLFAIPCGAPSVSCWFLDQSSLESLGLTDVPATYADLMTLISTYLTDFASDSDVALADNPGGMADSLFQQLFWAQLARCEASGVLPTFTDADFVAALRQYIALRPALVDYETRWLAERSSSLGDLSDTGGIVTVLSVSSSQPSLLHLNTSLTPSKTDEVPLLLSFSEGGALLIPMTYSVLAVNRRSAYPDDAASLLSYLLDNQPYDAKLALLPDYAVLQPNPAYTEAAQKILDDEALYMQYRATLSPLEQKQAEDILADARAALHQIPPNVYSAAEIATYHARLNHAHLLESSFWVSGDQHVSTLRQRLLDGECTVETFVQELTRIVQMMTLENGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEB6</accession>
    <name>R7IEB6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50164">
        <property type="protein sequence ID" value="CDE50164"/>
        <property type="gene ID" value="BN770_02307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="296" mass="32349" checksum="25BCE459058F6453" modified="2013-07-24" version="1">MAVFLQVITLFLLIFCGFFSAKGKLVDENGISTLNKIVLYFALPALTLYGLQKDASPELIHDLILVFFISLAIMILSGLIAYFLYRSEPNERRSVLTNLSMLSNSAYMGYPVVIATLGEDMLIYAVVFVGAFNLMCWTFGSFFFGGISAIQPKKLLTNPSLIAVLVGLVLFLTGWRLPGFINDALSMMGNVTTPLAMFVIGARLIDLRFAHLQDWKLLLACALRLIIFPAAVLLLRFTGLPAAVVSVLYICTAMPCAATTAMQSEMYHCDNSLASRGVALSTAFSILTLPLMLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEC1</accession>
    <name>R7IEC1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">BN770_02118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49751">
        <property type="protein sequence ID" value="CDE49751"/>
        <property type="gene ID" value="BN770_02118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="200" mass="22462" checksum="A5B7D8EC2F427347" modified="2013-07-24" version="1">MSEARKGMLLVISGASGTGKGTVIKELMAHDDSLVFSVSATTRSPRPGEENGREYYFISEEEFARRVENDEFIEYAPVFAHHYGTLRSEVSRRLAQGQNVVLDIDVQGAEQVIAREKDCVSIFILPPSMSELHRRLEGRGTESPEQIAMRQEIAVREIALKNHYRYNVINDDVAACAARIAGIIEAERYNTARYTVEIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IED7</accession>
    <name>R7IED7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylalanine--tRNA ligase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48947">
        <property type="protein sequence ID" value="CDE48947"/>
        <property type="gene ID" value="BN770_01879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="108"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="194" mass="21114" checksum="692E686C80A2284E" modified="2013-07-24" version="1">MGALLRKRKVTGRDASLPARLRDMLCVAVSDILHKDLSFHAMTATHSYEHPKNLNAIVLDGVDLGEIGVAHPVVGKNIDKKAAIVFAEIDTEALAAIAPAPIVYREPSRFPGMEQDLTFVVNRCQPILDAVKAENSPLVQKVTVLGTYSDITGKTITIRLSFSHPERTLTRDEVQAVVDGVVARLKGQGIELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEN3</accession>
    <name>R7IEN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49773">
        <property type="protein sequence ID" value="CDE49773"/>
        <property type="gene ID" value="BN770_02127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="606"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="696" mass="76574" checksum="3E6FD5804E8A82DD" modified="2013-07-24" version="1">MMNRDEARRLAHELVAQMTLEEKASQLRFDSPAIPRLGIPAYNWWNESLHGVARAGTATVFPQAIGLAAIFDEDFHEMVASVISTEARAKYNGQSAHGDRDIYKGLSMWSPNINIFRDPRWGRGHETYGEDPYLTSRLGVRFIKGLQGNGKYLKVAACAKHFAVHSGPEAIRHSFDAVANPKDMNETYLPAFEAAVKEAKVESVMGAYNRVNGEPACGSKTLLVDILRNKWQFEGHVTSDCWAIRDFHEHHHVTDTAPESAALALKNGCDVNCGNTYLHMLTAYQEGLVTEEDITTACERMYTSRYLLGCFADDCEYDKIPYTANDTDENDALALEAAEKCMVLLRNDGVLPLDAGKIRTIAVVGPNADSVPALEGNYNGRSSRYVTFLEGIRAYAEEHGIRVLFSEGCHLFKDRVQNLGQPNDRLAEAELVAENADAVIACVGLDATLEGEEGDTGNAFASGDKISLNLPESQQKLLDALVKTGKPLVTVVAAGSALNVPQGNAEIMAWYPGQAGGTALAEILFGEVNPSGRLPVTFYHDLSELPEFTDYSMKNRTYRYFEGKPLYPFGYGLSYTTFALDNEAVDAEMGWVTATVENTGDRDGETVVQVYVQDVDTKWETLHPHLAGFARVALKAGEKRQIAVPLDKNAFTVVNDAGERVADGKVFDVYCGLYQPDERSAELTGQTPVKMTIRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEW2</accession>
    <name>R7IEW2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50155">
        <property type="protein sequence ID" value="CDE50155"/>
        <property type="gene ID" value="BN770_02302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447894" evidence="1">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="187" mass="20781" checksum="356EF5B1D452A49F" modified="2013-07-24" version="1">MKKLFSLLLVLALALVPTLSLADDDAACQNLYNMLLDELKSVDLEMTADEESYRIYLGSALDKNSLGDADVIFDAYSDAVTINVSYSNPLDEALVPQVISFFNRVNSTLYVGKLMVIKSDNVWYAAYEIFLSVDPENITDWDRNNVLAYTALALDTMEEMVDYITEIANGESADNVFAMWQADIGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF30</accession>
    <name>R7IF30_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ORF">BN770_02374</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50409">
        <property type="protein sequence ID" value="CDE50409"/>
        <property type="gene ID" value="BN770_02374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="179"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="232"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="444" mass="49887" checksum="13AAF2D94A69EFD7" modified="2013-07-24" version="1">MAKPLVAIVGRPNVGKSTFFNRIAGKRISIVEDTPGVTRDRIYADVEWQNRRFTLIDTGGIDPHSDDVLLSQMRRQAEIAMDTADVICFFADGRDGLTDDDREVANLLRKTKKPILLVVNKVDHISMNDNIYEFYELGLGDPIAISAANMLGLGDLLQAICEKLPPADKDEMDETEHILQLAVVGRPNVGKSSLVNRLVGSERTMVSDIAGTTRDAIDTLFTVNGTQYNIIDTAGIRRKRAVEDETLERYSVLRSIAAIRRCDVALLLIDAQDGVTEQDTKIAGLIRDEGKAVIIIVNKWDAVEKETGTLEQFRKEVLDALKFMDYAPVLFLSAKTGQRVHTVIDMVDQVWAQTSKRIPTGVLNDVLNDATADLQPPATNGRRLKIYYITQQSACPPTFILFVNEEALMHFAYQRYLENYFRKTFDFTGTPIRFILREKTKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF87</accession>
    <name>R7IF87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase YfbR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50126">
        <property type="protein sequence ID" value="CDE50126"/>
        <property type="gene ID" value="BN770_02291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="198" mass="22594" checksum="46B0B115DC51B65E" modified="2013-07-24" version="1">MIHHFFAYIARLRYIRRWGLMRSSMSENDAEHSLQVAMLAHGMALIGKNRYGRDCNPEHIVTLAVYHDASEVITGDMPTPVKYHSLELRGAYKDVEKMANDRLLAMLPEDLRKCFAPYLCEGRDYDHQIVKAADSLSAYLKCVEERRAGNHEFDAAGEAIRRQLDAITLPEVQDFIREFVPSFSLTLDELNQPGGHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFC6</accession>
    <name>R7IFC6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_02244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50043">
        <property type="protein sequence ID" value="CDE50043"/>
        <property type="gene ID" value="BN770_02244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="259" mass="29465" checksum="3DB1B8CF8CCF5C45" modified="2013-07-24" version="1">MAWGKVDLCGLDTSKLPVLTPQRMQELYPLVHSGDKAARDEFIQGNLRLVLSVIQRFSGRGENVDDLFQVGCIGLMKALDNFDVSQNVRFSTYAVPMVIGEIRRYLRDNNAIRVSRSMRDTAYKALRARDRLQTELSREPTVEEIAADMHIDRMDVVLALEAIQDPVSLFEPVCSDGSDALCIVDQVKDERVRDEDWVQDIAISDAMGHLNEREKKILRMRFFEGRTQMEVAGEIGISQAQVSRLEKHALMNMRKHLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFF7</accession>
    <name>R7IFF7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylate kinase</fullName>
            <shortName evidence="8">AK</shortName>
            <ecNumber evidence="8 10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adk</name>
        <name evidence="12" type="ORF">BN770_02433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="8 10"/>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50544">
        <property type="protein sequence ID" value="CDE50544"/>
        <property type="gene ID" value="BN770_02433"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="11">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="8">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE50544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="207" mass="22653" checksum="77979FD8AC1158DD" modified="2013-07-24" version="1">MNIIFLGPPGAGKGTQAQRICNALNIPQISTGDILRRAIKEQTPTGLKAKSYIDAGKLVPDDVIIDIVRDRLAQDDAKNGYILDGFPRTVPQAEALEGIADIDAVIDLDVADEKLIDRLSGRRVCLKCGATYHISRLNGKTKCDSCSDELVQRADDKAETVLNRLKVYHDQTAPLVDFYQKKGLLRVIDGDQDMDTIFASIMAIVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFS0</accession>
    <name>R7IFS0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">leuC</name>
        <name evidence="8" type="ORF">BN770_02407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50470">
        <property type="protein sequence ID" value="CDE50470"/>
        <property type="gene ID" value="BN770_02407"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011823">
        <property type="entry name" value="IsopropMal_deHydtase_lsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02083">
        <property type="entry name" value="LEU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="424" mass="45083" checksum="F666E47EBB07C26E" modified="2013-07-24" version="1">MGMTMTQKILAAHAGLPEVKAGDLIEAKLDLVLGNDVTTPVAVSVFDKAGFTRVFDKDKIAIVLDHYTPCKDIKSAQLCKTARDFARRFQITHFFDVGQVGIEHALLPEKGIVAPGELIIGADSHTCTYGALGAFSTGVGSTDMAAGMASGENWFRVPSAIKVVLTGKMRPYVSGKDVILHLIGLIGVDGALYKSIEFTGEGVKNLTMDDRFTIANMAIEAGGKNGIFPVDEKTVEYVFGRVDRPWTAYEADPDAEYERTVEIDLSALEPTVSLPHLPSNTKVVSEVKGLPIQQVVIGSCTNGRISDLRQAAEILKGHHVHDGVRCIVIPATQQVSLDCIKEGLTEIFIEAGCAVSTPTCGPCLGGHMGCMCEGERAVATTNRNFVGRMGHVKSEVILASPAVAAASAIMGCVADPNDIAKEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG23</accession>
    <name>R7IG23_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">BN770_02445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50580">
        <property type="protein sequence ID" value="CDE50580"/>
        <property type="gene ID" value="BN770_02445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="91" mass="10587" checksum="522482AB3CEA2A27" modified="2013-07-24" version="1">MSETNNTQERGLRKTRIGVVVSDKMDKTVTIQIKTRVRHPLYGKIMNQTSKLKVHDENNECGVGDTIRVMETRPLSHDKRWRLVEIIEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGD5</accession>
    <name>R7IGD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic acid binding OB-fold tRNA/helicase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49642">
        <property type="protein sequence ID" value="CDE49642"/>
        <property type="gene ID" value="BN770_02070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448261" evidence="1">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="437" mass="46671" checksum="8786629602D847F8" modified="2013-07-24" version="1">MKKFLAMLMLLAMCFSCAAMAETTDEDLAAAKTYLFMMYKDLPETTMSDYEVVGVINIGGIEFPITWTADSDTIKIVPQDNKMVTIDVDEKNPEEVTYTLTATLSNAAGETVSVSFAHKVPAAMILEGMSYEEIVAAAYSLEAGLALEDTQRLYGTVTKIDTPWSDEYKNITVTIQVGELADQPIQCYRLTGEGAENLQVGDAITVEGILKNYKGTIEFDKGCVLVGYGEIVSQKAIVDAAYALESGVAMTAPTALVGEVVSIDSAWSDEYQNITVTIVCDGLTEQPIQCYRLSGEGAQALEVGSVVGVYGTIKNYKGTVEFDKGCVTVPADSVASVRLAVSAYALEAGLSMNDASTMTGVITSIDTAWSDEYKNITVTIVPGGLTDYAVQCYRLSGEGAETLAVGDTITVSGTIKNYKGTIEFDKGCTLDAVVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGZ2</accession>
    <name>R7IGZ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="7" type="ORF">BN770_00229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000181">
        <property type="protein sequence ID" value="CDE50870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50870">
        <property type="protein sequence ID" value="CDE50870"/>
        <property type="gene ID" value="BN770_00229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="143" mass="16085" checksum="5E0B05CC9F0407F5" modified="2013-07-24" version="1">MKTFMPKAADITRQWYVVDAEGQVFGRVASQVANILRGKNKPIYTPNVDTGDYVIIINADKIVMTGKKLDQKIYYHHTGYVGGLKETKYRKLLAEKPEFAIRRAVVGMLPKGPLGRQMAKKLKVYAGPNHDHAAQKPVKFDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7II64</accession>
    <name>R7II64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative L-ribulose-5-phosphate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000224">
        <property type="protein sequence ID" value="CDE51489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51489">
        <property type="protein sequence ID" value="CDE51489"/>
        <property type="gene ID" value="BN770_00056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="7"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="231" mass="25743" checksum="3078E6A79B5250FD" modified="2013-07-24" version="1">MLKSLKEAVYEANMELPKRHLVTYTWGNVSGISREKGLVVIKPSGVEYDELSPDKLVVLDLDGNIVEGKLNPSSDTKTHLELYKQYPDIGGIVHTHSPYAVGWAQACEDIPCYGTTHADYFYGAIPCARHLTTEEIDEDYEKNTGKVIIEELTKRNINPVHVPGIICASHGPFTWGKDAAQAVYHAVVLEEVAKMAVYTRQIKPDAAPAPQNIQDKHFLRKHGPNAYYGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIH9</accession>
    <name>R7IIH9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">BN770_00435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51435">
        <property type="protein sequence ID" value="CDE51435"/>
        <property type="gene ID" value="BN770_00435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="297" mass="33221" checksum="1755525B44511858" modified="2013-07-24" version="1">MPSAKEIKSRIASIKDTQKITNAMYLISSTKLRKAKNELNRTRPYFDALKGEIKRIFRTVPDVDSRYFYPPAGAPKLEGEYACLVITADKGMAGAYNHNVLKIAREMLHEHPETELFVVGEYGRQHFAQAGVPIEKSFLYPAQNPTLHRAREICDILLERYDNGEFQKLFIVYTDMKNSLSAEATSTRLLPFHRGDFASVAAPGSVHFEFTPGVEAVLDNVIRSYITGFVYSALVDSFCAEQNARMTAMSSAGENADKMLASLSVQYNRVRQASITQEITEVSSGAKAQKRKKVQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIP8</accession>
    <name>R7IIP8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ATP:guanido phosphotransferase CDSM653_1777</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51505">
        <property type="protein sequence ID" value="CDE51505"/>
        <property type="gene ID" value="BN770_00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07930">
        <property type="entry name" value="bacterial_phosphagen_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023660">
        <property type="entry name" value="Arg_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="PTHR11547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="156"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="330" mass="36432" checksum="B7AAAA6079FBFE0D" modified="2013-07-24" version="1">MQSDIVLSSRVRLARNYADLPFDLASEPEQAETCILRTLSALRQAGLAEQYDLLRLRDMSDVSRRAMEESHLVSRDLLRSPETAAVLVKRDSSVSIMMNEDDHLRIQAVRTGDDLLSAAQACFCVDDALSRQNEFAFDQQLGYLTAFPTNAGTGMRASLLLHLPLLTRSKQMGNVGQMVAKVGLNIRGVYGEGAEALGNIYQISNQVTLGRTEQELITTVEAVGQRLTMMEQNLEEKALTTAKIETEDAVQRAFGILTHARILPRGEFYQMYSNLRLGATMGLLPLSVQKVDEVLDQAQDAHLCIYAGETLSGQALDAARADRVRELLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ17</accession>
    <name>R7IJ17_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VTC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51635">
        <property type="protein sequence ID" value="CDE51635"/>
        <property type="gene ID" value="BN770_00537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="1">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="253" mass="29584" checksum="9B63BFA072EE04D7" modified="2013-07-24" version="1">MAGVQCSFERVEKKFVLTHAQAEALMRDLTAGYMAVDQYGQHTIRNLYYDTDDYALIRRSIQRPKYKVKFRLRAYGTPMEDTLIFAELKKKYSGVVYKRRIAVSPDDMRRFLRGETLDGENPQIQRELHRYLSEHPIRPKVFLAYERVALYGLEDPALRVTLDTHLRYRTTRLDCFTDDAGELICPDDPVILEVKLANAAPLWLARLLSRHKIYMSSFSKYGTCYLNHLARRKPDIRPKAHKRNNEGEIEHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ59</accession>
    <name>R7IJ59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coproporphyrinogen dehydrogenase HemZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51521">
        <property type="protein sequence ID" value="CDE51521"/>
        <property type="gene ID" value="BN770_00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023995">
        <property type="entry name" value="HemZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932:SF1">
        <property type="entry name" value="PTHR13932:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00310">
        <property type="entry name" value="oxygen-independent_coproporphy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03994">
        <property type="entry name" value="rSAM_HemZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="161"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="486" mass="54260" checksum="9317883E01FBF822" modified="2013-07-24" version="1">MSNEIQQGLQDDLTTIEPDLMNMTRLFSLPDSVWDAPEYHFAAAIEGGQYVIRFYGKTQAAQGVTDIPSDADARIQALHRRRALRRLCRQTLYDLLRKETGIHPPWGSMTGIRPTHLMYEALNEGMSMADAQKHLVHQFDVAPEKAALLAELVSVQQQLPPPGDDWMDVYIGIPFCTTRCTYCSFSSGELGDGHLVAPYLTALFREMDACAQLLRDAGKKLRAVYVGGGTPTSLNEEQLPRLLEKMMQCFPFAMEYTVEAGRPDTLTLPKLEAIRRAGIQRISINPQTMNDKTLRVIGRAHTAQQVEEAYAMARTAKIHHINMDVIAGLPGENIDDFARTMDAALRLTPESLTVHTLAIKRSSRLHLENAPLPDGETASRMVQLGLDTAHQLGMKPYYLYRQKYMAGNQENVGYALPGHACQYNVDIMEETTHILALGAGGISKRVYPEEGHIGRAPNVSNIEQYIARVEEMIGRKKALFLPEMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ76</accession>
    <name>R7IJ76_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urocanate reductase</fullName>
            <ecNumber evidence="3">1.3.99.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>A + dihydrourocanate = AH2 + urocanate</text>
            <dbReference type="Rhea" id="RHEA:36059"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:27247"/>
            <dbReference type="ChEBI" id="CHEBI:72991"/>
            <dbReference type="EC" id="1.3.99.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.33" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000226">
        <property type="protein sequence ID" value="CDE51536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51536">
        <property type="protein sequence ID" value="CDE51536"/>
        <property type="gene ID" value="BN770_00485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="1 3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022250457" description="Urocanate reductase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="4">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="598" mass="62537" checksum="E14E99EC5F8FDE27" modified="2013-07-24" version="1">MKKFLSLLLALTMLLTLCGAASADAGVFTGVGDSEIGGKGAIEVAVTVDENGAVTAIEVTKNGDTAGISDPAVAQIPGLIVEQQTANVDAVAGATKTSDAIMAAVLDAVTKAGLDTVKWSTKVETVAEKAEDVTIETEIVVIGGGGAGLAAAVQANQLGSKVLVLEKMGKVGGNTILAGGALNAVNDRSEQAIAYNDSVEWHYTQTLSGGDYQGDPLLVHTLVSNAWDGVQWLMDLGMEFQDETAGLFTVTGGLWPRAHKPVEPLGTGFFKAYMNYIDSHDNVDVMLNTRATEILVDENGKACGVVATGETGNTVTVKASKGVVVATGGFAANVELRSAYNTQWADLGDSIKSTNHAGATGDGIKMLQKLGADFVQMGNIQLLPLGDPVTGSLSGNIEHDVETRIFINKEGNRFVNEGGRRDDMTNALFAQTDAYMWIVMDSDTYPTGDERNNFGETANKLVEAGRAVKADTLEELAEKMNVPADALIAAVTEFNRHAEGGDLAGTPDEFGRTLYKTPIDTAPYYAAARVPTVHHTMGGVRINVNAQVLDENGNVIPGLYAAGEVTGGIHGSNRLGGNALTDTVVFGRIAGESAHYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ80</accession>
    <name>R7IJ80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000215">
        <property type="protein sequence ID" value="CDE51353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51353">
        <property type="protein sequence ID" value="CDE51353"/>
        <property type="gene ID" value="BN770_00393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="540"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="921" mass="103886" checksum="36B11C99F40B5B8B" modified="2013-07-24" version="1">MNYIELLTQEEKVNLCGIMGGRDFKELFKHNEREFQKIRKGFRAKSLTEELALSIAIANVDKPFIASWVNARVQIWLDEIQENITKLEGEGSAHDIALATTMLDFFFSHDVDLYLKLAGITMDEVSRTELRTTMERIESDRAKEEKDADRIKALEEEKQRLLCQIEDCHQSASLLKTEYEQMIQEIEQEKKDLESSLAAAQEKISELQTSLTVAKSDESSHLSQYDDTDISSLPPVGSEETISLCNVISDYSGQKWLIRFADLSHNGHYHMFHRNEELPPYFANRDKIFYKDGPSTDGFYGIWSWSAIPNEKDPSKDYIISKYNVNLDAIEIATIPEASSLEELIRLLKDGFVYQPHSRRIMFSLYASKGQYMGILCSIKELNVTNGKVSFAEDCIEVPVYEFNSDNILRLENGLSFYRNAFAGLPNKLYQLKSPLDIVKNIVFSSISWTAYKTRGYTRAEYRSFKDFLGAIPVENIVQRIEAECRCSDSVAKELLNEFLSIVWKYVDGDSLEDDVILSAISASSELQERTKALIRLDWEAEHKDLLTDAQRELDLLNAKLESVNTSLTEAQEAFSKTKLEDERLSNVIAEKEKLAEDVEAAVADRIEMARKNAAGFIANMAFVDRHPNEAAAKQTPKAVETLAQPVASQYHAYSAAKELDDLEVHHSWNEVINTASFELGEAGVADRYRNGLAAFLCAAYIGRQPILLVGPNSIDISKALCAAIAGHKHGMLSCEGSYSSHVLQELGHDGEDIVIINNLFASGWMNRLPEILSKKDIFYVATHPYAEDIQVEPKSLYGFMLPLFTEFFVDNKASGKYYGGYFADDFKPYAAQPASSKELRILPRLSLSTLVKNRINSVISTMHGIHSSTTADEEFIFAILPIAYATLELNDLTEMIADPQKGIELSASLKRDLRFILGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJB0</accession>
    <name>R7IJB0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="9" type="ORF">BN770_00406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51388">
        <property type="protein sequence ID" value="CDE51388"/>
        <property type="gene ID" value="BN770_00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="162" mass="17992" checksum="FEA62BC7F9108E93" modified="2013-07-24" version="1">MRKPVSQRLLPFLLILLTLALDRFTKALAVALPDERTLIPGILRWIYVENTGMAFSLFSGRSWMLGVVSVIAVIAGWLVLRRYQLSGWSRTAAALMIGGALGNAYDRLALGYVVDMLDITLFPFAVFNIADAALVVGTVLMAYCIVFRTEDWRKINHDANDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJB8</accession>
    <name>R7IJB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000217">
        <property type="protein sequence ID" value="CDE51398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51398">
        <property type="protein sequence ID" value="CDE51398"/>
        <property type="gene ID" value="BN770_00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436678" evidence="1">
        <location>
            <begin position="23"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="503" mass="56845" checksum="9CC120B2C0F501F8" modified="2013-07-24" version="1">MKKRWILLILPLMMMVMPVASANGWGLPEALVPLVSNTNDYDDYYHLADDYARKENSARIIMQSRYHNQLIAAEKGADGWKSVIVSTTAVYQPSEQSTSGKPKLTRIKNGFELAYPKVKELYRFEYISNDWGEMAYTLMYAKMGSVEIERKESYRYLVTQGTDSAMWVTEVTLENFNIHNMPRRGVGDVRRMRNVHSSIALYYSYDNVGWIGAQTVPGQKSGKQSYPVYTAPSTEASRAAKGKASFSTGDDYRIYCTEGDWSLIEYRVSQRTSRFGWAQIGQPPQSLRLHIPMLTAYDTYLTDDPHVSEYHQAELPAGTKLTMWYLLGVRDDWAYAYVEATVDGKPMCGFVPRRDVVIDEVELPDEAAKYVGSWYLYSGSEIGYLYLRLDADGRFYCSDTDGAQPYGGTWCVVQNPMAGEDNFWISAESILVLNYSDSMTMRFGVDYIVSTTEEDGEGLTLPLMNLAYGEGGCTYVPYGAVDRYGNWVATADGSVRQMTLPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJC8</accession>
    <name>R7IJC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000239">
        <property type="protein sequence ID" value="CDE51725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51725">
        <property type="protein sequence ID" value="CDE51725"/>
        <property type="gene ID" value="BN770_00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021560">
        <property type="entry name" value="DUF3021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11457">
        <property type="entry name" value="DUF3021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="147" mass="16318" checksum="C4BCF0F8F02BE910" modified="2013-07-24" version="1">MKKQVFLRSLLGAFVGCFIGVVIIICISLAIGGGDMHVATPALLAQVGSEVGAFSLQMAAAMLIGAIWSGASVIWEVERWSLLRQTLTHFLLCSVVCLPIAWAMGWMADQPGWYLFGFVAMYAGIWLINYLQIRRRVREINERLKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJI4</accession>
    <name>R7IJI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma-24 subunit ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000224">
        <property type="protein sequence ID" value="CDE51483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51483">
        <property type="protein sequence ID" value="CDE51483"/>
        <property type="gene ID" value="BN770_00053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="199" mass="22832" checksum="8C71C0740F62203C" modified="2013-07-24" version="1">MDELILRRAQKGDASAFEQLVTPYEQMIWRVCWHYLHHREDAMDCAQEVMLKAWRSIGQYRQDCGFSSWLYRIAGSVCIDFLRKQKRMVDSDSMDAMAENGFEPADDSPTPEAELLDRESTGDISRALDQLPADMRTVVILYALEKQRYEDIAQITGVSVGTVKSRLNRARQKLAAILANQREQNEKSSVLPSERRTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJJ1</accession>
    <name>R7IJJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51651">
        <property type="protein sequence ID" value="CDE51651"/>
        <property type="gene ID" value="BN770_00553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="601" mass="63867" checksum="F62904FE903EF660" modified="2013-07-24" version="1">MLTGLVSIAGAESTASTLPIKVELDFSKYQFTAPEEITVTIRVTNVTDEKFTSPVSVLDPNGSIIEAFGTPLLDAGASQSCTIAWNVTQADLNAGQLAFRVRYPRKDENGIVSNASNNFVKRISQVQAEPEIQVSRTITPGIARKGQEVSVVYEIRNVGTVDVTGVRIKESSAVSSNTASIGAIPAGEKKSHTFTVTMGTKNITSNATVTYSAGGKSYTEKVADAAIKYGTVNLTATLTADRKGGNVGDEVKLTLTLKNTGKKNITGITVTDPTLNTVFTDVTVDAGKTVKLEKTITMTETAEYQFTVTGMEGTTGIETATGRLPLTAIDPAKAPSLTVETTASTDVVFTLPSVIRFTITVTNTGNYDAKKITVSSSGVSLASIAQLAPGESFTTMRDVQVNMVGKFRFDATLSNELGEATTFEGNIIQVQQAAPTSAPTQVPVTTPQPFVAEELPTEDTLPAAVTTFQGVLTTLYYIFAVLAVISAVLLAVSIAGRVMNRPKDGQEQLQLSERRNYTEEVPEDERVMIADESENAPEAEEKPETAETADAVQTADDVAANEKPASAEAQQVFTADDMAEDGDAMEDAKAQIYGRSKRGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJR6</accession>
    <name>R7IJR6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000255">
        <property type="protein sequence ID" value="CDE52024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52024">
        <property type="protein sequence ID" value="CDE52024"/>
        <property type="gene ID" value="BN770_00755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE52024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="421" mass="45672" checksum="771F894075C804CD" modified="2013-07-24" version="1">MSNYKFETLQLHVGQEQPDPATDSRAVPIYQTTSYVFKNSAHAAARFGLADAGNIYGRLTNSTQDVLEKRIAALEGGVAAINYTIQALAQDGGHIVAQKTIYGGSYNLLEHTLPHFGITATFVDAHNLAEVENAIQNNTRAIYLETLGNPNSDIPDIDAIAEIAHRHSLPLVIDNTFGTPYLIRPIEHGADIVVHSATKFIGGHGTTFGGIIVDSGKFDWKASGHYPAIADPNPSYHGVSFADAVGPAAFVTYIRAILLRDTGATISPFNAFLLLQGVETLSLRLERHAENTKKVVAYLAHHPQVEHVNHPSLPEHPDHALYEKYFPNGGASIFTFNIKGGQKEAHKFIDSLKIFSLLANVADVKSLVIHPATTTHSQLTDEELADQGIAQNTIRLSIGTEHIDDIIADLEQAFEAVKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJR7</accession>
    <name>R7IJR7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-rhamnose isomerase</fullName>
            <ecNumber evidence="3">5.3.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rhaA</name>
        <name evidence="5" type="ORF">BN770_00222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-rhamnopyranose = L-rhamnulose</text>
            <dbReference type="Rhea" id="RHEA:23160"/>
            <dbReference type="ChEBI" id="CHEBI:17897"/>
            <dbReference type="ChEBI" id="CHEBI:62346"/>
            <dbReference type="EC" id="5.3.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rhamnose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50827">
        <property type="protein sequence ID" value="CDE50827"/>
        <property type="gene ID" value="BN770_00222"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008740">
        <property type="term" value="F:L-rhamnose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00541">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009308">
        <property type="entry name" value="Rhamnose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06134">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="419" mass="47524" checksum="AE6A0AD8B408A678" modified="2013-07-24" version="1">MSYQEAKQKYAAIGVDTDAAIARLKTVPISLHCWQGDDVRGFDTDPSKPLTGGIQTTGNYPGRARTPEELMADIDVVLSLCPGTKKINLHASYAIFDEENPWVDRDKLEPKHFRKWVDFCKARGLGADFNPTYFSHPMCDPLTLSSPNEETRRFWINHGKACIRISQYLAEELGQPCTMNIWTGDGFKDVPADRKGPRDRYRASIDEILSEPYDFHLVKPCIESKVFGIGVEAYTVGSAEFALTYAAYNRDKCIPLMDNGHYHPTEVVSDKIPALLAFFPEIALHVTRPIRWDSDHVVLLDDETKEICKEIVRCGGLDGRVNIALDYFDASINRISAWTVGFRNVQKALLSALLTPNDALRALQDEQRFTELMVRQEALKTMPFGDVWDEYCRSCNVPVGMDWFETVQKYEHDVLSKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJS7</accession>
    <name>R7IJS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase beta-lactamase superfamily III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000239">
        <property type="protein sequence ID" value="CDE51716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51716">
        <property type="protein sequence ID" value="CDE51716"/>
        <property type="gene ID" value="BN770_00581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="272" mass="29318" checksum="5C777285384F832F" modified="2013-07-24" version="1">MELTVLGMNGPFPAANGATSGYLMRGEKTRVAMDMGSGTLGRLTALMPPEKLDALLLSHWHFDHCSDVLPLLFRLQACAAKPLDVYAPVDESSMVRKVVQQSGAFCLHDVQKDDKVQIGEFSVRVFAARHPVPGVMYRVTDGEKTLCYTGDTNTVEGLTDFAQDADLLLADGLFPTAMWQEGLPQLSPAPTAXXXPATSVRGADGGTGARCSREEARYHPPEPEHRPGNAAQTGAGDSRGRGAGAYRRNVSCLTREHGTHCCKPLFCPARRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJZ9</accession>
    <name>R7IJZ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000244">
        <property type="protein sequence ID" value="CDE51766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51766">
        <property type="protein sequence ID" value="CDE51766"/>
        <property type="gene ID" value="BN770_00604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="46"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="204" mass="22376" checksum="8808FC8B857A8B1D" modified="2013-07-24" version="1">MARGVKRLLKILLVLILLGAIAYVSIVLMVCWKETHVAAPGKDYEAMLVLGAQVKPDGAPSLQLQWRLEKAAETYRQKKVPVVVCGGQGGNEPAPEAIVMRDVLVGLGVDEDMILMDTTSASTHSNIKNAMQLLGGRNVTKVMIITSDYHLPRAIAIAEDNGLTAYGIGAPTKLGLRFWLKNHCREALAWCKYWAVKYTHLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK93</accession>
    <name>R7IK93_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport systems permease components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51886">
        <property type="protein sequence ID" value="CDE51886"/>
        <property type="gene ID" value="BN770_00671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="326" mass="36762" checksum="291F80D148652490" modified="2013-07-24" version="1">MSKNGMTRYIIKRVLYMFLVLFIIMTMCFILIKLLPLPAVREMGRDINLVLAKREKMGYNKPIMVQYFLYLKSILTEWDWGVGEQMYEGMGVWAVMMQKLPYTVLVNLYSILIAIPLGLAFGIYAALKKNKWQDNFISTMVMVFISVPSYVYAFLVQYFLCFKLGWFPLQAASLSQAGGSLFSWTMFVSLIPAVLSLGFGVVAGLTRYTRAELSEVLTGDYMLLARTKGLTKAQAISRHALRNAMVVILPMIIGEFIGILGGSMIIENIFGIPGIGNLYINSINVRDYNFFMALNVFYTAIGLVSGIVIDISYGFIDPRIRMGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKC9</accession>
    <name>R7IKC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51936">
        <property type="protein sequence ID" value="CDE51936"/>
        <property type="gene ID" value="BN770_00703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="116" mass="13051" checksum="C1B176A63897C47B" modified="2013-07-24" version="1">MQMFVLVLNREEFLEPLLEEMLKQNIGGATILESTGMMRVLDGDHNIDDLPVLGVLRHLCNPERKRSKTIFTLLKSEQIPQMIEIINKVTGGLDKPDTGICFALPTTFVEGVNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILX8</accession>
    <name>R7ILX8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51637">
        <property type="protein sequence ID" value="CDE51637"/>
        <property type="gene ID" value="BN770_00539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025584">
        <property type="entry name" value="Cthe_2159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14262">
        <property type="entry name" value="Cthe_2159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436039" evidence="2">
        <location>
            <begin position="23"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="625" mass="62217" checksum="659B93625E0F9454" modified="2013-07-24" version="1">MKKWLITMMAVATLLLAGSALADENITLSPDGSTSTDASVLIDGQTVTITQAGTYQIAGTLGDGALIVESTENAKITLVLGGVSIKNTTGAAIQIATADDVTIELAEGTTNVLQSGEEVDIAAATEGEEASGGALQSKVDLKIKGKGSLTVLGYLNNGIHCTKDLKIKNGNISVTALGHGIKGKNSVTVSGGTVTVTSGKDGITSDETENEEKGFVTIEDGEIIITSAGDGVSAETTLTVTGGVVSIISGGGSANAQQKTDNMRGWWDFDNSASDDNSASCKGLKAGKALVISGGSITIDAQDDALHTDGDMTISGGECILSTGDDGAHAALSLTVLDGKITVLTSYEGLEANQITLAGGELDITASDDGINANGGSDGFSGGFGGGFGGGRGGMGGSFGGRRNDTNNQSGDMTPPDNNNMTPPDNSNMQNPPDGNAPSGNPPTMPGQDAADSTTTDDTTDKQPVLLITGGKITVNADGDGLDSNGNLRVEGGDITVNGPSNGGNGALDIGTENGGAGVIAGGTLIALGTSSMAENFGSTSTQCAFLVTMNSFGAGETITITDSQGNVLYTGVTVKSANSVVFSSADLVVGETYTVTIGSTSATVTQSSTVVGNSNGFGGGFGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMT0</accession>
    <name>R7IMT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-associated-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51937">
        <property type="protein sequence ID" value="CDE51937"/>
        <property type="gene ID" value="BN770_00704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="25546" checksum="6C8B14DC47B7B2E0" modified="2013-07-24" version="1">MASYTIEDIELIRRKSGISYQEAVSLLDYHNGNVARALVDLERNGRLKPDAAAQDAPKSAEKKATTAAASKSKGGFMHFINKLYRARVKVARQSIPILNISLLFTLVAALISPHLLILSAILILLLGYRVSFDKDDADFAGENMDRMVKNAASNVRSTVDEFARGFQAGMNGQSESSEKKAEVDSADNRSYYAASAAKPEYHSCPTINVPVQVPSQDGNVTVEDDTDGFNSATIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I2Q4</accession>
    <name>R7I2Q4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46184">
        <property type="protein sequence ID" value="CDE46184"/>
        <property type="gene ID" value="BN770_00765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="451" mass="48930" checksum="A5ADED562E4FECD9" modified="2013-07-24" version="1">MKDLTVGKPGRVLLAYSLPLFGSIIFQQLYNIADSFVAGHFISTEALAAVGNSSEITLIFIAIAFGCNIGTSVVTANLFGQKEMKQVHTCVTTALIFCGILGVLLSAVGILTSEWMLTLLDTPVETMKDSVAYIQIYLMSYVFLMLYQVATGIFSALGDSKTPFYFLAVSSITNIFVDILFVRDFHMGVPGVAWATFLCQSISGIVAVIFVLKKVHEVVGGEKCPLFSGVLLKKMLIIAIPSAIQQSFISVGNILVQRVINGFGTACMGGYTAAIKLNNMFVTSVTALGNGMSNYTSQNLGAGKNERVRHGCRSGVTIGMTMGAIFAVVFYVFAKPLVYAFISDGNLEAVDVGVDFLHIVTPFYVFLSIKLMVDGVQRGAARMLQFMIATLSDLFLRVVLSFTLSPIFGIRGVWYSWPVGWVVGIVLSATLYLVWARKLTAREEKTPVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I398</accession>
    <name>R7I398_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside recognition domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46359">
        <property type="protein sequence ID" value="CDE46359"/>
        <property type="gene ID" value="BN770_00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="168" mass="17508" checksum="9551D08EB8327534" modified="2013-07-24" version="1">MEKAAAVTLILTVLLILLRGKCAGVEVYGAFLSGAKKGMDAAWQLLPALTGMLLMLSLMNASGLTALLVRLLSPLTAILNLPQEVAPMLILRPMTGSGSLAALQEIFAQYGADSRVGRIASVLMGSSETIFYTMSVYLGAAGVKKLPGALGVSLLSYLTCAWVCGLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3U6</accession>
    <name>R7I3U6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46574">
        <property type="protein sequence ID" value="CDE46574"/>
        <property type="gene ID" value="BN770_00941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="113" mass="12586" checksum="1BD70AAB1C49E094" modified="2013-07-24" version="1">MILDLQHISETPIHNFKGGDGMVYTRMYSDDLNRIMLARITPGSSIGMHTHETNSEIVYVLSGTARIMMDDGEEIVHAGQTHYCPKGHRHATYCEGDEDLVIYAVVPEHGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3W0</accession>
    <name>R7I3W0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PglZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000003">
        <property type="protein sequence ID" value="CDE46166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46166">
        <property type="protein sequence ID" value="CDE46166"/>
        <property type="gene ID" value="BN770_00762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PglZ" evidence="1">
        <location>
            <begin position="235"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="487" mass="55566" checksum="A9DEEBA7DFE9CC8C" modified="2013-07-24" version="1">MFGEYVYGNSPATYANLIWINDADRLNRIAPYSSAFAEHGFEVVEYQDDLSFRIGYEKKVKSGNEKLAVMSYDKEYIPYDILTRFTAYAVSLRALFPKLNLDVLRHKSKMDLDLLTMVIAKNFDDLTTPEQTEKFFETVVYSKDNLLRYFRSKLEHTLQKAKSSPSYRDWYRVAEEKAHIDRYSIQYGLNIDTSVINRLFQGYVLKSFGTLSSKIDRDTPVLVSRAMEYMHGQSEKFAIIVMDGMSEFDWSIISQYFVDVQYKQEAAFAMIPSTTSISRQCLLSNKFPSQLIAPWVQREEKAEFTECAKSLGYADSQIDYSRGYDTDFGNSVRCGAVIINDIDDMVHAQPQGRLGMYNDISVLSDEGKLWKLTERLLAKGFDVYITADHGNTLCNGIGRFVGAGVDVETKSHRMVVLKDFADKAKLADKFGLIEYPKYYLPKEYDYLICDTDTSLDNSGDQVMTHGGMTIDEVVVPFIKIKAVQSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I481</accession>
    <name>R7I481_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46455">
        <property type="protein sequence ID" value="CDE46455"/>
        <property type="gene ID" value="BN770_00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="265" mass="28913" checksum="0214F296184631B9" modified="2013-07-24" version="1">MKQYGLIGEKLGHSLSVPIHEAIWEKISLEASYRLIEIPRGELAAVVPELLRTLDGFNITVPYKTDVMPLLDEITPFAREVGAVNTVLTGKTSRGYNTDDPGFEQMLRHFGMNPDGRPVFILGSGGAMHACRNAVERMGARETWVVSRNPKHADEISYDDFYTRFPDMGGLIVNTTPAGMYPRVEGCPIDAAHLTSIVARADGVADIIFNPAETVLTAAAKRAGTPACTGLYMLIAQAVEAESIWQGCSMPPNLAETLMKELHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I490</accession>
    <name>R7I490_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsf</name>
        <name evidence="10" type="ORF">BN770_00999</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46699">
        <property type="protein sequence ID" value="CDE46699"/>
        <property type="gene ID" value="BN770_00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="73"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE46699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="309" mass="33746" checksum="FB1DEBEB79C442EB" modified="2013-07-24" version="1">MANITAALVKELRERTNAGMMDCKKALVESDGDMDKAIDWLREKGLAQAAKKAGRIAAEGAVVAYMTPCGCTGALVEVNCETDFVANTDNFKNFANAVAKHVALANPADLDELMKQKFVDDESKTIEDMVSDATVAIGEKITVRRFARYETEGVVSSYIHMGGKVGVMVEVATDEVGKNSDLVKEFAHDVCLQIAAAKPEAVRREEVDADKLAKEAEIQRAKAIESGKPEKIVDRIVAGQIEKYYKEVCLLDQQFVKDGDKTITSLMNETAKAAGTTLDIVRYVRFERGEGIEKRKDDLAAEIAAMKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4M7</accession>
    <name>R7I4M7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-threonine aldolase low</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000016">
        <property type="protein sequence ID" value="CDE46436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46436">
        <property type="protein sequence ID" value="CDE46436"/>
        <property type="gene ID" value="BN770_00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="341" mass="37267" checksum="D83D444B27FCD0E1" modified="2013-07-24" version="1">MIRLNNDYSEGCHPSILLRLNEMNLEQNPGYGTDTHCAEAADAVRKAFACPDADVHFLVGGTQANMTVIAAALRPYEAVLCADTGHINVHETGAVEGTGHKCIALQSRDGRISASQISVAAAMLDDNEHVAKPAMVYISMSTELGTVYNRAQLRDIYLTCQQLGLYLFIDGARLGYALAAPTGDLTAADIAEMCDVFTVGGTKMGALFGEAIVINHPALKKHFRHMMKRQGGLLAKGWLLGVQFSALMADGLYFQLGQKAVKQAMRIRTALLEKGIPLHVDSPTNQLFPIFSDEQVEALEEDFALEFQERVDESHVVLRVCTSWATPERNVTAFIEKINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4P9</accession>
    <name>R7I4P9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46461">
        <property type="protein sequence ID" value="CDE46461"/>
        <property type="gene ID" value="BN770_00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="291" mass="31524" checksum="D2E9ACCC860389E5" modified="2013-07-24" version="1">MNTVYWVLVAFGIVVLEARLRARNVRYLPILPAIVLGAVLSKVSYVVLQWHYAFPRWSWGAFTVFQPDTFCFFGGAVGVVLGVIISAKLTHQKVLPVLDAFAPAGALLVAIARFGEKYLGEIGTAGFEMPEQLAFFPFALTNEWGESYPAIFMLSCLAALIVAIVGLTRKPGGRDGQLFLRTAFYLALPQIMCESLLAECMKWGFVRVQQLLCALTLLVILLAECRRAAGSLSFAKRWWPVGALLLCAAGLVGVEFALDKSGLPAFVGYGAMVVLLALIAAAECGAAKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5G8</accession>
    <name>R7I5G8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000028">
        <property type="protein sequence ID" value="CDE46885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46885">
        <property type="protein sequence ID" value="CDE46885"/>
        <property type="gene ID" value="BN770_01069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="145" mass="16279" checksum="3298F17F5F0369AC" modified="2013-07-24" version="1">MPELKRRRRAASEPDADSADATQEYSPYVPTFQSACPEDPNAQPTFTNESTWQPDYADDDADIPAPTAEEVFADEALEDPDLYLTEEEQAELRQNHWRLLSGFGDFISIIAGCAVILVLITMLVSLLNWLHSDILQSISLFQTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5N2</accession>
    <name>R7I5N2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000025">
        <property type="protein sequence ID" value="CDE46781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46781">
        <property type="protein sequence ID" value="CDE46781"/>
        <property type="gene ID" value="BN770_01015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="43" mass="4805" checksum="0612F82583BA3063" modified="2013-07-24" version="1">MATTKKDKKQKSDRRQLAISITCIVIVAAMLLTSLITLLPIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6B0</accession>
    <name>R7I6B0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46753">
        <property type="protein sequence ID" value="CDE46753"/>
        <property type="gene ID" value="BN770_00067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="295" mass="33424" checksum="5C9AE2871B8314D5" modified="2013-07-24" version="1">MARKKKIHHRHNRLSFGGKLAFVLLTILSAVILIPIVFTFLYSFFPQSEITAYLKGRGSYDTTKWLDVLYSPAMFSLRQYYKIFIEEPSYLKLFCNSMMYTGAILVGQALIVPLTAYCLSRFQFHGRDLLFFCILVLMILPFQVTMAPSVTVLRWLGIMETPWAVILPMCFSPFYIFLLRQFMVGIPNELLEAGMVDGVGPVRGFVHVILPVCKPILGAAAALSFADCWNMVEQPLIYLANHTNLQPLSVMFNQISTDRADVAFAGSALYILPTLLIYLYFQEDIVAGIQLSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6F8</accession>
    <name>R7I6F8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ribokinase</fullName>
            <shortName evidence="6">RK</shortName>
            <ecNumber evidence="2 6">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbsK</name>
        <name evidence="8" type="ORF">BN770_01251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 6"/>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47449">
        <property type="protein sequence ID" value="CDE47449"/>
        <property type="gene ID" value="BN770_01251"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="7">
        <location>
            <begin position="3"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="211"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="296" mass="31482" checksum="2A5CAA72A909757D" modified="2013-07-24" version="1">MKILNFGSLNLDNVYQVPHFLQAGETMAALSEAVHPGGKGLNQSLALARAGADVYHAGVVGNGSELLTNLLKENGVHDDYLLHCDCTQGSTMIQVSPKGENCILLFGQSNHAITKAQVEETIAAFTPGDYLVLQNEVSCLPEMVEAGARRGLHVVLNPSPFDDSLRSLDYNQICWIFINEVEGHQMTGETAPDAILSALRAKYPALCVVLTLGSAGSICCTPEKTVHQPIFRVQAVDTTAAGDTFTGYFLAALTQGLPLETCMARAAAASAISVTRQGAAPSIPRAEEVDAMLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6S7</accession>
    <name>R7I6S7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47335">
        <property type="protein sequence ID" value="CDE47335"/>
        <property type="gene ID" value="BN770_01213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="45" mass="5014" checksum="99FC599AD0B1395D" modified="2013-07-24" version="1">MPATNTATPTETKQTAEQIPQPKEPTKGFDPDSIRAFLKKLTQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6X4</accession>
    <name>R7I6X4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47395">
        <property type="protein sequence ID" value="CDE47395"/>
        <property type="gene ID" value="BN770_01240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="153" mass="17208" checksum="05DE4C410EBF50A4" modified="2013-07-24" version="1">MADIGKTVKEIWEQSMKAVNKAATNIATSTKQKVDEMNIVTRRKELQNQLGLRLYELWQAGEDVPETLKATLEEMRDLEVKLQELRESKTNAPEDEKSAETPDSAAHAPDTTDVKVPLEDDDVPTIEMPDIPEKPERPMEAPSIHTDDETPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Y1</accession>
    <name>R7I6Y1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion-translocating oxidoreductase complex subunit B</fullName>
            <ecNumber evidence="5">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rnf electron transport complex subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnfB</name>
        <name evidence="8" type="ORF">BN770_01123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 3 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47033">
        <property type="protein sequence ID" value="CDE47033"/>
        <property type="gene ID" value="BN770_01123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00463">
        <property type="entry name" value="RsxB_RnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010207">
        <property type="entry name" value="Elect_transpt_cplx_RnfB/RsxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01944">
        <property type="entry name" value="rnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S" evidence="7">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrophobic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="275" mass="28457" checksum="A04DAEBCB4E18AD7" modified="2013-07-24" version="1">MTVVNILIAAVALGLMGLLFGLLLMGTEKVFAIPADEKRDAVRAALPGANCGACGYPGCDGCADAIACGKAPVNACPVGGKPVADKISAIMGNAEAADAVRKVASVICQGDSEHCKEKFEYRGIQDCVAASVVNDGNKACKFACLGLGTCVRVCPFDAIHVDPVKKIAVVDDGKCVACGKCVAICPKGVLSLRPVTEDVTVRCRNTEPAKKVLSACSTGCIHCGKCFRSCPHGAITMTNGLPVIDQSKCQHCMACADACPTKAMWANFDKRKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7V3</accession>
    <name>R7I7V3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD-GYP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47581">
        <property type="protein sequence ID" value="CDE47581"/>
        <property type="gene ID" value="BN770_01294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="399"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="635" mass="73634" checksum="22B06BD644A8C94C" modified="2013-07-24" version="1">MNSEQIRNFFADYQVVLKRVEQLEAAMCIKSDWDTWCAALRERAEFFRTEYAHMNAIMRSVMPEFAKEEPALDDDAWNQLQISMMDFYRADTHDLALLMELAKILQKHYGHSNNLAAMTDVDLTLAYTNLEFSRILREPYGTRARDYYRKISVLSRNFGAIKEHSVHQAIVISYANLVMSCCVLGSVTMQEAFSMWEEMKELQASDALAATRESEPDVGRLLDIFTERFRTDAYALAKSFDRTIEAHTRYVPPELMSRIEQITAEYYEKLDKPEESTADMFQIITSQCDFDCETGRRTADECWKEIHTFFRKTKPKVEQLGEVDVREIDVISYYMTCLDALISFLVETTMPMEDKKRYFREYQQDIRNFIADYDTRTGHSNTLNNALEELAFFPNAYALFDTAEEKIDYIFRLVVARHCTAFLHSLMVSAFAEAILSAIIDKEPALMVGYHGVTSPEDVQAHRVEILQFAHDAALLHDVGKNSMLEIIETQHRPLTDEEFGIIRSHPNRGGQYLSIDEDLARYVDIARGHHKFYNGKGGYPNDFDNTASPERFMIDIITVCDCLDAATDQYGRNYHQAKTTDEVLAEFKRDAGVRYNPDIVRFILQDSALRDTLREISGSRRLTIYYDTYKHYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I823</accession>
    <name>R7I823_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000056">
        <property type="protein sequence ID" value="CDE47656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47656">
        <property type="protein sequence ID" value="CDE47656"/>
        <property type="gene ID" value="BN770_01324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="115" mass="12990" checksum="2F03483206C1F724" modified="2013-07-24" version="1">MTGRFERVVTEEDCETGAYADDGQTVTFPLAADFSAMMLGSMTDADMQLVPVTDLRAWYISAYLDDTAPESGEIVFQHDASQESETFDFWFITVQIRLNDAGEIAYMEYVYVPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I846</accession>
    <name>R7I846_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47750">
        <property type="protein sequence ID" value="CDE47750"/>
        <property type="gene ID" value="BN770_01337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="66" mass="7614" checksum="A074E34422823110" modified="2013-07-24" version="1">MEENKKQPQSTSEQQTESSDPKAPRRGRNWITDMYDKVNLSVDTLNYIALGLLIFIFAVIFIASRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8E0</accession>
    <name>R7I8E0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000081">
        <property type="protein sequence ID" value="CDE48149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48149">
        <property type="protein sequence ID" value="CDE48149"/>
        <property type="gene ID" value="BN770_01561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="212" mass="22598" checksum="5E8F812FA6439481" modified="2013-07-24" version="1">MSQTTSQTCAYEYTVRRGDSFYLIAHRLGVPLKDLLEANSDINPARLMVGDVLCIPGAAAETPDTNITAPTTPDVSDTTTNDALDTPAADMNAPATPGGETPDISFCPEIDRYTVLQGETAADVQLKKDVNRHTLETANPDVNLDALQAGQVLCVPENQACTPGNTYTLEKDETMETTALLLNVSLSALLRANPCLAPSDFKQGACINIPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8G9</accession>
    <name>R7I8G9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase</fullName>
            <ecNumber evidence="5">5.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5-keto-4-deoxyuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">DKI isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kduI</name>
        <name evidence="6" type="ORF">BN770_01421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate</text>
            <dbReference type="Rhea" id="RHEA:23896"/>
            <dbReference type="ChEBI" id="CHEBI:17117"/>
            <dbReference type="ChEBI" id="CHEBI:29071"/>
            <dbReference type="EC" id="5.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the KduI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47905">
        <property type="protein sequence ID" value="CDE47905"/>
        <property type="gene ID" value="BN770_01421"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008697">
        <property type="term" value="F:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00687">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007045">
        <property type="entry name" value="KduI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027449">
        <property type="entry name" value="KduI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38461">
        <property type="entry name" value="PTHR38461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006625">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="276" mass="31237" checksum="212AAA04F0795360" modified="2013-07-24" version="1">MELRTASSPRDVKTYDTQRLREEFLIDDLFRADDIKLVYSHIDRIITGSAVPVKGTLALTAGEELRAQYFLERRELGVINIGGEGTVTVDGTVYTLRHRDGLYVGRGSKDIVFASKDAANPAKFYLNSCPAHTAYPTVYIRPEDCVRQELGSLETANHRTICKYILPGQVQSCQLVMGMTKLEPGSVWNTMPCHTHDRRMEVYLYFDMPEDAFVMHFMGEGQETRHIIMRNEQAVISPSWSIHSGCGTQAYTFIWGMCGENQDFDDMDGIAMKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8J6</accession>
    <name>R7I8J6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47806">
        <property type="protein sequence ID" value="CDE47806"/>
        <property type="gene ID" value="BN770_01367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="94" mass="10684" checksum="4839DE05B34F4FAA" modified="2013-07-24" version="1">MQHCILVKWTPDAGDKDALAKEAEAIFAQAVADGVATALTIRRNVINRPNRYDLLIELTMTPDMLPAYDASEPHHRWKETFGARIQQKAIFDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8R4</accession>
    <name>R7I8R4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000070">
        <property type="protein sequence ID" value="CDE47886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47886">
        <property type="protein sequence ID" value="CDE47886"/>
        <property type="gene ID" value="BN770_01414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436267" evidence="2">
        <location>
            <begin position="22"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="468" mass="51101" checksum="8F6E1F612E98CC24" modified="2013-07-24" version="1">MKKQLISLILAAILLLSCALAEESQNEEYLLPYIDLYAVSLGENAIFEIPNEWGYQTSDAADVPPMTSLLTDQNQMVMAMKLPADWEATDASDALGIQSFMVEGTALMLGLTTPQSTRLQEMTINDMPAVLVSMNGQGFDILWIGDSGDLYFFLFPNDDDALVQQMIAVAQSLCVFHRKGEQVNPASDFAYTADGGEVTITDYIGTSEHVLIPDTIDGLPVTALADKAFYEKHVTTVVVPDSVTEIGDLCFSGDNYLVSLTLPDELAELSYAALESCFRLMDFDLPQGLKKISGSALQYNYYLTHLTLPSSLTEIEQLNFIGLYGLQSLTLAEDNAAFKLDETNGLLMTADGTRLLHCFSDIVPAEEIILPEGVKIVDPFAFHYDYDVKRIVLPEGVETIGAMAFAMCPNLTEIVIPASVTDIGVMDGLEGRTGIISYKRNVIVTPEGCPAWNWAVETGATVKSPEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8R6</accession>
    <name>R7I8R6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48244">
        <property type="protein sequence ID" value="CDE48244"/>
        <property type="gene ID" value="BN770_01594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="129" mass="15138" checksum="52CDDD9BE574728F" modified="2013-07-24" version="1">MNLQYRMILDYTARVERLHLGKHPMKLTVDVANYIQHHMSEPITAEKIAEELFLSRPYLSRKFKEETGESQMDFILKEKTEEAKRLLRYSDKSLTAIGSYLGFSSASHFSRVFKTYVGSTPSEYREKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8U5</accession>
    <name>R7I8U5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48274">
        <property type="protein sequence ID" value="CDE48274"/>
        <property type="gene ID" value="BN770_01613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="182" mass="20822" checksum="92FAE3CE214FCC73" modified="2013-07-24" version="1">MNNTDMLFVQKKLNDLVGCTLINLSRTADLLCLSFAPRALTTEVQEEQSLHLQCYYRLVQDGRVSLARSDYFQPSEAMWDLWRKQGLEEDVIPDDYRCDELGANRLDDRIVELNDVLTGIENRFIVRTVMVDSIGDVTLCFDNGAVWSILVDTSGGEECWRYLPANEEQPQLVLYSDGIECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Z9</accession>
    <name>R7I8Z9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_01098</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000030">
        <property type="protein sequence ID" value="CDE46997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46997">
        <property type="protein sequence ID" value="CDE46997"/>
        <property type="gene ID" value="BN770_01098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="6"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE46997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34876" checksum="EABF117C52DB5A5C" modified="2013-07-24" version="1">MTSIRLAPMAGITDWPFRVLCFEQGCDVATTEMVSAMGYLYAPRNHPATVSLIERRDSEGKLLVQIFGKEADLMARAAEELSAMGRFDGVDVNMGCPAHKVAASGEGSGLMRTPENAEKILRAVCKASHLPVSVKMRLGWDDEHINVVDMAKMAEDCGACEIAVHGRTRMQQYSGHADWTYVRKVKEAVHVPVIGNGDIFTADDAARHLEESGVDGLLIGRGALGNPWLFRQVKQRLSGENVTAPTVQERVETALRHYDMLLQWKPERVAVNEMRKHVGWYVSGMRGAAQLRASINLVEDPNEAKDMLRAFAESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I920</accession>
    <name>R7I920_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose/methyl galactoside import ATP-binding protein MglA</fullName>
            <ecNumber evidence="4">7.5.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:60156"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.11" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47748">
        <property type="protein sequence ID" value="CDE47748"/>
        <property type="gene ID" value="BN770_01335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043211">
        <property type="term" value="F:ABC-type carbohydrate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015862">
        <property type="entry name" value="ABC_transpr_MglA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF7">
        <property type="entry name" value="PTHR43790:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="272"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="548" mass="60971" checksum="79B96CA362310503" modified="2013-07-24" version="1">MQKDDVLLRMEGICKSFPGVKALDDAQLTVRPGTVHALMGENGAGKSTLMKCLFGIYSKDAGTIWFDGKEVNFKSSRDALDNGVAMVHQELNQALKRSVMDNIWLGRYPRIKLGGAKMPFVSDKAEYDMTMEVFKDLNFEKFGININPRTIMSTMPVSRRQMVEIAKAVSFNSKIIVLDEPTSSLTEAEVEVLFSIINMLKARGVGIVYISHKMKEIWRIADDVTVMRDGRWITTRHKTEYGTDDDSFRAEVIRNMCGRELSAAYPPKDNIVHDDPMIVVEGLTAKYNQLRDASFTLHKGEILGVAGLDGSGRTELLETLFGYRTRQSGTIKKFNFGFRAAQGGTPEDYSMEVHDINGTQVGEEISNLSPNSAIKQGFALVTEERRATGIFGILDIRANTVIANLKNYKLGKFPLLSDAKMARDTDRMIEAMHIKTPSQRQQIKNLSGGNQQKVIFGRWMLTNPDVLLLDDPTRGIDVGAKYEIYELIQSLAKQGKSIIMVSSEMPELLGTCNRILVMSAGQIAGEYVPTGDGKVDQEKILELAAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I922</accession>
    <name>R7I922_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000101">
        <property type="protein sequence ID" value="CDE48374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48374">
        <property type="protein sequence ID" value="CDE48374"/>
        <property type="gene ID" value="BN770_00134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="153" mass="17858" checksum="98E104C556B2306E" modified="2013-07-24" version="1">MKRFRKFLNDLREPLGIGMKRLMIALTIILGIAIVTVAGWLLWSRIGMAYARNKVSDTYLQNQPAYQSFVADRDDYAYRVRYTTFYTPSDALTEMGVEKIYEEVGSCICFEQAWRALGGIPQGILYAPDTEEVPSWYHRVQLDNDWYYYWIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I983</accession>
    <name>R7I983_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000108">
        <property type="protein sequence ID" value="CDE48439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48439">
        <property type="protein sequence ID" value="CDE48439"/>
        <property type="gene ID" value="BN770_01702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436295" evidence="6">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="69"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="266" mass="29579" checksum="7396A1A2C829EAF4" modified="2013-07-24" version="1">MKHVRRICAVLLAAVVLLPLVLLCVQAFVPPFDALMISTGSEPLRLLPVPFSAEQWQMLSAQSAYWQAFWNSLIWTVGACVVQVIVAFLGGYVLAKYPARWCVAIAGLYTLMMLMPPQMTLLPIYRVAYANKMLNHPMLLYAPIAFAPFGTFFMRQWLLRWPDELTEYLRLEGGSSVKLLWYCLAPYALPGMLALFALTFTEGWNQVEQPLMLVSDSLRQPLSALLKDLSAGNPQIVFAASVASILPIALVMLAVLVQQGSKRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9G0</accession>
    <name>R7I9G0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">BN770_01431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47918">
        <property type="protein sequence ID" value="CDE47918"/>
        <property type="gene ID" value="BN770_01431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="26"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="370"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE47918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="560" mass="62298" checksum="DAEFDE4E38B43FB9" modified="2013-07-24" version="1">MTPRTKAAQPASRLRIVSLGGVDEIGKNMTVFEYEDDIVVVDCGSIFPKEDMLGVDLVIPDVSYLVEKKRNVRGYLFTHGHEDHIGATPYILRQVPAPLYGTKLTLALVDLKLKEHRIQGIPMQVVQPRDEVRLGKNFTAKFIHVSHSIAGACAIALTCPAGTVVVTGDFKIDYTPVDGHITDLASFAELGERGVLAMLCESTNVERPGHTISEKKIGVTFENMFRDAQGRVIVAMFASNIHRMQMVIDNALRYGRRVCFIGRSMVNVSRVAMQIGELRIPPEAIIEADALDQYPDNEILVMTTGSQGEPMAGLTRMAYSEHRKLQIRQSDTVIISATPIPGNEKSISRVIDQLYRCGANVIYKALAEVHVSGHACQEELKLMHALVKPKYFIPVHGEYRMLWQHAVLAESMGMNSTDIVLPETGQVIEMNQEGLYLAEQIPTGAVLVDGLGIGDVGNVVLRDRKHLSQDGLIIVVMAINRDDQRLVSGPDIISRGFIYVRENEDIIENTRDVVRQILAQSSLAGEDWPALKNRIKDELHRFIFEKIKRNPMILPIILDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9M8</accession>
    <name>R7I9M8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48594">
        <property type="protein sequence ID" value="CDE48594"/>
        <property type="gene ID" value="BN770_01737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="25655" checksum="4D22C5E16B0FB692" modified="2013-07-24" version="1">MRRIALISGGSSGIGEACVRLFAKDGWAVVFLCRTHPERAQAITDELRGKGLDVAFRTCDIADSEQVNDTVAAILKDYKHIDALVNCAGIAYRGLLTDMPDATWHHLLATDLNSVFYLQRAVLPGMISRGHGAIVNVSSMWGEVGASCEAAYSAAKAGVIGLTKATAKEVGPSGIRVNCVTPGVIRTPMNAELSDDDLAALADETPLGRIGEPEECAEAILFLASEKASFITGQVLGVSGGLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9P2</accession>
    <name>R7I9P2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylosuccinate synthetase</fullName>
            <shortName evidence="2">AMPSase</shortName>
            <shortName evidence="2">AdSS</shortName>
            <ecNumber evidence="2">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purA</name>
        <name evidence="3" type="ORF">BN770_01628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000094">
        <property type="protein sequence ID" value="CDE48300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48300">
        <property type="protein sequence ID" value="CDE48300"/>
        <property type="gene ID" value="BN770_01628"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="177" mass="19222" checksum="2DAFDFD7E90AF02C" modified="2013-07-24" version="1">MGAGVSPRDMTDIVCVTKAYSSCVGAGAFVSKLDGAAGDELRRRGGDAGEFGATTGRARDVGWFDAVATRYGVMVQGATQVVLTNLDVLGYLDEIPVCVAYEVDGKQITEFPATPTLMRCKPVYVKLPGWKCDIRGVKSYDELPENCRKYVEFIENACGVPIKMVSNGPKRHEVLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA67</accession>
    <name>R7IA67_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000101">
        <property type="protein sequence ID" value="CDE48376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48376">
        <property type="protein sequence ID" value="CDE48376"/>
        <property type="gene ID" value="BN770_00136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="172" mass="20570" checksum="8575F182F4861863" modified="2013-07-24" version="1">MNKLWNLQNYSAEALHRTVRRDGLRVRIHPQVHPFLRREVHTFVRWLRANYPFPIRVNVYIPNTKKIRANDGDLCYGRCFVPDDPDDSITIDVAGGYDYDGDFRALQNYTWGTIFMLAHELGHYYQYLNRVSLTPRGIEWQATYYAHRVQEAYYDAEWDEMDEWAEERADES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAA4</accession>
    <name>R7IAA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved carboxylase region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000089">
        <property type="protein sequence ID" value="CDE48218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48218">
        <property type="protein sequence ID" value="CDE48218"/>
        <property type="gene ID" value="BN770_01584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="466" mass="52401" checksum="4835001FCC4B64E8" modified="2013-07-24" version="1">MAKVQITDTILRDGHQSQAATRMRTDEMLPACEMLDKVGYYSLECWGGATYDACLRFLNEDPWERLRKLRKALPNTKLQMLLRGQNLLGYRPYADDVVDFFVKKAVENGIDIIRCFDALNDLRNMQTAVKATKKYGGTAEIAMSYTESPVHNEDYFVKLAVDIQKMGADVICIKDMANLLLPYKAYSLVKRLKKETDLPIVLHTHNTTGTGDMVLLKAIEAGVDVVDTCLSPLGSGTSQPATESLVATLKGTEYDTGFDLDLLAQLAAHFRTVADRLTKDGWRDPARVLGVDVKTLQYQVPGGMLSNLIGQLKQANQMDKYYDVLAEVPRVRKDFGYPPLVTPTSQIVGTQAVMNVLGGERYKMVPKESKDLLAGHYGRLPGKVNEDVRKKCIGDTKVITHRYADDIPPELDKLREEMREWYQCEEDVLSYAMFPKVAPKFFEYRAAQQLKVDSTMLNKADKTMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAJ8</accession>
    <name>R7IAJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage II sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000093">
        <property type="protein sequence ID" value="CDE48293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48293">
        <property type="protein sequence ID" value="CDE48293"/>
        <property type="gene ID" value="BN770_01624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="581"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="726" mass="76955" checksum="777E214E6CBF2918" modified="2013-07-24" version="1">MTEVLTREKKAAWTAWRSAYKSGTGRKILRQTGRILLGAAPGFALAFSDICGVSAGAWAAYGMAAASCGLVTYPVSLGIAAAFLMRMLWGLTTRWELLIGAVLVLLSPHVLRQRNGAFPLIATSLALLPGAIIGVWQGSAATLLFGIGTILLGTLSAPVMRRAIESIRGGKSFETLESRLSVGYLLLMLLCGGARMMLPYVNLGVTAAGLMTMAAAVYLGVCPGCVMGLMAGVTLALQGLPLSVTVALSLGGFLAGMGQMTGRRMVPCILFALGMGGMLAYTGTIAWGALGAAAAAPLIMGVLPREADEFLRQQTRRFHPLPDAPGDAYAAYALRRWEKTVGDMARAVPSPVGLGEKRTPQWWEEHLCASCPERASCGCMNTELGQSRAEYIWKAHEASDEVWAQRLESLRGLGCARLYQLMDSMNLLRAENADEQRIIRRACQQRDMLVTHLTALSGSARHLAALSSGESWWDEQYARKLRHALAEEEAMARLSFVRQVDGHLQVAYELHGAGSADEQAAQLCGITSRCLGKPMTIAERERAHVRLTEMPLMMVEAGAASRCIAGADICGDTFSLGQLQDGRFVAALSDGMGHGNQAALESRQAVELLRMCLDAGYDRAQTLTAVNGMMLLAGQGERVTTGGLFLVGLSVHDGGFVPAGLVDGQGIAGQARRGGQLPDAGGRLVAVGRRRAAAGDTGERRKRGKADAAASGGHADSALRRRGGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAS3</accession>
    <name>R7IAS3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase class 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48675">
        <property type="protein sequence ID" value="CDE48675"/>
        <property type="gene ID" value="BN770_01784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="2">
        <location>
            <begin position="153"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="541" mass="60536" checksum="88B229A17A6CF920" modified="2013-07-24" version="1">MEQEEKKPTTLTGVDLSQTASLLLPWTHDPWGKLRPPLSEEALCMSAELASAAYGMAIEPWVEAGWRDVTIQVDGELTALPPNNPLSAEWRKYWVRARLKPVSALGQMLGALRLSSSNNTTGKAVVMLHPALDGRYVVAIGFMGTGSRFYDWFSNFRMTTQDGMHRGFLELARQFEANEEKISFPETAEELGLEKLTLRDILQNMRSPNSRFVLWVCGHSQGAAMMQVYAHLKMNETGISARNLIGYGFASPTVMAGKAVRDPSAYPLYNILNSDDLVPHCGAAVHLGMCLKYQATENLRKSCYNWKRDEKSVQARLAIRPVLWKMVDTPTCIIGGMALLMALGRVSGADFLKMLGLGGFLPLDRALEKADAEDFVRGLNQKAAAAYESVTGHPIDMGQVSDEANAMQRIIDHFGLLSFIDAAKALMTCPHYMMAHPEEGYIGTYFYIVMNGIQDFVPFIWRSGDPPRRMTVEQLPHDMVTQDMPGLYNRRLQKPDRRKHLPITRRDPRPGGDTRHHLPLLTAGTVQPNEKIYPVEDIELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAW3</accession>
    <name>R7IAW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48631">
        <property type="protein sequence ID" value="CDE48631"/>
        <property type="gene ID" value="BN770_01755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="30711" checksum="8A99AAA99EC65CB2" modified="2013-07-24" version="1">MAKTLYCKKCNMDVPEGEACPVCGKTPPASSMRVAWMYARQRALDWMSWNAVMRIAVPVLAAATVLGLVLELLLGGGAGVRQLLNSGFLWVMGMLLLFVAAVTLLVFALGGADELYCVVDSRGFHVRTALPGANRVKLWMHGKSAALMDTADTNGRVIISEKDLAWKDIARVQLWTDKRLMLLYSPRWWMKLSVPILLAKWNDVLTMVDEKLGKKKAVELPEDWAHQLPPQRVQEKKARKTAIETDVIPPQTTLPEDEEDYRPLDEVLEELRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAW6</accession>
    <name>R7IAW6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000108">
        <property type="protein sequence ID" value="CDE48438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48438">
        <property type="protein sequence ID" value="CDE48438"/>
        <property type="gene ID" value="BN770_01701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="283" mass="32163" checksum="75C8B2CAD89A9897" modified="2013-07-24" version="1">MHSSKHTKHFIYPRRDAWFLLPGFLGFALWYLVPFGMSLAASVMENSANAHFAGLENYAAVMQNSYFRLGFGNTLRFFAVAVALSLVIGFLLANMIFWHSRRRISWLTLVLLIPIFLPTAAIVPLWKVMMGGSSWLMRTLKPRDADWKYITLLTLYLWKNIGAVNLLFLIGLQGIEPSVFDAASVDGASHRTIAIRIALPMLCTVTLFAIIYLAMNGMRIFRESYLLYGMYPPKPLYFIQNYVNNHFTKLDYGLLSAGSSLFALVMTGLFLCIWGFLQRKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBG2</accession>
    <name>R7IBG2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48816">
        <property type="protein sequence ID" value="CDE48816"/>
        <property type="gene ID" value="BN770_01835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016718">
        <property type="entry name" value="rRNA_m1G-MeTrfase_A_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018249">
        <property type="entry name" value="MyrA_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="3">
        <location>
            <begin position="97"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="276" mass="30342" checksum="1C09B1B8A1FBA661" modified="2013-07-24" version="1">MLSKREKLFAAVSDLHGLICPVCRRLLSRQGDNLICAGGHAVNVNRRGCVNLLSAQADTFYDAALFAARERVFAAGCYQPVADAIDALLPDAPQKLLDAGCGEGWYLNALLTRRTDSIGAGIDISRDAILQATNQPCQAVWCVGDLRRLPFADGTFSAVLDVLTPANYDEFRRVLSPEGMLVKVYPGQDYLREIRAARGMSAYEEGQVDAYLREKAQLVKSVRVHETLPVSPELWGDFVRMTPLNHDLSAAEKDALAQKADVHVTVDLHVALCRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBM9</accession>
    <name>R7IBM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49289">
        <property type="protein sequence ID" value="CDE49289"/>
        <property type="gene ID" value="BN770_01959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16794" checksum="E5DB4A2C7A9B4406" modified="2013-07-24" version="1">MQSVQQDFDFIFIDCPPSLGLLTINALGAADSVLIPIQCEYYALEGVASLMNTISRVKKTINPHLEIEGVLLTMLDGRTNLGLQVVDEVKKHFKKQVYATVIPRSVRLGEAPSHGEPIHVYDKRSAGCVAYVNLAKEVLKRNNIKVKEFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBU0</accession>
    <name>R7IBU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48956">
        <property type="protein sequence ID" value="CDE48956"/>
        <property type="gene ID" value="BN770_01886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="130" mass="14056" checksum="6DEEA79AE867CB97" modified="2013-07-24" version="1">MDTQTNTAADSLAEILHALRGIRAPIQQGEYDLHALVRTALAESGIPCAHEVPLAPRCRIDLVCPGGIGIEIKRGQPDRKRIVMQLTRYAACGQISSLILVTERTVAVPNVIHGKPVSCVCLNRLWGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBV6</accession>
    <name>R7IBV6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">BN770_01913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49075">
        <property type="protein sequence ID" value="CDE49075"/>
        <property type="gene ID" value="BN770_01913"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="189"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE49075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="358" mass="38884" checksum="0A9BE3346DB371B9" modified="2013-07-24" version="1">MKRKIVLTGGGTMGHVTPNLALLPHLLAAGYEVHYIGTENGMEAEKLRNVPGVIYHGVKTGKLRRYFDWKNFTDPFRVAAGAFQSAHLMGKIKPDVCFSKGGFVAVPVVFGAWLHHVPVVCHESDLTPGLANKLSRPFVKRIATTFPECAQMLGAKAEMVGTPLRPELFRGSRAKGLSFLHFDGTKPVLLMMGGSLGAQAVNKALRDALPMLTGTFDVAHICGKGNLDPTLDKTPGYTQVEFLDKELPDVLAAADLVLSRAGSNALMEFQALARPLLLVPYPKGASRGDQILNAQSLEKRGLCHVLLQENMTPQTLTDALMQTWAERDKLTAAVKNAPPADGTKRVLEMIEEVQTRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBZ1</accession>
    <name>R7IBZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48803">
        <property type="protein sequence ID" value="CDE48803"/>
        <property type="gene ID" value="BN770_01822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001681">
        <property type="term" value="F:sialate O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="PTHR22901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="92"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="284"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="505" mass="55755" checksum="B16D670F6742A65F" modified="2013-07-24" version="1">MAIEFKLAPLFGNGAVLCRRKEVRVWGTAADGQTITGRVTTADGLILSEGICTARDGRFLLHLPPMEQATGCTLTVHCGAETCTSTDISIGEVYLASGQSNMELELQNADEGQDLISAHDDPLVHYFNVPKKSVWDDDAIAAEAASHWERVRPGYARDMSAVAYFFARKLARTIDCPIGIIDCYWGGTSVTCWMDKEALEATAEGQRYITRYREQGGDKPFDQWRQEEDAFWVEMNAWNAHVAQLKRKKPGVSWPEINETVGPCPWHPPVGPGSPYRPGGLIETMTKRVVPATLTGILYYQGEDDTARTEHYDVLLTAMVMRLRQLFRDDSLPFLNVQLPMWIAAGDEDKHDWARLRLAQARAASALQPGGLAILLDCGEFDNIHPTDKRTPGERLCDVALRVVYGMDAPESPRALGKYTQGDTLVVTLSAPVLHRETGELLLEIAGEDGAYHPVQSVTLAGAEMRLRSVAVLHPAKVRYAYVNWGKVALFGRNGLPLAPFAFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC03</accession>
    <name>R7IC03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpB</name>
        <name evidence="7" type="ORF">BN770_02003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49409">
        <property type="protein sequence ID" value="CDE49409"/>
        <property type="gene ID" value="BN770_02003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="6">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="5">
        <location>
            <begin position="131"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="461" mass="50802" checksum="EE309E426AE968CF" modified="2013-07-24" version="1">MLKEYHTIKEVVGPLMLVEGVSGVTYNELVEIHQSNGEVRSGKVLEVDGDKAMVQLFESSNGLRISDSTARFLGRGIELSVSMDMLGRVFDGMGKPKDGGPELIPEMRMDINGEPLNPAARNYPSEFIQTGISAIDGLNTLVRGQKLPVFSGSGLPHAQLATQIARQARVLGKGDRFAVVFGAIGITYEEADYFISDFRRTGAIERAVLFMNLANDPAIERIATPKMALTAAEYLAYEKGMHVLVILTDITNYCEALREVSAARKEVPGRRGYPGYLYTDLASMYERAGRVVGKEGSITQIPILTMPEDDKTHPIPDLTGYITEGQIILSRELFRKGIEPPIDVMPSLSRLKDKGIGEGKTRKDHAATMNQLFAAYSRGKEAKELAVILGDAALTDVDKKYAAFADAFEKEYVSQGFETNRSIEETLDIGWKLLAMLPRGELKRIRDDMLDEFLPKAEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC27</accession>
    <name>R7IC27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49434">
        <property type="protein sequence ID" value="CDE49434"/>
        <property type="gene ID" value="BN770_02014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13124">
        <property type="entry name" value="MATE_SpoVB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="369"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="523" mass="56024" checksum="D2C38283FAE334F6" modified="2013-07-24" version="1">MASKSKSIIGGMTVLGIAGIICKLVGVLFSIPLTYVIGAQGQGIYNAVFPTYNLLLTISSAGLPVAVSRMVSSALAKDDPHSAKHVFRVALLLLTTLGCLAAIIMLAGSGMLAARVNQPDSKIGFQVIAPCVAIVCMMSAFRGFIQGQQNMVPTAISQLIEQVGKVFLALPMAYIGNQMGGVAMGAAGALLGTTIVEGIALLYMILLYFRRRSRFDAIPQLAPEQNASTKRIAEQLMVIAIPITIGSCIVPLSQFIDSAMLVNRCVVSGLTHDAAVETYGVFSGMVIRLINIPTALSLAVSMSLVPAISSAWAVQDMDAVQRQTNLGLRFAFLIGLPCSVGMSVLSEQIFRFFYQGSLSEENIMTGSTLLMVSSLTVVLFTVVQATSSILQGVRKQRIPMYTLVAGVVCKIALNYTLVGIPGFNIHGAPISSLVCYTVSLVPNLYYVMKYTGTKFNWRDWLVRPGIATLAMGAAVCLMTRILPFSRLLTIVEVAVGIAVFVVTAIWTKALTKEDLNAFRRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC32</accession>
    <name>R7IC32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49439">
        <property type="protein sequence ID" value="CDE49439"/>
        <property type="gene ID" value="BN770_02019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="91" mass="10569" checksum="ED7A892551729732" modified="2013-07-24" version="1">MKYRKQYINVDVVFDTSGRMRPQVIHWVDGRRYEISRVKAIVPAAARKSGGQGDRYTVMLAGQERYLFFERPTDERAAIVGRWFVEATEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICA2</accession>
    <name>R7ICA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein involved in the export of O-antigen and teichoic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48132">
        <property type="protein sequence ID" value="CDE48132"/>
        <property type="gene ID" value="BN770_01548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="512" mass="58417" checksum="657CFF1B18145343" modified="2013-07-24" version="1">MRKKNSIINMIVGLVGQLLNMLLSFGGRMVFVHYLSQEYLGVNGLFGDVLGMLNLAELGIGSAMIFSMYRPAAQNDEQQLARLMNLYRTLYRIVALAVLGIGLALMPFLPRLMKGGEGIENLQLIYLLYLLQAVTSYLLSYKNAIYQAYQKAYIRKAVDQIIGIVRLILQIVVLVTTRNFILYLIIQLFMPMLTSAIIWARADREFPYLKQYKELPEPQERKAIFKNVGALSLHKLATVIVRSTDNLIMSAFDGLATVGIYSNYKLVLMNVNNLLGHVTGAFTASIGNLNALEGRKRVYEIFRILDFAAFLLYGYLSGGLVTLINFFIRMIFGEEYLFSMTVVVIIIAEFFISGLRQMGLQFREALGLFWHDRYKALAEAIINLVVSLILVRRFGVAGIIGGTIISSLLTCVWFEPYVLMRYGIEEDWQKKLRRYFMDYIVRWVVVAGVSAVSYWIFQLMPQTNFLWFIVQGLIYTAIFAAVVLVVYGRTKEFQYLLEMTVRKLRKKLHSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICC2</accession>
    <name>R7ICC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48943">
        <property type="protein sequence ID" value="CDE48943"/>
        <property type="gene ID" value="BN770_01875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="132" mass="14514" checksum="3BD93B5BCB3E9CDA" modified="2013-07-24" version="1">MSEPEVLLRVPGDRQYALAIRTALGGVAILKDLDADTLDDLRMAADEMCDCLLHQGRTVDHLEVAVYDEGDYLKVAISACYGEKKCPCEDETEITRAVLQTLASDVEMTRCGDCVQCITLLLHKATAPLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICC6</accession>
    <name>R7ICC6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48948">
        <property type="protein sequence ID" value="CDE48948"/>
        <property type="gene ID" value="BN770_01880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="402"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="630" mass="66086" checksum="E7AAD04D9E59B059" modified="2013-07-24" version="1">MSPIAARKKTIIWMIAAIVLAVSSIALGAGLIVSHNSLTDTRNQLTDTQSALSSTQSTLADAENSLSAAKDTLASTEADLSAAKETLDTTAANLADTQTTLAETQGTLADRETELSATKDTLASTEATLAETQGTLADRETELSATKDTLASTEATLAETQGTLADRETELSATKDTLASTEATLAETQGTLADRETELSATKDTLASTEATLAETQGTLADRETELSATKDTLASTEATLAETQTALSSRDTTLASTKDTLMITQTKLAAVKDTLSTTQNELDTLKASLPAKEYELENTKEALAATEAELAVTQDTLTAAQTELSDTKTSLSATETELTTTKDTLADATTELSDTKTALTATEAELTTTKDTLTAKEFELTATKDTLTAKEAELTTTKDSLTAKEAELTATKDTLSAKEAELTATKDSLTAKEAELAATKDSLTAKEAELTATKDSLTTATTELEATKATLAATEAELTTTQETLADAQAILAASNESLSFAKLNPATRGTDPGIAPSPMASAVRDPSEAVAFLLVTVGTKTYEPIPLLEDGYYRLIHGVCVNIIHVTETSIEMTDASCADHDCIAQGIVTLENKDTREGGSYIICQQNFVTLRLCTRAELEAEGIVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICV1</accession>
    <name>R7ICV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid ABC transporter substrate-binding protein PAAT family (TC 3.A.1.3.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000099">
        <property type="protein sequence ID" value="CDE48352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48352">
        <property type="protein sequence ID" value="CDE48352"/>
        <property type="gene ID" value="BN770_01670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448171" evidence="2">
        <location>
            <begin position="33"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="40"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="273" mass="30554" checksum="EF3D47A2A7EDD801" modified="2013-07-24" version="1">MREQKWNLGRFIGRSSALLLLFALLFLPSARAEEGENLPKIIIGSDEYQPYSYYNVDGSPQGVDVEMAREAFRRMGYAPVFRHVAWEDKDEALEDGTVDCLWSGFMMNNCEDKYTWARLNLFSRLVAVVRADSAYADLADLAGCRAAVQATSWAEYLLIRQDQPGIPKVKTVYSFSSMEEVFAVMRKGYADTIVGHECVLNIFLAENEGRYRKLETLLGTAELGVAFQKGTHEKLARQLEQTLAEMAADGTMAEILTAYGINGIVRMGGIESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICY3</accession>
    <name>R7ICY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_02108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49729">
        <property type="protein sequence ID" value="CDE49729"/>
        <property type="gene ID" value="BN770_02108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="302"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="396" mass="41930" checksum="4C45DDC50BCB25A0" modified="2013-07-24" version="1">MLKESIRMSWQNIRGNKMRTFLTMLGIIIGVTAIIALITTVGSATGEITSQFSALGAGKVSVSISGTAIKHGLNESDLAHIAALDNVAGVDPNVSLRTYAAQDGQLVEDVTLEGRSNDYFSVQDDLIGRGRALKAIDMDRSSHVCIIDQTLASAAFPNEDPLGQSLILHGQQFTVVGVLSEDSGSDLMAAMSASSDGGKAIVPYPAAMRLSGSNTVRSLTLYLKDSSLSSETVDNVKQLLDSAFNYRDSAYSIINLDSLLDTMNSITGMMTTMLAGIASIALLVGGIGIMNMMLVSVSERTTEIGLRKALGARPGLIQMQFLMESVMLSLMGGFIGILVGNLVSWMIAMALDITFQLNAGAITLAFVFSASVGILFGWAPARKASRLNPIDALRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID96</accession>
    <name>R7ID96_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49263">
        <property type="protein sequence ID" value="CDE49263"/>
        <property type="gene ID" value="BN770_01956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="680" mass="76676" checksum="0BEDDE496CC610F4" modified="2013-07-24" version="1">MDPTRFTHPIDLHAVSITDPFWQRETELVRREVIPYQWDALNDRIPGAEKSWCMHNFRLAGRIMAQSRQQGAQYTPQAYTYRGYDALPDDPAHPDEDKFYGFVFQDTDFSKWIEAVGYSLIQHPDEALEATADEAIDVVCAAQTPEGYLDTYYIINGMDGVFQSLRDHHELYCLGHLIEGAVSYYQATGKDKLLRAACRFADYVADFFGTADGQCKGYPGHEIAEMALVRLYEVTQDEKYLRLSRFFINERGQEPNYFVEEERRNAEREHRPVQSVNLAYHQAVKPVREQDEAIGHAVRAVYLYSGMADVARMTGDDSLKSACERLWRSIVQEKLYITGGIGATQIGEAFSYAYDLPNDTAYSETCAAIGLAFFARRMLQMSPQREYGDVMELALYNTVLSGMALDGKSFFYVNPLSVVPSACHADSRLQHVKTVRQKWFGCACCPPNIARIVSSIAAYAFTENEDTLLTHLYLGGSIRKTFPTGTLTLSIASDMPWDGHITVTLHADSPVSGTLGFRLPGWCPNPNVTADKPVRVADGYAYLSGEWHDGETIVLDFPMPVRLNRANNRVREDMRQVAVTRGPVTFCAEQADNGENLHLLRVNAEKFGKDGEGVQVLPDSRFGHRTVKLLVPGFRQQEDAEGALYVAYQSAEESPCQIELIPYYAWCNRGEGEMRVWLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDA7</accession>
    <name>R7IDA7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sigA</name>
        <name evidence="9" type="ORF">BN770_02134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49784">
        <property type="protein sequence ID" value="CDE49784"/>
        <property type="gene ID" value="BN770_02134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="217"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="306"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="371" mass="42110" checksum="5CC3A029EDAD9A80" modified="2013-07-24" version="1">MTLSQNGRPSPLDELYEYAKNKGTITYQEVTDRLGNTFFEADQLEKVLDKLESLGVTVVDSAEIPDTSPAAMEVPDPALNDDLSEADVISADDPVRMYLKEIGRIPLLTSEAEIEVAKQLESDDPAIRNEAKRRLSEANLRLVVSIAKKYVGRSKNSMSLLDLIQEGNLGLMKAVEKFDYTKGFKFSTYATWWIRQAITRSIADQARTIRIPVHMVETINRIVRVNRQLQQKLGREPRPEEIAKELGISVSKVQEIIKIAQEPVSLESPIGEEEDSHLGDFLEDDKTPPPSQIVAESMMKQTLSDVLHMLTPREEQVIRMRYGLDDGQQRTLEEVGKAFNVTRERIRQIEVKALRKIKRPNMSKNLVDYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDD5</accession>
    <name>R7IDD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49456">
        <property type="protein sequence ID" value="CDE49456"/>
        <property type="gene ID" value="BN770_02027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="276" mass="30040" checksum="9CDF5682E88050B9" modified="2013-07-24" version="1">MMVGHPVKLNIERTEPVNPRPRIEVKDLIVRNEEGTTKLDHVSFTANSGEILGIAGIAGSGQKELLEAIAGLQPVDSGSISYIEDDGTHVELIGKDPLTIQNMGVSLSFVPEDRLGMGLVGNMDLSDNMMLRTFRKGHSFFTDRKSPRKIAENVVKELEVATPSLNTPIRRLSGGNVQKVLVGREITSAPKVLLTAYAVRGLDIHSSYTIYNLINNQKKQNVAVVYVGEDLDVLVELCDRILVLCGGKVSGIVPGRGADKREIGMMMTRVGGNEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDF6</accession>
    <name>R7IDF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49839">
        <property type="protein sequence ID" value="CDE49839"/>
        <property type="gene ID" value="BN770_02158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435800" evidence="1">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="255" mass="28407" checksum="3873332B7BA5C514" modified="2013-07-24" version="1">MKKAFRYLLPLLLLMLLTLPALADGYEFADDLTGEYLYPAGSDESTATYIYRYRYPQLAGDDEIAAMFNTTYAYTADDTLAFEAPMNAGLTDGAAQATIIDVTYEVTCQTADYLSILITKHTKRPDSESTTISGHVFALTGSRAGEIISLPYLLGILTQDGKVDTWLQDRQTAKADNCVRELVWAEIERMMKSGDVPFYDGLTFEELEAAFYPEEDFYLDENGDPVFYLLENTVALPEAGILLVPISLETLLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDG1</accession>
    <name>R7IDG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49670">
        <property type="protein sequence ID" value="CDE49670"/>
        <property type="gene ID" value="BN770_02086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="172" mass="18855" checksum="9559484B1326252F" modified="2013-07-24" version="1">MFFIALVAATYLPFQAILIPLLQTINALDLYDNLWGLVLVHAVFGMPMCTVMMRGYYADVPDALIRQAMIDGNGVWQIYRKIVLPNTKIATITVFVFQCTSIWNEMLFALVLGGYDSKPATIALNELAGTMAAEFNVQMAGSLILALPVLVLYIFMGKYLISGQMSGAVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDU4</accession>
    <name>R7IDU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49616">
        <property type="protein sequence ID" value="CDE49616"/>
        <property type="gene ID" value="BN770_02051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="331" mass="37646" checksum="7FDC7B9152AF74AF" modified="2013-07-24" version="1">MAQENNTAREQTELEKLSQDALNQARRERKMIQDTCIAELAQCDTEIPEALEKQVQAEIASLQQAKENLSSAHKIASSTVDELSARAADVAKSLNRKWYRINPPSNTAIDVQEEEKSFFARGMNGYKIALIVFIGSFAGVMLELLWCFARHGYLESRSGLVWGPFNMLYGVGAASLSIILYRFRNRGKWLSFLGGFVVGSVVEYVCSWLQEVLFGSRSWDYSRVPFNINGRICLLYSLFWGALGILWIKDIYPLMAKWILKLPNRAGKILTWVLSIFLAVNCLVSAAAVYRWSERLHDEPPKTWIGSVMDARFPNERMERIYANMNFGDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDX2</accession>
    <name>R7IDX2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">clpB</name>
        <name evidence="12" type="ORF">BN770_01805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48747">
        <property type="protein sequence ID" value="CDE48747"/>
        <property type="gene ID" value="BN770_01805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="416"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE48747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="866" mass="97554" checksum="48BC3C72BD925240" modified="2013-07-24" version="1">MNTNQFTQKTMEALQRAQQIAVEYQHMQVDEEHMLLSLTEDAKALIPQLLTRCGISVDAFRAALNDALSRIPRVSGPGREADKVYISPDFEKALLEAENRAKQMKDEYLSVEHVFLGIASKPNAHVKEILTRMGYDEKKFLKELSAVRGATRVTTDNPEETYDALKKYGSDLVEMARQHKLDPVIGRDSEIRNVIRILSRKTKNNPVLIGEPGVGKTAIAEGLAQRIVHGDVPDSLKDKTIFSLDMGSLIAGAKFRGEFEERLKAVLAEIKRSEGRILLFIDELHTIVGAGKADGAMDAGNLLKPMLARGELHCIGATTLNEYRQYIEKDAALERRFQPVMVGEPSVEDTIAILRGLKERYEVFHGVKIQDNALIAAATLSNRYITDRFLPDKAIDLVDEACAMIRTEIDSMPTEMDDINRHIMQLEIEEAALKKDDDELTKARLAEVQKELAEQRDEFNQMKAKWESEKNAITKVNKLREEIERVNAEMERAERQYDLNKAAELKYGELPKLKKELAAEEAIAEKSKGEDSLLRDKVTEEEIARIVGRWTGIPVAKLMEGEREKLLHLEDTLHQRVIGQDEAVKRVSEAILRSRAGIQDPNRPLGSFLFLGPTGVGKTELAKALAQALFDDEKNMVRIDMSEYMEKFSVSRLIGAPPGYVGYDEGGQLTEAVRRHPYSVVLFDEVEKAHPDVFNVLLQVLDDGRITDSQGRTVDFKNTILIMTSNLGSEYILNGIANDDITPEARAQVDALLKTHFRPEFLNRIDEIVYYKPLTKEQISKIVLLMLDSLNKRLADRQLKVELTDAAMNAVIDQGFDPVYGARPLKRFIQSKIETLVAKHIIAADVKPGDTLTIDVNENGELYMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDZ5</accession>
    <name>R7IDZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49835">
        <property type="protein sequence ID" value="CDE49835"/>
        <property type="gene ID" value="BN770_02156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="597" mass="66367" checksum="EF373B6725C72CB5" modified="2013-07-24" version="1">MKCPQCGQWNRASLPNCIRCGAPLNPESAETPAWQEQFRKEDKEPKKYIHVDEDGAVDESSDRRDELATDMTELKERKVRGARRLERMKEEAAMRSAPSGATTIHMHSSRESLMNAHVGRVRMVGHEDERNASAQSAAMADNVVPQPKIWQDTRGYDPLVTMLQENTIPSAPPRMNEMKSYRTRGKGFRVTLRVLIILLVVGLVGVGGFFALSHLGLLNTSSGSNASITSSIVDDLAAHTVLIPGEDGQQIYVGAPMQATYPVVDGFATVEIPDYLWYRDLPSVGVENETMHVTLKAFLKTANGRQKALDPIEYDISIPLSPIALVSPESMRQEVTTAMYSVQLQVRPGSTVTVNEVDISDTVSEDGLLIYNATVQPIGDNVFKFRVRAPYCRENALDLTLYREVQEIPLDLAVTTYASTSKSTLEISATTKPGATVDVLTNHSDLDITNLDKTGEFKFVAIFDKIGDNTITITSSYPGSKTSRVDYTIYYVPNQDVYTRKAWPLNNSAEYSELMSNITYRSEHSQVYLVVGTIAEIISTKPQTAIVYTGEDGQSRPVVIENKSKTDWAVGDYLRIYCDAYGTYSAMPWLIARYTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE23</accession>
    <name>R7IE23_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48812">
        <property type="protein sequence ID" value="CDE48812"/>
        <property type="gene ID" value="BN770_01831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="198" mass="21700" checksum="706DD72D3213722B" modified="2013-07-24" version="1">MQGISLLLNGEKLDTRLTRHVMLHKPAGLLTAARDKKQPTVMDLLPAEYAAIGCMPVGRLDKDTTGLLLLTTDGELNHRLLAPARHVDKTYLATLDKPVGDKEVAAFASGLSLSDFEAAPADLTPLPGNQARVTIHEGKFHQVKRMFAAVEREVLALHRETFGSLVLDEALPCGQWRELTEAEASALYRDAQMEEKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE85</accession>
    <name>R7IE85_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49935">
        <property type="protein sequence ID" value="CDE49935"/>
        <property type="gene ID" value="BN770_02196"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="187" mass="21469" checksum="2FD48957DB1662F5" modified="2013-07-24" version="1">MVQKFDFQPLDLQGAYRIKPFYATDNRGGLIKDYNVDTFRANGIDHDLKEVFYTISKRGVIRATHFQLVKQQAKLVRCISGHVYDVIVDLRPDSPTFGQWRGFHLTGENTEMLLVPQYFGHGYLVIEDSVVSYKCAEVFYGEGDSGIMYNDPDIGIEWPFELIGGKENLIISEKDLHLMSFADYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEG1</accession>
    <name>R7IEG1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="12" type="ORF">BN770_02097</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49713">
        <property type="protein sequence ID" value="CDE49713"/>
        <property type="gene ID" value="BN770_02097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="120"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="327"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="498"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="686" mass="78998" checksum="4C943A4D859D66D3" modified="2013-07-24" version="1">MLTCTENRELSWLRFNERVLEEAEDERVPLCERLSFLSIFQSNLDEFFMVRIGSLHDQMLLDKEARENKTNMTPGEQIDAAVSRIRTLCDRRDRTYADVLKKLEDEGISIVNFRQISSESEQYLAKIFREDYLPLLSTYVVGKKQTFPFLKNKEIYAVAVLRTGSEKEKIGIVPCGENMFPRLIEVPERTGCYILSEELILHYLPLLFGSYRIASKTLARITRSADIDADSVYDEDLNYRDHMAEVVRLRQKLCPVRLELSRKIGHDIIEKLCDQLKLDTARVYEYDTPLDISFLFNIQDKLRSHAELFYAPRHPQATPDIVDNRPVMEQILEKDVLLHYPYQSIRPFLRMLSEAANDPQVVSIRMTLYRLARDSKVVEALVEAAENGKQVDVLVELKARFDEENNIEWSRRLERAGCHVIYGVDKLKVHSKLCLITRKTDEGIQYITQIGTGNYNEKTSRLYTDLSYITARDEIGEEALQVFQALMLGETVDHMSVLLVAPHCLQDKLIDMIDGEISKAKAGQKGLIRLKMNSLTDKMLIDKLVEASQAGVQVEMIVRGICCLRGGVPGLTDNVHIISIVGRFLEHSRIYIFGDGDAARYYIASADWMTRNTLRRVEVATPILQDDVKRRIDHIFDVMWHDNVQARDQQSDGSYTRRYPGTQTPLASQNVLYDEAYRMAKGIKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEJ5</accession>
    <name>R7IEJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50060">
        <property type="protein sequence ID" value="CDE50060"/>
        <property type="gene ID" value="BN770_02261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="223" mass="26206" checksum="6AE7161C7F0C0B6E" modified="2013-07-24" version="1">MKNIRQPPMIHHCNQTEYIQRGASLAQMAADACAAMYLPDRMKKLLTFYADCPDGFFPALKTIHDETGMNESSICKARKELVDVGFILYTPEEIRIDWQRVAAMAMLPPEACFSLRRRSMPERAQVEKIKPAFWKREPMKWTTPKVYVIRPEWKYKSFKKPKHIRRRLGERKNKNSRMIQLCMTADSWKTCRKARIYKQLFAMKWGGKINLPACGIYHKIINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEM8</accession>
    <name>R7IEM8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50244">
        <property type="protein sequence ID" value="CDE50244"/>
        <property type="gene ID" value="BN770_02331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="295" mass="33095" checksum="62C5D05662F938C2" modified="2013-07-24" version="1">MEIGIRLHDTAGSNLEEHLRNAKEQGFSCVHIAMSKVVPGFKMADAPELLTDALADEVRGLLEKYNQRCVLLGCYLNLCSPDLSAHERTLMNYRAHLRFGKKIGALMVGTETGAPNIGYKSCPECRTEESLRLFIERVKPVVRWAEEEGMMLAIEPVMRHIVCTAERCQRVLAEVQSENLRVILDAVNLLDRENVHQVQEVVTDAIARLGDSAELLHIKDFLPDGTDECAWARQNIANVNMFDGLLSIAPGLGQMDYRPLMQLAKRRNLPMTLENTNPQNAVSARQTLEKTLEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEP3</accession>
    <name>R7IEP3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rlmN</name>
        <name evidence="13" type="ORF">BN770_02279</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50105">
        <property type="protein sequence ID" value="CDE50105"/>
        <property type="gene ID" value="BN770_02279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="95"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE50105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="351" mass="39333" checksum="13FD01DDD43AC29E" modified="2013-07-24" version="1">MTELTGMTPQELSDWCKAQGMPAFRGKQIFRWIHQGADFDAMTNLPAAMRAQLKEIAVAQPVSIIDERKSQIDDTVKFLFGLKDGNCVEGVLMHYHHGYTLCISTQVGCRMGCKFCASTLEGCVRSLTAGEMLGEVLAANRYLDGKDRVHNIVLMGSGEPLDNYDNVCRFLRLLREEDGVNIGLRNVSLSTCGLVPKMYQFAEENLPVTLSVSLHAPNDEIRRQTMPVANAYPMDELLAACRNYIDKTGRRVIFEYALVGGVNCEEKHAIELASRLRGMQCHVNLIPLNAVEERHLKGVNEQTVQRFLHKLEELHISATRRREMGDDIEGACGQLRRKTLTTLHDPQGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IET8</accession>
    <name>R7IET8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000134">
        <property type="protein sequence ID" value="CDE49097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49097">
        <property type="protein sequence ID" value="CDE49097"/>
        <property type="gene ID" value="BN770_01920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022595">
        <property type="entry name" value="Enc34_ssDNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10991">
        <property type="entry name" value="DUF2815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="73" mass="7855" checksum="892A0A580E4319F5" modified="2013-07-24" version="1">MVDADCNPILTRSEVYSGVYGRASISFYAFNSNGNRGIACGLNNLQKIRDGEPLGGRASAESDFADDDEDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEW1</accession>
    <name>R7IEW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49986">
        <property type="protein sequence ID" value="CDE49986"/>
        <property type="gene ID" value="BN770_02218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="385" mass="42712" checksum="86A160EAD854BFB6" modified="2013-07-24" version="1">MIRIAIVGTGNISHAHVEAYLRFPERCKIVALVDIVPEKAQKMKEDYHLTEAEVYDDHQKILSRKDIDLVDVCTPPYVHASISINSLRSGKNVVCEKPMAASLEECDEMLRARDESGKKLAIIAQNRFRQPISNLKKLLDSGLAGKVLCASVTSAWWRGHCYYDLWWRGTWEKEGGGCTLNHAVHHIDMLCWMMGLPQAVTSVMANVAHDNAEVEDLSLSVLQYPGALAQLTASVVHHGEEQELVFQCEKAKVAAPFSVYASISKPNGFPIENTELEQKIRDFVDAQPQLPYEGHAGELENVLSALENDTLPAIGGEDGRRTIELITAVYKSGATKQTVTLPLQKDDPFYTVEGMMRAVPHFYEKTTSAASLDGTITLGSDYQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF69</accession>
    <name>R7IF69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heavy-metal transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50454">
        <property type="protein sequence ID" value="CDE50454"/>
        <property type="gene ID" value="BN770_02400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436508" evidence="8">
        <location>
            <begin position="42"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="773"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="827" mass="87224" checksum="9E090092E5D51C5B" modified="2013-07-24" version="1">MKQYCVTGMSCAACAARVEKAVSAVPGVTSVSVSLLTNAMGVEGTAADGEIIRAVQDAGYGASVKGTESKQSASAAEEALEDHETPKLKRRLCWSLGFLMVLMYFSMGHMMWNWPLPAWFDGNHVAMGLTQMLLTIIIMVINQKFFISGFKALWHRSPNMDTLVALGATASFLYSTYALFAMTDAQLHGNMDAVMGYMHEFYFESAAMILTLITVGKMLEARSKGKTTDALKSLMKLAPKTANVLRDGQEVSLPIEQVQKGDVFVVRPGESIPVDGRVLDGMSAVNESALTGESVPVDKAAGDNVSAATVNQSGFLRCEATRVGEDTTLSQIIRMVSDAAATKAPIAKVADKVSGVFVPVVISIAVVTMSVWLLLGAPFGDALSRAIAVLVISCPCALGLATPVAIMVGNGVGAKNGILFKTAASLEETGKVQIVALDKTGTITSGQMRVTDVLPADGIGENDLLDAALSLETPSEHPLAKAVVQYALEKGRKAQDVADFAALPGNGLTAKRDGALLLGGSVKYMQGQCKVPETLLAAAEKLSGEGKTPLLFSRDGAILGMMAVADTVKDDSPEAVAELRKMGIRVVMITGDNPRTAQAVGQTAGVDQVVAGVLPDGKADVVRRLQKVGRAAMVGDGINDAPALTCADVGIAIGAGTDIAMDAADVVLMNSRLSDVPAAIRLSRATLRNIHENLFWAFCYNVIGIPLAAGVFISLLGWKLNPMFGAAAMSLSSFCVVSNALRLNLFRLRDGRHDRALHPVTLPNIAAQPGAKVLTMRIDGMMCAHCEARVKAALEAVDGVQSAAASHEKRCMACRARRKATKRVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF75</accession>
    <name>R7IF75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49988">
        <property type="protein sequence ID" value="CDE49988"/>
        <property type="gene ID" value="BN770_02220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="35985" checksum="BFEB9673AF028694" modified="2013-07-24" version="1">MTNPAKAPAPVQPRRKRGKHWLQRDWRLYLMLLIPIVWYILFCYKPMAGLQIAFQKYNMFNPAKSKWIWLDNFKFVFGMSDFGIALKNTLILNGLDLLFGFPVPIILAILLNEMRTPMLKKFSQTMLYLPHFLSWVIIGGMVLQIFAPTSGVINSTLLRWGWISENIPFLTDGPTWTFTYVLVGVWQSMGWGTILYLAAITGLDMNLFEAARIDGANKLQQIWHVTLPGIRSTIVVLLIMNIGRMMSIGFDRPFIIGNTKVKDYCDVISTFVYRAGITNSQFARATAIGLFQSIVGLVLITGANTVSRLFDEQSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF85</accession>
    <name>R7IF85_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TelA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE50003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50003">
        <property type="protein sequence ID" value="CDE50003"/>
        <property type="gene ID" value="BN770_02229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026508">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR026508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="380" mass="42789" checksum="F970E549B4904DA3" modified="2013-07-24" version="1">MAMNFNRPAGAPTTAVAAKPETALMEVQPYDIIADQQATQKQLAHSPEIESLTAGIDVNDLNTIVTFGSHSAEEISKASDVVLRSMNMSQLDESSKMLNSLAKIMDQFDINEIRDNPSLFGKLFGNLRKQLDKILAKYNTMGNEVDKIYVQLKQYEGEIKQSNQKLETMFQANVGYFHELEKYIVAGDQGCQEIQNYMTQLQQQMEATGDQSITFELQSLQQTLAMLEQRTQDLRTAESVALQSIPMIKTIQFSNMNLVRKINSAFIVTLPVFKQALAQAIMLKRQKIQADAISALDERTNEMLLKNARNTVEQAKITTRLASGSSIKADTLETTWRTIMTGLDETKKIQESARAQRAQDQAKLEAIKKDFMSHYNMPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFK8</accession>
    <name>R7IFK8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000161">
        <property type="protein sequence ID" value="CDE50118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50118">
        <property type="protein sequence ID" value="CDE50118"/>
        <property type="gene ID" value="BN770_02287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="481" mass="54192" checksum="14C1B934E2251A03" modified="2013-07-24" version="1">MLPKTGVTFSCDDAALQKLFDEAERKCLHNLKDFGADTVLVEGGGYEKIWLETQPMGGEMYWKRNMTAAMNNQLLFMRTQRADGRIAGSIQCHPDGTIEPQFNKFQGFCFPLHALNMWYLSGKEPAYLDMLADCLEKFDAYLWKTRDSDGDGCLESFCVYDTGEDNALRYGHAPVYCTTDTPPEDADVVPMASMDVTSFSYACRDTLAEISRLRGDGRESEWREKADAVAANLKARLWDDKRHACFDRDKHGKTIDVLCHNTLRCMYWGSISQEMADAFVRQHLLNPQEFWTPLPLPSVAVNDPMFRNAPENNWSGQCEGLTYQRAIIALERYGYEPLVTKLGRKLLDAIIRGGYVFTQQFDPFTGEPSRVGMVSHEVLSRDSDEPFQDSYGPTLLAALEYIAHIWGIALVGDEVWFSLGSGLSYTYAQRFGDDVYEIKSDGRSGSIYKNRIAVGSAPCGVRLVTNRDGKILRTVKIEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG88</accession>
    <name>R7IG88_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50476">
        <property type="protein sequence ID" value="CDE50476"/>
        <property type="gene ID" value="BN770_02410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008533">
        <property type="entry name" value="DUF815"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05673">
        <property type="entry name" value="DUF815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="235"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="477" mass="53746" checksum="9B0CE346511D9670" modified="2013-07-24" version="1">MYREVSQLLLYSNLGEDSILRQLSGIFSDWAHGECEKPVLVSRIYQQVKRLLDLATRYGFNCNLWHDYLTFVLMMNENSFSLTCERVGASDGSVNHFAKADFAVFKRLFDFDFAPIEQDLGIDCFTVLENYTAIPKKAQMYYRTVSEKVRALSAAIAGAKDENEIFDLVTAHYRDCGVGMFGLNRAFRIQEDENGSFTLNAINNIDSVLLSDLIGYEPQKKELRQNTEAFVSGRAANNVLLYGDAGTGKSTSVKAILNEYADRGLRMIEIYKHQFGLLSQVIAKIKNRNYRFMIFIDDLSFEEHEVEYKFLKAVIEGGVETRPANVLIVATSNRRHLVQETWKDRDDMEHNGDIHRSDTMEEKLSLAARFGCAICYVSPNRQQYHDIVRGIAARLPDGLTLTEDELLQAANRWEIRHGGVSGRTAQQFINYIAGMPEGVKGATGKPPCAPAGASPCNKNIQAAYNPQRGDVGNLHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH92</accession>
    <name>R7IH92_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-hydroxy-3-oxopropionate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000186">
        <property type="protein sequence ID" value="CDE50990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50990">
        <property type="protein sequence ID" value="CDE50990"/>
        <property type="gene ID" value="BN770_00260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006398">
        <property type="entry name" value="Tartro_sem_red"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01505">
        <property type="entry name" value="tartro_sem_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="4">
        <location>
            <begin position="164"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="294" mass="31202" checksum="B1CDD416C210E598" modified="2013-07-24" version="1">MKIAFIGLGIMGKPMAKNLIKAGHELFVFDRNPAANEEMKAAGANICASSADTVKNVDLVITMLPNSPQVKSVMLEEDKLADAMPKTAVFIDCSSINPVASREIAAELEKRGIDMLDAPVSGGQPKAIDGTLSFMVGGKEEVFNRFKPVLASMGSSVVLCGGIGAGNVTKLCNQTIVAVNIAVLAEAMQMGQMCGVEPQKIFEAIRGGLAGSTVMNAKAPMMMDQNFEPGFRIDLHIKDLKNVVDAASAVDAPIPLTQAVLEMMKVLHKDGCGACDHSALLKYYQKLTGEVLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHD6</accession>
    <name>R7IHD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51035">
        <property type="protein sequence ID" value="CDE51035"/>
        <property type="gene ID" value="BN770_00271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="51" mass="5783" checksum="4DAC0E058FAFD067" modified="2013-07-24" version="1">MDRKRPLHPSPLVKTLADAQRRMSHTDVLGSWTGVPWEDADEEPVQDADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHJ7</accession>
    <name>R7IHJ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uridine/cytidine kinase</fullName>
            <ecNumber evidence="2">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51234">
        <property type="protein sequence ID" value="CDE51234"/>
        <property type="gene ID" value="BN770_00339"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="5">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="207" mass="23588" checksum="66E10E036198CBE5" modified="2013-07-24" version="1">MILIGICGASGSGKSTLADALANRLGDRCLVIQQDCYYRDHPDLSFTERAKLNYDEPGIFDHDLLLHDMNTLISGQPITRKAYDYAQHRRADTDELIYPHDVVILEGIHCFFDPRLMKLMFLKLYMKVDADICLLRRIERDILERGRSIDSISDQYRATVRPMFSQYIANYVEFADIIVAGGGKNARIVDILAGYVSDELSKRAYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7II19</accession>
    <name>R7II19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP synthase A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_00439</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51439">
        <property type="protein sequence ID" value="CDE51439"/>
        <property type="gene ID" value="BN770_00439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE51439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="286" mass="30806" checksum="4C648410F5C876BE" modified="2013-07-24" version="1">MKQEKKNSRVRLILVMIVLLAALLAAIFLTDPGGEKTESIQAVMKDAVLHEDNQMAFLGMQVNPSVISDWVVTGMLLVVAALLRIFAIPHFNLVPGKLQSALEALVSFFRDMAKSYSPHRNGFLGVYIFSAGMYIAVGTLFELLGIQSVTTEGMSMSLPAPLSDINAAIAMGLMSYGVIMSGGIASNGGRGILLTLKEFSLPISMSFRLFGALLSGLLVSELVYYTISLSFVLPVLVGVLFTILHALIQTYVLTMLTANYYGEVSEPPKKKAKKEKKPAGAVPAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7II37</accession>
    <name>R7II37_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplK</name>
        <name evidence="9" type="ORF">BN770_00299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4 6">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000195">
        <property type="protein sequence ID" value="CDE51141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51141">
        <property type="protein sequence ID" value="CDE51141"/>
        <property type="gene ID" value="BN770_00299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="7">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="141" mass="15085" checksum="B1C1B120D02E2577" modified="2013-07-24" version="1">MAKKVTAFIKLQVAAGKANPAPPIGPALGQHGVNIPGFCKEFNERTKNEVGLVIPVVITVYSDRTFTFITKTPPVPVLIKKALNIETASGRPNRDKVGQLTKEQLRKIAETKMPDLNAASIEAAMSMVAGTARSMGVTVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IID9</accession>
    <name>R7IID9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51226">
        <property type="protein sequence ID" value="CDE51226"/>
        <property type="gene ID" value="BN770_00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="99" mass="11382" checksum="43226858AF138C28" modified="2013-07-24" version="1">MDSEKLTPEELTEEELTEEEPTEEELEEARRRLYAHLAQAEEDIKAGRVHPLDDAIDEIIRELDTYPENAPGLTDDEKIDIVAARILKEYKAAFEELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIF3</accession>
    <name>R7IIF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50362">
        <property type="protein sequence ID" value="CDE50362"/>
        <property type="gene ID" value="BN770_00177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="293" mass="33115" checksum="27E811CD0392C17F" modified="2013-07-24" version="1">MFGYVRPGLESLDEAQKKRYRAWYCGLCQSLGDRHGFRGRMTLTYDMTFLAIFLSALYEPAEAHGQMRCLPHPKEAHDFVRTSMTDYAADMTIALAYFKALDDWQDDRSLPGGLTAQLLKKRYEAVSADYPRQCADLEKNLRALSEVEAAHSDSPDAAANCFGALMASLFVREEDYWSRTLRLFGASLGRFIYMVDAACDYDADTRKHSYNPVLLMGRQPEDMRDVLTLLLGDASAAFESLPIVSDADILRNILYEGVWQSYNEFLHRRAEKQKKHSGNTTKENGDDSPVKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIF9</accession>
    <name>R7IIF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BN770_00029</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51103">
        <property type="protein sequence ID" value="CDE51103"/>
        <property type="gene ID" value="BN770_00029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="13">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="225"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="289"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE51103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="473" mass="52083" checksum="0BD2E80911509EB8" modified="2013-07-24" version="1">MSGDPWAGPLLLQLVLIFLSACYAAAEVALLSLNSTKLHHDAEEGDPTAAKLLRITDAPARTLSTIQVCITLFGFLGSALAATQFAPRLAGAILSAGAGIDAGVLNVLCVILITFLLSYLTLCLGTLVPKRLAMKNPEAIARRSLLLLEVSTVIFRPFVMLLNAATHGILRLCGIDPNATEDEVTEDDIRMMVDIGGENGAIEEAEKEMIENIFEFNNSTAEEVMTHRTDVTSIWVDDTEDEILRTICDSGLSRFPVYNENMDDIIGILNTRDFLLNAQSDNPKSLRALLREAYFVPETVQADQLFRNMQVKKIHMAIVVDEYGGMSGIVTMEDLLEEIVGNIYDEFDKQTEAEIVRAGDNTWRISGSTPLKDVNDALDLSLPEDEDYDTLGGLIFSQFTTIPQDGSTPDLDCFGLHIHVEKLEDHRVETALVTKLATEDDHADDHPETLLDRLRSRDDNDAQTDNGKGNEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIG5</accession>
    <name>R7IIG5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51108">
        <property type="protein sequence ID" value="CDE51108"/>
        <property type="gene ID" value="BN770_00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34640" checksum="0077A0DE3EE096C9" modified="2013-07-24" version="1">MKKYVLKRLLSLIPTIFIVSVVIFLLVHLTPGDPAAAMLGEDATAAEIAALHTQLGLDDPLVVQYFRWVGNCLRLDFGTSTAVVNKPVSEMIASHFQPTILLAIYSQLITILIAIPCGMLAAKKRGTIADYFVSVLSMLGISLPSFLMGLGMVLLFAVNLRVLPAAGYKNPFTDGFLPFLRYMTLPAVSLGFIHAGYMMRMTKASMLEVLGSDYIKMARSKGVREWKIVTKHTFRNALLTVITVVGQGFISALAGAAVVERLFNIPGMGSLMVDSIEKRDYQVIQAITLLIAMLNVFINLIIDLIYGLADPRIRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIM8</accession>
    <name>R7IIM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000224">
        <property type="protein sequence ID" value="CDE51485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51485">
        <property type="protein sequence ID" value="CDE51485"/>
        <property type="gene ID" value="BN770_00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="365" mass="40006" checksum="16BA341E211D9022" modified="2013-07-24" version="1">MNREPHFDENEVLRQCMSPLNEEVPDMPENFHAQWTALVKEDAMKQEETRKVAPMRRWTRILSVAAALVFVVGGTLLTKDSLSPARTSAPQSLADSYDYDYDTYTSDVGYSEEAGSGVRTMMVSAANDAMPEAASAKSAVAEDKKIIRNVSLTIKTSAYDDSMASLTALLSQYGGYLESSSEYTNNRDLRTASLTLRIPADSLDAFLSNTGELGRVTSRNMSSTDVTASYQDTAARLENQKLLLARLQALTDTAGDLSDLLALETQLADTQYNIEQLESALADTDQQVNDATVRVTLNEEAQPDLRDETVSLGERIKGALSTGWNAFVSFLQDCVVFLTAALPFIAIVAVMAIVIIIIRKAKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIP3</accession>
    <name>R7IIP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51649">
        <property type="protein sequence ID" value="CDE51649"/>
        <property type="gene ID" value="BN770_00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="322" mass="37359" checksum="1A6D17A47682E0E1" modified="2013-07-24" version="1">MILQMADPVKELKEIRFTSEKEMQHFCEKNMEQMLGLQFIASEFRVAQFRFDSVAYNPVSTAFNIIEYKNDKNFSVVDQGYSYISTLLQHKADFVLRYNQIFNINKRLEDFDWTQVRVLFIAPSYTVHQLNSINFNDLPMQLWRIKRYERGIIQFEQIKPTSTVASISGYSSMPANSVATKVTSAIGSAKAMEDAAKEIIVYTEEERLADGSDITREYYTELRDYILAFDDDIELKATKLYIGFFLRNRCIFSIKLQKNSILLWINALYGSLDDPKRLITDVTHKGHHGNGDCQIKIDDRANIGYVKDLINAFYKMKADENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIP9</accession>
    <name>R7IIP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51654">
        <property type="protein sequence ID" value="CDE51654"/>
        <property type="gene ID" value="BN770_00556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="248" mass="28456" checksum="0319E446FA5DF617" modified="2013-07-24" version="1">MYTGFAEVYDTLMNDVHYGAWADMYARMMTAYGIPRNAKVCECACGTGSLTLPLQQLGYEMMGIDLSQEMLWQAAQKARKAGFGIPFIRQDMRQLRLHRPVDAVLATCDGVNYLLQDVDAAAFFQSAWEAIKPGGGLFFDVSTPYKLEHLLGSQFMGEDRRDVTYMWQNRYFPERQQVEMHLAIFVKEPDGRYRRIDEEQVQRAYQAEKLVALLQSIGFVDVRVFGTNALTHPAPEEHRWHIAARKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIS0</accession>
    <name>R7IIS0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000226">
        <property type="protein sequence ID" value="CDE51530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51530">
        <property type="protein sequence ID" value="CDE51530"/>
        <property type="gene ID" value="BN770_00479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="6">
        <location>
            <begin position="423"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="797" mass="87918" checksum="66CFB2D45FD6421D" modified="2013-07-24" version="1">MLRYTKKGIESKERIGTLPLRMSNLLRYRGVNTPEEAERFLHPRLTDLLDPSTMPGMEKAVSIIRQAVREQWGITIYGDYDVDGICATSIMLETLRDLGAQHIRPYIPSRHEEGYGLNADAIELLAKESRLLLTVDCGITNLDEVALAKKRGMTVIVTDHHQLAEKLPEADAVLNPLIEPYAFKRLCGAGVALKITQALLGMDGVEKRIDLAALATVADIVPLMEENRVIVREGMMRMGTSARPGLKKLMELAQVSQPVNTGHLGFRLAPRLNAGGRLETAEQCVKLLTTKDEAEATAIATHLNGLNQERQAMEKQIVEQAISAIPAQVNFRTDFAIVILGQEWNNGVIGLAAGRICEKYHFPTIVLSQHGDLAVGSCRSIPGVDIHQMLTACKALYQAEGHGQLFERFGGHSQAAGLTIRAELVPELRRLLNRVIPQGDNCDLTCYIPQKEYELEVPLEAVNMALIDELNQLQPTGYGNPNPVLMARGLHVQEARRVGVGGAHLKLTLLDGANVRGGIGFQQGDLADRGYERVDVLFSPEVNEFRGQRTVQLNVAAMKQTGGSLLWPDEKMIFSALLQELTALASNYNTLSSGDTQAKILPLRTNQLREKLRLGRGVLMIAHQSAWAKDVLSGGEADTDVGQVRDARAFNTVLFAPDVEKLRDDWRDVVLLDGETLPGLKDIIRQKCPNARLWRLLDAPDDLRMQLSAMTVSEDTLRGLYRRLLRGGTMAASALAQDCGMTEEQVLTGLIVFGQVALVSFKLDPYQLTLLPMHKVALTDSPLRKYLITHYAAETQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIT5</accession>
    <name>R7IIT5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000228">
        <property type="protein sequence ID" value="CDE51545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51545">
        <property type="protein sequence ID" value="CDE51545"/>
        <property type="gene ID" value="BN770_00488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="471" mass="49094" checksum="5D5100B44E876F37" modified="2013-07-24" version="1">MATSKNTSALDRHFGYTAKGSSFKTECLAGLTTFFAMAYILMVNAGMFSSIPGVTYGAIYIATAISAVIGTVAIGLLANLPLAQASGMGLNAYFVYTVVLGLGFSYANALVLVLFDGILFILLTVTGLRKLIFQAIPQAVRVAIPAGIGLFIAFLGLQNAGIIIPSASTGVTLASFNLLANGWNVGIMAMVVTIVALLAIAIMSHRNVKGSVLLGIVGGTVLYYVLGFLTIPNFGADITMSSPFAAFNEFFSGAFGKVFTEGFNFAPYVEAHGVANTVLTIATTALAFCMVDMFDTIGTLYGACARGNMLTKDGEVPNMDKAMLADAIATTTGAICGTSTVTTFVESSSGVAEGGRTGLSSMVTALMFLVAMFLSPVAQLVPGCATAAALIYVGVLMMNCVKDIKWLDATEAVPAFLTLAIMPFAYNISYGICFGLLSYVVINLCTGKAKNIKAGTWVITALFVAMLLLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ45</accession>
    <name>R7IJ45_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">33 kDa chaperonin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 33 homolog</fullName>
            <shortName evidence="6">HSP33</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hslO</name>
        <name evidence="7" type="ORF">BN770_00557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSP33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51655">
        <property type="protein sequence ID" value="CDE51655"/>
        <property type="gene ID" value="BN770_00557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00498">
        <property type="entry name" value="Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00117">
        <property type="entry name" value="HslO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0862">Zinc</keyword>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="277"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33109" checksum="0B284DD7422B8710" modified="2013-07-24" version="1">MSEEMIERHQGDEMIRLTLMDGQVRVMMCETTQMAQRAADIHGATPVCTAAMGRLMTATSMLGVMMKGDNESVTVNIHGDGPMGTIVAVANHGDVKVCADDARVELPLRADGKLDVGGAIGHTGRMTVIKDLGLKEPYVGTIELVSGELGIDFAQYFTVSEQQPSLVSLGVLVNGDVVLKAGGLLVQPMPGCEEETIEQLELRSPMFADISREMTEAPKEQLLEDWFRGMKPVVLDRTPLRYHCGCSRARMEKALISLGRKELQNIIDEDTGAELGCHFCHQQYQFTTEELRQLLEKATRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ68</accession>
    <name>R7IJ68_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrimidine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="7">2.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_02462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:22824"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000175">
        <property type="protein sequence ID" value="CDE50642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50642">
        <property type="protein sequence ID" value="CDE50642"/>
        <property type="gene ID" value="BN770_02462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="11">
        <location>
            <begin position="345"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE50642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="442" mass="46541" checksum="7A2B2C8A76D841FB" modified="2013-07-24" version="1">MQILDIITKKKLGQPLTREEITFFARGAADKTIPDYQLAALLMAIRLNGMTAQETTDLTLAMRDSGDVCDLSAIPGKKIDKHSTGGVGDTTTLILAPLVAACGVPVAKMSGRGLGHTGGTLDKLESIPGLSVEETEERFIRQVQEIGLAVIGQTAALAPADKTLYALRDVTSTVDSLPLIAASIMSKKLASGADGIVLDVKTGSGALMETLPDALALAQTMVDIGKLAGRPVVAVITSMAQPLGTHIGNALEVKDAIDVLAGRTQGDLLEISLLLGSHMLVLAEKAKTLPEARAMLENALSSGAGLRKLAEMIAAQGGDPRVVEDLSLLPQAAVKRVMRAETAGYLSAMDTTALGMAAQRMGAGRAKKSDMLDYSVGYVLHVRLGDEVTEDTPLATLYARNEAEAEEAEKAIRKALTIAREKPQTPKLWDAVVTAEGIIYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJE5</accession>
    <name>R7IJE5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpC</name>
        <name evidence="10" type="ORF">BN770_00433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51433">
        <property type="protein sequence ID" value="CDE51433"/>
        <property type="gene ID" value="BN770_00433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="SSF46604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6 7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="8">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="138" mass="15322" checksum="686D10582839961D" modified="2013-07-24" version="1">MDTFQLNILSASSAFYEGECESLVVPTPDGKRGVLAHHSNAIAAISPGELSYTVPGEKPRLAAVSHGMIKIEDNHVLVLVETAEKPEDIDRIRNQQKADAAREALLQKQSRREYLETQAQLARALTRLRVKHHSENLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJW0</accession>
    <name>R7IJW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminopeptidase P domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51603">
        <property type="protein sequence ID" value="CDE51603"/>
        <property type="gene ID" value="BN770_00518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="422" mass="47677" checksum="1003A2F59A0413F0" modified="2013-07-24" version="1">MNASFHTGNRKRLYEAMKPASLLVMFSGEDVRKTNDEYYPFYTDRNFYYLTGLDQHELVLMAVKEPSGNVHEQIYILPPDLMAERWTGARLKPAEVEALSGISDVRFVNQFQTDFHALAAGGHYSLTSGQIAQVYLDLFRVSPQDIDRPAHRLLKQIQANYPYLQVENANAILRRLRLIKQPCEIDAIRQAEKVTGEGIMAMMKASRPGMYEYQYKAEFDYALTQHGPQGPAFPSIISAGKNNFCIHYYSYRGQAHDGDMVLNDVGAQHDSLMTDVSRGFPCNGRFSDKQKLLFNCALQTSNHMFSIVKPGFSMAEVDATIRRYNAALLCDAGVLDKPENIGRYMWHGGAHHVGYDVHDVIERPLTVKPGMVFCIDVGIYHEEWGIGFRLEDNLLVTEDGCENLSAAIPRTVEDIEAVMRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK36</accession>
    <name>R7IK36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type spermidine/putrescine transport system permease component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51811">
        <property type="protein sequence ID" value="CDE51811"/>
        <property type="gene ID" value="BN770_00623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="59"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="256" mass="28612" checksum="B216D1382D50F335" modified="2013-07-24" version="1">MKKFCKRAYLALILIFLYLPIIVLIVQSFNAGKSRAKWEGFSFRWYTELFQDTRIMNALTVTVTIALLAMVVATILGTLAAIGIHAMKKRPQSFMMTLTNLPNTMPDIVTGISLMLLFLFTKVDRGYVTMLLAHITFDTPYVILSVLPKLKQMNRHTYEAALDLGATPMYALFHVIIPECMPGIITGAMLAFTLSLDDFTISYFTTSPLVQNLSTLIYSAARRGIEPTLNALSALMFVALLVLLLIVNRRTASNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK88</accession>
    <name>R7IK88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA internalization-related competence protein ComEC/Rec2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000239">
        <property type="protein sequence ID" value="CDE51718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51718">
        <property type="protein sequence ID" value="CDE51718"/>
        <property type="gene ID" value="BN770_00582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="524"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="756" mass="81677" checksum="9D63FAEED0F66839" modified="2013-07-24" version="1">MMAGIALGFQAPTSAMPMLCVSAALAGLLLLGRRRTRAAGCLLLTFLLGAALGIRTANPTLPPEGDAQVTGVVAGEVDFRAEKGQVRVILRDVTLNGERIASGAYWTFYLKADEKIPDCLMPGARISMTAEVYHPQGQRNPHGYDFRQALRQKNILIGLYGAAKLQALPDGLSLYGLAARFNHRMAQTLRDVCGEKTGQLASAVLLGMRGEVPDEEQEQFRRLGIAHILSVSGFHVGVLVALLALLMMPVKHRRLRMALTLPMLLAYAFLTGGNAPAVRAVLLWAIVCWGRIRHKRVLMPHVLCASAMIQLMFAPAQLFSASFQMTYGVMAAICGITAQTAPNAQKKRGWKGKILSLLSVSAAAQFGVLLPELYWFGRVPLLGIAVNVLLVAGMNVLLLLDWVTLLLTPIPWLAALPGAATRAVSEGFLHLVNALGRFAPTLWTRQPDAWVVLGWLLVFAALLPFGKSRNRWQNRKKRLPMLAAGAGLMATILLPAPFSGTEYMTILLPAPFSGTEYMQLDMGDADAAVLRQEKHVLVVDAGEYGGDLASYLRAERLPVDLLVLTHLHSDHAGGVRELLDEGIPIRRCVMPSGALEADFDEEVLPLLARMEENGTVIETVCRGDILQWAEGKLTVLFPPEGFSASNANDGSMALLVEAEGVKLLLTGDLSARYGQYAAVSADVVKAAHHGSKNGTTQAFLDESAPTAVLVSTKRENAADYLRGITDADVYSTLESGAIIIRMADSCFTIEEFEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKK0</accession>
    <name>R7IKK0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000255">
        <property type="protein sequence ID" value="CDE52016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52016">
        <property type="protein sequence ID" value="CDE52016"/>
        <property type="gene ID" value="BN770_00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE52016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="148" mass="15889" checksum="E14F3C0DF6717B6C" modified="2013-07-24" version="1">MSESVRQPDMLPDRYESGTVNLPGIAGLYAGVKFVRAHRAEIEEYELALCDRLRARLREIPGVRILCDDGQAHMAITSIVVPGHDGGALADALDAADVAVRAGLHCAPTVHAWLGTLQSGAIRFSPGLYNTAQEMDDTALLLARLLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKX5</accession>
    <name>R7IKX5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51973">
        <property type="protein sequence ID" value="CDE51973"/>
        <property type="gene ID" value="BN770_00726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="56" mass="5643" checksum="C0EB2E1A6D67AD5B" modified="2013-07-24" version="1">MAYKISDACIMCGACAEGCPVNAISEGDTQYQIDPDVCVECGACAEVCPVGAPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL59</accession>
    <name>R7IL59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000214">
        <property type="protein sequence ID" value="CDE51347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51347">
        <property type="protein sequence ID" value="CDE51347"/>
        <property type="gene ID" value="BN770_00389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="391" mass="41813" checksum="9B0FC63384245A47" modified="2013-07-24" version="1">MKNYSKTLRACYLGLITQAIAANFAPLLFWSFHSDFNISLGQIALIPAVFYVTQLVVDLICAKYVDAIGYRKSIVASQLLAGLGLIGIAVLPNIVSPYIGILIGVFFYAFGSGLIEVLCSPIVEACPFEHKEKVMSLLHSFYCWGSVGVILLSTLYFAIFGIDKWQILACVWAIIPLYNIYNFATCPIERLVEDGQGMSLRQLLKKPIFAAAIILMICAGASEMSMAQWASAFAESALGLTKSVGDLAGACLFATTMGISRMLYGKFGEKIDLIKFMLISGVICVVSYLLAGLSAMPIWGLVGCVMCGFSVGIMWPGSISITAPRIPKGGTALFALLAMAGDMGGAFGPSVVGYFSQHAGDNLQAGLLTGCIFPLIMLATLIAMKKMTPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILC3</accession>
    <name>R7ILC3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51427">
        <property type="protein sequence ID" value="CDE51427"/>
        <property type="gene ID" value="BN770_00432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9036" checksum="1F48D265332726B5" modified="2013-07-24" version="1">MTANESIVETKAGVPFTAYVLLWNNGDDGITTVQAICDGEVIAEKIMAVNGGDWRVVEMELTIDQPGEHTLTVGTLTKTITIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILR9</accession>
    <name>R7ILR9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DMT(Drug/metabolite transporter) superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51577">
        <property type="protein sequence ID" value="CDE51577"/>
        <property type="gene ID" value="BN770_00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="147"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="294" mass="31204" checksum="46D1969EB8CF443B" modified="2013-07-24" version="1">MTKKQWIADGLLLAAAIIWGSAFAVVKNTLDSVPPSMMIALRFGIAALISGVILRKHLRGLTRGQVLMGLLVGVLTGLAYIVQTIGLQDTTAGKNAFLTTIYVLLVPFGSAVLFHEKLGARRYVAAVLMLLGIGILSLDGESGGLNRGDVLTLVCGVLYAAQIISVGRCNERMDTYALIVLEFAFAALTGLCWSLATERGMPIQWNMQSIGGILYVAVFSTMLASSCQNIAQKLAPTSHAALLMSLESVFGALSGVIFLGEKLTIRMGLGFLVIFAAVVLSETTASSKKFTENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILZ7</accession>
    <name>R7ILZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51652">
        <property type="protein sequence ID" value="CDE51652"/>
        <property type="gene ID" value="BN770_00554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006938">
        <property type="entry name" value="DUF624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04854">
        <property type="entry name" value="DUF624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="338" mass="38656" checksum="EAA8265F7740B72B" modified="2013-07-24" version="1">MFDKLMNSYYYGKSGKGDYTPDDLPKNRWQLFLEMLRTRMSGLCRMNLMYFVAWLPAMIAIALCVVSLIMTLAGTVQVDETGAVIDAIDQTALREAMQTSSDMIFVTLLILIPCIAITGPFTAGLSYVTRNWARDEHAFPWADYKDAIKANWKQGLLVSTITGCVPFLVYICWRFYGDMAVGNAVWVIPQMLILMLGILWALAVTYMYPMMVTYQMNFRTIIRNSFILAVGRLPGSVGIRLLHCVPTVLFTVIFLLTLQPWVLMLLFAYYLIFGFAFSRFITASFTNAVFDKYINSRIEGAQVNRGLSQENDDDDDDDDEQEEERELKPWENGYTDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMF9</accession>
    <name>R7IMF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51792">
        <property type="protein sequence ID" value="CDE51792"/>
        <property type="gene ID" value="BN770_00618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="279" mass="31682" checksum="0650AA8DC49AE68A" modified="2013-07-24" version="1">MSEKKKVGLDIARSSTLVQEYQVASWERNELPTTPELTAIDEKIAKDPENAELHKERGLLLAGLGYYREAAECYSRAIAINPFNWEYYRHRAHRFVSCGYFADGAADFTIASRLNPNDWNVWYHLGLSYFLLGMYDKADWAYTRCAALNKTADDICAVTDWHYMTLKRLGKDEEAAKLLDEITEDMPVSDEVANSYYQRLRVYKGLRAPETLFTNAGDGAGLDVITQGFGVANYYRMNGQEEKGVEMLKKVVYTAEHSKWYAAFGCLAARVDLKNIGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMJ1</accession>
    <name>R7IMJ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ORF">BN770_00642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51832">
        <property type="protein sequence ID" value="CDE51832"/>
        <property type="gene ID" value="BN770_00642"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="211" mass="22793" checksum="B2E3FCF94B7D5B34" modified="2013-07-24" version="1">MRIIGLTGGIACGKSTISLTLKSLGATIIDGDQLSRALTQPGGLALPAIRAEFGGEVFHADGTLDRRALGSLIFASDERRHALDDLMQPLLREMIEREILRAKEGGAKICVLDMPLLYEAGLDGLCNTVWCASLPRETQLARLMARDGFTREEAENRLRSQMDTAEKARRANVVIPTDGTIEETAALIPPLYAAELAKEGSHGKHTASQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMV3</accession>
    <name>R7IMV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51962">
        <property type="protein sequence ID" value="CDE51962"/>
        <property type="gene ID" value="BN770_00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="2">
        <location>
            <begin position="39"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="3">
        <location>
            <begin position="239"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="537" mass="58114" checksum="9DD0FB22EC7504A7" modified="2013-07-24" version="1">MKLSYQGIQDKQGYAAAQVALPQYDWAKMAEKTAEKPVWVHFGAGNIFRGFIAGLQQRLLNAGLAESGIVAAETFDYDIIDKIYVPHDSMTLMVSLKADGSTQKEVIASIAKGIKANCADEAQWQQLTDVFTAPSLQMASFTITEKGYALRNMKGELMPVVVSDMENGPKQAHHAMAVVAAMLYARYQAGAMPIAMVSMDNCSHNGEKLRASVMEIVAAWVKNGLVPADFEAYVNDEARVSFPWSMIDKITPRPAEIIEKQLMDAGFEDMQPVITSRNTYIAPFVNAEVPQYLVVEDRFPNGRPALDKAGVYLCDRKTVNDTERMKVTTCLNPLHTALAVYGCLLGYTSIAAEMKDAELVKLVKTIGYKEGLPVVTDPGIISPKAFIDEVVEQRLPNPFIPDTPQRIATDTSQKVGIRFGETIKSYMASDTLNPADLTAIPLALAGWIRYLIGVDDNGAPMNVSSDPMLSTLQAALAGVTLGQPDSVDGKLEGILGNASIFGVSLYTAGLADKVTADVKELLAGPGAVRATLKKHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I2K7</accession>
    <name>R7I2K7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000002">
        <property type="protein sequence ID" value="CDE46139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46139">
        <property type="protein sequence ID" value="CDE46139"/>
        <property type="gene ID" value="BN770_00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="305" mass="34538" checksum="FE911FF4A730D380" modified="2013-07-24" version="1">MKEPILVMMAAGMGSRYGGLKQLDPVGPDDEVILDYSLYDAYQAGFRRVVFLIKHEIEDAFKAMVGSRVPAGMEANYAFQQLDKLPEGFSVPEGRVKPWGTGHAVLCCREFLDAPFLVINADDYYGAGAFKLAYEYLRTLRGKRGEYFMVGYALKNTLTENGYVSRGVCTVNEFGFLKEVRERTHIIASCDGPLFTEDGEMYRRLPDDTTVSMNCWGFTPDFLDALAEGFVPFLNEAMENNPMKAEYYLPTAVSRQLDRHRATARVLTCPDRWYGVTYHEDRAVVAKAMLRKAEEGEYPRPLWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I302</accession>
    <name>R7I302_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46244">
        <property type="protein sequence ID" value="CDE46244"/>
        <property type="gene ID" value="BN770_00800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436102" evidence="1">
        <location>
            <begin position="27"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="501" mass="55532" checksum="A4588E2CD1A486AA" modified="2013-07-24" version="1">MKKLLAMATSLALLATSAIVPMTAAAAEEKEVTKPEKITIMVDTTLVNQANGRDAFEARWEELTGIDLVINQPDHSAYYDVMQQTMADPDQWPDVLIMSSTYYSDFAANGALWDMTEAWENSNTKNSGRFTGDSVIEGLKINGRLYGFSPARGNGCVTYVKKAWMDKAGITKAPTNWEEYAAMLDAFSKLGVDGKTTYGTSAAGFIGNEAPYTNYLPEFYQDAYPSFILKDGVYVDGFTQPEMEAALARLKEGYDKGWIDPTTLTNSTKDCRNKFYDEQFGVFTYWAGTWATNLKTNLEANGHDSELIALPPIAEVGAYFDRIPPVWCITSTCENPEGVFAYFIDTMLDGGDMQMLWTYGAEGTHWSRAAETVLDKTYEEGTFHFLENLEKAGTLYTKNHIDPMLSLASFAEGYPDPKSVKEEARAASELFNANSKLAAIVPTTEEMGEYGAELTQKKNELIANVIMGKLTYEQAMEQFESEGYAAQSQEIVDSLNALLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I389</accession>
    <name>R7I389_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46349">
        <property type="protein sequence ID" value="CDE46349"/>
        <property type="gene ID" value="BN770_00831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="91" mass="10378" checksum="75714A2D1B9515C8" modified="2013-07-24" version="1">MTYWGWLLVGIALLLTALSGTQTSLCQRMRSVPVYRGLTYWEVQQIAKAAPTSFTPCGEDTIRRWVSGRYQIALRFNRYDVCLGVEEEIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3P5</accession>
    <name>R7I3P5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46529">
        <property type="protein sequence ID" value="CDE46529"/>
        <property type="gene ID" value="BN770_00923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435399" evidence="1">
        <location>
            <begin position="24"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="3">
        <location>
            <begin position="219"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="372" mass="40766" checksum="DC293288C200A9AC" modified="2013-07-24" version="1">MTTKRLIAMIALAVLAVAVIVFAVREIRLYGDVQVEQSRTPTPVPGYGNVMQVTIDPSLPTPVPVLRSGAQGEAVWQLQERLQALGYLTGSVDGQFGPATKEAVQLFQRQHGLTADGIVGEDTRELLYSDSAQPYATPTPAPTQAAQVTEAPAADDMILLTAESENTIPVGFTADGLPLLVNRDSPLPDDYQPQQLVNMRDYCDSSIVSIKGSEIEGEQIAVDALLAMLMQAQSEGLTSWQISAGYRSVAYQQKLFDDKVYSYRQQGMTGAQARSAARKLVADPGCSEHHTGLAFDITVPGTSFGGTKQAKWLEEHCWEWGFILRYPADKTAITGITNEPWHFRYVGVDASMEMRETGECLEEYVERKQNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I585</accession>
    <name>R7I585_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46656">
        <property type="protein sequence ID" value="CDE46656"/>
        <property type="gene ID" value="BN770_00973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="146" mass="15644" checksum="3A5A044BCE35F0F8" modified="2013-07-24" version="1">MNKLTIIGNLARDPELRTVRDGISVCDFTVAVNRRGSRQNTANGQSDADFFRVTAWRQLGELCAKYLAKGRKVCVVGPVSARTYTANDGTTRVSLEVTADEVEFLSSRMDDGAPAYNNAAPSAAAAPAPTAQNNGFTAVETDELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5C3</accession>
    <name>R7I5C3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47079">
        <property type="protein sequence ID" value="CDE47079"/>
        <property type="gene ID" value="BN770_01135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="537" mass="58725" checksum="96E0FDCBAF9663D4" modified="2013-07-24" version="1">MANQKNGKNRGETPARRDGFYFDDDLDSVTAGLPTGDEPEEDEVPDLPPEEDNAPPTEGYNSTGIRMIGLNSTRSEQDDEGIDRGRRPARPTMEFYMEDNLEAEYAPEKETPPEEAPEAGSDAQIDRGYGQKNRAADEKKRGKKKKGHPVLRTILVWTVSVILLGIIGIMALSRTMYQDSSLLTLPENAISSAVTPVQTWFSGIVQSISDYFYMVRLRSNWEAEYNRVVAENMELASVVARNAELEKQLSQFTNMQEEIVTNANMNPLTAQVIAREQGTYFSVFTVNKGSRDGVEPYMAVTISGALVGFTETVYDTSCTVRTIIDSDASIAGMIQSSRDQGIVSGTLGVDGTALCRMYYLPDDSLPRPGDQVVTSGVGFSFPKGIPIGTVRESTRGMEGNKQYVVIEPQADFQHLEYVIILRYKPEAEAIEGRDSTAVYNEYVPLVTARPYPTLKIGSTLMFGATATPTEVPSVTPSPTASPTPSPSPTPSPVPTPRGTVYEYNSTLLNPTATPSPTPTPSPTPVRTLNPGDLDWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5D6</accession>
    <name>R7I5D6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="5" type="ORF">BN770_01001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46701">
        <property type="protein sequence ID" value="CDE46701"/>
        <property type="gene ID" value="BN770_01001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="4">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="186" mass="21022" checksum="F8B3EDD6D23AAF2B" modified="2013-07-24" version="1">MTVKEILDASKEKMSKSVAVYQNEMTSLRAGRANPRLLDRIMVDYYGTPTPLPQIGNINVPEARMIVIKPWEKKMISAIEKAIQKSDLGLNPTNDGEVVRLVFPDLNEERRKELTKMARKSAEGAKVAVRSIRRDAVEQIKKLKKDSLITEDEQRKAEDDAQKITDKAIKDIDGICAAKEKEIMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5F5</accession>
    <name>R7I5F5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major Facilitator Superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46493">
        <property type="protein sequence ID" value="CDE46493"/>
        <property type="gene ID" value="BN770_00902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="444" mass="47963" checksum="B3C74D546FCDCCAC" modified="2013-07-24" version="1">MKLNTKRTMLVGLAFLSICIFWQMYDSVMTLILTDTFHLNETIAGAVMAADNVLALFLLPLFGALSDKTNTRIGRRMPYIIGGTAAAVILMNLLPVLDNAYAASPSPLILGLFIAVLALLLVAMGVYRSPAVALMPDVTPKPLRSRGNAVINLMGAVGGILYLALAAVLYPASRKVAGHVDYQPLFIIVSLIMAVSVLVLALTVKEKRLSEENRALEKQHPDWNLAAKDESGNEVLPKEVKRSLTFLLASISLWFIAYNGVTTWFTKYIEQVMGEGLGGASTCLLVATAGAICSYIPIGALAAKIGRKRTIQLGVALLTLCFLLGFVLTCTSSVITPVMYVVFALVGLAWAAINVNSLPMVVEMCRGSDIGRFTGYYYTFSMVAQVVTPIAAGSLMRAIDYRVLFPYAAIFSALSFVTMCFVRHGDAKAEAKKGLEAFEDMDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5L9</accession>
    <name>R7I5L9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46766">
        <property type="protein sequence ID" value="CDE46766"/>
        <property type="gene ID" value="BN770_00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435500" evidence="1">
        <location>
            <begin position="23"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="449" mass="49778" checksum="50021802272315C0" modified="2013-07-24" version="1">MKKNLLMVLGMVMLMMLSVASADSGNAATLPDGIKQILNGSAWSSYEIGRVNYGSQLTEDGYDACAWYDEHGFSAAFVLMHSEKKNVLCIFEKNASGKWALKRQSSGVVKQGEWIPTVYTEAYGIYYLYYNDKSSYNPVFDITVTKKNNDWYVTEIGWEKDGVSMGIFPYENKIEYLKIVYTDGGSKSTRTTVEGVTPPTSFAEFSLDNIPMTPEKARAQLSLPPDIPQSAGEYSLPQPQNIKFTSNKKYAVYSGPGENYFRGGNGKAAVSTNDWIQVFGRENGWIMLQYDITSDHMRIGWIQESALPKNANVSDMQFSQAQVWTKVSSNLTDDPLFSAAAISAIPANTEVTRLATMGTWTYVEWNAANTQPMRGFVQSANLTNLSADDVQAIAVRTLSASGFNTGEQEASYSCQYDPETARWSVVVYVQHKYQTVVWVDDATGEGTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I664</accession>
    <name>R7I664_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47140">
        <property type="protein sequence ID" value="CDE47140"/>
        <property type="gene ID" value="BN770_00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="80" mass="9074" checksum="815AFF74B1523DE3" modified="2013-07-24" version="1">MKRALLWGIQFYRSAISPYKGGPRCRYTPTCSQYAQTAIERYGAVKGARLAAWRVLRCNPFSKGGYDPVPEDPCTTLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6V8</accession>
    <name>R7I6V8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47008">
        <property type="protein sequence ID" value="CDE47008"/>
        <property type="gene ID" value="BN770_01104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_67M" evidence="2">
        <location>
            <begin position="94"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67C" evidence="1">
        <location>
            <begin position="392"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="616" mass="70065" checksum="8A46F4CCB450D2E0" modified="2013-07-24" version="1">MANQWLSWLPFLPADVPADFAFPREVAAFELAQALPALSPNLHVSLAEDDSLGEGFHAVRRGDDVTIFGGKTGLLYGAYWLLMALASGSALPEDHSSAPQYALRMINCWDNADGNVERGYSGRSLFFQGGKLTYDPARMRQLGRMLASVGLNVLCINNVNVHDPAQLLIEDDLPDLAKLAAIFRPFGVRLMVSIDYSQPMRHGIPTADPLDERVQAWWKHQAEVVYAAIPDLAGFLVKADSEHRPGPFTYGRNHAEGANMLARALKPFGGMLVWRCFVYNCQQDWRDEKTDRPKAAYEHYVYLDGQFDDNVILQVKNGPFDFQVREPISPTLLAMPKTNLALEWQLAQEYTGQQIDIFAMPVMWQELFADMPRNSIMAMAAVSNLGNDACMTGHPFAALNFFAYGALAWDPDACQPDDIIHRWIRLTYRFAPDDENALADVLLGSRHAYEQYTAPLGICWMVTPNQHYGPSPDGYEYQAWGTYHKADRNAIGIDRTADGTGYVLQYPEALRRRFESTQTCPDELLLFFHRLPYTFKMRDGRTLIQRIYDDHFEGYEWVERAASILKALPLPDFDRALVDERIGRQLHNAREWRDIINTFFHRLSGIEDVHERKIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I700</accession>
    <name>R7I700_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000055">
        <property type="protein sequence ID" value="CDE47639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47639">
        <property type="protein sequence ID" value="CDE47639"/>
        <property type="gene ID" value="BN770_01320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436215" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="181" mass="20625" checksum="29408F2BD34508C2" modified="2013-07-24" version="1">MKKIIVFLLTALLMFSVAFADSVPTSKEDQMASLVKNFLEENEFPYEYDDYTFTVPFSVDNSMEYAFITVYIYDDMLSVSVDAPLHGTREVFEKMAVFTTLVNNEIYYAQFRLDLDGDEFYISCRSCNLVEDVLPGENELFYLFAMPHSYMEDYGDGIVAVLSGGDPYEAFETCQAAVDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I767</accession>
    <name>R7I767_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-strand binding protein/Primosomal replication protein n</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46362">
        <property type="protein sequence ID" value="CDE46362"/>
        <property type="gene ID" value="BN770_00843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26290" checksum="6D085CB63C040F7E" modified="2013-07-24" version="1">MEENGNFLHLSGVLTDNPVYGHEVFGEKFYYATLSVPRLSGAEDLLPITVSERLMDDTPLTIGSKLALDGQLRSYNKVIEGAGRLLITGFAQHLVDPDSDENPNQVQLTGALCKLPSYRTTPFGREIADLMLAVNRAYGKSDYIPCITWGRTARFASHLKVGDKVTLLGRFQSRAYQKQLPDGTVIGKTAYEVSVGRLTMADAAPQPAPFVIHPEETHTVETLVQPSTPVQVNPFTTPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I782</accession>
    <name>R7I782_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoenolpyruvate mutase</fullName>
            <ecNumber evidence="2">5.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.9" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47331">
        <property type="protein sequence ID" value="CDE47331"/>
        <property type="gene ID" value="BN770_01212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050188">
        <property type="term" value="F:phosphoenolpyruvate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012698">
        <property type="entry name" value="PEnolPyrv_PMutase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02320">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="430" mass="48098" checksum="95AE846C23E2624A" modified="2013-07-24" version="1">MKQVYICFSTDILHNGHIRILQRAAELGEVTVGLLTDEVVASYKHYPLIPLEERIAMFEGLKYVSRVVVQESLDYTDILNRLRPDIVVHGDDWLVGYQANIRQKVIETLKGWGGELVEFPYTHTATEETLSTLDQLLSLPETRRSRLRRLLHYKPCLSVMEAHDGLTGLIVEKTTVETPKGRRQFDAIWVSSLCDSTAKGKPDIELVDMTSRLNTLEEIMEVTTKPIILDGDTGGLVEHFVYNVQTLERTGISAVIIEDKQGLKKNSLFGTGAGQKQASIPDFCEKITAGKNAQKTKDFMIIARCESLILEQGLDDALTRCHAYVKAGADGIMIHSKAKTPDEVFAFCDAFRKDDPKTPLVVVPTTYNMTTEDELAAHGVNIVIHANHLIRSAFPAMQKTAQVILEHGRSHEADPYCMSIKEILTLLPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7C7</accession>
    <name>R7I7C7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47391">
        <property type="protein sequence ID" value="CDE47391"/>
        <property type="gene ID" value="BN770_01236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="271" mass="29183" checksum="B4C77E0E67743F8E" modified="2013-07-24" version="1">MDIQELQEVCRQVRRDIIIMTNKAGAGHPGGSLSATEALVALYFDVMKGIDPKDDKNPNRDRFVLSKGHAAPALYGTLCERGYFGREEFDHFRQLHGILQGHPDVKKCPGVDASTGSLGQGISIAVGMALGAKKTGNPCHVYTIIGDGESQEGLVWEASMAAAHYHLDNLTVIFDHNGLQIDGSNDEVMSLGDIQAKFKAFGYDVIDVADGNDMRQVLDALHAPACPGKPRLIHLHTLKGKGVSFMEGQVGWHGKAPNAEQTAQALSELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7F8</accession>
    <name>R7I7F8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46457">
        <property type="protein sequence ID" value="CDE46457"/>
        <property type="gene ID" value="BN770_00872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447600" evidence="1">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="36"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27367" checksum="C97F53FDB1E3E8B0" modified="2013-07-24" version="1">MGRRGTLLLMIFLLLGCACAEKAVDITYRFGSREEQKIAVTIDDCYHAEDVRAVLDILQANDVRATFFPIGKALKYEDAALWQEVVASGCEIGNHSWGHTYLTKLSRQKIKFQMLRTQEKVDALLDCHYPMQVMRPPMGKTNPKVEESVAAVGYLAVVKWDVSETDPVKALADVQNGSILLFHARKKDAKCLSVLIPQLVAEGYQLVTVSELLGLPEIVCSAEKYVYHRRDTEENIRPDAVPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7N5</accession>
    <name>R7I7N5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">BN770_01191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47268">
        <property type="protein sequence ID" value="CDE47268"/>
        <property type="gene ID" value="BN770_01191"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="136"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="294" mass="30913" checksum="1D005E46A76891F7" modified="2013-07-24" version="1">MAAQILDGKAISAELRGTIAQRVARLREKGVTPGLAVILVGADPASQIYVRNKSGGWDQVGIXXXXVGCDQVGIHSVTINLPETTTQDELEKLIARLNADDTIHGILVQLPLPKHLDEAAALAVIAPEKDVDGFHLLNAGRMMSGQPGVVACTPKGAMEMIRRTGIDLDGKEAVVVGRSNIVGKPMAMLLLQANCTVTICHSHTVNLAQHTRNADILVAAVGKPGFITKRMVKPGAVVIDVGINRVNGKVVGDVMPDVADVAGYITPVPGGVGKMTIVELLENTVEAAEKQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7S8</accession>
    <name>R7I7S8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">dITP/XTP pyrophosphatase</fullName>
                <ecNumber evidence="10">3.6.1.66</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Non-canonical purine NTP pyrophosphatase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Non-standard purine NTP pyrophosphatase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Nucleoside-triphosphate diphosphatase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Nucleoside-triphosphate pyrophosphatase</fullName>
                <shortName evidence="10">NTPase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Ribonuclease PH</fullName>
                <shortName evidence="9">RNase PH</shortName>
                <ecNumber evidence="9">2.7.7.56</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">tRNA nucleotidyltransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="9" type="primary">rph</name>
        <name evidence="14" type="ORF">BN770_00939</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="10"/>
    <dbReference type="EC" id="2.7.7.56" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46572">
        <property type="protein sequence ID" value="CDE46572"/>
        <property type="gene ID" value="BN770_00939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="12">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="13">
        <location>
            <begin position="158"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="9">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="253"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="398"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="426"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE46572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="443" mass="47520" checksum="D41C26C623BEE67A" modified="2013-07-24" version="1">MLTRNDGRAPEMGRPVTIETDFVRTADGSCLICTGNTKVICTASVEENVPPFLRGKGQGWVTAEYAMLPASTGHRKQRDGVKRDGRGVEISRLIGRSLRQAVDLTALGERTITLDCDVLQADGGTRTAAITGAMVALVCAVSKLLDEGKLLRSPITHQIAAISVGVVDDTPCVDLCYEEDSRAQVDMNIVMNEKGEFVELQGTGEGRSFTQAELNALLDMGAKGIRALMEKQKDSLAESKRHLSAKPTLVVASSNQHKIRELQHIFGDYYTVVSMVAAGFNAPIEETATTFAGNAAIKAETVSAATGLPTLADDSGLSVEVLDGDPGVYSARYAMMAGEGSGDAANNALLLRRMKGKTDRSCAFICALALKIPGRETLIAEGSCPGVLLEEERGTGGFGYDPLFLYEPLNKTFAEVTEEEKNQISHRARACEKMLEIMKGLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7U2</accession>
    <name>R7I7U2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Capsule synthesis protein CapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000043">
        <property type="protein sequence ID" value="CDE47338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47338">
        <property type="protein sequence ID" value="CDE47338"/>
        <property type="gene ID" value="BN770_01214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435510" evidence="3">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="4">
        <location>
            <begin position="72"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="385" mass="43399" checksum="9F338073CC80C00B" modified="2013-07-24" version="1">MRRITALLLMLLLLPGLVAAEDDFDLDDILSDVDPDVVKNTYSQPGNADDILLDENNEPVSIYEEDGSILITLTATGDFTVGGDSRKSTNIWMNELKKHDNDYNFALANVRDIFLADDLTIVNFEGTLTDSTYVPSEKRNNEFLFSASPDHVSMLVDNGIEAVSLENNHVLDHGQAVYEETQQHLEDAGIVWSNSTHVGVMEVKGIQIAMLSYLCIDRYNTLWDQVPKDIAAAKEQYPIVIVNFHWGNEKDYSPTQNQIKMGRLAVDSGADLVLGHHSHRMNPIEYYNGVYICYSLGNFCFAGNSKPSDMSSFMFQTRWRIRDDEITNEGFRIIPIRISSRTDRNDFTPTVFGDGAARDAVLTTLKNNGKSLEYVVSEYPLEWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I828</accession>
    <name>R7I828_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48029">
        <property type="protein sequence ID" value="CDE48029"/>
        <property type="gene ID" value="BN770_01505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436243" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130090" checksum="8A36AE83DA3A45BC" modified="2013-07-24" version="1">MKRIARWSTIFLLLCSIIWAGTASAAMIVNNNMSALNTLNTINNNQTPQGKDSALERLAKEIGAGIWDNTDLDDPAFQENIKQFGITVLNKDTQPPESFIGDAIFDHLGDTEFNAPEMNGNLLVLGGLNANLPSGKIDRLYVLSDEDVRLNIGAAADVQELILGASGNVSLNGEGNVRSTIVVDKPMNLDIGIATNLVNLTDDPLPTGDIVLNPGKNALVPGQQLHMGSELKVEKKISLTVRFCLVDQSAKDMQLETADWDGALLTETTVQYTGDSCPMGAVNMMDSIEAAFAEKYPDLQEQYVLLPEMRSADPWSKVYRLNGGESCFAVAENYVYLSREGDVAFPLTDDSTLVAEFPVYVYRYGEQDGRITYRVRISGARPDYFTPSLTLRSGAVASFTFDKERGEWVTQFKRSDFGADERALIHLTGLRGEETDTFLPVTGREERRIVTLTWTADAQRVTIDAQNVLWGSDMPAEGNDLLCRAGEQVTVQIAPAAGYRGIHVFLSDPAISLSISEGNDAVSFLMPYAPLTLTLTADKLYTVTMDTAGGDPIRPIQYTVESEAFQLPTPVRTGYIFLGWTGEGITEPQETIEIPQGSTGDRTYTANWQVIEYTITLLHMDGAGTSEALVYTVEQAVTLPTPTREGYAFLGWTVNSDMAPQLTVVLPQGSIGNKTYTANWELTGYTVTMNLNGGSGETTLLYTVEDEEFALPTPTRNGYEFVGWTGEGIIMPQLNVTIPTGSTGDKAYTANWQVIEYTITLDTNGGPNVSPIKYTVEDSFTLPYPLRPGYEFAGWTLDGSGMLPATDLHYKAEWRLAEYTINMDLNGGSGKEKVVYTITDEDFELPTPTRNGYEFVGWTGERITTPQTSVKIPKGSTGNKAYTANWQVIKYTIITLLEGGNAGSSGAYVYTVEETFTLPTPTRTGYTFWGWTGEGITKPQPSVTIPRGSTGDKTYIENWVETGYTITLDLNGGSGKEKVIYTMTDEDFELPTPTRNGYEFVGWTGERITTPQTSVKIPKGSTGNKAYTANWKVIRYTITLVTNGGAVIASIRYTVEDSVTLPIPPERPGYEFAGWVLDGSGQFPSTPMIIPEGSTGDRIYEAEWRVATYTITYVSHGKAYNWVQYTIKNQVYFGAPEEDPSYYLPGYTFVGWKIDGVEGTPRSYMLPKGSYGNRTATMLWEPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I833</accession>
    <name>R7I833_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47448">
        <property type="protein sequence ID" value="CDE47448"/>
        <property type="gene ID" value="BN770_01250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="50"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="695" mass="79035" checksum="3641C9C2A214FE4D" modified="2013-07-24" version="1">MSMISRYIFGTPLPTMAVIREIAPSGGEIPHFTVTKADGSVSFTTLLGDDDLIFGLGENVRGINKRGHLYRAWNMDDFSHTENKGGIYSSHNLLLFSGEQGVFGAYFDDPGAVTFDLGYSDGGKAVITSENGNLSVYLIESTTLTGLVREFRHLIGRSYIPPKWAMGYIQSRWGYASEDDLNFIVSEHRKRHIPLDNVCMDIDYMEDFKDFTWNPVHFPDLKATNARMKDEHIHLVPIIDAGIKQLTGDPIYDEGVQKDYFVKKADGSLFVGAVWPGRACFPDFLREDVRQWFGAKYHKLMDTGIEGFWNDMNEPALFYSTDSLENAFETAEKMRHENLGIDGAFKLKDAFVNLANNAEDYRRFYHTVDGQPVRHDKVHNLYGAMMTKSAAEGFRSYNPDRRYLLFSRSSFIGAHRDGGVWQGDNSSWWSHLLLNLKMMPSLNMCGFLYTGADLGGFSCNTTEDLLLRWLALGVFTPLMRNHTAQHTRDQEIFRFRNWEDMRNVVSVRYALLPYLYSLLVKCACRDEMMFRPLAFDYPQDKTAIRVEDQLMLGDECMIAPVVEQNARGRHVYLPEDMLLVRFRSGDDYTVQTMQKGHHWLDVPMNEVPLFIRRGHVIPLCRSAEYVDALDTTKLSLVGWLEVGCAITLYEDDGESTDIDLNEGLQLINVSIDKGVATAKCAGKTIDASKVVVWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I843</accession>
    <name>R7I843_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47745">
        <property type="protein sequence ID" value="CDE47745"/>
        <property type="gene ID" value="BN770_01332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="647" mass="74101" checksum="9E0A465F83F044FE" modified="2013-07-24" version="1">MDNLKYLEHVVELGKVQAATTPEEMSGAFDAFNGFLGLYYDLAKMELQKAGIDTPPIRNFAIDKALERIDARLDCADFTIPALIRMLREHRGTRLNEEQAQKIEQSLIHFKYWLDEPGDVHACFFTENHQILYHSAEYLVGQMYPDVVFPNNGMTGAEHHAHATAFLRRWLNWRERFGFSEWLTQGYYMDDMLGLVNLMIYADEADIRTRCRMLIDMLVFDLAVNHFEGHLPTTHGRVYTRFIIEPDYEDCSAVMALLFDKGYAGTMSNCAVMLAANGYVCPKAILAAAAAPTGIQTNRERMSIDVADAKYYGVDPADFDNIMFFWGQQTYSDRLTIENSLKVFPTWNWMTNRVRAYYERYKLHDEAGAPCVDAPDFTAMTQVDIYTRRTPDYILSCAQDFRKGRMGYQQHPWTASLGGKAVIFTTNPASTEYSNRPNCWAGNLTLPRAVQHENVLLCLYRVEPDFVDYLYSHLYFPRHEMDEVVEKEGWIFGRKGDGYAAVYSLLPGYWEKKDPAMFKALYAESWQEKYDRADDYEYIAQGHANVWVIEMGSKAENGSFEAFMDGFAGKKVCGDTHNLIYQSPSQGEITFGWNRPLTVGGETICIHGYKRYDNEFAQTEFDAGAIEINAGGHQTILDFEKAERTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8E4</accession>
    <name>R7I8E4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase family 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47746">
        <property type="protein sequence ID" value="CDE47746"/>
        <property type="gene ID" value="BN770_01333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="681" mass="76424" checksum="7EDD0BBDB7A58B1B" modified="2013-07-24" version="1">MGYYFDDRNSAAWSYGDDAGRIIDLLGTRFMGENPVTPFIWRTFDESGIQADRKARYLLDFARRFPGGENGEIVYAAADLYCPQAKSSGFVVECDGPVQVWLNEERVFQSNGNQERTHEKCRIDVSLRAGYNRFVWRCERTEIGFGCAFANAMPQWEPCNYVLPYKEYDGEAGILYTEPVDERMQIDVGSFFGDFMPPELTWLPRAEKKSLVGAGVYAAWLKGSVRVPLAAHDAVTLIVDGKPGRVIPGAQHDVVAVGPYQAVAALVSDSDWAWRKPPVHIHGRTTPYLIMGPLKTADTSAFTACAMGQLVEGAEGTITWRTGFDGVALRPYVESKLFGRWTYPLGVTLYGMWQAGHFLSREVMNDYVTSHADQVVSIHEYALYDQARYGFPGVNQQICWLDALDDCGSFGSMMLECAKPGDAAVRKLADAIGEYMLHEQPRTSEGAYCRRDDTIWADDMYMSGPFLCRYSELTGSMEGMNACANQLLQYKDLLFMPDKQIMSHMRCLRNGKSNRIPWSRGNGWVLFTLSELLQKLPVGHEKRPALLLFFRELSAGYMKLQDASGLWHQILDEPGTYLESSVTAMFICAFSRGLRNGWYDVAVLDEVRSAVERAWKGLCEQAIDRDGNLYGVCRGSGFSFSRAYYRTLMWNFNDTHGIGIVMLAGVEYLKLTTKAYGAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8F0</accession>
    <name>R7I8F0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Phosphate propanoyltransferase</fullName>
            <ecNumber evidence="4 7">2.3.1.222</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>phosphate + propanoyl-CoA = CoA + propanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:28046"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58933"/>
            <dbReference type="EC" id="2.3.1.222"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Polyol metabolism; 1,2-propanediol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PduL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.222" evidence="4 7"/>
    <dbReference type="EMBL" id="CBJB010000070">
        <property type="protein sequence ID" value="CDE47885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47885">
        <property type="protein sequence ID" value="CDE47885"/>
        <property type="gene ID" value="BN770_01413"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00621"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051144">
        <property type="term" value="P:propanediol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008300">
        <property type="entry name" value="PTAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39453">
        <property type="entry name" value="PTHR39453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06130">
        <property type="entry name" value="PTAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010130">
        <property type="entry name" value="PduL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="190" mass="20165" checksum="043C848D64C58840" modified="2013-07-24" version="1">MKQFIVETSARHVHVTQQDLETLFGKGYELTVKKMLSQPGQYASAERVDVVGPKKTLTGVSILGPVRSATQVELSLTDARSIGVTAPVRESGDIAGSGACKLVGPAGEVELTEGVIAAKRHIHMTPADAEEYGVKDKDVVSVKVDTDGRSLIFGDVVVRVSDKYALAMHIDTDESNAAGCGRAQMGEIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8H7</accession>
    <name>R7I8H7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UPF0122 protein BN770_01029</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPF0122 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46807">
        <property type="protein sequence ID" value="CDE46807"/>
        <property type="gene ID" value="BN770_01029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00245">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007394">
        <property type="entry name" value="UPF0122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40083">
        <property type="entry name" value="PTHR40083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04297">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="119" mass="13844" checksum="C9E13AB3C1304373" modified="2013-07-24" version="1">MAQDEISKKVELNWLSAFYGGLLTDKQRQVLTLHCEEDLSLTEIAQEVGISRQGVHELLTRAARKMFEMEEKLHVAARFQRVENGLEKCRAMMREGRYDDAERMIDALIRFDQEENNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8I5</accession>
    <name>R7I8I5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="17" type="ORF">BN770_01034</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46817">
        <property type="protein sequence ID" value="CDE46817"/>
        <property type="gene ID" value="BN770_01034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="29"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="138"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDE46817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="245" mass="27238" checksum="C1A2ED13C676F667" modified="2013-07-24" version="1">MSEAPAMKITILTIFPEMFESVLNSSILGRARAQGILDIRCVDIRPFSDRKHKNTDDYPFGGGAGMVMLAQPILDAMRSVTGDDFQGRRIYLGPRGRTLSTAVARELAQERELVLLCGHYEGVDQRALDTCIDEEISIGDYILTGGELAAMVLTDCVARFIPGVLGSAESPEEESFSDGLLEYPQYTRPRELNGMEVPDVLLSGDHAKIKAWRRIESLRATKRHRPDLLASAELTDKEKRLLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8K7</accession>
    <name>R7I8K7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="9" type="ORF">BN770_01445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47945">
        <property type="protein sequence ID" value="CDE47945"/>
        <property type="gene ID" value="BN770_01445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="443" mass="48805" checksum="4CFB981069F3F633" modified="2013-07-24" version="1">MAKDDMTRTPLKRCSFCGKTERQVMRMVAGANNVCICNECIMLCQEIISDAMPMMHSGHPQQEQKFDHLPSPAEMKQVLDDYVIGQEHAKRALCVAVYNHYKRIGQRPGKDDVELQKSNILMVGPTGCGKTFLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLRLIQAADYDIDAAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTLASVPPQGGRKHPQQEMIQIDTTNILFICGGAFDGIVPIIESRTGKKNLGFGAELTSKTPEGSTDALKKLRPEDLTKFGLIPEFVGRLPITVTLDALDEDALVRILTEPKNALCKQYQKLLGLDGVELTFDDDAVRAIAHMAIERKCGARGLRAIIEDVMLDTMFDLPGRREICGCEITADSVNGKCEPKLIEGKRHKLGGRTAKRKMEENTLVEQPDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8K8</accession>
    <name>R7I8K8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46842">
        <property type="protein sequence ID" value="CDE46842"/>
        <property type="gene ID" value="BN770_01050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="269" mass="30356" checksum="108B19ACDA4E9E1E" modified="2013-07-24" version="1">MWKLLKYEFRRARTSLLTVLGVIAVLEMYFLISLGVDHMEHVVIAAVLMMFASYGAAVYIFVRGVASYASELKAKSAYLIFMTPNSGLKIMGSKYLYTFVNGILLGGVCGALGALDLSLIMMHEDDWQSFLRMMDIFLRVNQGVQTGQIVLAVAFYLVLMLLSLLTFFAMAYFAITLSHTLFRDKKWRTWVALLIFVGVYWGLSYLQGLLPNPVENLVFNTMYDPNAEITVTTFADMIPQMLPYALYDLAIVLLSLFGCGWMLDKKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8L5</accession>
    <name>R7I8L5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000089">
        <property type="protein sequence ID" value="CDE48214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48214">
        <property type="protein sequence ID" value="CDE48214"/>
        <property type="gene ID" value="BN770_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436261" evidence="1">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="200" mass="22444" checksum="2ABC99BB56EEDA12" modified="2013-07-24" version="1">MKRFLAVLMLVVMLCGCVGLAEEQKFDYTVLEKLEGYSYDKFEKTWSYYGAYAKKYSDARLVIGIQVYGDKDSVLAVQFYAKAVDNKNETYSMVEEVSILADDTLITCKLMPIDGGQVTLVLTSNADALQAIANAKEISFKVKMKLGSITLEPTMEDLADFITVIKTICEYNILSYSTNFGYDTATIQILEKNFPITVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8P5</accession>
    <name>R7I8P5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000028">
        <property type="protein sequence ID" value="CDE46887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46887">
        <property type="protein sequence ID" value="CDE46887"/>
        <property type="gene ID" value="BN770_01070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00185">
        <property type="entry name" value="tRNA_yibK_trmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="172" mass="19573" checksum="8CDB2EF2CE4A4236" modified="2013-07-24" version="1">MMNIVLFNPEIPQNTGNIARTCAATGATLHLIEPLGFSLSDKYLKRAGLDYWNLMTYHTYPDFGEFLRQHPDARMHFASTKAPRGYHEATYQDGDFLIFGCETRGLPENLLEQVYDRCIRIPMRPEARSLNLSNSVAIVLYEALRQTDFPGLSSQGHLTGRDEESAPWLDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9P1</accession>
    <name>R7I9P1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48609">
        <property type="protein sequence ID" value="CDE48609"/>
        <property type="gene ID" value="BN770_01749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="8">
        <location>
            <begin position="22"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="821" mass="91985" checksum="71C0414B0AAB8C98" modified="2013-07-24" version="1">MAKKTSDNRPIPKDDPSRILQTTVEDVMHQSMIPYAEHVILERALPRVEDGLKPVQRRILYTMMELGTTPDKPHRKCARIVGDCLGKYHPHGDSSVYDALVRMAQDFSMRGPMVDGHGNFGSIDGDSAAAMRYTEARMTPLALEMLRDIEKDTVPFRLNFDDTLKEPDMLPARFPNLLVNGASGIAVGLATNIPPHNLGESIRAAIAVMENPDIPLDELMKIIPGPDFPTGGVLVKNEEIRRGYETGRSKLSLRARVHVEDGVNGRKLLVITEIPYMVNKAAMLEKILKLSEEKKGQLQNIYDIRDESDREGMRAVIELKKDADPDKVLKVLYKYSDLQVTFGVNMVAIAEGKPVQMGLKTMLGHFIRHQKNVITRRTEYDLKQAKARAHILQGLMIAVDNLDEVIALIRSSKNPKEAKARLMERFSLSDAQAQAILDMRLQRLTNLEIIALRKEYEDILKLIDRLEGILHSEKKLLAVIRKELQEIAEEFADERRTTIEKADESPLEVEEETAAPEEVIVAFTGAGQLKRMNPALYKKTPLPTRAEDDKEFADFLFMAKTDETLLIFTDHGNCYPLPVASLNEVKPKDRGQLLSGVLAGLEDDEKALWMTCIRMADVGHLPDILFITRQGMVKRTAAADYDVRSKKFAAVNVKDGDRLLTVLPAASRDDLLLFTRSGLCIRFSLDSVPVQGRVAAGVRCMQVEDGDEVIWCGQLQDSDQIVLLTDRGYAKRLLSVDFEKQNRNGKGVKSFYFNKNGSNGKQLAGVVRLEKDDHLIRVQQAKSPATLVERDNVRLQGKQDRGMPLVIAVMDDVVTGAELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9V2</accession>
    <name>R7I9V2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000101">
        <property type="protein sequence ID" value="CDE48380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48380">
        <property type="protein sequence ID" value="CDE48380"/>
        <property type="gene ID" value="BN770_00140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="145"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="328" mass="37558" checksum="E4D31041C6488261" modified="2013-07-24" version="1">MSENNYRITDRPLFLLRYIVQHTNDDHKVSLADLIAYCEQHGHSGSRHAISNDIDILNRYGFDIICTKEGNKNFYSYGSRLLETAELRMLIDAVAAAPFLTARHTACLTQKLASIAGLYDAEQLCATVSASNQSKSVNGRIFLSIDIIHQAIAASKKISFQYAAYNGQHNREPRFSEEIVFSPYSTIWRTDWYYVVGWSDSESAIRAYRLDKMQIPCFVDAEAVKKPLDFHPADYVESYLSHACVYQKTAVTLECENSMMNHVIDQFGEHFPYRQIDNTHFQATIPVKLTRSFWGWIFEHAGSIRIAAPESVQTQYRNMLRRALESIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAK0</accession>
    <name>R7IAK0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000111">
        <property type="protein sequence ID" value="CDE48521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48521">
        <property type="protein sequence ID" value="CDE48521"/>
        <property type="gene ID" value="BN770_01718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="133" mass="15395" checksum="7C936EAE4BB41E87" modified="2013-07-24" version="1">MFIYIFNQFFRGLPKEIEEAAFVDGAGTWYTYFRIMLVNAMPAVITVTVFSLVWQYTDSFYSQLFRIPTDMLLAKRLSTLQNNISANLKIMNVRIQRLYVDAGVVLTILPLLILYLLLQRRFIEGVERSGIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAM0</accession>
    <name>R7IAM0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartokinase</fullName>
            <ecNumber evidence="12">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BN770_01876</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="12"/>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48944">
        <property type="protein sequence ID" value="CDE48944"/>
        <property type="gene ID" value="BN770_01876"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="378"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE48944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="438" mass="47638" checksum="A231392C5CF8D7F1" modified="2013-07-24" version="1">MKKIVTKFGGSSLADAGQFRKVKDILLLDEARQYVIPSAPGRRFKDDDKVTDLLYRCHKQKSAGEDYQDTFDLIAARYMDIAEELGLHVDLGAALDEVNEKIDAGANADYCASRGEYLNGLLLADFMGWRFMDAAEAVKFTADGAFDAETTNTLMAEKLSDGVPTVVPGFYGSYPDGTIKTFSRGGSDITGAIVARAVEASVYENWTDVSGFLMADPRIVPHPREISSITYKELRELSYMGASVLHEDAMFPVHKAGIPTNIRNTNDPSHPGTIISLNAPHDDLHPTITGIAGRKGFSVISIEKAMMNSELGFGRKVLQAFEENGVSFEHLPTGIDTLCVVVSGEVFAPKRDIILSRIVHETNPDTITVYDNMSIIATVGRGMVHNCGTAARLFAAMSKAGINVRMIDQGSSELSIIVGVNDADYESTIQAIYNAFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAN2</accession>
    <name>R7IAN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000097">
        <property type="protein sequence ID" value="CDE48338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48338">
        <property type="protein sequence ID" value="CDE48338"/>
        <property type="gene ID" value="BN770_01660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="128" mass="13951" checksum="BA2036E7048301DB" modified="2013-07-24" version="1">MTLLRALVSRFSALLGDVYYEGTVPPDAPYPYAVISAKIPAAFGGTGEITLCCYEHGGDSHTRIAEKMARVMRFSGSLVHYGGGLALLQSPKCAIGHEKGGITVLRMTMAFTHYPNQCYSLRKEEFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAR6</accession>
    <name>R7IAR6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamyl aminopeptidase M42 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48586">
        <property type="protein sequence ID" value="CDE48586"/>
        <property type="gene ID" value="BN770_01729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="345" mass="37367" checksum="6F0811CEBFEF2506" modified="2013-07-24" version="1">MQEKYAQLALENTVRLLGIDSPSGYTEVAAKYVQAQFAQMGYDAKITRKGGVLIDLGGEDTQDALLLEAHTDTLGGMVAQIKGNGRLRITNVGGMNANNAEAENVRVITKFSGTIDGTVQLCDASVHVNGNYSTTPRTFDTVEVVLDEDVRSAEDVRKLGIDVGDFVCFDPRSRITESGYIKSRFLDDKLSVGILQAFAQYLKDENLTPKRRVYVHVTVYEEVGHGGSASVPDGVTEAISVDMGCVGEGVQCTERQVSICAKDSGGPYSYDVVRKLIAAAKREGADYAVDVYPHYGSDVEATLRAGYDIRHGLIGAGVYASHGYERSHRDGALNTLKVIEGYLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAU0</accession>
    <name>R7IAU0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein BN770_01751</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48611">
        <property type="protein sequence ID" value="CDE48611"/>
        <property type="gene ID" value="BN770_01751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12337" checksum="06A2FEC9A2D606A5" modified="2013-07-24" version="1">MARQNFGFGGGANMQQLMRQAQKMQQAMTDAQEKLDAQEYEAQSGGGVVSVKVNGKRELLSLTIDPKVVDPDDVEMLQDLVMAAVNEALRKGEANREETMNKMAPGMGGMGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBI9</accession>
    <name>R7IBI9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48673">
        <property type="protein sequence ID" value="CDE48673"/>
        <property type="gene ID" value="BN770_01782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="679" mass="76231" checksum="88A03B2F01EE96C7" modified="2013-07-24" version="1">MTAFLGVLYLLVFLAAGCTCVRFLLPRKSLLTRVWLGVSLGLLLMMWLPALIAFAADFTWTAHLLALIPLAGLTAGCFFLRDPSPVKKWDAREKQLAGQMLMVVLPLTLLSGYLQYTHCLRVGNDGGWWVGQSTYGDLPMHMSFITSLKNAAFPPDYALFPGQRLSYPFLTDSLSTSLYLMGFSLEWAIVVPGTLMMALCFTGVMVLAREMTAGKKTIILATLLFFLNGGLGFLYNFDLAGGTVSNPFSTVIERIREILDGYYATPTNQPTPYNLRWSNVIADLMVPQRTLLGGWCMALPCFYLLFTSFAPEKRPAFAQRIRQTGLLAVWAGALPLIHTHSFLALGLCSLGMMVYDLIHDKERWTQLQWYLSYGVIAVVLSAPQLICFTFEQVFQGTGSGNSFLQIWLNWVNGYESNGEFAFRDLYFWFYLKNIGLPFLMLILALFERNPKHRRLFAGALPIILAVELVRFQPNIYDNNKLMYLAWLLCCMIVADWCRDVWHRLKGMRGRGALAVVTAIAVFLSAGLTLWRECVSNYQAFSASAVEAGEFARDNTPEHSTYMTGTQHLNPIASIAGQNIVCGPDLWLYYHGLDTSERKMDIAAFYTDLEENLDLLEKYDVDYIYVSSYERSSYAVDTDTLDRLFTRVFSNWEATIYAVHPSSETEDMGNGASAALRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBJ1</accession>
    <name>R7IBJ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_01407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47872">
        <property type="protein sequence ID" value="CDE47872"/>
        <property type="gene ID" value="BN770_01407"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036692">
        <property type="entry name" value="SDH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="221" mass="23829" checksum="FD1D3BB940505C85" modified="2013-07-24" version="1">MDLFDLIGPVMIGPSSSHTAGAARIGLTAYSLLGERVVKADVGLHGSFAKTYRGHGTDRAIVGGLLGMHVDDPRLRDSLEIARQQGMDVRFEQVNLRGAHPNTVRLHVTGEHGTALTLEAASVGGGNIEIHRINGLSVNFTGKADTMIIHHIDMPGAIAAVTSTLARHRVNIANMQVYRRKLGGDAMMVLELDGAPSQADLDIIRQIPDIRSCTFLKRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBN7</accession>
    <name>R7IBN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LICD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49299">
        <property type="protein sequence ID" value="CDE49299"/>
        <property type="gene ID" value="BN770_01964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="250" mass="29571" checksum="9CD9FB903ED5D6E1" modified="2013-07-24" version="1">MQQEEKKLSLDEIHAELLEQLRDITAVCKKHNISYNMMCGSLLGAVRHKGFIPWDDDVDLLMTREEFQKFREIYPKECDKRFELTYLDTWTPRVMNRDPEKAAAFTDFFILDPVPPEGFQRKWWFFKLHTLQGMLKKNVDWSRFNWKNKILIFGTHLLGLPFSVKTKTRWYEQVSRQEKTGNDLCMSNGAFELMMHIWHPDQFAEKIVVPFEGIDVLIPAKWDEVLTILFGADYMTPPPEAERVAKHLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBR8</accession>
    <name>R7IBR8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49334">
        <property type="protein sequence ID" value="CDE49334"/>
        <property type="gene ID" value="BN770_01981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="118" mass="13518" checksum="7D9F75A65DA084AC" modified="2013-07-24" version="1">MTDTPNTPELNPQDVQDEDDLDVVVMTDEDGTEYLYDIAARMEHGENEYVVLVPQDENDDEVVILRSEIVDDETEEFVPEEDDSITDAIFEEFKQMFADDYNFADGDEGDDSMFTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC00</accession>
    <name>R7IC00_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48032">
        <property type="protein sequence ID" value="CDE48032"/>
        <property type="gene ID" value="BN770_01508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="249" mass="28101" checksum="AC683280033AB235" modified="2013-07-24" version="1">MDLTHVIAERENKKIYRDGAKAIKVFAEGYSKADILNEALNTARVEETGLPIPKLLAVDTVNGQWAITTEFVEGDTLAALMAAHPEKEDEYLNLFVDIQMKVHACTCPMLNSLTEKMQRKISATDLDATTRYELHTRLASMHVHKKVCHGDFNPSNIILKPDGQWYILDWSHATQGNASADVARTYLLFVLEGKEALAEKYLSLFCKKSDTAKQYVQQWIPIVAASQSLKGKPEERDLLIRWASVCEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC79</accession>
    <name>R7IC79_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">BN770_00148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000135">
        <property type="protein sequence ID" value="CDE49101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49101">
        <property type="protein sequence ID" value="CDE49101"/>
        <property type="gene ID" value="BN770_00148"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="50"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="426" mass="46270" checksum="5D82F9AC23719852" modified="2013-07-24" version="1">MRVLLKDGSVLEQGKWKQTDVAIENGVIVARGEQLSFPAEKVFDCRGFALFPGFVDVHVHLREPGFSYKETIATGSAACAHGGYTTVCAMPNLNPAPDNSEHLAVEEALIQGEAVIDVRPYASITMGQKGEGELTDMAALSGRVCGFSDDGRGVKTAETMREAMKKCKAADSIIAAHCEDMSWIPAGGAIHDGAFAKEHGIPGIPSESEWKPIERDIALCRETGCRYHVCHVSTKESVALIRQAKAEGINITCETGPHYLLLCQDDLQDLGRFKMNPPLRNKDDQEALLAGLLDGTIDMIATDHAPHSAEEKAKGLRGSAMGVVGIETAFPLLYTYLVETGKMPLEMLIDRMADAPRRRFRIDGGMQVGDKAAVTVFDLHAQEKIDPNTFLSKGRATPFEGWEVHAACRLTVCGDKIAYNALSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICP0</accession>
    <name>R7ICP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48252">
        <property type="protein sequence ID" value="CDE48252"/>
        <property type="gene ID" value="BN770_01599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="109" mass="11678" checksum="6C4E9ADAA1C87850" modified="2013-07-24" version="1">MFRAVESTAAKGYGGKKDYDNPNFRMQMASSAGAPIRSMIISGGMKGGVLPGMLEMANGHFFRGIWKMLTGGGENAKSIRLHDEPCVPLYGAGQAGAPHDYAAERKRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDA0</accession>
    <name>R7IDA0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bifunctional enzyme IspD/IspF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
                <ecNumber evidence="13">2.7.7.60</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="13">MEP cytidylyltransferase</fullName>
                <shortName evidence="13">MCT</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
                <shortName evidence="13">MECDP-synthase</shortName>
                <shortName evidence="13">MECPP-synthase</shortName>
                <shortName evidence="13">MECPS</shortName>
                <ecNumber evidence="13">4.6.1.12</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ispDF</name>
        <name evidence="15" type="ORF">BN770_02010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the IspF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="13"/>
    <dbReference type="EC" id="4.6.1.12" evidence="13"/>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49421">
        <property type="protein sequence ID" value="CDE49421"/>
        <property type="gene ID" value="BN770_02010"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01520">
        <property type="entry name" value="IspDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026596">
        <property type="entry name" value="IspD/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YgbB" evidence="14">
        <location>
            <begin position="228"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" evidence="13">
        <location>
            <begin position="228"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="13">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="13">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="13">
        <location>
            <begin position="282"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="13">
        <location>
            <begin position="287"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="13">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="13">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="13">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE49421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="384" mass="41029" checksum="6449D389932CC708" modified="2013-07-24" version="1">MWGAIILGGGSGQRMGAKCNKVLLPIAGKSMIVRSVEAFVPLVEQVVVVSREEDMPVMASELAQNGLDVPVVSGGATRQESVWRGLQALSGQCDGVLVHDGARCLVTADVIQRCMASVEECGTGVAAVPVTDTIKTVSDANIALDTPNRTALRAVQTPQGFKTDLLRQAHEQAQRDGFLGTDDASLVERMGVPVQLTEGSRRNIKLTTPEDLLMTEAFFAEQALPALRVGQGYDVHRLVEGRPLILCGVTIPHTLGLLGHSDADVALHALMDAMLGAMALGDIGKHFPDTDEAYRGISSMLLLRHVVALLKAHHARVTNCDVTIVAQKPKLLPYIPQMRQNVADALELPLARVNIKATTTEKLGFEGEEKGISAQAVCMVQENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDE0</accession>
    <name>R7IDE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49655">
        <property type="protein sequence ID" value="CDE49655"/>
        <property type="gene ID" value="BN770_02078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447859" evidence="2">
        <location>
            <begin position="26"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="141"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="785" mass="86534" checksum="A9C441253368CAE2" modified="2013-07-24" version="1">MKKKLSLLVALTMMLGSMAGLAEEAKQGPTEAELLAKPCEFSLIEANGEQPRLTYIEGVTPILEVDGYKFKDMNKNGKLDPYEDWRLDTETRVNDLISQMTPEEEAGLLFCVSANLETARSLIPDFNLTCMLFNLNGAPDNVVSTLNNLQAAAEKERLGVPMIFTSDREFNAWGGYIDKAHIAYGTANDPELAYKLSNIYGKAMVAVGIHVTFEPYANEIGAQYGENPEHIANIVYQEVKGMEDAGFASCVKHWIGRGGDSNFGNARSVAQNFDNWMVGWKAALAGGNEWVMTNCGGTGITNTTDVKWDSVTMSYLRDTLGFDGIVVTDWWALGMRQQVSGVTNEGVELSEQTGRWLYNEALKNGTDMFGAGGIKHGEEISENTMWNWPDCIVNGLKEGDVEKQWVDRSAARILKFKFEKGLFENPYRVMDEALAVVASPEWIANRTAIHTNEDLRAARTAEEVELAEKLQAKSAVLVKNDNGLLPLAKGTKVYIESSSADTLDHYKTYLNNFGTVVENLEDADVAIGYFNSVDDATELFVEDAQDAGKPIILTMVNKVTEYELKNANAVMYIPYSQKPDHGSGEAGFIYGTEPWIYADLIFGERQPEGIIQKEQARNSWSDAAQWKDLAGDQGASNYVRLLVQALMEDDPNHASPNNFGDPLVVYNYSMRYGQKGDFQYSCLILPSVYAEQETTNSRGQTVKSVVGTVSAKAGEEFMVYCLLRNNGADDLTYVQVKDGDEVVAEKLYTVCGGSWRVVEIPVTIATPGEHTITVGTQSGTITIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDJ4</accession>
    <name>R7IDJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48647">
        <property type="protein sequence ID" value="CDE48647"/>
        <property type="gene ID" value="BN770_01768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447862" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="54" mass="5942" checksum="D7AAB70874C3498F" modified="2013-07-24" version="1">MRKHLSEILLTLLTVALLVGFAFAVPHPAITDDALEAYMNDGAAADDDYDFLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDL2</accession>
    <name>R7IDL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49393">
        <property type="protein sequence ID" value="CDE49393"/>
        <property type="gene ID" value="BN770_01996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="107" mass="12062" checksum="00A3C12DD88A8293" modified="2013-07-24" version="1">MSLEIMKGIQQAEAQADEIRQTAQREARDVVKAVEAAIAQQERAAAIENRAQYAQAMEDKKQEVEHQLTAQRAKAGKQREALCQQARKHLPEAVSAIYERVLQHGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDL8</accession>
    <name>R7IDL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recG</name>
        <name evidence="11" type="ORF">BN770_02098</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 8"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49715">
        <property type="protein sequence ID" value="CDE49715"/>
        <property type="gene ID" value="BN770_02098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="258"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="449"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="668" mass="73762" checksum="0BED263DF147A37D" modified="2013-07-24" version="1">MELSAIKGIGPTRLESLRAVGVCSLRDLLYFLPQRYEDRTHPIPCADANGGEVLVMGVVQDAPKLSRFNGLTRVTAYLWDDSGKLPLVWYNQPWMMQNLPVGQTIMLFGRMGQSRGKPVLQNAQRVTEPCILPVYRAVKGIPAKSFREMMQQALEQVDDCCPETLPNDLRIRHQLCELNFAIRQAHFPLNVENLRLARRRLAFEQMLMYQAALGLLRGHKADGTALPIPPDAPEKFWQTLPFPPTGAQKRVLEEIAADLRCDRAMSRLVQGDVGCGKTALAFGAIAMTCACGYQAAMMAPTEILACQHYESAKAMLEPLGIHCGLLIGSMRPKAKREAQEACANGEYQAVFGTHALISEKVAYQKLGLVVTDEQHRFGVMQRSTLQQKGADGTKAPHVLVMSATPIPRTLALILYGDLDVSIVDELPPGRTPVKTRVVPEEKRAGMYGFLRQEVLKGHQAYVVCPLVEDSEMMEDVRSAQATFDALKNGELSGLRVGLTWGAQPADEKAQVLSEFSAGNLDVLVSTTVIEVGVNVPNASVMVIENAERFGLSQLHQLRGRVGRGSAESWCFLLAAENERLRILTQTNDGFIVAQKDLELRGPGDLMGTRQSGEMMADFLLDGDVKLLDEAAKCMKRLRENPKLAAERQQVEAEALRNYRDKLADIAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE87</accession>
    <name>R7IE87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type transport system permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49638">
        <property type="protein sequence ID" value="CDE49638"/>
        <property type="gene ID" value="BN770_02066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035277">
        <property type="entry name" value="MalF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="34583" checksum="C2A514B4ED5C2EF9" modified="2013-07-24" version="1">MVESKHQWKAWLYLAPAIVLLLVFTVWPIINTVRLAFLNDYNSLSEVGGATFTVGVKNFQTVIGDSGFKTALKNTMLLCLFTVPISTILALLIAVALNSIKPLQKVLQTIFFLPYVTNSIAIGMVFAAMFNIIGMPHMERLIQTKGIVNNVIELFGGHYVNWINQGSEYWANMFVMIVYIVWNALPFKILVLLGGLQGINKQYYDAAKVDSTPRWRVFTKITVPLLSPMIAYVVITGFIGGFKEYTSIVGIFGETMGPAGDAGRMNTIVGMIYDALPKSNYGVASAAALILFAIIFVVTMINMQVSKKRVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEC6</accession>
    <name>R7IEC6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_02120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49756">
        <property type="protein sequence ID" value="CDE49756"/>
        <property type="gene ID" value="BN770_02120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="438" mass="47912" checksum="8863C133ED29C674" modified="2013-07-24" version="1">MKLDRKKMLLISFMLFSLFFGAGNLIFPPFLGQNAGSSTVSAMLGFLATAVILPVLGVIVVARFDGLEQLAQHAGKKFSLIFTVLIYLSIGPGLGIPRAASVPFEMAVAPYLPQDANIRVWMVVYSLVFFLVALWLCMTPGKLVSRIGNFLTPSLLILLVFLFISFLFRGQVNIAAPQTEYSAAPFLKGFSEGYQTMDTIAALNFGLVIATTLGSFGLTQRKDVLRHTVKAGLFAGLILSAVYMMLSYMGMCSSGVYDIQENGAWTLRCIVFQLFGEPGAYLLAAIFTLACLTTCVGLINSISQYFSHLFSRISYRKWVFLIIGFSFLICDLGLTVILSISIPILNAIYPIAIVLILLGITHRVWAKNRYVYPIVVAGTGVVSVLYALDTLHLPLGILGTLCHALPLYEHGFGWVSVALAMLLIALPMPRIFAKQKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEX0</accession>
    <name>R7IEX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterial stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAPAB/TerDEXZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49996">
        <property type="protein sequence ID" value="CDE49996"/>
        <property type="gene ID" value="BN770_02225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="207" mass="22201" checksum="1685A63EFF891F1F" modified="2013-07-24" version="1">MAVNLKKGQKVDLTKGNPGLSKIMVGLGWDVNRYDGGHDFDLDASAFLLGANGKVANDSNFVFYSNPADPSGAVRYGGDNRTGAGEGDDETIFVDLATVPANVEKIDFTVTIYDAAERRQNFGQVSNAYVRVVDESTGMELIRYDLEEDFSIETANVVAEIYPHKGISPLKRRLLLRKSTATTVNGSSMPSAAASRADSKHSASTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF65</accession>
    <name>R7IF65_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">BN770_02276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50101">
        <property type="protein sequence ID" value="CDE50101"/>
        <property type="gene ID" value="BN770_02276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18722" checksum="6CA82A4F72782464" modified="2013-07-24" version="1">MAIRKIVKIGDDCLRQECRKQEKFDLRLKILLRDMADTMYKAEGVGLAAPQVGVLRRVVVIDVGDQGDGLLELINPVITMREGEQCGREGCLSLPGRQAVVTRPRKVTVQYQNRDGVHCEKTVEGLFARAVCHELDHLDGKLYIDVMDRELTPEEIEGHIPEDDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFI8</accession>
    <name>R7IFI8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49327">
        <property type="protein sequence ID" value="CDE49327"/>
        <property type="gene ID" value="BN770_01974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="232" mass="25303" checksum="3C8563539CB7726D" modified="2013-07-24" version="1">MLNNSQGSQGNNDLQTAQNAIAILIDQISKARGVGRTIVIDKNWLNNQLSALQNSLPAAVHQAQAVLKEKETTLSRAQQEAEMQRQTAADDAQRLKAQAEKEAAAARAEGEKARADAQKDADAAKQEAERIRAGAASQANADARAIIDKANNEARNIIYKAQQDANRLVQADAVRQQAEKEAETLRSQASEDIAKRQADCQQYIAGQLANLDSYMTQMLQNVRNARSQVRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFK7</accession>
    <name>R7IFK7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein CUT1 family (TC 3.A.1.1.-)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50395">
        <property type="protein sequence ID" value="CDE50395"/>
        <property type="gene ID" value="BN770_02361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435874" evidence="1">
        <location>
            <begin position="24"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="408" mass="43116" checksum="33316036FE52D9E3" modified="2013-07-24" version="1">MKKLLAMVLAAVMVLSLCSCATAEETVALRVWVGDNADLPWINSVIENFKAAHPEKTYDISVDIQAEGDCSKRVLNDTEAAADVFTFADDQFNSLMNAEALQQVMVDADEIIAANGGANAGAVQASTGADGNLYAYPATADNGYFMFYNKEYFTAEDVQTLDGMLAKAAAAGKYVGFPMSDAWYLYSFFQGAGLDMYVTEDGVTNTCNWNATDTEITGVQVVEALLAITSNPGFLDANSDPFVAGVKDGSIIAGVSGTWNAKVAQEAWGENYAACKLPTYTVAGKQVQMASFAGFKLVGVNPYSQNVGDAMLFAEFMTNEENQISRFEIRGQGPSNVNAAASEKVQAAPAIAALAAQSAFSTVQRVGNKYWEPAAALGKILVNGNPDGIELQTLLDNAVAGITAAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFT7</accession>
    <name>R7IFT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49442">
        <property type="protein sequence ID" value="CDE49442"/>
        <property type="gene ID" value="BN770_02021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="94" mass="11404" checksum="FA38450B10F35125" modified="2013-07-24" version="1">MQWGLNVPQQPRQLDKRFSDLKLCQREQIAKWLREETNDYYTRHQRYPIGREAEDVVDNAYVQIVKAGIWIPYGEVYQYYLSRKARMMKHPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG19</accession>
    <name>R7IG19_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rplX</name>
        <name evidence="3" type="ORF">BN770_02443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50575">
        <property type="protein sequence ID" value="CDE50575"/>
        <property type="gene ID" value="BN770_02443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="111" mass="12053" checksum="87AEA7517CA042A1" modified="2013-07-24" version="1">MHVRKNDQVMVITGKDKNTKGKITVAFPKTGKVIVEGVNMVTRHQKARNAMQPGGIVKKEAAIDASNVMLICPKCGKPTRVSHKVNVAVDANGKKNRTMVRVCKKCGADID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGG1</accession>
    <name>R7IGG1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ANTAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50408">
        <property type="protein sequence ID" value="CDE50408"/>
        <property type="gene ID" value="BN770_02373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="1">
        <location>
            <begin position="124"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="190" mass="21080" checksum="887F9A6B0F80EA0F" modified="2013-07-24" version="1">MQEQILLAGSTEKSRMLLQTLLPPGTNPPPRMCMSGAETRRALGEDDWPLLVINTPLSDESGIDLAIDAASHTATSVLMLVKAELADQVQAQLENYGVFVVAKPVARPLFDQAIRYAAVLRNRLMTVCAEKAKLEKKLADVRVVDRAKCLLIQYRGLTEEQAHRAIEKQAMDTRQTRVAVAQTVIDHYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGJ6</accession>
    <name>R7IGJ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000177">
        <property type="protein sequence ID" value="CDE50725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50725">
        <property type="protein sequence ID" value="CDE50725"/>
        <property type="gene ID" value="BN770_00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="265" mass="29996" checksum="683B8FC1C50DBFE4" modified="2013-07-24" version="1">MQVTQPNEFYKGLPKEDVFFVKDDQNNPVGEGFLIYQYQPTIFPSRPVNIYFSMTSKPEGEYWLLGSLAARARQLRNQAPGAAARLYTAVDVQDERQLAFYEHNGFKMDYTEDLVRLNDPDEVPQLFNCSCITLPLNTVQEQMDLVSRMRGAGFSYFDHGFLLQQMNRQNFAALGILYGSNLVGACVAAGQYTSAEVMGLYIVPEFQRKGLGTRLLQQTKQALASTGVTDLTMRVMSDSEPQVRLVQRFRAELVEHTSVFPSMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGL4</accession>
    <name>R7IGL4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">BN770_02455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50606">
        <property type="protein sequence ID" value="CDE50606"/>
        <property type="gene ID" value="BN770_02455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE50606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="102" mass="11658" checksum="72B2685DFB0BBC99" modified="2013-07-24" version="1">MATQKIRIKLKSYEHTLIDQSAERIVETAKRTGARVSGPIPLPTEKEIVTILRATHKYKDSREQFERRTHKRLIDIMNASAKTVDAMSKLELPAGVEIEMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGS4</accession>
    <name>R7IGS4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51014">
        <property type="protein sequence ID" value="CDE51014"/>
        <property type="gene ID" value="BN770_00262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030828">
        <property type="entry name" value="HTH_TypR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18024">
        <property type="entry name" value="HTH_50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="117"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="414" mass="47179" checksum="DA2824AF565B468A" modified="2013-07-24" version="1">MKLNPDGVIEIANTVAENAFHCTQAQLVGKRFTELPGLTLTSAVFESLKERKNLYSHVVMIQKERYLLNIACIDVSGQNFGTILSLYAFGSVDDMQESIRKDHVQQGDAATRKFGKFISHAPKMRLALENAAMYAQYELPLLICGEPGTEKTRLAECIHNESLRRDKQFIQADVSTLPIANQTELLFGRATSNGLVYNAHKGTLYLRHVDLLTPESQHQLLNVIRYEQYYAPGQSKPIWASIRVICSTNRDLLAMAKAGEFLLPLADKLNDYRIDLPPLRECQQDFAQLVEENIVFARVHTRKQATFTPDALKLLMSYSWPSNQREMSIFFEKAFLLTRTNRMDADFVQQLLYPERTGSAPQQQVLVISSDEERELRCALSEHPSDRDAVLKQLGISRATLYRRMKKYGLQQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGT2</accession>
    <name>R7IGT2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC_transp_aux domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50800">
        <property type="protein sequence ID" value="CDE50800"/>
        <property type="gene ID" value="BN770_00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435924" description="ABC_transp_aux domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="3">
        <location>
            <begin position="41"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="474" mass="50795" checksum="1FAD441B25F7815C" modified="2013-07-24" version="1">MKKKSMPYGVYHLLTCVLAVVMAVLAVLVSQRAEEKWYLKLDVSPSGVTNLSDYTLSRLHELDEDVLLYPVYTSGYDSTVRDLVTETLNKMSAECAHVRVETIDPVTQPQRIAALSGDAGSIENGTVFITNQDATRIIRLSPEEFLFSRTVLGEEYTIYCGEAQLIGAIGRACTDHPVGVYFLTGHGELTQEDCSLLALQLRSNGFEVHSGEIARIAPSATDILLLLAPRSDLTGDEAQTLAAFLDNGGRVLVACGADTPLSRLTQLQAVCSLYGLGFQSGWVVESAAESDRYVDAPEYLSPVVAADYEITGRILLPRTSALITPALRPGVTVTPLLTTSDRAVLHPDASGNALDSQTGDVSGQFLLGAMAKKSSGTALCLLASSDMLRDSASISGASVLDASDNLALLTDLVTDMADIDQTASLDAGVKRLPAQRITFDSESSRQRVTILALTLIPGVLLLTMAVVLLKRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGV4</accession>
    <name>R7IGV4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gatB</name>
        <name evidence="12" type="ORF">BN770_02140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49792">
        <property type="protein sequence ID" value="CDE49792"/>
        <property type="gene ID" value="BN770_02140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="331"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE49792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="477" mass="53031" checksum="BC13049A9C2144FC" modified="2013-07-24" version="1">MAWKMMDGYEMVIGLEVHVELKTKTKIFCACPTTFGAAPNTQCCPVCMGFPGTLPVLNRQVVHYAVLAGLATGCTIARYSKQDRKNYFYPDLPKAYQISQYDLPLCVGGHLMVETEAGEKRIGITRIHIEEDAGKLVHDPEKGTLIDCNRCGVPLIEIVSEPDIRTPQEAVAYLHKLKAVIEYTGVSDCRMQEGSLRCDVNLSIHKKDEPFGTRTEMKNLNSFTSVQRAIEEEYRRQVEAVKKGEAIVQETRRFDQTTGKTFSMRRKENANDYRYFPDPDLAPIVLSDEVIAGWRKELPQLPDVRKAAYMADYGLTAYAAEQLVSSKYLADYFETAAQSTAAVKMLANLMISEVFRLLDGEDAKIPLNPASLAKIADMTEQSLISVGTAKKTIDALWNTPEDPEEYVTRMGLMQISDEAVLTEYVRKAIDTHPEMVAGYRKGKLTLKNALMGVAMGLSGGKANPVVLQKLMDAALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGW8</accession>
    <name>R7IGW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000189">
        <property type="protein sequence ID" value="CDE51054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51054">
        <property type="protein sequence ID" value="CDE51054"/>
        <property type="gene ID" value="BN770_00282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="387" mass="45921" checksum="CB8C68157F712E32" modified="2013-07-24" version="1">MEKTSELLIYLMACSLQETKPEEALLANIDVEALLRLAKAHSVSAMVCMALEQTDAFRCAEESIRLKWLDSKNKVIRKNMLLDAERHRLEKEFAEHGIWYMPLKGSILKDWYPKFGMREMADNDILFDATRRQQVRDIFVNRGYSIESYNKSNHDAYEKQPIYNFEMHVALFHEDRSTLQKKYENVVDRLVQDEKLPFRYHFTPEDFYVFVVAHAYKHYSHGGTGIRTLADFYVMNRKLGKILDWEYVESELRSLGILDYERDSRKLSQKLFGNTKTVLRSELTEEENQMFAYYLGATTYGNLFNQTLHRMQEFQPDGEPLTTKTKGKYIISRMFPNMEWCKCYAPVVYKFPVLLPFYWVWRLIYKGITKRKKVTQEIKALKAVNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGY8</accession>
    <name>R7IGY8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplB</name>
        <name evidence="7" type="ORF">BN770_02451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50598">
        <property type="protein sequence ID" value="CDE50598"/>
        <property type="gene ID" value="BN770_02451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="276" mass="30066" checksum="EA83E67A7D4CE4BD" modified="2013-07-24" version="1">MAIRTYKPTSPARRFMSVLTYEEITKKSPEKSLVEYLKKNAGRNKQGKITVRHQGGGNKIKYRVIDFKRNKLEIPAKVAAIEYDPNRSAFIALLFYADGEKRYILAPLGLNVGDTVVSSENADIKPGNSLPLANIPVGTLIHNLELKPGRGGQLVRSAGMSAQLMAKENGFATVRLPSGEMRKLPLNAKATIGTVGNTDHENVRLGKAGRVRHMGVRPTVRGVVMNPNDHPHGGGEGKSPVGLPAPVTPWGKPALGLKTRKHKKYSNKMIVKRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH20</accession>
    <name>R7IH20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51104">
        <property type="protein sequence ID" value="CDE51104"/>
        <property type="gene ID" value="BN770_00030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="183" mass="20578" checksum="FA6EF951B24A7021" modified="2013-07-24" version="1">MDTDLQATDPSLQFMTSGVLDTTFYATYKKWLLYRTQDLNLYVAMVVMAIAVALISIFSRSWYVIPAGVVFIAVLYMMMMRNRTRMLNALSRALEEQYPEGMAEMSIAFGSDGLHQLNQTTGDLTVLPYDNLTDVIEGEDSMALLTRANALIPVFTSQLTESEKEHLLALLAEKAPKCKHHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHA4</accession>
    <name>R7IHA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type sugar transport system permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50816">
        <property type="protein sequence ID" value="CDE50816"/>
        <property type="gene ID" value="BN770_00215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="281" mass="31580" checksum="25E4DDAD36FE5F51" modified="2013-07-24" version="1">MTTVQSLKIRKRFRSVLYQIVAIAIGILLVTPILYALVISFMPGEDILTIPPRFIPSRWITDNYKMAWTLTTLPRFMLNSLILAGVSSVVRVITASMAAFALSFFEFRGRNVIFMLIMGTMMVPSDIVLVSNYHTVSRLGWINTYMGMMIVFFVSANNIFMMRQYYLTFSKDLKEASEVDGCGNIRFFCTILLPLSTPIITTIFISSFISTWNTYLWPMLVTNDNLMRTVQVGVTMLNFPEGSTYGPVMAASMIVLLPTLAVFVIFRRQIVGGIMGGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHN3</accession>
    <name>R7IHN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50813">
        <property type="protein sequence ID" value="CDE50813"/>
        <property type="gene ID" value="BN770_00212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="265" mass="29532" checksum="80DF332B635DC61F" modified="2013-07-24" version="1">MVKLVVSDLDGTLIDSSEQLTDTAREMARWLKDRNVLFTFATGRVQGMTERYAQDMQVSIPYVATNGAALIAPDGVLFRRKVPLKPLETMLRKADCMGMSIIYSEDGYEKVCRETPYILRQRAAFGRYNDVAPLTQADYDGKQMEKICVMDSDKTGDKIDYVEDFIRHLGDQYSYTRYGDKAVEIVHPGCTKAAGVAELAKRLNIPMSDVLAIGDDENDLQMLRLAGHTATVQNALAKVKPLVAYVSPYCHSAGVFDAVKHFIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHS3</accession>
    <name>R7IHS3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000211">
        <property type="protein sequence ID" value="CDE51319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51319">
        <property type="protein sequence ID" value="CDE51319"/>
        <property type="gene ID" value="BN770_00381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="307" mass="34168" checksum="8746393D5F816CA8" modified="2013-07-24" version="1">MKQECEIVRDLMPLVLDDVASDGSKHMVSAHVQTCAECAAYMNQLKADLPAGQKGAVDSHAAFDAAAQTLRKQKRRRTLRNILLGALIVCILGLANLYCFDWLMNETRPIPTSEYGIQLSKLADGRLVASFDYHESMTPLYVKQQQVTETAAAGSHAEILYLYAEKHIVPQTASTPMQNTGFTLDTNWQTANAEIRQGTPEEYQVLWRQEDEDAAIPAASPEMEAYYAWEAVLTQLWTQHSESADGKAGFPGVNGERYTLAIHHADALAACVPEWQPRVTPQYLLLDDETIQWILADVTEEVESNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHT5</accession>
    <name>R7IHT5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000213">
        <property type="protein sequence ID" value="CDE51334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51334">
        <property type="protein sequence ID" value="CDE51334"/>
        <property type="gene ID" value="BN770_00045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="78"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="479" mass="53717" checksum="6D1974389D1676E7" modified="2013-07-24" version="1">MVKSFMTNMPDQCGAFLAASRIIERHQGNIVRVSYNKAVDAHALFLDVEADDAVLSAIEGELNQAGFLKSVPHAKIILAQFDVPDHPGAVVPILEVLNRHHVNISYISSQSNDSGHASLKMGLYIEEPGVMDTLLRELSALCPVQILSYDSGEKKLDTTVFYLRFASEIRRLLRLTQEQTNEFTYYANLIMQELDERNEPPSKTFEYINRFARFVAEHNGAAYECRVTHVPLTEQVRAVVLEPPFGSNITVLEDVKTRALLVIDSGFRCCARYTLRQLRTIFPDFDERKREMLLTHSDSDHTGLAESMPVIWCSQRTADCFANESLGLPSPREASATGLPYYRLNKLITEYAVPPLNRLRILNTSHGDDEQPISPIGAFLFGDMRFNVLQGNGGHVPGETMLIDPVHRVAFTGDDYINPHNMTPPQKEFDRLAPYLARSVNVDSPRYHAILRAVLAMLDGKGYLIFPGHGGVVQRTEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHZ2</accession>
    <name>R7IHZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000218">
        <property type="protein sequence ID" value="CDE51404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51404">
        <property type="protein sequence ID" value="CDE51404"/>
        <property type="gene ID" value="BN770_00416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="262" mass="29324" checksum="D1BC1C5A7C9DA04E" modified="2013-07-24" version="1">MITILVKAADGTMIASAQSADDARLCIDRAYEDGDTVEILADEKHLCVQMDVTLLPGEVYLPNGRMRWRVPAGEHRLAYAPGAFEAKRHVITARPMTAEEINGRRDIACNPADLRGETDFFPHITANVETRNEACFCARNAINGLHCNNYHGEWPFGSWGIGAREDAWCCIDFGREVMVDAMALILRADFPHDAYWVSGHVVLSDGAEVAFDLQKTGERQIIPLGKHTVRWMRLERMQKSDDPSAFPALTEWEVYGCDKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7II97</accession>
    <name>R7II97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51519">
        <property type="protein sequence ID" value="CDE51519"/>
        <property type="gene ID" value="BN770_00474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34981">
        <property type="entry name" value="PTHR34981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9541" checksum="4563B49B08F6771C" modified="2013-07-24" version="1">MEKQKTTVRVAGKDYALVSTDSPEHLNRVAAYVDRQMTETMRSGRIPANTAAVLTALNLADDLMRAQDEVNRLRRELALLREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIK2</accession>
    <name>R7IIK2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000194">
        <property type="protein sequence ID" value="CDE51138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51138">
        <property type="protein sequence ID" value="CDE51138"/>
        <property type="gene ID" value="BN770_00298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="197" mass="22117" checksum="EFFAA4A161019366" modified="2013-07-24" version="1">METGLTREEALQALQTYNHEPFHLQHALTVEAVMGWFAKEEGFEAESDFWHMAGLLHDIDFEQWPEQHCVKCIELLQSAHATPELIHAVCCHGYGICTDVEPTLQMEKILFAADELTGLIGAAAKMRPSKSCTDMELSSLKKKFKDKKFAAGCSRDIIRAGAERLDWTLDELLEKTLHAMADTESTVAEELNLLLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIR2</accession>
    <name>R7IIR2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000200">
        <property type="protein sequence ID" value="CDE51188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51188">
        <property type="protein sequence ID" value="CDE51188"/>
        <property type="gene ID" value="BN770_00315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="328" mass="35864" checksum="BB29B55AB3F99975" modified="2013-07-24" version="1">MQRRRAGNTVRIQALVLFLERLDGVFCRTLVVAVRRTRHPAQFNQARLQRADACAGRTTLEIILSGEVWGRGGFRLGGCGLARSSGCGGCLDSVGAVQLCHRRFARDAVHQQIVAVLERTQRLLRRVAEIAVHAAGVVAQLLQAALERLDVSAGRAFFENGSRSRRGRCGRTRGGGDAAGRRGHHGDNAVGGNHARLRRRRSGVRAEIENGFNRRRGRRSGRSGALGRCDSNRIVNNTLIGQVARQVVRRHKAARQRHGQRQNAAQGSALENAVASSCSGMILHDDNSLPSHSGRAEQALSSRRICRKEAYGQSPIYIVHIYRAVCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIY1</accession>
    <name>R7IIY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51595">
        <property type="protein sequence ID" value="CDE51595"/>
        <property type="gene ID" value="BN770_00510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="164" mass="17313" checksum="53C0F1EF6AD93B74" modified="2013-07-24" version="1">MKKLNVQKLTLCGVMAALVFVMTYFPKIPVPVTGGYVHLGDGAIFLSVLLLGPLGIPAAAVGSMLSDLIGGYMVYVLPTFLIKGLVALVAWKLCRKDQPLLALLSFLLAEAVMVLGYFLLEWALYGVASAAAAIGPNVVQGIAGVLIGMLCLLITPRLERVAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIZ4</accession>
    <name>R7IIZ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="6" type="ORF">BN770_00449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000221">
        <property type="protein sequence ID" value="CDE51451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51451">
        <property type="protein sequence ID" value="CDE51451"/>
        <property type="gene ID" value="BN770_00449"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="252"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="499" mass="54578" checksum="B696BD48BA230F18" modified="2013-07-24" version="1">MRGKSLMVMGTASSVGKSVLCSAFLRIMKQDGYKVAPFKAQNMALNSFVTKDGLEMGRAQVTQAQAAGVEPDVRMNPVLLKPTSDRRSQVIVDGKAIGTMTAMEYHRYKPALRERIKATYDALESTVDCVVIEGAGSPAEINLRAGDIVNMSMAESADAPVVLVGDINLGGVFASLLGTVMLLTDEERARVKGVIINKFRGDVKILEPGLKMLEERIHIPVLGVVPWMDVGLEDEDSVTERFSRMMGQGDLDVAVVKLKHISNFTDFQSLALQPGVKVRYAQSAKEIENADLIVLPGTKNTIEDLIDLRNRGLDAAIIRHARKGGMAIGVCGGYQMLGRKLHDPDHVESRVPELAGLDLLDMEVTFAREKETAQASGVVDASGWLASSNGILVDGYEIHAGQNQFGERVLPWLRIGNRVDGVMNERGNVLGSYLHGLFDDGQLFAAIAAHIRKEKGIDTETQVPMTLDEYREREFDRIADIVRASVDMDAIYRIVRGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ11</accession>
    <name>R7IJ11_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000207">
        <property type="protein sequence ID" value="CDE51268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51268">
        <property type="protein sequence ID" value="CDE51268"/>
        <property type="gene ID" value="BN770_00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="256" mass="26736" checksum="B3C5A750C0186CC1" modified="2013-07-24" version="1">MVEKVLVCLLAGLGAGLGTGFAGMSAAAVISPMLITFLGMEPYEAVGIALASDVLASAASAWTYGKNKNLDIRNGLLMMAAVLAFTVVGSYVASLVPSRTMGSFSVLMTMLLGIKFIIRPVMTTREAMQNVSKKKRMVQSIVCGAFIGMICGFVGAGGGMMMLLILTSVMGYELKTAVGTSVFIMAFTALTGAVSHFTIGGLPDGWTLALCMAFTLLFAQIAAKIANKSKPETLNRVVGVVLVVLGVVILAVQYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ31</accession>
    <name>R7IJ31_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">BN770_00362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51293">
        <property type="protein sequence ID" value="CDE51293"/>
        <property type="gene ID" value="BN770_00362"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="446" mass="48738" checksum="ABBA09D3E6870473" modified="2013-07-24" version="1">MAMELKTTGVNGFVKPAELTNMETLLNAVNDELLTGKGAGSDFLGWLDLPVNYDKEEFARIQKAAKKIQGDSDVLVVIGIGGSYLGARAAIEFCKGQMYNGVREKGIPEIYFVGNNISSSYINDVVKIIGDRDFSVNIISKSGTTTEPAIAFRVFKKMLEEKYGAEGAKGRIYATTDKARGALKNLANVEGYESFVVPDDVGGRFSVLTAVGLLPIAAAGIDIAAMMKGAADARECCKEGTVDTNPAYKYAALRNILYRKGKNIEILVNYEPALMMTGEWFKQLFAESEGKDNKGIFPTAANFSTDLHSIGQFIQDGTRSLFETVVWVKNPRSELVIEAADEDIDGLNYLAGKSVQFVDSKAYQGTLLAHMDGGTPNIIIEIDEADAYHFGYLVYFFEKACGLSGYLLGVNPFDQPGVEAYKKNMFALLGKPGYEARRAELEERMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ63</accession>
    <name>R7IJ63_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S9 prolyl oligopeptidase active site domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51794">
        <property type="protein sequence ID" value="CDE51794"/>
        <property type="gene ID" value="BN770_00620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="451"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="661" mass="74521" checksum="24641EE4253A9DFE" modified="2013-07-24" version="1">MEQLQLDDFLMYNFLSQVQISPDGKKVAYVATTPDLAKNGYNANLYRIDAESGENACLTNSGRVKGFCWQGAETLLYTVPVEADDAFPDGQTVLYRQNAGSAAEEVCRGEGSLSLEGVLTDGSIVFSRVDNLTTEAALEGLAGHERLAARLAEKERNEVCTVFDEYPFWFNGKGVINKTRKTLYLWDGKELKRITPPRFRVMEVCVEGMKIAYAGCMVEPIEKELVGVYCYDAEKSKITCLLPEDEYYIEGMTFWGDSLAYCGTKMDRYSCAQCPDLLLLNLETGARTLLCDTDDEINVGNPVGSDCRMGGGYVMRADGEYLYFLTGVYDATHLWRTDRTGKMEKLLEKDGSIDCFDVQNGAVYCVAMYDMRLQELYRFADGKLTRLSSWNDDFFLTKPPVIPQPLQFINSDGVQIDGFVMTPTDHVPGKKTPVILDIHGGPHLTYGAVYYHEMQYWANHGYYVIYCNPRGGESRGNEFGYICGRFGTIDYDDIMAFCDEALKAYPDMDEKHMGVTGGSYGGFMTNWIIGHTNRFAAAASQRGIANFVSMEGTSDIGTLFAERQILATTHTNLDKMWKQSPLKYADRCTTPTLFIHSEEDYRCWMVEALQMYSTLIHHGVPTRLCLFHGENHELSRGGKPKGRIRRLQEITAWMDKYLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJA4</accession>
    <name>R7IJA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription termination factor Rho</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51844">
        <property type="protein sequence ID" value="CDE51844"/>
        <property type="gene ID" value="BN770_00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="138" mass="15036" checksum="14D745FC4EA24C25" modified="2013-07-24" version="1">MVNPVSLQKAKKLFGAARCLREGGSLTIFAVMNIETGSRVDDSIAEDLKGTANMELVLDTAAARAGIYPPVNLLLSGTKRAELIASKEQLDGIKLIHEMLGSLRAVDMIPQLLSMLEKTTNNEDLLVRIKDWAALMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJB7</accession>
    <name>R7IJB7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsular exopolysaccharide biosynthesis protein (Wzm)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51859">
        <property type="protein sequence ID" value="CDE51859"/>
        <property type="gene ID" value="BN770_00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="25"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="356" mass="41046" checksum="F77A94549609E7C1" modified="2013-07-24" version="1">MIDQEMQHCRKIVRFDPTISTANQGDFIIRNACEHVLHDCFPMQLSVVVPVRDRLSKVSMKHVGSADFAFVCGTNLLSSDMRRQRMWNIRLRDAVMMRCGDLHKRELLNFRLIREKFQRTHVILLGAGWYQYQDEPTGYTKRILKTLLDGQYLHAVRDEYTRQRLLKLGITNVLNTACPTMWGLTDDKCAQIPTHKAERVVTTLTDYRSSPEQDAQMLTMLQKHYREVYVWLQAVEDYACLRQMDARVTQNLHLIQPNLRDYTALLASGGIDYVGTRLHGGIHAMNMGCRSLILAVDNRASEIAKDTNLPVLPRGGNLDVLEERICSAWETQIDLPTTAIRQWKNQFRETDAEKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJH9</accession>
    <name>R7IJH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51641">
        <property type="protein sequence ID" value="CDE51641"/>
        <property type="gene ID" value="BN770_00543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043751">
        <property type="entry name" value="DUF5696"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18952">
        <property type="entry name" value="DUF5696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="858" mass="94750" checksum="74D9992248AB54EB" modified="2013-07-24" version="1">MKRRILVRIVLVLILLLALYPLTKFVILPLFDTSGELEGHDVPLYGYSEPDTPMVMENDALRFELDPATTHFTLTDKRTGHVWLSSPDNADSDPIALPVEKNKLNSTLSLTYAASTGMTTQFTSQEHSISNGVYEVLMQEDGSVRVNYSVGRVQRSFLMPTAIGDARMQQFMEKMTSKQKKDIKEYYREYNIDKLRKTDDKAALLAAYPDLAEEHVWVLRDGTKDHLKQRCESIFAEAGYTAEDLAYDNSRIVQAGSSIAKAVFNVSMVFRLDGSDLVVEVPLDDLAYDVDYPLTSLTLLPAFGAGGTADDGFLFVPDGSGAIIRFNNGRVSQRAYYANLYGWDWASIRTQVTNETRINFPVFGVSGDSGAFICILEDGASWAGIGADIAGRLTSYNTVNATYTIVHGDAYDVSERTNNAVYMFETAHPTGFIRQRYRFLPESGYMDMASSYRDYLTAKYPDFAAQTVDADAPLSIELIGAIDKVQQVAGVPTSVPIAMTTYAEAKDLLRELVTRNLAQNMSIRYAGWMNGGMNQQLLSSVRLIRQLGTQEELFSFAQNAAIAGVPLYLDGLTAFARDSGLLEGFISFRDAARFTTREEAEIPEYSPIWYGANDDRDTYYLVKPAIAMRSVNALADAAASYGAGVSFRDIGYMLSADYDSKNHTTREAVLHQQAEKLAELKASGRDVMIRQGNDYAAVQATLITDMDFDGGQYSIIDEYVPFYPLALHSRVSYTGASLNLADDAEEVLLRSAEVGAGLQYTLTAQSARVLQDSTYSEFYGADASLVLDDITAQVAQYRQTLSGIFNQEMTGHERVGNVTITTYANGTRVYVNFGYTDAAVDGITVPARSYAAQQEVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJJ7</accession>
    <name>R7IJJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted transcription factor homolog of eukaryotic MBF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51780">
        <property type="protein sequence ID" value="CDE51780"/>
        <property type="gene ID" value="BN770_00607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="334" mass="36318" checksum="76D329E5A9158AA6" modified="2013-07-24" version="1">MILADKIIDLRKKNGWSQEELAEKLGVSRQAVSKWESAQVIPDLGRVLAMADLFSVTTDYLLRDENEAPTPAAVEDGASESSVRRVSMEEASAFLALCRKQAPTRALAVSLCVLSPIPLLMILSRTGEGPAAGVGSIIGVVILLLLVVAAVVIFLRQGMESKEYEYLEQEDIETAYGVSGMVKEKQAAYRETCTRGIIVGVVLCILSAIPVLLGTLAADSVAAPERIMLPCVSLLLAMVAVAVYLFVRVGMVQGSFQRLLEEGDYTREGKRAARSPIVPIYWCLATAAYLAWSFITMAWDRTWIVWPVAGVLFAAVVGIIRMTHKEGRKEKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJP8</accession>
    <name>R7IJP8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50802">
        <property type="protein sequence ID" value="CDE50802"/>
        <property type="gene ID" value="BN770_00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448034" evidence="1">
        <location>
            <begin position="32"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="122"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="243"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="468" mass="50359" checksum="7511DB791B0C3D96" modified="2013-07-24" version="1">MRRGLRLLLMALVCALLGGVYVLLGSTVAPAEAPAPESTDAPGYFMLYEDSVAALKSITVQAKGSQRYTAVSDMAFDQNGNLLGVYNALSQPFLVSGQEDFTFSTAAWQMLLLTAQHIPATATYPALDRDACGLTDPDAVITLTRKDGTTRVLRIGRLTSDGASCYVSLDGDTNVYLVPYDFHETMVQPLNALHTLPGAIDESASAAVQIALTGTDDGQLIFTKSSGKLMAWSSTSPITHAGSTERIEAFITGLCAVSADEYVTTVADAAGLAVYGLDAPRRLIAAFQDGTIRDIHLGSDAGDGMVYARMDRTGDIYRIRRTQLTFAENAGLNTLLDRFVSPVVVATLSQVRVTTADGETTLRIEYENGDDNIGQRWFWDENAVTRDEFTDAYLSIIALQFDQTAPQEAAGTSLLADVTFTLRDGSTSTVRYEACDAFYALATTDGGGRFLVRLTDVENMLTVLKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJQ3</accession>
    <name>R7IJQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000228">
        <property type="protein sequence ID" value="CDE51548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51548">
        <property type="protein sequence ID" value="CDE51548"/>
        <property type="gene ID" value="BN770_00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="160" mass="17505" checksum="29B0C06259606356" modified="2013-07-24" version="1">MPDLEKFVKNVMYGGIGAAASLVEKGGDLARSLVEKGQETVRNSQDTADDIKRRLQEFCDGLMNRGEIDISKLTPEQRAELRHQLEEMDYQEIWGKESPEAADAPTTEAPETPEAPEAPVDPEPVNEPEAPKETEPAEADKPELSDDAIPVGGEPHDDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJR3</accession>
    <name>R7IJR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000229">
        <property type="protein sequence ID" value="CDE51558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51558">
        <property type="protein sequence ID" value="CDE51558"/>
        <property type="gene ID" value="BN770_00493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448354" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="192" mass="20668" checksum="C38F550E550BC40E" modified="2013-07-24" version="1">MKKLLSIALALCLLLSVALADVTLTKVYKTEDLVSNTFHNGFVTAIGMTGENTVVLKDDGTYEYTKRLMQTAEDGTVTADIVYTFTGTYTQDGDTVVLMFPTSGTASENWGSLAGSYFQNTENAAFADSDYAAGVVQCKEAESHLIADLFEGPYLLDNLTTSDAAFDAEECTVTITVSGDTFDYVITNSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJX1</accession>
    <name>R7IJX1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase YwbO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000183">
        <property type="protein sequence ID" value="CDE50897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50897">
        <property type="protein sequence ID" value="CDE50897"/>
        <property type="gene ID" value="BN770_00242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24703" checksum="5CAD48B8AC763E4E" modified="2013-07-24" version="1">MLTIDFLTDYVCPFCLVTKENLRAALKTLHQEAEIIEHPYALTPEGSEPTDICDEEHRAYFARLKEPAETVGLNMQLPPEIRPRPMTYLAFEGAVLAEKSGKHEAWSDRVYRAYWVEGRDIGQIDVLCVLAADIGLNADEMRQALENRAYADDVKAAIQHTLDTYHPRGVPILFVNGQRIRLRAYTLPEMTDVLRGVIPVEENQEETGCSADGCRLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJZ8</accession>
    <name>R7IJZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA ligase</fullName>
            <ecNumber evidence="11">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ligA</name>
        <name evidence="13" type="ORF">BN770_00714</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="11"/>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51950">
        <property type="protein sequence ID" value="CDE51950"/>
        <property type="gene ID" value="BN770_00714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="590"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="11">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE51950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="668" mass="74118" checksum="028F814CB4310B13" modified="2013-07-24" version="1">MTDQTARMRQLTDTLNQASQAYYFGSEPIMSDMEWDKLYDELSALEKETGIVLPDSPTHRVGGEVMTAFAPHTHIHRLWSMDKAQSIGAVEDWIRRTEKLSGQDDLQYCVEYKFDGLTLNLTYNEGRLIQAATRGNGITGEAILPQAKTIRTVPLTIPYQGLLEVQGECIMRLSALDTYNKTAKEPLKNARNAAAGALRNLDPAVTASRHLDAFFYQIGTIDNPPYTTQQGMLDFLRANGFQVSPYLGQCRSIREIEDCIHHIEEERSSLDFLIDGVLIKVSDLSIREMMGYTDRFPRWAIAFKFEAEETTTVIRDVTWDVGRTGKLTPVAHVEPVDFYGVTVRKATLNNWGDIQRKRVAIGARVWIRRSNDVIPEIMGHVGDSEEGETPIVRPEVCPACGEKLIERGAHIFCMNRVSCRPHPHVFYINPVPCRPQAVARISHFASRDAMDIEGLSEKTAGQLYDQMNVRDPADLYTLTREQVLSLDGFKDKKADNLLSALEKSKHCELDAFLFAVGIPNIGRKTARDLANAFGTLEKVSNATQSELVALDDVGDIVAQSITEFFSFDENREMIRRLLAAGVTPAEKQKLEGGVFAGMSIVVTGTLPTLSRKEAEDLIARSGGKPASSVSKKTAFVVAGEAAGSKLTKAQTLGIEVIDEAELLRRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK70</accession>
    <name>R7IK70_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51856">
        <property type="protein sequence ID" value="CDE51856"/>
        <property type="gene ID" value="BN770_00655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448047" evidence="1">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="92" mass="10726" checksum="60C57C7883D1AE8B" modified="2013-07-24" version="1">MKNIKYTVSHPIFVFMKKHFCPHCKAALTVETAHHLVNSRSEEAKNYDFSTEDGRMIGTVDFRNPYFACPNCHAEFSVEELWKMEKGKRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK81</accession>
    <name>R7IK81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51871">
        <property type="protein sequence ID" value="CDE51871"/>
        <property type="gene ID" value="BN770_00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="221"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="408" mass="45910" checksum="E40D0ED069D39905" modified="2013-07-24" version="1">MQQATKQPAVLLVHDYYQVPGGEDVVVANEKHLLETHGHAAALYARRNEEISRMGAPEKIRSALGMFFSIRTYREVRRSIRENRISLVHVHNTLPLIGPAVYYAAFREGVPVVQTVHNFRLLCPNAIFYRDGHICEDCTKKGLHCAVKHRCYRGSRLQTVLCVLSTRLHRALKTYSRLHYITLTDFNRQKLLALEQIPPDNVSVKPNFVEPPETIVPYAARENQVVYIGRLDALKGIRLLLEAWARYERSGGGMKLIICGTGPEETWCREYLTREKLKQVELRGFVPNSAARALMGQSKALILPTQWYEGFPMTIVEAFSVATPVICSDLGNAGSLISDGVTGFKFPADSAEQLAQTLNRLQHAESVSEGALKTYQENFTAEANYRRLMAIYSKAMQKSGERNEPSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKB1</accession>
    <name>R7IKB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000189">
        <property type="protein sequence ID" value="CDE51052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51052">
        <property type="protein sequence ID" value="CDE51052"/>
        <property type="gene ID" value="BN770_00281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="68" mass="7350" checksum="1CB56D67A05923F6" modified="2013-07-24" version="1">MFKLETMIYASEDGTSSVFTLNPALQKQLDALAAQHPEVCQRKARGEAGGVTYQVRDAALAIQPVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKF1</accession>
    <name>R7IKF1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">BN770_00603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000243">
        <property type="protein sequence ID" value="CDE51763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51763">
        <property type="protein sequence ID" value="CDE51763"/>
        <property type="gene ID" value="BN770_00603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="46"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="482" mass="55328" checksum="2C88ADD6CBA0D306" modified="2013-07-24" version="1">MAKEKKQEFVTHITPRDEDFSQWYTDVILKTELCDYAPVRGCMIVRPYGYAIWERIQAEMDKRFKETGHQNVYFPMLIPESLLLKEAEHVEGFAPEVAWVTQGGTEKLQERLAVRPTSETIFCTMYAKWVQTWRDLPMKYNQWCSVMRWEKATRPFLRTSEFLWQEGHTIHATAEEAQEETMQMLHVYQEVAENVMALPVYVGQKSEKEKFAGARATYSMEAMMQDGKALQAGTSHNFGTNFAEAYGIQFQNKEGKLTYAEETSWGVSTRLIGAIIMTHGDERGLRLPPRVAPIQAVILPIAAHKPGVMEACEKLLEELKAADIRVKLDDRDTVSAGYKFNDWEMKGVPVRLEVGPRDLENGVVTVFRRDLCEKVTLPLENLADELKALLDDIQQTLFDQAKKFRDEKTHVVHNMEELGAAVENGFAKAMWCGERACEDEIKEKFNASSRNMPFDQEKEWFGDTCVCCGKKAKKVMYFAKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKK7</accession>
    <name>R7IKK7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TelA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51833">
        <property type="protein sequence ID" value="CDE51833"/>
        <property type="gene ID" value="BN770_00643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026508">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR026508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="407" mass="45157" checksum="7FC8F0035172305F" modified="2013-07-24" version="1">MADQFPMLSLTPDVPDPVAPSAAPAQSIQQQPAAAASTTSEPLAAPTAAAAQPQASAQATAPRLDQSQLTPAERAAIEDFLTKLDITNPDHVLLFGADAQKHISDFSESALQAVRTSDTGEVGKMLENLVVELKGFEADAEEPKGIFKIFHSADNRIERMKARYNKANVNVENIATSLEGYQAQLLKDVAMFDRLYDQNTAYFRQLTLYIIAGEEKLQRVREGELKELMAKAAESGDAMDAQKANDLAAQCDRFEKKLHDLKLTRQVSMQMAPQIRLLQNNDSLLVERIQSTISNTLPLWKNQMVLALGLHHTQQAMQAQRAVTNMTNELLKKNAETLKMSTIETAKESERGIIDIETLVQTNQSLIDTISEVMTIQQEGHTKRVEAEKTLYQMENDLKKKLLETKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKX2</accession>
    <name>R7IKX2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51968">
        <property type="protein sequence ID" value="CDE51968"/>
        <property type="gene ID" value="BN770_00723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448401" evidence="1">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="261" mass="30014" checksum="D38043C7E9874134" modified="2013-07-24" version="1">MWKRGAAFLTALLMLFSCALAEDVYLDEPTTGAAEETSDDTLTARDDLINRIIALGQELYIKANGKSQRAHYKRDIYVCKNFTTYLFRQNRDDFCMAEYPDVQLLVPNNLSAAKSKPYSYGIEWEDISPEKGNPFYIAAQFKYDKNLSEEENMALACDFMRQAQRGDYFQMSAKYEYGTGAHSAIMLGYDPETDEIHWMDSNMRGGKKKGIRYGLVQFDEVKSVEWWASTFCKKTRGATLYRLRDDIVYRPGHEPENTTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKY9</accession>
    <name>R7IKY9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000253">
        <property type="protein sequence ID" value="CDE51988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51988">
        <property type="protein sequence ID" value="CDE51988"/>
        <property type="gene ID" value="BN770_00737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="102" mass="11014" checksum="1374DB8EA41DD9FA" modified="2013-07-24" version="1">MQVLHILLLVFIISCAVSVSLTKNLLTALVIFMGQSLAMSVIWILLESPDLAITEAAVGAGITSLLLFVTLKKIHAIDIQKGTDKTTNNVQEGVTRHGEDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL71</accession>
    <name>R7IL71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyco_hydro_4C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000216">
        <property type="protein sequence ID" value="CDE51362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51362">
        <property type="protein sequence ID" value="CDE51362"/>
        <property type="gene ID" value="BN770_00396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="9">
        <location>
            <begin position="212"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="463" mass="51572" checksum="6EC108400DBE39B3" modified="2013-07-24" version="1">MYTHQGNKVTGLTVAYIGGGSRGWAWGFMRDIISDGQISGTVRLYDIDREAAERNQKIGTMLAAHPDAASKWAFEVSSSLQEALTGADFVVISILPGTFAHMRGDVHLPERVGVYQSVGDTVGAGGFMRAMRTIPMFVEIAEAIRDFAPNAFVINYTNPMTLCVRTLYEVFPQVKAFGCCHEVFGTQKVLCAMLDEQEHIPGVKRQDLYTTVTGINHFTWITSASYQGMDLMPLYARFVEEHPEGIQLGSDNWMNSHFACAHKVKFDLFQRYGAIAAAGDRHLVEFLPQWYLHSPETAHQWKFDLTPVSWREDDLKKRMQRSDDLLSGKEPLDLTPSGEEGHLLLKALLGLGNMVSNVNVPNQGQIPNLPIGAVVETNALFSRGRIDPICAGDMPANILPLVARHVYNQENTLQAALHCDRKLGFSTFMNDPQLGGVTLEDGQKLFDDMLLHQRDVLPKGWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILG9</accession>
    <name>R7ILG9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific recombinase phage integrase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000223">
        <property type="protein sequence ID" value="CDE51472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51472">
        <property type="protein sequence ID" value="CDE51472"/>
        <property type="gene ID" value="BN770_00459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="157"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="382" mass="43886" checksum="42FCE01E833E78AB" modified="2013-07-24" version="1">MPRQKLTQRTDGYFKVKYHDKQFYGKTQAEAMKARDAYKQKEQMGLSHDLEGITFLDYALNWLEIYRSDCSVPLQKQYASMIRFAADHTRKRFICDINANDLQAIFNKLSCYSSSYVSKFASLMNGIFRNAVSNGALIRNPMAGVQRPKCKKTGGHRCLEPWERALIRSTWQEHDFGLAAMVMLYTGFRRGEMLHLNIDRDVDFEKKTIAVRGAVSFSEGNRPKLTKGKTASAIRTVPLLPPLEEALKGRHGLVCHKENGGIMSQSAFACKYESYITFLETKLNGIHKRWYGKTNEQKQLLAEGKLPPWKEINIRCHDFRVEFCTRAYYAQVPLKTLQSWMGHADADMILAIYTKLDKEQERTDAAKMVNYLTRLEVDSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILY9</accession>
    <name>R7ILY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51647">
        <property type="protein sequence ID" value="CDE51647"/>
        <property type="gene ID" value="BN770_00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="305" mass="34824" checksum="4DF0DD43867DEE8B" modified="2013-07-24" version="1">MNNRRLITEHERPLTASGFRVMKGEREFITYQRDVTIRVWHQPNPDSYAPHFHSAIEVCVPLLGGCEVAVKGKEYHVQAGEVLFVPSDATHALRMTAGSERYLIIFEHNAAFTMKEFAALRPMLRQPIYLTAESEATPIVRKTLMQLVDAYEAYTPLRNLRCYALLMDVFATLGELYLPNVANSAEMNDIHRRLSGEDAFNRALDYLNKNYAENITLDVLADYAGFSRYTLSRMFSRHTGATFIQYLNARRVDMAAEMLSQSDLPVTQVALRVGFGSIATFNRVFRTQKGCTPSQYRNVYLELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMH9</accession>
    <name>R7IMH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51817">
        <property type="protein sequence ID" value="CDE51817"/>
        <property type="gene ID" value="BN770_00627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448436" evidence="2">
        <location>
            <begin position="22"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="325" mass="35452" checksum="BCDF067BF0AAA5D7" modified="2013-07-24" version="1">MKRLLMLLTTFCLLLMTTALAETEADWNAKCEWKTGTGTTLYAVTQGTATSSDLSDFVPVGTLPANTYVGILERSGNMRNVRYWNGSGTSSGWVDSAALVWVGSNSSKPKPSGSRATASDLSRKPDDTWNSLTVTYSDGDEAQTVSLQTLGVAMSEIYMDGEFLRVPTASLSWETEADDDQRIAVIYAPSTGKCTMREEASKKGKIIMTCKAGRVVTVLRVGDVYTRIVYDGVEGLVLNSCLKFYETPDEDAFTTGLLSAKGKTNTTATVSVYQLTKSRRRLDKIRVGAYLAVMDKVGEWYEVDVNGWHGFVKDANVTLDAPLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7I2S8</accession>
    <name>R7I2S8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgC</name>
        <name evidence="12" type="ORF">BN770_00779</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46204">
        <property type="protein sequence ID" value="CDE46204"/>
        <property type="gene ID" value="BN770_00779"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE46204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="393" mass="42719" checksum="29AA2EB0034F6160" modified="2013-07-24" version="1">MKKKTCVAMLLAGGQGSRLGVLTKKVAKPAVPYGGKYRIIDFPLSNCTNSGIDTVGVLTQYMPLELNSYIGSGAPWDLDLSTGGVFVLPPYQTGKTGDWYRGTANAIYQNMAFIEQYDPDYVLILSGDHIYKMDYNAMLQYHIRKGADATIAVRPVPWEEASRFGIMNTDADDNIVEFEEKPKQPKSNKASMGIYIFSWAKLRAYLTADEADKTSANDFGKNIIPAMLNDKQVMVAYNFEGYWKDVGTIESLWEANMDLLSVPMPIDLHDKKWRIYAKNPGLAPHYIAKGAVVSDSLVTEGSEVYGSVQHSVIFAGVTIEEGASVIDSVVMPYAVIKRGAVVRRAIVAENAVIGAGCVVGEETGNIAVVGQGVTLPAGVSVTAGQQVDENTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3J8</accession>
    <name>R7I3J8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">BN770_00891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46479">
        <property type="protein sequence ID" value="CDE46479"/>
        <property type="gene ID" value="BN770_00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="70" mass="7811" checksum="3F65C9D41103D30C" modified="2013-07-24" version="1">MGKFCEICEKGTLNGNNVSHSNRKTHRTWAPNVQSVRVVVNGSAKRMNVCTRCLRSGNVMRALPKTHEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3V7</accession>
    <name>R7I3V7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46584">
        <property type="protein sequence ID" value="CDE46584"/>
        <property type="gene ID" value="BN770_00951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="388"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="637" mass="70907" checksum="074F2A79D239A53D" modified="2013-07-24" version="1">MTQKSSKLTLGMLGKVFGVAFFVYLFFGFMLLPCLNTITQIFTTTDSAGNIDPLAVIRFFFAGNMPSYVLNSLKLAVCLVITVNIVGISIVLLTEYFDIKGAKILRLGYMTTLIYSGVALVTGYLFLYDSDGIMTTWLSGIFPNMDKNWFSGFNAVLFTMTFACTSNHALFLRNAIRAIDYNTVEAARNLGAKPFKVLLKVVFPTLIPTLFSLTVMTFITGLCAMSAPTLLGYDSINPEIVRLAGSSSADEAFPQARAALLSIILAMFTIILLTVLSSYERKGHYLSVSKTKAKLVKQKITNPVANVLAHIYAYVLFIIYMTPVVMIVLFAFQNYPAIRSKTLSMDQFTLINFFGQQDYEFLTNRGKLKTRTGAISGLFANADTVGGIRLSFVLSAIAAALACVIVVVAVNYIFKNKGKKRGTVLEYSLLFPWLLPTILICYSYRTYFNSDSVWYVFNNNLYMRENVRFLIVMAYTVVKLPFALRMIKAAFYAIDEELEDAARNLGASSLVTFLRVKLPIVLPSVLAVFALNFNALFTEYDMSATFQSSYGKTYAMIIQNMCAEEGRDGYNVNASGRRCASTVFIMVISGLILYLVYGVGARDLGERIERREKRRKRIEAFKAKFTGKKKAAEKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3Y3</accession>
    <name>R7I3Y3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46186">
        <property type="protein sequence ID" value="CDE46186"/>
        <property type="gene ID" value="BN770_00767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="174" mass="20013" checksum="CEC81F9142CE2CEB" modified="2013-07-24" version="1">MDELRLAIPDESLLDEIAAYRQAMLDADSSMDGCGPLKRMENPAEWLAFCRQLDNPATTPPNWVPMTQFVCLRGEKIVGMIQVRRELNDYLRNYAGHIGYSVRPDERQQGIATWMLHNVLTYCREIGLKRVMVACEPWNVGSRKTILRNGGVYEKTVHEDGENINLEHYWISLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I498</accession>
    <name>R7I498_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMN-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46470">
        <property type="protein sequence ID" value="CDE46470"/>
        <property type="gene ID" value="BN770_00882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="108" mass="12225" checksum="6B85A89CBCD03BDB" modified="2013-07-24" version="1">MARADGRHYQLTSGSWREQMDAYQNMMVGMTVDEVETWFGRYFSAENGRPLTENSSSDADRARWEAFSDDDRARAADIVSGATMSLRDAHGDILTAIRRAWEDAQKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4A9</accession>
    <name>R7I4A9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="13" type="ORF">BN770_00892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46480">
        <property type="protein sequence ID" value="CDE46480"/>
        <property type="gene ID" value="BN770_00892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="4"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE46480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="598" mass="67106" checksum="AE9625F62F3A0B1E" modified="2013-07-24" version="1">MKQITSAQLREMFQQFMESKGHHRIPSASVIPENDPTVLFTTAGMHPLVPYLMGTPHPAGTRLTDVQKCIRTGDIDDVGDPSHLTFFEMLGNWSLGDYFKKEMIPWSWEFLTSEKYLGLDPDKLAFTVFEGDEDCPRDEEAANLWRSCGVKDDHLFYLPKEHNWWGPAGITGPCGPDTEMFIITKKPCGPNCSPACHCGAYLEIWNDVFMQYNKQKDGTFIPLKQKNVDTGMGLERTICVLTGKKTVYETDAFTDILAKIAELSGKEYGADEETTKAFRIIADHMRTSTFILGDDRGVSPSNTDQGYILRRLIRRAVRYGMQLGMPDGFTCEIAKVIINQYKNAYPELERNAAFVIDQLTLEEGRFARTLKQGNKEFDKVASRAADGKIDGETAFHLYDTYGFPIEMTVELAKERNLTVDTAGFEEAFRKHQELSHQGAEQKFKGGLADTSEETARLHTATHLLHAALRKVLGDEVAQKGSNITAERLRFDFSFGRKVTKDELAQVEKMVNEAIQAKVPVVCEEMTVPEAKEKGAIGLFESKYGEKVRTYKMGDYSFEICGGPHAQNTGDLGTFKIQKEESSSAGVRRIKAVLIPDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4I4</accession>
    <name>R7I4I4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YtfJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000011">
        <property type="protein sequence ID" value="CDE46391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46391">
        <property type="protein sequence ID" value="CDE46391"/>
        <property type="gene ID" value="BN770_00853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014229">
        <property type="entry name" value="Spore_YtfJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39162">
        <property type="entry name" value="PTHR39162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09579">
        <property type="entry name" value="Spore_YtfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021377">
        <property type="entry name" value="YtfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02874">
        <property type="entry name" value="spore_ytfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="124" mass="12920" checksum="8D3106E521E58E65" modified="2013-07-24" version="1">MEHPISELMQTAMSSMKDMVDVNTVVGHPVQASSGSTIIPISRVTFGYMTAGGDLLADKPAKDAPDFPFAGGSGAGVSLQPVGFLVLSGDTVRMLPATCATVADRVVDLIPTVVEDVKSFLTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4T7</accession>
    <name>R7I4T7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YARHG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000028">
        <property type="protein sequence ID" value="CDE46889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46889">
        <property type="protein sequence ID" value="CDE46889"/>
        <property type="gene ID" value="BN770_01071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025582">
        <property type="entry name" value="YARHG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038434">
        <property type="entry name" value="YARHG_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13308">
        <property type="entry name" value="YARHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01324">
        <property type="entry name" value="YARHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435387" description="YARHG domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="YARHG" evidence="2">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="290" mass="32402" checksum="0000D6A012AC4E2F" modified="2013-07-24" version="1">MKQARWMLMVLAALLLSIGIASAELNYILPDSNSRELTWDEVARWDYETLGYAFNEIFARHGYVFHPGEKYDNYFSCQPWYTPNRDTNNQRAVYPYLNTTEWANYELIKEVRDYKAENGDSGESMWTYFSGGFDTLGGFDYVQLRTGQNLPVYSAPSRNSWRGANGKASVGTNGAIYSAGWENGWLLVMYETNSGSVRVGYVSGDDIRGGVPMDTSLTFSYAAATLNAGTALTDDPAMRKTTIAQLRAGTQVTYLTSFFNKSAWDYIETTVDGQTTRGFVPAGCLTIYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4X5</accession>
    <name>R7I4X5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46929">
        <property type="protein sequence ID" value="CDE46929"/>
        <property type="gene ID" value="BN770_01078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025277">
        <property type="entry name" value="DUF4038"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032260">
        <property type="entry name" value="DUF5060"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041239">
        <property type="entry name" value="DUF5605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13204">
        <property type="entry name" value="DUF4038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16586">
        <property type="entry name" value="DUF5060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18310">
        <property type="entry name" value="DUF5605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5060" evidence="3">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4038" evidence="2">
        <location>
            <begin position="100"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5605" evidence="4">
        <location>
            <begin position="442"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="511" mass="58566" checksum="A963C77FD23E7EE9" modified="2013-07-24" version="1">MNMKQYETFELRFGGEVLPDAWAQIDLTATFSCAQESLTVKGFYDGESDGQGVYVVRFLPQYAGVYRYQVRGAVTAEGEIVCEASSPEAHGIVRAVGTHFAFADGAPYIPFGTTVYALISQDDALVEQTLQSLAAAPFNKLRLCVFPKDYDYNHNEPPLYAFARRENGSWDTSRPSIAFYQRLERILRRIAALGIQLDLILFHPYDRWGFAAMPQADNIRYLDYLLRRLSAMPEIWWSLANEYDLCMPKKTLADWEALEAFVASCDPYHHLLSCHNCFCFWDFKRKDVTHASIQTRVLTEIPRYLREYGKPVVIDECCYEGDLPHIWGSISGQEMVRRFWRCYVGGGACTHGETFLSPDDVLWWARGGVLKGESPKRIAFLRRVIEELPGFLSPLESVWEEAERQDEAQRPDWIRPFLASLSRMAPPDRHMLLCGEHLWAAHCAEDAYLWYYGQQTAREQIIKLPPAHRYRVEVLDTWNMTRETLQTGVSGCVVLTLPGREDMAVLAVRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4Z4</accession>
    <name>R7I4Z4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">BN770_01005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46705">
        <property type="protein sequence ID" value="CDE46705"/>
        <property type="gene ID" value="BN770_01005"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="142"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="257"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="383" mass="41251" checksum="A87D9DD44CDEFB38" modified="2013-07-24" version="1">MQTIAILGSTGSIGTQALELVRLHPEEFRVVALTARSSREKLFEQVREFRPEVAGLTEPIPMSEIPEDVRFCRWVMGADALHAAAAEVPADMVLVSVVGIAGLQSVMDALGANRQVLLANKEALVTGGHLVMDAAKRIGKPILPVDSEHSAIFQCLQAAGGNQPVRLLLTASGGPFRTWTREQMQNATRAQALKHPNWSMGAKITIDSASMFNKALEIIEAHWLFDMPPEKIQVVVHPQSIVHSAVEFADGAVLAQLGVPDMRVPIAYAMTYPRRIPTGSKPLDLFSIGTLTFEPGDPVRFPALRLAGECLNAGGAACTILNGANEMAVAAFLRDEIPFGAISRIVEGTLEACGAMPADTLEDIFHADLEARRVAKEIAEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5I4</accession>
    <name>R7I5I4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein insertase YidC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47139">
        <property type="protein sequence ID" value="CDE47139"/>
        <property type="gene ID" value="BN770_00079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="340" mass="38641" checksum="F658A682C4F14F81" modified="2013-07-24" version="1">MGINEFLKTILEWIYGFVGNYGWAVVLFTLLVRLIVMPFDYKSRVGMRKMQKIAPMQAKLQKKYEKDPDKMNKKLQELYREQRVNPLSSCLPMLISLPILFAMFTAMRMVANEHLAQQAFDIIASGNPALDSWLWVKNVWMPDSPFAAAWPNLDSLRQIATNEWLAVFNKLPQETLALLADKGLALTAESFAGDALNTTIQTIYTTMEQLPAYMEHVKYYSDLTIPLFNIHIFVNYNGYFILPILAAGGQFLMTKLTGTAQTPAADDAQAQQAQNSMKFMNYFFPIFTLILCFNYNAIFALYWVASNVIAIVQTKGINMYLDRKEALEAANPNKNTGSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5I6</accession>
    <name>R7I5I6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46528">
        <property type="protein sequence ID" value="CDE46528"/>
        <property type="gene ID" value="BN770_00922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="43" mass="4980" checksum="D4C2EF30AC2F2AF2" modified="2013-07-24" version="1">MTNKENEQQETPQYETVSDEILLKIGLQLIEKNRQAYDALARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5T3</accession>
    <name>R7I5T3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">BN770_01049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46841">
        <property type="protein sequence ID" value="CDE46841"/>
        <property type="gene ID" value="BN770_01049"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="150"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE46841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="34094" checksum="2A5E63E77C98E86D" modified="2013-07-24" version="1">MRHLIDITDLSVDEIESILDLADKMKANPAAYRDTMHGRILATLFFEPSTRTRLSFESAMLSLGGSVLGFSSADTSSATKGESLMDTIHTVSCYCDIIAMRHPKEGAPMAGTLTSRVPIINAGDGGHNHPTQTLIDLLTIRTARGELGHVTIGMCGDLKFGRTVHSLIGAMSRYPGVEFVLISPPELRVPAYITQKLADDGIPFREVETMEEVMPELDVLYMTRVQKERFFNEADYIRLKDTYILDPDKLKTAKPDMAILHPLPRVNEISTKVDADPRAMYFEQVRNGRFVRMALISTLLEGLYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5U6</accession>
    <name>R7I5U6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46856">
        <property type="protein sequence ID" value="CDE46856"/>
        <property type="gene ID" value="BN770_01055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="SSF54403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447541" evidence="1">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="251" mass="27482" checksum="0DEB2C966DEBF8AE" modified="2013-07-24" version="1">MKKLISLLLALMMAILAIPALAEDAQDPDMAFDPDIDPDFLVGAWESWTGNPLEIPDDVKYIFDRATDELIGEPYNYEAIAILGTQVVAGTNYCFLCRKISYETGETIGYTLVYVFYSLNDDVELLNEQDIVFAPDATSPKVAESTDANGEILPGAWVNWAADPLDIPENVKAAFDKALEGLVGHTYEPIAILGTQVVSGMNYCLLCKTTVVTPDAPVSYTLVYIYEALDGTAEIMRIQDIVFDAFPAENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6B5</accession>
    <name>R7I6B5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urocanate reductase</fullName>
            <ecNumber evidence="3">1.3.99.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>A + dihydrourocanate = AH2 + urocanate</text>
            <dbReference type="Rhea" id="RHEA:36059"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:27247"/>
            <dbReference type="ChEBI" id="CHEBI:72991"/>
            <dbReference type="EC" id="1.3.99.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.33" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46758">
        <property type="protein sequence ID" value="CDE46758"/>
        <property type="gene ID" value="BN770_00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="1 3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022253550" description="Urocanate reductase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="4">
        <location>
            <begin position="42"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="634" mass="65446" checksum="302191E73488332C" modified="2013-07-24" version="1">MKTMLSKLTSVLLCLAMLLTMCSFAMAEAGTYTGVGDSEIGGKGAIEVSVTVDENGVVTDIQVTKNGDTAGIADAAVEAMPGRIMAAQSANVDGVSGATMTSEAIKMAVLDAVTAAGLDTVKWSTYVATEAAKADDATYNTDIVIIGAGGAGMTAALTAAEKGADVIILESQAAVGGNSVRATGGMNAADTPAQDENEFGESAGVEKTLKTARTTYADNVTITKLAEEVEKQWADYQANPVGYFDSDELMELDTMIGGKGINNPELVEELADESADGVEWLKKYGINLTSVGSFGGASVKRIHRPVNAEGKTIAVGSYMIPLLEKACEENDKISIQLETTATTILTDENGKAVGVKAVGATGNEVTVNAKAVILATGGFGANLDMVAELVPALKGFMTTNAAGAQGQGIEMAQALGAATVDMDQIQIHPTVQFDTAALITEGLRGDGAVLINAEGKRFIDEVGTRDVVSAAEIAQPGSYSYLVVDQAMLDKSSVIAGYVKRGFVFQGNTYEELAEALGVDAATFAETMNTWNTYVEAKNDPDFGRTSFAQPLNTAPYYAIKVTAGVHHTMGGLVINTDTEVLKADGTAIAGLYAAGEVTGGVHGANRLGGNAVADFVVFGRIAGEEAAEYALGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6M6</accession>
    <name>R7I6M6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000052">
        <property type="protein sequence ID" value="CDE47519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47519">
        <property type="protein sequence ID" value="CDE47519"/>
        <property type="gene ID" value="BN770_01275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="112" mass="13005" checksum="4FD4FECDDEC56D2F" modified="2013-07-24" version="1">MWAIFEQLRDHATTIVGLVTALTLMYSWFRKPMKQLIAREQQQEEDLAILTWAFLQNAHDNYTRQGWCTAAEKEQVLNMHKSYAAKGRNHLSASYEQDILALPETPPGRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6X3</accession>
    <name>R7I6X3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argR</name>
        <name evidence="10" type="ORF">BN770_01117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47023">
        <property type="protein sequence ID" value="CDE47023"/>
        <property type="gene ID" value="BN770_01117"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="9">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="149" mass="16458" checksum="6DDC9965116952ED" modified="2013-07-24" version="1">MKTVRQVAILDIIEKQEIETQEELASSLNARGIRVTQATVSRDIKELRLLKVLTPSGKYKYATGDQADNNLTDRFIRMLAESLLSVSSANNLIVVKTLSGSANVAAEALDSMHWPEVLGTLAGDNTVLLIIRSNEETITVTSRIREMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I724</accession>
    <name>R7I724_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47256">
        <property type="protein sequence ID" value="CDE47256"/>
        <property type="gene ID" value="BN770_01184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="177" mass="20560" checksum="63667EBB71FA738A" modified="2013-07-24" version="1">MDRFLEESVSKHHRAAEEVLYYASWVVMIVSAILAFMYLNVMFYSFSISMLVMTLVFTGIAVYIFFFHDRLRTEYDYTFTNGSMDFAQVFNNRKRKALGSLNVAKVDAFGKVASGSFHRHVSAPGVKQLRWFLNRDAELYYFAFSKDGKKSLIVFEPSKAMVDNIRHYLPFGAYQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I725</accession>
    <name>R7I725_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1540 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47083">
        <property type="protein sequence ID" value="CDE47083"/>
        <property type="gene ID" value="BN770_01139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="55" mass="6175" checksum="4CE38EB72F5BA3E7" modified="2013-07-24" version="1">MSHKNNQCIHCSVESCQHHEQDGVCGLMDVQIAPKECCCNGKADESLCSSYKCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7H5</accession>
    <name>R7I7H5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47585">
        <property type="protein sequence ID" value="CDE47585"/>
        <property type="gene ID" value="BN770_01298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="357" mass="38145" checksum="765F87D55BD652B3" modified="2013-07-24" version="1">MKKTMKKSTKGFLNNLITYAIVIIAFVFTQMALSKMIPGVTISRSLKGQLIPICVYIVMAVSLNLTVGISGELSLGHAGFMSVGAFSGIIMSGWLLNAFQMENETMRLVLAMLAGGVCAAIAGVLIGIPVLRLRGDYLAIVTLAFGEIIRNVMNCLYFAVSDGKLIVNFNNPRIDGTLLYNGPAGAVRVGRIATFEAGFVLVLLTLFVVLNLINSRSGRAIMASRDNRIAAEAMGVNVTKYKLMAFVTSAALAGMAGALFGLNFSSIAPDKFKFDTSILVLVFVVLGGIGNIRGSVIAAALLTVLPEVLREFGDYRMLIYAIVLIAVMLLGNAPVVRQVLERIRPAKKEVVKEGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7H8</accession>
    <name>R7I7H8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46477">
        <property type="protein sequence ID" value="CDE46477"/>
        <property type="gene ID" value="BN770_00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="142"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="262" mass="28232" checksum="63CFA1C635C7768A" modified="2013-07-24" version="1">MAEKSPFFRNFASHILPVLTFATLLVGTALVGVALTRIPQRPTDAAPPSPTPETTYIAAGSLTGRTILVDPGHGGYDGGARCRDSGVWEKEVNLAVALAVEKSLTQRGATVLMTRRTDTDLCDDTTRPANVTKKRQDMQCRVDMAVQGQVDMVLSIHMNEYRVRSESGPQVFYRAGSGAGRLLAGTMQEALITALSPQKERAAMPGDYFILQLDTPSVLVECGFISNPAEEALLLSPAYQEKLGEAIADGAAEYFRLAQAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7J1</accession>
    <name>R7I7J1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xylB</name>
        <name evidence="8" type="ORF">BN770_00901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46492">
        <property type="protein sequence ID" value="CDE46492"/>
        <property type="gene ID" value="BN770_00901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="257"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="507" mass="54891" checksum="B992BEB010D452AD" modified="2013-07-24" version="1">MKYVLGIDLGTSGTKTVLFDQYGTAVCSALVEYPLYQPHNGWAEQKPEDWYHAAVDTIRSVLTKSGVDKKDVVSMGISGQMHGLVMLDEAGNVLRPSIIWCDQRTAAECDQIHEIVGRDQLISITANPALTGFTLSKLLWVRNHEPEVYAKCRHILLPKDYVRYMLTGDFATEVSDASGMQMLDVPNRCWSEKLLNMLNIDPSLLAKVYESCEVTGHISKAAAELTGLSEDTLVVGGAGDNAAAAVGTGVVEDGRAFTTIGTSGVVFAHTDKLAIDPKGRVHTFCCAVPGAWHVMGVTQAAGLSLKWFRDNFCMAEKEAAALMGEDPYNLMNKQAAQSPIGANKLLYAPYLMGERTPHLDADCRGMFFGLSAMHTRRDLLRAVMEGVTYSLKDCLNVLAEMGVAPETMLACGGGGKSPLWRQMLADVFQMPVATTVNTEGPALGVAILAGVGAGLYASVPEACRAMIHVNPAQNPIAENVPQYEKVYALYTKLYQANKGLYKELAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7M1</accession>
    <name>R7I7M1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">BN770_01391</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47854">
        <property type="protein sequence ID" value="CDE47854"/>
        <property type="gene ID" value="BN770_01391"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="115"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE47854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="252" mass="26920" checksum="22158C74CC352316" modified="2013-07-24" version="1">MTILISGACGFMGREVAAQAKSSGIDVVCGVDIAAGVAPYQPDFPLYANYADAPKADVVIDFSNWKPGANVLDYAMKYRVPVVIASTGLTDEQLHQIAEASKVVPIFRSGNMSLGIALLRALAKKAAGVLGDAFDVEIVEAHHNRKLDAPSGTALMLLDAVKSAYPDEREAVFGRHGRDCKRQHQEIGMHSLRGGTVTGEHEVCFFGTGERIRISHSAENRGVFAAGALRAAAFLMNQQPGMYSMDDVVGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7M2</accession>
    <name>R7I7M2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47253">
        <property type="protein sequence ID" value="CDE47253"/>
        <property type="gene ID" value="BN770_01181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8494" checksum="9970428E03F48C60" modified="2013-07-24" version="1">MWILLPAFVLTLLLCRCYRPGTWGARLLNCWTFGTVLLMAWNLLPLPHVGINPISSLLTGALGISGLPLTVFLNMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7N6</accession>
    <name>R7I7N6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ybeY</name>
        <name evidence="13" type="ORF">BN770_01404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="3">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47869">
        <property type="protein sequence ID" value="CDE47869"/>
        <property type="gene ID" value="BN770_01404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="171"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE47869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33155" checksum="7BCED8F2E143C52D" modified="2013-07-24" version="1">MKLLWQIDTQVDPRYLSLMQTAADCAVWMEGVSRPCAVNIRICDDDAIHEINREYRGVDRATDVLSFPTVNYPAGKTAGQCDKLLARELDDEVDACMLGDLIISMPHVLAQAAEYGHSPEREAAYLTVHGLCHLMGYDHIEDEDKKEMRAMEEKILSAIGMTRDGEMQTPVSDETLLEMARQAMLRSYSPYSGYPVGAALLCADGRVFQGCNIENASFGLTNCAERTAMFKAVSEGAREFTAIAIASRDAAPWPCGACRQVLNEFAPNIRVLVTWQGGTESATLPELLPHGFGPQQLTTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7W3</accession>
    <name>R7I7W3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47591">
        <property type="protein sequence ID" value="CDE47591"/>
        <property type="gene ID" value="BN770_01302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="335"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="555" mass="60495" checksum="A56A990791FB42BB" modified="2013-07-24" version="1">MKNRLSSRLRLTLSGVTLLTLLLMCVLVFAGMYFQTTADNREQLRQQAVQLSSYLEASDDPVSLLQGSVFTQRVTYLDTDGTVLYDSEVDASRLESHAGREEFQQARENGEAFTARSSATLGQTSLYYAKRLADGRVIRVSGTQRGMLRQVRDLLGYLLLGAVLCFGAAMAFSRPLAKRLAAPMNEVNLDQPLESDVYEELSPMLRRMAQQNARIADQMASLTAQRHELDTVLGGMKEGFVILDETRHVLTMNNAARAMFCITNDPVGQPMIAVSRDEALLRLLDGQGTECAMQLNGMTIHLSLSHVEGGGTALLMQDVTAAQAAEASRRQFSANVSHELRTPLTTISGYAELLSSGMLQKPEDATEFGRKILAESRRLLTLIEDIIRLSRLDEGVRGEVTPVDLTALIQHCVQKLTPAAQNVQVSISASGNDPVLISGDHALLEEMLTNLLENGIKYNHAGGYVRARAEMADGRAVVTVADNGVGIAPEDQQRVFERFYRVDKSRSKQTGGTGLGLSIVKHGAQVHHAQIAMQSALGEGTTITLTFPAQSSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7W6</accession>
    <name>R7I7W6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47954">
        <property type="protein sequence ID" value="CDE47954"/>
        <property type="gene ID" value="BN770_01454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014578">
        <property type="entry name" value="Pesterase_CT488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033094">
        <property type="entry name" value="Pesterase_CT488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26762" checksum="F4ECC73361D6A719" modified="2013-07-24" version="1">MTLFAIGDLHLPGGEEKPMDIFGDHWENHFAHIAADWRARVKDGDVVLIPGDISWAMQLERAVPDLQKIGALPGRKVLIKGNHDYWWNSVSKLRRVLPEGMSALQHDALDMGDFVVCGTRGWMFPTGDAPLAPEDERILNRELLRLDMAICAAEKLAQGQKPIVVMLHYPPLLLTVLDTPFTQVLARHRVHTVVYGHLHGAGIRAGFNGEHEGIHYRLTSCDALGFRLTEVPLMTTISNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Y3</accession>
    <name>R7I7Y3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannan endo-1 4-beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47611">
        <property type="protein sequence ID" value="CDE47611"/>
        <property type="gene ID" value="BN770_01315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH26" evidence="5">
        <location>
            <begin position="12"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="307" mass="35122" checksum="B0515EF26C73409F" modified="2013-07-24" version="1">MFRPLCAENPLPAARRVYEYLQSLSGKCLTGQMESQWCRSTEHEISYLTDVTGRQPAIRGLDFMDNDYLGVTQRAKDWWARGGIPTICWHTGADFFSGYPECRESELDWAFAFVDGTEANRRLLDGLDHAVPYLKRLQSDGVPVLWRPFHEMDGGWFWWGRGGAANFVRLWRLMYDRYTHVHGLRNLIWVLGFSDATEDLRPWYPGDDVVDILGGDSYKGGAQGDLYRRCAALAPTGMPIVFHECGQIPTRAEMDAANAPWAYFMVWHTSWLTDSSKGNTPESLRAIYRDSSFVTLHQLPDFIESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I804</accession>
    <name>R7I804_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47999">
        <property type="protein sequence ID" value="CDE47999"/>
        <property type="gene ID" value="BN770_01481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="195" mass="20271" checksum="148FD4FC92780B99" modified="2013-07-24" version="1">MNTRNGNLVNLVTLALLMALIFLMGQTPLGLIPLGFCNVTLLVIPVAVGTLFMGLKYGVLLGLTFGATSFVSALLRPSTLVGTLMGASLPMVIVMTFLPRLMVPVVIHFVHKAMAHKLEKTGLAVAAACGSLTNTILYLGLMLIFYMICGIDNTAVLTAIGATAGGAGPLEAVAAALITPPIVLALRKAMHKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I820</accession>
    <name>R7I820_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PF04070 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46662">
        <property type="protein sequence ID" value="CDE46662"/>
        <property type="gene ID" value="BN770_00976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007211">
        <property type="entry name" value="DUF378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37304">
        <property type="entry name" value="PTHR37304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04070">
        <property type="entry name" value="DUF378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="66" mass="7210" checksum="C52F5C3FBF238FC0" modified="2013-07-24" version="1">MLIDTIALVLTIIGAINWLLVGVFQFDIVAWLFGGQGAILSRILYTIIGAAGVWCITLLFKNNRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7I878</accession>
    <name>R7I878_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="9">Holo-ACP synthase</shortName>
            <ecNumber evidence="9">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acpS</name>
        <name evidence="11" type="ORF">BN770_01357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000064">
        <property type="protein sequence ID" value="CDE47790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47790">
        <property type="protein sequence ID" value="CDE47790"/>
        <property type="gene ID" value="BN770_01357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="10">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="120" mass="12590" checksum="E62B124BF49F6E81" modified="2013-07-24" version="1">MSELRGIGLDICGIDRMARQLDNTHFLQRILTKEEIAYLRSRGASAADTLAGLYAAKEAIVKALGCGIAFPLTEIAISHTAQGQPTVALSGGAALRYPGHLLLTITHDAGVAAASALYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8F8</accession>
    <name>R7I8F8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fn3_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47761">
        <property type="protein sequence ID" value="CDE47761"/>
        <property type="gene ID" value="BN770_01343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436253" description="Fn3_like domain-containing protein" evidence="4">
        <location>
            <begin position="31"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="973"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="5">
        <location>
            <begin position="441"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109451" checksum="C86BAE5F31A4C1F3" modified="2013-07-24" version="1">MRKVRITTGLSCLMAFILCFVIFGSNLAMSYDTVVNGMLGVQTSKVINDESVEDEDTIYYKSAYGDINAKTLKVLKEETYTEAVQEQEEGTVLLYNKDNALPLSKDEQISLFGHAVVQPLYRNQSAGSRAYSTKTGVDLYKALGTLKFKVNPKLYNAYRQSKTERKTGAGTFFAENADPSALWSLGEEPISFYTDDVKSSWATGFNDVAIVMLAREGGEGVELYTQTPTEGISQLALSQDEKDLLAMIRDSGSFKKTIVLLNTGNPMEVNWVEEYDVDAVLWIGCPGEKGFIGVANILIGNANPSGKLVDTYAVSSLSAPAVVNNTFNNQQWANLTEALQKASSNASEISYYTVQTEGIYIGYKYYETRYEDQVLGRFNATGSAGSIDGVAWDYAKEVSYPFGYGLSYTTFDQKLDSVTVEDKTVTVTVTVTNTGSVPGKSVVQVYAQTPYGEYEQKNKVEKSSIQLLDYGKTALLQPGASETLTIVCDKYLLASYDYTNAKGYILSEGDYYIAIGDDAHDALNNVLAAKGATGMVDVQGNPTEGAAAKAFHFTGSFDDETYRYSATGARVTNQFEDADVNYWYPDLVTYLSRSDWQGTYPVQPVAGLPLNDEMIRILDGKIYEKPDNAPAVDAIPQGDQQGIMLITMKGLDYNDDLWETFISQMTIEEMAALIANNFGTEAVDSVGKPATPAGDGPDGIGGYTDNYSAELGKGLKTTSYPNESLLTAAFNKDLLDKRGALLGEEGLFMGLVEIWGPGCNLHRTPFGGRSFEYFSEDANLNYLAASHIVSAIEEKGVHAGPKHLTGNDQENNRQGVVNFFNEQAFREGALRGLEGGVVNGKAHSLMQAFNRLGFTGCSLSKALNTDVVRGEWGYVGHIETDAIGAVTTGYKTAFEAMMAAGTDSFCLDTQHQSSAAIAQAIRSNNDGFMLQQLRRAAKNILYNDANSSMMNGIGNNTRIVKIIPWWQPALRGVTIGVSMVTGLAVLAMLAAKLAYYKKQKGAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8H0</accession>
    <name>R7I8H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47588">
        <property type="protein sequence ID" value="CDE47588"/>
        <property type="gene ID" value="BN770_01300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435540" evidence="3">
        <location>
            <begin position="24"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="28"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="381" mass="39981" checksum="64A21ECB080448CD" modified="2013-07-24" version="1">MKKFFSLVLALAMALSMASFASAEETTTIHIGVIGPMTGAAAVYGLAVARGAEIAVEEINAAGKVNIVLDVQDDENDAEKSINAYNATLDKGTQVILGCVTTTPCIAVSAQAYDERVFMLTPSASSLEVIANKDNAYQVCFTDPAQGSAPAEYIFNKKVGEKVAIIYNNADTYSTGIYQTFESKAAELGLNIVSVTTFTNDTTDFSVQVTEAKNAGADVVFLPIYYTPASQILNAANTMGYKPVFFGVDGMDGILTMPGFDVALAEDVMLLTPFSADAPDELTKSFVGKYQEKYGEVPNQFAADAYDGIYALAAAAEKAGVKGDEAPEDICDAMIAAMQELTVTGLTGTMVWDATGAVTKTPTAVIIKDGVYVGADAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8Z2</accession>
    <name>R7I8Z2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bacterial cell division membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47971">
        <property type="protein sequence ID" value="CDE47971"/>
        <property type="gene ID" value="BN770_01461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="217" mass="23236" checksum="FB68226928209289" modified="2013-07-24" version="1">MPGVLFLLILEQPNLSTAGSILIVSLILIIMAGAKWRHILLMLVGGLGVGAFYAWSEPYRRRRLLSFRNPFSMMSDEGYQLSQSLIAFGSGGIFGMGLGMGRQKYAYLPYPESDFIFAIVGEDFGLLGCLIVVALFVALMLRGMRIAMRCPDKFGTLLAAGITSSISVQAFLNMGVVVGILPTTGLPLPFFSAGGTSISITMAAIGILLNISRESAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I918</accession>
    <name>R7I918_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase alpha/beta fold family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47017">
        <property type="protein sequence ID" value="CDE47017"/>
        <property type="gene ID" value="BN770_01111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28855" checksum="465E746706380A42" modified="2013-07-24" version="1">MEMTLQGVRVHYEIGGHGERKVVLLHGWGCSEKLMAGISDALTPDMTVLRVDFPAHGESGFPPQPWGVPDFAANLLELLMKLDFLPCSVIAHSFGGRVAIELAADHPERFEKLILTGAAGIRPKLSSEKSKKSQRYQRLKKLVGVAKKTHLFGSLPDKWQENLVQKYGSRDYAALSPEMRKTFVKVVGYDQSALLSHIKNPTLLIWGDRDTETPLWMGQQMEKEIADSGLVVLEGGTHFAYLEQATRFQTIVRQFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I939</accession>
    <name>R7I939_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000061">
        <property type="protein sequence ID" value="CDE47773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47773">
        <property type="protein sequence ID" value="CDE47773"/>
        <property type="gene ID" value="BN770_01352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="69" mass="7862" checksum="3DFB42B858729260" modified="2013-07-24" version="1">MYENEERITETEVVDGLRALLYGESLEDTQLDGSRTETYSDGGYLTHDEGFVIRTPDGSVFQITVKQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9B1</accession>
    <name>R7I9B1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47858">
        <property type="protein sequence ID" value="CDE47858"/>
        <property type="gene ID" value="BN770_01393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="177" mass="19016" checksum="A04952CD1D68292A" modified="2013-07-24" version="1">MKKFLTSKIGNILLCIAEIIVGVLLLVNPDAVTSAFVIGAGAVMILAGIVFCTLYFVGEAEKMVIKQLLFKGLLLIILGVLCVTQYGVLLAALPFVTWVYAIAMLILAAYKVQCAVDILRLSGIRWYFPAISAALAVVLALFILLNPNTAMNIVWGFMGVSIILEAGLEIATIILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9K8</accession>
    <name>R7I9K8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="8">2.4.1.129</ecNumber>
            <ecNumber evidence="7">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BN770_01468</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="8"/>
    <dbReference type="EC" id="3.4.16.4" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47978">
        <property type="protein sequence ID" value="CDE47978"/>
        <property type="gene ID" value="BN770_01468"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Transgly" evidence="19">
        <location>
            <begin position="62"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="18">
        <location>
            <begin position="343"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDE47978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="811" mass="88103" checksum="D28C90C1B089C60B" modified="2013-07-24" version="1">MKKERHWVLPAIWAILLMLLLGGAVWAYHAFSVADWQSLDPSRLTSLAQTGAIHDKNGDYVTSLVGKENRTVIDTSRLPAHVVNAFLAAEDLRFYKHPGFDITRIIGAMLTNVRDGAFSQGASTISQQLIKLSHLSSQKTIARKLEEIHLALQLEKQYTKDEILDMYLNFIYFGQGAYGVQAAAEVTFGVDAAELTPAQAASLAAAIKAPSAYSLQSAPESNRERREYILSIMLEENMLTQAEYDAAMAEELTARSAPQVQTAYGWFVDAVLDEAESRLDVSAETLLAGGYRIHTTLALRAGGYRIDPTLDPDMQRIMDEQYLTDVFPADNKDGTPVQAASAAVDTSSGAVRAIVGGRKYVTRRGLNRATQLRRQPGSALKPLAVYAPAIESAGWTCASVILDAPTAFGTYKPRNAGNAYYGNVTVRTALKNSLNIPAVKVLQAIGVQTAQRYLRSVGIELDDRDANLSLALGSMTYGASPVQMAAAYAPFANGGTYYAPYFIERITDRDGNVIYERETTGTRVLSAQSAYLMTSLLKTVISSGTGTRLSSAGTPVAGKTGTVNESGGGNRDVWMAAYTPELSTAVWMGYDEPDAAHRLPNRVSGGTNPASLARNFLRAWYTGRKKPDFTKPKGIVSADIDKKAIEWRGEPMLATSLTPSAYRLNEVFLDGTQPKKKSDVWNAPASAKSFSVSHSDDGQPLLVIQASDAAVYRVQRDAAGESFILTELRAAAGETLYYTDNRAQPGVTYTYRVIPVHAELLDNGILLEGTQSVQVARVEKPSALSRWFSGLFAPKPEEKQEEELPASIFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9N3</accession>
    <name>R7I9N3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48599">
        <property type="protein sequence ID" value="CDE48599"/>
        <property type="gene ID" value="BN770_01742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16332">
        <property type="entry name" value="Prp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007422">
        <property type="entry name" value="Peptidase_Prp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036764">
        <property type="entry name" value="Peptidase_Prp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39178">
        <property type="entry name" value="PTHR39178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04327">
        <property type="entry name" value="Peptidase_Prp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118010">
        <property type="entry name" value="SSF118010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="112" mass="11921" checksum="898947B872119655" modified="2013-07-24" version="1">MTRAVLFEDAAGRITGVSVKGHSGYAEEGSDIVCAGISTLLITIDQALCSLVGLSPIEHGGEDGFAEVLLPPGITDKQMEQAQLLFGALRIGFSAIAEQYPAYFRLTIRKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9P3</accession>
    <name>R7I9P3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48018">
        <property type="protein sequence ID" value="CDE48018"/>
        <property type="gene ID" value="BN770_01494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="217" mass="23572" checksum="DCDBA979CA24FC83" modified="2013-07-24" version="1">MNQRPNCCRPMPPQAPCPSRPPCPPNPACPSYPPTQKGVLLPRILASGREWQRRACVALYVGGLPEDANGRLQLVGVTACGDADWEIAPYQEPRPCGCRGCRPSRPAPCLLRVNIPVVCQVQAECGQVLRGESVLTTDVALPIRCVQAECWRNQMMVLPCVRLIDGGAPVCADDCRPPVFDCTIELLVEAYMTRWEACGTPAPTCPDLPLFPPPPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9R9</accession>
    <name>R7I9R9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48639">
        <property type="protein sequence ID" value="CDE48639"/>
        <property type="gene ID" value="BN770_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="310"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="342"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="492" mass="55440" checksum="8C9391D42155BB42" modified="2013-07-24" version="1">MQLKIEHLSFTYDGAPEAVFADLSLSLDTSWRTGLIARNGRGKTTLLRLLSGDLQGKGKIDCPLMPVLFPYPVADGTQTAWQIAQTAASTCEDWRLMRELSLLNVPEEALNRPFDTLSGGEQTRVMLSALFAREDAYPLIDEPTNSLDAPGRAMLADYLRRKDGFLLVSHDRAFLNRAIDHVVCLNKANTYVMQGNYDTFEARLNGENEAEAARNETLRKEIKQLEAAARKTAEWSNRAEENKRHADKSFYGKVDRGFLGAASERMMKRSKASQMRQERAIEEKQTLLKNVEQVGTLRMTTLPHPKDVLISVENGAVRYGNRTVCENVRFTLRQGERLALIGANGCGKSTILKGILGESDALTGSIRIASGVTFSSVRQRVDDLRGSLRDFIRDAQVDETLFKAILRNMDCPRELFDHDLQEMSQGQRKKILLARSLCEPAHVFVWDEPLNYIDVFSRVQLETLIRQYQPTMLLVEHDKVFVERVATGVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9V4</accession>
    <name>R7I9V4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48674">
        <property type="protein sequence ID" value="CDE48674"/>
        <property type="gene ID" value="BN770_01783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="72" mass="8523" checksum="3B414D17F31E272D" modified="2013-07-24" version="1">MERLLRFAVEHDRVIRLMFMRDGRLFQVNAHIVSYDDKQVSFVTTRSPRTQVISREELLAVDFRRGDDGQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA19</accession>
    <name>R7IA19_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GGDEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48143">
        <property type="protein sequence ID" value="CDE48143"/>
        <property type="gene ID" value="BN770_01556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="486"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="607" mass="68118" checksum="C3F7ADB295715C21" modified="2013-07-24" version="1">MKKFNIIRYLKRWWPLIALMSILAGAFFMRYASNNQAYTAQAVIKYTYDAASEGLTPNGEPLDVSEIFSSTVVKEAIERLGYSVNVDTIRSGGTVTGITPADVQTRQDALAEKGEEVEEYYPTEYTVKLTVGSSRSAEFARLMLDEILSCYFASFGEKYVDYSTIPNNAENVLAGGYDYIEQAEILSNSVDEIIAQLGNRQSAAPDFTSSRTGLSVSDLFDEYSYIQSVRIPYLFSEILGEKLTQNREILLKKYQERYANYMLTSGTDGDKVASVKEVIESYGNKNKEGSLYYAGTNGTDTNGQNGFVLGDVYEEYDANGNIKDRTTVYDTLISDYVTLLNRKSDSLIDAAYCQYIIDTFSKAPDATENTAEARASVEAEISALQTRLDDLYQVLLVTMEEYNEYMGAVNVGVLSTTAVSARVNVKLYMMLGVVVFFILGVCGAILLGRIQDFVEYLFFTEQSLEMPNRTACDLYIKNNTERVLGDDNVCVVLELTNLSHINNELGRVKGNEVLRRFADFIKEASTTCGTVYYNGGWQFIGFFEQCRREDAESFADYMHRLVHAYNEESGDAKMEYSLGMAESRTANAHTLRTLLRGAMMDRRKQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA37</accession>
    <name>R7IA37_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase family 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000082">
        <property type="protein sequence ID" value="CDE48163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48163">
        <property type="protein sequence ID" value="CDE48163"/>
        <property type="gene ID" value="BN770_01566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="98" mass="10607" checksum="2D8855085099134E" modified="2013-07-24" version="1">MTAAILKAAANHQLPDWMLTAAQESFRAIQRHFVGQMRDGTLFLAKTCYGAGLGGKTDAYRDGSYDYYISETVGSYDIKGTGAYIQAACAYEGSEPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA62</accession>
    <name>R7IA62_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fn3_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000101">
        <property type="protein sequence ID" value="CDE48371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48371">
        <property type="protein sequence ID" value="CDE48371"/>
        <property type="gene ID" value="BN770_00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="583" mass="62687" checksum="F0D5158869E38804" modified="2013-07-24" version="1">MYASVPYTDYDRQNGVEKAAVQLMDFEKTSTLQPGASQTITMKVDLANLASYDANGAKTYIVDPGDYYFAIGTDAHDALNNVLAAQGKTVADGMTADGNAAKTYKWTWTGDVDKTTFAVSKNGTAITNQLTEGDYAMDYNAFEPGTVTYLSRADWNGTFPKTYSGLTANATVSRLLNNDLYTLKTDDDVSDLVFGDTTSTLTINDMKNAPYDDPRWEELVNKVTVAEFLDFSANAFHNIQGIASVNMPQKAADDGPGGSDSHYLNEGGYQGVPYADAADYTSGTRVAPSPVNLAYTWNKELAFENGEIILGESTLVLDLPIMIGPGMNIHRHAYNARGVEYYSEDPILSGYVGSAVVQGAQSKGTLVNIKHMGFNDQEINRSGVAVFMNEQKARELELRNLQQAFEGSGKPASFEGDATKDNTYTSGARGVMTSYNRHGAVAASANVATMVNILQGEWGFHGYNVTDFTGVSLKAAPKESLMAGTTNFCGFGASVDYWNAEALSGDRAMLLAIKNDIHNALYALANSAMLNGVKSTTVVSTVEVMTPWRVAYTACEYAFGALAALSLVFWVVSKATSKGGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA83</accession>
    <name>R7IA83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000088">
        <property type="protein sequence ID" value="CDE48203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48203">
        <property type="protein sequence ID" value="CDE48203"/>
        <property type="gene ID" value="BN770_01573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="115" mass="13554" checksum="9886DDA93B510951" modified="2013-07-24" version="1">MIQLYISKKNFDAQKAERFFKERRVQVQVMDLKKHKLGERELQTMAKDVGMQGLLDREDKRAKEHPACYCNIDSVIMTAIQENPWLLKSPIVRSGQKCTIGYQPEIWENWLKADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAB1</accession>
    <name>R7IAB1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000090">
        <property type="protein sequence ID" value="CDE48223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48223">
        <property type="protein sequence ID" value="CDE48223"/>
        <property type="gene ID" value="BN770_00127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="186" mass="21287" checksum="24E412C252DE2987" modified="2013-07-24" version="1">MNVYESIPTMEKGEIRLRPVTAEDEAALLRVYGDPLALPFFNSDNCHGDIFYYDTPEKMRRAMDFWRTSWEQGWFVRWAIALRSEVIGTVELCRRGESPDDPYSGMGILRVDVGSAWEKSDVLAAVMDALLPDAYALLNCRALMTKAAPYAVARVATLTECGFMRSDKPVMGHHGERFEYYWVREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAS1</accession>
    <name>R7IAS1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48591">
        <property type="protein sequence ID" value="CDE48591"/>
        <property type="gene ID" value="BN770_01734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="67" mass="7353" checksum="95734C731764EAED" modified="2013-07-24" version="1">MASKNNNRQMVPEARQALDDMKFEIARELGVDVKGYGGDLTARENGAIGGSMTKKLIEQAQRQLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB45</accession>
    <name>R7IB45_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetylxylan esterase acyl-CoA esterase or GDSL lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000111">
        <property type="protein sequence ID" value="CDE48528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48528">
        <property type="protein sequence ID" value="CDE48528"/>
        <property type="gene ID" value="BN770_01722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040794">
        <property type="entry name" value="CE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17996">
        <property type="entry name" value="CE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CE2_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="138"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="358" mass="39901" checksum="76D098946BC92433" modified="2013-07-24" version="1">MNVQVNQNERLIRPSNPAIRYTGRIDNSNPDAPFLIYVCSQVEFRVTGHVLRVFIENIHSFYENRLGVIINGVESAVLLESGAQVIDLSDRMTDGENHVLLFKRQDCCHALVPHGFAVAEDAELLPLPPRPKRRMEVYGDSVSAGEVSEAEFACGQVDPEGHNGRYSNGYLSYSWQTARLLGAELHDIATGGMALEDGTGYFYSPDYIGMLSSWDKINYYPPFGAKTDWDFSRYTPHVVVAAIGQNDANPVNFMAQNYDCDAAKHWRSAYAGWIRAIRAKYPHAQIILTTTILGHDAAWDRAIDEVCRELSQTDGRVHHFLYSKNGCGTPGHIRGSEAAGMAKELAGFIETLPDVWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBI0</accession>
    <name>R7IBI0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease III</fullName>
            <ecNumber evidence="9">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nth</name>
        <name evidence="11" type="ORF">BN770_01397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47862">
        <property type="protein sequence ID" value="CDE47862"/>
        <property type="gene ID" value="BN770_01397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="10">
        <location>
            <begin position="39"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="211" mass="23676" checksum="2A2027236FF6F1F5" modified="2013-07-24" version="1">MTPEENKQLILAELDRLYPQPKPELHFTNPYETLVAVMLSAQCTDKQVNKVTPAVFARFPDVKSMAEADVAELYPLVKSCGFKSKASNIIAACRMILAEDGGEVPHTMEALTRLPGVGRKTANVVMSTAFHIPAIAVDTHVFRVSNRLGLVDAPDVLKTEMQLRALIPQDRWSDAHHWLIFHGRRVCKAQHPLCGECTLRPWCRKYNSETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBP6</accession>
    <name>R7IBP6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Mannonate dehydratase</fullName>
            <ecNumber evidence="5 6">4.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-mannonate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxuA</name>
        <name evidence="7" type="ORF">BN770_00145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="5 6"/>
    <dbReference type="EMBL" id="CBJB010000124">
        <property type="protein sequence ID" value="CDE48906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48906">
        <property type="protein sequence ID" value="CDE48906"/>
        <property type="gene ID" value="BN770_00145"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00106">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00695">
        <property type="entry name" value="uxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="351" mass="39476" checksum="A309EA0E3BC26EEA" modified="2013-07-24" version="1">MKSSFRWYGDSDPVTLDMIRQIPGMRSIVSAVYDVKPGEVWPEESIKHLVDECAAHGLIFDVVESIPVTEEIKLGKPERDRHIANYCESIRRCAKYGIKCVTYNFMPVFDWTRTQLDKKAADGSTSLVMYWDQMKGLDPLKDDIHLPGWDSSYTQDEVRDLIRAYGELGEEGLWQNIEYFLKRVIPVAEECGVVMALHPDDPPYPIFGLPRVITCEENIDRYLAIVDSPANTMCLCTGSLGCSPKNDIPKLVRKYSAMKRIGFMHIRNVKILPDTSFEESGHLTKNGSLDMNAIVKALVETGFDGYFRPDHGRMIWSEVGSSAKPGYGLYDRALGSAYINGLIEANGGTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBU4</accession>
    <name>R7IBU4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48743">
        <property type="protein sequence ID" value="CDE48743"/>
        <property type="gene ID" value="BN770_01802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="441" mass="51735" checksum="ADFFADAA424D09E8" modified="2013-07-24" version="1">MCNLRILKKSGSAFPLDFTGVSRYNFSVTQEVFPYMEQSMDLPQGYQIRPLTTDDLDQYNALLRYAFQVTEQELFDTGWKDEEIKQSKCPVLKRADVLGCFDRETLISQIAVYPLKANIYDSVYPIGFVTSVCTYPEYTGRGIMKRLMYQALVHMRERKQPFGMLFPYSIPLYRRFGWEIISNKISFTVKDRQIPSKAKAPGYVRRVNWENKDFMNLHTRFASSTHGCLFRNSLAWEEYWRWDEDDTVVAVYYDQHATPMGYMVYLIKDDIMHIKEMIYINREAHEGLWEYIRAHDSMIDEVRGNSYFNEPIAFEMDDGDIREMIRPYIMGRIVDVEEFLHLYHCSPEEKGVCFDLDIDDAFLPWNNRPFRVWFEGGNCTLTDRDPDYELRMSIATLSTLLIGYKTAAKLARIGRITGSDEAIARLDHALLHEAPYISDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICB1</accession>
    <name>R7ICB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48142">
        <property type="protein sequence ID" value="CDE48142"/>
        <property type="gene ID" value="BN770_01555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="443" mass="50614" checksum="01E43AC049994587" modified="2013-07-24" version="1">MKEKNRKRARSGVWSLLERMLQGVWRYRLLCLLLIIAAMVTTSALMHPGKLQSATALIALNYEEATRGLYPNQTRFNISLLKSDEVLSRALEKAGVTNMEPLALAEHISVSASSVGGMSIDSGSASAYKIATTYTVSYKRNEELPASISTGDMLQLIIEAYKEVFYENYTYVDTALNPNWDELDELEYVEIGTFFEKEIGKVSRFLKSRANENGTFRSSANNETFISLQKKTQNFSNIDLEKYNAYVRQSGLSKNRDRYVSKLKYQNQLRNIEYQKFMSHYQNHLATIDMYDSALTSVVLIPTLDTQASFYMSRTKVAIDYQASSAETENFHAHDTKEKIKDNEYTIEKMLAEDANAAENIVTAEMLIDTMKTKLADLIERTNVINREYVRYKTRNYLTVSYEQMSAMDEYSIKWSILMGGVTFCACCVLLLVIEGRKKHEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICN3</accession>
    <name>R7ICN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48242">
        <property type="protein sequence ID" value="CDE48242"/>
        <property type="gene ID" value="BN770_01592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="75" mass="8123" checksum="7422E45087525E66" modified="2013-07-24" version="1">MSGAQMAHFLKQVGNGSELEGIVTVYRTGWLVGAGQLLTVVIAAHGVFRLGKWGYEKLIDYLQERGYIVAAGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICU7</accession>
    <name>R7ICU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49450">
        <property type="protein sequence ID" value="CDE49450"/>
        <property type="gene ID" value="BN770_02025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="76" mass="8755" checksum="7C79B98B623E7C61" modified="2013-07-24" version="1">MSWLAKFNPFVMIFTSFLLVFLDRGAGEVSSKFGLNQSFADIITGVILFFIIGCEFFINYKINFCKRTGKEEKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICW1</accession>
    <name>R7ICW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo-1 4-beta-xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49724">
        <property type="protein sequence ID" value="CDE49724"/>
        <property type="gene ID" value="BN770_02105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447836" evidence="1">
        <location>
            <begin position="24"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="926" mass="101263" checksum="1359EB503335B125" modified="2013-07-24" version="1">MKRFFLLLLAAIIGLLPLMSACAEAPLDGYPGIDELPAIDTINNPFEFFDVKNDPNGDGIVTDITEWEARRTEIRDLIQHYWLGYRWETAAEDVSGKYEIVYEDNTASYGGFYGIWGTCVFNLGDEFRKLSAALLEGEVTVGDKTFGPASTKAEAKQLAIEAWNAGYSVHYIGEPPWGTEGDAVFVNTTGAITAETIPARVRPVYQAVITITNPETGAKASFAAKLNVPTDAQILAAWGEEKDQVPFVIDIGGTSAFSAANLNGQGYGLVTFKATDIYPDDSNADDGIDRAGVYTTLYPYDANDYKHASGALMAWSWAASQIVTALENQAEGTSLTLGELVRLDPAKTVITGHSRYGKAAMFTSAFDDRISICVPSECGGSGIQSYRYKVEGKIFNFNTSAYAKADRVYGKTEVPTVSYGKGNSWFPETAAMFVARDNQIPFDPVEIIALVAPRPFFTVSGIDTHWLGNEGAVASMVAAEEVYDFVGTTEIEKNNIAVRARQSDHVFYPRDFCFALAIMDREFKQTDDKLLHVKDLFPEGTGISGMSYPAADYATISELNDYPFDINSSYIPWSAESKYTLWTAQETFLTNHNVTITAHSDAPDVVLVLPDGREVAAASHEGDVFTFTLTAEQSVYGRYELRTVGTDKAAHSVYFSAVSLADALRHGTTKGDEGEENRVLGFASRLANTKENPPLVYIGSETEPASMIFTPERVVPEDTSLLEYGILFHDALFIRIANAGWDASQTFKVKNLKFVSMPEYTFEFSMADIAASAENNGKQDAALFTKPISWNAERYNNGFSQVWPAIPDTLEERQALERGETITRPEAPEKTVTAFDATVSGKAALSDTALTITLTFSEALRTGEYAVGMDIAEAWETAWNADGTQMTLTVPADALNGQHTVNLIIFRLMDTDGNLIGGPVELHLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICY6</accession>
    <name>R7ICY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bmp family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000144">
        <property type="protein sequence ID" value="CDE49500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49500">
        <property type="protein sequence ID" value="CDE49500"/>
        <property type="gene ID" value="BN770_02028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435784" evidence="2">
        <location>
            <begin position="27"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="64"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="398" mass="42796" checksum="17BFCAF3C2D491D7" modified="2013-07-24" version="1">MKKFASLLLALVVCLCCLTTAALAERAPVAKDDLKIGFIFLHDENSTYDLNFITAAKAACEKLGIAYETKTNIPEGQECYDAAAELADAGCDIIFADSFGHESYMIQAALEFPEVEFCHATGTKAHTENLPNYHNAFATIYEGRYLAGVAAGMKLNEMIEAGTITADQAKIGYVGAYPYAEVKSGYTSFFLGARSVCPSATMEVTFTYSWYDEAMEKEGAQMLIQKGCVLISQHADSMGAPTACEVAGVPNVSYNGSTVAACPNTFIVSSRINWEPYFEYILNCMMNGEDIALDWTGTIATGSVELSAINEQAAAAGTAEKLEEVKAALAAGTIKVFDTTTFTVNGEALTSYLADVDDMGDFVGDTEVVIDGEFKESFFRAAPYFDLNIDGITLPEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDE3</accession>
    <name>R7IDE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48597">
        <property type="protein sequence ID" value="CDE48597"/>
        <property type="gene ID" value="BN770_01740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="213" mass="24551" checksum="C605B47BDB0A4EEA" modified="2013-07-24" version="1">MLRTFDDIYETMPWDAVDAVVFDVGQVLLSYNPQEILDEHVPDRPDLHPILLEKIFRSPYWLMRDHGLMTRDEAIEAMIGRDEPLRPYITRVMHNWVDLKKVLPEGLKTLQSCKAHGKKVYVLSNYADDAFAVVEHKYDFFNLFDAKFVSGRLKLMKPSEQIFQYVISATGHKPSRVLFLDDTPGNVEGALFCGWQSLCVSHPGKLTEFFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDH8</accession>
    <name>R7IDH8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48632">
        <property type="protein sequence ID" value="CDE48632"/>
        <property type="gene ID" value="BN770_01756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="36"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="268" mass="29249" checksum="386C6D1CB9F069DA" modified="2013-07-24" version="1">MYCDKIALPHCQMTVYIPDLVADPAVRRPTIVIAPGGGYTHLSTRESEPIALTFAAMGMNAVIVRYRVAPAVFPAPMQDIASAVAAIRQNADNWHAEPNQIALCGFSAGAHAVGLLGVHWQEAHWWQELHLTPADVRPNALILSYPVITAGEFAHRGSFRSLTGTDDIVAHQPHSLENLVTPDTPPTFLWHTWTDGAVPVENTLLMAMALHKAGVPAEVHVFPRGGHGVALGNQVTNIPSEETRKIVPEATVWTQMAERFIRQIFTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDI7</accession>
    <name>R7IDI7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase HD sub domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000144">
        <property type="protein sequence ID" value="CDE49506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49506">
        <property type="protein sequence ID" value="CDE49506"/>
        <property type="gene ID" value="BN770_02034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="86"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="407" mass="46330" checksum="9EE9B598202A8252" modified="2013-07-24" version="1">MPRFESLSEEMTCRIESDRQHGTSSKVFCPNTSVIRRAASPRDAGSVWRPAFLHDVDKIMHCPYFNRYTDKTQVFSLIRNDDVTRRSLHVQLVSRIARTIGSALNLNLDLIEAIALGHDIGHPPFAHSGEVFLNEISMLHTGRHFSHNIHSVRVLDGIYPFNISLQTLVGIAGHNGEIELEEYCPVPVGSFTEFDRMMERAYTEDGYANRIQPSTLEGNVVRVADIIAYLGKDRQDAARVKMTAEDAYAEHEIGSLNAEIINNLVVNIIENSYGKPYIKLDTVHFEALRASKAENYKLIYNEAAKAAHLSDTVRPMMQEMYGQLLDDLRENHTTSPIFTHHIAYVTRSYYPRVKPYADCDPNQIVVDYIASMTDDYFIDLHHYLFPNSPYKVVYKGYFDGREAPAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDV3</accession>
    <name>R7IDV3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sigA</name>
        <name evidence="9" type="ORF">BN770_02135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49785">
        <property type="protein sequence ID" value="CDE49785"/>
        <property type="gene ID" value="BN770_02135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="132"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="211"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="300"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="366" mass="41625" checksum="FC26B5F8EFD5F37B" modified="2013-07-24" version="1">MTQTPDGRQKRLDDLYEYGKKKGTLTYKEIMERLMDLYIEPDQLDKVLENLEALGVTVINENDPQPAQSSEDTPLDTINLSVPDGVSSDDPVRLYLKEIGKYPLLTTEEEIALAKQIAEGTPEEQAAAKKKLSEANLRLVVSIAKRYVGRGMQFLDLIQEGNLGLIKAAEKFDYTKGYKFSTYATWWVRQAITRAIADQARTIRIPVHMVETINKLIRVNRQLAQELGRDPTPAEIAKEMGISESKVREIIKIAQEPVSLETPIGEEEDSHLGDFIEDENAPAPAEVASNAMMREQLQEVLHTLTPREEKVIRLRFGLEDGQAHTLEEVGKEFNVTRERIRQIEAKALRKIRHPGRSKKLRDYYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDX0</accession>
    <name>R7IDX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000145">
        <property type="protein sequence ID" value="CDE49528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49528">
        <property type="protein sequence ID" value="CDE49528"/>
        <property type="gene ID" value="BN770_02042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006561">
        <property type="term" value="P:proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P5CR_dimer" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="88" mass="9330" checksum="6BCC3ED430A459A9" modified="2013-07-24" version="1">MLIEAMADAAVREGIRRPDAVKMAAQAVLGSAKMVLETGKHPGQLKDEVCSPAGTTIEAVAMLEKRGFRAAVQDAMAVCAEKSRQMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE21</accession>
    <name>R7IE21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48807">
        <property type="protein sequence ID" value="CDE48807"/>
        <property type="gene ID" value="BN770_01826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435820" evidence="1">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="184" mass="19821" checksum="F32AB303A2B3A815" modified="2013-07-24" version="1">MALLCLLLMAAFYLAVIIGQPQEDETASTVTPRMDQPLLSAGQDVVTITSADDLPLLLRMFPAPALTPTTSGWPLVVGTCYDVAFENGMGRILTLTYQASDTIQVTLTSIYPARAIALLEKGDYRISASLGATLAGLRSIRMENAESIRLHAQGEEALYVMITPLLEENSLRSIAGQMTLTEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE57</accession>
    <name>R7IE57_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA and rRNA cytosine-C5-methylases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50109">
        <property type="protein sequence ID" value="CDE50109"/>
        <property type="gene ID" value="BN770_02283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="116"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="300" mass="33037" checksum="1C21927D12227A51" modified="2013-07-24" version="1">MIPEVPPLLHERLEAQYGTELAREIEAGYVRKRTTFRVNPLKGDRDAVLREIADAGIATEPIAWYDDAFLLPDGNEEQLRALPCYDAGAIYLQSLSSMLPALVLAPKAGETVLDMAAAPGGKTTQMASLSGGKALITACEKNAIRADRLQFNLTRQGARAVNIMRQDARLLDSLFKFDKILLDAPCSGSGTLLLEDGEPQRRMTADWLAKTAKTQKVLLQKALSLLPKKHEMVYSTCSVLQMENEDIVQSAVSMGICEVVPIEHPFLTDVPLLPTKVDGVVCVKPDERFEGFFVAKLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEA0</accession>
    <name>R7IEA0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_02109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49731">
        <property type="protein sequence ID" value="CDE49731"/>
        <property type="gene ID" value="BN770_02109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="224" mass="25439" checksum="B59C0D4FCC187673" modified="2013-07-24" version="1">MFTILVVEDDAPLQRMMSAFLGLNGFSVVGAANGEEALNAIDKVMPDLVIADVMMPVMDGWELTRELRRCYPRLPIMLVTARDTIEDKRTGFTSGADDYLTKPVDLDELLLHVQALLRRSQAMTSHQLTIGQTHLDYDSLTVQRGDTLLTLPKKEFFLLFKLLSSPMQIFTRRQLMDEIWGMDAQSDERTVDVHIKRLREKCEIFPDFSIVTVRGLGYKAVKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEE2</accession>
    <name>R7IEE2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na/Pi-cotransporter II-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000127">
        <property type="protein sequence ID" value="CDE48952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48952">
        <property type="protein sequence ID" value="CDE48952"/>
        <property type="gene ID" value="BN770_01882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004633">
        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="343"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="448"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE48952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="541" mass="58256" checksum="75F0AF6A65BD025C" modified="2013-07-24" version="1">MTIMNVLSLFGGLGLFLFGMQLMGEALEKAAGTRLKKLLGMVTGNRFLAMLAGITITAVVQSSSATTVMVVGFVNAGLISLTQAVGVIMGANIGTTVTSLLLSVQIDFAAIFTFLGLILSNLPDKYRTAKQFGTITMGLGILFIGMNTMSGAMEPLRTWEGFQKAMASINNPILGVLIGAGITAVLQSSAASIGILQTLVAQGLIGLDSAIFILFGQNIGTCVTALLACAGTNSTAKRAATVHLLFNVIGTVIFVIIACCLPLASWVEMLSPGNLKLQIAIVHILFNVTTTALLLPAASWLEKLACLIIKDDGSAGEAMKLVYFDARMLKTPPIAVAQLFNEVQRMGSIAMGNFQRAMECFNEWDEKKSEELARNEDVLDYLNREITDSLVEVKGLDLSEKDTKLVGSLFHVVNDMERIGDHSQNILESAQLKNQDEVKFSPKAVQELESLSNLVRAQVQRSLDMFKAQVTDNVLLGEVESVEDEIDTTTEALRSHHMDRLKNHKCSAKNGMIYLDMLTNLERIGDHAENIATSAKSATGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEW3</accession>
    <name>R7IEW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50334">
        <property type="protein sequence ID" value="CDE50334"/>
        <property type="gene ID" value="BN770_00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="469" mass="52253" checksum="42873D14928C1A49" modified="2013-07-24" version="1">MERILILMQAANWAEATEAMTSARENALHRNALSYALVLPEAPTSPEECNMAAFGALRYLVSPEMTFAAMETLWHGERYALLAHPAMRFERDWEKKLLRALNDCPVENAQAVLTGYLPAQDDPIGAVCPVAAERIDPDGTLCFAHGMPLTLAAHPMPGAFLHPDFFFARAGFIRAMAQGSGTAFLRAMVQGWQCCTLNQPVITLTHDLPVPPVRIDPQEDGLAQLKEEYGVDFAAGTLSAAAKRGMKSNSLDMTLAVTPLMRIKSAVQRRRRKRTDPMPLCVTVCPASLDEEGMHWLRQLTQMQDLALLCYAEGLKLREVAEFHPNVLEYKPRYALPMPTGKPPLFSRAAMLSAARDRVLSSTHYIWMAPDCVRYPLYTGMALPWKRLCGEKIVLASVRNRLDLSMVVVPDKQIKPLMSAIGEQLRALLAAGTIPETEEALWAGIVKEHPDWFEFRALPVEKQLFTFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFB4</accession>
    <name>R7IFB4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_02347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50285">
        <property type="protein sequence ID" value="CDE50285"/>
        <property type="gene ID" value="BN770_02347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="9"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="352" mass="37418" checksum="02DE64BAF9A7C623" modified="2013-07-24" version="1">MTQVLFPTPEALALASQLLHDGQLVAFPTETVYGLGANALDAKAVLNIFAAKGRPADNPLIVHVYDRAQLTPLCEVSPLAEKLMDAFWPGPLTLILPRKSAIPDEVAASLPTVAVRMPSHPVAAALLRACKLPIAAPSANRSGKPSPTTAHHVLVDMDGRIPLILDGGSCDVGVESTVLDVTSGAPCILRPGGITKDMLESVLGHVDVAGSVLRPLQKGEKALSPGMRYKHYSPDGQVTLVEGTEADVVAAMAKLAAHADAQGHRACVMCFTEHMDALKNCHPHDIGSRDNASEVAHRLFDTLRRLDEEHMDVIFSEVVPPEGVGLAVMNRLGRAAAFHTIQARDVLKDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFD2</accession>
    <name>R7IFD2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2179 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_02249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50048">
        <property type="protein sequence ID" value="CDE50048"/>
        <property type="gene ID" value="BN770_02249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="227"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="291" mass="31743" checksum="B0ED72327B4A7339" modified="2013-07-24" version="1">MNKQWNWKTVLQHEQIIVWTQIVLGCIIGGAAYPLFLTPCNIAPGGLTGVGMILNYLFQFPIGTTALVLNIPLFIMGYRSMGHVFVVRSLVATVLFSLAIDILQLQPLTNDPMLGAIFGGALMGVGLGLILRGGATTGGTDMLAKMVHQKLPFISTGMFLMIIDCVVVIFAAVCIGTTEALFALVCIFINGKVIDMVMLGLSRNKACFVMSDKWAEISHQVLNDMDRGATQLSARGAYSGKERPVLLCVLPPQDVARFKEIVRKEDDRAFMFITEAHEALGEGFDRLAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFF1</accession>
    <name>R7IFF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Resolvase N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50068">
        <property type="protein sequence ID" value="CDE50068"/>
        <property type="gene ID" value="BN770_02267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="186" mass="21004" checksum="3CA0861CB919DF76" modified="2013-07-24" version="1">MARIGYVRVSTVHQNTQRQEYAMPTDLDKVFTDKASGKNTDRPQFQAMLDYVREGDTVYFESFSRVSRSLPDLLNTLDYFAEKGVTFVSQKENIDTTGATGKLIVSVLGAISAYEREINAERREYGYKKALDEKRVGRPKAVANQAFHDAVKLWKDGKITATEAIKQAGMTRTTFYKLVKAERGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFI1</accession>
    <name>R7IFI1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_02270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50093">
        <property type="protein sequence ID" value="CDE50093"/>
        <property type="gene ID" value="BN770_02270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="143"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="426" mass="48751" checksum="D203967A1A2812DC" modified="2013-07-24" version="1">MLDINLLRTNPELVKENIRKKFQDEKLVMVDEVVEMDKEYRAAIQQADTLRNQIKVASKQIGMLMGKGQKEEAEKAKEQVAVYKADLEGLAAKEDELQAEIRKRMLVIPNIIDPSVPIGKDDSQNVEIERFGEPVVPDFEIPYHVDIMERLHGIDLDSARKTSGNGFYYLMGDIARLHSAILSYGRDFMIDRGFTYCIPPYMIHGDVVTGVMSFAEMENMMYKIEGEDLYLIGTSEHSMIGKFIDTILDESQLPQTLTSYSPCFRKEVGAHGIEERGVYRIHQFEKQEMIVVCKPEDSPMWFNRLWQNTVDFFRSMDIPVRTLECCSGDLADLKVKSLDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVKGDDGRKYFAHTLNNTCVAPPRMLIAFLENNLQADGRVRIPEALRMYMGGKEYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFJ1</accession>
    <name>R7IFJ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">BN770_02277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50103">
        <property type="protein sequence ID" value="CDE50103"/>
        <property type="gene ID" value="BN770_02277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="202"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="313" mass="33615" checksum="0007EE10D84469C5" modified="2013-07-24" version="1">MRIVFMGTPDFAVPSLKALVEGGYSVVGVVTQPDRPKGRGKKLAMSPVKEYAIQQGIPVLQPERISRDGYEDLLNLHPDLCVTAAFGQILSQKILDIPPLGTINVHASLLPKHRGSAPIAWAMVQGDKTTGVTTMMTARGIDNGDMLLKAETPIDPAETCGELTARLSEIGAKLLIETLKALENGTLERIPQDESQMTYDPKLEKDMGVIDWTQDAADIVHRIHGLNPWPGCTSAAPGGTWKLLRAEVADMSGQPGEVLAADGKEGLIVAAGKNAVRVRQLQVPGGKPMDARDYLRGHAMAAGTMLKEDTENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFW3</accession>
    <name>R7IFW3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="5" type="ORF">BN770_02426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50510">
        <property type="protein sequence ID" value="CDE50510"/>
        <property type="gene ID" value="BN770_02426"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="336" mass="35584" checksum="55FCF9E955098C94" modified="2013-07-24" version="1">MRIFVDATGGDLAPQAPVEGTVEALRRNPELTVTLAGIVPEIEKYLAGADDVRSRITLLDAPEVITNHESPVMGVRKKTKSATVLGMLAVRDKEADGFVSAGSTGAVLAGGMFRLGRIPGVERPALAPLMPNGKGYFLLIDCGANVDCKPEYLTQFGVMGDAYMRGVMGIEKPRVGIINIGAEDEKGNALVKDAFPMMAEAPYHFVGSVEARDLFSDIADVCVADGFAGNLVLKTMEGVAMFMLKTMKQELMADTRSKIGAALAKPALRRLKHTLDYTEVGGAPLLGVQGAVVKAHGSSNAHAFSCAIDQAIKMVNGHVVEIIEKGVAKMNSQDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG21</accession>
    <name>R7IG21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50411">
        <property type="protein sequence ID" value="CDE50411"/>
        <property type="gene ID" value="BN770_02376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007549">
        <property type="entry name" value="DUF512"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045375">
        <property type="entry name" value="Put_radical_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04459">
        <property type="entry name" value="DUF512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19238">
        <property type="entry name" value="Radical_SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ_6" evidence="2">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Radical_SAM_2" evidence="3">
        <location>
            <begin position="66"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF512" evidence="1">
        <location>
            <begin position="219"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="433" mass="48825" checksum="C0FB52674CA32BE3" modified="2013-07-24" version="1">MSTAITHVQPGSIAQRLGLVAGDKLVSIAGEPIIDQIDYQALTAQERFDMMVEDAGGQTRTVHVRKEDWEPLGLTLDQTIVSKPRPCRNHCIFCFIDQMPPGMRKTLYVKDDDWRLSLMMGNYITMTNIDDHELDRIIRRKVSPLFVSVQCTDPDMRVNLLRNPNAAKIMDNLRLLKANGIRFHAQMVLCPGWNDGEILKKSLEDLETLRPAVQSIALVPIGLTKFRDGLPYIKPYNKQMAADLIESVKPYQERFLREIGTRLVFPADEFYCLSGLPLPTDEEYEDYPQIENGVGMLRMFETDLEYAVEDLPMEETPPRRICIATGTSVAPFLRELANKHAPRGTTVEVRPIVNKFFGESVTVAGLITGQDLVAQCQDVQADEILIVRSMIRAEGDLFLDNMSVDEVRAKLPCPLKITENSGEGFWRAISGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG85</accession>
    <name>R7IG85_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50789">
        <property type="protein sequence ID" value="CDE50789"/>
        <property type="gene ID" value="BN770_00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="639"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="748" mass="84264" checksum="2B1EB19D9DE59050" modified="2013-07-24" version="1">MKQQSGSKRLSTFARYVVSYMLVLLLALSALFLYMYVYMNREVRAQVISNGINRLSRIAYQHEGYLDNMLNTAEQIGLSPYLQPFSYRDEPWRAYELMQQLVPYTVSNDFSDQMYLCFASDDYLYSSSSMMTLDMFSSLMHYEHVSGAELMRLIRQPGGLCVLPAQKVASSLLGSDQYDMTTFIIPLGMSQKSERGSMLFLLRQNTYQQLFSDAIAMNANTCILHDGAILASSGELPLSADELTSLLAGNEATMQREFVSGGVPYTLLALGNRSWGMQYVMLMPSSELTGNVWHSMGGVLMMIAALAVAGSVLSYLLARRNIRPIREISSLLPQDESRGDEWSSIQTGIQELSRRNSDLTRRLESSLPMQRHDFVLRFMKGRFDSRELAVAAAMSVRLDIDKPYYGMVLCPEQEQNDQPFTMQEEPLNRVTGVTVCSVEMAAMNNFLYVVFADTEQGLHDVANALHQICIERYGHACVAMSNAHQNFTHAPACYLEAATAYDNRFVMDDSRVLEYSFVSVNLRDILPQARKITDGINQALVLNNRALLSGKLDELLAFLKHSSMTPFAFRLIYNDVIHTLLREHAANVADSSDMKDMYDIFSLSGCQSVDDLDELLRRLCDAILQAEKPVSTEETGGIEEVAAYIREHYADPELSISAIAEAFGVSTARLSLSFKERNRVSPNEYLTILRVERSKQLLTETELSIKEIAVNVGYYDASSFIRRFKQITGVTPLQYRRSKEDTNHGNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGE5</accession>
    <name>R7IGE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000176">
        <property type="protein sequence ID" value="CDE50685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50685">
        <property type="protein sequence ID" value="CDE50685"/>
        <property type="gene ID" value="BN770_00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="325" mass="34440" checksum="D4F875604F2065DF" modified="2013-07-24" version="1">MKKHPEQNEQFEAQLRNLPDTVNQSLAGLTAGTELNNRIQMAVRDSRASRQKKSFPVRRFVSVAGVCAAAVALFVGLSPLLSSPANAPLIQSSPLGDKPTATDRTLRADLTGSDVSIGQKQSVPSYRNLWSSSSDGSTFPLIGVNGSYYRMMTSPRSVSSSLLGTSLGTIAEYTTEPSLSGTNVMLSNKAAVGTEVYGISGMSSTFVAAEVDGQMRLFQRVSFNGNALKGSETLADVMQLSGHVASIELSGVGTITDASVCADLISLLLNDATYESSGSLSAKQSLLIELDNGLVYQFTVKNDKIASCGTWSCPEFFEAFEAACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGZ1</accession>
    <name>R7IGZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49837">
        <property type="protein sequence ID" value="CDE49837"/>
        <property type="gene ID" value="BN770_02157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="198"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="287" mass="30793" checksum="6C8B2BB354EF52E5" modified="2013-07-24" version="1">MASYDLLIIGAGPAAWSCAMTARQRGLTTAVACAQSATSWLQRAERIDNYPGLPQISGKELLSRFRAQAADMGVIIIEQLARQIMPSGDIYMTLVGNDIIESRAIVLAMGAARPKLLPGEEELLGRGVSWCGTCDGMFYRGKKVAVLSAWTGGIEEAEFLAGLASEVDYYLLAQHAQPENPPYRLCEGKPQSIRHEANQLVLKTDAGEYRYDGIFIFRPAVSPDTLLPGLKTEGAFIPVDRRMATNLPRVYACGDCTGQPLQIAKAVGEGNVAAISASADLSKGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH25</accession>
    <name>R7IH25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51109">
        <property type="protein sequence ID" value="CDE51109"/>
        <property type="gene ID" value="BN770_00035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="52"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="388" mass="41459" checksum="BF910CBD1020C063" modified="2013-07-24" version="1">MILIKGGQIKPITGAEIENGELLIGDDGKIAAIGKTVDAPADAKVIDATGCLVTPGFIDAHCHIGIDEEGMRWEGNDCNEYSSPVTPEMRSIDGINPRDEAFHLALEGGVTTATTGPGSANVLGGTFVALKLDGNCIDDMIVKYPVAMKIAFGENPKGCYGQNGHKEPVTRMAVAALLREQLFKAKRYAAEVDAAEKDPTKTRPFDMQLEALLPVIRKQIPLKAHAHRADDILTALRIAREFDLDITLDHCTEGHLIVDQLVKAGKPVLVGPSLGSKSKAELREKTFETAGILDRAGLEVCIITDAPVIPLYYLPLCAGLAVKAGMKEESAWRAITINPAHVVGIADRVGSLEVGKDADIAIFEGNPLRDIQCRTKAVFVGGKQVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH53</accession>
    <name>R7IH53_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000193">
        <property type="protein sequence ID" value="CDE51134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51134">
        <property type="protein sequence ID" value="CDE51134"/>
        <property type="gene ID" value="BN770_00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="205"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE51134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="400" mass="45390" checksum="953D622E5C531258" modified="2013-07-24" version="1">MTDFVSTWNEESFLTTPVAPLGLIAMRGTEDMGDKVNKWLLKWRKYTEETLPGDMSTTPGMGREDFLVRATCPRFGNGEGKGLIKDSVRGLDLYILCDVGAYNCTYNMYGHEVPMSPDDHYMDLKRTIAAVGGKAKRITVIMPLLYGGRQHRRSARESLDCALMLQELNRMGVNNIITFDAHDPRVVNAIPEGGFESVMPSYQIFKALLKRRKDLKLDKDHLMIVSPDEGALDRNIFYASVLGVDMGMFYKRRDYTRIVNGRNPIVAHEYMGKEVNGKDVFVADDILSSGESMIEVAHRLKELGANRIFSAVTFPLFTNGLELYQKSYDEGLIDGVISTNLTYRTPELQAALWFIEADMSKYISYIIATLNHDRSLSKLLSPYDRVHNLMNRYKQEQEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHI0</accession>
    <name>R7IHI0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Elongation factor G</fullName>
            <shortName evidence="7">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fusA</name>
        <name evidence="9" type="ORF">BN770_00019</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000191">
        <property type="protein sequence ID" value="CDE51090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51090">
        <property type="protein sequence ID" value="CDE51090"/>
        <property type="gene ID" value="BN770_00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="8"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="702" mass="78819" checksum="94F353A26865093B" modified="2013-07-24" version="1">MPRSHPLERVRNIGIMAHIDAGKTTTTERILFYTGRVHRIGETHEGSATMDWMVQEQERGITITSAATTCRWRDPRDPNNKDRTYRINIIDTPGHVDFTVEVERSLRVLDGAVCVFCAKGGVEPQSETVWKQAETYHVPRMAYVNKMDITGANFFRVVDMMKERLHSNAVPIQLPIGAENDFRGIIDLVKMKAEVYYDDEGKDVREEEIPADMMELAEKYHAEMVEKVAETDEVLMEKFFEGEELTQEEIKDAIRKATINCTMNPVCCGTSYRNKGVQPLLDNIVEYMPSPLDIPAIKGTDPHDPEKEMVRHPSDSEPFSALAFKIMVDPFVGKLAFFRVYSGTLTAGSYVMNSTKQKRERMSRIMMMHANHREEVDCIYTGEIGGAVGLKDTTTGDTLCDENNQIILESMEFPDPVIEVAIEPKTKAGQDKMTMALLRLAEEDPTFKTYTNQETGQTIIAGMGELHLEIIVDRLLREFKVEATVGKPQVTYKATIRKTVKAEGRFVRQTGGHGQYGHCWVEISPNEPGKGYEFESRIVGGVIPKEFIAPIDAGIQGAAKSGYEGFELVDFKAAVVDGSYHDVDSSAQAYEIAGSMAFKAALEKANPVLMEPMMKVEIIVPEQYMGDVMGNVSSRRGRVDGMESRGPDQIIHAYVPLSEMFGYTTDLRSRTQGRGMFTMQFDHYEEVPKSVAEKVIGERAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHQ3</accession>
    <name>R7IHQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proton-coupled thiamine transporter YuaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50127">
        <property type="protein sequence ID" value="CDE50127"/>
        <property type="gene ID" value="BN770_02292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015234">
        <property type="term" value="F:thiamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012651">
        <property type="entry name" value="Thia_Transptr_ThiT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09515">
        <property type="entry name" value="Thia_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02357">
        <property type="entry name" value="ECF_ThiT_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="232" mass="24876" checksum="B1BD1FBF1F92BE9E" modified="2013-07-24" version="1">MANWFLGRALAEEAEAENAPWSFLGEGVTFWVTVAVLLVVGVAVYLVTRKKSSKKSFWTAKTMAVGAMCMALSSVLSLIKLWSMPMGGSVTPASMLPLLLFAYCYGVGPGMVLGALYGVMQFLLDGMAWAALGAIPNLLDYPIAFGLLGLAGCFRGSKAKMTAGFVLGCFGRFMASFLSGFIFYGQYAPEGVNPVWYSLTYNGSYMLVECIICIALGLLVGERLAKELKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHU5</accession>
    <name>R7IHU5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC_E_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000200">
        <property type="protein sequence ID" value="CDE51190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51190">
        <property type="protein sequence ID" value="CDE51190"/>
        <property type="gene ID" value="BN770_00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="158" mass="17713" checksum="4DD61862B7DF2D5A" modified="2013-07-24" version="1">MESSLNIQKIVKPSFAVIGIEGSTDDGEGFIPMLWSDANAHFDEVSPVASRDENGALLGIWGVMSDETRSFLPWTDGFSRGLYLAGVECSIDAEVPDGWTKWVVPGYEYLAIENRRADTFSRMVDYFRENGVKLVGAVQEFTDPKTQQEYLYFPIRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHW3</accession>
    <name>R7IHW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase PfkB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000202">
        <property type="protein sequence ID" value="CDE51205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51205">
        <property type="protein sequence ID" value="CDE51205"/>
        <property type="gene ID" value="BN770_00036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="16"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="362" mass="40957" checksum="8B1E70351359234B" modified="2013-07-24" version="1">MLHANPLLRDISCDKKFITVGEIMLRLTPPNYEKLRMANNFEASYGGSEANIALALANLGIDSTFFSVVPNNSLGKSAVRLLRSNDVHCTPMILSTPEETPSHRLGTYYLETGYGVRPSKVIYDRKHSAMAEYDFSDVDLSALLDGFDWLHLSGITPALGENCAQLTLDLLRAAKEKNMTVSFDGNFRSALWTWEQARDFCTQCLPYVDILLGIEPYHLWKDESDHSKGDWKDGVPLQPSYEEQDEVFQHFVERYPNLKCIARHVRYAHSGSENSLKAFMWYDGHTFESKLFTFTILDRVGGGDAFASGLIYAMLHDYKPMDMLNFAVASSVIKHTIHGDANITDDVKSIRNLADMNYDIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7II42</accession>
    <name>R7II42_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choloylglycine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000207">
        <property type="protein sequence ID" value="CDE51265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51265">
        <property type="protein sequence ID" value="CDE51265"/>
        <property type="gene ID" value="BN770_00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="323" mass="36064" checksum="51C8826BDF1E4F4F" modified="2013-07-24" version="1">MCTAIRLTTRDHYFGRNLDLEYSYQETVAITPRHYPFHFRHEGTNSDHFAMIGMAFVVGGMPLYYEATNEKGLSMAGLNFPASAVYHDVKPACANVASFELIPYILGQCESVQEAKTLLQRLNITRDGFSEQLPPSPLHWMIDDREGCIVVESMADGLHVYDNWSNVMTNEPPLPLQLENLAHYQALSPEEPVNRFAPTLPLKVGGRCTGAIGLPGDWSPWSRFVRAAFLTNNSVSGDSEEESVGQFFHILGGVAHPRGCAHLPHGYEITVYTSCCNADTGVYYYTTYGNQQICAVDMHKVNLDGSEVVSYELKKQQGIHYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7II91</accession>
    <name>R7II91_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50282">
        <property type="protein sequence ID" value="CDE50282"/>
        <property type="gene ID" value="BN770_02345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="196"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="347" mass="38506" checksum="F0027D59457FA1CB" modified="2013-07-24" version="1">MARIRNRRAARTSNSGASWISYSDMMAALLLVFVLILSVSLYQYFTMLETKTAELDAQKALVSQQQVTLDAQTLQLASQQVTMDKQATEIAIIQVQLDSQAKELENAYIVLSNQQAQLQQAQTDLADREAKLIILQTDLNNKEMALQAANEVLENQQAAMAAQAEQIDALIGIRPRIITALSSALSSANLSATVDHSTGDIVLDSSVLFDTGKSEIRAEGKALLDRFVPVYLNVLLRDEYSAYLGEIIIEGYTDSTGDYYNNLKLSQERALSVATYILKMPGLTTRQRDLLKSGLLTITGRGATGLIYDQYGNEDKESSRRVEFHFSLKDSEMIDQMNRLLQQTEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIQ4</accession>
    <name>R7IIQ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallophos_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50477">
        <property type="protein sequence ID" value="CDE50477"/>
        <property type="gene ID" value="BN770_02411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE50477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="233" mass="26047" checksum="3DFBA40843A9FE1E" modified="2013-07-24" version="1">MKKIAMLGDLHGNLTATLAMEKALKDYHVDEIWFLGDAVGKGPQSRETCDWVRANCTRFVGGNWDYGIGGKRFAADNYFWDQLGEERMNWLNTLPLDMDEWISGTHFRFFHGRPVTDLMLVQHDKSVLAQPFTANGKVYGGVVFADSHRPFLRTLDVGYIVNTGSVGNSMGVPKAHAVIVEGDFGSREPGVLLMSVISVPYDNEAAAEVARRDAHLPHREAYIREILTGIYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIQ8</accession>
    <name>R7IIQ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent RecD-like DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recD2</name>
        <name evidence="3" type="ORF">BN770_00050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecD family. RecD-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000213">
        <property type="protein sequence ID" value="CDE51341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51341">
        <property type="protein sequence ID" value="CDE51341"/>
        <property type="gene ID" value="BN770_00050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01488">
        <property type="entry name" value="RecD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006345">
        <property type="entry name" value="DNA_helicase_RecD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029493">
        <property type="entry name" value="RecD-like_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041451">
        <property type="entry name" value="RecD-like_SH13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14490">
        <property type="entry name" value="HHH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18335">
        <property type="entry name" value="SH3_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01448">
        <property type="entry name" value="recD_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="337"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="348"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="756" mass="84297" checksum="B8A5E4642DD663D3" modified="2013-07-24" version="1">MDQLEATVEGTVYRNAENGYSVVTVKPEQKIGLRTVTVVGTLPMLSGGEMGIFSGEWMEHPQYGRQFKCQKVELQRPTTLQGILKYLSSGIIHGVGAKTARDIVNCFGEDTLKILDEHPERLQEVPNMGKKRWKQIIEDYQQQQSTRAAMVFLQTYGVSASLALKISKVYGERTQAVIRANPYQLCDDIDGVGFKTADAIGTAIGIPPDSDGRISAALKYVLRDQAVSMGHVYLPMDELLNRCTALLRVSREMVAHQLKTMQLLRELVISGDDGDEHVYLPAYDSAEREVATRLCELMASTVPSCATDAEDSIDAFEARHHIEFSQRQREAILMALRRGLLVITGGPGTGKTTIIKCIISLLSEFGEVVLCAPTGRAAKRMTETTGHEAKTIHRLLEYGGEEGQFGRNQDTPIEGDCIIADETSMVDMMLMRSFLRAVAPGTRLILVGDADQLPSVGAGNVLGDILQSGVIPSIHLTDIFRQSETSRIVTNAHRINEGKMPLLNEKNTDFFFERQMSLQQAADTIVALTTQRLPRFLKFGDDWRSRSVREIQVLAPMKKGECGVQALNIRLQEALNPPAPGKPSITYGETIFRVGDKVMQTRNDYDMEWRRRVNLGWEDGKGVFNGDVGFVTAVDTENHALTVRFDDEKDAEYTGQQLEDLDLAYCLSVHKSQGSEFPVVILPVVYGPMMLLTRNLFYTALTRARKLVVLVGREEIIRQMVENDHIMKRYTTLSDRLRQVATMLPKVDVFGTPIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ52</accession>
    <name>R7IJ52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000245">
        <property type="protein sequence ID" value="CDE51779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51779">
        <property type="protein sequence ID" value="CDE51779"/>
        <property type="gene ID" value="BN770_00606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="283" mass="32456" checksum="05DCC7FB8C3293B8" modified="2013-07-24" version="1">MTHEQNERLLTLLSEYLCFQADAIAPADVFAFSADAHLPPEDAYRMLLSAKLGLDPDRAEDWLLIRDALPKVIRRCDPADYAQDEYLRRIAPVSGQHGHATLTQDVILPMELFVRDDFLPLDDGTCLPQLGWFDTSFRFPAVKENNLVWMTVTPNEINTIQPCVRQSHGNVLTFGLGLGYYAFHCLLKPDVRRVTVVERDPDIISLFRTLLLPHFPRPDALEIIQADAFDFAPKHLPAYDVVFTDLWHDVSDGLPLYQQMKALEVPGVKYLYWIEQTLRCYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ86</accession>
    <name>R7IJ86_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoC</name>
        <name evidence="4" type="ORF">BN770_00489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000228">
        <property type="protein sequence ID" value="CDE51546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51546">
        <property type="protein sequence ID" value="CDE51546"/>
        <property type="gene ID" value="BN770_00489"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="230" mass="24990" checksum="6B2E18601EDCCF82" modified="2013-07-24" version="1">MSLTPHDIARMLDHSTLQPFLTEDDIRRGCELALKYNTASVCARPCDVPILAEMLRGSDVKVCTVIGFPHGAHATQIKVDEARLALDQGCEELDMVINIGEMIRGNEAYVQDEIKQICDLAHSRNAIVKVILETCYLTDAQKKRCCELSEAAGADFVKTSTGYGTKGCTIDDLKLMRASVSDHVRVKGSGGIRDLDTVLAARAAGASRCGVSATEKIMAEAEARYREGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJC4</accession>
    <name>R7IJC4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51581">
        <property type="protein sequence ID" value="CDE51581"/>
        <property type="gene ID" value="BN770_00499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="135"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="348" mass="38873" checksum="9DC1160BD30BCEF2" modified="2013-07-24" version="1">MKGKMPAKLFRVDRWQRKTKIVVSIVLLVLIVVGILSTMMPTREEMLANTSEAMQQRLAEDAQSTRKRLTISYNPLFCVSYLSVSSSGRDVVSESYVGFCNQIIPANDGAMQVVGQMINYTYRMLGGGRNLMYGAKLTILLTTITVFFGLILGTLLSLGKISKFKPLSKICSGYIFFFRGTPLLIQLFVVYFTLPKIFDFSWTGLFSAYGTDATYMGSFLASCITFSLNSGAYCAEIVRAAIQSIDKGQHEAAKALGMTYWQTMSHIVIPQSIRRMIPPVCNEFVMILKDASIVFAISLQDITTIANNIRTSEGSNLVFIPALILYLIITALFTFIFNKIEKKFSVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJE3</accession>
    <name>R7IJE3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fucose_iso_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51601">
        <property type="protein sequence ID" value="CDE51601"/>
        <property type="gene ID" value="BN770_00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_C" evidence="2">
        <location>
            <begin position="347"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="494" mass="54847" checksum="9A051315E46C41D8" modified="2013-07-24" version="1">MQNIPVVKLGLVAVSRDCFPIALSEKRRAAIAEKCGQKKLDIVEIKTTVENEKDMLKAVEELKANECNAAVVFLGNFGPETPETLIAKNFDGPCMFVAAAEGDGDMINGRGDAYCGMLNCSYNLGMRHLKGYIPEYPIGTADELADKIAEFIPIARAIIGVKNLKIITFGPRPQDFFACNAPIKGLYELGVEIEENSELDLLVSYKEHAGDARIPAVCEDMAKEMGEGKYYPELCERMAQFELTLLDWAEAHKGARKYVVFADKCWPAFPSQFGFEPCYVNSRLASRGIPVACEVDIYGALSEYIGACVTGDAVTLLDINNSVPQYIYDEDIKGKFDYKLTDTFMGFHCGNTPSCKMCDNRAVKYQLIQHRLLEPAGSDPDFTRGTLEGDIAPSPITFYRLQCDSDGVVRSYIAEGEVLPVATRSFGGIGVFAINEMGRFYRHVLVQKRYPHHGAVAFDHCAKQLFEVFKYLGVQDIAWNQPKSLPYPTENPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJH5</accession>
    <name>R7IJH5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_00701</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51934">
        <property type="protein sequence ID" value="CDE51934"/>
        <property type="gene ID" value="BN770_00701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448342" evidence="11">
        <location>
            <begin position="23"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="12">
        <location>
            <begin position="47"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE51934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="481" mass="53172" checksum="79E51D504127C5B3" modified="2013-07-24" version="1">MLTFRRLICLLLALGLLTISAVAEMPNPTLDPNANPYDETHPELLEADQLYCTSAILIEQSTGEVIFEKNADLTMYPASTTKIMTVLLGILNSNPDDKVTVSYNGSAAAMRAIDSEATVISLQEGEELTMQDLLFGTLIRSGNDGAVAIAEAVAGNESTFVALMNQTAHDLGMNSTHFMNPHGLHDDNHYTTARDLATLARYAMQNDTFRTIAKTTEYKMAATNKQRSRTLTTRHRIMLPQYNKTDNRYYYAPMTGIKSGSTSLAGYCYVGSASLNGVDLISVVMYSSQYGVWTDTKKLMAYGFSQYQHVTISELYNLNPISIYTSAYEIDDPNQGQLTLLCQPQDATQAALAELSTTKKRIDYLSENLRDLVTVSYTRDFAAPVSAGEIMGTMTYVSDDGTPITFNLVASRSVARRSNMPLTYEEIVAMTQGQTGIPIVPETVIPVVVILLIPTIALFIIFRVHRRRKRREDFSDGIPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJZ7</accession>
    <name>R7IJZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51638">
        <property type="protein sequence ID" value="CDE51638"/>
        <property type="gene ID" value="BN770_00540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448038" evidence="1">
        <location>
            <begin position="24"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="459" mass="52291" checksum="A3ABAC850CD0949A" modified="2013-07-24" version="1">MKRYLALFLSLVMILCALPLAIAEDVENPYEDDGIVIYRDADGNVIDLGGMEITVCDWWSSDWHDDEPTTAAGEATYDYRTWLEETYNFKIVQRNATTWNDSPSDFTNFATTGGDENYVWILRAGAYLAPFKAGLFYDLSTLDCLNFSDEKWNGTVTGLLSKDGGIYGMRPEKAEPRKGVFFNKRLLNDAGVDPEEIYDLQAKGEWTWEAFEALCEKLTRDTDNDGVIDRYAMMSFSSHLLPAALVSNGAGFVQVDENGKYYNAAETDAFLEAMNWVMDMVSKYEMKAPEGAEWNYFESAFINGEVALQVHEDYFAGSLANMEDDYGFVFFPKGPRAETYLYAPSDNIMVIPACYDADRAWKIAFAYNLFTNPTPGYTDSDDWKNGYYQKYRDERAVDETITMMREPEHQFVWYSDMVTGYDLGSQYIWDVYAQATTPAEKAESMRGTWQAYIDEANAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK13</accession>
    <name>R7IK13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51653">
        <property type="protein sequence ID" value="CDE51653"/>
        <property type="gene ID" value="BN770_00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="52" mass="5926" checksum="DBC80B1EBB3F4A2F" modified="2013-07-24" version="1">MQRPWRLPDKLRRKYETAEALGLTEKLRDVGWAGLSAKEAGRIGGTMRGKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK51</accession>
    <name>R7IK51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51831">
        <property type="protein sequence ID" value="CDE51831"/>
        <property type="gene ID" value="BN770_00641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="207"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE51831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="382" mass="42219" checksum="268FE44A5D85C071" modified="2013-07-24" version="1">MENTPRPRRSDRYQAQAAPSAQAAQPVTQHPVQPTRGYPPQSNSQNPPPSPVQQAMQPRSAAPAWYQQQTGYYTQLPNQRPPQRPAQMPPVRQAQAPYAGMNPAYSQPPQRRTAPLPTQSAVPHRVETAPTETVPTETADPNRLPLWLTWTIVGLCIVLLGLLAAHYLMQAYLTMRAEEWETARQNTLSYYHVVEGENGNSITYQPLIERYAAEYNLRPAFVAAIIRNESSFRTDAESSVGARGLMQLMPDTAEWIAGKIGDSNYSFDHLYDAETNIRYGCWYLNYLSKLFRGDAVLVSSAYHAGQTTVTRWLSDKGISSDGVTIPVDKLPDGPTKQYAGRVTTSYGIYEALLYPNESSEAAGAADGDIMSARAVRAGVANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK71</accession>
    <name>R7IK71_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51703">
        <property type="protein sequence ID" value="CDE51703"/>
        <property type="gene ID" value="BN770_00576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="69"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="230" mass="25894" checksum="068175CA377D6E66" modified="2013-07-24" version="1">MESEQRKNAIRGAYHLTGSNNFYDGMITCSTFSGKAVCRMVWAMNRQECEDYLSKALSGIPEDFAGKMLEVPVGTGILTMPVYQTLPKADVTCLDYSPDMMGQAKEKAEKLHLTNVKFQQGDVGALPFADGEFDLVLSLNGFHAFPDKEAAYRETFRVLKPGGTFCGCFYVSGEHKRTDWMIRHVYEPTKFFTPPYETVVSLRKRLQGMYAQVDVGSLKSIAWFICRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKL6</accession>
    <name>R7IKL6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">BN770_00652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51843">
        <property type="protein sequence ID" value="CDE51843"/>
        <property type="gene ID" value="BN770_00652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="66" mass="7583" checksum="D52DC54D08F22D44" modified="2013-07-24" version="1">MKEKIHPNYGKCIVRCVCGETFETGSTKKELRVDICSKCHPFYTGKQKLVDTGGRVDRFKKRFGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL25</accession>
    <name>R7IL25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000255">
        <property type="protein sequence ID" value="CDE52023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52023">
        <property type="protein sequence ID" value="CDE52023"/>
        <property type="gene ID" value="BN770_00754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="30"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="223"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE52023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="498" mass="56039" checksum="8D755B4E3825EABF" modified="2013-07-24" version="1">MRTARKQQCSRVLRNTFGVSGFRPGQEQATDALLDGRDLLCILPTGAGKSLCWQLPALMMDELTVVISPLIVLMHDQVRHLRERGIPSVHLDSLMTPAERADALNQLTRGQAKIAFLAPERLNHPEIHALCQQRPPAMVVVDEAHCVVQWGEAFRPSYQQIGQFVASLPRRPVLCAMTATADKQLQRGIAQSLGLRHPKRIVMPVERPNLHYSVLPTVHVTDAILRALQKIPGKAVVFCRLRARTESLAELLKRAGIPAALAELLNRAGIPAAAYHAGLNREERSRVVQAYLSGRIRVVTATSAFGMGVDIPDIRLILHDHLPTNMIDYVQQSGRAGRDGETAYALLLFSPADLLRFHTRCQQIRVQHKHRPFTQYALIQREWRPYRRVLRFCLQAPCLSQGISAAFGQKSAPCGNCSACRSGAIDKEIPNIPRMTVQELYCWILQLHRDELHRRNPHQKQATNAQLREIAETMQLPDNLPGRETYFPYLHAFHTISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMJ9</accession>
    <name>R7IMJ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51842">
        <property type="protein sequence ID" value="CDE51842"/>
        <property type="gene ID" value="BN770_00651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="117" mass="12655" checksum="C260EC5A87EE7474" modified="2013-07-24" version="1">MNTDKIYAESIANQYAPKDTSKVVALRKLDAHAKRPAAIFTYTFGVAAALVLGIGMCLAMKVIGDGSTAMMVLGIVIGLVGIACMSVNYPLYKKFLAKGKQKYAYEIMQLAKEISEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I311</accession>
    <name>R7I311_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Prephenate dehydratase</fullName>
            <shortName evidence="9">PDT</shortName>
            <ecNumber evidence="3 9">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pheA</name>
        <name evidence="12" type="ORF">BN770_00804</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3 9"/>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46254">
        <property type="protein sequence ID" value="CDE46254"/>
        <property type="gene ID" value="BN770_00804"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="195"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE46254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="286" mass="30448" checksum="002DCA411557A571" modified="2013-07-24" version="1">MSGRVEVIAFPGTSGSFSGAAAQEAFPNGQCAGFPTFPEAAKAVIEGLADYALLPVENSFAGAVLPTYSLLEKLPLHIVGETMKAVRHNLLGVPGATLAGIRRIASHPQAIAQCDVFLQGMKGVQITPSENTAISARDVAAQGDPSYAAIASEEAARSFGLIVLAKNIQTSSANTTRFLILSRTETPLATPSKATVVFTVKNEVGALVRVLASFAESGLNMSRIESRPMPETPFQYFFSADFEGRMDAEHLSRAMEAARPYTCELRLLGVYPKAIPPKRENETNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I340</accession>
    <name>R7I340_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000006">
        <property type="protein sequence ID" value="CDE46289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46289">
        <property type="protein sequence ID" value="CDE46289"/>
        <property type="gene ID" value="BN770_00819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010897">
        <property type="entry name" value="Spore_II_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07454">
        <property type="entry name" value="SpoIIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02867">
        <property type="entry name" value="spore_II_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447435" evidence="2">
        <location>
            <begin position="25"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="287" mass="31709" checksum="92EED03DC7B170A3" modified="2013-07-24" version="1">MKALRRMMAGLVCAALLFGRAAGEASFDFTDGMPETSETAAPTENPAPTITLSPAFEMTVIRPAAQQHHGAILIYHTHTWEAYRQTDERYQETEKWRTKDERYNVVAVGEALTRALTAMGYTVVHDTTAFEPPKLADAYARSLTMLEQRTASGETYDLYIDLHRDAISSTSTIRRTVNIGGEDAARFMVLVGKGTTGGYHEMPDFAANLHIAELLTDKLEAQCEGLSRDVKVRTGRFNQHIAPRCVLIECGTNENTLEEVLCGIPYLAQAIAETLDALEAETMSNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3B4</accession>
    <name>R7I3B4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000011">
        <property type="protein sequence ID" value="CDE46379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46379">
        <property type="protein sequence ID" value="CDE46379"/>
        <property type="gene ID" value="BN770_00851"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="227" mass="23566" checksum="8E92A94B64D7B5F7" modified="2013-07-24" version="1">MIGLIGAMAVEVEALEKKLEGRRETQIGMDTFVSGKLFGQDAVLAVCGPGKVNAAVCTQKMITAFSPDWVLNLGVAGAGADGVRIGDLVAATAAVQHDADTSPLGDPVGMVSKVNLVELPCDETLRARLVAAAKKANLTVHEGIIATGDQFIHDGATRARIHQLFGALAVEMEGGAVAHACLLNGVKCGVLRSISDQADGHSDMDYPTFTALAAAHSQQVVENLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3J3</accession>
    <name>R7I3J3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgA</name>
        <name evidence="11" type="ORF">BN770_00777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46200">
        <property type="protein sequence ID" value="CDE46200"/>
        <property type="gene ID" value="BN770_00777"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="10">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="9">
        <location>
            <begin position="292"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE46200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="622" mass="69293" checksum="35D7E8A776EBA6D6" modified="2013-07-24" version="1">MKILFTASECVPFIKTGGLADVVGALAPVLAKQGHDVRVMLPLYAAVPKQYVDQMTHVTDFEVALGWRRQYCGIELLEKDGVKFYFVDNKFYFGRPYIYGMGGDEYERFGFFCRAALNALPLLDFQPDVIHAHDWQSGMVPALLKIQYAHLPFFANIKTMFTIHNLQYQGVFGIREVQDVLGLGDSLWTGDKLECYGCANFMKAALVYSDIITTVSPSYAEEIQTAYYGERLDGLLRARKREVFGVLNGIDMADYNPATDARIPAEYTADDLSGKAKCKAELQEKLGLTVDPNVPIIGMVGRLSSQKGLDLVDYIIGDLMSENVQLVVLGMGESRYVNLFSWAEGEFKGKVAARFAMDHALAHQIYAGCDMFLMPSQFEPCGLSQLIALRYGTVPIVRETGGLRDTVLSYNEYTGDGNGFTFFNYNANDMLNVINRAIDYYENHKDVWHTLQQRGMTGDYSWTNSSKKYMELYEGLVSGRFDHDSASNQEKASSDDDAEANPVVVPYPYEKEEPVKPKRVRRTKEQIAADKAAKEAEKAAKEAAKAAEAPVKPARKRRTKAEIEAEKAAKAAAAEVTAEAPAKPARKRRTKAEIEADKAAKEAAKADKPARKPRAKKTETQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3K9</accession>
    <name>R7I3K9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46489">
        <property type="protein sequence ID" value="CDE46489"/>
        <property type="gene ID" value="BN770_00898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SSF50044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435356" evidence="2">
        <location>
            <begin position="34"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="196"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="720"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1045" mass="112388" checksum="A0DC59BE7981BDB5" modified="2013-07-24" version="1">MKHSWHWMRTLLTLTLVLTLCGLTPAAVPDVGYAESAAEGTTAAAAYGMATADDVIVRKQPSTSANYWFRINTGFVCEILDTVVRGDTTWYKVNSTHPTPNGRTYIGYVRASFFRPLTAEETEAYLASGRVNVTATPAPAQTPALTLQPSADDALVTATPASGSDFPFDTSIMGGTTSTPLVSMITPTPTNSQVTYGTGEITASGTNFRVAPSLSAGVIGKLNSGTVVTLLTIPDTIDENHWYQIRYNGQEGYIQSNFIRVLTAAVTATPQPSVYGTVKLLYDSANLRDAPNGTTRALWQGKGSTLSVAGISQDKGGFTWYPVYYGTDNTVYYVRSDVVEYTAGSGVINTPTPTPASGSAYGYVITTAAGVNLRLSAGGEVIVQVPRNVVLTCIGAPVQTSGSSYLWYYVRYNNLAGYIRGDFVRVCDQNGNPLGEATAAPSVTATPVVYSGYVKLTKTGVNLRVSPAGRSQGQYDIGLILPIAGATVSSGRYQWFCVRTPDGKTGYVRSDCAVPCDLNGNQVTVTPTPTPTTTTSISTYGYIQITKPSTNLRRTIGGETIHQLANESVWPLIGTVITTNGVTWYPVSADGYTGFVRGDCAYKLSATQEASYLAGKGIPKETPAPTGSIQQTSYVQTTLDYVNLRQTASRDSKSVAKVRTGTVLAFNATTTAGTSTWYRVVYNSTEVWVLGSCVKVMTQAEYQEWLNKNPGAATPQPDAAKGYIVTTRDGVNIRATANGSSILTRVKKGTVLPYYTENIKAGSYTWYLIRLSNGTEGYIRSDMVSKSNNNGGALPTATPAPSSSPTTKPSATYTTLRLGSTGDAVTRLVQELINQGYYTGSVTNVYTSAVQAAVRAFQSAKGLTVDGIAGKQTQHALFGTVEPGADDYTDYNFQFYPAEKIDWYTGGIQQLWAKGASYKIYDVKTGIVWWARRWAGSSHADIEPVTAADTARLCQIYGVSNAQEIWDKNLWQRRPCLITIGNRTFACSLFGMPHNPDGDTIPDNNMTGQICMHFTNSKGHESGKVDTYHQQAIEYAWKNCPAGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3Y9</accession>
    <name>R7I3Y9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name evidence="2" type="ORF">BN770_00772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46191">
        <property type="protein sequence ID" value="CDE46191"/>
        <property type="gene ID" value="BN770_00772"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="257" mass="29171" checksum="3F08236022468C47" modified="2013-07-24" version="1">MPRSTMKVALIRHTLSPEEVVALGARLCYSRATVDSLQQRVSRDDQSEFVSRILSMGHESVLEHASFTFAMEGVSRVLLAQITRHRLASFSVQSQRYVSYEKGFGYIVPPKIEALGEDAVAEFERQMDTMHQWYTQWQEKLGTGEGGNEDARFVLPGACETRMMVTMNVRELRHFFSLRMCSRAQWEIRALATEMHRLCMEIAPALFADAGPGCLRGACPEGEKSCGKAGEIRRTRREWLDSLADEQKKQNQSTDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4G9</accession>
    <name>R7I4G9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46744">
        <property type="protein sequence ID" value="CDE46744"/>
        <property type="gene ID" value="BN770_00063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="29"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="214" mass="23999" checksum="F9457276D72877FC" modified="2013-07-24" version="1">MENKQTGAFPFIRAVTDFVFVSDAPEKADVILIPGSRHPANAIRAAELYRAGYAPYVLPSGRHGAAVDKFIGVMPEDRAAYPDDYPTEWAFLRDVLIKHGVPDSAILREDEATFTWDNARKSAAVLKAQGISARTAILCCRPFHARRALLYYQTAMPETRFLVCPAREEGVNQDDWYLTQAGRTRVMGEVRRLGDQIVPQFEELCQYSGMKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4K4</accession>
    <name>R7I4K4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma-24 subunit ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46188">
        <property type="protein sequence ID" value="CDE46188"/>
        <property type="gene ID" value="BN770_00769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014218">
        <property type="entry name" value="RNA_pol_sigma-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016371">
        <property type="entry name" value="RNA_pol_sigma-H_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002939">
        <property type="entry name" value="RNA_polymerase_sigma-H_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02859">
        <property type="entry name" value="spore_sigH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="251" mass="28504" checksum="04D41586BA6C077F" modified="2013-07-24" version="1">MEQEEPMLPEDDAFLLDFPLRQAVPGEPEQPASVPLLSSSAAHSVYEGMTDEDVVSLCRTGDSVAVEYLLNKYKNFVRSKARSYFLIGADHEDIVQEGMIGLYKAIRDFRPEKLASFRAFAELCITRQIITAIKTATRQKHIPLNSYVSLNKPLYDEESDRTLLDVCAEGHSSNPEELIISQEDLRGIHQRIDEVLSDLEQEVLAAYLDGKSYQEIADNLGRHVKSIDNALQRVKRKLERYLEDMEAQNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4R4</accession>
    <name>R7I4R4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46859">
        <property type="protein sequence ID" value="CDE46859"/>
        <property type="gene ID" value="BN770_01058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="236" mass="27394" checksum="D3E1AA4C083C53DC" modified="2013-07-24" version="1">MIRVALVEDEESSQRTLVEYLERFSQEINEKIHVSIFPDGAEIVEDYRGNYDIILMDILMRYMDGMEAASEIRKVDKEVVILFITSTPQYVMKGYTVDALDYVLKPVSYFAFSQRMQRALERMKHRTRKFISVPFQGGMRKLDISQIRYIEVVNHSLIYHLDGETLEAKGVLSELEEALTAYHFFRCNKCYLVNLEHVNGVNENCADVDGDQIQVSRPKKKAFLDALNNYINEVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4T0</accession>
    <name>R7I4T0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1653 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000028">
        <property type="protein sequence ID" value="CDE46879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46879">
        <property type="protein sequence ID" value="CDE46879"/>
        <property type="gene ID" value="BN770_01067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023387">
        <property type="entry name" value="DUF1653-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037135">
        <property type="entry name" value="DUF1653-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07866">
        <property type="entry name" value="DUF1653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1653" evidence="1">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="75" mass="8967" checksum="EC76FB0D4637BF87" modified="2013-07-24" version="1">MSETIKPGRYRHFKGKEYEVLYIATHSETREEMVVYRALYGERGVWVRPASMWNEVIERDGKTYRRFTYIGEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4T5</accession>
    <name>R7I4T5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Pyruvate kinase</fullName>
            <ecNumber evidence="6 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BN770_00792</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 15"/>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46233">
        <property type="protein sequence ID" value="CDE46233"/>
        <property type="gene ID" value="BN770_00792"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 15 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="16">
        <location>
            <begin position="5"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="18">
        <location>
            <begin position="359"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="506"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDE46233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="582" mass="63020" checksum="0E9C1D7604A88618" modified="2013-07-24" version="1">MNTPIRKTKIVCTMGPNLFEKHLIAPLMKAGMNVARFNFSHGTYETHQHYYDEVCRIRDELGLPVATMLDTKGPEIRVRSFKNGRVTLQNGQLFTLTTDEVEGDEERVSITYKELPQDIAVGSSILIDDGLIGMQVERIDGADIVCRVLNGGVVSNNKGVNIPNAHLSMPFISEKDHQDILFAIKNGYDFIAASFTRCADDIMQIRHILQENNCHTINIIAKIENMEGVENIDEILRVVDGVMVARGDLGVEVPLEDVPSLQKKLIQRGIAAGKPVITATQMLDSMIKNPRPTRAEATDVANAIYDGTSAIMLSGESAVGAYPVEAVETMVRIALRAEADMDYIRRFSRDTSASTDVTNAISHATVTSAHDLNASAIITVTKSGSTARILSRYRPACVIVGCTTEKHVWRQLALSWGTVPLMIAEESNTDDLFEHAVDAAVQNGLVHDGELVVLTAGVPLGISGTTNLMKVHVVGHLLSRGQGLHGGKVIAPLCVIRNLEKDAKDFNTGDVIVCHQTTREMFSMLRKSSAIVLEDDNPEGHGAIAGMSLDIPVIIGAKNATNILKSGAVVTVDGEKGTVSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5G4</accession>
    <name>R7I5G4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">whiA</name>
        <name evidence="8" type="ORF">BN770_00912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46503">
        <property type="protein sequence ID" value="CDE46503"/>
        <property type="gene ID" value="BN770_00912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="6">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="7">
        <location>
            <begin position="132"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="226"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="327" mass="36839" checksum="6EA15B1AB6461292" modified="2013-07-24" version="1">MSFSATVKDELCRLELGKNCCMLSELAALYRTSGSLTFHGGGRVQVQYRVENTALARRIFRLLTARMAITPRLHYVQHARLGGRRTCVLTIGDEDSQRLMLALHLIDKDENGVVSYRRTIVRHHLTRQCCRRAYLRAAFLGAGTMTSPDKDYHFEITASEPGLVRELTRVLEKAELPVHTFQRKGQTVLYLKGAQQISDCLALMGASGSVFALEDVRIRKQARGAANRAINCDEHNSEKMLNAAQQQVSAIRWYTIAHGLRELPPALQEIARLRLENVDLSLTELGAQLDPPLSKSAVNHRMRRLMLLIQQAEEADRKEAAEQKPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5H4</accession>
    <name>R7I5H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000034">
        <property type="protein sequence ID" value="CDE47129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47129">
        <property type="protein sequence ID" value="CDE47129"/>
        <property type="gene ID" value="BN770_01154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="85" mass="9418" checksum="59C474E6A68B751B" modified="2013-07-24" version="1">MTQVRAPDIATKEEVLETFTQLMRGEKSAEQMKAADALAKYHGLFAGKEDEAPRRPPEVAQAIDDAIAALSGKKRKSRKEVKPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5Q3</accession>
    <name>R7I5Q3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Caspase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46806">
        <property type="protein sequence ID" value="CDE46806"/>
        <property type="gene ID" value="BN770_01028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447534" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="CASPASE_P20" evidence="4">
        <location>
            <begin position="752"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1047" mass="113160" checksum="CAA6CC36997D2C4D" modified="2013-07-24" version="1">MKKQFRRAGALMLALLMLMTAAPALAEDAPSAADGTQIEEIIGEEPAVTEAPTAIPTEIPTEAPTNTPIPTEIPTEAPTETPIQTEIPTEEPTNTAIPTEIPTEAPTETPISTDAPTEAPTATPDEDVFVPGLATLRSGAKLYANQQLTGDADVTEVSGTVYAEARTDSKRAVRIAFYDGVIVRTAWVKTSSTEMLTDEQTAAYDAIPRKPEDDLMAAHGHLLAPIPVHPEQKETPAPTEQPTEEPTATPEVTNPPEVTDAPTDVPTEAPTDVPEVTDAPTNPPEVTDAPTEVPEITEQPTAAPEATNPPEITEHPTEAPTDEIISDYTPVPATDAPTATPAPTDANATEIPEPTISIAPDELDDLIIGRALEQPTGISASYERSGRITLKWTAVEGANAYAIYYKPAWGSEYSLLGQSSGTTYSTTTPRMGTVYYYRIQALYVVGGQQVSQGAQSMSFPYIALGDVVIADPRGKDTSTIRLNWTPVAGATHYDVAMSLHDADDYKIVRTDLTGSLCDIRDISFNETYDFLVIPKRKLNSGDVITGLPSSNRMVGSPMETPSFTGYEWTETGLKLTWDAIPGAMGYVIYRRGFHETGYHKLMVSENTATTYIDTTMKPGEVYYYFVYSFRLAQPQGWRCFSLKGDIGMGVWLPKTTGLTAVSAQENSVRISWAATEGANKYDVYISTTPGGTPKANGRVSNAYGYHNSAVLGRTYYYRVRPVRIFSNGDVSVGDWSDELAYTHQEAVGTYRALLIGNTYTGESNELPGCDNDVDGMRTMLGRMTATPYSVTVKKNIRAEEILSSISSTFGNASYNDVSLFYYSGHGANSVGADGNPTSYHAALVGTFQTYVSIARLKTELDKIPGKKVIIIDACHSGQFIARDGTMTQVSSSAFNSQVVNLFANDDQFSGDVNRTAVVLAADGSELLSEEAPAFIDRAGETNFAKSGYYVITACRSEEKSVSTGYDSNGDGKIDRYFGLFTYGLCYGNGWNLARNAAISSLNADLNKDSKVTLYEAYVYAKVMAQSHNPNQTAQIWPENSAFVLWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I611</accession>
    <name>R7I611_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="2">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47269">
        <property type="protein sequence ID" value="CDE47269"/>
        <property type="gene ID" value="BN770_01192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="95"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="331" mass="35442" checksum="935460F98BCF6ECF" modified="2013-07-24" version="1">MKRVVVGLDTSCYTTSAAAVTAEGNVIASCRKLLPVPQGQRGLRQSEAVFTHVHQLPGLIEELSAYLTDCEIVAVCASRRPRDEEASYMPVFQAGDAQGRSLAALLRVPCFATTHQRGHVEAAKVDSGVAAGDLLAVHLSGGTTEVLSLVDDRLTLLGGTLDLHAGQVVDRTGVALGLPFPAGPHLEELAVRGTARALLPVAMADGGLYCHLSGAETQVQRWISQGTMPKEDIAREVYDLLARTVSRMVTAASQQTGIRQVLIAGGVASSRLFRELVTQRTAKRQPDLRVHFGRPEYSGDNAVGVALIGARKWREQQTLKEIEYGSTDTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I698</accession>
    <name>R7I698_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000031">
        <property type="protein sequence ID" value="CDE47016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47016">
        <property type="protein sequence ID" value="CDE47016"/>
        <property type="gene ID" value="BN770_01110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="151" mass="17421" checksum="27B1B17B8695D754" modified="2013-07-24" version="1">MLFRRVRAEFSDGVIDLLPLRLYPPEKEMGFGRVYDYMIVPHGTHREVGRISLRMGESPCVYYFGHIGYHVDPPYRGNHYARRACALLRPLIALHGKSSVVITTDPDNWASRKTCLGLGCTLERTVAVPQEIRDRWEISAVKCRYIWRIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6H6</accession>
    <name>R7I6H6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47469">
        <property type="protein sequence ID" value="CDE47469"/>
        <property type="gene ID" value="BN770_01270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="77"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="183" mass="20715" checksum="A6449C228AC0576E" modified="2013-07-24" version="1">MPSQIYEILSLMMRYWFAALGVLIVLRAFWWLWKDHRSREKKRRSLPDAGSIGEFVVESDCAALPQDTLLPVPADGTLGSVRSCDIVVPARGVSPRHLDVMFRNGYGLYIIPWRGCSCIVDGETVASRKDGMAHPLQHNSILEVGQARLRLRVFAGLDVEDVRAYAERREDGDDEQENPQYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6N3</accession>
    <name>R7I6N3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47146">
        <property type="protein sequence ID" value="CDE47146"/>
        <property type="gene ID" value="BN770_00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="69" mass="7924" checksum="929699B2B8040B11" modified="2013-07-24" version="1">MAEQVLVQVRVDKKLKEEVSEIYEMLGLDLPTAIRMFLVRSKLERGLPFKAVLPEETVPPAEMVEILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Q5</accession>
    <name>R7I6Q5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46212">
        <property type="protein sequence ID" value="CDE46212"/>
        <property type="gene ID" value="BN770_00786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="361" mass="39971" checksum="91904847D561DE73" modified="2013-07-24" version="1">MWIDAENGSVYTPRMEGGMPRVNIYDISRHAGVSIATVSRVLNNSPHVSEETRRKVMKVIDGCGYVPNAFARGLGLNTMKTIGLLCPDAADPYLARALACLEHAFRQKHYDCLLSCTNRDLAARRQGVELLTSRHVDGMVLMGSTFIEENSEDNAYIRQAATNVPVVLLNGSFQCPNVFCVLCDDERAMKEAMNQLLDSGCKRVLYLYHSSNNSGQRKLAGCRDALAAHNLPVDETLMRRFDADKFSIHAVRDCLMELERDGLQFDAVLASEDVLAVGAMKYAQAVGRRVPENLSVVGYNNSNLCLCTEPELTSVDNRLPAICERIVETMLGVLEGREMPEKTVFTAEIIQRGSTRASQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7A1</accession>
    <name>R7I7A1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumarate hydratase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000012">
        <property type="protein sequence ID" value="CDE46397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46397">
        <property type="protein sequence ID" value="CDE46397"/>
        <property type="gene ID" value="BN770_00855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="89" mass="9388" checksum="E58E983D3F6579C6" modified="2013-07-24" version="1">MIGKGSRSPAVMAAMQEYPAVYFAAVGGAAALMAECVTSLEVICWDDLGPESVKRLTLKDLPLVVAADCYGQDAFTLGQKAYLEGQNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7D7</accession>
    <name>R7I7D7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">BN770_01246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47401">
        <property type="protein sequence ID" value="CDE47401"/>
        <property type="gene ID" value="BN770_01246"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023273099" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023273097" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="187"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE47401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="404" mass="42003" checksum="A8CB115106A7D05E" modified="2013-07-24" version="1">MEHISGGVCAAKGFQAGGIHCGIRKNRGKRDISMIISEVPASAAAVYTSNLVKGAPIYVTQRNLAGGIAQLAVCNSGNANTCNADGEEVAWQMCELAGKAAGIDPHHVIVASTGVIGQPLSIEPIAQHMSELYAAVKGNGSQEAAEGIMTTDTRLKEVAVSFVVDGKVCHLGGIAKGSGMIHPNLATMLVFLTCDAAISPAMLRKALSDNVKDTFNMVSVDGDTSTNDMVSIMANGLAGNALIDSENVDYAVFCAALNEVTTALCRMIAKDGEGASRLLTCVVTGGKTVRDAKLAAKSVICSSLLKAAIFGADANWGRVLCALGYSGAEIDVKKVDVAFRSAVGSIDVCKNGASIDFSEEKAKEILLEDEVDVVVTLHDGDASATAWGCDLTYDYVKINGDYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7G4</accession>
    <name>R7I7G4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000061">
        <property type="protein sequence ID" value="CDE47774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47774">
        <property type="protein sequence ID" value="CDE47774"/>
        <property type="gene ID" value="BN770_01353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="99" mass="12158" checksum="31765A1414CEAC8F" modified="2013-07-24" version="1">MENRYWNQNGAAQAHYDEMEAAGFEYTQATYRSMHSYYRYFNDGDLPGWARSRWELTEHTSYYPFRKLNEAGEEEQERRVTERIEIEYRRFLKAQRNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7J0</accession>
    <name>R7I7J0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47600">
        <property type="protein sequence ID" value="CDE47600"/>
        <property type="gene ID" value="BN770_01308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447610" evidence="1">
        <location>
            <begin position="25"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="374" mass="43273" checksum="1746C18A235FD797" modified="2013-07-24" version="1">MKRILALAYLGFMLFSLSSTAENAISINILGNEQEDARFYFLECREEILNETKYKISYKSANITVEDLSLLTNREYDAVLLYQKVLQAAVERDLLLPINDTALNHDWTALAVYLSKDDVMYGLPYYYIANLFSLDDTLAYRANFLFPQSAGYSLETLLCACNQSDLSQTEDICLMYTNLKTPLFLMQYLSAQYNETGDLQFDTAVFRRTISCYAEMVRKGYIMDYDNAQRVKPILRLTPNPDHYVPFPNLDGMNCIVVDLYALCIPKSTEYPQKAQNFLSDFADEVCQSQIALGNWSQMVYQSPEIYGNEIRDKFPFYSENLRQEIMNDGVPRFPNTEFIRYLNQTGIITNYVNQEMTIDELIAALQQKWDEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7X2</accession>
    <name>R7I7X2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000054">
        <property type="protein sequence ID" value="CDE47601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47601">
        <property type="protein sequence ID" value="CDE47601"/>
        <property type="gene ID" value="BN770_01309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435514" evidence="1">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="171"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="288" mass="30293" checksum="EAE8A31901DD4B98" modified="2013-07-24" version="1">MKKFAAILLSLVLTLTVALADSIYVVSREDGSGTRAAFIELTGVEQKDADGNKVDMTTVEAAVYSGTSEVKTTVSQDIAAIGYISLGSMDASVKALKVARNPEDGAEAVYVEATPENVASGDYAIARPFNIAYKADNLSATAQDFINWILSAEGQAIVTAQKYVAKEPAEYQAAPVAGKIVIGGSSSVGPLMQKLEEAYEALHPEVDIEVQISDSSTGMRGAADGSFDIGMASREVKASELEAGLTPVTICMDGIAVIVNNDNAVEGLTLAQIRDIFTGEIVDWDEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7I806</accession>
    <name>R7I806_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cysteine synthase</fullName>
            <ecNumber evidence="5 10">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BN770_00088</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 10"/>
    <dbReference type="EMBL" id="CBJB010000046">
        <property type="protein sequence ID" value="CDE47413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47413">
        <property type="protein sequence ID" value="CDE47413"/>
        <property type="gene ID" value="BN770_00088"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="11">
        <location>
            <begin position="8"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE47413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="311" mass="32483" checksum="BB4E46A9E9E9A007" modified="2013-07-24" version="1">MRIAKSVAELIGRTPMLELTHFEQTHCLNAHLLAKVESFNPGGSVKDRIALGMVEAAEKAGKLLPGGTIIEPTSGNTGIGLAMVAAARGYTAIIVMPDSMSVERRQLMLAYGAKLVLTPGKLGMKGAVDKANELAAETPNAIVVGQFVNPANPATHRATTGPEIWADTDGQVDVLVAGIGTGGTLTGIGSYLREKNPNVRIVAVEPFSSPLLSKGVAGPHGLMGIGANFVPDVLSRDLIDEIITVKEDDAYRTGRELAAHEGVLAGITSGAAVWAASQVAARPEFAGKNIVVILPDTGERYLSTKMFAINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I810</accession>
    <name>R7I810_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000055">
        <property type="protein sequence ID" value="CDE47641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47641">
        <property type="protein sequence ID" value="CDE47641"/>
        <property type="gene ID" value="BN770_01321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447628" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1392" mass="149778" checksum="F37BB4F903749B90" modified="2013-07-24" version="1">MKRRLCLVLFLLMLVTCVTASGEAADWNYDANYGILRGYNGAGGDVVVPGELDGFTVDVIGVSVFRGETITSLTLPETVLELRSNAISTCDNLTRVSLPQSLVVINRMNFFSCTALTEVTIPAGVRYIGDTSFRYCDSLRKITFEGVCPAIDIDCFSLLPEGATAYVPDDQLDAYIAAFENAGSEVSVQPSGKNAVIVENNGYVESEFDFDASTGTITSYNGYATYLAIPETIGGAPVKAIGPEAFAQHTYLALLELPEGLETIGDRAFYNCETLARVHFPSTLKFIGDSAFYNAYKSSVLELPEGLEHIGAYAFYFAGIKGFLTLPEGLKTIGESAFESCSNMGGNLYLPSTLESIGSRAFKGDYNIQYIVLESLTAPTLGEDVFAGCDYLYDIDLNAHGTRQEMQQWQAYVDALGLPCRVWRAQDPTAQSPEKGAYRYENRVLTEYTGTRTRIHPHLTVSKEAVVGLGDGVFKGSQTIEYFSVAHNDEFTTIGAEAFMNSSLRNVDLFDSVTTIGARAFAGCTQLEALTLPDSLTTIGEGALDGLTGLKKLVIQCDPAIIPAGVFANLPALSDVTVEFGAIPAHMFEGSGVTVLTLGAGVTEIGDSAFANTALTTAEMQNVTAIGAGAFANTALTSAEIQNVTAIGAGAFEGSALERVRLNAAASVGERAFANTKLTKMVIPTAGSFPLSAVEGTSVELRLPADATDEQLAAWNETLQRPWYDPMLREGEVSKFVKMPFEPTPAENFEFDPDTGLIAAYIGTDVDVVVPREINGVTVVGFKNYNAFDACHDYTDSSVTSDRTEWVRLRTLVLPETIKELPDMMLAYCQQLETFVCYAPLESTGGNQFMLCRSLNNVIFVNGVREIDNYAFDSAGPLGNLYFGEHLIRIGQQAFNFAGLSSFVADAERVEYGAFTECKNLTSLHFTSKMKDFGENCIINCPNLAEICFDGCDLTASPMGLMMNVAPKLTVRVPEDMSEENIKHAQNCQSWSENRSEVTVITEPCAHAQPTLPDLPALLPTLKLDASVETAAPAQPGTFVAAEPEVAPEPTPIPEPVAQNAGIPDEYLGVWYGVRMEIGGTPYPLADMGLDVTFTLGADGAAEMNTNGDVDSIHCAMQDGMLMADGISFTLQDALLTVSMDDVTMAFSREKPQASSAAVPSINESAIIDDFRGFWTLARVTADGITLPAEAAEMAGDTLVIYGTVCDLTLHGTTLDGLSCRMDNFTLLISILNGEAAVTLREDGTLSLEMSDLTLWYERTGDAPEAAAEPTAEFNPAVTPEPAAGAEIMLEKKYVMTDADVSGYNMTAAQLGNYEYSLLFHEDGTVKLVIAGADIPGLTWVFGKVPTEAGEVDGIVINYYTQALYIVPTEKGCDMDYFGSMLIHFAPEESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I861</accession>
    <name>R7I861_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="7" type="ORF">BN770_00998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46697">
        <property type="protein sequence ID" value="CDE46697"/>
        <property type="gene ID" value="BN770_00998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE46697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="241" mass="27406" checksum="377FBFECB499168C" modified="2013-07-24" version="1">MAVISMKQLLEAGVHFGHQTRRWNPKMAQYIFTERNGIYIIDLQKTVRKIDEAYAFVRDTAMQGKTILFVGTKKQAQESIESEAKRCNMYYVNNRWLGGMLTNFRTIQTRIRRLNDIDKMEQSGQFDLLPKKEVIQLKAEREKLEQNIGGIREMKKLPGALFVVDPRKEHIAVTEARILNIPIVAIVDTNCDPDEIDYVIPGNDDAIRAVKLIAGKMADAVLEGKQGEQSAEEAPVEKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8L2</accession>
    <name>R7I8L2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">engB</name>
        <name evidence="10" type="ORF">BN770_01450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47950">
        <property type="protein sequence ID" value="CDE47950"/>
        <property type="gene ID" value="BN770_01450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="201" mass="22706" checksum="803E37AC364FAE05" modified="2013-07-24" version="1">MEIKKAEFITSMAQYGKFEGVGLPQIAVAGKSNVGKSSLINKLCNRRSLARTSQTPGKTRLINAFLLNDSFHLIDLPGYGFAKVDKQEKLRWGKMMQDYFEQSDELRHVLCLVDIRHEPTEDDKQMNLFLRQMGIPFTVIATKADKISRGARQKQLAPICRALLVQPWEVICWSSEDGTGRDQLLTLLEKVLAPEEEAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8M0</accession>
    <name>R7I8M0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="19" type="ORF">BN770_00123</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000090">
        <property type="protein sequence ID" value="CDE48219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48219">
        <property type="protein sequence ID" value="CDE48219"/>
        <property type="gene ID" value="BN770_00123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="29"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="433"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="619"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDE48219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="675" mass="76315" checksum="2A8E8A1B32846CA6" modified="2013-07-24" version="1">MDETRGKFVLKAPYQPSGDQPQAIEALTKGVNAGMKGQVLLGVTGSGKTFTMASVIAQVQRPTLVIAHNKTLAAQLCSEFRAFFPDSAVEYFVSYYDYYQPEAYIASSDTYIEKDAAINEEIDRLRHSATAALRERRDVIIVASVSCIYSMGDPSEYEGQMVSLRPGMAIGRDDLIRQLIAIQYDRNDVEFERGTFRVRGDVLEIIPAGGKEHGLRIEFFGDEIESISEFEVVSGHTLASLEHASVYPATHYATDQTNLPEKIAVIERDLKEQVDKFTKEGKLLEAERIAQRTNYDIEMMREIGYCSGIENYSRYFDGRKPGDAPYSLLDYFPKGFLCFIDESHVTVPQIRAMYNGDRARKEQLVEYGFRLPSAFDNRPLLFEEFEQRIGQTIFVSATPGPYEISHASQIVEQIIRPTGLLDPKIILRKATGQVDDLVGEIHQVVAKKQRVLVTTLTKRMAESLTEYLQSMDIRVRYLHSDVTTMDRMALIRGLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSETSLVQTIGRAARNVDGRVIMYADVMTDSLMRAISETNRRRAIQEEYNRVHGITPESVRNAVHQVLEITKKAEESAPAAMSEDERNALMKQVEDQMLSAAKALDFEQAAKLRDQLLELKGEKPQAEQIQKKRRRTRESTRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8M2</accession>
    <name>R7I8M2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15 16">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="6 15 16">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">murD</name>
        <name evidence="19" type="ORF">BN770_01460</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15 16">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="6 15 16"/>
    <dbReference type="EMBL" id="CBJB010000075">
        <property type="protein sequence ID" value="CDE47960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47960">
        <property type="protein sequence ID" value="CDE47960"/>
        <property type="gene ID" value="BN770_01460"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 15 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 15 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 15 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="18">
        <location>
            <begin position="117"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="17">
        <location>
            <begin position="315"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="119"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDE47960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="457" mass="49846" checksum="C723BF494AA55F90" modified="2013-07-24" version="1">MRNTEKYAGKRVLVVGMARSGIAAAQLLCKAGAHVIINDSKAAEQLGDSLKPLENLPLERRLGCPAMECLDGIDAMVISPVVPDNAPFVLKAKEMGVYVTGELEMAYQLSSGEMVAITGTNGKTTTVTLLGEIFRNAGHTTHVVGNIGYPYSAAGIDSQDGDLFVCEVSSFQMETAETFHPKAAALLNITEDHLNRHGTMEVYTAMKMRQFQNMTAEDVAVFNADDPALAPLIGQVKAQVMLFSRKRAVEQGAFVRDGEIVVRFHGAEETICPAKDVFIPGPHNLENALAACCIAVAMGVKPDVIAHTLRTFQGVEHRIEFVRELDGVRYINDSKGTNVDSTIKAIQTMTRPTAIILGGYDKHCDFTPMVQEMLASPYIKEAVLIGATADQIERTCRENGYTHLHRAGTLKDAIDQCRALSSDGWNVLLSPACASFDMFSDYESRGRIFKELVRELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8X1</accession>
    <name>R7I8X1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46967">
        <property type="protein sequence ID" value="CDE46967"/>
        <property type="gene ID" value="BN770_01092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="42" mass="4953" checksum="74EDEE954E7695DB" modified="2013-07-24" version="1">MKKLIQKAVKVLAFLLVLALCYGLMDQVLKRKKRCQHKARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8X4</accession>
    <name>R7I8X4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000095">
        <property type="protein sequence ID" value="CDE48309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48309">
        <property type="protein sequence ID" value="CDE48309"/>
        <property type="gene ID" value="BN770_01636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="175"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="397" mass="44053" checksum="EA44225E4EF4AA90" modified="2013-07-24" version="1">MKRLLKRLSLQWRITLLTILLLATACVTMKTLLCSSGHAYMDSIGNYVMHYVQEDPQAIRVDIPDEQWKDLSERFNGEFVLELSGAKHSFCIRGWYIALAVTALGGAVAYFVSGKALKPLKRFTAKAERVQLQSLTEITLSEDEAVEFSRLSRAINQMLLRLNQAFDAQQQFVGNAAHELRTPLALMQARLDLYMATDHGDNRPETAETISMLREQTERLSKMVRTLLDMSDLKAVPRTDKIQLAPMIEEVLADLSPLAEKSGVALSQSGEDLWITGSDVLVYRSIFNLVENGVKYNHPGGSVRVAASRRGSSAVIEVRDTGCGIPENFRESVFQPFFRVDKSRSREKGGVGLGLSLVWEIAHLHGGSVRITESGKDGTVIELTLPISAEEQDIPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I938</accession>
    <name>R7I938_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE48016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48016">
        <property type="protein sequence ID" value="CDE48016"/>
        <property type="gene ID" value="BN770_01493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015268">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="349" mass="40884" checksum="1D661AD557077B9A" modified="2013-07-24" version="1">MAVQKKKELALRSSAAEYLTFVAATGESDVSFEMRYEDENIWLTQKMMATLYDAGLSTINEHIKKIYADGELTEAATIRKFRIVQTEGSRQVSREVAHFNLQMIIAVGFKVNNQRAVQFRKWAGQIVKDHTIQGWTMDVERLKKGHMFTDEYFERQLEQIREIRLSERKFYQKVTDLYATAFDYDKDAKTTRLFFQTVQNKMHFAVHRHTAAELIVERADASKEHMGLTTWENAPNGKILKTDVTVAKNYLSEQEMHYLERIVSLYLDYAELQAERKIPMSMEDWAKRLDGFLDFNGNELLTGPGKISAEQAKLHAETEYEKYRIIQDRLYESDFDRFLMLEQEVNHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I981</accession>
    <name>R7I981_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000032">
        <property type="protein sequence ID" value="CDE47077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47077">
        <property type="protein sequence ID" value="CDE47077"/>
        <property type="gene ID" value="BN770_01133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="63"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="420"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="862" mass="96708" checksum="BF20768BA9F8338A" modified="2013-07-24" version="1">MNQYQQDHGNAPEQVKGRFLVFVIILILMFAYLFVGLVNLQLKSSEGYSTKTESTRLKTIPLTGKRGNITDANSVILATDEMVYNVTFYKDASESSSSVYKTYTQSIIDTLKIIERNGGKLAFSYVIQRSEETGEWEFNFGSGVSDATLQTRESQWRSNNYVTAKSYPTPEDCLVTLKHRYRMVNSAEEEEEVRAAYIEKRGDDSGYVPCIIVDEDTMLKVMAVFSEMQMNLYNSLPITIAKNVPFETVTEIETKSMMLPGMDISESTQRVYPKQTLAAQVIGYIGKIPSRTMWLTLQAKGYSYNDTIGRDGIESSMEDWLTQNSSLRKGSRVVERNNWSKIVREISYTEPSDGNNVKLTLDVNYQTVAERAIASNVARIRDKQEDLMVSSKWLEDNRTLIATYDWEHYPLELAEHGVMLVLDMQARVLAMANYPTYDLNALVAGGDEARAILSDDRNLMLNYAIGSRATPGSIFKMVTGFGALDSGVLKPDEMISDMGYYTAYNSDLSTAPKCWISEGYRSQHYYQTIVGGLEHSCNYFFYECGSRLGETRLYQYAAAFGLTSKTGIDLPGEVRSVVGSQNTLYDPTKPVGESSQDTSRPIIVFNSIKSHLKKCGESRGMEYDDERLSSCAKRLMDMAVAYPESSWVENMRTILMEELNMPRSMVYSNSVITDTYNYINDIKWGGSQTILTAIGQSVTTVTPIAVARYVTAVANGGKVYNVSIVDSIISPEGEVLSRRDPVLINDLNDTNGYFNLIHKGMKGVTDDTGTAKRYWSDFKWQKKMGAKTGTAQVNQIDLENNGWFVCFAPLDNPKVAIVVYVPHGYSGAMCSYAAKDFLNWIFPEWDKSDVDYDLPIGNSLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9B2</accession>
    <name>R7I9B2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EDD domain protein DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48469">
        <property type="protein sequence ID" value="CDE48469"/>
        <property type="gene ID" value="BN770_01707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="280" mass="30066" checksum="A11934534D0EC3CF" modified="2013-07-24" version="1">MTTKIVADSSADLLTLGDLPFASVPLTIHAGDRVFVDDEHCDIDGMIAFLRTYKEKTTTSCPNTECWLKAFGDADTVYCVTISSAMSGTYNAAMLAAKEYMELHPERRVHVFDSLSAGPGCTQMVEKVADCVRKGLSFEDTVAAVTAFRDRANLIFSLASVHNFVANGRVSAAVGAIVGILGIRVIGKAGVKGELVIASKSRGDHKAMQNMLSAMMKQGWNGSKVYIHHCMNQSAAEELKAALLEKFPNAEIEIGVLRGLCSYYAEVGGVLAAYEGNLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9F6</accession>
    <name>R7I9F6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="5">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="5">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="5">UPRTase</shortName>
                <ecNumber evidence="5">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrR</name>
        <name evidence="7" type="ORF">BN770_00084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer and homohexamer; in equilibrium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000035">
        <property type="protein sequence ID" value="CDE47147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47147">
        <property type="protein sequence ID" value="CDE47147"/>
        <property type="gene ID" value="BN770_00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 5" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="6">
        <location>
            <begin position="13"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="5">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="188" mass="20928" checksum="454CD33C3F246410" modified="2013-07-24" version="1">MMNMQAGIPKAQLMAGDAMNRALTRMAHEMMEQLMPLENVVLVGIRRRGVPLAQRLSDIIEKYEHVRIPVGEVDIAMYRDDRDPAQLNVEVQEKHLPVDVTGKVVVLVDDVLHTGRTVRAAMDAILDQGRAARICLAVLIDRGHRELPIRADFVGKNVPTSNNEQIGVQMEEIDGGDGVALYDGRMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9M2</accession>
    <name>R7I9M2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YodJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48589">
        <property type="protein sequence ID" value="CDE48589"/>
        <property type="gene ID" value="BN770_01732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436301" evidence="1">
        <location>
            <begin position="26"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="2">
        <location>
            <begin position="64"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="239" mass="26902" checksum="F62B61C131BDDB06" modified="2013-07-24" version="1">MASLLETLAALATAGTMMISSSLDAAAPQNDVDGFLFLQNRQWLASRAYEPETVIADVPGQIRQMRQEAALALEEMFDACKKDIGITLKAVSGYRSYARQETIYNNKLERVHGSVEKADEYVARPGASEHQTGLVMDVGQKSDKVNLTGGFGATKGGKWVAEHCWEYGFIIRYQKGWEEITGYEYEPWHVRYVGKENARRIHEQEMPLEEYLQIVRNERLLGIVEGTYLGEVEVEESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9Q7</accession>
    <name>R7I9Q7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate carboxykinase [ATP]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000089">
        <property type="protein sequence ID" value="CDE48216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48216">
        <property type="protein sequence ID" value="CDE48216"/>
        <property type="gene ID" value="BN770_01582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436304" evidence="1">
        <location>
            <begin position="20"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="331" mass="36218" checksum="C9080243DDB15479" modified="2013-07-24" version="1">MKKGMFSMMNYFLPLKGMASMHCSANTDKEGKNTAIFFGLSGTGKTTLSTDPKRLLIGDDEHGWDDNGVFNFEGGCYAKVINLDKDSEPDIYNAITRDALLENVTLDKDGKIDFADKSVTENTRVSYPINHIKNIVRPVSAAPAAKNVIFLSADAFGVLPPVSILTPEQTQYYFLSGFTAKLAGTERGITEPTPTFSACFGQAFLELHPTKYGEELVKKMKANGAKAYLVNTGWNGTGKRITIKDTRGIIDAILSGDILKAPTKKIPYFDFEVPTELPGVDSKILDPRDTYADASEWENKAKDLASRFEKNFVKYTGNDAGKALVEAGPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9W8</accession>
    <name>R7I9W8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48251">
        <property type="protein sequence ID" value="CDE48251"/>
        <property type="gene ID" value="BN770_01598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="154" mass="18025" checksum="42D6E0426ACEAABB" modified="2013-07-24" version="1">MSFMDGSVGWADAGVLIPYRFWKLYGDDSLIRRHYGGMVRYARFMIKRCTQFTPLRHHLPLKGEAKKYIVNYGHSYGEWAEPADVFPDDWKNIVLPHPEESTPYTVFIMEHMMEIAGYLGKQQDKALFEKYRDGCTKAYRELVTLPGYTLDTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA78</accession>
    <name>R7IA78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000046">
        <property type="protein sequence ID" value="CDE47422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47422">
        <property type="protein sequence ID" value="CDE47422"/>
        <property type="gene ID" value="BN770_00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="332"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="589" mass="64628" checksum="3E799DA9CE7770DA" modified="2013-07-24" version="1">MLKTLAAQIKQYKKSTILTPIFAALEVVMEVLIPMAMARLVKYGIEGGDTGAIYRYGFLMMAMAMLSLVFGSVCAHTASHASTGFAANLRDGMYRNIQRFSFANIDKYSTAGLVTRMTTDVTNVQNAFQMITRIAVRSPLTLIFSMIVAFVINPELAGVFLIPLVLLGVVLGLIIKRATHLFDQVFKKYDDLNASVQENVSGIRVVKAFVREDFEDKKFGKAATNVYNLFVKAERIIAFNSPVMMLTIYGSVMALSWLGASLVTGGSLDVGDLTAMFTYVMNMLMNLMMLSMIFVMLTMSAASARRIVEVLNEEPSLSNPEQPLETVKDGSIDFNHVMFKYHADGNGDPILNDIDLHIKSGETVGIIGGTGCGKSTLVSLISRLYDATEGSVEVGGVDVRKYDMEALRNQVAVVLQKNVLFSGSILENLRWGNENATLEECKEVCAQACADEFIDRMPDGYDTHIEQGGTNVSGGQKQRLCIARALLKKPRVLILDDSTSAVDTATDAKIRRAFAQRIPGTTKIIIAQRISSVQDADRIIVMDNGRVEAFDTHENLLKKSDLYREIYETQTSGGGDFDSPDQMKGGDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA82</accession>
    <name>R7IA82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000046">
        <property type="protein sequence ID" value="CDE47427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47427">
        <property type="protein sequence ID" value="CDE47427"/>
        <property type="gene ID" value="BN770_00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="462" mass="50070" checksum="1FBE5F4853348105" modified="2013-07-24" version="1">MAQKNVTRDMTQGSPLKLILTFSLPLLGGFLFQQLYSFMDTMVVGGVLGTEALAAVGDTGSLNFLINGFCMGICSGFAIPIAQAFGAKDETEMRRYVMHSVYLCAVISVLMGLLTGVFAPQLLRMLNTPEDILPLSVAYIQPVFFAIPVTVLYNMCGGVMRSLGDSKTPVIAITIAALLNIVLDYTFILAFHMGVEGAAWATVISQLISGLWCLLVIRKRFTILKMQPEDKRIRAPFVRRLLAMGIPFGLQYSITAIGSLTVTYAVNGIGTIAVAAVTAGGKLSMFFCCVFDALASTMATFAGQNVGAKRLDRINQGLKASSIIGCVYCVLAFVAIYFFGKPMVGLFISQDSADRQLVIDMAQQFLIINSALYIPLLFVNIVRFSIQGLGYTMIAMIAGLMELVGRAVVAMLLVPSLGYDAACFANPVAWILADLFLFPCYFTCIRKLQKRLYPEKAAASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAA8</accession>
    <name>R7IAA8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47452">
        <property type="protein sequence ID" value="CDE47452"/>
        <property type="gene ID" value="BN770_01254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="237" mass="27514" checksum="B15C5A51CB06AF3A" modified="2013-07-24" version="1">MLLRIAIVDDLPQDAERLQQALTAEGQTNIIRYESGDALLSAISPEQLDALFLDICMEGTNGIDTARKLREQAPTLPIVFVTSSKEYVWQSFPVHPFDYLLKPFEQARIRQLLDDLLRILQHPEPEIEVRFARKLMRLPYSKVYYALAQNHFVRIMSDEGECRATGIFAQVEKELCADPRFLVCNRGIIINMSAVLRFENDCIQMLDGTQFPVRQKDKGRLFATFTQYQFRHMRREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAU8</accession>
    <name>R7IAU8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WefE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49024">
        <property type="protein sequence ID" value="CDE49024"/>
        <property type="gene ID" value="BN770_01900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="71" mass="7969" checksum="7A96032D82A92745" modified="2013-07-24" version="1">MIVAKNAAAADFVAREQVGVALNSLRELPELIRTMPEEDYQRYAANARRVGAQLRAGENTKRALRKLEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAZ0</accession>
    <name>R7IAZ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49074">
        <property type="protein sequence ID" value="CDE49074"/>
        <property type="gene ID" value="BN770_01912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="2">
        <location>
            <begin position="262"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="361" mass="40132" checksum="CD961A623C89C272" modified="2013-07-24" version="1">MCNVNYLIEIRRFNTFAARTRLPASAQLLWYKLIEIMNQHARGGDWCDGFLRIDNPYLLAYFPMSATALADARRTLCEAGLLEYIPGEKKRTPPAYRLHYFSVCDGKGAVERDYPREISADSTADCPADCPEIRDDPRDNPDSPADCHADCPEIRDYPRDHPNYPSVYPSDCTTVCPTDCTTDCHGNTPDFYDTNINYTETETETVNPTGKTNDDEKETSAFSAGYAGACTGAYACTDAGAREGAFPRSVRESAKLAGKVLLHQVFTENQLNRVMAAFNRYPFEDGLMIQAVAKTAEANPTNAVNYLIQLLTDWGDAGIRTVAEMEDYLYARDMAQGNALMHTREEGRELLAAFKAEHGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAZ1</accession>
    <name>R7IAZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000109">
        <property type="protein sequence ID" value="CDE48468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48468">
        <property type="protein sequence ID" value="CDE48468"/>
        <property type="gene ID" value="BN770_01706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="162" mass="18225" checksum="944BD4BDF845C3B1" modified="2013-07-24" version="1">MSKLTDKVSYLKGLAAGMKLNMEKDSNKLLLEILGAMGDMAEEMQRMDEAHRELQDYVESIDDDLSDLTETLFSDEEEDDEDADDADECDCEDCADDTDDEDDAAEEENPDDDLIAYACPNCGAELTFHANDVDFDENTLCPNCHQPIFPEIDEDSEEETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAZ2</accession>
    <name>R7IAZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48661">
        <property type="protein sequence ID" value="CDE48661"/>
        <property type="gene ID" value="BN770_01776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029478">
        <property type="entry name" value="TM1586_NiRdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14512">
        <property type="entry name" value="TM1586_NiRdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TM1586_NiRdase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="250" mass="26603" checksum="366931123731D3E6" modified="2013-07-24" version="1">MTTLETLFSPMQKEKLRQAALVRTSCRSFAGAPDTAAFAALSYVVGRCTLPGARLVLTPVDESLFTGTILGMGRITGCKMAAVVIACGTEALCRVNAGILGEAFVLEATALGLGTCWVSGTYRRKQIRLPMQENETVLAVIAVGVPEKPLQAPENRRRKPLDKLMNAVPADGMMLDAAKLVQIAPSAMNMQPWRMEALPGAFALTISDRALLDGGIALCHAELALRGVHRWVYSAAHGGITAVAQGRFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBR3</accession>
    <name>R7IBR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49329">
        <property type="protein sequence ID" value="CDE49329"/>
        <property type="gene ID" value="BN770_01976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="377" mass="38947" checksum="DD7F1CA68A6C0415" modified="2013-07-24" version="1">MTLRDALDFALTSLRGNLAKSLLTVLGLGVGVGAVLTVLSLGDAGEIRVEEEIARLGVDKVWFCAENPAYPLTEDCRAIAASTGADVCLGASTMDAVSLGGQTVYAQIAGYDDGLEAVHHPSSVQGRIFTVREYSGERVALLDETLAGRLNAAVGDFINCGGRRYCIVGVVAGMPAQSASLGSGMLLLPLQTWQDAYALAPTELALAVPKGEKAGELAEDVLAKLHNLPGKYLSVTLENEIDAAKSVVRIFVMVLACVAFVCVATGAIGVMNVLLISVRERRREIGLLKAIGATSRQVALLFLLEAAAYAALGGLLGILLGLGMTALFGALIGLMPQVKLLHMGLLLAGAAALGLSFGVIPAAKAAGLPPAQALRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBT8</accession>
    <name>R7IBT8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47977">
        <property type="protein sequence ID" value="CDE47977"/>
        <property type="gene ID" value="BN770_01467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447776" evidence="2">
        <location>
            <begin position="22"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="482" mass="54429" checksum="317A7D8EA99CACAE" modified="2013-07-24" version="1">MKKMLAILLALLMMLTGMATAEETTDNNTNISHMLELCQRVDILLHSDRIVADLVGDTDAAITEEQKIVNRLRAGNRTMPSAVYYVTGETLLAGFIGDNPDYTDTPEQRRVLQLMPQRILMEQQDTYGKQMLNQMARSTQYPKPDGEPEMGMYIALYADALPMMSFWISDGTVNEMYCTPVLSDELAACKSAEEVTAWFAAQQMPELACTAVDLAGVAAYPFAEDPFGDEGEPVPFERLAEAGNALDELIESRYLQTTWGISDEDVAKLAAYAHEGQSPRSIYRIELMESSMAQMLRLTYRSEAPQVLYEVTCSWAMEMYHMVTLFAMYDEYNAGVRTLYQQEEDEDEESDSLFTDETSETDTPDESLKTEVENFQKLMQEIDARYSLIMNQATQKHLYLDLNERTNAMYVLLYDEGAPILVMSSMENGVSCLHVRYFPTAQLENCQNTTDLMFYFTGNNVPFEVTEILPQGDLADMAEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC37</accession>
    <name>R7IC37_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49444">
        <property type="protein sequence ID" value="CDE49444"/>
        <property type="gene ID" value="BN770_02022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="194" mass="21927" checksum="61D5F645D35C7355" modified="2013-07-24" version="1">MCGRYFLADSGNSGELRGIIDQLNRRGATVKTGEIFPTDTVPVLANNRNRRVMPFSMQWGYTLPDGRLLINARSETAGEKPLFQDAMCQHRCLIPATNYFEWEKRGREKIKYAIRQADAGLLYMAGLYRVENGRAVFTILTREPAEQIRFIHDRMPVILTSDAKQDWLNLDCDAAQTLAQACENVAFCAVDVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC71</accession>
    <name>R7IC71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">BN770_00112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000079">
        <property type="protein sequence ID" value="CDE48102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48102">
        <property type="protein sequence ID" value="CDE48102"/>
        <property type="gene ID" value="BN770_00112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="140"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="140"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="378" mass="41528" checksum="637426283028F6F1" modified="2013-07-24" version="1">MANKRDYYEVLGIDKNATDEDIKRAYRKKAKECHPDLHPNDKEAEARFKELNEANEVLSDPDKRARYDQFGFDGPDMGGGAGGNPFGGMDFSGMGGMGDIFDQLFNGGMGGSAQARRNAPRQGNDVRYELRLTFEEAAKGCHKSVEFYRYENCATCGGSGAKPGTQPQTCSMCKGTGQIRQSGGWMTTVRTCPACGGSGKVIKDKCSSCGGSGRVRMRRTLELDVPAGVDDNIVLSKRGQGEPGANGGPNGDLLIQITVKPHKLFRREGTNLRLEVPISFTQAALGAEIDVPTLDGSVKYTIPEGTQTDTEFRIRGKGIQQLGSNNKGDLIFKVRVETPRRLTEKQRELLRQFDGDDNGKQYDQRKTFIDKVKELFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC93</accession>
    <name>R7IC93_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsH</name>
        <name evidence="11" type="ORF">BN770_01542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000080">
        <property type="protein sequence ID" value="CDE48122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48122">
        <property type="protein sequence ID" value="CDE48122"/>
        <property type="gene ID" value="BN770_01542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="641"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="222"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE48122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="684" mass="75238" checksum="38C96D9FD878FE51" modified="2013-07-24" version="1">MKKSRGMFGYVAVLLLMVLTISMLFTNGFGSNTRDRRITYPQLLTMIEEGQVRSVAIRGTSLVGVTTTTTVADADFPDKNYDFETTIGADFIVTARQMQAAKLNKPLDEVSVKDLPFTIIYRQPLTTPWWYDLIPLAISLVLCGVMFWLIMRAQTGGNGKVMNFGRSRARIHDPNKNKVTFADVAGAEEEKEELKEMVDFLRNPKAYIDMGARIPKGVLLIGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFDQAKRAAPSIIFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFAINEGVIVMAATNRRDILDPALLRPGRFDRTILVNYPDMAGRVAILQVHAKGKPLADDVDLENIAKRVPFSTGAELENIMNEAAILAARGRLKAINQQTLVEAISRVQMGPEKRSHKVTQRDKRMVAIHEAGHAIVGHVLPNCDEVHLITIVPRGQAGGYTLSLPTEEDDLQTYSQLMDFVAMGLGGHAAEQLYLGEFTTGATSDLKKATEVCRRMVTQFGMSEKLGPVYLDGDQEVFVGMEFGQSRGYSEEMAARIDAEVKRLLEECYQKAVDALSANRDRMEKLVDALLKYDTISRREFVTLMETGALPDIQDADTRTTGDVMMQDMADEKKEESSEKSAETPEKSAETPDKTADAPENHPDAPHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICA0</accession>
    <name>R7ICA0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000125">
        <property type="protein sequence ID" value="CDE48918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48918">
        <property type="protein sequence ID" value="CDE48918"/>
        <property type="gene ID" value="BN770_01858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447809" evidence="1">
        <location>
            <begin position="26"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="776" mass="85696" checksum="470BAB4E5A0DDB0B" modified="2013-07-24" version="1">MKHFSRVLCLLLMLALLLPGALAEAVEQTEQIDSGIEEDEVEKVGDIFDMYQVGSMVEANGKLYTISYGPTICEFDGENWRIAVVASSFSDVLRFSEDGSFYSDETSAVLSVDEDGTLLLLYPYSDGVIDLLRVPLDGSDVTRVHSFRLVEDSGDEDGSLYFSLQGAALTSDYAYVTAYGMNPEATYGLNQLFELNLKDGSVRKVTEDYIGVILPLDDTSLIGYYDNRYTGADDPLTAPVRINRQTGLTDTLCEMESDSSFSGFTMSGTSVVFNDGSQVLRVAAPYDTLETVGYLPPAYVYTNLPGCVSGNSYYTYNYDAGLTSVDLTAPLPATVLRIDSSISWGDAGELVRQYAKEHPEVGIVYASTSASTAPDYTQHMQSGEALDLYSFYLPGDAFAALRNKGYLAELSGSSDLLAAVSEMFPNLTKQVLVDGHLYALPVEVSTSCWSIDTAVLEDVGLTAEDVPTTYLELLNLIDEWITSYVDDYPEHALMDYPYSLSMQLFSQIMMAQIAECEADGRTLTFTDADFIATLNKLDSMREKLKAYEDQWNADNNSGNIVYSSSTMIGGSYDASSEGPLLSSYANIGIHYASDRESTAVPLMLSIQPNHDSSVIGNIRVMAVNRSSKNADAAMNLLTYLAVNRSDYQKSLLSPAYTDNIEDPHYEETKASHESYIDELTKAMATADDSEKRDYQEAIQNLTDALTRLSPYQYTTEDILLYDSQMENVRIIESTVFYGDDNEASTLVNRYMDGNITVDQFVRELTRIVQMMIMENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICB5</accession>
    <name>R7ICB5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000145">
        <property type="protein sequence ID" value="CDE49524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49524">
        <property type="protein sequence ID" value="CDE49524"/>
        <property type="gene ID" value="BN770_02040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="158"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="383" mass="43465" checksum="E4A09CFD6B996E94" modified="2013-07-24" version="1">MPNQQPTYREQVDAQRIIQIREILKGLPQACGDFIRSIAVTTGTFTRLAYAIDLRTFFTFLQRERVAFADTPLTHLTDQQIGSVTQSDLTAYIEYLTYYFKEQDADEETAPLKPLVNHELAIKRKLSAIRSFYEFLFKNQRISANVTTLVSLPKIHEKPIIRLSQEEMVRMLEQSATGAGLSERQKTYQKLTAKRDFALISLFLGTGIRVSECVGLNISDVDLENNAFLVTRKGGNQVVLYFPPEVATALADYLDARREIAALPGHEDALFLSLQKRRITQRAVQNLVKKYASVAAPLKPKISPHKLRSTFATNLYQETGDIYLVADVLGHSSVDTTRRHYAEMTDRRRRMAAERVVLPTLEEVTGHQPPEQDENQDTEKGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICE3</accession>
    <name>R7ICE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginine/lysine/ornithine decarboxylases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000084">
        <property type="protein sequence ID" value="CDE48172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48172">
        <property type="protein sequence ID" value="CDE48172"/>
        <property type="gene ID" value="BN770_01570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1_C" evidence="2">
        <location>
            <begin position="122"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="204" mass="22511" checksum="838540F554040D4E" modified="2013-07-24" version="1">MLSIDDSRAWMEENGRARLRALSETVNDVRRRLVGTPYHDAYADWANLPVCFDPTRLVISAPQGGKCLAEQLREAGLDVEMADERRVVLILSVMDDTAEIRRLPELLASIPAAEKKQFAPLTLMLDMPEAVLTPRQAAMAEEILVPLDRAEGKIAAAAVGLYPPGIPLLAPGERVTREIIRQLQEAGTRERFGVEGDDLRCANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICJ1</accession>
    <name>R7ICJ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA interferase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PemK/MazF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000130">
        <property type="protein sequence ID" value="CDE49018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49018">
        <property type="protein sequence ID" value="CDE49018"/>
        <property type="gene ID" value="BN770_01894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="111" mass="12581" checksum="4A8570F7F4339857" modified="2013-07-24" version="1">MSTYQPKQGDIVVMNFNPQAGHEQGGRRPALVISNASFHRYTHMAIVCPITSKTKDYPMHVPLDERTRTQGEILCEHVKSLDYQARGAVCVETLPEDLLQDVLERVRMSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICT6</accession>
    <name>R7ICT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000096">
        <property type="protein sequence ID" value="CDE48327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48327">
        <property type="protein sequence ID" value="CDE48327"/>
        <property type="gene ID" value="BN770_01652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="193" mass="21107" checksum="A5045CF9C2CE8093" modified="2013-07-24" version="1">MFVEMVHHPTTKGEILMKKRVLSALMALLLLIPAAGSAEEAPMLLESYASRGARQVTFAYPEGCTVEVEDKIGTMVFMDDETYVVVVVTHKGSSGIDEIREAIGDSSLIFALTDDMHLYATHGMLNYPLLTNYDYVEVGLNLPGGVDVVVASQCLYGDTAVYDLLLTIVGSLTDAAPLQTWLEETWIPTVMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID06</accession>
    <name>R7ID06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage 0 sporulation protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000140">
        <property type="protein sequence ID" value="CDE49291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49291">
        <property type="protein sequence ID" value="CDE49291"/>
        <property type="gene ID" value="BN770_01960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="290" mass="32367" checksum="6FDB59C00DBDABC6" modified="2013-07-24" version="1">MPKKTHGLARGLDSLLPEVDMMTSGGGQEIAIGDIDPNPDQPRRAFSEESIAQLAQSIREQGLLQPILVVPMNGGRYRIVAGERRWRAARMAGLDRVPCIIREMDVPTQMEIALVENLQREDLNPIEAAQGIQTLMRQCGYTQEAVAARLCKSRPAVANLLRLLTLPEDIITMVRQGTLSAGHARVLAGLESDEMKMTLARQTITNEWSVRQLENAVALMRKSTPTLPKTPQKVHSLPAELTELETFCRETFGVRATITGNQKKGKITLQYYSAEELEQVYELLHQLHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID07</accession>
    <name>R7ID07_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_01933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49193">
        <property type="protein sequence ID" value="CDE49193"/>
        <property type="gene ID" value="BN770_01933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE49193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="339" mass="38330" checksum="E9C2F8398A849BD8" modified="2013-07-24" version="1">MKCIELFAGAGGLALGIEKAGFETIGLIEINQQAAETLKKNRPNWNVICDDIANISCLNLEERFQIKKGELDLLSGGAPCQAFSYAGKRLGLEDTRGTLFYHYAIFLQKLQPKMFLFENVRGLLTHDGGKTYQTMLTVFEEAGYSIQYKILNAWDYGVAQKRERLITIGIRNDLIEKIHFDYPIPHEYKPVLKDVLTDVPQSVGTRYSIKKEKIFSLVPPGGYWKDIPEDIAKDYMKSCWYMGGGRTGILRRLSMDEPSLTVLTSPSQKQTDRCHPLEPRPFTVRENARCQSFPDEWEFCGTVGEQYKQVGNAVPVNLAYEIAREIKKAIEGENAVCGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDD1</accession>
    <name>R7IDD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000115">
        <property type="protein sequence ID" value="CDE48587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48587">
        <property type="protein sequence ID" value="CDE48587"/>
        <property type="gene ID" value="BN770_01730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="218" mass="23365" checksum="6D14770810131174" modified="2013-07-24" version="1">MKSLRMNKEQKQFLLTSLFSGIMIGIGCTVYLSCVNKLVGALLFCAGLFFILTNGGTLFTGICGLKTPVKKLAWVFVLNGLGTVIPAIVSWSNVVDGATKLGATAAAVMLGKLGMNPVSWLLNGLMCGVLMYLAVIGYKKAKDSLHGIAAVLFAIVGFIVCGFEHSIADMGYLAIAIPNLSFWQILQCMGMILVIMLGNVFGGKLMRMVLVDWQEKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDF9</accession>
    <name>R7IDF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49333">
        <property type="protein sequence ID" value="CDE49333"/>
        <property type="gene ID" value="BN770_01980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="95" mass="11055" checksum="F8DD733828D4E7E4" modified="2013-07-24" version="1">MSEIQDEDIITLTDENGNDVEFLLLDVVEYNNDDYMVMIPLDDEEIEDDDEQDEVVILKVIREGDEETYSGVEDEDVLNAVFEIFQEQNAEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDQ3</accession>
    <name>R7IDQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49448">
        <property type="protein sequence ID" value="CDE49448"/>
        <property type="gene ID" value="BN770_02024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="330" mass="36032" checksum="F847B42C99381497" modified="2013-07-24" version="1">MFDIISFIPRAVVQGVPLLYGSTGEILTEKSGNLNLGIPGIMYVGGICGVIGSFFYENSLPSKADISALPAILIPIVCCLLGSLLMGLLYCLLTVTLRANQNVTGLAMTTFGVGVGNFFGGSLIKLSGSEVPSIALSGTSYFFHRPLFAESEGWFYQDFLSYGFMVYLAIAIGFFVAWFMKHTRTGLHLRAVGENPNTADAASINVTKYKYMATCIGSMIAGLGGLYYVMDYASGVWSNNAFGDRGWLAIALVIFTIWRSNVGVFASILFGGLYILHMYIPTGSNPAVKELYKMLPYIVTIVVLCISSLRKKREDQPPQHLGLPYFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDR0</accession>
    <name>R7IDR0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49581">
        <property type="protein sequence ID" value="CDE49581"/>
        <property type="gene ID" value="BN770_02048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040877">
        <property type="entry name" value="CBM65_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18259">
        <property type="entry name" value="CBM65_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447867" evidence="1">
        <location>
            <begin position="22"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="CBM65_1" evidence="3">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CBM65_1" evidence="3">
        <location>
            <begin position="165"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="304"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="481" mass="52027" checksum="F89FD3222CD0ECB0" modified="2013-07-24" version="1">MKKKCLLVCLLCCLLLGLALAEEPMTETVLFEGSQPASGGWNLALTIDTTNVNGTFDPSLISENGYFAVTYDGVQNGVYLALSDWEGGVWAQINVPSTCTQTDGMYTAVFSFEQCRMAYGSIDFAAADQICVGTSASTKTMVIHKVAWYGAAQTDSLGADEVLFSGAATSAAQNECLVFRFTQHVGGTFDASQMRTDSRFYVEYSGAKYGVYLALSSHSGATQWAKVNASETVEVSEGRYGAYFDESAMAMAFGSNFARLDQISVYSSGKQPVTLHKLAYFAGTGDVVDTSDGRWDRPDTGIAFIGDSICQNAKLLYGDWNTILGRSDCANYGIGGQTTLECRARIGELAACNYRQIVFICGINDIGHGYTKEEIVQNYAAMIETVQANNPDCQFVILSTLPTTSAFYSGQQGKITLLNLAFKRFANKTPNVTFVDAYSAFCPKAGEYAYPELLSDGLHPNAEGYAKIAEMLTPYLLPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE10</accession>
    <name>R7IE10_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50064">
        <property type="protein sequence ID" value="CDE50064"/>
        <property type="gene ID" value="BN770_02265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="80" mass="9050" checksum="09272013B053928F" modified="2013-07-24" version="1">MTEVRLGEKAQELLLFYAGMNEGAEITASALQSETSLTLTGSQTYKNALLLKRLILRNRRLNLIVVNWKRIKLLAELSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEG4</accession>
    <name>R7IEG4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50020">
        <property type="protein sequence ID" value="CDE50020"/>
        <property type="gene ID" value="BN770_02234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436472" description="Beta-xylanase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="6">
        <location>
            <begin position="27"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="400" mass="44996" checksum="F9EB0CEFA227A6B1" modified="2013-07-24" version="1">MKRMLSILLMLMLVPCAALAEEEAEPVTPMHELTMAHGFRFGGALSYMQLWDANYLNFLKTHCNSITATNEMKAYSLLDQSKSRASSDGMPRMNFSAADKMVAWAQENGLGVRGHVLVWDAYMTPWFFHEQYDAGKPLVSREVMLQRLESYITQVITHFEEKFPSVVYCWDVVNEAVGEGSEFDPTDPRHIRTTRSGVSNVFYDTIGSDYVEYAFLYARNTVDALGADIRLFYNDYNTFYAEKRDAIIALTRSINSFAVDADGNPRKLCDGVGMQGYIGGYGTQAGCMNVNDLALISTAIKTYAAEGLEVQLTEMAVRNFDAAKVEEHADFYVRLFKVLCAVNRGGTQPLTGVSVWGMFDFPNDQPTSYTYKMNGTHSGLLNEKGIPKDVFWQIEEMLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEP6</accession>
    <name>R7IEP6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49788">
        <property type="protein sequence ID" value="CDE49788"/>
        <property type="gene ID" value="BN770_02138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="235" mass="27235" checksum="5771E729B39E696D" modified="2013-07-24" version="1">MDQLAMLWQYQVEDRKADKLEQELSRSPLRQKMNTCRTQFNAKQKQYKQMEEQVAILSDRKDAIRDAITRCEEQLRHLQSRFEQNPPTELDDTKALLSEVNRFLETIGSYEQEMKRMAKDANDYDQKERSLRRDAIKLKEEFDNLKKQYDKESPEKEAALKAQKAIVAKKGEGISPELLARYHEIKKRITPPLARLINNQCSGCNMSLPSAVLSRVTSANGEIVECESCGRLLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEU4</accession>
    <name>R7IEU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase B (NAD(+)) electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000135">
        <property type="protein sequence ID" value="CDE49102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49102">
        <property type="protein sequence ID" value="CDE49102"/>
        <property type="gene ID" value="BN770_00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="240" mass="25784" checksum="080CB8138A994000" modified="2013-07-24" version="1">MRFAIKQNTPLTSCVYRMVLQGDTSAITAPGQFVQVQVPGFYLRRPISVCDWDSETLTLVYKVVGNGTDAMCRMIPGTELDLLTGLGNGFDITRCGERPLLIGGGVGLPPMVGLCRCLMQAGKHPTVLAGFNTADEVFLREDVEKLGAPFVLATMDGSAGIKGLVTDALPEIDFTDICACGPLPMLKAIMNADDHPAQLSFEERMGCGFGACMGCTVKVKGGYKRICKDGPVLVREEVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEY5</accession>
    <name>R7IEY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 2 candidate beta-glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50359">
        <property type="protein sequence ID" value="CDE50359"/>
        <property type="gene ID" value="BN770_00174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="885" mass="98954" checksum="E6089A6885D94678" modified="2013-07-24" version="1">MMKIDLSGQWRVKLDAEKQETMPQAYPETMTLPGTTSAAGLGMPNSAKETGCLTDAYRFEGAVWFMRTFTAGDWTGEQTMLTLERTRKTTVYLDGRPIGHQESLCTPHRYFLPPVHAGEHTLVIRVDNTDYPTRGGHLTSPDTQSNWNGITGEISLTVAHTLLTDLTVRPDLRRGCLRVHGHIIGAPDGGAGIVLPGQMEHLLPYRRGVLDGECPLKGNEAFWDEAHPEIHTISIDLDGDVYETTFGLRDVRTLGRRLLINGRETFLRGKVDNLLYPKTGYTPTDVASWMTILGIAKEYGINHYRYHTACPPDAAFTAADLLGVYMAPELPFWGTVAEEGEEGYDERQRDFLFQEGFRILREYGHHPSFLWLSLGNELWGSKDVLNRMMRAYREADDTKLYSSGANNYQFVPDVLDEENVFVGVRLGRERLIRGSYAMCDAPQGIVQTTAPESVSNYDASIVPETLGQSGEAGKVQIQYGTGVKEVDAQSADALIPDVPVISHEVGQYVFYPDFSEISHYTGPLKPCNIEAMREKLERAGLYGEHEAFFRQTGHLAVDCYKREIETLLRSREVSGFQLLDLQDYTGQGTALVGVLNALMENKGLISAEEWREFCAGTVVLGEFASFTGMMGEDIRFDVQISECDPEKQHTCIRCTLMDGERELYACDVAPGARQGRLTDAVSVTFPAECYRDAMQERITGLTVALTLEDGTRNHYPIWLIPRVDIRITREGIEKDGRMVAFVSAEEKADGAAIVVPSAEGQLPAEYCTDFWCYPMFRSISESMGKPVPVGTMGLSIDTASPLLKRFAQEDYTIPAWYAILQTAHVQRLPADIRPAVQMIDNTERCARLGILYQQDGVWHLTARLWEKPNDPTVRALAWSLWEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF26</accession>
    <name>R7IF26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cna protein B-type domain./Gram positive anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_02320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000164">
        <property type="protein sequence ID" value="CDE50210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50210">
        <property type="protein sequence ID" value="CDE50210"/>
        <property type="gene ID" value="BN770_02320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026466">
        <property type="entry name" value="Fim_isopep_form_D2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032334">
        <property type="entry name" value="GramPos_pilinBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16569">
        <property type="entry name" value="GramPos_pilinBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04226">
        <property type="entry name" value="RrgB_K2N_iso_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448224" evidence="7">
        <location>
            <begin position="24"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="GramPos_pilinBB" evidence="9">
        <location>
            <begin position="218"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="10">
        <location>
            <begin position="386"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="8">
        <location>
            <begin position="502"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="546" mass="58800" checksum="150AE5956B4455C4" modified="2013-07-24" version="1">MKKFWAILLAMMLVLSMVTVAGATEVENPSTGAEGFTITVNPKDDVDHEYQVYQIFTADVETNAGEKVLTSVKWGTNAKNDTDAVRTGDPVPDAVLDALKAVSGTNQEKLAEITKYWNADSTPVDTFASTKAAPGTSKKLTPGYYLVRDNQAKLEGKDGAATLLIVKVLDQDIVATAKSEKPSVDKQVQDEVADAEKNGGEVNPEGWGESADHALFENFKFRLVATIPVNADYNDYPTYKLVFNDTMSKGITFVQIDSVKVNGIALKATDYVCTATPGQKGAGKVGENQDKPSWTLTIEDLKKVMKENTSILVTDKITVEVVYTAYLNEEAQVFNASANSTDNKNSVDLEYSNNPNADGMGKTPEDHVWLFTYVVNNTKYANTAEAGNELEGAGFTLYDQNDRVVPLWKDAAGNYVVAGTTKPNDTYTDVANNEMITEANGTFNIIGLDHGTYTLKETTVPATYNPLDPVTITISADHKEAAGGASATMELTAASTMNNKLVNKSGATLPETGGIGTTIFYVLGGMMFVGAALILIVRRKAEADEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF36</accession>
    <name>R7IF36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49943">
        <property type="protein sequence ID" value="CDE49943"/>
        <property type="gene ID" value="BN770_02204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="93" mass="11209" checksum="D98A2CAF37E43440" modified="2013-07-24" version="1">MQPKLPQDERYEQRPDGTIRRFRQQTPPAQSTYIPQPPPDEPPRRRKREKHRHRRVWLYVFALIGVAFVAVEIFRYLIVPLLVQLHIWTGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF58</accession>
    <name>R7IF58_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50091">
        <property type="protein sequence ID" value="CDE50091"/>
        <property type="gene ID" value="BN770_02268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="175" mass="20457" checksum="1697087B9E6D191E" modified="2013-07-24" version="1">MTESEYIQQHETYLSSIVSRFIARYPEQRGKMRDDLMQEARIALLIAYRKQENTAGLERRAYICIIDALYTAAVHAYPIRIPRRKFRKNVGRFSCCGSDALALWEKNQPEDESAQEMELWAILAGMNDKEQAFVRCRLDGRNCIEAAKMLGMSKSACCRMQQRIRRYLMTQMRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFC9</accession>
    <name>R7IFC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50166">
        <property type="protein sequence ID" value="CDE50166"/>
        <property type="gene ID" value="BN770_02308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="13"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="203" mass="22221" checksum="5BDF1F56C2FB006A" modified="2013-07-24" version="1">MADFRTFDPCNLLAPVPAVMVSCRAPEADAKPNIVTVAWVGTVNSEPPMMSISVRGNRFSHDLIAKSGEFVVNLVDETHCKALDFCGVRSGRDVDKWQECHLTPMKALNMDYAPAIAECPAYLACKVVQQLELGSHTMFVGKIVGVQVRDDLFAADGSLHLEKAGLVTYTHGTYQKAADVLGFFGYSVARPEVLKRRMDALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFI7</accession>
    <name>R7IFI7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000164">
        <property type="protein sequence ID" value="CDE50211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50211">
        <property type="protein sequence ID" value="CDE50211"/>
        <property type="gene ID" value="BN770_02321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05827">
        <property type="entry name" value="Sortase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042002">
        <property type="entry name" value="Sortase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="283" mass="31214" checksum="B2EA4636D0D7840A" modified="2013-07-24" version="1">MKRNMTTILLFVVLFVGLALLLYPSVSDFYNSFHQSRAVATYNTVVEQESKKDYEADWAAANAYNEKLRAQSTVDRLIMTDEEREEYDAVMNVGGSGIIGVIEIPQIAVTLPLYHSTNANVLQVAVGHIEGTSLPTGEPGTHSAFSAHRGLPSAKLFTNLDQLTYGDTFTLRVLDKVLTYEIDQILIVEPHDVSALQIYDGMDLCTLVTCTPYGINSHRLLVRGHRVETSLAQLSVRISADALVIDPYIVAPIVAAPMLLILLILMLVTTSPKHKKRKGAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFP7</accession>
    <name>R7IFP7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VanW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50445">
        <property type="protein sequence ID" value="CDE50445"/>
        <property type="gene ID" value="BN770_02395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435842" evidence="1">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="370" mass="41191" checksum="267B61D06EAF2CE5" modified="2013-07-24" version="1">MKRLMALLLMLCIALTGVALAEDELYEEVDDSEFNEDEVIHVVGAVYPDKVLSDFDSNSPALYTARMTAYTSGYVDRDIKSTRVFRVGDTSARGEVLYVDPTWVIMRYQGDLAYVKRHRIFSVTPVDSSTTPPYGTQKHAYVAKTAATCYVRKSMSDQDESWVVLNPGTTISIWCMYDGWAVVNYMRSYGYINLEQLTDLTPVSPTDNPLREDTPIAAYTSYYTMVDTEKNHNRIHNIARGGELISGVYQPGDVFDGNKIMGPYNKGKGYLIAGALSDGTASKAYGGGTCQVSSTLYNALLQLPGINILYRRAHGENAAPYLPHGVDAAVGNKTQNLRWRNDYDFPIRVEAHTSGDGALCMLIYRVYDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFT0</accession>
    <name>R7IFT0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="7" type="ORF">BN770_02348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50286">
        <property type="protein sequence ID" value="CDE50286"/>
        <property type="gene ID" value="BN770_02348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="352" mass="40012" checksum="DF57AF6CCFCF8FCE" modified="2013-07-24" version="1">MFEKYPLIVSRYEELSEAIVQPDIIADTARYQAYLKERAALEEQVTAWQSYQSLLRHREQAQEMLSDPDLHEMAAEELQSLAAQIAEAEQQLRILLLPRDPDDDHAVIMEIRGGAGGEESCLFAAELMRMYIRYAERHHFRVEPISTTETELGGIKEAVFSIAGSGVFARMKYESGVHRVQRVPITESNGKIQSSTCTVAVLPEAEDVELQIDPKDLRIDVYRSTGHGGQCVNTTDSAVRITHLPTGLVVTCQDQKSQLKNRDTAMQVLRSRLLAKMRAEKDAAYAENRRVQVGTGDRSERIRTYNFREGRVTDHRIGLTLYRIQDIIDGDLDEIIDALHAEEIVERLREMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG39</accession>
    <name>R7IG39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000170">
        <property type="protein sequence ID" value="CDE50431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50431">
        <property type="protein sequence ID" value="CDE50431"/>
        <property type="gene ID" value="BN770_02386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="192" mass="21759" checksum="AB52AB2B7B6DAD15" modified="2013-07-24" version="1">MCENKTAISKYRHIISAITADYFAHGRRIIRSVQPDYTLLLRFDNGECRRLDMNPVIQAVCSSTWPHGRTSAMSILMSGTAFRGILTRMWTVKPCGTKKSTLARMDVSWTVHQLHNKEPDSFHSVRLSPYQWLLWNSRCSYRSVSIVRTIISNSSSPMTVLRPCAYSSATKSRSVVTSGSVFGMTSSPFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGF5</accession>
    <name>R7IGF5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49662">
        <property type="protein sequence ID" value="CDE49662"/>
        <property type="gene ID" value="BN770_02082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="411"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="491" mass="55397" checksum="6434D4C170023971" modified="2013-07-24" version="1">MMRCVLPWLDSWAAKKPDAAAFEDEKTCLTWRQLHDTAKRIGTYLARQLPPRVPVALCMDKSPMTVAAMLGVLEAGCFYTIIDVQMPQQRVQLILDALHPALLLTDAAKAPIWADAAGKLPCVSTEAAASCDIDESLLAARQREIIDTDLQYVLFTSGSTGHPKGVAIRHRSVLDFVEWAVPALRLDETVRFGNQAPLYFDNSVLDIFCTLKSGAYVYFLPQRDFLFPARMMDELEQRQINTLFWVPSALMQPANLGVVKDGRPRGIKRVFFCGEVMPNRQLNIWRRSLPDADFVNMYGPTEITDVCSWYRVDRAFEDGEPLPIGFPCENTRITLVEDEICVSGTCLSAGYYNAPEKTAAAFVQHPDARGIPERMYKTGDLGAYNERGELMFLGRKDSQIKKQGYRIELGEIECAIKACQAVTQGCCFYQAATQQIVCCYSGEDDEKALRGELRRRLPKYMLPDVYYHLPQFPQTMNGKIDRVRLRQELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGM5</accession>
    <name>R7IGM5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="3" type="ORF">BN770_02416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50488">
        <property type="protein sequence ID" value="CDE50488"/>
        <property type="gene ID" value="BN770_02416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="131" mass="15062" checksum="AD578D8DCDFF650F" modified="2013-07-24" version="1">MSYQRIERISEEVRREVDRIIRDEVSDPRVTGTFSITRAEVTRDLRYAKIYVSVLEDDKREPLMKALRSAAGFVRHELGKQMVIRYAPEIQFVSDQNIAYGVHIAQVLAQAQKNQSENQPEAAANEEEPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH17</accession>
    <name>R7IH17_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">BN770_02178</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="CBJB010000154">
        <property type="protein sequence ID" value="CDE49872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49872">
        <property type="protein sequence ID" value="CDE49872"/>
        <property type="gene ID" value="BN770_02178"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="52"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="177"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDE49872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="346" mass="36813" checksum="3EC26011CA30DE5C" modified="2013-07-24" version="1">MMKSESESYKAAGVDITAGYASVELMKKHVARTMTAGCVEGIGGFGGLFALDAAGMEEPVLVSGTDGVGTKLKIAMLLDKHDTIGIDCVAMCVNDVICCGAKPLFFLDYIACGKNVPEKIASIVAGVAEGCVQAESALIGGETAEHPGMMPEDDYDLAGFSVGIVDKKRIINRETVRPGDVMLALPSTGVHSNGFSLVRKVFAIGNGGENRNYPELDKSLWETLLTPTKIYVKPVLALLKELQPKAISHITGGGFYENIPRSLPEGCCAKIKKSDVRVLPIFDLIAREGSVPERDMFNTFNMGVGMTITVAREDADKALAILHQNGEPGAYVLGEIVAGEKGVELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH66</accession>
    <name>R7IH66_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49927">
        <property type="protein sequence ID" value="CDE49927"/>
        <property type="gene ID" value="BN770_02190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="14"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="381" mass="43613" checksum="103C3DF141A3DB1D" modified="2013-07-24" version="1">MMKVYTQTWYRGNNYGSVLQAYALQHTISDMGYACSALNYKPTKADMWKLKFINHSLKETIQYKINEYLMKKNGASEAVNNLSLFDDFRAQHMQITPPCSTAPEIARICGDDAVFVCGSDQIWNPYLYDPYYFLEFVQDSRRKIAYAPSFGVMEIPHRCQQRLRKAIAPFRYVSVREKRGAEIVRELTGKQVMVAVDPTLLVSMAHWQTLARPIDSEQKYLFCYFLSENARYLETAEKIAREKHLTIRMLPMVAADFKKPGTVKEPVGPREWLGLVENADYVLTDSFHCTLFSIRFHKQFNALQRFKEGDKRGQNSRIHTLLQTANMQNRLVVPGEDATTEIISDGCFQTADARMAAQAADSRQWLEQALQSCEGAGNSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHQ4</accession>
    <name>R7IHQ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000196">
        <property type="protein sequence ID" value="CDE51155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51155">
        <property type="protein sequence ID" value="CDE51155"/>
        <property type="gene ID" value="BN770_00301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="186"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="302" mass="33755" checksum="0D2A7F209823F17A" modified="2013-07-24" version="1">MESYLFADVEAAADTMVVEGYHKPGSLTRSSGAWIHAAGTAMFEAGRRPIKPHDQWIWFAVEAGEATLVWQGHELTLKQQETCFLPAGNRDAALQIDESVRCVWIALEGPLAPMVVRKMGALLHMPLKQGALPSQMYLAKQIVQVIVRHTDTSDATYQLQHLMYGMLASHWGQPVAMDAMLSHEIAKVVDTLRANQYKDNFSLAEMAAISRMPMETFRKRFVSEVGMPPLSYVLHCKMERAKELLREEGHTVRQAGIEVGMQDPYHFSKQFKNIVGISPSAFMKQAAKPDATIRGSSKVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHT6</accession>
    <name>R7IHT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51031">
        <property type="protein sequence ID" value="CDE51031"/>
        <property type="gene ID" value="BN770_00269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="47" mass="4974" checksum="2886D4444C2A41CD" modified="2013-07-24" version="1">MNKMLIGSAVGLAMGIGLMMLPGIRQDVQKGANKVKKAVQDMSEGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7II27</accession>
    <name>R7II27_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000193">
        <property type="protein sequence ID" value="CDE51131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51131">
        <property type="protein sequence ID" value="CDE51131"/>
        <property type="gene ID" value="BN770_00292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="339"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="458" mass="51160" checksum="F0E40EAF5EEE52EB" modified="2013-07-24" version="1">MNMLHDSWWISTIDHRVSTALVFFLLLMTMGNGHKKPYFPLRILVSFIALCAVSWLTRYWIDLCLTTTVAQGIGYSLHLLVMSLLYWGTYTICYHTTLSESCYMGLLALTIFKLAWNTFKVFAAAFGMTGIASVWSRYSVSGALVSYLVYIAVCAAASLLYKRLIHSNPPLNEASRIVRASVAVFLLFQIVLEYCGHVFTSAPDSSFMFYLCALLYTATNYIILITIADLARYRQDNEEMQKFIANKMQYYQMSRDGITSLQIKCHDLKHQIATIRSKAGKESFDKYIDRLEDSIIEYGTVVECGNETINIVLTEKNILCSTCGVKFSYLIDGSIFGFMSEMELFSLFGNALDNALEGCNKVTDHEKRVISLKANAMNGMVVLHVENSYEAPLNMVDDMPVTTKAGTGHGFGLRSIQAIAEKYDGIATVVAENGIFKLTVVLHPPEGSGASRVSTQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7II39</accession>
    <name>R7II39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000207">
        <property type="protein sequence ID" value="CDE51260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51260">
        <property type="protein sequence ID" value="CDE51260"/>
        <property type="gene ID" value="BN770_00347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="213" mass="23851" checksum="D97204C7CAE0D6B3" modified="2013-07-24" version="1">MKHVLCFGDSNTWGFIPGTCKRYDEHTRWTGILQDELGADWRIHENGQNGRTTVFPEPGKNFMTGLGALPYALDTLRPLDAIIIMLGTNDLKEHSAQASVNGIGTLIRTIQTFDQLYPASVPLFGDNKPRILVLTPIEIGENVAEWDTLYGKGQESRKFPALMKGLCEWLGVEMMNTQEIVQPSKVDGIHMMPEEHRKLALAVKEKLLAMMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7II66</accession>
    <name>R7II66_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51018">
        <property type="protein sequence ID" value="CDE51018"/>
        <property type="gene ID" value="BN770_00264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="316"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="424" mass="48424" checksum="D0A8F615AE58A6AA" modified="2013-07-24" version="1">MLTNLANYLNNDFPFHMFFAVQILLAEGLFVVRMKSRLRPLKIVLPVVLCYLVLAWFHPLLGHRFARVAAIFAESLLVLCLTMDIPTTNALCIGISSYAIQNLAFKVGGLATCWMAKPRDPLFYLLSGASFVVVYAVCYLMFVRRFPENGDLKLGNWKVLFLTLVTLLTVFVRSVSLPTDISLLDRLFSILSVIMVMVLIYQCMYADEMRREKKIIESLLAREESRHQLLGKTIDSINMKCHDLRYHIDTYRRAQQLDEHAAFFDEVEQEIQRYEYTFHTGNAALDSVLSEKSLYCSANHILLTTMLDVSLLAPIEKSDIYSIFGNALDNAIQAVMAEAPENRSVNIRVSDVVGMTQIVFENFCSKPPEMHEGLPKTEKDTQYHGFGLRSIRYIIEKYDGHMSIDTKDQMFILSLLLPRPQQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7III6</accession>
    <name>R7III6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000205">
        <property type="protein sequence ID" value="CDE51251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51251">
        <property type="protein sequence ID" value="CDE51251"/>
        <property type="gene ID" value="BN770_00346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="199" mass="22872" checksum="43E9847673DDB770" modified="2013-07-24" version="1">MQRIAELVQQVVNMPGTSIENNGQVILAGTIPGTKPVQYRYEFFKPLTDEEIKSVSDSSRRPFPKQLAQLYKITNGANLFGRFIRINGIPAWGADYKQPCSLIFEDGHRTVLCPKSRLFFASYYTQPQIQVFFDTKEPEDAMRVYAARYGSNKIIAEWPSLEEWLYSEHQKYLDKLQNGDYQLVDVVEGVLTDITFNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIN5</accession>
    <name>R7IIN5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000211">
        <property type="protein sequence ID" value="CDE51316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51316">
        <property type="protein sequence ID" value="CDE51316"/>
        <property type="gene ID" value="BN770_00378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="142" mass="16644" checksum="11727B15A2172329" modified="2013-07-24" version="1">MNDFLNHLVALNTVFIQAEKDVSIFVFRHLRELGYAHLLYKPKKADYALYWEKDCIVVTDMISEAPLSASAPHEICLEKMLVDMYCDKLISSAYSKSEYPEVLKQAMETYHIEPSKMMRYARRRGREDEMKEILEEIENAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIW8</accession>
    <name>R7IIW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000219">
        <property type="protein sequence ID" value="CDE51416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51416">
        <property type="protein sequence ID" value="CDE51416"/>
        <property type="gene ID" value="BN770_00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="236" mass="26207" checksum="9BDB05534F2E2606" modified="2013-07-24" version="1">MRAIWKRELQAYFLTPTGYVFMGVFLLLSSVMFYLQIMQARSSDLPTFVGQMSYLWMLLSPVLTMRLLAEERQRRTDQLLLTSPVSLSGMVLGKYAAAYTVMAATVVLTLGFVAVVAVYGRVYPAEMAVAYLGFILQGGAFLALDLFISGCAKNQVTAAVFAFGANFVLWMLDLLENAVNSSFFSSVLSFFSLYQRAEPFLMGQLSAASVVYDITFAAAFLLLTIHTLDARRYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIW9</accession>
    <name>R7IIW9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000239">
        <property type="protein sequence ID" value="CDE51714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51714">
        <property type="protein sequence ID" value="CDE51714"/>
        <property type="gene ID" value="BN770_00580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435941" evidence="1">
        <location>
            <begin position="22"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="275" mass="29455" checksum="F480574AB125103A" modified="2013-07-24" version="1">MKKGVFLALLLMLLAAFPALAEDVYYADASQGGSVTSDKGYLSVSCPLDTDSRVTMTIRDEWGSTVYQRDYGVCSGMFASEEVYLPQIGAQTTYRVTLSTDSGENSFTVIRVAPRLTDSNVTTAGLPLSDISGVSSPKKAILLDLSALNNQLPMVVPMVSGDVQLGCVTFTVRNGQLSVSAELTVDGTIDRAAVYVAKSALSAQTLGTRRFDGKKVGLNKKVNVDGLGYAAVLVQMTVSYDQDTATPLMPDEDFVQEQTELWDAMQEETVNEAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ12</accession>
    <name>R7IJ12_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CBJB010000241">
        <property type="protein sequence ID" value="CDE51734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51734">
        <property type="protein sequence ID" value="CDE51734"/>
        <property type="gene ID" value="BN770_00591"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37529" checksum="9FE67DA400236ABA" modified="2013-07-24" version="1">MKILLTGGAGFIATHTCVELMAAGHDVVVVDNYVNSQPEALRRVEEIAGRPVKAYEADVCDRAAMDKIFSENRFDAVIHFAGLKAVGESVHKPLEYYRNNLDSTLTLCETMRRHGCKRIVFSSSATVYGVPDEVPLREDMFCKGCTNPYGWTKYMIEKILQGIVTADPEWSVVLLRYFNPIGAHESGRMGENPNGIPNNLMPYITKVAAGQLDHLTVFGNDYNTPDGTGVRDYIHVVDLAKGHVAACDYAAKHNGCEIINLGTGVGYSVLDIVNTFSRVNQVPVPYVIGPRRDGDVDACYADPTKAKELLGWTATKTLEDMCRDSWRWQKANPNGYQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJF4</accession>
    <name>R7IJF4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bac_transf domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000241">
        <property type="protein sequence ID" value="CDE51730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51730">
        <property type="protein sequence ID" value="CDE51730"/>
        <property type="gene ID" value="BN770_00589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="136"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="339" mass="38376" checksum="412C23C99D5B1D4F" modified="2013-07-24" version="1">MQMALVLLAMSFGARVLPKLQKPARLLLITEADADEIRQKLAKERTFGQLNDVCSWQAAELPAFLAQNDAVLIASDVPDENRMALMKACYALKRTVLVSPRVQEIMLSSANQVILDDAPLLEMRADGMTLGQKIIKRGADIVLSALALLVLSPLMLLIALAIRVEDGGNVIFRQKRLTADGKTFTICKFRTMRRGSGGASARDADNRVTHVGRFLRRWRLDELPQFWNILRGDMSLVGPRPEMLENITRYKRDLPEFQFRERMKAGLTGYAQIEGRYNTSPEDKLALDLFYIEGFSLWTDMKLLLRTVTVFFRPDATQGFPPEDSSFIPKHDKTQEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJI5</accession>
    <name>R7IJI5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scpA</name>
        <name evidence="3" type="ORF">BN770_00711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ScpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51944">
        <property type="protein sequence ID" value="CDE51944"/>
        <property type="gene ID" value="BN770_00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="259" mass="29597" checksum="ABD4081FE3AB6FE0" modified="2013-07-24" version="1">MAMTFQLKDFDGPLDLLLFLINKEKIDIKDIFVSQITDQYIDSVRNAPDLDMDDATDFLVMAATLLEIKSRAMLPRPPRIEEGEEDPEEALIRRLEEYKRFRETASAMKQFEQAAANLFTKLPEEYPLPPQETELVGLTLQGLTEAFLRIWARKPASDESPETNHYAPRDIHRDEHNVQECMLTLLKGVSSRGCLRFEETFSAAPSKEEVVTLFLALLELLKLGEIHVEQEGTWSEIVLYPGRGKDVDEYGESATEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJJ3</accession>
    <name>R7IJJ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TrpR like protein YerC/YecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51954">
        <property type="protein sequence ID" value="CDE51954"/>
        <property type="gene ID" value="BN770_00716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000831">
        <property type="entry name" value="Trp_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038116">
        <property type="entry name" value="TrpR-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013368">
        <property type="entry name" value="YecD_YerC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40080">
        <property type="entry name" value="PTHR40080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01371">
        <property type="entry name" value="Trp_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012508">
        <property type="entry name" value="YerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02531">
        <property type="entry name" value="yecD_yerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="104" mass="11679" checksum="F72CFF2AC8881065" modified="2013-07-24" version="1">MFEPRVKNGQTDLLMKALLSLESTDEAYRFFEDLCTIAEIKSMAQRIEVAKMLREHATYQEIARQTGASSATISRVNRALLYGANGYTAVLDAMENAAEKEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJZ1</accession>
    <name>R7IJZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000243">
        <property type="protein sequence ID" value="CDE51756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51756">
        <property type="protein sequence ID" value="CDE51756"/>
        <property type="gene ID" value="BN770_00596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436703" evidence="1">
        <location>
            <begin position="23"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="243"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="448" mass="50337" checksum="876213D16187B9E0" modified="2013-07-24" version="1">MKKYIACLLAAILLLTMLPASASAEGGMQACHRVTAKYTDSKQSNKSGIRLWSVKTALTSVDDEINGLAQAYADKIAPTLQAGKATGDKNSRLDVEIRHSKTGLTWMSFLVQARTTYHRDLIAQEFTSRTFDMTTGERILLTDIFPEGSEGWTMLREKLKAQINYYFPDETPDPDAVAQVLSDEGLRNLDFTLHGMSLVIHLSADAFYPEHHTLIETTLFYPDIREYMTEKAQIETDNLSYYKTVALTFDDGPTRTNSTKVLNSLMEVGAPATFFMIGKNMKPYADLVQRAHDEGHAVASHNWTHGDARKISAATLRAMPEKVNNALISIIGIPTRYDRVPYGVYPAMIKAKVGWSYIQWSVDTYDWRGRSTSLIMSKTKKQFTDGDIVLMHDIKDNTPNTAKVMAEWLYEQGYILLTVDELFAKDGVTLEPDTVYFRCDDGVTTIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IK98</accession>
    <name>R7IK98_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type transport system ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_00674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51891">
        <property type="protein sequence ID" value="CDE51891"/>
        <property type="gene ID" value="BN770_00674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="399"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="477"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="435"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE51891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="816" mass="91742" checksum="E492C043CA6B8DCE" modified="2013-07-24" version="1">MKIAKGIASVLKTIGLVVMAIAIVMSIYVVANDGAGWSTLSGALRSYQQNASVVTRAWFDKQYFSAMIDAASTKTLGGDVRQNRALTFYTTWVNELAAGQDALSKQKLDAFCADFDQNFDVDAYLTLYEQQESGSDSRLLAESFDYLNEVMTPAAPKGKPIKIATANTEPDVAAFYETFAQEHGEEAGSYLEFVETLTTMVRASVDAGNKPASMKKYLNALTFEDYAAALAEQRTLERVDTEDIRDEFAALVEQKKQGEAIDLAAFVQSKYEALQARYPSENLGTLDVFATTLLERVQSEDFDGSLSSLLKAVQVSVAAAPTYQTALKSLAETTVKKSDDSNAISLVIALWWLAARWVWLWLVGIVLLVIARVMNAITDKVTLARLEHAGIEEESDVLLRVNHLKQYFRSGDYINKAVDDVSFYIKKGEVFGLVGESGCGKTTTGRTIINLYDPTEGDVYFQGLRISSTQNGLPVLIRSLKNDFEEKQRQMKAALKEKTEKNPAQAAALKAEYDQKIKEMRKELKEKIRQARTNALESSVEKSKCVEKYREKRKAELTAAFEADSKTLSGQALEERRARYEQDMKVAAKDNIMTKMQMIFQDPIASINPRMTVREIIAEGLKIRGIKDEKYIDEKVYEVLDLVGLVREHADRYPHEFSGGQRQRIGIARAIVLEPDLIIADEPISALDVSIQAQVINLLNDLRNKMGLTIMFIAHNLSVVKYFSDRIGVMYYGKLVELADSDELFEHPLHPYTKSLLSAIPYPDPHHEKHRQRIEYKPLKEHDYSVNKPSLREIKPGHFINCNDEEFERYKKELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKJ8</accession>
    <name>R7IKJ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51823">
        <property type="protein sequence ID" value="CDE51823"/>
        <property type="gene ID" value="BN770_00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="246" mass="26866" checksum="62DFC61D760123A2" modified="2013-07-24" version="1">MKIALSSAPVKNKDIPHNLAAMTAAIAQAAADGADLVGFGESTLQGFDCLCWSYAADRDMALPLDSAPIRQLQDAARKYAAAISFGFIERDGDALYSSCAFIGADGEIIHRFRRVSVGWKEYRKTDAHYREGAHFEKFTYCGKTFAIGLCGDLWTDGRPEEMHALDADVVLWPVWCDYRADEWNSTIKHEYAEQAQKCGRRVLLINPCCADENAADAAAGGAVDFRDGKIQAELPAGNSGMLMITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKV7</accession>
    <name>R7IKV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51948">
        <property type="protein sequence ID" value="CDE51948"/>
        <property type="gene ID" value="BN770_00713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="167" mass="18348" checksum="3E34E74CDEF7E0B0" modified="2013-07-24" version="1">MSEQGTNQNQQLQVPPAQDFDTANFQGSMQEVLQENIGNYVLVDFLIGTSSLVSRQGFLYYVGTQFIVLYDSLNLRYVVCDIFSIKFVTFLLPGYQPGQIQTAAEFEMHPGTPNTQVVSEMTQASEGTSDSTARDADAAESFAARPAMTPAQAALAHAIRRKNPTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL33</accession>
    <name>R7IL33_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000211">
        <property type="protein sequence ID" value="CDE51317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51317">
        <property type="protein sequence ID" value="CDE51317"/>
        <property type="gene ID" value="BN770_00379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="126" mass="14757" checksum="59CDEC603A4FAAF3" modified="2013-07-24" version="1">MTRFPKEMTENGIHYTLHGDYYFPDLDLPDSPRQTIGRYGRMRKAYLEEHRPGLYERLLLSGKLYDHLAETDQVCRDRMEQIITRMAKAEGINEQLKASDQLGWVSRINSIHQSAEEIILDELVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IMI4</accession>
    <name>R7IMI4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51822">
        <property type="protein sequence ID" value="CDE51822"/>
        <property type="gene ID" value="BN770_00632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="8">
        <location>
            <begin position="200"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="322" mass="35151" checksum="D9C71763FEF0B39A" modified="2013-07-24" version="1">MRIALLATGGTIACRQTPDGLSPALHAEELAKSISCRDGVTLLPVDVFSMDSSNIQPEEWTQLAHAVDRAMQTCDGVVITHGTDTMGYTAAALSYMLLGQTKPVILTGSQLPLGAPLSDAEINLSCAIEAACQGVAGTYVCFNRKLILGTRAVKTHTLSFDAFDSVNRSLSGMVDSNGVHFLRPQKIDTPYQLRPEVDSRVFLLKLFPGTQPDVLDFIAQAGYRGLVIEAFGLGGLHYIRRNLVEKLRMLRQRGVRILVLTQCMYEKADLSIYEVGTQLLRTDVLSGMDLTTEAAVTKLMWALAQENTDELLTKNLCGEIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>R7I393</accession>
    <name>R7I393_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="8" type="ORF">BN770_00836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46354">
        <property type="protein sequence ID" value="CDE46354"/>
        <property type="gene ID" value="BN770_00836"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="301"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="381"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="468"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="553"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="651" mass="70626" checksum="ECA8584697C307CB" modified="2013-07-24" version="1">MPIEIAAHAGFCMGVRRAVESAVQVADSGVPSCTLGELIHNPTVVDMLRQRGIPPVASAEEAAGRQVLIRSHGVAPEVIKQLENAGCKVVDLTCPFVNKLHRVVAEDTGEDCPLIMVGEREHPEVKGTCGWARGKVYVVATAEEAAQLPEMDQAAAAVQTTFPPERWEAIVAVLRGRVQHLKEHNTICNATAVRQREAKKLAAASDAMIVVGGRTSANTHKLFEACKALCPRTILVECAAEIPPAFANIHSDKIGITAGASTPDGSLEEVATHMTDNENMAQSSDFTMDAIVATMTRIKAGQTVTGKVVQVTPDEVYVNIGYKADGIIKRSDLTQQDVKEGDELEAEIVKVNDGEGNVVLSQRNIVNRKAWEALVAKYDAGEYVKGVGKEAVKGGLIADVEGVRAFVPASQLAQHYVDKIEEFVGKEMELKIIEVDKQKKRIVASRKAVIAEQTAARKKAAWENLEEGAIIHGVVRRLTQFGAFVDVGGVDGLIHITDLSWGRINHPSEVVKPGQEVDVKILSLDRERERIQLGYKQLQPRPWDNAAERYPEGCIVEGKVVRIADFGAFVELQPGLDGLVHISQCAQNRVAKVTDAVQEGQIVRVKVLSVDTEKKRISLSIRQAAEDEFSFDDEAMGEEAPADAEEAPVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I485</accession>
    <name>R7I485_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46261">
        <property type="protein sequence ID" value="CDE46261"/>
        <property type="gene ID" value="BN770_00810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="338" mass="36768" checksum="2572B2CE46A154FE" modified="2013-07-24" version="1">MVTLKDIAAEAGVSITTVSNVVHNRKSRVSEKKVAKIWEIIEREHYVPSMSARSLANDQSAIIAMVTYITPRTTGSTVSDPFMSSVAASVEQRTREAGYYLMLRSAESVAALEGLIHSWRLSGLIMTGLFQDSFFDAVAKLGIPVVLIDSYVDDPNICCVGLEDEKGGYLATKHLLENGHRVIAFASPPISPAGVIELRLQGYRRALAEYGVPYDPALVFTQEISVQEGKKLGHQLSTRPEITGIFASADILAAGIMSGLHECGVSVPRDKSIVGFDDHYISQLAIPGLTTIHQDSEKKGTLATEMILAQLRKEEIAQKKVILPVHLVERGSVRNING</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I496</accession>
    <name>R7I496_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BN770_01004</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="12"/>
    <dbReference type="EMBL" id="CBJB010000023">
        <property type="protein sequence ID" value="CDE46704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46704">
        <property type="protein sequence ID" value="CDE46704"/>
        <property type="gene ID" value="BN770_01004"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00533"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDE46704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="272" mass="29014" checksum="D7B44F7E3E5F1E16" modified="2013-07-24" version="1">MRQKTIVGLIMAAGAALMIAVGGWVMALIVLVLICFGVQEEFHALAQAGHRPVAWPTWVGMIVSIPLTLLIGTKMILPVIMAICLMTMICVIFRSEPKLDDAVLSMLPMLTVALPGMSAISFTHIEPKALQVTLITLMIGIPCMADAFAMWVGKAVKGPKLCPTVSPNKTISGAIGGVVGALLTSILIGVVAYLVAGEARPLLPAWYVYLILGILGGVVGEMGDLFFSLVKRHCGMKDFSNLFPGHGGMLDRLDSVLFMAMLMLCYRLMAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4R1</accession>
    <name>R7I4R1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron(III) dicitrate transport ATP-binding protein fecE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46476">
        <property type="protein sequence ID" value="CDE46476"/>
        <property type="gene ID" value="BN770_00888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="130" mass="14694" checksum="BD9AC83F3EBCA6D5" modified="2013-07-24" version="1">MNIHESAEDYLEAILRLKEAKGYARSVDISLLLGVTKPSVSVAMKRLRENGYLTMDADNLITLTPAGMEIARSIYDRHKTLSSFLESLGVDSDVAREDACKIEHDISEESFTAIRKLMQEREQHPENPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4U0</accession>
    <name>R7I4U0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46238">
        <property type="protein sequence ID" value="CDE46238"/>
        <property type="gene ID" value="BN770_00794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="365" mass="42407" checksum="A10DDF7CAC65A1E5" modified="2013-07-24" version="1">MDIQQYFQRFLANYTPYKKYWNYEDGCVLKGCIDLYHATGDVLYRDFVLDYVSAYVAADGSIPNYEMRQYNIDSINSGKALFFALEETGEERYRKAIEFHMQRLREHPRCQCGNFWHKQLYPNQIWLDGLYMAQPFYMAYEAKFDGMAHVADITQQFQNVRKYLYNPEKGLNYHAYDEARVQFWADKETGCSKNFWLRSTGWYLMALVDCIALCSEQLYEHYRALVDIFRESIRGVLPYRAEDGLFYQVIDHPEAEGNYTETSGSAMIAYSLLKGVRIGVLDAEKYLPIALDVFEKLAANKLRTEEDGVVRLTDICWVAGLGPDKNPQRDGSVAYYLSEPKKSDDSKGVGPFIMAYSEYLRAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I514</accession>
    <name>R7I514_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000019">
        <property type="protein sequence ID" value="CDE46581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46581">
        <property type="protein sequence ID" value="CDE46581"/>
        <property type="gene ID" value="BN770_00948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="376" mass="42064" checksum="535C61B23FD28322" modified="2013-07-24" version="1">MKKLLALLMIWLLLPIAGAEEAYTMQEGSLILMDGAGRKCQPIAMKPDFPEALLADADISGAIQLNLPETLLPYVSDELTGGETLTALYCTTKLIAMHTVDAADGDVLRVAYRTNLGNYVIRKVIGTPFSFDRYHGGVASILLCVDEITYCMTCENGYLTLREVWNGAGGIGIKRHALYDLQACVESAGGNAGFRYGNHPYSDVTDLPFAEFPTTYEEAMQHLDRTNWAVVNNPNPADRLYLRGKASKEGRNLGKFYNRTPVYVEEIRGDWAYVRIGRATTGYMMTKYLTFGEDADKVECAFPQLEVREEYRLNVADETTYEFEVLDEPKKSAPYTRWHSGDNWGVIGIKGNYYIVMNDNENVCYIPQSHLWAGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5E7</accession>
    <name>R7I5E7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative bacteriocin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46855">
        <property type="protein sequence ID" value="CDE46855"/>
        <property type="gene ID" value="BN770_01054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28701" checksum="40B1B9D291C658BA" modified="2013-07-24" version="1">MALLEAKNIRKVYATRFGGNQVQALTDVSFTVDEGEYVAIMGESGSGKTTLLNILAALDRPTSGTVLLDGKDISAIRENQLAAFRRDQLGFVFQDFNLLDTFSLKDNILLPLVLQGMNWREMEANLLPIANQLRIANLLEKYPYEVSGGQKQRAAVCRALITHPRLILADEPTGALDSRATDALLDVFQQINQTGQTLLMVTHSLKAASRAGRILFIRDGQVYHQLYRGEMTNEQFYEKISDALTVMTRKDAMDGEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5U8</accession>
    <name>R7I5U8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 3 N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000027">
        <property type="protein sequence ID" value="CDE46861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46861">
        <property type="protein sequence ID" value="CDE46861"/>
        <property type="gene ID" value="BN770_01060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25837" checksum="0277C6711B1B6B34" modified="2013-07-24" version="1">MLTNVIGREVIQGCSDKGIINGPKHMGFNDQEHNRAGISAYMTEQKFRETDLRGFEGALSDAFGMGVMIAFNRIGATNASHHVGMIQKIVRGEWGFKGLISTDMMNNYLYFNAESMVMAGITQVADFAADNSHINLGEGGVDAVWPHISLATVSKDSNLVEQARENLKYQLYIFANSAILNISTQRVNTWWDTALTVTTYASSILAVLFFLAWVVLTLLPEKKPVVVRVENKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I687</accession>
    <name>R7I687_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000044">
        <property type="protein sequence ID" value="CDE47369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47369">
        <property type="protein sequence ID" value="CDE47369"/>
        <property type="gene ID" value="BN770_01223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="258"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="618" mass="70495" checksum="9BF6598A9E7B89A4" modified="2013-07-24" version="1">MQPEINQEAIARMLDQVQKPTRYTGGEMNTQLKPWDSAKLHFAFCFPDTYEVGMSHLGMKILYAAMNQQPDMLCERAFMPWVDMMDLMKQENVPLFTLESRSPLSAFDVVGFTLQYEMSYSNILAMLELGGIPLLRENRREEDPIVVAGGPCAFNPEPLADFIDAFMVGDGEEQILDLNRVIMQGREEGASRMTILKRLCAIRGVYVPALYDVKYNADGTIASMKPNCPEAPEKVLKAIIPDLDKAFYPTEIPVPYMEIIHDRIMLEIMRGCTRGCRFCQAGILYRPVRERSLEHLVELAQQLENTTGYEEISLSSLSSGDYTCLAELIRELIRRLDEKHVSISLPSLRLDSVLKDSLEATQKEKKTSLTFAPEAGTQRLRDVINKGVTEEDLMSKVSDAFHGGWSSVKLYFMMGLPTETTEDLDGIADLAKKVVDAYFAVPRGERAKGLRVVCSASVFVPKPFTPFQWEPQDTQEMVREKQSHLREKLHIKGVTFNYHESDLSYLEACFARGDRRMGQVLLRAYQKGCMLDGWTELFKYDMWREAFAELGIDPAFYAYRRREKDEIMPWDVIDCGVTKEFLWREKEKAEKAQTTKDCRKGCNGCGLQRFKGVCKYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6A8</accession>
    <name>R7I6A8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47394">
        <property type="protein sequence ID" value="CDE47394"/>
        <property type="gene ID" value="BN770_01239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="158" mass="17992" checksum="7727925F1734120A" modified="2013-07-24" version="1">MATISIIRVENPEKKAEISAHILHALPDWFGLPDSTQKYIDDSRNMPFFAAVREGQAVGFAALKETSPCAGEIYVMGVLPEYHRSGIGRQLFAAIRAEAIARGYRLLQVKTVQTGHYEEYDRTNDFYQRMGFLPLECLPTLWDEWNPCQVYVLPLQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6S2</accession>
    <name>R7I6S2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="6" type="ORF">BN770_01167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000038">
        <property type="protein sequence ID" value="CDE47176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47176">
        <property type="protein sequence ID" value="CDE47176"/>
        <property type="gene ID" value="BN770_01167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="66" mass="7590" checksum="72B5C1EC31271CAB" modified="2013-07-24" version="1">MPKQKSHRGAAKRFSFTKTGIVKHKQMNANHQVRLKTTKRTRHLRADGIVDNAAEAKTIHKLLPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6W9</accession>
    <name>R7I6W9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="10" type="ORF">BN770_01172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000039">
        <property type="protein sequence ID" value="CDE47221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47221">
        <property type="protein sequence ID" value="CDE47221"/>
        <property type="gene ID" value="BN770_01172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L9_C" evidence="9">
        <location>
            <begin position="64"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="150" mass="16195" checksum="90A90D70405DDC00" modified="2013-07-24" version="1">MKVILLEDVKGVGKKDQIVNAADGYARNFLFPKKLAVEATPGAMKGVEKMRKAEAEREAQRRADATAQADALRGKVISMSVKCGAQGRLYGSITSAEVAEQLKAQHGVAVDKRDIKCENIRAVGDVEIEGRLYKDISAKMVVHVEAAAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I754</accession>
    <name>R7I754_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage V sporulation protein AB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000057">
        <property type="protein sequence ID" value="CDE47684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47684">
        <property type="protein sequence ID" value="CDE47684"/>
        <property type="gene ID" value="BN770_00102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020144">
        <property type="entry name" value="SpoVAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13782">
        <property type="entry name" value="SpoVAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="136" mass="14050" checksum="645C94E58DE889DF" modified="2013-07-24" version="1">MNSVLAILIGLMSGAAMSVAVSSVWCVLHLPARIQHLLHAASPRMMGLALLSGLMLAALHNALRWTLGLPGVFGVVAMVVGGMFVGMVASALGEILEVAPVLMRRFRLGDVSGAVRVTILLAKTLGAIIASIAITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I766</accession>
    <name>R7I766_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000042">
        <property type="protein sequence ID" value="CDE47311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47311">
        <property type="protein sequence ID" value="CDE47311"/>
        <property type="gene ID" value="BN770_01209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenine_deam_C" evidence="2">
        <location>
            <begin position="80"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="232" mass="25140" checksum="7544CEFC80544E9C" modified="2013-07-24" version="1">MLDNLHDVNVEMVFKRGKLVYDGHEVEIAAPDIDPDILAGVLDTFHLPDVTPEQLRIGRAPLIGLIDGQIVTEDLGHAEGVDNGICQMTVCERHHDTGHVASCYVRGYGIQRGAVATSIAHDSHNIIACGVSPEDIAFAVNELKKMHGGIIVVENGQVQARLPLELAGLFTDRPLPEVNEKLEHCKAAAWAQGVNRGIDPFMTLSFASLPVIPALRLTTKGVFNVNTLTFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I772</accession>
    <name>R7I772_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative virion core protein (Lumpy skin disease virus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_00848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000010">
        <property type="protein sequence ID" value="CDE46367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46367">
        <property type="protein sequence ID" value="CDE46367"/>
        <property type="gene ID" value="BN770_00848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Band_7_1" evidence="5">
        <location>
            <begin position="30"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="4">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE46367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="357" mass="38740" checksum="25009D30B4834177" modified="2013-07-24" version="1">MGIFDSIGNIVRGQLIDVIEWTDSTNNTIVHKYDMNGKEIMMGAQLTVRESQVAIFVNEGKLADVFQPGRYELSTANMPVMTALKAWKFGFNSPFKSDVYFVNTKQFLDCKWGTTNPVMMRDAEFGMIRLRAFGAYSFRVADPEVFLREVFGTSSEYTVQDVEGQLKRTLVSGLSDAIAESKLPALDLAANYDEIGDYALKTINPRIEKLGLTLASFVIENISLPEEVEKTMDKRTSMGVLGDMNRYTQYQAAEAMREAANNPGGMAGAGVGMGAGVAMGQAFAQAMQATQQPAAPVQQQPTAQKGSFCANCGEQLTPGAKFCPNCGQKQEAANVCPACGQKVQPGAKFCANCGQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7I1</accession>
    <name>R7I7I1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000048">
        <property type="protein sequence ID" value="CDE47451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47451">
        <property type="protein sequence ID" value="CDE47451"/>
        <property type="gene ID" value="BN770_01253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="SPOB_a" evidence="6">
        <location>
            <begin position="228"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="5">
        <location>
            <begin position="319"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE47451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="423" mass="47700" checksum="500A3304B5665891" modified="2013-07-24" version="1">MLPAAVMVLMSVWEQLLSPKRTACQAMLFILLACASGAAVCCWQGWVTNTLLLPFMALAFVLFRRALKPNVSVSQSILLFLSPATVAAVALMLSVCLNARREVTNVQPIYLLSTVLLNFGIESLLAIVYALVAVPWLRWLLREYQVERVWRVVSPIPAICIAFIIFIMPQDPATVLVNRMQRVSIVALLMAMMAMLLLLYQFYRMAQESVRNLTLIQENQMLELESRRYAQLREYMAQTRRLRHDFRQHLHVIAGLTESGKMEELRAYLKEYESEFVDAHATFCANGAMDAIAGYYAATAAQKNIPLAWQLNLPEKLPMREADLCMVLGNLLENALRASERLPEAMRRVSVICHMLSPAMMGLIVENRYDGQLSRREGKLLSTSHPGFGTGLLSVETVAKKYHGQMTVETENGVFRVNVLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7I2</accession>
    <name>R7I7I2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46482">
        <property type="protein sequence ID" value="CDE46482"/>
        <property type="gene ID" value="BN770_00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="265" mass="29077" checksum="9234D982BDBF6E03" modified="2013-07-24" version="1">MRSTEEMLQAAVQQLQTAEQARLTSETDPARRQLLHLLYAREAAALQSMTLIRAEIPAAQKRDWKPLIFPLAAAVLNLGALALWLTLPNCVTPENSGWMGRFALCIVAQSVSLCAAIGSIVSAMRRKPPKPVVVADEPELRRRLVEAEGRIALDAQTIEALFAQESVTIISTGAETAAELYASLYEMAQDARLDGDANQEKALSWPLSNAKRLLNAVGCEAVDYTPETAMFYDVMDADITQQRRPAIVQKADGIVQQRGLYLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7K1</accession>
    <name>R7I7K1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46502">
        <property type="protein sequence ID" value="CDE46502"/>
        <property type="gene ID" value="BN770_00911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="83" mass="9185" checksum="0250E3FE99E6A7A5" modified="2013-07-24" version="1">MIVKPITFPNHQPLNRTLAAQVVQTASRFDARVMIRRHQKVVNAKSMLGLLSLDADEQNEMFLVCDGADEEAASAAVLPFFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8I3</accession>
    <name>R7I8I3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">birA</name>
        <name evidence="4" type="ORF">BN770_01358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000064">
        <property type="protein sequence ID" value="CDE47791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47791">
        <property type="protein sequence ID" value="CDE47791"/>
        <property type="gene ID" value="BN770_01358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="72"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="2">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="322" mass="34980" checksum="7019B40FE02E97E2" modified="2013-07-24" version="1">MNDILAILSGGDYVSGEKISQELGISRAAVWKRIAQLREDGWQIEAAGRRGYRLIPGDSINPIFWVNQLTTKTLGRAINHYEHTITSSNTLVKQMAVQGAPSGSLCLCECQTAGKGRLGRTWSAPAGQAILMSVLLRPKLPPKNAPLITLATAMAMAHAVREVAGIDAQIKWPNDLVFSGKKLCGILLEISADLDQIEYVVVGTGLNVLRGAYPPELSDRAAALEEFAEPPVRREIVVHYLKALEDNMTLLEEHGFPGIQEAYRRHCCTLGSRVHVIGTEIDFIGTAEDIDETGALLVRDESGVLQRVLSGDVSVRGVMGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I936</accession>
    <name>R7I936_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase-related glycosidases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000060">
        <property type="protein sequence ID" value="CDE47768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47768">
        <property type="protein sequence ID" value="CDE47768"/>
        <property type="gene ID" value="BN770_01350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="388"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE47768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110182" checksum="7C62E65AA4131020" modified="2013-07-24" version="1">MSAAKTGMKKSTYLIIWTLVIALLCSAVGVANYEALYWDSALTLYFGEVGVKNVSTVTFDTDDHAQVANLIVAEGAVLLKNEDNALPMKGGKISLFGIDNKSGVLQKVLEDEGFTVNPTLAAFYAASSHSSGAGSLSAGNGSETGGWVIDEVPQSEYTADVKASYKDYNDAAVVVLMRTGAEGNDLPYDMSRYGGSADENYLELNKDEKELLAEVHKAFDKVIVLISSANAMQMDFVDKAEYGIDAVLWYARPAGGIGSIAKILSGAINPSGRLVDTYVHDNMSSAAMQNFGDYRYVNEDGSLSGYSYVNYAEGIYVGYKYYETRYEDAVLKQGNAGDYDYAATVAYPFGYGLSYTDFEWSDLKVDWDGDLCTASVTVKNTGFTSGKDVVEFYVQSPYIPGGVEKAAVALAQYVKTSELAPGESQRVSVTFSKQDIASYDAKDAKTYVIDAGDWYVTAAHDAHEAVNNVLAAKGKTTADGMTANGNTAMAAKYTVSERELLNKDAVSGAEVTNQLDDIVYADDTVYLSRSDWSVMDNNGLEYATGVAKGVSNVGNISGDVPTYVISDDLRAKFELKGFAASLNPTDPTDAALYPGKEAYTYGAKNNLKLIDMVGLDYNDPKWDLLLDELKLSEMHQLFNKSGWGSLAVESVGKPKTYEYDAPHGIANFLTDAVIYSYPCATMTAATWSQDVQRIYGNAIGEDAIASNTEGWYAPGINIHRTPFGARNYEYYSEDAVLTGLCSAAVCAGVEAHGMHAYIKHFVMNDADTNRAANGCVAVWGTEQATREIYLKPFQYSIQKGGAQGIMLTMCRVGWQFTFGSYPLMSAICRNEWGWHGCYITDYTTTMKGAGADQYLAAGGTLIHATAEQSLSDVKSGWCRKLIREAVHQILYNTANSLAVDPAYAAMLNQADDAAEETTAPAVEEQKGFLYGMAWYKVVLYGFDILMALVLVFMAIRVYSKVPMTEEQFQNRKRMSKKGKRIMWIVIAVAVIAIAVVFYLWAWPLLVKAFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7I970</accession>
    <name>R7I970_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MutT/NUDIX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000065">
        <property type="protein sequence ID" value="CDE47808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47808">
        <property type="protein sequence ID" value="CDE47808"/>
        <property type="gene ID" value="BN770_01369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE47808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="152" mass="16871" checksum="BFEEA69C3E7B854E" modified="2013-07-24" version="1">MHTPAPIELMNVCLLRDDANRMLVQDRTDPSWPVLCFPGGHVEIGETCADAVVREMQEETGLTVVSPRLVGIKEWMKHGGQTRALVLCYEAAAYTGTLTSSAEGENRWMTRAEIAAHPRGKSLLDFLPVYENPDVTSMFYAPDGDGWTAVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I977</accession>
    <name>R7I977_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetaldehyde dehydrogenase /alcohol dehydrogenase AdhE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48051">
        <property type="protein sequence ID" value="CDE48051"/>
        <property type="gene ID" value="BN770_01510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="116" mass="12707" checksum="F190B9B67787C8C1" modified="2013-07-24" version="1">MAKEYPIVDNVESFEAALARVRAAQKVYATYTQEQVDKIFKAAALAANNMRIPLAKMAVEETGMGVVEDKVIKNHYAAEYIYNAYKDTQTVGVLERDEAFGMMKVAEPIGVVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9A6</accession>
    <name>R7I9A6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ORF">BN770_01390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47853">
        <property type="protein sequence ID" value="CDE47853"/>
        <property type="gene ID" value="BN770_01390"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE47853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="293" mass="31701" checksum="025063BB8ECDAFB7" modified="2013-07-24" version="1">MKPLFTGTGTALITPFKNGEIDWDALDNLVESQIAGGVSALIAAGTTGEPSTMTWDEHIEVIRFVAERAKDRACVIAGTGSNCTREVIHAANVVKDFGVAAQLVVTPYYNKSTQEGLVAHYTEIAEKTSLPIVVYNVPSRTGVNILPATLEKICRLPQVVAVKEANPDVVQAMEKINLVGDDAAFYCGNDDLTIPLMVLGFQGVISVLSNVMPAETSKMTSLALSGNWAEASKMQRDLLPMVKALFCETSPIPCKAAMSMMGMCRNELRLPLIPMQEANQQKLADIMRGWKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9G6</accession>
    <name>R7I9G6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-galactosidase/6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000073">
        <property type="protein sequence ID" value="CDE47928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47928">
        <property type="protein sequence ID" value="CDE47928"/>
        <property type="gene ID" value="BN770_01438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="9">
        <location>
            <begin position="200"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE47928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="440" mass="48304" checksum="3B2B47F9ECCA9C23" modified="2013-07-24" version="1">MPFKFAFIGQDIPMHLPFLLVDFLYAGKEDGILAVEEKNAAMRDVLQHYAEAIVYASGRKAQIIVSGNRQEVLMGADCVVYAGDCMAATRFRQDQDALGGVKEDDPGLSDQARVHGGIEGLMHTLRQGEVVLDLCRNMRSACPKAIVVTLGQPVARTTQLFLGAGFQAYGLDDAAYRGNTVPRLAKALFRKEDAVEAVTAGLPGFSFLVSLREKGKNVDLIPALRQMAEEDKLGRLTHRWLGWYDAIAVGDVMRHAEFLAAEEDYIPEENPAFGESIEKRKERIAHMNTIGHEGAKTPDGMTAQLMLLKDTPPTRPVRLALAILRKETAVIPAVAQQNRGELPQLPPNAIIESDLHLADGLVQPQGIRVPAPLAEIMMDIDETNRLAALAATGDWSALREAVEVDPALEGLDRLYVQEVVRRLVQLNGDVLSRLVDDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9H1</accession>
    <name>R7I9H1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000111">
        <property type="protein sequence ID" value="CDE48534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48534">
        <property type="protein sequence ID" value="CDE48534"/>
        <property type="gene ID" value="BN770_01726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="395" mass="44881" checksum="ABE21904C8EA6EA9" modified="2013-07-24" version="1">MGHVQINLFGSFHVERDGKSVDEQLARSPKGMLLMQYLILAPRQTAEAKTLMQVMWPEENSTSPDTALKTLISRQRALLREISPELAMCLVTVRGGYRWVCPPEVSVDVLEFEEMLARMKLPGGATPSEEMLTRMLVLYQGRLLADQQPQPAWLYNRSERLHQQFLQTVDSRLAQLQQAGHVHRYVALVRRAIDADPTNEALQQRLIEGLRQTERDTDADQQVELAARLNSAARDEMMADYYDRIQRANSALETGLVQFKEELMRGEDNNRAIVCDRRVFRSLFCLQRRGMERTGGHALLGILTLTELDPTSEKREAALNGLVKIMLLNLRRGDVITRLDESTIAMFLPNADESAANIIIDRLKRSFYLQFPSTGRTLSCAISAISVEKTKPEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9P7</accession>
    <name>R7I9P7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48023">
        <property type="protein sequence ID" value="CDE48023"/>
        <property type="gene ID" value="BN770_01499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436303" evidence="1">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="176" mass="18997" checksum="33E38C1F8118ADC7" modified="2013-07-24" version="1">METNMKKLLALLMALMMCCTAFAFAEEEAEVPAVEMNVSFEAQTVALGETGLTMQIPADWAVQEVPAGTENAENILLFAVNADQTVSITVQKSAMTFETLLQGIQDAGATEEMLAELYVNENYCLMYTPGDTVLALYAFLDDETVLAVTFQVASKEVGDALENMPLEIFGSLAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9T2</accession>
    <name>R7I9T2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">BN770_01188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000041">
        <property type="protein sequence ID" value="CDE47262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47262">
        <property type="protein sequence ID" value="CDE47262"/>
        <property type="gene ID" value="BN770_01188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="124"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE47262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="431" mass="48280" checksum="B2863BF5BE1A070E" modified="2013-07-24" version="1">MSEWVLEVSEVNEYVRQLLQNEPALRKVRLRGEISNFKRHSSGHWYFTLKDERCRIAAVMFRQNAMRMSIRPMDGMSVIVSGQVGLYSEGGSYQITCDSMRPDGIGTLYQQFEALKNRLAAEGLFDEEHKRRLPYRPKKIAVVTSETGAVLHDICMVSRARDPGVPLVLVPVQVQGAGAAESIAQGIRRAAKIPEVEVVIVGRGGGSMEDLWAFNEEIVARAIYDCPIPVISAVGHETDFTIADFVADRRAATPSNAAEMAVPDLREILAGLDGMRQHLQTALSQHLQETRLTLMTLEKRLAACDPNQRLTALEKRLGGAKMRLEHQMSQRISALTPRLGMARIRLDSAAEQNLQRKMERLHRQKLHLQALNPEKVLERGYALVLDGGRVLPDRAAARTHPQMTIRFRDGEMRVMQPNKEGAYGSEKEADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9T4</accession>
    <name>R7I9T4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48063">
        <property type="protein sequence ID" value="CDE48063"/>
        <property type="gene ID" value="BN770_01522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="349" mass="38397" checksum="4C364C2BD3123F66" modified="2013-07-24" version="1">MSNEAPQQTLKQPVQPPMQIELQNVKKVYPVTGGEVVALDNISLKIRKGDIFGIIGLSGAGKSTLIRCVNRLDTPTEGKILIDGQNVPDMNKQQLRQMRRKVSMIFQQFNLLMQQTVAKNIAYPMECIGVPRAKINARVKELLEVVGLESKAKAYPAQLSGGQRQRVAIARALASDPEVLLCDEATSALDPMTTQAILRLLQKINREMGITIVVITHEMAVIRQICTHVAILDGGVIAEEGSVDDVFTHTRSEAGKRLFGIVASENHEQVQEKPAIRIVFNGETIAEPIVADLILHLGVPLSIRSADVHTLNGAQYGQLLISRPDDPMVCHRAIEYLKERGLTVEEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA50</accession>
    <name>R7IA50_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48739">
        <property type="protein sequence ID" value="CDE48739"/>
        <property type="gene ID" value="BN770_01798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435685" description="Lactamase_B domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="51"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="296" mass="32982" checksum="C36277598AC7A41B" modified="2013-07-24" version="1">MKRKLLLMLLCAALGLGAAQAEVYRVENETDVPADWAEKDTLRLTCIDTNRSDAMVLQSGGEAMMVDSGEGRYRKRVYATLDGYGITELKYLLNTHCDDDHLHGFIYLMYSDLYQVDAFLSPNTTTYVDEEGYHQQAVKATGTKNIPYVQIGDGDELTLGNAKLTIFRCPLPTGQNNRSAACMVQFGDSRAFLTGDIDNETMQWYAATYGEKLRCDILKAPHHGLATIPDSFVEQTQPQVLFVPNRSALSTKVTAGWVKNHMPGAALYFSGDGTVTMLTDGTDWYIWQEPNYVDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAE2</accession>
    <name>R7IAE2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterial capsule synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000113">
        <property type="protein sequence ID" value="CDE48565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48565">
        <property type="protein sequence ID" value="CDE48565"/>
        <property type="gene ID" value="BN770_00143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448116" evidence="3">
        <location>
            <begin position="21"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="4">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="412" mass="45478" checksum="D88D6ADC55E30CBA" modified="2013-07-24" version="1">MRKITCLLLLLCLLPSFALAEKTITLTFTGDITLGGEDYLRTAEDSFFAVYEREGAGYFLKNFADFFAEDDLTVVNLEGVLTNNNALYPRDKGKGDDGYWFRGPAAYAKVLSAASVEVASLANNHAFDYGAQGFRDTIAAVEAEGLGWFGTYNKNRNPETEKFYFYTKDGVTICLMSLLWDDYNPQDPNGNGAYLRQQITEIKQSGQADAVIAILHGGQEYGRHRTKPQTIFTKMAISAGADLVICHHAHVVMGMDVINNRSAFYSLGNFCFGGNRKAYQENKNRTPAVQDAAPALMLRAVLTFDDDGTYKGQQITLYPVQTTGIDRAAGETVQVNNYQPKFITGPLAAHVLHLMQIDMNYDASKTPKYSNAESINKTLRALVMAREEELAAMDSSEGMEALTLPFLPAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAL0</accession>
    <name>R7IAL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000111">
        <property type="protein sequence ID" value="CDE48531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48531">
        <property type="protein sequence ID" value="CDE48531"/>
        <property type="gene ID" value="BN770_01724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="130" mass="13568" checksum="FDB4E088DE39971D" modified="2013-07-24" version="1">MHRGHPLLCGTLLGLTWTLLSLLFQGVDWLAAWSLEREGAALLGMTAIGALIAAVPKLLRNRGSYWAHESALGCAGAFLCGVGMMMGLHLAGSGRIVSAMLEGSTGAFGFVIMAWIAGCVTALLAGRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IAX3</accession>
    <name>R7IAX3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_01762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48641">
        <property type="protein sequence ID" value="CDE48641"/>
        <property type="gene ID" value="BN770_01762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE48641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="145" mass="15914" checksum="9D1CB8EC840ED612" modified="2013-07-24" version="1">MSEQQKKGRLGEVIRFVVTGGVCFLIEQAVLSLLKEIFGLDVNIGTPIAFLVSVVANYLLCVKWVFPGADGSGGKTKAGFVLTSGIGFFLNWGIMALLTALFGQDSILLTLFGIQLKVYHLNKAIATLLVMVWNYFTKRLILKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB18</accession>
    <name>R7IB18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="10" type="ORF">BN770_00151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7 8">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CBJB010000135">
        <property type="protein sequence ID" value="CDE49104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49104">
        <property type="protein sequence ID" value="CDE49104"/>
        <property type="gene ID" value="BN770_00151"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_B">
        <property type="entry name" value="OMPdecase_type1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25219" checksum="B438295DBDA902BF" modified="2013-07-24" version="1">MAKDVIIALDFENKEKTLAFLDQFTGRKPFVKIGMELFYAEGPDIVREIKARGHKIFLDLKLHDIPNTVKKAMKVLSKLDVDMTNLHAAGTIAMMEAAKEGLTKEDGTCGVLLAVTQLTSTSEERMQQELLINATMPETVKKYAQNAKAAGLSGVVCSPLEAALVKEACGQDFLTVTPGIRFADGDVGDQVRVMTPAKARLGGSDYIVVGRPITAAADPVAAYERCVKEFLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB60</accession>
    <name>R7IB60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48800">
        <property type="protein sequence ID" value="CDE48800"/>
        <property type="gene ID" value="BN770_01819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="336" mass="36826" checksum="CA288B7E290DCFC3" modified="2013-07-24" version="1">MSGITMRDIGRQLGVSAVTVSKALAGKSGVSEEMRQKIIRRASELGYVNPNAPQTTPTSGLDVGILIPENFFSVVSFYATFYKQLVQALTDAGHFGIMELVTHDMQTALTLPNLLRSRHVDALICLGQLTSPYMQLLTRQEMPVICLDFHDPFVTTDAIVSDNAFGAAQLTYWLIEQGHRDIGFVGDIKATSSIMERYLGFLSAMLMKDLPVRPECVFSDRSPEGNTFHTFQLPEKMPTAFVVNCDMSAQALITDLQSRGYRVPEDISVVGFDDFCPTAGNTPPLTTFRVNCPAMCRMAVKLIGERCAGDRKTVGRVVIGGECVFRDSAAPVSVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBD5</accession>
    <name>R7IBD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000123">
        <property type="protein sequence ID" value="CDE48895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48895">
        <property type="protein sequence ID" value="CDE48895"/>
        <property type="gene ID" value="BN770_01852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="113" mass="13070" checksum="A5C31790FC8C2594" modified="2013-07-24" version="1">MWAILEQLRDHATTIVGLVTALTLMYGWFRKPMKQLITREQQQEEDLAILTWAFLQNAHDNYTRQGWCTAAEKEQVLNMHKSYAAKGRNHLSASYEQDILALPETPPEGRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBG7</accession>
    <name>R7IBG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000116">
        <property type="protein sequence ID" value="CDE48653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48653">
        <property type="protein sequence ID" value="CDE48653"/>
        <property type="gene ID" value="BN770_01772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="118" mass="13331" checksum="04A335D91AE60D04" modified="2013-07-24" version="1">MDDMQKDFSPAADADSIDDMADDMIEMTDEEGNTTLFKILDYFFYNGDEYAILTDSIDEGTTGADRVDCYVMKIVPTTDESGEELEEFVPVEDQKLEAKLMEIATLKLNDDEQADDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBN5</accession>
    <name>R7IBN5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47917">
        <property type="protein sequence ID" value="CDE47917"/>
        <property type="gene ID" value="BN770_01430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE47917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="51" mass="5610" checksum="22059E0613852A8A" modified="2013-07-24" version="1">MVLPLDPAKGSSTLWTPFRAIELVTTAYFFRVFIGGTQGALPLDPAREFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC25</accession>
    <name>R7IC25_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48838">
        <property type="protein sequence ID" value="CDE48838"/>
        <property type="gene ID" value="BN770_01838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="204"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="401" mass="43989" checksum="93EF9F1164FC9837" modified="2013-07-24" version="1">MSAMKQAENRSARQVTLHLTLPILVTLTLLTAAFSTGSPVFLMPALLIALLCLSGIYGVFRASATLEVSSRASTERVQRGEDVTLNVQVKRRGWIPLAPMWLELSGVNGANSTASGTQMMQLRPGRSQALELSFHAAHVGAIHPGVQSVMLSDFFGVCTIRQKPNMDGGELLVLPQLFDIAPLRLSSGEMGTEAMARASEDVTNPTDVRTYQPGDPMKKIHWKLSARKQEALVRRFEDPVQPDALVLLDCAEPPKQADSEEDADLRDALIETAASVMVQAAKAEHPARLPLPGAHPVELDKDMGLKMLLENLARADFSNPEPFAKVLLLEMRRMRKVGCTVVITARLDSQMVDVMLSMRRMGPNVRLYLVTQTPEDARLMPMILKLQEVGVEVGYVKPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IC40</accession>
    <name>R7IC40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000078">
        <property type="protein sequence ID" value="CDE48072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48072">
        <property type="protein sequence ID" value="CDE48072"/>
        <property type="gene ID" value="BN770_01527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="316" mass="35745" checksum="A6FB7BD483E29637" modified="2013-07-24" version="1">MQSTKAIVRRDLTGRSTMRWGTYLKRYGTLYLLLLVPLAFFIIFRYVPMSYILLAFKKNNILKAPWLLDWAKNGGWEWFIKAFNDKNFIDALKNTIILNLLDLVIGTPMPILMALLLNELAFPKFKRVAQTVLYLPHFLSWVIISSLSLRLLATNDGLVNQIFGTNIAFLGTENNWRATYIVLGIWKECGWNTIIYLAALTGISPELYEAAEVDGASRLRKIWHITLPGIRSTIIILLIMNLGRILGSEFDRPFTLSNPLVEGASKTISIFVYERGIKGNQFALSTAVGLFQSVVCVIFLLASNTLAKKFDEPGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICB9</accession>
    <name>R7ICB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000081">
        <property type="protein sequence ID" value="CDE48152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48152">
        <property type="protein sequence ID" value="CDE48152"/>
        <property type="gene ID" value="BN770_01564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="128" mass="15041" checksum="BD07C4A354A516A1" modified="2013-07-24" version="1">MVTFQRQRERQAEELLLTPGEMAARCDWQQVRRMREEMPDDVCSTHAWYQNCDALDRELRAQYPMIGALETAVRAYGYAMENSTRPRVQETMRWRLTLDQFGILAQVLARHGLIADVREALEYFAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICG8</accession>
    <name>R7ICG8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Eco47II restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49196">
        <property type="protein sequence ID" value="CDE49196"/>
        <property type="gene ID" value="BN770_01934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019057">
        <property type="entry name" value="Restrct_endonuc_II_Eco47II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09553">
        <property type="entry name" value="RE_Eco47II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="29952" checksum="24893428A251F8F7" modified="2013-07-24" version="1">MWPLTFITEKDFTEHVKATIEKYGEKLEPFSLEKFNSNLIDPIKLIFDKMVYQYSWEEIVKNEIFRQRDKSNNNDIGYFHQRMFQYIKNCEVPKAGWDVIYRNPNGIQTAEGEKVHTVYVEMKNKHNTMNSTSAAKTYIKCQNQLLNDDDCICCLVEAIARHSQDIKWVASVDGKRVQHKRIRRVSMDRFYQMVTGQQDAFYQMCLVLPSAIENVISSAAIAVPHDTVIEELESIASKKKVSMAMAIYLLGFGEYTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICN2</accession>
    <name>R7ICN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000149">
        <property type="protein sequence ID" value="CDE49649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49649">
        <property type="protein sequence ID" value="CDE49649"/>
        <property type="gene ID" value="BN770_02073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="281" mass="31122" checksum="390F203D6F476BE7" modified="2013-07-24" version="1">METGFKRNLLAELLDSVGRGVLLMALGSGWFVFLWGLNLPALLAGIALGTLLLLLRRLYRQTTLARRETALRCRIGGELLLEKMLLSEAKEAHFQAALLLEEKWPLRMQRITADGALCGQEKPSGGAETLLVQCVRMPPEGELSIGQLVEAHRAMQRQQANRVILCVLGKAPPRVIARAEQMPTPIRVIRRETLLALAGRLSPATDAQLVALGQRKRRTPQRGSLLSIMTQREKAPRYWGYGLFMLVLYILTGSAWYAMPGTVCLTLSVVCRSGQAEEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICR2</accession>
    <name>R7ICR2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thermostable monoacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_01620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="9firm-r7icr2">
        <property type="family name" value="CarbLipBact_2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48287">
        <property type="protein sequence ID" value="CDE48287"/>
        <property type="gene ID" value="BN770_01620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE48287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28398" checksum="1DDEF7834D3B88CF" modified="2013-07-24" version="1">MKTRPEADFSSPLCQPYEVRQGEHGVLLMHGFAGSAAHMRPLAEGLVQQGFGVRTINLPGHATTLEDMRRCSWQDWLNAAKEAFREMKEQYRFVSVTGLSMGGCLTLMIAEQSDPTAIAPISAPMGVLNRWFPLARFAAPFLPEISWQARKDDALAPDYDLGYTGFPTKSAVDLRRIIHEARNNLCAVTCPVLCVQSSGDQVITPDSADVILQGVRSKTKGVLRLENVPHVCTISREGAHIAQALGTFFRKAEESERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICX0</accession>
    <name>R7ICX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000138">
        <property type="protein sequence ID" value="CDE49158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49158">
        <property type="protein sequence ID" value="CDE49158"/>
        <property type="gene ID" value="BN770_01922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="51" mass="5399" checksum="D6178FD36A4F5FE6" modified="2013-07-24" version="1">MRVTGSSIVISWPVMSVRVTDSASADMLSSIASASSRAKKRVDFIGVSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICZ5</accession>
    <name>R7ICZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000144">
        <property type="protein sequence ID" value="CDE49510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49510">
        <property type="protein sequence ID" value="CDE49510"/>
        <property type="gene ID" value="BN770_02036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="187"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="324" mass="36328" checksum="439D3DCE14A50CDA" modified="2013-07-24" version="1">MDIQHQILEKMKAYDTIMLFRHSRVDGDCVGATKGMKALIQASFPDKKVLIVDDEHSDYLAFLGEDDAPVADDVYAQSLAIVLDVSVASRISNPKYALCKELVKLDHHINVEPYGDLMWVEEERSSACEMVADFYDKCRDELTLTKDAALYLYTGMVTDSGRFRFSCVSGDTMRLAAMLLDTGIDTEWLFANLYSVEYNSLKFKAYVYENMHRTENGVAYFSVSKDVQTQFGLSYEQASAAISYLEGIRGYLCWLAFIESPDGSTRVRLRSRFLTINQVAEKYHGGGHACASGATVYSTDEAAALIADADEAVREYKAAHENWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID18</accession>
    <name>R7ID18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49203">
        <property type="protein sequence ID" value="CDE49203"/>
        <property type="gene ID" value="BN770_01937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="213"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="511" mass="54450" checksum="E64BBEEE16B47BCE" modified="2013-07-24" version="1">MLARTLGYGLSGVSGFAVKVEVYAATGMPALEIIGLPDASVKESRDRVSAAIVNSGFTMPISRLTVNLAPADQRKEGPAFDLPIAISILMASGQLEGMDLTQTLMLGELSLDGSLHPVRGALSMVISASEQGIVDIILPEGNAEEVACIQGLQVYPASSLRQVVNHLKGREPIPVQQQRQYSDVVSAVKCAVDMAQVQGQVGARRALEVAASGGHNLLMVGTPGSGKTMLARCLPGILPPLTFSESLETTRIHSIAGRLAPGTGLMAERPFCAPHHSASVASMIGGGSNAKPGEVSLAHNGVLFLDELPEFSRNTLEALRQPLEDGVVSVTRIHNQAQYQSSFMMVASMNPCPCGCYGSKTKKCRCSAKDIRRYLDRISGPLLDRIDIQVEVDAVPVKEISEGGAAESSAEVGARVRKVRELQQARYAQDGIHCNAQLDAGLSKKYCPMTPEATALLHMAVERMGMSMRAYGRVVKVARTIADMDGADTIGTTHVAEAIQYRELDGKYWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID36</accession>
    <name>R7ID36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease (ExoA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49336">
        <property type="protein sequence ID" value="CDE49336"/>
        <property type="gene ID" value="BN770_01983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27051" checksum="742483C452C59ACF" modified="2013-07-24" version="1">MKLISWNINGFRSLMNRTLLDAFARLDADVYCLQETKLQAGQGELDLPGFTGIWNYADRPGYSGTAVLTLRTPVFSRFGLCEDETDTQGRVITADLGDFYLVNAYAPNVAADLSRLPERIAWNDALLRHLQALDAQKPVILCGDLNAAYNDADLAGKSQGMHVPGFTREERSGMAALLQSGFVDAYRHVHPDTAPGAFAYRKGIRAGGLDYFLVSERMVERIVDANAHPRIRGSDHYPMELVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID37</accession>
    <name>R7ID37_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein BN770_01944</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49223">
        <property type="protein sequence ID" value="CDE49223"/>
        <property type="gene ID" value="BN770_01944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="116" mass="13159" checksum="FC8C53CF49738D89" modified="2013-07-24" version="1">MKRYDAGIQGEQEAENALTRQGMTMRTRRYRAEDGEIDLVMQDGETIVFVEVKARPQSRAGQGMLAVTPAKQRRICHAAMHYLLENDCMDVPARFDVVEITRDGLIHVKNAFMASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID58</accession>
    <name>R7ID58_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type-2 restriction enzyme</fullName>
            <ecNumber evidence="1">3.1.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.21.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DpnII type II restriction endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.4" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49228">
        <property type="protein sequence ID" value="CDE49228"/>
        <property type="gene ID" value="BN770_01947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021191">
        <property type="entry name" value="Restrct_endonuc_II_DpnII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007637">
        <property type="entry name" value="Restrct_endonuc_II_DpnII-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04556">
        <property type="entry name" value="DpnII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016080">
        <property type="entry name" value="Restrict_endonuc_II_DpmII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="DpnII" evidence="2">
        <location>
            <begin position="4"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR016080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="282" mass="32865" checksum="FD254AF7BE0C01D1" modified="2013-07-24" version="1">MNRDFSQWLKTFRQSINGYTYYIDFAKVYGNVEKLKVEINILNSLICSKDIEHDFDNLIAKYPDCLKAIPILLAVRENEIYCQDKNGSVNYKFSQKVQSAEQYKYFMRETGLFDMLQKHIISNLYDYVTGVEVGLDSNGRKNRGGDQMENLVERYLQEAGVAYYKEMYLTEIERKWNMNLSAISAKGKSTKRWDFVVKTSNCVYVIETNFYTSGGSKLNETARSYKMIAEEAKTVEGFEFVWITDGGGWTSARRNLEETFDVMEHLYNIADMEQKIFTSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID71</accession>
    <name>R7ID71_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49739">
        <property type="protein sequence ID" value="CDE49739"/>
        <property type="gene ID" value="BN770_02113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="143" mass="15188" checksum="53B434D17553122F" modified="2013-07-24" version="1">MLGFLSAILAGAAMSVQGVMNTRLGEKVGTLETNAFVQLIGFLLALLIAVFFGKGNIRLLPQAPWYAWLGGVLAPVITLTVMWAIGSLTPTVAISAILLSQLTVAALIDVFGWLGAEKMPFSWEKWVGVALMVGGVILMKIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDM4</accession>
    <name>R7IDM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49919">
        <property type="protein sequence ID" value="CDE49919"/>
        <property type="gene ID" value="BN770_02187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="278"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="432" mass="47312" checksum="9E97F9F44870CAF4" modified="2013-07-24" version="1">MTIFIALATTFVQGGFNTALIQKKDVDGNDYLTILMFSEIVAAALYLVIFFTAPFISNIYHTSELSSLLRVMAIVLFPGAFNAVQVAYVTRDLRFKVLTISSFVSALLAAAVGIGLAVAGFGAWALVIQQLVNQTATCFVTYCIVRWIPKGRFSVQSLRRLLPFGAKVFASNFIVALFLDIRSLLIGQIYSSEALGFFNRGKQFPQAVMESVNGTIQTVLLPVYSQKQDSVSSVAKMVSKTVRISSLLLFPMMVGLAAVAEPLVSLLLTDKWLECVPYLQIFAIGYLFQAIQLAIIQAIKAIGDSGTPLKLEIIKKCVEVFFLIVTIRQGVLIFASSLLICSVISHLLNMFAAKRILNYTVKQQLIDILPATLFSAVMAACVKCVTQLLNGAFVSLVAGIATGVAVYLLLCMLFRVPEIKQLKNKLFKRKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDT0</accession>
    <name>R7IDT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49984">
        <property type="protein sequence ID" value="CDE49984"/>
        <property type="gene ID" value="BN770_02216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014998">
        <property type="entry name" value="DUF1848"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08902">
        <property type="entry name" value="DUF1848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35410" checksum="004DD5A5C5D32BFF" modified="2013-07-24" version="1">MILSVSRRTDIPAFYMPWFMNRLREGYVMVRNPMNYHQVSRVSLSPEVIDCMVFWTKNAMPLTPHLGEIALQYPFYIQYTLNPYGRDLEPGLPPLAQRLASACAIAEQFGSKHVVWRYDPIMLTEQYTADWHIEQFAAMADALKGSARDCVFSFVDLYDKVQANLRGLGVRICSDGEMDRIAAAFAAIARENGFRLRTCAEKVDLQRYGIAHGCCVDGDLIAELTGWTMAAKKDPNQRPECGCLESIDIGQYNTCRHGCRYCYATFNAKTVETLSARHDPASPFLIGQAEPGDKVTERKMKSLKKAPSGQISFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IDV2</accession>
    <name>R7IDV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase RecJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000144">
        <property type="protein sequence ID" value="CDE49508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49508">
        <property type="protein sequence ID" value="CDE49508"/>
        <property type="gene ID" value="BN770_02035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="205"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="313" mass="34674" checksum="1CDA4A87D53EC595" modified="2013-07-24" version="1">MFELIRDAIAAHQTIILHRHTNPDGDALGSQIGLKHLILANYPDKTVHMVGDGAGRYGFMEDSIMDEIPDSAYQGALAIVLDTSAKSLISDTRYTLAAQTARIDHHIFVEKIADIEATDDTFESCCGLVAQMAQECSWSLNPQAATALFTGMVTDSGRFRYDATNARTFRLASYLMEQPIDTNALYRNLYASDYAQLVVRAKFLLHVQFTEKNVAYVYTTMDGKAEYGVDDFTLSRGMVNSMADMRGVDIWVNFTESDKGVLCELRSSRFNINPIAVKYGGGGHMKASGATLKNREEAMAMLHDLDEMMGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE16</accession>
    <name>R7IE16_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-O-beta-D-mannosyl-D-glucose phosphorylase</fullName>
            <shortName evidence="4">MGP</shortName>
            <shortName evidence="4">Mannosylglucose phosphorylase</shortName>
            <ecNumber evidence="4">2.4.1.281</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man-Glc) to mannose 1-phosphate (Man1P) and glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = alpha-D-mannose 1-phosphate + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32531"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:64351"/>
            <dbReference type="EC" id="2.4.1.281"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.281" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000120">
        <property type="protein sequence ID" value="CDE48802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48802">
        <property type="protein sequence ID" value="CDE48802"/>
        <property type="gene ID" value="BN770_01821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00928">
        <property type="entry name" value="Man_Glc_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028583">
        <property type="entry name" value="Man_Glc_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE48802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="393" mass="44374" checksum="E21042CFFB9555A6" modified="2013-07-24" version="1">MQIRSFSSLMESYERLIARPNPANDHFYNGLYTRYRYPVLTREHIPPFWMYDADPASNPFMMQRLGVNATMNSGAIKLNGKYCLVVRVEGMDRKSFFAVAESDKPTEGFRFRDYPVVLPDTCAEETNVYDMRLTQHEDGWIYGVFCSESKDRTSSDLSAAVAAAGIVRTKDLQNWERLPNLKTLRSPQQRNVVLHPEFVDGQYAFYTRPMDDFIETGSGGGIGFGLCKDIEHPVIDEEKIISLRRYHTITESKNGAGATPIRTDKGWIHIAHGVRNTAAGLRYVLYAFMTALDDPSRVIAEPSGMLLGPMGHERVGDVSNVVFSNGAIADDDGKVYIYYASSDTRLHVAETDVDRLCDYLLHTPKDPLRSPDCVRQRCLLISHNLAFMGKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE25</accession>
    <name>R7IE25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_02047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49578">
        <property type="protein sequence ID" value="CDE49578"/>
        <property type="gene ID" value="BN770_02047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="3">
        <location>
            <begin position="343"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="410" mass="44374" checksum="CCC4AED1852970E9" modified="2013-07-24" version="1">MRYTREQACLAWLAQGMLGSRRLKKLLDEYGSAEAAYDAFQRDHGASLQNRISDYSLSLLRASASREKLHDMLVTMRKWNMGLVSMADDMYPESLRNIPEPPYMLFYQGDLRAAEGRCITVIGSRSATVAGIAATKSLCRDLSKQGVCIVSGLAVGIDAAAHEGCLDGGSPTIGVAASGLNVPYPSENVALKARILSQGGLLLSEYPPDMQSSKYVFAVRNRILAGLGHAVVLMEARIRSGSMLTVHHALDQGKDVFAYPGIPDAPMSEGAHQLLREGAVYFTSAKDILEDMDWQPAASIPKRQDTGQPRPAPRKRETQPAPAKALKAPPVMEQKAPPPEPPKAPEIPLPPMDDVQKRIYDALADGERSFDQLASQTGLDASKLMASLTMLQILGAVKALPGKSYCRATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE54</accession>
    <name>R7IE54_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">BN770_02180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49900">
        <property type="protein sequence ID" value="CDE49900"/>
        <property type="gene ID" value="BN770_02180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE49900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="236" mass="26946" checksum="94C76519E73DFCB0" modified="2013-07-24" version="1">MKKLEQLYEGKAKKVFATDDPNVVLVDYKDDATAFNGLKKGTIMGKGVINNRVTNFLMKMLEKNGIPTHYIEEISDRETLVKKVHIVPLEVIVRNIAAGSLSKRLGLPEGTKLKQTVLEYCYKDDELGDPMVNEYHIMAMGWVSKPVLDQIAAYALRINELLTAYLKEVNIELIDFKLEFGITNDGQLVLADEISPDTCRFWDTRTGEKLDKDRFRRDLGNVEDAYIEIRKRLMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE64</accession>
    <name>R7IE64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49613">
        <property type="protein sequence ID" value="CDE49613"/>
        <property type="gene ID" value="BN770_02050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE49613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="382" mass="42118" checksum="225E0680D9A35C5F" modified="2013-07-24" version="1">MNIDKKTCINMGIVVFLLYLAIHYWDGLVGLFNLFLAAAGTLINGAIIAYVLNILMRFYERHMAPNTKKKVWNAMRRPVCMALAFLTLVAVIVALIQIILPQLISCVQVLLSSLPGVLRQMYDKLMENPTIAALMADYNLVLPATEQEWREIIERAANLLFSGAGNVVNTAVSFTTSVIGSILSLLMSLIFTFNILIGKETLQRQSCNLLHRILGDTRMARAMHIISTLDDCFHNYIVGQCTEAVILGTLCTIGMMLLRLDYALMLGTFVGMMALIPIIGPYIGAAVGCIMLFSISPAKSLEFLIYLFLLQQVEGNLIYPHTVGSKLKLPGLWVLAAVLIGGGMMGISGMVLFVPLTAALYRLVGEWVRRDPRLVKSAVEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEC7</accession>
    <name>R7IEC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49985">
        <property type="protein sequence ID" value="CDE49985"/>
        <property type="gene ID" value="BN770_02217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="158"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="361" mass="39905" checksum="FAD2441D972B1582" modified="2013-07-24" version="1">MKVSDGMNYAPKGKAQPVVKPGEFIFSAAHLDHGHIYGMTNGLLEAGGTLKYVYDPDPKKVEAFVKAYPQVKVARSEEELLNDKETNMVCGAAITNERCALGLRAMQAGKDYFTDKAPFTTLEQLDSAKKMAAQTGKKYMVYYGERLHVEGAVLAGNLIEQGAIGKVIHVEGFGPHRLGAAGRPQWFFEKEKYGGILCDIGSHQIEQYLFYAGEEDGTVSRSRIANYAHPQYPELDDFGDCAINGANGTTFYFRVDWFTPDGLRTWGDGRTIIIGTKGYIEIRKYVDVGTERDGGNHVFLVNDQGEQYINATGLTGYPFFGDLILDSLNRTENAMTQAHAFKAAELCLIAQKQAEMVYQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEI1</accession>
    <name>R7IEI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein LpqB GerMN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50040">
        <property type="protein sequence ID" value="CDE50040"/>
        <property type="gene ID" value="BN770_02241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448206" evidence="1">
        <location>
            <begin position="22"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="73"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="330" mass="36521" checksum="CF9FB1FACE66E646" modified="2013-07-24" version="1">MKRLRLTLLLLMLMMMLTACAPSGNSMEALSVTAAPQEDEIPRADGDDAAATDTSALIWYRYGDEPMLVAEQRTVSRLPNEPYETALLRLLLEGPSLDAPALRGLFPAGTRVISTSRQGEMLFVTLSYQLMNGYSDEPSNWRSDTAWAQEVPLRRRLAMQAIAATVTENTTAQQVVILLEQRGETTDSMRLRQKYYTLNAADDALADPLRRDESLLLTASGTMRTILTCIQQRDIRRLYRYLAQSDPDTGEARMEYEAFASKWTEYPALTAFDFSGGSASGTRAVFTVSGTRLTDGVSQKFTGRSVHLMKTGGLWCISMSQLTAIVEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEI3</accession>
    <name>R7IEI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation stage III protein AG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49826">
        <property type="protein sequence ID" value="CDE49826"/>
        <property type="gene ID" value="BN770_02151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE49826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="113" mass="11909" checksum="90EB197AC0AA3162" modified="2013-07-24" version="1">MNMTRFRELLRRDGWLYAAIALCVVLALSVSAISGSSPDEETRIARVLSEIAGAGSVSVTIYTEDSQPCGAVVVASGAEDIAVRLRLQEAVTTLLGLDSSRVAVYPRKGGNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEK0</accession>
    <name>R7IEK0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stage V sporulation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_02165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000153">
        <property type="protein sequence ID" value="CDE49856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49856">
        <property type="protein sequence ID" value="CDE49856"/>
        <property type="gene ID" value="BN770_02165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE49856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="423" mass="44860" checksum="87DDC39A1DDB85FD" modified="2013-07-24" version="1">MPQTLKKQALTLTIANGFTRGLGFLFRLMTARLMGAEAIGVMELSASAAMLALTPATAGLPTAMSRMTARPNADQSAVLRAGLSLNRRIALVMMPLLFLLAPGMAWLLSDFRTLPAILISIPAVFLLGCCAVYSGWFYGRGDMLTPAQCECSEQVVRFVGSLVLLLIFTRSPLSIRAALPGFAGILAGICVWMMFRRRAPLPPGVPSADLRHELLALSAPTAVSRLCQTCLRMLTAVLLPLCLRQSGLTASAATAQFGLLSGMAMPLIMAPGVITSAMCMVAAPAVSRQESNRVRLKRTMRQLLLMAGLIGCLSSCVLFLFAQPISMLLYGEPALTGVLMALSPLSMLFAIQQVQFGLVTGLGVQRRAMTGTIVSSALTLVVMSALCPMPSVRIFGAVLAMLAGSLVRVIWNAAVLQSAKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IER7</accession>
    <name>R7IER7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylglycerophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BN770_01915</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="5"/>
    <dbReference type="EMBL" id="CBJB010000131">
        <property type="protein sequence ID" value="CDE49077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49077">
        <property type="protein sequence ID" value="CDE49077"/>
        <property type="gene ID" value="BN770_01915"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDE49077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="194" mass="21193" checksum="A6501B1FB306503F" modified="2013-07-24" version="1">MNLPNKLSLLRVALIPVMVALMLPQTLVCDLLAAAVFAVAALTDYFDGHIARSRHLITDFGKFIDPVADKLLNLSAMMMLVQRGTLPGWVVVLILARELAVDGLRMVAVGQGRVIAAGKLGKIKTASQMVMLLFVLITHQPALTAPAWDVVNATVLGAPWMRWISTALTLWVAAITLWSGIDYFVRNKDCIKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IES0</accession>
    <name>R7IES0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BN770_02202</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 8"/>
    <dbReference type="EMBL" id="CBJB010000156">
        <property type="protein sequence ID" value="CDE49941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49941">
        <property type="protein sequence ID" value="CDE49941"/>
        <property type="gene ID" value="BN770_02202"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="12">
        <location>
            <begin position="312"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE49941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="401" mass="44426" checksum="A31300A1442B1AEA" modified="2013-07-24" version="1">MRAYKIAVAGAGYVGMAMAVLLSQHHQVTVVDVVPEKISMINRRESPVRDDVMQQVLSHTPLQLSATLDAQAAYAGADFVVIAVPTNYDDVTQRFQTAAVEEVIGLVTQCNPDAAVVIKSTVPVGYTASVREKFHNRNILFSPEFLRESHAMEDSLYPSRIIVGTDMQDTRLTASARAFAALLQEGAEKPNVDTLLMGFSEAEAVKLFANTYLALRVAYFNELDTYAESKGLNTRKILDGVCLDPRIGSHYNNPSFGYGGYCLPKDTKQLLANYADVPQNMISAIVESNKTRKDFIADRVMALTTENHPVIGIYRLTMKRGSDNFRQSSIQGVMQRLKAKGASIVIYEPTLPDGETFSGSRVVNDLAQFKAMSRIIVANRYDKALDDVQDKVYTRDIFQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IES2</accession>
    <name>R7IES2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain-containing protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50125">
        <property type="protein sequence ID" value="CDE50125"/>
        <property type="gene ID" value="BN770_02290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="265" mass="29980" checksum="49A6AB9600A8D852" modified="2013-07-24" version="1">MKIGLSSAAYYGQLETDEAAAHIAELPLDTCEVFLETPSEYTTDFTFRMRYNMNNFPVTSVHPLSTQFEPQLFGRAARQSDDAFAMFANVCRAAESLGAAYYIFHGPFGVRGHLSPANIPFLEERFDQMRERAARHHLRVLWESVSWCSVATPEDVRILLKRIPDVEFVLDTKQVHQAGVDPLDMLRAMRGHVRHLHVLDWTADGKLCLPGRGVFDWQQFARVLREDGFDGAVILEPYAQLVESEQALLESICFLRGVFGAPAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IES3</accession>
    <name>R7IES3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Modification methylase HemK family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50289">
        <property type="protein sequence ID" value="CDE50289"/>
        <property type="gene ID" value="BN770_02350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010787">
        <property type="entry name" value="DUF1385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07136">
        <property type="entry name" value="DUF1385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="122" mass="13629" checksum="1B86DAA05A213AA2" modified="2013-07-24" version="1">MLISIVLFLFVGRDITNAALRMLVHLCLLPVVAGVSYEVLKGLAHSESKIAKILRWPGLQLQRLTTRQPDDGMLECAIVSMNVALYGLPEDAPRTEEGWAILTSYEQSEPDYVFPQKGEDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEX9</accession>
    <name>R7IEX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_02312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50170">
        <property type="protein sequence ID" value="CDE50170"/>
        <property type="gene ID" value="BN770_02312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009459">
        <property type="entry name" value="MucBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06458">
        <property type="entry name" value="MucBP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447895" evidence="5">
        <location>
            <begin position="33"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1315"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="724"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="938"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1267"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1349"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1368"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1452"/>
            <end position="1477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1477" mass="160707" checksum="F3F5204236380C38" modified="2013-07-24" version="1">MRKSGVKGLGRLLSVLMVAALLMTTAMVPALALDRWEDVVVSVIWTDSQGQQQTTQAFPVPDSAEHAYWATLDASALFSTVQVQVVSSDPAYTFYLKDYASEIMWTQDATALDPMYSYEVDYYCNSVYEGMFPLYLSSQGMPETPAQESVNVPVYYVTEDGQQLDFQYASCLTNATTQVYANSSVVPWDYLLVKPASGVVDVFVDSMGNASPSEVRFVYAVPEQPTEAPTEVPTEAPTEPPVIQAEVTVLYQLDDNGTILDTQYVMLNQGDNYVTANSAMTAGYQLVGEDTVHVWVDNGGTASVNPVVFHYATPQPVTSNIDVFYYHENGTLLDQQSQPLTEGVNYIYAASDRVGGYDLVSENPQTVTLRPDGTTDLASVSFFYADPQPTEVNVPVHYLNSEGEPVAMDDTLTLGEGTHLVTANPQGMADGYVPMPGTESTVEVNVSGGIATPSEVYFYYYIPTTEAPATEAPTDTPAPTDTPAPQTMPVAIHYFDMSGVEIADPVVKELLPGTYPMIPEREIPGYELDSTLTQFDLTVDANGTLYMDGEEIPADAVGFYYHPVQTPTDVPATEAPTDTPAPATDVPATDVPATEAPTDTPAPAQQFVTVTIRYYNTLGEEIADASVAELMPGTYHVTPAYDSIPGYELESSWTSFELTIYADGTIAINGDEATAEDLAFYYRPVQSAATDVPVTEAPTNTPIPTETPTTAPTEAPIPVGQPVNRYATINGNRVAFRSEASTSKSNTIIKRLANGSNVYVVNEMLNDKGERWSVVMVDGQSGYIKSEFLTIMTQAESDAYAASTGATPVPTATPIPTETPTAIPTEIPTEVPTATPTAAPQNATITIQYLDSYGSPVANAQSMTLAPGTYTLRPMPTNLRDGYELIPGSEQITLTVFQDGTLSMDAADIAFWYRQVATAAPTQTPTEAPTPTPTAVPYEGYAITTRETEMRTGIGTGNYVMATLQANVLVYVNSQLNTAGETWDIVTTLEGTSGYVPDANLRYVTDEKAQEYIQQWNQSRSTPTPSPTPYVTPTPEQLTGLAYAVGNNVPMRYMPGDFSAIEAYLMQGEVVYVSGQDYLGSMPWHRVQYNGQWGYVRYDMLRFMTQAEIEAYLNNLNATPAPTLVTTPQPYDPTNYSSYGYVTTTTSVNFRQQPSMNASRIRKLYNYAFCFVLGTTTGTDGETWYHIRYNDQEGYVNGKYFHWMTVEELEEFLQSIEYKQGIQNNTTGNATAKPTSGLIPEEDKTINDWKGSGATVSYVPWQGFSTPGPLTSPTTAPAQETATPTPSASPTPTLEPLPTAATTYPVTNESGNSGLVIFIAIAVVLLLGGGGFAFMQYQKKQREVAMKAAQRRAQAARNADRPVARQAGQPQQMRTGAYATPQQRPQTSNGVSPVQVRPATPVPQTQDMQNRPQVGYRTPIQPLTKPQETPSTAAPKSTTTMENPYARPVAKSAEEAPRHRRRTDQYRQDDDSAKPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF83</accession>
    <name>R7IF83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000166">
        <property type="protein sequence ID" value="CDE50240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50240">
        <property type="protein sequence ID" value="CDE50240"/>
        <property type="gene ID" value="BN770_02329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="124" mass="13712" checksum="82B2C5234C19DE3B" modified="2013-07-24" version="1">MLIYTSVKPYPMDVLPDGTLLVDPWDMVTDCYKAAGAMMGFCLGWVLERHFVGFDAKGAGKARVIRGVVGVALLLAVRKGMKAAGNLLLDAHWLGFAEMFGLMLFAIVLYPALFQWVERRKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFC2</accession>
    <name>R7IFC2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50295">
        <property type="protein sequence ID" value="CDE50295"/>
        <property type="gene ID" value="BN770_02353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436520" description="NMT1 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="40"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="335" mass="36001" checksum="0BA932692F1F98B4" modified="2013-07-24" version="1">MKTRLLCFLMVLALLPCLALAEDAPQKLVVAEPVHLIGYLPLYVAIHEGYFADEGLDVTVVQATGGAHVTAVVSGDAFAVIGGVDSNNFANQGNADPIVGIVNCVNRANVYLFARTGLAPVSDSDEDMADFLRGKIIIAGRYGGSPNVLTRYLVKRVGLDPDTDVTLLENADAATVTAMLQYGQGDIGNGGEPQISEGVTAGIFEEPFVAFPDLGDYAYSVIGVKRSTMEQQPETCLRFVRAMMKALKAVQDDHELAARVLELEFPTLTEAGRQAALNRAYADNLWSADGIISRQAVDTLMEVVISSGIFDGTYDVDALIDMRFVEQVMQESAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFU6</accession>
    <name>R7IFU6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CBJB010000167">
        <property type="protein sequence ID" value="CDE50306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50306">
        <property type="protein sequence ID" value="CDE50306"/>
        <property type="gene ID" value="BN770_02357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE50306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="491" mass="56269" checksum="24C08EE21BE7BDC2" modified="2013-07-24" version="1">MRKSGILMHISSLPGAGGIGSLGKEAYAFADFLEASGMKLWQVLPMGPTGYGESPYQSFSVHAGNPMLISTEKLAADGLLTLDPGEEFMPTQDERVEFDQVRENKEKLLRKAFHQSEKGLLPEIRQFLRDERWVSDFALFTAVKQHFGGVMWRQWPDEGIKMRRKESLLQYRMMLDEDVRYHVFCQFIFFRQWKEFKAYCNNKGIELFGDMPIYVAEDSADTWTQPEVFQLDKNRAPKRVAGVPPDYFSADGQMWGNPLYRWTYLFFRRYDWWVERMRGMSKLYDIVRVDHFIGFANYYSIPYGAPNARSGKWIVGPGKKLFRRLKKELPNLRVVAEDLGVQSDRVRELLKFVGYPGMKVATFGFGGDADGNQHFPGNWSENYVAYTGTHDNDTTAGWIATADETTLKAAKDYLHFDSTDDGVEAFIRCVLSSPCCMAVVPMQDVLHLGSEARMNLPGTIGGNWAWRMKPGAATEDVARHLREMNQEYQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IG11</accession>
    <name>R7IG11_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50396">
        <property type="protein sequence ID" value="CDE50396"/>
        <property type="gene ID" value="BN770_02362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE50396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="333" mass="37196" checksum="419906321738D20C" modified="2013-07-24" version="1">MKIYTIRDIARLSGVSVTTVSRVLNHRPDVNPQTREKVEQVMAECHFVGNANARSLKQADTETIALILRGRENPFLNSLAEAMLQYTHGLTPAFLTEFIDEKADEFQTAVQLWHEKRVKGFIFVGSRIDERAQVLEGMDLPMVFATVNADKTALPRAASVFIDDRRMGYEAMRVLLNAGHRKIAVFGGARVGDDSFALRYAGAMAAMQEAGVPFEDKRFVETRFSLKGAYDTTRAFFATQSDTTAVFCMSDTVAMGVIRALTDMGRHVPEDVGVIGFDGIEMSKFFVPRITTIEQPIDEIARESVRVLMDMLENGRPPRHIVVPAKVQMRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGE9</accession>
    <name>R7IGE9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmJ</name>
        <name evidence="7" type="ORF">BN770_02429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50536">
        <property type="protein sequence ID" value="CDE50536"/>
        <property type="gene ID" value="BN770_02429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="37" mass="4319" checksum="7F79A9E071592027" modified="2013-07-24" version="1">MKVRPSVKPICEKCKIIRRKGKVMVICENPKHKQKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGG6</accession>
    <name>R7IGG6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">BN770_02442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50556">
        <property type="protein sequence ID" value="CDE50556"/>
        <property type="gene ID" value="BN770_02442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE50556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="181" mass="20447" checksum="CF667475C587216C" modified="2013-07-24" version="1">MATRIKEKYLAEAVPALQQKFGYKNVMEIPKLDKIVINMGLGDCKDNAKAFEMAINELTTIAGQKPMVTKAKKSIANFKLREGQNIGAKVTLRGARMEEFMDKLVNIALPRVRDFRGVSDKAFDGRGNYALGIREQLLFPEIEYDKVEHIRGMEMIFVTTAKTDEECKELLRLLGMPFAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGL7</accession>
    <name>R7IGL7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_02104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49722">
        <property type="protein sequence ID" value="CDE49722"/>
        <property type="gene ID" value="BN770_02104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="196"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="296" mass="33913" checksum="7AA65B69B34E2F58" modified="2013-07-24" version="1">MTRKHPAHELEEDVLVRTSNMGQGRSDYEAFHTLSPAIHLREIHTHDFFELYIHLNGFPRLYVDNKIVTLQRGSLMIFPPFVMHGIISQDTIRNYERVVLFISSGMLHQLGQGLLPLEQRLLDCTRRTGYHYQLDEAALSLCTTCIDRVAQNTGDERPESRLADYAAMTEFLLQILRVTQEAPMLQSAQPSPDTIQRVMAYINEHYAQPLTLEEIADAFFISKSYLSHEFVRYTNTSVYEYIQFRRICGAKLLIASGVSLTDAAFQSGFNSYSSFLRTFRKTAGISPTDFQRNLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGM0</accession>
    <name>R7IGM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000184">
        <property type="protein sequence ID" value="CDE50949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50949">
        <property type="protein sequence ID" value="CDE50949"/>
        <property type="gene ID" value="BN770_00255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025374">
        <property type="entry name" value="DUF4364"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14277">
        <property type="entry name" value="DUF4364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="248" mass="27452" checksum="E1166A78A80A680D" modified="2013-07-24" version="1">MQRKIIPDAENRLLILYALKTVGAMTDQQLLIVMTDTDLMNYITLQLTIADLESEGKLRRQGDTSGGTLELTDAGRYLLNSFEMHIPVSRRGLIDSGAAQWRERFAAEQMAAVEIFDLPNGEKGLHLRIVDRRNVLLDITFALPTGKRINCLQQRWQQCMNQVYLLLLSTLGSGHTPEKKLPDGCSVLQVSDSEWLTTACDNPTQPTITLMASLPTEETAHECAAAFPTMSAVVRDAILALLDGAQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGU7</accession>
    <name>R7IGU7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_02132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49782">
        <property type="protein sequence ID" value="CDE49782"/>
        <property type="gene ID" value="BN770_02132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016793">
        <property type="term" value="F:triphosphoric monoester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="75"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE49782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="334" mass="38289" checksum="D5BEF002CF395F49" modified="2013-07-24" version="1">MTIRERLEQEEAQRLSPRAVCAKDTRGREKPIVPCPMRTDFQRDRDRIIHCKAFRRLKYKTQVFLAPEGDHYRTRLTHTLEVAQIARTLARCLRLNEDLTEAIALGHDLGHTPFGHIGEHALDRLIPEGFRHNEQSRRCVEALENDGNGLNLTWEVRDGILCHSGKQFPATLEGQCVRRADRIAYLNHDLDDALRAGVLQPFELPADCLKVLGQTHGERINTMICDIVACSADKPELTMSPLVQEAMDGLREFMFARVYRDQWRQAEEARCKHVVEALFSYYSEHPGEMPEEFVLIGYKEGTARAVCDFVSCMTDRYAIRTYQQLFVPSGFSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGZ7</accession>
    <name>R7IGZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000181">
        <property type="protein sequence ID" value="CDE50875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50875">
        <property type="protein sequence ID" value="CDE50875"/>
        <property type="gene ID" value="BN770_00232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="73"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="312" mass="33773" checksum="1C74DBB076E14075" modified="2013-07-24" version="1">MKKKKRRTTRRKATRRTIFQLLLTLLMAVLLFVRSDAPNGDDFLAPIPTKLPMATAAPVSSADLTVYFLDVGQADGAILVSDGHAMMIDGGKASASQFVYAYLTKTLGIEHLDAIIATHPHEDHIGGLPGALNACTVGTVYSPVTQWDTKVFSSLVKYTERQGISLTVPSIGDSFYLGSAQVTFLSDGQGFTDTNDMSLVVRVDCGSTSFLFTGDAEWNAEHALLANGEPLQATVLKVGHHGSETSTCYAFLREIMPQYAVISVGKGNTYGHPAESTLSRLRDADVVVFRTDEQGTIICRSDGRNVTFETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IH02</accession>
    <name>R7IH02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000181">
        <property type="protein sequence ID" value="CDE50880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50880">
        <property type="protein sequence ID" value="CDE50880"/>
        <property type="gene ID" value="BN770_00235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="377"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="528" mass="61473" checksum="0A0375D3C7D0EDFA" modified="2013-07-24" version="1">MKQLTCEMCGGTDLLKQDGVFVCQTCGCKYSVEEARKMMGEVSSTPVEVKNAAQLENLLNLAKSSFESQNYEQAESFCNQVIAMDDKNYEAWKLKGEAVNYRTTAVNDRILEAHNCIMTAFNLLSEEEKEIKKYDILASLKNCHESDVYFWLKQFEENRPTLASVTKIVDVFTDSRTKINFAFIELGLHDSMDEYMMSFDNFFISNCITVCDNSWSTTVAYNYYRDYMGKGIDPFGRSDQRWVIEDTDLYRPTKQIWDTFLVESTCLTVLLGYAEKWSNDDTSPELLKKIYNNIIHIHECVISSGSWKIVWGYTSFWAKCETLGWHEEYGLSDEAKNNHRQMINEYREKLKEIPQKIEARQKAEQEKERKEKITKYWEEHAEEKAQLDNEQEELAKKMDELNAQIAAIEEKHAAELDQLREERDRRLPCEAEVSQQRDVIRKLEAQRAKCGIFKGKEKKAIQARLDNEARPKLESLKKIADDEKTIHHQKVDAQIAAIKEDGKELREEVAKLKKRSDEITAELTKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHB2</accession>
    <name>R7IHB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
            <shortName evidence="4">HDH</shortName>
            <ecNumber evidence="4">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisD</name>
        <name evidence="11" type="ORF">BN770_02209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49977">
        <property type="protein sequence ID" value="CDE49977"/>
        <property type="gene ID" value="BN770_02209"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="433" mass="46380" checksum="0C484EC773B18726" modified="2013-07-24" version="1">MIPILRASDAGELKRRVMNRSQLQNEEVSRIVKEIVARVRQEGDAALFDYTAKFDHVTMTAETVLVTKDEIARAYAAASPEWLDAMREAARRITAFHEKQKQNTWLNFDPAISLGQKITPLKRVGVYVPGGTAAYPSSVLMNVLPAKVAGVKEIIMVTPPGRDGSVSYPLALVAADLAGVDKIYKVGGAQAVAALAFGTESIPRVDKITGPGNIFVANAKREVFGHVGIDMVAGPSEVLVIADDSANPRYVAADLLSQAEHDPLAAAILVTDSETLAAAVQAEIARQTALLPRRDVIEKSLTAYGTIVVAPTLPDCADIANQIAPEHMELSVADPYGLLPLIENAGAIFLGHYSPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSLICCSRAELERVSEQVMLLARQEGLDAHANAVAIRFGKEIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHH8</accession>
    <name>R7IHH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000160">
        <property type="protein sequence ID" value="CDE50057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50057">
        <property type="protein sequence ID" value="CDE50057"/>
        <property type="gene ID" value="BN770_02258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="86" mass="10439" checksum="DD84FF3B7175C64F" modified="2013-07-24" version="1">MHEPGKYKVHDVGLQGWLKYQNMQPLYWERDEHGVMLIVYEKTPVLMELVRMYWEKNKKYLPKDPPETWYDTLASIGRKPSQRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHR8</accession>
    <name>R7IHR8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like_bact domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000209">
        <property type="protein sequence ID" value="CDE51314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51314">
        <property type="protein sequence ID" value="CDE51314"/>
        <property type="gene ID" value="BN770_00376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022038">
        <property type="entry name" value="Ig-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07523">
        <property type="entry name" value="Big_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004436632" description="Ig-like_bact domain-containing protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="2">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="646" mass="70422" checksum="3825278F6967FE66" modified="2013-07-24" version="1">MKIRLKHLCLALVALMCLVLLSSCGSAPQPKQSVASMEDIGIKAQPKTAYILGDPFDVSAGVLNLFYDDGTIKELPFTAEGVTISAPDMETVGTKTVNVDYDGFKVSYMITIETQKYAVSFDLNYAGASAPAVQMVETGAYAARPSDPVREGYRFGGWYADANATTAFDFSAADANATTAFDFSAAAITGDVTVYAAWTAVYSVTFDLNDGASQATTVVVDAGTPIQEMMAPAAAREGYEFAKWHTDPEADTPYDFTQAVGADVVLYAHWAEIQAGATMVAVTFDYNGAGTLTARTESIVSGNSVEKPQDPDVEGRTFTGWFTAPEGGEAFDFTAAVTEDITLYAGWDVEYYLVRFHYIIDGKDTVMRTREIDPGAKAAAGAVPVVAGYKFTNTWYTDAEYTQVYDFKKPVHQDYNLYIKPMKEYRFEAEHTFIDENKAGVGSSDNFSGLKLIFKDNGTAEASNGFWVSGLYYNTAFVEFVIHSDAAINDAMLQLRLSSEWADMYIAPEDTNFNGKDYYSFAISSAPAQVDEAGNVLKDEKGYAISVADQARTFDYTPIAITGAITFSQSMVDKRPFSDYLMTTEFALQEGWNVVRLTVNNSHAPYDGTMEATAPMIDCMSIFTDATLTWIPVEENVADPSRVNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHS1</accession>
    <name>R7IHS1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein TM1801</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000180">
        <property type="protein sequence ID" value="CDE50853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50853">
        <property type="protein sequence ID" value="CDE50853"/>
        <property type="gene ID" value="BN770_00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="288" mass="32459" checksum="E198455232CA7F9E" modified="2013-07-24" version="1">MSVDFNRATGLLILEVVNSNPNGDPDRENDPRQRPNGLGEISPVSVKRKIRDLIEDHDGVFFQSLPEAYIRQADLYCILESRGRDRAAITKEMNDNPNFMDSTFVRKYWDARIFGNTFLEDGGNKEYIKTGAVQFGMGLSISPISIVRHTNTNKAGVEEGKKSGMAPLAYRVVEHGVYCMPFYVNPNYAAKSGCTAADIELLKRAIPYMLDLTRSNIRPDVRLRHAWYMEHKNKLGSCPDYLLIDALTPKRIGNAEEPSSSWKDYQDVADLPEELKQRLAGVQDLANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7II13</accession>
    <name>R7II13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacterial transferase hexapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000165">
        <property type="protein sequence ID" value="CDE50222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50222">
        <property type="protein sequence ID" value="CDE50222"/>
        <property type="gene ID" value="BN770_02325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="219" mass="23628" checksum="EB3179D7889A511A" modified="2013-07-24" version="1">MLTIEQLYDLNHTLAADYLRQFTYPWEALVGIKAEILRIGAALDPAEYTEVSEHVWVHKTATVAPTAYLGAPCIIGARTEVRHCAFIRGSALVGADCVVGNSVELKNVILFDHVQTPHYNYVGDSILGYCSHMGAGSITSNVKSDKTLVTVRGAGESMATGLKKMGAMLGDYVEVGCNSVLNPGTVIGRESQIYPLSCVRGEVPERSIWKTGGVVVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7II85</accession>
    <name>R7II85_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000211">
        <property type="protein sequence ID" value="CDE51320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51320">
        <property type="protein sequence ID" value="CDE51320"/>
        <property type="gene ID" value="BN770_00382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="104" mass="11845" checksum="296DB16ABE5ED61D" modified="2013-07-24" version="1">MTREQFLSQYTGEWSPSDGHWFGLDFGWRGQEYRFQTDSMYHPANTVLPDGREARFGVYKKEGSAYALIGEYATPQEALAQCRIQGMPLGDILEDESTELLGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIA8</accession>
    <name>R7IIA8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BN770_00325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000201">
        <property type="protein sequence ID" value="CDE51201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51201">
        <property type="protein sequence ID" value="CDE51201"/>
        <property type="gene ID" value="BN770_00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="5"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDE51201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="393" mass="42013" checksum="866ABBD80B3283DB" modified="2013-07-24" version="1">MATLLLVVIYLSFISLGVPDSLLGTAWPVLYRELGVPLASQSAVSILCSLATMTSSMNSARIISRLGTGKVTAFSTLLTAAALLGFSFSGSFWFMCLMAIPLGLGAGCVDSALNNYVSIHYNATVMSFLHCFYGVGVMVSPYIMSVVINSAVGWRGGYRTASLIQALIGSILLLALPLWKKAHGEESIQAEKKMKVLPISQTLRIPGALMTCLLFLTFCAIEVICGGWSATYMVEAKHMPANLAARATMYFYLGMALGRFLSGVAAKKLTPWQIIFISMGILGVSQTTLLVSGNNVLTMAALLMTGLGVGPLYPNFNYMTPLHFGKDVSQSVMGMQMTFASIGTIAAPALCGVLGQLLGMGIFPAYLMIFYVLTAVGIIALRRTLRQVGRLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIN0</accession>
    <name>R7IIN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51639">
        <property type="protein sequence ID" value="CDE51639"/>
        <property type="gene ID" value="BN770_00541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="338" mass="37701" checksum="7351066F9AB4B545" modified="2013-07-24" version="1">MSKQTVTHAHPSGSFWARNRKSGGYLLRKTVRRKGYQLIRFLLLFGLCFMIIQPLLDKLSVSFMAERDLYDSTVISIPRHLTTANYSLAASKILLNYGTTFLNTLIVSLAVSVLQIAACTLVGYGFARFEFPFKKFWFAAVIITVIIPPQTISSSLYLHFNFFDIFGIFKATTGSSLNLRGSPIPYALMSATCMGLKNGLYIYMIRQFFTGIPKSLEEAAYVDGCSIFKTFWRVILPDAVPILVSCFLFSFVWQWTDTFYSKLFLGNIKLLSLEASTVADRLNSYVSIQLGLSGGASMGYQQQMVSTATLMLVAPLLVLYLFAQRSFVESIAASGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIT0</accession>
    <name>R7IIT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000227">
        <property type="protein sequence ID" value="CDE51540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51540">
        <property type="protein sequence ID" value="CDE51540"/>
        <property type="gene ID" value="BN770_00486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="274" mass="30846" checksum="910010C79AFD52E9" modified="2013-07-24" version="1">MQTYRQMLTELAPDAVFARQEGVSYPTFQKCTYYSHTAHRDTPVNVLLPTDYDEQRTYPVLYILHGYWDTQDWMARDAVGLNVMLGNLWASGEAEEMIVVLPYIFCDQELRSCTGMNLRNSLCYDNFVNDLTADLMPFIQQNFAAATGREQTAITGFSMGGRESLFIALTHPELFAWVGAVAPAPGLTPIPGSADHPGQLQESELTFGDTKPELLLISASRADGVVTSAPSGYRQVLQLNGEELVWHQLTNTQHDHTSVKPHLYNFCRMIFRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIY6</accession>
    <name>R7IIY6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51233">
        <property type="protein sequence ID" value="CDE51233"/>
        <property type="gene ID" value="BN770_00338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="31"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="289" mass="31394" checksum="31AB6C6D286D5C7D" modified="2013-07-24" version="1">MPSRVYFTRNIAPENVLKLYEACGLELSGNVAVKLHSGEKGNQNFLSPEFWRPMIEHVHGTVVECNTAYPGSRNTTAAHWQTMRDHGWSDAFTVDIMDEEGPDLQLLIPNGKVIQKNYVGKHLTRYDSLLVLSHFKGHPMGGFGGALKQLSIGVASSYGKAYIHGAGDAKVGFGADHDSFLASMADAASSVAKRFAGKAVYINVMKNLSVDCDCCAVAENPCMADIGIMASLDPIAIDQACVDMVYAATDDPGQKHMLERIESRHGIYTIECAAGLGFGSREYERVDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIY9</accession>
    <name>R7IIY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted kinase related to galactokinase and mevalonate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000220">
        <property type="protein sequence ID" value="CDE51446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51446">
        <property type="protein sequence ID" value="CDE51446"/>
        <property type="gene ID" value="BN770_00446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="Fucokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fucokinase" evidence="6">
        <location>
            <begin position="108"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="750"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE51446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="980" mass="107393" checksum="D191E5F1A935047C" modified="2013-07-24" version="1">MGNSYSLFLRQSYLDAWEDYRRSLHRADFPVWDYIILTASNEAQANAYRQQIAIRRAKNLLPERTHYAVLPDPDGLRVGSGGATLNALRYVCMQEGTFAGKRILCIHSGGDSKRVPQYSACGKLFSPVPRELPNGRRSTLFDEFIIGMSGVPSRIRDGMLVLSGDVLLLFNPLQIDAPASGAAAISFKEDVETGKNHGVFQMDEQGNVGEFLHKQTVETLTSRGAVNAQGKVDIDTGAVLFSADLLADLYTLVDTPAKFAAFVNDRARLSFYGDFLYPLASRSTLEQFYREKPDGSFTEELHACRTAVWQVLRKYRMRLLRLAPASFIHFGTTHELRALMTDGVSAYSFLDWKKCVSGCCSSANYALNNAMVEEGCCIHDDCYLEDSHVMGSAIIGSGTVLSHVTISGKNIPANVVLHSLKLTDGRFVTRIYGVADNPKEGTFLGGSMAAFGNVWDGDDHSLWQAKIYPVCDSMAESVDAALNVYALAMGAGNYDAWASAERVSLCSSFNSADTAAILEWETHLRKAVKVERFLSVIRRGGTIEEAKKIFQDAAISAYQRRLIAEKAASADVFTRMRIFYCLGKVLGDSQEGEAYIKRAFEEIQRMVLAGAAAHGTGLCAHHQPVEEEAAVRLPLRVNWGGGWSDTPPYCNEKGGTVLNAAILLGGEYPVEVHVRRLPKPMVVLESADMGARGEFTAISDLQECHNPYDPFVLHKAALIACGVIPREGGELTDITAKIGGLYVSTQMHGVPKGSGLGTSSILAGACVKALFQYFGVAHTEDDLYEHAMCVEQIMSTGGGWQDQVGGMTPGLKLITAPAGIQQKLNVRHIALSEDTKAELNARFTLIYTGQRRLARNLLRDVVGRYISNAPDSLYALEEIQRIAVMMAFELERGHVDDFAKLLNRHWELSKTIDAGSTNTCIDQIFLAIDDLIDGRMICGAGGGGFLQVLLKRGVTREQLNARLHDTFQDCGVDVWDCTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIZ9</accession>
    <name>R7IIZ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription-repair-coupling factor</fullName>
            <shortName evidence="9">TRCF</shortName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mfd</name>
        <name evidence="13" type="ORF">BN770_00523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CBJB010000234">
        <property type="protein sequence ID" value="CDE51620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51620">
        <property type="protein sequence ID" value="CDE51620"/>
        <property type="gene ID" value="BN770_00523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="674"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="856"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDE51620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="1227" mass="137093" checksum="54FACEB32075AE2E" modified="2013-07-24" version="1">MNQALLSGIASKAYDKLLKAAESKQPIAVTGLPDTMAAYIASKLCADTGKKVLLISGNDLKAAHDAEDGQQLLETGVACLPGGEIDLTRGASSHESAWRRLEALARAQEGEVRLLCTSMDAALQRMGSADRFREETIRLAPGDRIDLNDLIRRLTAMGYERVSMVEGKGQCALRGGIIDVYPPACSQSLRIEFFDDEVDSIREFDCISQRSLDSVEKCTLTPATEVLLPPADAEKAARRMRDAIEQQGGDLTPASSTLFSDLPPLPEDDADAPDFFDKNITPKIREKQQTAARKAELERRRAQLMADADMLAEGLPFKRIRAWLTVLTDDTYTVLDWFEPEIVVLSDPNLLRKRAEERRAGFAEDLEGAMSRDEAVKEQETLLMDWDELLRHVQGYATVAVTEFLEGMAGVAVKDAADLGVQRVAGYSSQIRPLAEDCDGWLREGYRVAVLCGGVARGQRLAAALEEHDVAASFAEKIDKLPEECVQVLPGTLTHGFIWEEARLIVVSDTDVYGTGYRKAKKRQAAGEKIAAFTDLKPGDFVVHEEHGVGIYLGTAQMKNGGTRRDYLQIQYQGNDKLYVPIEALSRVQRYIGNPANPPKLNKLGGGDWQKQKAKVKEDLKKMAFDLVKLYARRSQETGFAFSADTPWQREFEDMFPYELTPDQEQSVKEITADMESPRNMDRLLCGDVGYGKTEVSLRAAFKALMDSKQVAILAPTTILAQQHYNTVLKRFKGFPVKVDVLSRFRTAKETKDVLRRVKEGEIDILVGTHRILGKDVQFKNLGLLIVDEEQRFGVQHKEIIKNMKHQVDVLTLSATPIPRTLHMSMVGIRDMSVLETPPEERLPVQTRVIDYNDGVIRDAILREVSRGGQVYFLYNSVQTIGAFYERLKQLVPEARIGVAHGQMREHGLEDVMMDFYGGSYDVLLCTTIIESGLDVPTANTLIVFDADRFGLSQLYQLRGRVGRSNRQAYAYFTIRPERSLSETAEKRLEAIREFTEFGAGFRIAMRDLEIRGAGNILGPEQHGHLATVGYDMYCKLMEETLQEARAEQEGLPPAKPHLETRVDIKVDAYLPDDYVHDDRQRMEMYKRIASLTTQADREDITDELLDRFGEVPPVVETLLDVAQVRVLANQLGVSLVTYKRGGFLVMKLNAEYMPDQAAFIPAMAMTDKRLMPSTTAPDVLLLVDPTLGEYAMLSEAVKVLGKLNENIETMLKKQKKDAKPTVQNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ39</accession>
    <name>R7IJ39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51303">
        <property type="protein sequence ID" value="CDE51303"/>
        <property type="gene ID" value="BN770_00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="85" mass="9330" checksum="6E93749368FC75AE" modified="2013-07-24" version="1">MFVIVSNVVTVFKYLILTFLPLTFKGLWAVDFGWPGIEAEISGQPFTWNIFGYAVKEGGAVMGGLGYFIACMIAMVISEAINFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJF8</accession>
    <name>R7IJF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000250">
        <property type="protein sequence ID" value="CDE51909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51909">
        <property type="protein sequence ID" value="CDE51909"/>
        <property type="gene ID" value="BN770_00689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="75" mass="8334" checksum="6E44A5E0B43CDB1F" modified="2013-07-24" version="1">MSKFVPRPKLSKKARKELDAQKRTTWAFSPVTKKVESKKIYNRKKAAHVWKDDSSMSGFCCTGDGTAANAARGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJL4</accession>
    <name>R7IJL4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="11" type="ORF">BN770_00468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="CBJB010000225">
        <property type="protein sequence ID" value="CDE51513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51513">
        <property type="protein sequence ID" value="CDE51513"/>
        <property type="gene ID" value="BN770_00468"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="173" mass="19329" checksum="AB0E62038AB0C766" modified="2013-07-24" version="1">MLNRHVYIIGMPGSGKSSLGRRVASNLGLPFIDTDQRIEQSVGCSTSDIFAHYGEQAFRNAETNMLIELSREQGSIVSTGGGLVLRDVNREIMRNTGVIVLLDRPLEEIMGDIKLNRRPLLAQKGLGEVERLYHERIELYRKAADATLDNSHGYQAGMYGLQKLITTMFNIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJR1</accession>
    <name>R7IJR1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000255">
        <property type="protein sequence ID" value="CDE52019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE52019">
        <property type="protein sequence ID" value="CDE52019"/>
        <property type="gene ID" value="BN770_00750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE52019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="344" mass="37425" checksum="07DD289681EFFFC8" modified="2013-07-24" version="1">MAKVVTFGEIMLRLKSPAYERLFQSPSLEATFGGGEANVSVSLANYGMETAFVTVLPTNDVGNACIRELRGFGVDTTKIVRKDGRMGIYYLETGAVQRPSKVIYDRAGSAIAEAKPGDIDWDKAFEGATWFHLTGITPAISQGAADLSLEAVKAAKAKGIHVSCDLNYRKNLWKYGKDAKEVMTELVKYVDTVIANEEDFQKSLGLKAESQGDVEDGALNIENYKAIASLAMQTYPNIKRVAITLRESKSANHNDWSACLYNGKDFFLSRKYAITDIVDRVGGGDSFGGGLIYGLNTYADEKTALEFAVAASCLKHTILGDYNRVSVSEVESLMKGSGTGRVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJU2</accession>
    <name>R7IJU2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51583">
        <property type="protein sequence ID" value="CDE51583"/>
        <property type="gene ID" value="BN770_00500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE51583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="259" mass="29334" checksum="D00CE0FE4196E955" modified="2013-07-24" version="1">MENQEAFMLETQHVSKHYGKLEVLKDINLQVKKGEVICLIGPSGAGKSTYLRSLNQLETITGGKIFIKGHLLLHREHDHTVERIDKKTQQQLLLEMGMCFQRFNLFPHKTVLDNVMMSPIIVKHEDKEQVRQEALTLLDRVGLKSKADEYPNRLSGGQQQRVAIARALAMKPEIMLFDEPTSALDPELVGEVLNVMKDLASEGMTMLCVTHEMGFAKEVCNRVLFMADGYIIEEGTPTQVFEDPQNQRTKAFLRSVLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJV5</accession>
    <name>R7IJV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000231">
        <property type="protein sequence ID" value="CDE51598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51598">
        <property type="protein sequence ID" value="CDE51598"/>
        <property type="gene ID" value="BN770_00513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024499">
        <property type="entry name" value="Mbeg1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11187">
        <property type="entry name" value="DUF2974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="371" mass="40919" checksum="D66191AE93C829EC" modified="2013-07-24" version="1">MSYLPDYITWRGDLPFAADPANDLDTLVMAALSYIDLPAETQVFAQCANSVPPDDPDDHFRGECRRLLQQIAKSSRFGALTVRDAVSVLNDEIQFAAMTVDLPDETHIIAFRGTDGSLTGWREDFAMSFESPVPAQAAAQKYLEHHLMQDAGDVIVTGHSKGGNLAVYAAAHTKADLQGRIRRVVSFDGPGVDDETAASDGYAAVASRIIAYVPQFAVVGLLMAAHPVHRVVMSDNNGIMQHDPFSWEVRGKDFCYAEDLDKGSVLVNQTVHQWLAQCTREQRRKFVDAIFDLLASTQRINWKEMRKDVHAGVTAIRGVREQIDIETARMIANLLGRLAVIGAGNALEMLRQKTPFQQESAQKEQGGLEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJY6</accession>
    <name>R7IJY6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BN770_00707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000251">
        <property type="protein sequence ID" value="CDE51940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51940">
        <property type="protein sequence ID" value="CDE51940"/>
        <property type="gene ID" value="BN770_00707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="184"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="245"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE51940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="496" mass="54902" checksum="25A33DBC99FEDE9E" modified="2013-07-24" version="1">MTDRPKARRIRRKKDVSPAAPKPHGLPSTLSRIRLSLSFRIAAHFSFQLVRTFLPALLILTLAFAGGTLYLAERDISRLQCAPLSADGTITLSVLDDAEVTLLPEARTDGIIVGQSAYRLLDPEAIFTEGRYIVQAQHISGQSLLISLSLSRPLALYCGAAAALVITDLFRMFYFVLHRKRLQKSVLAPIRDITDMAATLSANNLSNRINIAGTKNELKDLATVINSMLDRIETSYNSQKQFVSDASHELRTPIAVIQGYASMLSRWGKSDPDVLNEGINAIAQETESMKELVESLLFLARHDKKTLMMEMVRFDAYDVAAEVQREAAMVTPEDTFALDPADHVQIEADRGMLKQVMRILCDNAVKYSPKGSTITLGVQKTESGCTLSMSDHGPGIPKEELSRIFERFYRCDSARKTESSGHGLGLSIARIIVMGHSGQLRVRSKVGAGTTFYVDLPLTQDKVRHGGEVNLPPEKKHRYRLRSKKDKSGYAEAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKB7</accession>
    <name>R7IKB7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">6-phosphofructokinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_00588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000240">
        <property type="protein sequence ID" value="CDE51728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51728">
        <property type="protein sequence ID" value="CDE51728"/>
        <property type="gene ID" value="BN770_00588"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="4"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="350" mass="38168" checksum="AD8398E6F5B74A2D" modified="2013-07-24" version="1">MMRKIGVLTSGGDAPGMNAAVMSIARSAAAYGMPLIGIKHGYNGLLRKSTSIKDDLQELYLDTVLDIADQPGTYLRTARCEEFKDPKWREIAVQTLKAMEIDGLVVIGGDGSFQGAMRLCELGIPCIGIPGTIDNDLAYTEMTLGYETAVQVCTEAIRAIRATSRSHDRPHVVECMGRHCGDIALKAACATGSEIVVVPEVPWSVEEVASRLNKQIAKGNYRSTIVLAEGCWESMAPFDMYGFLTSHGKQCFEGEPMSAMRFASIMKRMCGMVEARSTVVGYTQRGALPVAKDSAFAFEAGNLAVRLLRDGISNQVIGVRQGKVFNMPIVDALKVEKHFRRDLYDLVNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7IKX1</accession>
    <name>R7IKX1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000204">
        <property type="protein sequence ID" value="CDE51237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51237">
        <property type="protein sequence ID" value="CDE51237"/>
        <property type="gene ID" value="BN770_00342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="102" mass="11613" checksum="76318CFB7C6267E9" modified="2013-07-24" version="1">MARENNKICRVFKALAEPKRYRIVTMLANGKMSASEILKHFNVTQPTLSHDMRLLIDAELVNNQRIGKSVMYELNPEMLQNMIDVLTAIQHPETADSADEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IL13</accession>
    <name>R7IL13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000208">
        <property type="protein sequence ID" value="CDE51297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51297">
        <property type="protein sequence ID" value="CDE51297"/>
        <property type="gene ID" value="BN770_00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="99" mass="11203" checksum="0DB45F2FB2680D1E" modified="2013-07-24" version="1">MFPCDVEITDFRLHTASGAPVLTLSFCADGKAQTLRFLSISDVTLRFPAIPMQICGFEIRDHRADGWDADQRYEISDFEDGALHFFCREIETENGEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7ILH8</accession>
    <name>R7ILH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoVT/AbrB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000224">
        <property type="protein sequence ID" value="CDE51482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51482">
        <property type="protein sequence ID" value="CDE51482"/>
        <property type="gene ID" value="BN770_00052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE51482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="76" mass="8580" checksum="6134AFC60156B955" modified="2013-07-24" version="1">MMTAKLFENGRSQAVRLPKECRFSGDEVSVSKVGDAVILLPKNNRWSGFLTSLDMFTADFMPNGREQPDVQERESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I307</accession>
    <name>R7I307_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46249">
        <property type="protein sequence ID" value="CDE46249"/>
        <property type="gene ID" value="BN770_00802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="154" mass="17689" checksum="45C9B5D1ACF6F663" modified="2013-07-24" version="1">MIRRAVDADIPALDRLLFQVHQVHHEARPDLFKAGAKKYTDAQLSAILADDKTPVFVAERGGAVVGYAFCIHKQFVNDNNMTDIKTLYIDDLCVDERARGRHIGTRLYEYVLDFARQQGYYNVTLNVWADNVNARKFYEKIGLRVQKIGMEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3K0</accession>
    <name>R7I3K0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="12">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glycogen branching enzyme</fullName>
            <shortName evidence="12">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgB</name>
        <name evidence="16" type="ORF">BN770_00780</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="12"/>
    <dbReference type="EMBL" id="CBJB010000004">
        <property type="protein sequence ID" value="CDE46205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46205">
        <property type="protein sequence ID" value="CDE46205"/>
        <property type="gene ID" value="BN770_00780"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9 12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="15">
        <location>
            <begin position="168"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="663"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12 13">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDE46205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="693" mass="80562" checksum="9491F19D48C8C2DB" modified="2013-07-24" version="1">MRYNGPTAAVRDQFHQGTNRRAYEMLGAHPVTQDGQEMWHFAVWAPNARAVSLIGEFNQWDRKKTPMQKVYDGTWEVRLPAKTFDVKSDPKRYDYPDAAKKLTTYKYCIQAQDGTWQDKADPYGFAMQMRPDTASRIYDLSGYRWGDADWMEARKSYDPYHSPVNIYEMHLGSWRRHKDGTFLTYTEIAEQLVPYLKEMGYTHVEFMPVMEHPLDMSWGYQVSGYYAATARFGEPKELMALIDALHQAGIGVLLDWVPAHFPRDAMGLRRFDGTPCYEHPDPRRGDMPQWGTHMFDYARGEVNSFMLSNACFWLEWYHADGLRVDAVTSMLMYDFCREPGQWLPNKYGGHENLDAIAFLRRMNETVYRDFPGVMMVAEESSAYPMVTRPIYLGGLGFGFKWNMGWMNDMLAYIKLDPVYRKYHHDKLTFSLMYAFSENYILPFSHDEVVHGKHSMLDKQPGDLWKKFAGLRALYGYTMAHPGKKLLFMGGEFGHFIEWKYDDQLDWFLLLYENHPQVQQCCKRLNEIYRTTPALYQIDDSWDGFQWIQANDSDNSIVAFLRTDKRGNSLLCVTNFTPVFHPQYRIGLPQMGTLTECFNTDRKEYGGSNQYNNWAIRTEEEQLKDFQYSCDICVPPLATVYFTYQRDPLPEKAKKVRVIPEIADVPPKKASQTAKKPQPLPEKSAGKANSISIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I3L4</accession>
    <name>R7I3L4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidases related to nicotinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000017">
        <property type="protein sequence ID" value="CDE46494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46494">
        <property type="protein sequence ID" value="CDE46494"/>
        <property type="gene ID" value="BN770_00903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="180" mass="19996" checksum="C4AAEE7256342F5F" modified="2013-07-24" version="1">METGKRCLIVVDYQKDFVDGSLGFEKAVTLDHGIAEKIRLYHSRGDDVMFTLDTHNDDYPTTQEGKNLPVPHCIAGTPGHRLFGETAACRQKQDMVFFKPSFGSLELTRYLHTHPYQEIELVGVVTNICVISNAVLCKAALPEARVSVDASLCASNDEALHEKALDVMRGLQINVTNFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I426</accession>
    <name>R7I426_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BN770_00788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46226">
        <property type="protein sequence ID" value="CDE46226"/>
        <property type="gene ID" value="BN770_00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GD_AH_C" evidence="3">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE46226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="126" mass="13204" checksum="CE6B16FB759CA485" modified="2013-07-24" version="1">MRDVLAYGERVHTLGLNLLSAPGNDLVAATALASAGAQIVLFSTGRGTPFACPVPTLKIATNTPLATKKHGWIDFNAGQLLTDGKTLPELSQALMEDVLATASGRLVCSERNGFHDLAIFKTGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>R7I460</accession>
    <name>R7I460_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin V acylase-like amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_00986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000022">
        <property type="protein sequence ID" value="CDE46674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46674">
        <property type="protein sequence ID" value="CDE46674"/>
        <property type="gene ID" value="BN770_00986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="CBAH" evidence="4">
        <location>
            <begin position="100"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE46674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="371" mass="41705" checksum="4E3185D3B969182D" modified="2013-07-24" version="1">MKTKHHPLRTILLSLLILLLLVIVVFVGFYFTRLQTIQSIEQITDYDDGYNLYRMNVQYDYSLDRVIAYGITDNQTMLDAILKEALPLLPVSMKVPNYGCTAFTLTDTDGSVHMGRNYDFKRDTSAMLVYCAPKDGYRSVAFAALDNVGANIPDESLKKKLATLTAPFICLDGMNEKGVSIAVLTLDSEPVHQNTGKPTIATTLAIRLVLDRAATTEEAVQLLSSYDMFASSGRDYHFYITDASGDGRVVEYDCEKETRPLVATPMEAITNFYGLYRDKVLPNQRNGIYGHGRERYDAVMKVLEEQAEGYTNDTVWDALKASSQEPNPVDITSNTQWSIAYNNTGLTAEIVIRRHWDEIISYSMSQNDVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4I3</accession>
    <name>R7I4I3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46759">
        <property type="protein sequence ID" value="CDE46759"/>
        <property type="gene ID" value="BN770_00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447966" evidence="1">
        <location>
            <begin position="24"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="296" mass="33549" checksum="5EA863C086D57958" modified="2013-07-24" version="1">MKRILTFLLAAALLLTSLSCALADGTASSSDWMTKLTNKTLIQVVEKEIGKGWTLYQPNPREEDTKMSSNSFLKNVKLYPVVARKDDAMQLIILKKVNGKWKVDVCNDKALTRPELTIRNFSMDENVSSSDTKYTVYFDYLDAEGKVYVLSLTLYTEFESMFDDLHYLDGGVWESPSVSIEFINDRGFELYSYYSGGYTSTYHVYMYGKANFGVDEFQFADVPLQFSDLLTSAVCNAPEEGAPLYIAPDANATPVAQVHYRDEVQVIQQNPAGDWTIVCYQGNYLFIQTEYVNFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>R7I4W0</accession>
    <name>R7I4W0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription regulators</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000018">
        <property type="protein sequence ID" value="CDE46531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46531">
        <property type="protein sequence ID" value="CDE46531"/>
        <property type="gene ID" value="BN770_00925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="151" mass="17770" checksum="17F5021A3C477E0B" modified="2013-07-24" version="1">MRVDKSVIVLFRQMNLFLNRKLLDEKLTSSDVLYLALLYEQDGRTQDEMAEAYTVDRAATTRSLQGLEKKGLVRREVDTFDRRIRRVYLTEKAMQYRTAIRRMADDLANALFEGMSEEEVKAFMEQVEAMGQRARRLNQRQERLKAQGIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I513</accession>
    <name>R7I513_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46969">
        <property type="protein sequence ID" value="CDE46969"/>
        <property type="gene ID" value="BN770_01093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="688" mass="75858" checksum="CBE91E691D3984A0" modified="2013-07-24" version="1">MAILKMLDYASITDKLPITEKNEQYLRKIIDLCKQKNITLILMAAPFEATEEAAMRLNTVAEIAKEEGVPFLNYVKEWDSLGMDANTDFYDGGHFNNQGIVKFSRIVGQYLSQNYSLRDCRKIEGFIWNASQTTADKNKAEFILSNQFSGDGVSEYYDTKIKLYENRYSSWTILTQIGLPLPDTDEGQVVMACFDEQNGENYRGLLIRGEGNALQVILGNNRTFMLPLLHGDSATLAITKDNERYSIYLNGEKLYENEQLPCDAYSGTLLLGCEELTPGGEKFRFSPTRVLNLEVYDSVLTESEILAWQPEDLPEAPKPLGVGVKDAAEAYILPEQFVGGDETYRQASYLDTQTQLFASTATRFTLLTSVTPSENPGNGVFLSCFDENAKNYRGLLIRQLDNAQINIVFGQNVGVTVPGEFDREMHIAIVKDGASYRIYADGLLVAEAESPADSYDGTLLIGAQRDADGNIFRISQTQVNHLSLYAGVMTEADIAAYDFADAPLPPELVAESAAYTMPGAFVGNGSDRALDTGVKLYDVATKDWTLDTVIDVRKGVNNGVYMSCFSEETGHYRGFMLRQDNADTLTAYVGNSVGVTVDLPQGTSLMHLVVVKSGSQYTIWQDGQLVQRVESACDNYDATLLLGAQRDADGNLFRFSNAGIRTLNITDGALSDTDAAALSAPVKDNSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I534</accession>
    <name>R7I534_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000030">
        <property type="protein sequence ID" value="CDE46994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46994">
        <property type="protein sequence ID" value="CDE46994"/>
        <property type="gene ID" value="BN770_01095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="148"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE46994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="583" mass="64779" checksum="7E09198667AF11F3" modified="2013-07-24" version="1">MSRKKNLLDYLALTLFIMCMGLALSASLEYVTRATEREYLGQGIWVLSMAGLSLLALLLGRISRKCGQKMQPLPKNIVMIVFGAVLVGVGVYLRLWVIWNIPVEPDSDFETYYRMANHLLNDTLMSAEGAVDRRYIALYPHTIGFPMLILWPTFAIFGASVRNALYANLVCSVISILLAGHIARRIAGRTGALVAVALMSLWPSHILFSNMVATEPSFTMLILLAADMMTSILDRRKGSLYDVAPSRMLGVMALLGIVLALAGAIRPMAVILLAAYCVAQLCVTGDPMNEIRVEGARYATSQPIVCIVLVMVCYLVTGSVINRAISDIIGEQPASGLYASGYNLMVGLNTQSNGLWNETDSEFFAQAYDTAKSATGAHQACMEVAAQRIQSEPENVLNLMVYKFRDLWRTDDFGIDWNLLWTEQQGTLTPELRSLLESIRPIGRVMYMAVLLFAALGAMEAWRRRLAPNTMILICMLFFLGTALSHMLLETQVRYHYNMIPFLILLAAWTVRSWSKTAAEKEDVRVIYVDRPENAEEKKDNIHFDMAKAIAEGHIHVSVTENVARTEEASKMEDSAKSSVENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7I5L5</accession>
    <name>R7I5L5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000029">
        <property type="protein sequence ID" value="CDE46940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46940">
        <property type="protein sequence ID" value="CDE46940"/>
        <property type="gene ID" value="BN770_01084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="363" mass="40532" checksum="76C62D93F9026483" modified="2013-07-24" version="1">MKKIMLVFGTRPEGIKMCPLVNELKRRPQVQTVVCVTGQHKQMLQQVLDAFSVVPDYDLAIMQPNQTLFDVTTAILTRIQAVLNQEKPDLTLVHGDTSTAFVTALACFYLHIPVGHVEAGLRTYNLESPFPEEFNRQAVSLICRYHFAPTEKAKQNLLREGKDESSIFVTGNTSIDALKTTVRADYTHPELTWAQGSRLILITAHRRENLGEAMHHMFRAIRRVLTEHPDVKALYPIHLNPVVRQEAAEELSGLERLHIIEPLDVLDFHNIMAHSTLILTDSGGIQEEAPGLGKPVLVMRDTTERPEGVAAGTLKLVGTSEETIYREFTRLLDDPAAYAAMAHASNPYGDGHACERIADILCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6A4</accession>
    <name>R7I6A4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FeoA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000045">
        <property type="protein sequence ID" value="CDE47389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47389">
        <property type="protein sequence ID" value="CDE47389"/>
        <property type="gene ID" value="BN770_01234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="90" mass="9577" checksum="FA33354EB4E85265" modified="2013-07-24" version="1">MTIAELAPGQSGVIAAYRGADAEERVIAAYRGADGEERHLLDMGLTPGVRVRLIGTALLGDPLILLVRGSRVSIRRRLARQIILSGGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6E6</accession>
    <name>R7I6E6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="8" type="ORF">BN770_01024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46798">
        <property type="protein sequence ID" value="CDE46798"/>
        <property type="gene ID" value="BN770_01024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="368"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE46798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="590" mass="66101" checksum="257464C6D8066E88" modified="2013-07-24" version="1">MKQQVHGNVAGVRDTLIEALGQLYDYEVDEDTFLPRELMQVLARFTGVLNREIAVYITRDGEVVDVSIGTDRDVELRDYRLRRNTQRLSCVRCIHTHPNGDGRLSDVDLSALRSFRYDAMVAIGCLKGEPTFVQSAFLVEKQNLLMDEPVRWYKTPDNDWMRQITESDRIVGWEADEKGTHAKERAVLMGIESMESLDELARLADTAGAEVVGQFLQKKDKPDTALFIGRGRADELCRQCQALEADLCIFDEELTGIQARNLEEILRVKVVDRTTLILDIFAQRASSAEGKLQVELAQLQYQSSRLIGQGLVLSRLAGGIGTRGPGESKLEMNRRHIRERMTELRRRLDAVEKQRELRRKSREKNEIPVVALVGYTNAGKSTLLNQMTGSDVYVQDQLFATLDAVSRRIETAEHTPFLLVDTVGFIRKLPHALVSAFRSTLEEAVLADVLVIVNDGASEEITQQHDTVLQVLSDLGATEQPRIEVINKCDLYTDEAGAPMLIPGAVRLSAKTGEGIAELHARIAEQLQKTYAPVTFVLPFDRFGLVGQIRPLGRVVNEEYTDTGLELTVVLANADRDRLVSKYGKEILKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6H3</accession>
    <name>R7I6H3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNHCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000026">
        <property type="protein sequence ID" value="CDE46838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46838">
        <property type="protein sequence ID" value="CDE46838"/>
        <property type="gene ID" value="BN770_01046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024439">
        <property type="entry name" value="RNHCP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12647">
        <property type="entry name" value="RNHCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNHCP" evidence="1">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE46838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="140" mass="15615" checksum="A0EA0AB93A2C2574" modified="2013-07-24" version="1">MNRENKRKLYDKHYYKTHPCDEAFTCRHCGRLVVPEGAGSDHRNHCPYCLCSVHLDNAPGDREADCGALMEPIGVWVHKNGEWALLHRCRMCGTIHANRVAADDNPLLLMSLASKPLACPPFPLDKLEEMAALCGVSMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Y0</accession>
    <name>R7I6Y0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000005">
        <property type="protein sequence ID" value="CDE46262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46262">
        <property type="protein sequence ID" value="CDE46262"/>
        <property type="gene ID" value="BN770_00811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE46262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="517" mass="59141" checksum="ACC77C4179A15336" modified="2013-07-24" version="1">MAKKTKTQPKARKTITSNNLADLSKLVKELAQDDENPENQQKPSALDKKIIYNEFQNSTYTLVSPMAYLIGIDKENFGEENARPFLLKSYEELDAHKEARIIRNLCRIRTAMERNYPAIVNEFRMSFRNIGSVPNLIPSEAVAQLEQDGVRIYKAKPDIDEYIISINCEISNRINQVARFFPEWVKWDYVKPIFLMPNGTKKEGVKKAGEYYKSDNRRYPFHCWINWDAVSTSPESKGNILYNDEKFVTILYERHEDRFENLSLVRDAGNSTMRNLGRLLGQCKKCLIAVDCENSDAVKLAAALSSLPTEQLGKISKVILFDSEYTTPQWKTLVDRTLSTAVDEKANLELEHIKVERLNQNKSQCDMALAVRTSREVYTSGVDAVILVSSDSDYWAMIRQLDSVRFLVMLEKGKTGMAIMDTLARHEIPFCFIDDFCTAASYNIKTSTLINAIQEQINQQLAGESAKPFNVREMMETALQNSWIMMTDKEKEAFYKRYLLCMKLNVSQDGAVSITLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Z1</accession>
    <name>R7I6Z1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000046">
        <property type="protein sequence ID" value="CDE47415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47415">
        <property type="protein sequence ID" value="CDE47415"/>
        <property type="gene ID" value="BN770_00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="251" mass="28189" checksum="2DF6D0FC9B0B5ABA" modified="2013-07-24" version="1">MNEKNQQVSDEQIDALIRSGLWQDEQPLTADEEKLADAAFARAMAKIDRKAKQQKRRTVLHMLDRVVRVAACLIVAVGIAFPIALANSEAFREQILQLVLSINPETGMAHVGMEPAKEEQTANVPRMDVPDGWEGLFFPTFLPDSLPLVRCETTRGDQVQSEAYYADETRSLRFEEQDNLDGWNVRAADARVLTIYLHSVPGYLIDRQTEDTHEVSIIWAEGKRMLRVTSIGLPADEAVLVAQSVKKIFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>R7I6Z8</accession>
    <name>R7I6Z8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000046">
        <property type="protein sequence ID" value="CDE47425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47425">
        <property type="protein sequence ID" value="CDE47425"/>
        <property type="gene ID" value="BN770_00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="162" mass="18781" checksum="1928240D46BF3AAA" modified="2013-07-24" version="1">MDKELAGFGWYIKRIDNAIAREACRNVQSHNLTMQQSHLLFVLSDAENHTRTLKELESIFGCAQSTLAGLVTRLEKKGLVEGFTDPRDRRIKHVRLTESGAEMRQTCHKDILQSEKRMSAGMTEEEKQLFLQCLQKVYENLKDDMDETEHCHNNYHNNEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7J9</accession>
    <name>R7I7J9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CMP-binding-factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000040">
        <property type="protein sequence ID" value="CDE47233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47233">
        <property type="protein sequence ID" value="CDE47233"/>
        <property type="gene ID" value="BN770_01174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="158"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="318" mass="35738" checksum="9CC8A05324C28D27" modified="2013-07-24" version="1">MTVNQLETNARFVGFLLVRSADARTDKKGGSYLDLTLADKTGDINCKYWDWNQLMDVPKQGSVIKVQGLVQEYNSRKQLRIERMRAALPQDEVDMAQLVACAPEKPEVMRKDIEDTIDTFQSEGLKKIVREMLRLTGDKLEWFPAAQRLHHAERSGLLHHTTSMLNLARHVVAAYPFLDAELLYAGVILHDLCKTTEMISDETGSVSDYSADGLLIGHLVRGVARIEEAAKNVGVSGEIVLLLEHMVLSHHSIPEYGSPKAPMFPEAEVLARIDDLDAKMNEMQGILARVPEGAFSEKVWSLDRRIYHPKYQEIDGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I7Z4</accession>
    <name>R7I7Z4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylosidase/arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000059">
        <property type="protein sequence ID" value="CDE47725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47725">
        <property type="protein sequence ID" value="CDE47725"/>
        <property type="gene ID" value="BN770_01327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="221" mass="24121" checksum="E272EAF1386FC084" modified="2013-07-24" version="1">MAGKTYGTPVETWRKPSQTHQPPLSLQCSDDFADSLGLQWQFMGNWRADFYAVDGGLTLAALPAPNGILWNCPHVLTQKIAAPAFTAEVTLDARALQIGEQAGFGLIGGQYAYIALRRTAAGMRLVFVQSDGEAHQERVCEEIDAPAEQLALRMVLQPTGEDTARAAFAYQHQGNWRRFGEPFSPARHTWVGARMALFAMSLDGENHGGAGKFGPFRVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7I800</accession>
    <name>R7I800_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000076">
        <property type="protein sequence ID" value="CDE47994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47994">
        <property type="protein sequence ID" value="CDE47994"/>
        <property type="gene ID" value="BN770_01477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE47994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="306" mass="34052" checksum="77326F0E8D5B3DBD" modified="2013-07-24" version="1">MSEPLLKVENLVQYFPVSRTYTVKAVNGVSFNIYPGETYGLVGESGSGKTTIGRSIIRLYNPTDGRITFNGKVISGALDRNTRSMLRSDMQMIFQDPMASLNPRKKVGDIISEGMDIHHRFANRQEREEKISEMLKKVGLSPEHAARYPHQLSGGMRQRVGIARALIMNPKLIIADECISALDVSIQAQVVNLMKDIQAETQCAYLFIAHDLSMVKYISDRIGVLHLGYMVESGTKEEIFSHPVHPYTKSLLSAIPHPNPVVEKHRVALTYNYATSGIDYAKGTEHSAGGTHTVLATDEEFDAWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8E1</accession>
    <name>R7I8E1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-layer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000024">
        <property type="protein sequence ID" value="CDE46767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE46767">
        <property type="protein sequence ID" value="CDE46767"/>
        <property type="gene ID" value="BN770_00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025965">
        <property type="entry name" value="FlgD_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13860">
        <property type="entry name" value="FlgD_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435595" evidence="1">
        <location>
            <begin position="23"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="FlgD_ig" evidence="2">
        <location>
            <begin position="427"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE46767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="505" mass="55131" checksum="793D7848B445CC85" modified="2013-07-24" version="1">MWKRLMSVLLVVLLCCPIFAVRAEKITANGRVNRALLVGCDRFLTQTDTTPSSRNNVLRMADALSGGTLNMQTLVTREDGLSSASALVALIRETFSGADADDVSYFYISTHGLWNTAVNGLMTLLLSDGESEEGITAYELRRVFDTIPGKKVLLLDACHSGAMIGKGVEKSFENLFAGDNYYVVCSSGGEEESWYWSGEVSGERLAGAGYFSGALADALSRTGSFGADENRDGAITLTELRRRLLQSHGASTVRTYPEDSDFALFSYDLSAVSSRRRETSIEGITFSGDTLSADAPVIDFSFNVVRTAQVAYQLVYRRQGIWDFDQSTLIYDNNGDFGSYAIAGRTLSPGLKERSITLNTADAQSSGYVLLQILVIEKGLPSVVWSKVLCVPPTTDDPQLRVHVQDTFCPESGEELTFVVYHGVPCELTVTIEDEAGQTVRRLSSRQASRPEQLSAPGSTFCWNGTDSQGKLVNAGLYRVRVKAYVGTERYEVESGWISLTEMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8E5</accession>
    <name>R7I8E5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Met) cytidine acetate ligase</fullName>
            <ecNumber evidence="1">6.3.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmcAL</name>
        <name evidence="2" type="ORF">BN770_01412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:58144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TmcAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CBJB010000069">
        <property type="protein sequence ID" value="CDE47880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47880">
        <property type="protein sequence ID" value="CDE47880"/>
        <property type="gene ID" value="BN770_01412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01539">
        <property type="entry name" value="TmcAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008513">
        <property type="entry name" value="tRNA(Met)_cyd_acetate_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37825">
        <property type="entry name" value="PTHR37825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05636">
        <property type="entry name" value="HIGH_NTase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="390" mass="41505" checksum="7C994FBA8A03DA0C" modified="2013-07-24" version="1">MRIVGVIAEYNPFHSGHAHQLRQAREAAHADAVVAVMSGCFVQRGDAAIVSPAIRAKMALQNGADAVILLPALWSVRDAEHFALGGVHLLTGLGCDALSFGAETADLPLLQEAADALESPDLPAAIQPHLSAGLPYPAALSAAMAEVAPAAARVLQSPNNTLGVCYLRALRRLGASIDVYPIARASDYHASAIVDGFSSATAIRSAILRGDWSSAYSAMPGSAADLLENQALENHLHRPESLDSVLLARLRLMDEVDYAALPDISEGIERRLRRFADTARARDSLLQSAKTRRYPYARLSRLATHALLGVTQAVVDSNPLPPAAFLLGFRRGCEPLLSHLAQGVIPLVSSAAQCGKDAAWAQVERRAWGLWALGAGVDGDMWQRYGVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8H8</accession>
    <name>R7I8H8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000071">
        <property type="protein sequence ID" value="CDE47915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47915">
        <property type="protein sequence ID" value="CDE47915"/>
        <property type="gene ID" value="BN770_01428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004435600" evidence="1">
        <location>
            <begin position="30"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="87"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE47915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="293" mass="32033" checksum="7E1505ED4E798C2A" modified="2013-07-24" version="1">MRKFLSLFLALAMSIACCTLAAAEDTAEAMQYTEENITIDAGDHQIPATLTVPVGAEGEKFPAVVMLHGNGSTRHEAGNAYDYAALAMAKAGIATIRFDYIGNGDSTSDYIDFTYDKGVEDAMKCYEYLKTLGTIDMDHVGVMGWSQGGRLALLTAARNEVFTSVLTWAGAYDQKGNEEEQYAIAKENGYYEVTYDWREPLKQSPAYYECAMSIDYPAEVAKIKVPLLAINGKADTTVVPETAQKIVDAAVNSPDAEVLLLDGADHTFCVFSNDDTVLKTLVQDTIDWFKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7I8T4</accession>
    <name>R7I8T4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_01501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48025">
        <property type="protein sequence ID" value="CDE48025"/>
        <property type="gene ID" value="BN770_01501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="137"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE48025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="353" mass="39198" checksum="873DB9D1C93E3248" modified="2013-07-24" version="1">MMMNKKKPFSLHLDVDSFMPATAEEKEVISRMRPSSTFFRDGVKRLLKNKVATISLILIVLITLSSIIIPMFWPYSYDQMLGQTKGRPMDNSYNNLAPFQYGKTELKKIDKGESVFPHIFGTDAHGRDYFIRVVYGTRISLAVGFFASIIVLVIGMMIGAVAGYFGGRVDLFIMRIVDIIYSLPDMLVIILLAVVLGQVLHVEGTILEKIGSNIISMFIVFGLLYWVGMARLIRGQILSLREQEYVLSAQATGAKARWIIRKHLLPNCISVVIISTALQIPNAIFTESFLSFLGLGVNAPMPSLGSLASDALNGIYSYTYRLIIPAVVICLIVLSLNLFGDGLRDAFDPKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7I909</accession>
    <name>R7I909_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000100">
        <property type="protein sequence ID" value="CDE48359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48359">
        <property type="protein sequence ID" value="CDE48359"/>
        <property type="gene ID" value="BN770_01672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448090" evidence="1">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="164" mass="17539" checksum="0E1B2B9FFBB77523" modified="2013-07-24" version="1">MKKLLALVCALVLSLSMTAVLAEETDAFTSASVASYYADSALTGDDLMNAINSFSGTYLVCTTNPDGTANAGVFIFACVKNEDKYYIQMGLAENQTKQNLLRTGEALAVYAANPSTEEGAKPYITAGARMVLQQVTDEELLKVLNVKGSETALFFEITEIKPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>R7I963</accession>
    <name>R7I963_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BN770_01694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CBJB010000105">
        <property type="protein sequence ID" value="CDE48419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48419">
        <property type="protein sequence ID" value="CDE48419"/>
        <property type="gene ID" value="BN770_01694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="9">
        <location>
            <begin position="78"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="7">
        <location>
            <begin position="196"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="8">
        <location>
            <begin position="317"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE48419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="863" mass="96656" checksum="AE5209123FEF9697" modified="2013-07-24" version="1">MREQISLNGTWQLKGTASYVPLRDKSMETGKPLEGVTGWMDAQVPGGVARALYQAGYIDHPYVDMNSLKCEWIENRWWIYRREFDRRDIPAHRKTLLHFEGVDYACMVYLNGHLLGEHEGMYEDFAFDVTDLLQTAEHFVLDVLILHAPDEMGQIGRTSQTSTQKSRFGYKWDFSTRLVNLGIWQDVSLILEDEAALDDLYVHSDAANGTGLLHISGTTRADGNLPLAVTVRCAKDGAEKAAATLPVQDGAFAGTLTIPSPELWYPNGLGAQPLYDVTLTLRNGETVLDERTMRQGIRHFEMIQNEDAPAGALPYTIIMNGERVYMKGVNITPMDHIYGDIPAEQVAYQLHQAKRLNVNIVRVWGGGVIETETFYRLCDELGLLVWQEFIQSSSGVDNIPSELPHFLTLLRQSAVHALKVKRNHTSLVIWSGGNELMDENRKPVTLENKNISMLADLVRMLDPARMFVPTSPSGPEAHISRTPGMSHDVHGWWQYQGNGRQYSYFGDTDSLLHSEFGCDGMSSMQTVARTLSKCPTKPERMKGNDLWRFHGDWWCTYDREEAMFGHVEDIRRYICLSQWMQAEGLRFILESNQRRKWHNSGSIIWQLSEPWPNLSCTSIVDYYGHEKQAYYWTKDAFAPLHPTLDYRRLDYAAGTAGGGALNGAAGSGGGGGALTVLTDSGIAGDAEVAWSVRGLDGATYAEETRTAHLAAAVVNRVGDVAFVMPQTADELVLVRLTVRLGERTAVNEYYFSCENNRPYRAAASLHGGHLTARALETSPDSAVIEVRNTGDTAVLFADITDASDEWNLVRDDNFRTLLPGERWQTQVQWSRRFRIGFDDFTAHTTERPILTVDGIGLDAPVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9B5</accession>
    <name>R7I9B5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DnaB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000067">
        <property type="protein sequence ID" value="CDE47863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE47863">
        <property type="protein sequence ID" value="CDE47863"/>
        <property type="gene ID" value="BN770_01398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="1">
        <location>
            <begin position="246"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE47863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="334" mass="36945" checksum="6240BAA56AF418BB" modified="2013-07-24" version="1">MCNVNYLIEIRRFNTFAARTRLPASAQLLWYKLIEIMNQHARGGDWCDGFLRIDNPYLLAYFPMSATALADARRTLCEAGLLEYIPGEKKRTPPAYRLRYFSVCDGKGAVERDYPREIGADSTADCPADCPEIRDDPRDHPNYPSVYPSVYPTDCTTDCTTDCHGNTPDFHDTNINYTETETETVNPTGKTNDDEKETSAFSAGYAGAGACTGAYACTEAGAREGAFPRSVRESAKLAGKVLLHQQFTENQLNRVMAAFGAYPFEDGLMIQAVAKTAEANPTNAVNYLIQLLTDWGDAGIRTVAEMEDYLYARDMAQGNALMHTREEGRALLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9K4</accession>
    <name>R7I9K4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000083">
        <property type="protein sequence ID" value="CDE48171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48171">
        <property type="protein sequence ID" value="CDE48171"/>
        <property type="gene ID" value="BN770_01569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="92" mass="10443" checksum="1622F3B8734EBABF" modified="2013-07-24" version="1">MCCQVNVTKGTLSQAEIDAYVDHARQKYNREPLSMDIAVDGDEVELSYDFGNVPFQRIRRITGYLVGTLDRFNNAKRAEEHDRVKHGMPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9V6</accession>
    <name>R7I9V6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48385">
        <property type="protein sequence ID" value="CDE48385"/>
        <property type="gene ID" value="BN770_01676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="20"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="409" mass="44734" checksum="B640385D7E46D6A6" modified="2013-07-24" version="1">MKTTDYRRDFPLLMQETAAYLDNAATAQRPQCVLDAEKTFYETQNANPLRGLYPLSIAATEAVEEARLAVRDFLHAKSSQEIIFTRNTTEALNLVAYSYGLSHVHAGDEVVVSILEHHSNLLPWQMVCRQTGATLKFIDCEMDGRLDLNKVAEVITEKTKIVAVTHVSNVIGRVNPIREIADMAHRVGAVIVVDGAQSTPHIPVDVQALDADFLAFSGHKVFGPMGIGALYGKRRLLEKMPPFLSGGEMIESVTRTGATYAELPYKFEAGTGNAAGAVGLHAAIRYMQSVGFDTMHERETALVARMMAGMADMPFIHVLGSGSPEEHSGIVTFTVDGVHPHDVSEILAADGVCIRAGHHCAQPLLKHLGYSSTVRASCAFYNTPDEVNRLLDSLKTIRERMGYGKQELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9W3</accession>
    <name>R7I9W3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_01595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000092">
        <property type="protein sequence ID" value="CDE48246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48246">
        <property type="protein sequence ID" value="CDE48246"/>
        <property type="gene ID" value="BN770_01595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE48246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="197" mass="20874" checksum="617290DF90C520E9" modified="2013-07-24" version="1">MGKGIVHIHAAPNGGAGNQRGGNNEHILPLAKKFGKRNVTLAGFILYAIGGAICWAFPTNMTIMLIGQFIKNIGGLPCAYAFMALFADVLDHLEWKTGFRPDGVAMSVYNIIAVAMVGICTGVFNGLLGSAGYIAPEIVSGVTMAAAQSDTVKGVITFGFVGLEVFTGVLLALLLVFLNVENGIEKKQTEIKEREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7I9X5</accession>
    <name>R7I9X5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetyl xylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000104">
        <property type="protein sequence ID" value="CDE48405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48405">
        <property type="protein sequence ID" value="CDE48405"/>
        <property type="gene ID" value="BN770_01686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="355" mass="39097" checksum="CC8C18C506A908BD" modified="2013-07-24" version="1">MYTPDLLTMTDGTPVTSSAQWEARRGELLNILAREQYGTFLPPSTASARVMAPPMPACAGHALQETLEVRFDTPAGEFAFPLRFLYPADGQAHPLFLLLNFRPLIPDIYCPAEEILDNGFALAVVCYTDITADDSDWGSGLCGHYPRKHPETDPGKLVFWAYAASRALDVLTLRPEVDARNIAVIGHSRLGKAALLCGAQDARVRFTCANDAGCGGDALEQTKHPGAEDYAAMARSFPYWFCGNRSRYIDHPEERPYDQHFLLGAIAPRFAAVSSASLDRWADPYSQQLCCAAASPAWKLHGLRGFVGTESPAAVGAAYPEGHVAYHLRGGLHYLSRQDWLFYMDFVRRHKGETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>R7IA76</accession>
    <name>R7IA76_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NifU_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000102">
        <property type="protein sequence ID" value="CDE48386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48386">
        <property type="protein sequence ID" value="CDE48386"/>
        <property type="gene ID" value="BN770_01677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="143" mass="15781" checksum="02F880CCC4D0E43C" modified="2013-07-24" version="1">MENRSFYNEILTEHNIHPEFKHDLPDANIELEGVNPSCGDDITLKLKVDGDVITDGAFVGDGCAISQASADIMLGMIVGRKKEEALRLGEIFRKMIQGEATAEEIDELEEAGALKDISHMPARVKCAVLGWRTLKEAIGREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IB35</accession>
    <name>R7IB35_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000119">
        <property type="protein sequence ID" value="CDE48765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48765">
        <property type="protein sequence ID" value="CDE48765"/>
        <property type="gene ID" value="BN770_01816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE48765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="175" mass="19839" checksum="2D4E59889A31A98B" modified="2013-07-24" version="1">MATGERIRFFRTLRGMTQKYLGLLLGFPESSADVRLAQYESEDRTPKAELTGQMAEALDVSPKAIAVPNIDTMDGLMHTLFALEDRKLLRITNTDGLICLRAEIFDGGIHAADLEQRFRAWQEQSARLAAGEITKEAYDRWRYHYPDFDDMRIHAAVPPEASAVRKRGRKPKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBA1</accession>
    <name>R7IBA1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_01932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49189">
        <property type="protein sequence ID" value="CDE49189"/>
        <property type="gene ID" value="BN770_01932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="447" mass="47548" checksum="A3CB7289BF5C7D01" modified="2013-07-24" version="1">MNKHSTVRKQFFRYVSQNILGMIGVSAYILADTFFIAQAQGADGIAALNLVLPVYSLIFALGAMLATGAATRFALERHEGKHADSYLAEALAWAGILSVPFILLGIFSAEGIVRLLGGEPDIVTVGAPYTRIFLLFTPFFMCNYILRSFVLNDGDPSLAMTATMASSLFNIVMDWVLMFPLKMGMAGAALATAASPIVGMGINALHFRKKTNTLCFRWHKPTFKLLAHVSAVGVSGFIGEIAGGMTTMVLNFLILGLSGSIGVAAYGVVANVAIVATAIFSGISQGSQPLLSDAYSRGETGQVRQVLMMSILTALTLSVLMIVCFEVFAEPLVAVFNSEHDPVMADLACQGMRLYFLGYLFAGFNIAGTGYLSAVGAAKWAMITSILRGVAAIVLCALVMAALFGMTGVWLAFCAAEAITAGVMAVAMKKTDKSKCGQNEFDEKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IBZ5</accession>
    <name>R7IBZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BN770_01503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000077">
        <property type="protein sequence ID" value="CDE48027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48027">
        <property type="protein sequence ID" value="CDE48027"/>
        <property type="gene ID" value="BN770_01503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDE48027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="329" mass="36545" checksum="82C2204124F0723F" modified="2013-07-24" version="1">MSEAQMHQPLLEVKGLKEYFDINMGFFRTKPLKAVDDVSFTINKGETLGLVGESGCGKTTVGRTILQLYKPTAGEIIYDGKPVKTKADLQKFRTKATMVFQDPYSSLNPRMTVSDIVGEPLDVHHLYSSKKEREERILQLLGYVGLNSEHASRYAHEFSGGQRQRIGIARALAVNPEFIVCDEPVSALDVSIQAQVINMFDDLQDRLGLTYLFIAHDLLVVRHISDRIAVMYLGKMVELASAEEIYNHPLHPYSKSLLSAVPLPDPKAARANKRIVLSGDIPSPLNAPSGCPFRTRCPHATEACAQSMPPFNEVEKGHFVACHRVKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICE7</accession>
    <name>R7ICE7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ORF">BN770_01954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CBJB010000139">
        <property type="protein sequence ID" value="CDE49240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49240">
        <property type="protein sequence ID" value="CDE49240"/>
        <property type="gene ID" value="BN770_01954"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="256" mass="28273" checksum="80260ADBE0E94749" modified="2013-07-24" version="1">MMGNQNPVGVFDSGVGGIGTLSALRRELPQEDFLYFGDTLHAPYGTKPREEVMACVTRVMTHLLANHVKAVVIACNTATAVAAKELRETYDLPILGMEPALKPAHALRHGGSILVLATPMTLRLEKFQQLYARYGEGAIPLPCPGLMELVEQEANEQARRYLLELLHPYDLRTVDAVVLGCTHYVFLRPLLREILPENVQVLDGNEGTARQLRRVLTENDLLCARETPGKITLETSGAPETVLPVMQRLLVRADTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICN4</accession>
    <name>R7ICN4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000143">
        <property type="protein sequence ID" value="CDE49370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49370">
        <property type="protein sequence ID" value="CDE49370"/>
        <property type="gene ID" value="BN770_01985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="390" mass="43763" checksum="DBAB7A02A81C6853" modified="2013-07-24" version="1">MANAILIPGKEKRVYSGHPWVFRSDIARVEGDFTPGDIVSVYSSKGKFLAKAFYNPQSQISLRIMSLHDEPIDRAFIFRRVKEAIDYRRTFADLRSCRLIFAESDRLPALIVDSFGDVLVLQCLALGMERFKQDVVDALVEEVHPQGIYERSDVPVRRLEGLEQLTGVMYGTVPDRVEMVENGVHFWVDVKEGQKTGFFLDQKENRAAIAPFVKGKTVLDCFTHTGSFALHAGHYGAKEVTGVDISAFACEFATENARLNGLENVVHFVEANAFDLLAEQSRAGVKYDVVILDPPAFTKTRSAIEAATRGYKEINLRAMKMVKPGGYLITCSCSQHILPDAFMQIVRDAAHDAHVQLRQVEYRTQGRDHPILPAAPETQYLKCGIFQIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICY9</accession>
    <name>R7ICY9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="2">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GlcN6P deaminase</fullName>
            <shortName evidence="2">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nagB</name>
        <name evidence="4" type="ORF">BN770_02033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="2"/>
    <dbReference type="EMBL" id="CBJB010000144">
        <property type="protein sequence ID" value="CDE49505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49505">
        <property type="protein sequence ID" value="CDE49505"/>
        <property type="gene ID" value="BN770_02033"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="3">
        <location>
            <begin position="26"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDE49505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="247" mass="27235" checksum="A477DEEFD0E60682" modified="2013-07-24" version="1">MKIIRARDYQHLSRQAANILSAQVILKPDSVLGLATGSSPIGTYQQLIAWEHKGDVDFRQVSTVNLDEYVGLPAGHPQSYAHFMRENFFDHIQIDLRDTHIPNGMAEDGDAECRHYDATIRQLGGIDLQLLGLGPNGHIGFNEPEDVFQKDTHRVALTDATIQANKRFFASEADVPHFAYTMGICGIMQARRIVMVVSGESKANILKQAFFGPVTPRVPASILQLHPDFTLVADEAALSALDGTETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7ICZ4</accession>
    <name>R7ICZ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_01696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000105">
        <property type="protein sequence ID" value="CDE48422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE48422">
        <property type="protein sequence ID" value="CDE48422"/>
        <property type="gene ID" value="BN770_01696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE48422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="519" mass="58064" checksum="2D1F9650D75F320E" modified="2013-07-24" version="1">MLHLPVEPVPPRLNELPLVQPGAFLADALFLVNHLHAVDKIFLHPVCIAVELNVLHAMRKVNRARASIQPKAPPIPELEGEDIGHRADFQHHAVPAGAVYCSGGNQEVVVLFRRNNVDEAFRVELPGLLTVFQRFLEFFRLNARLAAQIDMRIGVFRRVEDVVAFVLRVVHPERVLNVLGQRMHLQAQISAADGVQKVKANREFRAEARVNLVTQERFSFLMYQIDGGRFHDDAVHIQQEAVFLRHTIEAPCVIGLFRVKPADGLHPLPAPDAGVEIRRNAEGLRDRLFERIAVAVAGHHAGRLGVVGVQQVVNMRMQRPLVAVEDAPFDEVAALIFAQRVFAVVVIEPVCQFAGAEAELDFPARHVRIHQYIGMLAQQRRADAEHQPDTVHQCDFLPKHRYPFHVEELLDAVVRHDAEHTVIGQVVFQHGIDLLFGERRLCRAEDARRVQLLCQRAQHIHLPHAVIAVHANDGVRLACNGFAQLCTDSFPALPCADALCPHMKDRALIVIALSHACPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7ID30</accession>
    <name>R7ID30_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000146">
        <property type="protein sequence ID" value="CDE49550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49550">
        <property type="protein sequence ID" value="CDE49550"/>
        <property type="gene ID" value="BN770_00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="184" mass="20873" checksum="E8D40D790CB9FCEF" modified="2013-07-24" version="1">MKCEEREVICRDGRAALLRSAHPDDAAEMVRFLLDVCGETEFLLAYPEERQSLTDEGERTFLTRLTADDNELMLTAWVDGQLAGVANINFSTRLKMRHRANVAISIRRAYWRLGLGTAMLTELVDVAKARPEVRQVELEFIEGNSRAQALYEKVGFRVVGVHPDAFVLKDGAMKNAYLMQLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE14</accession>
    <name>R7IE14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent protease ATPase subunit HslU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49568">
        <property type="protein sequence ID" value="CDE49568"/>
        <property type="gene ID" value="BN770_02043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="49"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="7">
        <location>
            <begin position="346"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="456" mass="51082" checksum="9FA8EBFC0D0CCC72" modified="2013-07-24" version="1">MAELTPRQIVRELDRYIVGQDEAKRAVAIALRNRYRRSKVDDAMREEISPKNILMIGPTGVGKTEIARRLAKLVSAPFIKVEATKFTEVGYVGRDVESIVRDLVENAIRMVREEHTARVAPRARVIAEDRLVTLLVNPPKKPSNSFSLDYLLGRAKSPETPAKEENAELADERERLRQQLMKGEIEDRELEIEVEEAAPSLEVGGSAISLGDMMGNMMPKKTKLRRVKVKEARKILEQEEADKLIDQDAVQEEAIRRAEQDGIVFIDEIDKSAGRRGGSGPDVSREGVQRDILPIVEGSTVNTKYGPVKTDYMLFIAAGAFHVAKVSDLIPELQGRFPVHVQLKSLTREDFQRILTQPDNALTLQYKALLAVDKVMLTFEDSAIEAIADAAFTANETAEDIGARRLHAVFEQVLEDISFNAGDENMPPFELTINGEYVQQHLSGENKPTDLRKYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IE80</accession>
    <name>R7IE80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BN770_02059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000147">
        <property type="protein sequence ID" value="CDE49628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49628">
        <property type="protein sequence ID" value="CDE49628"/>
        <property type="gene ID" value="BN770_02059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="82"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDE49628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="224" mass="24807" checksum="3C21392CC78D71BA" modified="2013-07-24" version="1">MEGFSEHEVLELILFYGRARGNVNDTAHALMDVFGSLPRVLEASPEQLMLIDGIGEESATLLSLILPLFRRYSDEVNQVRSKLESRQVTLDYCRTMMAGYRREQFYVICLTADGSIICNRKVTEGTLSAVTAYPRLVLEAALNSNAHSVVLCHNHPGGVALPSEDDVCTTRYLQQLMEGVGIIVLDHVIVAGNQTYSMAQHGELLHPSEIMRAMVAAAEKPLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEL1</accession>
    <name>R7IEL1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="10">RNAP omega subunit</shortName>
            <ecNumber evidence="2 10">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpoZ</name>
        <name evidence="11" type="ORF">BN770_02117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 10"/>
    <dbReference type="EMBL" id="CBJB010000151">
        <property type="protein sequence ID" value="CDE49748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49748">
        <property type="protein sequence ID" value="CDE49748"/>
        <property type="gene ID" value="BN770_02117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE49748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8610" checksum="0B566FBAC9EAC977" modified="2013-07-24" version="1">MSIVEPCVLELLKHADSRYTLVVEASKRGRQIIGGSKPLLDNEGMKPLKTAVEEINRGLITYDEPNDENEDQDVDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>R7IET2</accession>
    <name>R7IET2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000152">
        <property type="protein sequence ID" value="CDE49828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49828">
        <property type="protein sequence ID" value="CDE49828"/>
        <property type="gene ID" value="BN770_02152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024232">
        <property type="entry name" value="SpoIIIAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038503">
        <property type="entry name" value="SpoIIIAH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12685">
        <property type="entry name" value="SpoIIIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005709524" evidence="1">
        <location>
            <begin position="40"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE49828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="167" mass="17920" checksum="8D9674AF07227E60" modified="2013-07-24" version="1">MKLQSLPTFLVRRKNWLLMAALALSLTAALLLRPSSPQAQRVTLPMTSAESSASPLEAFRISRDSAYQRDMAALETLISSENTDRAARQSAAEELQAYVALHQAQLALEGALLTSELAPCCAVVTDGSVTIVTEKQEITEQDTALVLTLVQVHTGVPASGVRIMTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>R7IEZ4</accession>
    <name>R7IEZ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BN770_00184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MGS:74</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000168">
        <property type="protein sequence ID" value="CDE50369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50369">
        <property type="protein sequence ID" value="CDE50369"/>
        <property type="gene ID" value="BN770_00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDE50369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="461" mass="52628" checksum="99455E187682DA09" modified="2013-07-24" version="1">MKGKDFLWCGCLSGKATLPQSIRFCRGVFCLQEYNSPEEYIKDVQRYIRWSRAKVVATRELSDHINDQYDALRENGLNQKEAMRKAIEEMGDADVVGTELDIVHRPKVNWLLLLIAGVLLLSGILISAMLTSISLTVPKIIGIVLGVCVAAFLYFIDYTVLIRFPRALYGLLSLAAIFGLLYELWNGFAPLGYGFLFYLLLCYPIVLVGILFYEKNSESETKIIHYWLYAIFPLTLALINQAFPVFVLLLACELFIFCCGLKLKWLKWNRVNIFGVACMLIFLIIGVYLLSRFYHLFRLQENTGYLQQLDFFSVFREAELIGKSGMPVDVKVMSYFYDHPITLLLYEYGKFSLVFLLFVFGILFAILYRTSKKQDTEVGKLLTNTVLLIYILRIVFTALSDIGVLPNFFMCVPFVVTGGMFIIYDMALVGIILSVNRNESIAKDWIKLKSKRNAAKNGGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF45</accession>
    <name>R7IF45_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="15">PRA-CH</shortName>
                <ecNumber evidence="15">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="15">PRA-PH</shortName>
                <ecNumber evidence="15">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">hisI</name>
        <name evidence="15" type="synonym">hisIE</name>
        <name evidence="17" type="ORF">BN770_02206</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">MGS:74</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 15">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="15"/>
    <dbReference type="EC" id="3.6.1.31" evidence="15"/>
    <dbReference type="EMBL" id="CBJB010000158">
        <property type="protein sequence ID" value="CDE49953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49953">
        <property type="protein sequence ID" value="CDE49953"/>
        <property type="gene ID" value="BN770_02206"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="16">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="15">
        <location>
            <begin position="117"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDE49953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="204" mass="22827" checksum="D32BB26DDFCB7E6A" modified="2013-07-24" version="1">MDFSQLKFDANGLIPAIAQDARTNQVLMLAYMNQQSIEQTLETGYATYFSRSRQALWKKGETSGHTQKLVAMRYDCDHDAMLLTVEQVGPACHTGAKSCFFNDVYVDEDAPATANVLQEDYATIADRAANPVEGSYTNYLLDNGVEKICKKVGEEASETIIAAMKANKEEVTYEAADLLYHLMVLLYQQGVTLDDVWAEMARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF66</accession>
    <name>R7IF66_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="14">ATP-PRT</shortName>
            <shortName evidence="14">ATP-PRTase</shortName>
            <ecNumber evidence="5 14">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hisG</name>
        <name evidence="16" type="ORF">BN770_02210</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">Lacks the C-terminal regulatory region which is replaced by HisZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5 14"/>
    <dbReference type="EMBL" id="CBJB010000159">
        <property type="protein sequence ID" value="CDE49978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49978">
        <property type="protein sequence ID" value="CDE49978"/>
        <property type="gene ID" value="BN770_02210"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 14" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="15">
        <location>
            <begin position="55"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDE49978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="219" mass="23921" checksum="905CB3E693DCBADE" modified="2013-07-24" version="1">MEQPVITFALAKGRLAEQAFDLLEQLGIDCSEPRNPGRQLVLWDKEQNVRFILVKPSDVPTYVDHGVADLGIVGKDTLLEAGRELYEVLDLGFGKCRLCIAGYPGEQGGSVNRATFRVATKYPNIARSYYDSKGQTIEIIELHGSVELGPVIGLSDVILDIVESGSTLRANGLTVLEDICDVSARLVVNRVAMKTKRERIRQIIDGLGALLAVKQEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>R7IF76</accession>
    <name>R7IF76_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="16" type="ORF">BN770_02405</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CBJB010000171">
        <property type="protein sequence ID" value="CDE50464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50464">
        <property type="protein sequence ID" value="CDE50464"/>
        <property type="gene ID" value="BN770_02405"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDE50464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="553" mass="58377" checksum="6493226830103B2F" modified="2013-07-24" version="1">MLSENIKQGVERAPNRSLLYALGLTDEEIRKPLIGVVSSYNEIVPGHMNLDKIAEAVKAGVRAAGGTPILFPAIAVCDGIAMGHVGMKYSLVTRDLIADSTEAMAIAHQFDGLVMIPNCDKNVPGLLMAAARLNIPTIFVSGGPMLAGHLTDGRRTCLSHMFEAVGAYKAGTLDDDGVRNYEENACPSCGSCSGMYTANSMNCLTEALGMGLPGNGTIPAPYSARLRLAKHAGMQIMTLVEKNIRPRDIMTPAAFNNAETVDMALGCSTNTMLHLPAIAHEAGVTINLDHANEISAHTPNLCHLAPAGDTFMEDLDRAGGVLAVMKELTKKDLLDTSVMTCTGKTMAENLEGVVNRDERIIRPVDNPYSTSGGIAVLKGNLAKDGCVVKQSAVAPEMMVHEGPARVFDSEEDAIAAIYARKIVPGDVVVIRYEGPKGGPGMREMLNPTSAICGMGLGESVALLTDGRFSGATRGASIGHISPEAAAGGLIALVEEGDRIAIDIPKCTIELKVDEETLAKRKAAWVCPEPKVKTGYLARYAKLVSSADKGAILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFJ3</accession>
    <name>R7IFJ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxyl-terminal protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BN770_01979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000141">
        <property type="protein sequence ID" value="CDE49332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE49332">
        <property type="protein sequence ID" value="CDE49332"/>
        <property type="gene ID" value="BN770_01979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="79"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDE49332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="381" mass="42226" checksum="439744EF4A63FBF4" modified="2013-07-24" version="1">MGKQMANAANDDTSGDTVTISREEYEKYKQFDKLLELMDIVDEGYFEDYDKQSLLDGAADGLLSGLGDPYTFYYTPEEYAKLWEDDEGEYAGVGIQISTSYLTGICTISRVFDNGPAHEAGVRKGDILYKVEDLYVNSSTINDAVDIMRGTPGTDVHVTFLRGTEEMAYTLTRANINVNRIDSMMLTDEIGYIYLYDFAGDCAEKFETTVNKMVENGTKGLIIDLRDNPGGWVNDAQSIADIFLDKGTLCYLQYKNGERYYYRTKDGKVEMQLVILVNENSASSSEILTGALRDRANAIVVGKKTYGKGIVQSVVPLSDGSGMQITVAQYYTPNGYAVHKQGITPDVEVDGDNGMYELGDLTDAQLAKALEVMQEKLAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFL8</accession>
    <name>R7IFL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ORF">BN770_02375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000169">
        <property type="protein sequence ID" value="CDE50410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50410">
        <property type="protein sequence ID" value="CDE50410"/>
        <property type="gene ID" value="BN770_02375"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="199" mass="21087" checksum="DC683EBA9953242B" modified="2013-07-24" version="1">MDVLAYLAIAVIAYLLGSISTGMLVSKAMGGPDLHKVGSGNTGATNALRTMGKKGGAIVFAGDVVKALLACLVGRLWMGQNGALLAGLFVILGHNWPVFFGFKGGKGVSSTCGVMLMTFWWQALICYVITIALIAITKFVSLGSLALVVLFGILVTATNWGNWLVIAWVWVIAGLCIYRHHANIGRLIHGTERKIGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFP2</accession>
    <name>R7IFP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_02301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000162">
        <property type="protein sequence ID" value="CDE50153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50153">
        <property type="protein sequence ID" value="CDE50153"/>
        <property type="gene ID" value="BN770_02301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004447926" evidence="1">
        <location>
            <begin position="29"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="247" mass="27526" checksum="A324D63CDA80BAF9" modified="2013-07-24" version="1">MKHPVKKIISHLLMFALVLCVAIAPSLAESKPDCLQTISGENGTTYSNLFDVILSDDYDSVWEEHCKAIVGEENAAEAVEMLKSFISGDVYGDDAVALYGDGSEGFIFDCWYLNDVKSFTMNGDEITINKLDGTSETHKYRCIGTYQIGAEETMTWGGETFCPAFDCEVYQATDDAGDFTYFFFRDDTMETTYHIEFRYGSDLAALQQYMKGQYAYWLAAGIDANADAETIDNVIALFCTENLSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFT9</accession>
    <name>R7IFT9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_02318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000163">
        <property type="protein sequence ID" value="CDE50193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50193">
        <property type="protein sequence ID" value="CDE50193"/>
        <property type="gene ID" value="BN770_02318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="578" mass="64264" checksum="70027D25732914DA" modified="2013-07-24" version="1">MLRAEVAVNRRFRHLVGVRPRGFHRAVGVVLRINRLRFVPVCPKRRIRCCGVQLDCLCGGRFRCPARIRGIDMAGARHGNPRLRAFRRGLVRGIAGSVQPLLRHVEAVQTFLLARQLVVRHGDGGASVRIALRRHETVRRAIADAEREGGFVLVLDLLHLVAVALPDGLILLVEARHSVLRESAEHDLACVQAADAHDPRDRLEAVVRDPRAVLLLFAGQAEGQRILHVFRLRAFTPALLGFDGQLRDLVVPQRRRAACVLRVRLRIGGIPVREVLARVLRETAVCQLAVEAARHVQFPEAVGVGVGVLDNAVFHGDRVGFQPLELGAPFVCFCQCDRFAAFRAALRPRAVDVIPARLVERDLYAAEFLGNRVLCAIRRVPFLGQVDADFAVLVLRAVDVGQRRRDRAGGFAGVRVDGVGDAGCGVARHFALDDVVNVVELVAVRVRAGGFQLRPLGVPAVRCRQHSLATAVSVVRVLANFCPLRIGELRDLRRHFVNRCAFRGHRDAHVVIVATVLPFSFPVFPLQAENHFFLMRHLGGVNELFSRRILRFQDHFFSVYASHNTRSVVKCAIKQVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFV7</accession>
    <name>R7IFV7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="10" type="ORF">BN770_02424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CBJB010000172">
        <property type="protein sequence ID" value="CDE50505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50505">
        <property type="protein sequence ID" value="CDE50505"/>
        <property type="gene ID" value="BN770_02424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="148"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE50505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="222" mass="24347" checksum="B8E4405300B74DFD" modified="2013-07-24" version="1">MMQQFLSALGYQFKNPALLRRALTHPSMGPEDNQRLEFLGDAVLQCIMSDILYQSHPDCHEGQLTHLRALSVCEANLSQVAKKLHVGEALIMDKGEELTGGREKPSVLCDAMEAILAAVYLDGGLDAARAIILRCWPKPEDVQRPMQDSKGALQEFLQRDGSEAPTYEIIAQDGPPHNRTFEAAVSRFGVELAHGTGRTKKQAEQAAALAALQKLKSGDKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>R7IFZ9</accession>
    <name>R7IFZ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="11" type="ORF">BN770_02437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000173">
        <property type="protein sequence ID" value="CDE50550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50550">
        <property type="protein sequence ID" value="CDE50550"/>
        <property type="gene ID" value="BN770_02437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDE50550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="165" mass="17534" checksum="E755025F9B7B0F03" modified="2013-07-24" version="1">MQRYGQESEFKDRLVAVNRVSKTVKGGRNMRFSALVVVGDEKGRVGAGMGKAAEIPEAIRKATEDAKKHLVTVPMDGTTIPHNTTGYFSTSKVVLLPAPEGTGVIAGGAARAVLELAGVADIRTKSFGTNNPINMVKATLEALKQLRSAEQVAKMRGKTVEELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGI0</accession>
    <name>R7IGI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BN770_00243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MGS:74</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000183">
        <property type="protein sequence ID" value="CDE50899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50899">
        <property type="protein sequence ID" value="CDE50899"/>
        <property type="gene ID" value="BN770_00243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDE50899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="140" mass="16402" checksum="CB9FE7A44FD9AE95" modified="2013-07-24" version="1">MQYYETDRMGVTHHSNYIRFMEEARVAYLEQLGFPYAELERRGVISPVTAVNCKYLATTTFDDRITVDVRVEAFNGVVLTIGYDMTKQDGTRVFTGTSEHCFLNPEGHFIRLRRDQREFYEMLMRELNVHHPAEGETSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGU6</accession>
    <name>R7IGU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50815">
        <property type="protein sequence ID" value="CDE50815"/>
        <property type="gene ID" value="BN770_00214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004448274" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="82" mass="8721" checksum="65DB36FA90A87A0A" modified="2013-07-24" version="1">MKRIISLVMALALVLTAMVVPAVAENQDVRTVEFWHTLTGVNGAAVEAIADHFNATVGAEKGIVVKAVYQGNDNSEKLKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGU8</accession>
    <name>R7IGU8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative trehalose operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000179">
        <property type="protein sequence ID" value="CDE50820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50820">
        <property type="protein sequence ID" value="CDE50820"/>
        <property type="gene ID" value="BN770_00218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="251" mass="28723" checksum="F6907DA2CDAB9977" modified="2013-07-24" version="1">MQFSIDRNSPVPAYYQIQLDLSDRIQRGEWNDRKQLPSESTLAEQYAVSRITLRQALAELEKDGIIKKSRGCGAKICEKPAPFVHKMDFYSIVSTHEGHDGKQVTSQVLNIRRFDMPTEDVIEHLQLEPGTPVVYIKRLFLFDDKPLAVGRSWLSLARFPGLDETGLGEKGLTATLRSRYNTIIRRFNDAIEAVRPAPDERNLLDVSYDCPLLMVRGLSFDQHNVPVEYSTTYWLGDKVRFTVSMNTQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IGY5</accession>
    <name>R7IGY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000180">
        <property type="protein sequence ID" value="CDE50860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50860">
        <property type="protein sequence ID" value="CDE50860"/>
        <property type="gene ID" value="BN770_00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025536">
        <property type="entry name" value="DUF4422"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14393">
        <property type="entry name" value="DUF4422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4422" evidence="1">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE50860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="257" mass="30067" checksum="91BA420695D979EC" modified="2013-07-24" version="1">MQQPRIFFAVALHEKYALPTDALYTPIQAGAAIHPPLGLMRDDTGENISAKNGSYCELTVLYWMAHNVDADWYGLCHYRRYFSLRRTGCPQKRILTRAQLLPLLDTADIFLPKKRHYWLETNFTQYAHAHHEEDLRKARAALARLHPGQERVFDRVMARRSGHRFNLMLMRRDALQSYASWLFPLLDAAEIDTTGYSARDKRVHGFLAERLLDVWLAQQNYRVKELPVAHLERQHWGRKIAAFLLRKMGIKNDRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHG0</accession>
    <name>R7IHG0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000182">
        <property type="protein sequence ID" value="CDE50891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE50891">
        <property type="protein sequence ID" value="CDE50891"/>
        <property type="gene ID" value="BN770_00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022118">
        <property type="entry name" value="Peptidase_C70_AvrRpt2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12385">
        <property type="entry name" value="Peptidase_C70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE50891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="263" mass="29995" checksum="E8F8B5DC1A6B3A32" modified="2013-07-24" version="1">MKKHGIRGLLILALIWALIGAAWAEEMLPASIREAQSAEEASALLIQSDTGERLNVVSGQVRLIVQTRRDDMFCADYWRSGEEKGEFDLTAKENRYGAPYAYYIGTMCTRAVYSMALSYLGVDMTPVDMSVLAQRRTLNEPYDEITALVDGLARRGLTEATFDEMMAQYLNDERYSPLYIYMKRTNGVGHALLIVGYNAERKRFVAVDPSPRGFQGDTVRTYELSFAQNRQRVMRCPYAKDLEGAKVLQVYQWYWIGEETEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHM6</accession>
    <name>R7IHM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding LysM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000207">
        <property type="protein sequence ID" value="CDE51264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51264">
        <property type="protein sequence ID" value="CDE51264"/>
        <property type="gene ID" value="BN770_00351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="233"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="278" mass="29881" checksum="5DD63D09B97196EF" modified="2013-07-24" version="1">MEQQGRRAIGRVCPRGAESYTWQEGDTAERIARTYATTVQALQVINPGVDFATLTAGEEICLPNFIYTCISGQPYVVEDGDTFASIAARLDITTFELAERNPGVSQNNLTVGQVLCVPAKADDADDAQTPAIPLPDDGEYPALPDDSQTPVIPLPDDGEYPALPDTPTRVCPSGYTLSAVQSGQSYADLLVQHNVSYRAMRSTNPQLMPGYLIAGTAYCAPPSGTRQTCAGLRSYTIQPRETLDTLAVRFRTTRGRLLSLNPTLLPSDFSSGTVICIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>R7IHU9</accession>
    <name>R7IHU9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase alpha/beta domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BN770_00277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000187">
        <property type="protein sequence ID" value="CDE51046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51046">
        <property type="protein sequence ID" value="CDE51046"/>
        <property type="gene ID" value="BN770_00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDE51046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="244" mass="28100" checksum="90DE40F7C9E2AA26" modified="2013-07-24" version="1">MASDQERIAILFIHGILGTTSHFEPFLSLVPPNWSICNLSLKGHGGSVKDFSQASMTEWKQQVKNALEELSETNNKIIIVAHSMGTLFAIQEAIEKPVDELFLLNVPLKVRVTLRLFRTSWRVFTGNIKPDDKWSLAAQNAYSIERDNHILRYFGWIPRYLELFSEIRKTRKIIGKLLTPSHIYLSMLDEMVSPKCSKLFKDNPCICVKSLQTSGHFYYSPEDQCLMKEDFNKMIQNVQKEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>R7IIA6</accession>
    <name>R7IIA6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA</name>
        <name evidence="12" type="ORF">BN770_00387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="CBJB010000214">
        <property type="protein sequence ID" value="CDE51345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51345">
        <property type="protein sequence ID" value="CDE51345"/>
        <property type="gene ID" value="BN770_00387"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDE51345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="356" mass="38176" checksum="CE8F18B421611693" modified="2013-07-24" version="1">MKRRIGILTSGGDCPGLNAAIRGVTRAAYELFDAEIVGIHDGYRGLITGDYQEMKRSQFSGILTLGGTILGTARTPFRDMRKIGEDNVDKVAAMKKTYKDLKLDCLVTLGGNGTHKTANLLSKEGLNVIGLPKTIDNDLYGTDFTFGFHTAMDIATEVIDRIHTTAASHGRCMVVEIMGNKAGWLTLYSGVAGGADAILIPEIPYKIEKVAKVVESRAKSNKGFTIIAVAEGAMTPEEAKMGKKEREAKRAAEHFSSSAYVAQQLRDLVGVEARAVVPGHIQRGGSPNAYDRVLSTQFGVHAAELIRDGVYGVTVALKGNEITHNKLSDIAGVPKLVPPDNTMITTARNIGISFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJ82</accession>
    <name>R7IJ82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000236">
        <property type="protein sequence ID" value="CDE51685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51685">
        <property type="protein sequence ID" value="CDE51685"/>
        <property type="gene ID" value="BN770_00566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016621">
        <property type="entry name" value="UCP014543"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12646">
        <property type="entry name" value="DUF3783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="135" mass="14901" checksum="47F4B76117573960" modified="2013-07-24" version="1">MESKLILAFHVAPQKLGKIRFCAMKMGMRVMDVPLADCGQTLGALCGKAERQADAAAPENAVGSEMLYFAFSELPLVERFLTTMKQMRVPPVRLKGVMTETNLAWTPAQLYEELTREHQAMAGHGAPIHAAKQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJA0</accession>
    <name>R7IJA0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BN770_00648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MGS:74</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000248">
        <property type="protein sequence ID" value="CDE51839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51839">
        <property type="protein sequence ID" value="CDE51839"/>
        <property type="gene ID" value="BN770_00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDE51839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="161" mass="17904" checksum="3420B52436E8A1E0" modified="2013-07-24" version="1">MLTALRQELQEMLATVPTLRRPALRRSEDANALFATDLPLLADAADFCRLAEKHGWRTWMQGGWLLLDKLPNPPDMPTKIPDAPGELGCCLSLLARHPDDTADGTLLRALLKSADAGGQAMEKYCRMLHRDLAARLRTHNPLPGRLLPYLCRTAEERTGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>R7IJN7</accession>
    <name>R7IJN7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="10" type="ORF">BN770_00482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Faecalibacterium sp. CAG:74</name>
        <dbReference type="NCBI Taxonomy" id="1262897"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Oscillospiraceae</taxon>
            <taxon>Faecalibacterium</taxon>
            <taxon>environmental samples</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Dependencies among metagenomic species, viruses, plasmids and units of genetic variation.</title>
            <authorList>
                <person name="Nielsen H.B."/>
                <person name="Almeida M."/>
                <person name="Juncker A.S."/>
                <person name="Rasmussen S."/>
                <person name="Li J."/>
                <person name="Sunagawa S."/>
                <person name="Plichta D."/>
                <person name="Gautier L."/>
                <person name="Le Chatelier E."/>
                <person name="Peletier E."/>
                <person name="Bonde I."/>
                <person name="Nielsen T."/>
                <person name="Manichanh C."/>
                <person name="Arumugam M."/>
                <person name="Batto J."/>
                <person name="Santos M.B.Q.D."/>
                <person name="Blom N."/>
                <person name="Borruel N."/>
                <person name="Burgdorf K.S."/>
                <person name="Boumezbeur F."/>
                <person name="Casellas F."/>
                <person name="Dore J."/>
                <person name="Guarner F."/>
                <person name="Hansen T."/>
                <person name="Hildebrand F."/>
                <person name="Kaas R.S."/>
                <person name="Kennedy S."/>
                <person name="Kristiansen K."/>
                <person name="Kultima J.R."/>
                <person name="Leonard P."/>
                <person name="Levenez F."/>
                <person name="Lund O."/>
                <person name="Moumen B."/>
                <person name="Le Paslier D."/>
                <person name="Pons N."/>
                <person name="Pedersen O."/>
                <person name="Prifti E."/>
                <person name="Qin J."/>
                <person name="Raes J."/>
                <person name="Tap J."/>
                <person name="Tims S."/>
                <person name="Ussery D.W."/>
                <person name="Yamada T."/>
                <person name="MetaHit consortium"/>
                <person name="Renault P."/>
                <person name="Sicheritz-Ponten T."/>
                <person name="Bork P."/>
                <person name="Wang J."/>
                <person name="Brunak S."/>
                <person name="Ehrlich S.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">MGS:74</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CBJB010000226">
        <property type="protein sequence ID" value="CDE51533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CDE51533">
        <property type="protein sequence ID" value="CDE51533"/>
        <property type="gene ID" value="BN770_00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000018328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDE51533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000018328"/>
        </source>
    </evidence>
    <sequence length="435" mass="46073" checksum="1D45080196BF987C" modified="2013-07-24" version="1">MKNTKTKSIVALAIVLVLTVVFGIVGVTGMSFQGGLWKLLPWLPTTNADAWPQAISLGLDLRGGVYVEYSAEAPEGNDANFSDLLDATVSAIQSRLTDKGYAESTVQVLGTSGIRVEIPDVSDPSEILNLIGEPALLEFKDPDGNTFMTGSDVRLAQAAMTQDGQWAISFQLTSAGTKLFADMTSQNIGKTLGIYLDGEKLMAPTVQSAITGGSGQITGNFTMDRAQTIAAQIQSGALPLVLTQQKVDTVSATLGDNALSTSVFAAIIGIALVMLIMIVRYRLNGVVASWALCIYTIVLFWVLAVFPGIQLTLPGIAGIVLGIGMAVDANVVIFERFNEEVRAGRSLKVALKTGFHNALSAIIDANVTTIIAAIVLMIFGTGSVQGFAKTLLLGVIVSLFSALLVTRFLMKQFIQLKNWNVSAFTSGVQSAKEAK</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>